GRB14

Summary

Gene Symbol: GRB14
Description: growth factor receptor bound protein 14
Alias: growth factor receptor-bound protein 14, GRB14 adapter protein
Species: human
Products:     GRB14

Top Publications

  1. Daly R, Sanderson G, Janes P, Sutherland R. Cloning and characterization of GRB14, a novel member of the GRB7 gene family. J Biol Chem. 1996;271:12502-10 pubmed
    ..C terminus of the epidermal growth factor receptor identified a novel member of the GRB7 gene family, designated GRB14. In addition to a pleckstrin homology domain-containing central region homologous to the Caenorhabditis elegans ..
  2. Nouaille S, Blanquart C, Zilberfarb V, Boute N, Perdereau D, Roix J, et al. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO Rep. 2006;7:512-8 pubmed
    The dynamics of interaction of the insulin receptor (IR) with Grb14 was monitored, in real time, in living human embryonic kidney cells, using bioluminescence resonance energy transfer (BRET)...
  3. Depetris R, Hu J, Gimpelevich I, Holt L, Daly R, Hubbard S. Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell. 2005;20:325-33 pubmed
    b>Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2) domain, and an intervening stretch of approximately 45 residues known as the BPS region, which is unique ..
  4. Heid I, Jackson A, Randall J, Winkler T, Qi L, Steinthorsdottir V, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949-60 pubmed publisher
    ..We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1...
  5. Bereziat V, Kasus Jacobi A, Perdereau D, Cariou B, Girard J, Burnol A. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. J Biol Chem. 2002;277:4845-52 pubmed
    b>Grb14 belongs to the Grb7 family of adapters and was recently identified as a partner of the insulin receptor (IR). Here we show that Grb14 inhibits in vitro IR substrate phosphorylation...
  6. Han D, Shen T, Guan J. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 2001;20:6315-21 pubmed
    Grb7 family adaptor molecules consist of Grb7, Grb10 and Grb14, each of which has several splicing variants...
  7. Reilly J, Mickey G, Maher P. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J Biol Chem. 2000;275:7771-8 pubmed
    Using the cytoplasmic domain of fibroblast growth factor receptor 1 (FGFR1) as bait in a yeast two-hybrid screen, Grb14 was identified as a FGFR1 binding partner...
  8. Kasus Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais Jarvis F, et al. Identification of the rat adapter Grb14 as an inhibitor of insulin actions. J Biol Chem. 1998;273:26026-35 pubmed
    We cloned by interaction with the beta-subunit of the insulin receptor the rat variant of the human adapter Grb14 (rGrb14). rGrb14 is specifically expressed in rat insulin-sensitive tissues and in the brain...
  9. Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys Poly E, Perdereau D, et al. Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol. 2009;23:1043-51 pubmed publisher
    b>Grb14 belongs to the Grb7 family of molecular adapters and was identified as an inhibitor of insulin signaling. Grb14 binds to activated insulin receptors (IR) and inhibits their catalytic activity...

