GRIA4

Summary

Gene Symbol: GRIA4
Description: glutamate receptor, ionotropic, AMPA 4
Alias: GLUR4, GLUR4C, GLURD, GluA4, AMPA-selective glutamate receptor 4, gluR-4, gluR-D, glutamate receptor 4, glutamate receptor, ionotrophic, AMPA 4
Species: human

Top Publications

  1. ncbi Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain
    Arja Pasternack
    Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, Viikinkaari 5, Helsinki FIN 00014, Finland
    J Biol Chem 277:49662-7. 2002
  2. ncbi Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4
    Mutsuo Nuriya
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 95:544-52. 2005
  3. ncbi Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein
    Sarah K Coleman
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland FIN 00014
    J Neurosci 23:798-806. 2003
  4. ncbi Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes
    B E Akinshola
    Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
    Brain Res Mol Brain Res 93:8-17. 2001
  5. ncbi Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL mice
    Jin Ping Zhang
    Institute of Neurosciences, The Fourth Military Medical University, Shaanxi, Xi an 710032, PR China
    Neurochem Int 49:319-26. 2006
  6. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
  7. ncbi In vitro classical conditioning of the turtle eyeblink reflex: approaching cellular mechanisms of acquisition
    Joyce Keifer
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57010, USA
    Cerebellum 2:55-61. 2003
  8. pmc N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression
    Jordan P Steinberg
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:18212-6. 2004
  9. doi Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-alpha-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats
    B K Eschle
    Department of Biology and Vermont Chemical Senses Group, 109 Carrigan Drive, University of Vermont, Burlington, VT 05405, USA
    Neuroscience 163:1292-301. 2009
  10. ncbi Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction
    Michael C Hanna
    The National Institute of Neurological Disorders and Stroke, National Institutes of Health, Cellular Neurology Unit, Bethesda, MD, USA
    Mol Vis 13:2194-208. 2007

Research Grants

  1. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2004
  2. Role of cGKII in AMPA Receptor Transport
    Edward B Ziff; Fiscal Year: 2010
  3. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    KENNA PEUSNER; Fiscal Year: 2007
  4. Gluthathione Depletion /Mitochondrial Complex I Dysfunct
    Julie Andersen; Fiscal Year: 2006
  5. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2010
  6. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2009
  7. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2006
  8. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2007
  9. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2009
  10. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003

Detail Information

Publications152 found, 100 shown here

  1. ncbi Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain
    Arja Pasternack
    Institute of Biotechnology, Viikki Biocenter, P O Box 56, University of Helsinki, Viikinkaari 5, Helsinki FIN 00014, Finland
    J Biol Chem 277:49662-7. 2002
    ..g. in the assembly of heteromeric receptors and in synaptic protein interactions...
  2. ncbi Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4
    Mutsuo Nuriya
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 95:544-52. 2005
    ..with AMPA receptors and regulate their function, little is known about the regulation of the AMPA receptor subunit GluR4. To understand the molecular mechanisms of GluR4 functional regulation, the yeast two-hybrid system was used to ..
  3. ncbi Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein
    Sarah K Coleman
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland FIN 00014
    J Neurosci 23:798-806. 2003
    ..1 family protein(s) plays an essential role in the transport to and stabilization of GluR-D-containing AMPA receptors at the cell surface...
  4. ncbi Involvement of non-NMDA receptors in the rescue of weaver cerebellar granule neurons and sensitivity to ethanol of cerebellar AMPA receptors in oocytes
    B E Akinshola
    Department of Pharmacology, Howard University College of Medicine, Suite 3408 NPG Adams Bldg, 520 W Street N W, Washington, DC 20059, USA
    Brain Res Mol Brain Res 93:8-17. 2001
    ..subunits GluR1-4 were detected from +/+ and wv/wv cerebella, and by immunocytochemistry, GluR1, GluR2/3 and GluR4 were observed to be expressed in cultured +/+ and wv/wv granule cells...
  5. ncbi Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL mice
    Jin Ping Zhang
    Institute of Neurosciences, The Fourth Military Medical University, Shaanxi, Xi an 710032, PR China
    Neurochem Int 49:319-26. 2006
    ..The percentages of AMPA receptor subunits co-localizing in SPR-positive neurons were GluR4 (48%), GluR1 (47%), GluR2 (26%) and GluR3 (20%), respectively...
  6. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
    ..In tests with recombinantly expressed AMPA receptor subunits, D1 preferred the glutamate receptor (GluR) subunit GluR4 flip (0.64 microM) over GluR4 flop (5...
  7. ncbi In vitro classical conditioning of the turtle eyeblink reflex: approaching cellular mechanisms of acquisition
    Joyce Keifer
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57010, USA
    Cerebellum 2:55-61. 2003
    ..mechanisms are required to generate CRs and that the level of conditioning is associated with the upregulation of GluR4-containing AMPA receptors in the abducens motor nuclei...
  8. pmc N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression
    Jordan P Steinberg
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:18212-6. 2004
    ..The sequence of the GluR2 subunit is similar to that of the GluR3 and GluR4c subunits, which also contain PDZ ligands and protein kinase C consensus sites...
  9. doi Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-alpha-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats
    B K Eschle
    Department of Biology and Vermont Chemical Senses Group, 109 Carrigan Drive, University of Vermont, Burlington, VT 05405, USA
    Neuroscience 163:1292-301. 2009
    ..These findings suggest that multiple receptors are involved in amino acid taste and that taste-mGluR4 receptors contribute to the taste of MSG and at least some l-amino acids...
