GREB1

Summary

Gene Symbol: GREB1
Description: growth regulating estrogen receptor binding 1
Alias: protein GREB1, gene regulated by estrogen in breast cancer, gene regulated in breast cancer 1 protein, growth regulation by estrogen in breast cancer 1
Species: human
Products:     GREB1

Top Publications

  1. Rae J, Johnson M, Cordero K, Scheys J, Larios J, Gottardis M, et al. GREB1 is a novel androgen-regulated gene required for prostate cancer growth. Prostate. 2006;66:886-94 pubmed
    Gene regulated in breast cancer 1 (GREB1) is a novel estrogen-regulated gene shown to play a pivotal role in hormone-stimulated breast cancer growth...
  2. Deschênes J, Bourdeau V, White J, Mader S. Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences. J Biol Chem. 2007;282:17335-9 pubmed
    ..Here we show that the strong and sustained induction of the gene regulated in breast cancer 1 (GREB1), a gene of unknown function that has been previously suggested to play a role in the effects of estradiol on ..
  3. Hnatyszyn H, Liu M, Hilger A, Herbert L, Gomez Fernandez C, Jorda M, et al. Correlation of GREB1 mRNA with protein expression in breast cancer: validation of a novel GREB1 monoclonal antibody. Breast Cancer Res Treat. 2010;122:371-80 pubmed publisher
    Studies of gene regulated by estrogen in breast cancer 1 (GREB1) have focused on mRNA levels with limited evidence about GREB1 protein expression in normal and breast cancer cells...
  4. Ghosh M, Thompson D, Weigel R. PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res. 2000;60:6367-75 pubmed
    ..PDZK1 and a new gene, GREB1, demonstrated a significant correlation with ER phenotype in a panel of breast cancer cell lines...
  5. Mohammed H, D Santos C, Sérandour A, Ali H, Brown G, Atkins A, et al. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep. 2013;3:342-9 pubmed publisher
    ..The most estrogen-enriched ER interactor is GREB1, a potential clinical biomarker with no known function...
  6. Rae J, Johnson M, Scheys J, Cordero K, Larios J, Lippman M. GREB 1 is a critical regulator of hormone dependent breast cancer growth. Breast Cancer Res Treat. 2005;92:141-9 pubmed
    ..These data suggest that GREB 1 is critically involved in the estrogen induced growth of breast cancer cells and has the potential of being a clinical marker for response to endocrine therapy as well as a potential therapeutic target. ..
  7. Sun J, Nawaz Z, Slingerland J. Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. Mol Endocrinol. 2007;21:2651-62 pubmed
    ..GREB1 (gene regulated by estrogen in breast cancer 1) is an ER target gene that regulates estrogen-induced proliferation in breast cancer cells...
  8. Mortlock S, Restuadi R, Levien R, Girling J, Holdsworth Carson S, Healey M, et al. Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clin Epigenetics. 2019;11:49 pubmed publisher
    ..with reproductive traits and diseases, including one mQTL located in a known risk region for endometriosis (near GREB1)...
  9. Rafnar T, Gunnarsson B, Stefansson O, Sulem P, Ingason A, Frigge M, et al. Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits. Nat Commun. 2018;9:3636 pubmed publisher
    ..12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1)...

More Information

Publications53

  1. Camden A, Szwarc M, Chadchan S, DeMayo F, O Malley B, Lydon J, et al. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017;23:646-653 pubmed publisher
    Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial ..
  2. Haynes B, Viale G, Galimberti V, Rotmensz N, Gibelli B, Smith I, et al. Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat. 2014;148:327-35 pubmed publisher
    ..Expression of PGR, TFF1, GREB1 and PDZK1 followed the previously reported pattern: a higher level in W2 compared to W1 while W3 had an ..
