growth arrest specific 11


Gene Symbol: growth arrest specific 11
Description: growth arrest specific 8
Alias: CILD33, DRC4, GAS11, dynein regulatory complex subunit 4, growth arrest-specific protein 8, GAS-11, growth arrest-specific protein 11
Species: human
Products:     growth arrest specific 11

Top Publications

  1. Hill K, Hutchings N, Grandgenett P, Donelson J. T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes. J Biol Chem. 2000;275:39369-78 pubmed
    ..Although the function of the corresponding proteins is not known, the mammalian TLTF-like gene (GAS11; growth arrest-specific gene 11) is up-regulated in growth-arrested cells and is a candidate tumor suppressor (..
  2. Whitmore S, Settasatian C, Crawford J, Lower K, McCallum B, Seshadri R, et al. Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer. Genomics. 1998;52:325-31 pubmed
    ..This report describes the characterization of a transcript located in this region, the growth arrest-specific 11 (GAS11) gene, which was viewed as a potential tumor suppressor gene due to the expression of its mouse homolog ..
  3. Colantonio J, Bekker J, Kim S, Morrissey K, Crosbie R, Hill K. Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic. 2006;7:538-48 pubmed
    The mammalian GAS11 gene is a candidate tumor suppressor of unknown function that was previously identified as one of several genes upregulated upon growth arrest...
  4. Patoughi M, Ghafouri Fard S, Arsang Jang S, Taheri M. GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis. Immunobiology. 2019;: pubmed publisher
    ..6% accuracy in diagnosis of disease status in male subjects. The current study shows significance of GAS8 and GAS8-AS1 in the pathogenesis of MS and the putative role of GAS8-AS1 as a diagnostic biomarker in a subset of patients. ..
  5. Shen C, Zhang G, Qiu Z, Song H, Sun Z, Luo Q. Targeted next-generation sequencing in papillary thyroid carcinoma patients looking for germline variants predisposing to the disease. Endocrine. 2019;: pubmed publisher
    ..However, these results must be further verified and the potential biological functions of these germline variants in the pathogenesis of PTC remain to be determined in future studies. ..
  6. Chen N, Yin D, Lun B, Guo X. LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis. Biosci Rep. 2019;39: pubmed publisher
    ..In addition, we also proved that overexpressed GAS8-AS1 inhibited tumor formation in vivo GAS8-AS1 suppresses PTC cell growth through the miR-135b-5p/CCND2 axis. ..
  7. Pan W, Zhang N, Liu W, Liu J, Zhou L, Liu Y, et al. The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8. J Biol Chem. 2018;293:17154-17165 pubmed publisher
    ..Our results provide important insights into how lncRNA GAS8-AS1 suppresses HCC development and suggest potential strategies for treating patients with liver cancer. ..
  8. Basso T, Villacis R, Canto L, Alves V, Lapa R, Nóbrega A, et al. Genomic profile of a Li-Fraumeni-like syndrome patient with a 45,X/46,XX karyotype, presenting neither mutations in TP53 nor clinical stigmata of Turner syndrome. Cancer Genet. 2015;208:341-4 pubmed publisher
    ..Surprisingly, the patient presented with an apparently normal phenotype. The PRDM and GAS8 genes are potential candidates to be associated with the risk of developing cancer in this LFL/TS patient. ..
  9. Shapiro A, Leigh M. Value of transmission electron microscopy for primary ciliary dyskinesia diagnosis in the era of molecular medicine: Genetic defects with normal and non-diagnostic ciliary ultrastructure. Ultrastruct Pathol. 2017;41:373-385 pubmed publisher
    ..Clinicians must be aware of these genetic causes of PCD resulting in non-diagnostic TEM ciliary ultrastructure and refrain from using TEM of respiratory cilia as a test to rule out PCD. ..