  10. ncbi Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction
    Michael C Hanna
    The National Institute of Neurological Disorders and Stroke, National Institutes of Health, Cellular Neurology Unit, Bethesda, MD, USA
    Mol Vis 13:2194-208. 2007
    ..Here we apply the same protocol to compare expression of these genes in cDNA constructed from single rod and cone bipolar cells previously-labeled for morphological identification in fixed slices of macaque retina...
  11. ncbi Effect of photoreceptor degeneration on RNA splicing and expression of AMPA receptors
    Kazuhiko Namekata
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Mol Vis 12:1586-93. 2006
    ..This study was conducted to examine the developmental progression of the flip-to-flop alternative splicing switch of AMPA receptors in wild-type and rd mouse retina...
  12. ncbi Distribution of AMPA receptor subunits GluR1-4 in the dorsal vagal complex of the rat: a light and electron microscope immunocytochemical study
    J P Kessler
    Laboratoire de Neurobiologie, UPR 9024, Centre National de la Recherche Scientifique, 31, chem Joseph Aiguier, F13402 Marseille cx 20, France
    Synapse 34:55-67. 1999
    ..within this region was investigated using immunohistochemistry and antibodies recognizing either one (GluR1 or GluR4) or two (GluR2 and GluR3) AMPA receptors subunits...
  13. ncbi The effects of willed movement therapy on AMPA receptor properties for adult rat following focal cerebral ischemia
    Qingping Tang
    Department of Neurology, Xiang Ya Hospital, Central South University, Changsha 410008, Hunan, China
    Behav Brain Res 181:254-61. 2007
    ....
  14. pmc PKA has a critical role in synaptic delivery of GluR1- and GluR4-containing AMPARs during initial stages of acquisition of in vitro classical conditioning
    Zhaoqing Zheng
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    J Neurophysiol 101:2539-49. 2009
    ..role in initiating a signaling cascade that results in synaptic delivery of glutamate receptor 1 (GluR1)- and GluR4-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in abducens motor neurons ..
  15. ncbi Expression of the AMPA-selective receptor subunits in the vestibular nuclei of the chinchilla
    P Popper
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90024 1624, USA
    Brain Res Mol Brain Res 44:21-30. 1997
    ..used to localize the messenger RNAs and proteins of the AMPA-selective receptor subunits GluR1, GluR2, GluR3 and GluR4 in the vestibular nuclei of the chinchilla...
  16. ncbi Altered glutamate and GABA release within thalamocortical circuitry in metabotropic glutamate receptor 4 knockout mice
    X Wang
    Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada
    Neuroscience 134:1195-203. 2005
    The metabotropic glutamate receptor 4 is highly expressed presynaptically on thalamocortical neurons that are involved in the pathogenesis of generalized absence seizures...
  17. ncbi Primary afferent terminals in spinal cord express presynaptic AMPA receptors
    Chun Rong Lu
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 22:9522-9. 2002
    ..for the C terminus of glutamate receptor subunit 2 (GluR2) and GluR3 (GluR2/3) rather than by an antibody for GluR4. In dorsal roots, anti-GluR2/3 stains predominantly myelinated fibers; anti-GluR4 or anti-GluR2/4 stains ..
  18. ncbi Conversion of silent synapses into the active pool by selective GluR1-3 and GluR4 AMPAR trafficking during in vitro classical conditioning
    Maxim Mokin
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    J Neurophysiol 98:1278-86. 2007
    ..Later in conditioning, levels of GluR1-3 declined and enhanced colocalization of GluR4-containing AMPAR subunits at synapses was observed...
  19. ncbi Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors
    Ko Zushida
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    J Neurosci 27:158-66. 2007
    ..Quantitative PCR studies suggested the pronounced expression of PEPA-preferring AMPA receptor subunits (GluR3 and GluR4) and a splice variant (flop) in the mPFC...
  20. ncbi Localization of ionotropic and metabotropic glutamate receptors in distinct neuronal elements of the rat substantia nigra
    K K Yung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, China
    Neurochem Int 33:313-26. 1998
    ..using commercially available antibodies (against subunits of ionotropic glutamate receptors: GluR1, GluR2/3, GluR4, NMDAR1, NMDAR2A/B; and subtypes of metabotropic glutamate receptors: mGluR1alpha, mGluR2/3)...
  21. ncbi Neurochemistry of the mammalian cone 'synaptic complex'
    N Vardi
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104 6058, USA
    Vision Res 38:1359-69. 1998
    ..Surprisingly, invaginating bipolar dendrites in the cat also express the AMPA receptor subunits, GluR2/3 and GluR4. (ii) Dendrites forming basal contacts in the cat (probably OFF) express the AMPA subunits GluR2/3, GluR4, and ..
  22. pmc Oligomeric amyloid-{beta} inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning
    Zhaoqing Zheng
    From the Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota, Sanford School of Medicine, Vermillion, South Dakota 57069
    J Biol Chem 285:34708-17. 2010
    ..imaging indicate that oligomeric Aβ, but not fibrillar or scrambled forms, suppresses colocalization of GluR1 and GluR4 AMPA receptor subunits with synaptophysin, indicating that trafficking of these subunits to synapses during the ..
  23. ncbi Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb
    A A Montague
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 405:233-46. 1999
    ..to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunits: GluR1, GluR2/3, and GluR4; and kainate (KA) receptor subunits: GluR5/6/7...
  24. pmc Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors
    Erika Polgár
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Neurosci 28:13150-60. 2008
    ..Unlike most glutamatergic synapses in superficial laminas, those on the gephyrin-coated cells contain the GluR4 subunit of the AMPA receptor...