  3. Hodgkinson K, Forrest L, Vuong N, Garson K, Djordjevic B, Vanderhyden B. GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer. Oncogene. 2018;37:5873-5886 pubmed publisher
    ..GREB1 (Growth regulation by estrogen in breast cancer 1) is an ESR1 (estrogen receptor 1)-upregulated protein which may mediate estrogen action...
  4. Rahmioglu N, Nyholt D, Morris A, Missmer S, Montgomery G, Zondervan K. Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Hum Reprod Update. 2014;20:702-16 pubmed publisher
    ..5 × 10(-8)), rs7739264 near ID4 (P = 6.2 × 10(-10)) and rs13394619 in GREB1 (P = 4.5 × 10(-8))...
  5. Haines C, Braunreiter K, Mo X, Burd C. GREB1 isoforms regulate proliferation independent of ERα co-regulator activities in breast cancer. Endocr Relat Cancer. 2018;25:735-746 pubmed publisher
    ..One gene target of ERα, growth regulation by estrogen in breast cancer 1 (GREB1), is associated with proliferation and regulation of ERα activity in estrogen-..
  6. Barrault C, Garnier J, Pedretti N, Cordier Dirikoc S, Ratineau E, Deguercy A, et al. Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor. J Steroid Biochem Mol Biol. 2015;152:34-44 pubmed publisher
    ..DHT) induced AR nuclear translocation and the strong modulation of a set of transcripts (RASD1, GREB1...) known to be androgen-sensitive in other androgenic cells and tissues...
  7. Panigrahi A, Foulds C, Lanz R, Hamilton R, Yi P, Lonard D, et al. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018;70:679-694.e7 pubmed publisher
    ..SRC-3 was identified as a critical looping determinant for the estradiol-(E2)-regulated GREB1 locus...
  8. Cheng M, Michalski S, Kommagani R. Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers. Int J Mol Sci. 2018;19: pubmed publisher
    ..Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1)...
  9. Osiński M, Mostowska A, Wirstlein P, Wender Ozegowska E, Jagodziński P, Szczepańska M. The assessment of GWAS - identified polymorphisms associated with infertility risk in Polish women with endometriosis. Ginekol Pol. 2018;89:304-310 pubmed publisher
    ..Caucasian population, which include rs12700667 near NFE2L3, rs12037376 in WNT4, rs7521902 near WNT4, rs13394619 in GREB1, rs10859871 near VEZT, rs1537377 near CDKN2B-AS1, rs4141819 near ETAA1, rs7739264 near ID4, rs1519761 near RND3 ..
  10. Veskimäe K, Scaravilli M, Niininen W, Karvonen H, Jaatinen S, Nykter M, et al. Expression Analysis of Platinum Sensitive and Resistant Epithelial Ovarian Cancer Patient Samples Reveals New Candidates for Targeted Therapies. Transl Oncol. 2018;11:1160-1170 pubmed publisher
    ..The data revealed new candidates for targeted therapies, such as GREB1 and ROR2...
  11. Ichii O, Nakamura T, Horino T, Yabuki A, Elewa Y, Kon Y. Abnormal Morphology of Distal Tubular Epithelial Cells Is Regulated by Genetic Factors Derived from Mouse Chromosome 12. Am J Pathol. 2018;188:2120-2138 pubmed publisher
    ..Within drecy, the gene regulated by estrogen in breast cancer protein (Greb1) transcript variant 2 was significantly up-regulated in DBA/2Cr kidney versus ..
  12. Dewi F, Wood C, Willson C, Register T, Lees C, Howard T, et al. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prev Res (Phila). 2016;9:385-95 pubmed publisher
    ..Expression of ERα and classical ERα response genes (TFF1, PGR, and GREB1) decreased with maturity, independent of diet...
  13. Hess J, Zendt J, Matala A, Narum S. Genetic basis of adult migration timing in anadromous steelhead discovered through multivariate association testing. Proc Biol Sci. 2016;283: pubmed publisher
    ..the annotated Salmo salar genome provided evidence that all three SNPs localize within a 46 kb region overlapping GREB1-like (an oestrogen target gene) on chromosome Ssa03...