More Information


  1. Qin Y, Sun W, Zhang H, Zhang P, Wang Z, Dong W, et al. LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer. Endocrine. 2018;59:555-564 pubmed publisher
    ..This provided a new experimental basis to explore the effects of lncRNA on autophagy in the treatment of thyroid cancer. ..
  2. Ali M, Zheng W, Sohail S, Li Q, Zheng W, Zhang H. A genetically enhanced sterile insect technique against the fruit fly, Bactrocera dorsalis (Hendel) by feeding adult double-stranded RNAs. Sci Rep. 2017;7:4063 pubmed publisher
    ..dorsalis flies. In short, this study provides an effective SIT technique for long-term B. dorsalis management. ..
  3. Hubert A, Henderson J, Cowles M, Ross K, Hagen M, Anderson C, et al. A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration. BMC Genomics. 2015;16:769 pubmed publisher
    ..We have additionally created an online database to house our in situ and RNAi data to make it accessible to the planarian research community. ..
  4. Yeh S, Chen Y, Chang A, Ray R, She B, Lee W, et al. Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. J Biol Chem. 2002;277:6311-7 pubmed
  5. Olbrich H, Cremers C, Loges N, Werner C, Nielsen K, Marthin J, et al. Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Am J Hum Genet. 2015;97:546-54 pubmed publisher
    ..Genome-wide exome sequence analyses identified recessive loss-of-function mutations in GAS8 encoding DRC4 in three independent PCD-affected families.
  6. Lewis W, Malarkey E, Tritschler D, Bower R, Pasek R, Porath J, et al. Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLoS Genet. 2016;12:e1006220 pubmed publisher
    ..GAS8 shares strong sequence similarity with the Chlamydomonas Nexin-Dynein Regulatory Complex (NDRC) protein 4 (DRC4) where it is needed for proper flagella motility...
  7. Nan H, Kraft P, Qureshi A, Guo Q, Chen C, Hankinson S, et al. Genome-wide association study of tanning phenotype in a population of European ancestry. J Invest Dermatol. 2009;129:2250-7 pubmed publisher
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color. ..
  8. Zhang D, Liu X, Wei B, Qiao G, Jiang T, Chen Z. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. Int J Endocrinol. 2017;2017:2645904 pubmed publisher
    ..746 in LNM prediction (P < 0.001). The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction. ..
  9. Bower R, Tritschler D, Mills K, Heuser T, Nicastro D, Porter M. DRC2/CCDC65 is a central hub for assembly of the nexin-dynein regulatory complex and other regulators of ciliary and flagellar motility. Mol Biol Cell. 2018;29:137-153 pubmed publisher
    ..Mutations in three subunits (DRC1, DRC2/CCDC65, DRC4/GAS8) have been linked to defects in ciliary motility in humans and lead to a ciliopathy known as primary ciliary ..
  10. Jeanson L, Thomas L, Copin B, Coste A, Sermet Gaudelus I, Dastot Le Moal F, et al. Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization. Hum Mutat. 2016;37:776-85 pubmed publisher
    ..mutations in GAS8, a gene that encodes a subunit of the nexin-dynein regulatory complex (N-DRC) orthologous to DRC4 of the flagellated alga Chlamydomonas reinhardtii...
  11. Zhao L, Xu L, Zhou X, Zhu Q, Yang Z, Zhang C, et al. Interaction of influenza virus NS1 protein with growth arrest-specific protein 8. Virol J. 2009;6:218 pubmed publisher
    ..Furthermore, actin and Gas8 co-localized at the plasma membrane. These results are discussed in relation to the possible functions of Gas8 protein and their relevance in influenza virus release...
  12. Ralston K, Hill K. Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. PLoS Pathog. 2006;2:e101 pubmed publisher
  13. Pan W, Zhou L, Ge M, Zhang B, Yang X, Xiong X, et al. Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations. Hum Mol Genet. 2016;25:1875-84 pubmed publisher
    ..6 × 10(-4)). Together our study defines a exome mutational spectrum of PTC in the Chinese population and highlights lncRNA GAS8-AS1 and LPAR4 as potential diagnostics and therapeutic targets. ..
  14. Evron T, Philipp M, Lu J, Meloni A, Burkhalter M, Chen W, et al. Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem. 2011;286:27676-86 pubmed publisher
    ..This is in contrast to cells stably expressing both GRK2 and Smo, in which cilia are significantly elongated. These results identify Gas8 as a positive regulator of Hh signaling that cooperates with GRK2 to control Smo signaling. ..