  25. ncbi Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators
    Markus Kessler
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 N Rutledge, PO Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1076:25-41. 2006
    ..One potential limitation of [3H]FW is a large preference for subunits GluR1 and GluR2 (KD 4-10 nM) over GluR3 and GluR4 (160-600 nM) which implies that tests with brain membranes preferentially reveal drug effects produced at the ..
  26. ncbi Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles
    D Bleakman
    Eli Lilly and Co, Lilly Research Centre, Windlesham, Surrey, U K
    Neuropharmacology 35:1689-702. 1996
    ..IC50 values of 18 microM, 24 microM and 6 microM, respectively and AMPA (10 microM) responses in recombinant human GluR4 expressing HEK293 cells with approximate IC50 values of 22 microM, 28 microM and 5 microM, respectively...
  27. ncbi Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the cat
    R Ambalavanar
    Voice and Speech Section, NIDCD, NIH, Bethesda, Maryland 20892 1416, USA
    J Comp Neurol 402:75-92. 1998
    ..alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR1, GluR2/3, GluR4) and the N-methyl-D-aspartate (NMDA) receptor subunit NR1 in the cat caudal brainstem was investigated by using ..
  28. pmc Ionotropic glutamate receptor expression in preganglionic neurons of the rat inferior salivatory nucleus
    M Kim
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, United States
    Auton Neurosci 138:83-90. 2008
    ..antibodies to glutamate receptor subunits NR1, NR2A, NR2B, (NMDA receptor subunits) GluR1, GluR2, GluR3, GluR4 (AMPA receptor subunits), and GluR5-7, KA2 (kainate receptor subunits) to determine their expression in ISN ..
  29. ncbi Quantitative analysis of immunofluorescent punctate staining of synaptically localized proteins using confocal microscopy and stereology
    Maxim Mokin
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57069, USA
    J Neurosci Methods 157:218-24. 2006
    ..Triple-labeling of the presynaptic marker synaptophysin, the NR1 subunit of NMDA receptors, and the GluR4 subunit of AMPA receptors was performed on pseudoconditioned (control) and conditioned in vitro brain stem ..
  30. ncbi Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: effect on GluR4 phosphorylation and surface expression
    André R Gomes
    Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    J Neurochem 90:673-82. 2004
    ..kinase A (PKA) can phosphorylate the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR4 on Ser842, both in vitro and in vivo...
  31. ncbi Comparative distribution of glutamate transporters and receptors in relation to afferent innervation density in the mammalian cochlea
    David N Furness
    MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom
    J Neurosci 23:11296-304. 2003
    ..or excitatory amino acid transporter 1), vesicular glutamate transporter (VGLUT1), and the AMPA receptor glutamate receptor 4 (GluR4) along the spiral...
  32. ncbi Activity regulates the expression of AMPA receptor subunit GluR4 in developing visual cortex
    Yukio Akaneya
    Division of Neurophysiology, Department of Neuroscience, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Japan
    Eur J Neurosci 25:1641-6. 2007
    ..visual cortex, the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit GluR4 precedes that of the other AMPAR subunits GluR1-3, and then declines to become almost absent in adults...
  33. pmc Glutamate receptor subunit expression in the rhesus macaque locus coeruleus
    Nigel C Noriega
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1173:53-65. 2007
    ..histological findings and showed expression of mRNA encoding ionotropic glutamate receptor subunits NR2A, NR2D, GluR4, and GluR6, as well as the metabotropic glutamate receptor subunits mGluR1, mGluR3, mGluR4, mGluR5, and mGluR7...
  34. ncbi Phosphorylation of GluR4 AMPA-type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons
    Ana Luisa Carvalho
    Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Eur J Neurosci 15:465-74. 2002
    ..1998). In this study, we evaluated the phosphorylation of the GluR4 subunit, which is very abundant in cultured amacrine neurons, to correlate it with the effects of PKC on AMPA ..
  35. pmc Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits
    Andrew J Todd
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Neurosci 29:718-26. 2009
    ..b>GluR4 can be alternatively spliced such that it has a long or short cytoplasmic tail...
  36. ncbi [3H]CNQX and NMDA-sensitive [3H]glutamate binding sites and AMPA receptor subunit RNA transcripts in the striatum of normal and weaver mutant mice and effects of ventral mesencephalic grafts
    A Mitsacos
    Department of Physiology, Faculty of Medicine, School of Biological Sciences, University of Patras, Greece
    Cell Transplant 8:11-23. 1999
    ..the striatum are seen with a decreasing signal intensity in the following order: GluRB > GluRA > GluRC > GluRD. The weaver caudate-putamen shows a 12% increase in GluRA subunit mRNA compared to +/+, whereas mesencephalic ..
  37. ncbi Recent advances in the study of AMPA receptors
    Takeshi Suzuki
    Department of Pharmacology, Kyoritsu College of Pharmacy, Tokyo, Japan
    Nihon Yakurigaku Zasshi 122:515-26. 2003
    ..AMPA receptors are cation-conducting complexes composed of various combinations of four subunits (GluR1 to GluR4)...
  38. ncbi Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development
    Jessica Douyard
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 062693156, USA
    J Comp Neurol 502:141-56. 2007
    ..In contrast, GluR2/3 and GluR4 AMPAR subunits were stably expressed in both Purkinje cells (GluR2/3) and Bergmann glia (GluR4) throughout ..
  39. ncbi Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain
    Monica Beneyto
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Comp Neurol 468:530-54. 2004
    ..Using in situ hybridization, we examined the expression of transcripts encoding the AMPA receptor subunits (GluR1-GluR4) and a family of AMPA-related intracellular proteins...