  14. Lin J, Lei Z. Chromatin Immunoprecipitation with Estrogen Receptor 1 and the Promoter of Greb1 in TM4 Sertoli Cells. Methods Mol Biol. 2016;1366:67-77 pubmed publisher
    ..identified two canonical estrogen response elements (ERE1 and ERE2) present in the 5'-flanking region of the Greb1 gene which is a known estrogen-responsive gene...
  15. Monahan D, Wang J, Lee O, Revesz E, Taft N, Ivancic D, et al. Cytologic atypia in the contralateral unaffected breast is related to parity and estrogen-related genes. Surg Oncol. 2016;25:449-456 pubmed publisher
    ..005), including TFF1, AGT, PDZK1, PGR, GREB1, PRLR, CAMK2B, and CCND1...
  16. Li S, Liu W, Li Z, Li W, Wang Y, Zhou L, et al. greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 2017;627:176-187 pubmed publisher
    greb1, growth regulation by estrogen in breast cancer 1, is an important estrogen response gene, which participates in breast cancer formation. However, the role of greb1 in development is largely unknown...
  17. McDermott M, Chumanevich A, Lim C, Liang J, Chen M, Altilia S, et al. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017;8:12558-12575 pubmed publisher
    ..Estrogen addition stimulated the binding of CDK8 to the ER-responsive GREB1 gene promoter and CDK8/19 inhibition reduced estrogen-stimulated association of an elongation-competent ..
  18. Magne Nde C, Casas Gimeno G, Docanto M, Knower K, Young M, Buehn J, et al. Timeless Is a Novel Estrogen Receptor Co-activator Involved in Multiple Signaling Pathways in MCF-7 Cells. J Mol Biol. 2018;430:1531-1543 pubmed publisher
    ..Finally, Timeless is recruited with ERα on the GREB1 and cMyc promoters...
  19. Ribas R, Pancholi S, Guest S, Marangoni E, Gao Q, Thuleau A, et al. AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo. Mol Cancer Ther. 2015;14:2035-48 pubmed publisher
    ..in recruitment of ER and CREB-binding protein (CBP) to estrogen response elements located on the TFF1, PGR, and GREB1 promoters. Furthermore, AZD5363 reduced expression of cell-cycle-regulatory proteins...
  20. Nwachukwu J, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, et al. Predictive features of ligand-specific signaling through the estrogen receptor. Mol Syst Biol. 2016;12:864 pubmed publisher
    ..in a manner that was predicted by the canonical recruitment of the coactivators NCOA1/2/3 and induction of the GREB1 proliferative gene...
  21. Fritzsch C, Baumgartner S, Kuban M, Steinshorn D, Reid G, Legewie S. Estrogen-dependent control and cell-to-cell variability of transcriptional bursting. Mol Syst Biol. 2018;14:e7678 pubmed publisher
    ..To this end, single-cell dynamics of nascent transcripts were monitored at the endogenous estrogen-responsive GREB1 locus...
  22. Purcell D, Chauhan S, Jimenez Stinson D, Elliott K, Tsewang T, Lee Y, et al. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Mol Endocrinol. 2015;29:1708-19 pubmed publisher
    ..of DZIP3 by small interfering RNA in MCF7 cells reduced estradiol-induced gene expression of ERα target genes, GREB1 and pS2, and DZIP3 was recruited to the estrogen response elements of the same ERα target genes...
  23. Zhang W, Chen J, Aguilera Barrantes I, Shiau C, Sheng X, Wang L, et al. Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression. Mol Nutr Food Res. 2016;60:2387-2395 pubmed publisher
    ..UA enhanced the expression of ERβ, PGR, pS2, GREB1 while inhibiting the expression of ERα and GRIP1...
  24. Lin W, Huang J, Liao X, Yuan Z, Feng S, Xie Y, et al. Neo-tanshinlactone selectively inhibits the proliferation of estrogen receptor positive breast cancer cells through transcriptional down-regulation of estrogen receptor alpha. Pharmacol Res. 2016;111:849-858 pubmed publisher
    ..levels as well as the mRNA levels of target genes of this transcription factor, such as ESR2, BRCA1, CCND1, GREB1, TFF1, SERPINB9 and ABCA3...
  25. Simigdala N, Gao Q, Pancholi S, Roberg Larsen H, Zvelebil M, Ribas R, et al. Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer. Breast Cancer Res. 2016;18:58 pubmed publisher
    ..Additionally, recruitment of the ER and CREB-binding protein (CBP) to the TFF1 and GREB1 promoters was increased upon treatment with 25-HC and 27-HC...
  26. Bourdeau V, Deschênes J, Métivier R, Nagai Y, Nguyen D, Bretschneider N, et al. Genome-wide identification of high-affinity estrogen response elements in human and mouse. Mol Endocrinol. 2004;18:1411-27 pubmed
    ..Our results demonstrate that near-consensus EREs occur frequently in both genomes and that whereas chromatin structure likely modulates access to binding sites, far upstream elements can be evolutionarily conserved and bind ERs in vivo. ..
  27. Antunes A, Leite K, Reis S, Sousa Canavez J, Camara Lopes L, Dall oglio M, et al. GREB1 tissue expression is associated with organ-confined prostate cancer. Urol Oncol. 2012;30:16-20 pubmed publisher
    ..Among them, 3 genes, TMEFF2, GREB1, and TH1L, were at least 13-times overexpressed, and 1 gene, IGH3, which was at least 5 times under-expressed in ..
  28. Chand A, Wijayakumara D, Knower K, Herridge K, Howard T, Lazarus K, et al. The orphan nuclear receptor LRH-1 and ER? activate GREB1 expression to induce breast cancer cell proliferation. PLoS ONE. 2012;7:e31593 pubmed publisher
    ..We identified that LRH-1 regulated the expression of Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in MCF-7 and MDA-MB-231 cells...
  29. Nyholt D, Low S, Anderson C, Painter J, Uno S, Morris A, et al. Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet. 2012;44:1355-9 pubmed publisher
    ..12 near WNT4. In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871)...
  30. Fung J, Holdsworth Carson S, Sapkota Y, Zhao Z, Jones L, Girling J, et al. Functional evaluation of genetic variants associated with endometriosis near GREB1. Hum Reprod. 2015;30:1263-75 pubmed publisher
    Do DNA variants in the growth regulation by estrogen in breast cancer 1 (GREB1) region regulate endometrial GREB1 expression and increase the risk of developing endometriosis in women? We identified new single nucleotide polymorphisms (..
  31. Brunetti M, Panagopoulos I, Gorunova L, Davidson B, Heim S, Micci F. RNA-Sequencing identifies novel GREB1-NCOA2 fusion gene in a uterine sarcoma with the chromosomal translocation t(2;8)(p25;q13). Genes Chromosomes Cancer. 2017;: pubmed publisher
    ..We describe a novel fusion gene, GREB1-NCOA2, detected by transcriptome sequencing and validated by RT-PCR and Sanger sequencing in an undifferentiated ..
  32. De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, et al. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. Am J Hum Genet. 2017;101:803-814 pubmed publisher
    ..54 fetuses with BKA, led to the identification of 16 heterozygous variants in GREB1L (growth regulation by estrogen in breast cancer 1-like), a gene reported as a target of retinoic acid signaling...
  33. Hodgkinson K, Vanderhyden B. Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers. Expert Opin Ther Targets. 2014;18:1065-76 pubmed publisher
    ..evidence for the important role played by the steroid hormone-induced gene called GREB1, or growth regulation by estrogen in breast cancer 1. GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer ..