  40. ncbi Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear
    M Knipper
    Tübingen Centre for Hearing Research, Laboratory of Biochemistry, Department of Otolaryngology, University of Tubingen, Röntgenweg 11, D 72076 Tubingen, Germany
    Cell Tissue Res 287:23-41. 1997
    ..During the following 2 weeks, GluR2/3 receptors were downregulated in exchange for GluR4 receptors...
  41. ncbi Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity
    John Q Wang
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, USA
    Mol Neurobiol 32:237-49. 2005
    ..and cultured neurons have shown that the AMPA receptor can be phosphorylated on their subunits (GluR1, GluR2, and GluR4). All phosphorylation sites reside at serine, threonine, or tyrosine on the intracellular C-terminal domain...
  42. ncbi Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons
    Michel Eybalin
    INSERM U583, Institut des Neurosciences, Hopital St Eloi, 80, avenue Augustin Fliche, BP 74103, 34091 Montpellier Cedex 5, France
    Eur J Neurosci 20:2981-9. 2004
    ..GluR2 immunoreactivity was not detected until PND10 and GluR3 and GluR4 immunoreactivities were detected at all the ages examined...
  43. ncbi Cellular localization of AMPA type glutamate receptor subunits in the basal ganglia of pigeons (Columba livia)
    Antonio V Laverghetta
    Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN 38163, USA
    Brain Behav Evol 67:10-38. 2006
    ..Parvalbuminergic and calretininergic striatal interneurons were rich in GluR1 and GluR4, a few cholinergic striatal interneurons possessed GluR2, but somatostatinergic striatal interneurons were devoid ..
  44. pmc Glutamate Receptors GluR1 and GluR4 in the Hamster Superior Colliculus: Distribution and Co-localization with Calcium-Binding Proteins and GABA
    Jae Sik Choi
    Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, South Korea
    Acta Histochem Cytochem 42:29-38. 2009
    We investigated the distributions of AMPA glutamate receptor subtypes GluR1 and GluR4 in the hamster superior colliculus (SC) with antibody immunocytochemistry and the effect of enucleation on these distributions...
  45. ncbi A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans
    Akiko Muroyama
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Diabetes 53:1743-53. 2004
    ..In this study, we showed that delta-cells express GluR4c-flip, a newly identified splicing variant of GluR4, an (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic ..
  46. ncbi Localization of ionotropic glutamate receptors to invaginating dendrites at the cone synapse in primate retina
    David J Calkins
    Department of Ophthalmology and Visual Sciences, The Vanderbilt Eye Institute and Vanderbilt Vision Research Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Vis Neurosci 22:469-77. 2005
    ..for electron microscopy, we quantified the distribution of the AMPA-sensitive subunits GluR2/3 and GluR4 and of the kainate-sensitive subunits GluR6/7 across 207 labeled dendrites occupying specific morphological loci ..
  47. pmc How do tonic glutamatergic synapses evade receptor desensitization?
    Ji Jie Pang
    Cullen Eye Institute, Baylor College of Medicine, One Baylor Plaza, NC 205, Houston, TX 77030, USA
    J Physiol 586:2889-902. 2008
    ..ribbon junctions as releasing sites for low-frequency, synchronized multiquantal release at each site; and (2) the GluR4 AMPA receptors as the postsynaptic receptors...
  48. ncbi Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus
    R S Petralia
    Laboratory of Neurochemistry, NIDCD, NIH, Bethesda, Maryland 20892, USA
    J Comp Neurol 372:356-83. 1996
    ..receptors was examined with preembedding immunocytochemistry, using 14 antibodies to ionotropic (GluR1, GluR2/3, GluR4, GluR5-7, GluR6/7, KA2, NR1, NR2A/B, delta 1/2) and metabotropic (mGluR1 alpha, mGluR2/3, mGluR5) glutamate ..
  49. doi Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization
    Daoliang Lan
    College of Life Science and Technology, Southwest University for Nationality, Chengdu, People s Republic of China
    Avian Pathol 39:151-9. 2010
    ..on the best known function of their protein products, which involved signalling transduction (HSPC166, PDE7B, GRIA4, GARNL1), transcriptional regulation (ANP32A, LOC423724, SATB1, QKI, ETV6), cellular molecular dynamics (MYLK, ..
  50. pmc The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation
    Jesper Mosolff Mathiesen
    Department of Molecular Pharmacology, H Lundbeck A S, DK 2500 Valby, Denmark
    Br J Pharmacol 148:279-90. 2006
    1. The metabotropic glutamate receptor 4 (mGluR4) is a Galphai-coupled receptor that modulates glutamatergic neurotransmission...
  51. ncbi Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS
    C Corti
    Cambridge Brain Bank Laboratory, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroscience 110:403-20. 2002
    ..In addition, the question of alternatively spliced mGluR4 isoforms is discussed...
  52. ncbi Glutamate receptors in pediatric tumors of the central nervous system
    Katja S Brocke
    Department of Pediatric Neurology, University Hospital Carl Gustav Carus, Children s Hospital, University of Technology Dresden, Dresden, Germany
    Cancer Biol Ther 9:455-68. 2010
    ..We examined expression of NMDA receptor subunits NR1-NR3B, AMPA receptor subunits GluR1-GluR4, kainate receptor subunits GluR5-GluR7, KA1, KA2 and metabotropic receptor subunits mGluR1-8...
  53. ncbi Identifications, classification, and evolution of the vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes
    Y C Chen
    Department of Life Science, National Tsing Hua University, 101, Sec 2, Kang Fu Road, Hsinchu, Taiwan 30043, Republic of China
    J Mol Evol 53:690-702. 2001
    ..Mammalian and avian AMPARs are assembled from the products of four genes (GRIA1-GRIA4) conserved in their translated sequences and gene organizations...
  54. ncbi Differential postsynaptic distribution of GluRs 1-4 on cartwheel and octopus cell somata in the gerbil cochlear nucleus
    I R Schwartz
    Section of Otolaryngology, Yale University School of Medicine, P O Box 208041, New Haven, CT 06520 8041, USA
    Hear Res 147:70-6. 2000
    ..which confers calcium impermeability to the assembled receptor and slower gating kinetics to receptors with a high GluR4 content, is the major difference in the AMPA receptors on the somata of these cell types...
  55. ncbi Rat gustatory neurons in the geniculate ganglion express glutamate receptor subunits
    Alejandro Caicedo
    Department of Ophthalmology, University of Miami School of Medicine, 1638 NW 10th Avenue, William L McKnight Vision Research Center, Miami, FL 33136, USA
    Chem Senses 29:463-71. 2004
    ..AMPA and NMDA type subunits were immunohistochemically detected with antibodies against GluR1, GluR2, GluR2/3, GluR4 and NR1 subunits...
  56. doi Noggin and Sonic hedgehog are involved in compensatory changes within the motoneuron-depleted mouse spinal cord
    Rosario Gulino
    Department of Bio Medical Sciences, Section of Physiology, University of Catania, Viale Andrea Doria 6, Catania, Italy
    J Neurol Sci 332:102-9. 2013
    ..of Sonic hedgehog, Noggin, Choline Acetyltransferase, Synapsin-I and Glutamate receptor subunits (GluR1, GluR2, GluR4), in a motoneuron-depleted mouse spinal cord lesion model obtained by intramuscular injection of Cholera toxin-B ..
  57. ncbi Differential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of rats
    H J Hu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, PR China
    Neurosci Res 49:281-8. 2004
    ..except of GluR3)-immunoreactivity were observed: all (100%) of SPR-positive neurons displayed GluR1-, GluR2- or GluR4-immunoreactivity, and the double-labeled neurons constituted about 33, 3 or 29% of total GluR-positive ones...
  58. pmc Pannexin1 stabilizes synaptic plasticity and is needed for learning
    Nora Prochnow
    Neuroanatomy, Medical Faculty, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e51767. 2012
    ..Compensatory transcriptional up-regulation of metabotropic glutamate receptor 4 (grm4) accompanies these adaptive changes...
  59. ncbi Ionotropic glutamate receptor subunit immunoreactivity of vagal preganglionic neurones projecting to the rat heart
    Eric K A Corbett
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, LS2 9JT, Leeds, UK
    Auton Neurosci 105:105-17. 2003
    ..was weak or absent, while labelling with antibodies directed to GluR2, a common sequence of GluR2 and GluR3, and GluR4 was moderate or intense...
  60. ncbi The DNA damaging agent etoposide activates a cell survival pathway involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors and mitogen-activated protein kinases in hippocampal neurons
    Chengbiao Lu
    Laboratory of Neurosciences, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neurosci Res 70:671-9. 2002
    ..with the increase in AMPA-induced current was an increase in the amounts of AMPA receptor subunits GluR1 and GluR4, whereas levels of the NMDA receptor subunit NR1 were unaffected by etoposide...
  61. ncbi Development of glutamatergic synapses in the rat retina: the postnatal expression of ionotropic glutamate receptor subunits
    Iris Hack
    Max Planck Institut für Hirnforschung, Abteilung fur Neuroanatomie, Frankfurt am Main, Germany
    Vis Neurosci 19:1-13. 2002
    We examined the distribution of the AMPA glutamate receptor subunits GluR1 to GluR4, of the kainate receptor subunits GluR6/7 and KA2, and of the glutamate receptor subunits delta1/2, during postnatal development of the rat retina by ..
  62. ncbi Glutamate receptors at rod bipolar ribbon synapses in the rabbit retina
    Wei Li
    Department of Ophthalmology and Visual Science, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
    J Comp Neurol 448:230-48. 2002
    ..In summary, GluR2/3 and GluR4 are expressed by AII amacrine cells but not by S1/S2 amacrine cells...
  63. ncbi Synaptic distribution of ionotropic glutamate receptors in the inner plexiform layer of the primate retina
    Ulrike Grünert
    Department of Physiology F13, University of Sydney, Sydney, New South Wales 2006, Australia
    J Comp Neurol 447:138-51. 2002
    ..Immunoreactive GluR2, GluR2/3, and GluR4 puncta were found at high density throughout the IPL and are probably expressed at every dyad...
  64. pmc Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP
    Jesper Mosolff Mathiesen
    Division of Biological Research, Department of Molecular Pharmacology, H Lundbeck A S, DK 2500 Valby, Denmark
    Br J Pharmacol 138:1026-30. 2003
    ..Finally, SIB-1893 and MPEP failed to displace [(3)H]L-AP4 binding. Taken together, these data identify positive allosteric modulators for the hmGluR4...
  65. ncbi Targeting of GLUR4-containing AMPA receptors to synaptic sites during in vitro classical conditioning
    M Mokin
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 East Clark Street, Vermillion 57069, USA
    Neuroscience 128:219-28. 2004
    The synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning of a neural correlate of an eyeblink response was examined by fluorescence imaging of punctate staining for glutamate receptor subunits and ..