  34. Laviolette L, Hodgkinson K, Minhas N, Perez Iratxeta C, Vanderhyden B. 17β-estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo. Int J Cancer. 2014;135:1072-84 pubmed publisher
    ..The expression of gene regulated by estrogen in breast cancer 1 (Greb1) was upregulated in mouse tumors treated with E2 and was overexpressed in human ..
  35. Bauerschlag D, Ammerpohl O, Bräutigam K, Schem C, Lin Q, Weigel M, et al. Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. Oncology. 2011;80:12-20 pubmed publisher
    ..Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C)...
  36. Rittie L, Kang S, Voorhees J, Fisher G. Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo. Arch Dermatol. 2008;144:1129-40 pubmed publisher
    ..Estradiol treatment induced the estrogen-responsive gene GREB1, indicating that penetration of topical estradiol and genomic response to estrogen were similar in the 3 anatomic ..
  37. Hegarty K, Drummond F, Daly M, Shanahan F, Molloy M. GREB1 genetic variants are associated with bone mineral density in Caucasians. J Bone Miner Metab. 2018;36:189-199 pubmed publisher
    ..The growth regulation by oestrogen in breast cancer 1 (GREB1) gene, with an as yet undefined function, is an early response gene in the oestrogen-regulated pathway...
  38. Wu Y, Zhang Z, Cenciarini M, Proietti C, Amasino M, Hong T, et al. Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 2018;78:671-684 pubmed publisher
    ..EZH2 conferred tamoxifen resistance by silencing the expression of the estrogen receptor α (ERα) cofactor GREB1. In clinical specimens, induction of DNA methylation of a particular CpG-enriched region at the GREB1 ..
  39. Sapkota Y, Vivo I, Steinthorsdottir V, Fassbender A, Bowdler L, Buring J, et al. Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry. Sci Rep. 2017;7:11380 pubmed publisher
    ..3 × 10-9) in GREB1 at 2p25.1 - a locus previously identified in a GWA meta-analysis of European and Japanese samples...
  40. Brophy P, Rasmussen M, Parida M, Bonde G, Darbro B, Hong X, et al. A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. Genetics. 2017;207:215-228 pubmed publisher
    ..GREB1L resides in a chromatin complex with RAR members, and our data implicate GREB1L as a coactivator for RARs. This study is the first to associate a component of the RAR pathway with renal agenesis in humans. ..
  41. Wang Z, Li T, Xing X, Gao X, Zhang X, You L, et al. Replication study of RAD54B and GREB1 polymorphisms and risk of PCOS in Han Chinese. Reprod Biomed Online. 2013;27:316-21 pubmed publisher
    ..present study, an independent cohort was used for a replication study to evaluate the association of RAD54B and GREB1 with polycystic ovary syndrome (PCOS) in the Han Chinese population...
  42. Sanna Cherchi S, Khan K, Westland R, Krithivasan P, Fievet L, Rasouly H, et al. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Am J Hum Genet. 2017;101:789-802 pubmed publisher
    ..Together, our study provides insight into the genetic landscape of kidney malformations in humans, presents multiple candidates, and identifies SLIT3 and GREB1L as genes implicated in the pathogenesis of RHD. ..
  43. Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, et al. The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis. Fertil Steril. 2012;98:1200-8 pubmed publisher
    ..of estrogen receptors ? and ? as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis. Expression analysis in human tissue...
  44. Haynes B, Ginsburg O, Gao Q, Folkerd E, Afentakis M, Quang L, et al. Molecular changes in premenopausal oestrogen receptor-positive primary breast cancer in Vietnamese women after oophorectomy. NPJ Breast Cancer. 2017;3:47 pubmed publisher
    ..25 (257 up, 398 down). Archetypal oestrogen-regulated genes (TFF1, GREB1, PGR and PDZK1) showed large decreases in expression (FC?=?0.20-0.69; p?<?1e-6-1e-7)...