  66. ncbi Immediate-early gene-encoded protein Arc is associated with synaptic delivery of GluR4-containing AMPA receptors during in vitro classical conditioning
    Maxim Mokin
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    J Neurophysiol 95:215-24. 2006
    ..during conditioned response (CR) acquisition, there is significantly greater colocalization of Arc protein and GluR4-containing AMPA receptors at synaptic sites, however, colocalization of Arc and GluR4 was not observed after later ..
  67. ncbi Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies
    Armando J Cristóvão
    Department of Zoology, Centre for Neuroscience of Coimbra, University of Coimbra, 3004 517 Coimbra Codex, Portugal
    Int J Dev Neurosci 20:1-9. 2002
    ..in response to AMPA, kainate or to L-glutamate, and the expression of the receptor subunits GluR1, GluR2/3, GluR4 and GluR6/7 was determined in the retinospheroids and in chick retinas by immunodetection using polyclonal ..
  68. ncbi Repeated administration of amphetamine or cocaine does not alter AMPA receptor subunit expression in the rat midbrain
    Wenxiao Lu
    Department of Neuroscience, FUHS The Chicago Medical School, North Chicago, IL 60064 3095, USA
    Neuropsychopharmacology 26:1-13. 2002
    ..Immunolabeling for GluR1, GluR2, GluR2/3, and GluR4 was quantified by immunohistochemistry with 35S-labeled secondary antibodies in VTA, substantia nigra, and a ..
  69. doi Investigation of possible epistatic interactions between GRIA2 and GRIA4 variants on clinical outcomes in patients with major depressive disorder
    Alberto Chiesa
    Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
    J Int Med Res 41:809-15. 2013
    ..propionate (AMPA) 2 (GRIA2) rs4260586 and glutamate receptor, ionotropic, AMPA 4 (GRIA4) rs10736648 single nucleotide polymorphisms (SNPs) on response to antidepressants in Korean patients with major ..
  70. ncbi Synaptic plasticity and functionality at the cone terminal of the developing zebrafish retina
    Oliver Biehlmaier
    Department for Experimental Ophthalmology, University Eye Hospital, Roentgenweg 11, 72076 Tuebingen, Germany
    J Neurobiol 56:222-36. 2003
    ..microscopy, and the maturation of photoreceptor downstream connection was identified by immunocytochemistry for GluR4 (AMPA-type glutamate receptor subunit), protein kinase beta(1) (mixed rod-cone bipolar cells), and tyrosine ..
  71. ncbi Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation
    Susana Santos Correia
    Center for Neuroscience and Cell Biology and Department of Biochemistry, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 278:6307-13. 2003
    ..In the present study we investigated the association of protein kinase C (PKC) gamma isoform with the GluR4 AMPA receptor subunit...
  72. doi 4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators
    Hermogenes N Jimenez
    Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA
    Bioorg Med Chem Lett 22:3235-9. 2012
    ..In spite of the excellent ligand efficiency of 1 (LE=0.43), optimization of in vitro potency for this series reached a plateau around EC(50)=200 nM...
  73. pmc Ionotropic glutamate receptors mediate OFF responses in light-adapted ON bipolar cells
    Ji Jie Pang
    Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, United States
    Vision Res 68:48-58. 2012
    ..the sign-inverting, depolarizing light responses, subpopulations of cone-dominated and rod/cone mixed DBCs use GluR4 AMPA receptors to generate a transient sign-preserving OFF response under light adapted conditions...
  74. doi Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders
    Sylvain Celanire
    Medicinal Chemistry Department, Addex Pharmaceuticals, Geneva, Switzerland
    Expert Opin Drug Discov 7:261-80. 2012
    ..Activation of mGluR4 with orthosteric agonists, allosteric agonists or pure positive allosteric modulators (PAM) has been postulated to be of broad therapeutic use...
  75. doi Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus
    Eva Martisova
    Department of Pharmacology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Neuropharmacology 62:1944-53. 2012
    ..Glutamate receptor subunits NR1 and NR2A and GluR4 were upregulated in stressed rats, and this effect was reversed by venlafaxine...
  76. ncbi [Expression of metabotropic glutamate receptor 4 in cardiomyocytes differentiated from mouse embryonic stem cells in vitro]
    Bei Zheng
    Institute of Pharmacology, Toxicology, and Biochemical Pharmaceutics, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 41:366-72. 2012
    To investigate the expression of metabotropic glutamate receptor 4 (mGluR4) in cardiomyocytes differentiated from mouse embryonic stem cells (ES cells).
  77. doi Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder
    Alberto Chiesa
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Eur Arch Psychiatry Clin Neurosci 262:305-11. 2012
    The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean ..
  78. ncbi AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus
    G Seifert
    Institute of Physiology, Department of Neurophysiology, Friedrich Schiller University Jena, Germany
    Brain Res Mol Brain Res 47:286-94. 1997
    ..Most frequently, we met co-expression of GluR2 and GluR4. This study demonstrates that astrocytes in the hippocampus express a distinct AMPA-R subunit composition which ..
  79. ncbi New isoforms of the chick glutamate receptor subunit GluR4: molecular cloning, regional expression and developmental analysis
    A Ravindranathan
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132, USA
    Brain Res Mol Brain Res 50:143-53. 1997
    ..We report here the cloning of three novel chick GluR4 isoforms. GluR4c has a 113-bp insert in the C-terminus, is expressed in flip and flop isoforms, is most strongly expressed in the ..
  80. doi Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration
    Suk King Lai
    Department of Physiology, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
    Eur J Neurosci 28:2157-72. 2008
    ..For Fos-labeled neurons expressing the GluR2, GluR2/3, GluR4 or NR2B subunit, a significant decrease was found by the adult stage...
  81. pmc BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK
    Wei Li
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark Street, Vermillion, SD 57069, USA
    Neurobiol Learn Mem 91:243-9. 2009
    ..Bath application of BDNF alone induces synaptic delivery of GluR1- and GluR4-containing AMPARs that is blocked by coapplication of the receptor tyrosine kinase inhibitor K252a...
  82. pmc Immunocytochemical analysis of photoreceptors in the tiger salamander retina
    Jian Zhang
    Cullen Eye Institute, Baylor College of Medicine, One Baylor Plaza, NC 205, Houston, TX 77030, USA
    Vision Res 49:64-73. 2009
    ..between rods/cones and bipolar/horizontal cells and the wide distribution of AMPA receptor subunits GluR2/3 and GluR4 at the rod/cone synapses were observed...
  83. doi Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey
    Howard S Ying
    Ophthalmology, The Johns Hopkins University Wilmer Eye Institute, Baltimore, MD, USA
    Prog Brain Res 171:13-6. 2008
    ..Sections were then stained for various neurotransmitter-signalling markers. MIF motoneurons showed less glutamate receptor 4 (GluR4) and N-methyl-D-aspartate receptor 1 (NMDAR1) immunoreactivity, but showed similar amounts of ..
  84. pmc Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity
    Daria A Chudakova
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 283:28806-16. 2008
    ..association of alpha(v)beta(3) integrin-Lyn kinase complex with ionotropic glutamate receptor subunits, GluR2 and GluR4, after cerebral IR...
  85. pmc Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
    Hailan Hu
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 28:7847-62. 2008
    ..In FMR1 knock-out mice, synaptic delivery of GluR1-, but not GluR2L- and GluR4-containing AMPA-Rs is impaired, resulting in a selective loss of GluR1-dependent long-term synaptic potentiation (..
  86. doi Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study
    C Lavedan
    Vanda Pharmaceuticals Inc, Rockville, MD 20850, USA
    Mol Psychiatry 14:804-19. 2009
    ..family, member 4 gene (XKR4), the tenascin-R gene (TNR), the glutamate receptor, inotropic, AMPA 4 gene (GRIA4), the glial cell line-derived neurotrophic factor receptor-alpha2 gene (GFRA2), and the NUDT9P1 pseudogene located ..
  87. pmc Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Brain Res 1214:23-34. 2008
    ..GluR1-4 subunits of the AMPA receptor; GluR5-7 and KA1-2 subunits of the kainate receptor; PSD95), all but two (GluR4 and KA1) were expressed at quantifiable levels...
  88. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  89. doi Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation
    Susana S Correia
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, Michigan 48109 0632, USA
    Nat Neurosci 11:457-66. 2008
    ..In summary, we identified the specific motor protein and organelle acceptor that catalyze the directional transport of AMPARs into spines during activity-dependent synaptic plasticity...
  90. doi Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina
    Ana R Santiago
    Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    Brain Res 1198:153-9. 2008
    ..the ionotropic alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) receptor subunits GluR1, GluR2, GluR4, and against the N-methyl-d-aspartate glutamate receptor subunit NR1...
  91. pmc Activity level-dependent synapse-specific AMPA receptor trafficking regulates transmission kinetics
    J Julius Zhu
    Departments of Pharmacology and Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 29:6320-35. 2009
    ..b>GluR4-containing AMPA-Rs traffic more heavily into thalamocortical synapses than intracortical synapses, and this ..
  92. ncbi Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster
    Y Matsuda
    Genome Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, 263, Japan
    Genomics 34:347-52. 1996
    ..and Atm-Npat-Acat1 and that the inversion of MMU9 originated from the chromosomal breakage at the boundary between Gria4 and Atm-Npat-Acat1 on HSA11...
  93. doi Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacogenet Genomics 21:206-16. 2011
    ..The glutamatergic system may be relevant to the pathophysiology of psychosis and to the effects of antipsychotic treatments...
  94. doi Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems
    Joanna M Wieronska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Neuropharmacology 59:627-34. 2010
    ..Moreover, the compound was not effective in 5-HT depleted animals. The results of these studies indicate that the GABAergic and serotonergic systems are involved in the potential anxiolytic action of LSP1-2111...
  95. ncbi Transmembrane topology of the glutamate receptor subunit GluR6
    K W Roche
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 269:11679-82. 1994
    ..Combining these results with other recent data, we have proposed an alternative transmembrane topology model...
  96. pmc Immunohistochemical localization of AMPA-type glutamate receptor subunits in the striatum of rhesus monkey
    Yun Ping Deng
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Brain Res 1344:104-23. 2010
    ..5% possessed GluR4. All neurons the large size of cholinergic interneurons (mean diameter 26...
  97. doi Dopamine D1 receptor blockage potentiates AMPA-stimulated luteinising hormone release in the goldfish
    J T Popesku
    Centre for Advanced Research in Environmental Genomics CAREG, Department of Biology, University of Ottawa, Ottawa, Canada
    J Neuroendocrinol 23:302-9. 2011
    ..Real-time reverse transcriptase-polymerase chain reaction identified the mRNAs for ionotropic (Gria2a, Gria4) glutamate receptor subunits, activin βa, isotocin, and cGnRH-II as being significantly affected by some of the ..
  98. doi Immunohistochemical localization of AMPA-type glutamate receptor subunits in the nucleus of the Edinger-Westphal in embryonic chick
    Claudio A B Toledo
    Núcleo de Pesquisa em Neurociências, Universidade Cidade de São Paulo, 03071 000, Sao Paulo, SP, Brazil
    Neurosci Lett 498:199-203. 2011
    ..Of the three antibodies used, one recognized the GluR1 subunit, another the GluR4 subunit, and the third recognized a sequence common to GluR2 and GluR3 subunits...
  99. doi Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis
    Hiltrud Muhle
    Department of Neuropediatrics, University Hospital of Kiel, Schwanenweg 20, 24105 Kiel, Germany
    Epilepsy Res 89:319-26. 2010
    GRM4 encoding the group III metabotropic glutamate receptor 4 (mGluR4), is located on the chromosomal segment 6p21...
  100. doi mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455
    Stephen P East
    Evotec UK Ltd, 114 Milton Park, Abingdon, OX14 4SA, UK
    Expert Opin Ther Pat 20:441-5. 2010
    Stimulation of the metabotropic glutamate receptor 4 (mGluR4) represents a promising new approach to the symptomatic treatment of the neurodegenerative disorder Parkinson's disease (PD)...
  101. ncbi Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
    Shogo Ishiuchi
    Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Nat Med 8:971-8. 2002
    ..AMPA)-type glutamate receptors assembled from the GluR1 and/or GluR4 subunits, and that their conversion to Ca(2+)-impermeable receptors by adenovirus-mediated transfer of the GluR2 ..

Research Grants71

  1. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2004
    ..The approach to the problem will be multi-disciplinary, employing physiological, pharmacological, anatomical, molecular and behavioral experimental approaches. ..
  2. Role of cGKII in AMPA Receptor Transport
    Edward B Ziff; Fiscal Year: 2010
    ..Aim 3. To study the cGKII regulated trafficking of GluR4 and GluR2L...
  3. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    KENNA PEUSNER; Fiscal Year: 2007
    ..tangential principal cells, and immunocytochemical studies of AMPA receptor subunits (GluR1, GluR2, GluR2/3, GluR4), potassium (Kv1.1, Kv1...
  4. Gluthathione Depletion /Mitochondrial Complex I Dysfunct
    Julie Andersen; Fiscal Year: 2006
    ..in glutathione in our cell model also results in inhibition of the GSSG reducing enzyme glutathione reductase (GluRd) and up-regulation of the enzyme g-glutamyl transpeptidase (GGT) which breaks down extracellular GSH to substrates ..
  5. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2010
    ..delivery of GluR1-containing AMPARs initially activate silent synapses, followed by synaptic incorporation GluR4 subunits that support the acquisition of CRs...
  6. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2009
    ..For research focused on the changes to neural function induced by chronic social stress during adolescence, and to direct pharmacotherapy of associated psychiatric disorders. ..
  7. NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR
    Joyce Keifer; Fiscal Year: 2006
    ..abstract_text> ..
  8. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2007
    ..The insights gained into basic processes of learning and memory will have fundamental implications for understanding memory disorders such as occur in amnesia and Alzheimer's disease. ..
  9. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2009
    ..The insights gained into basic processes of learning and memory will have fundamental implications for understanding memory disorders such as occur in amnesia and Alzheimer's disease. ..
  10. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003
    ....
  11. Protein Kinases in Synaptic Plasticity
    Roberto Malinow; Fiscal Year: 2007
    ..This will be examined early in development, when GluR4 controls synaptic delivery, and later in life, when synaptic delivery is controlled by GluR1...
  12. Regulation of GluR2 expression by synaptic activity
    Stephanie Gardner; Fiscal Year: 2004
    ..proteins (GRIP1/GRIP2 or PICK1) or that lack the last 7 amino acids of the C-terminus of GluR1, GluR2, GluR3, or GluR4. Next, the targets of Ca2+ influx through Ca2+- permeable AMPA receptors will be dissected with pharmacological ..
  13. Mapping AMPA-R trafficking in dendritic compartments
    Charles Kopec; Fiscal Year: 2006
    ..Working in young rat hippocampal slices we will first study the trafficking of GluR4, a process critical for early synaptic strengthening...
  14. Measurement of GPCR-mediated thallium flux:GIRK (RMI)
    COLLEEN NISWENDER; Fiscal Year: 2005
    ..Identified compounds will provide new pharmacological tools to test the role of the ?2C adrenergic receptor in psychiatric and cardiovascular disorders and the role of GIRK 1/2 channels in the modulation of neuronal excitability. ..
  15. METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIA
    COLLEEN NISWENDER; Fiscal Year: 2009
    ..Furthermore, we will test the hypothesis that agonists or allosteric potentiators of this receptor can provide palliative relief in rodent models of PD by actions in the GP. ..
  16. Olympus FV 1000 Confocal Microscope for Neurobiology and Cellular Biology Researc
    Francisco Alvarez; Fiscal Year: 2006
    ..As such, the acquisition of the Olympus FV 1000 systems will significantly enhance the research programs of the core investigators, but it will also have a beneficial impact on the broader research community at Wright State University. ..
  17. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  18. Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as Prot(RMI)
    COLLEEN NISWENDER; Fiscal Year: 2007
    ..abstract_text> ..
  19. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  20. Synapse-specific Regulation of Transmission and Integration in the Barrel Cortex
    J Julius Zhu; Fiscal Year: 2010
    ....
  21. Ocular Motor Adaptation in Health and Disease
    HOWARD SHANN CHERNG YING; Fiscal Year: 2010
    ....
  22. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2007
    ..Aim 1, we will complete our analysis of their impact on GluR3 and extend our analysis to include GluR2 and GluR4. Moreover, we will examine the effects of the four TARPs on heteromeric subunit combinations that are prevalent in ..
  23. RETINAL ORGANIZATION OF COLOR PATHWAYS
    DAVID CALKINS; Fiscal Year: 2002
    ....