More Information

Publications62

  1. Ji Y, Yiorkas A, Frau F, Mook Kanamori D, Staiger H, Thomas E, et al. Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes. 2019;68:207-219 pubmed publisher
    ..with higher body fat % but lower liver fat and lower risk of type 2 diabetes included those in PPARG, GRB14, and IRS1, whereas the allele in ANKRD55 was paradoxically associated with higher visceral fat ..
  2. Ezzat S, Zheng L, Florez J, Stefan N, Mayr T, Hliang M, et al. The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. Cell Metab. 2013;17:929-40 pubmed publisher
    ..This STAT activation transcriptionally induces Grb14 in pancreatic endocrine cells to promote insulin secretion...
  3. Nickel K, Tebartz van Elst L, Domschke K, Gläser B, Stock F, Endres D, et al. Heterozygous deletion of SCN2A and SCN3A in a patient with autism spectrum disorder and Tourette syndrome: a case report. BMC Psychiatry. 2018;18:248 pubmed publisher
    ..3 leading to a deletion encompassing the five genes SCN2A (exon 1 to intron 14-15), SCN3A, GRB14 (exon 1 to intron 2-3), COBLL1 and SCL38A11...
  4. Ishikawa A, Okuno S. Fine mapping and candidate gene search of quantitative trait loci for growth and obesity using mouse intersubspecific subcongenic intercrosses and exome sequencing. PLoS ONE. 2014;9:e113233 pubmed publisher
    ..5. Exome sequencing and candidate gene prioritization suggested that Gcg and Grb14 are putative candidate genes for Pbwg1.12 and that Ly75 and Itgb6 are putative candidate genes for Pbwg1.5...
  5. Arora G, Almgren P, Brøns C, Thaman R, Vaag A, Groop L, et al. Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women. BMC Med Genomics. 2018;11:64 pubmed publisher
    ..In support of previous findings in Caucasian GDM, SNPs at KCJN11 and GRB14 loci were nominally associated with GDM1999 risk in Indian women (both p = 0.02)...
  6. Shabana -, Shahid S, Hasnain S. Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs. Lipids Health Dis. 2018;17:155 pubmed publisher
    ..protein 2 (FABP2) gene, rs1121980 in fat mass and obesity associated (FTO) gene, rs3923113 in Growth Factor Receptor Bound Protein 14 (GRB14), rs16861329 in Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1), rs1802295 in ..
  7. Jia Z, Ai X, Sun F, Zang T, Guan Y, Gao F. Identification of new hub genes associated with bladder carcinoma via bioinformatics analysis. Tumori. 2015;101:117-22 pubmed publisher
    ..ITGA7 (integrin, alpha 7), GRB14 (growth factor receptor-bound protein 14), CDC20 (cell division cycle 20) and PSMB1 (proteasome subunit, beta type,..
  8. Nettleton J, Follis J, Ngwa J, Smith C, Ahmad S, Tanaka T, et al. Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24:4728-38 pubmed publisher
    ..006-0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-..
  9. Rahmioglu N, Macgregor S, Drong A, Hedman Ã, Harris H, Randall J, et al. Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Hum Mol Genet. 2015;24:1185-99 pubmed publisher
    ..significant evidence of involvement in both endometriosis and WHRadjBMI (in/near KIFAP3, CAB39L, WNT4, GRB14); two of these, KIFAP3 and CAB39L, are novel associations for both traits. KIFAP3, WNT4 and 7p15...
  10. Kraja A, Chasman D, North K, Reiner A, Yanek L, Kilpeläinen T, et al. Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab. 2014;112:317-38 pubmed publisher
    ..They map to genes MACF1, KIAA0754, GCKR, GRB14, COBLL1, LOC646736-IRS1, SLC39A8, NELFE, SKIV2L, STK19, TFAP2B, BAZ1B, BCL7B, TBL2, MLXIPL, LPL, TRIB1, ATXN2, ..
  11. Hessel E, van Lith H, Wolterink Donselaar I, de Wit M, Groot Koerkamp M, Holstege F, et al. Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a. Eur J Neurosci. 2016;44:2950-2957 pubmed publisher
    ..Cytip, Fmnl2 Ifih1) contained a non-synonymous SNP comparing CSS2 and C57BL/6J, six genes (March7, Nr4a2, Gpd2, Grb14, Scn1a, Scn3a) were differentially expressed between these strains...
  12. Gunzburg M, Kulkarni K, Watson G, Ambaye N, Del Borgo M, Brandt R, et al. Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep. 2016;6:27060 pubmed publisher
    ..83 μM) compared to G7-B1 and shows low affinity binding to Grb2-, Grb10- and Grb14-SH2 domains (KD > 100 μM)...
  13. Kanthimathi S, Chidambaram M, Bodhini D, Liju S, Bhavatharini A, Uma R, et al. Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population. Mol Genet Genomics. 2017;292:585-591 pubmed publisher
    ..A total of nine SNPs in or near nine loci, namely AP3S2 (rs2028299), BAZ1B (rs12056034), CDKN2A/B (rs7020996), GRB14 (rs3923113), HHEX (rs7923837), HMG20A (rs7178572), HNF4A (rs4812829), ST6GAL1 (rs16861329) and VPS26A (rs1802295) ..
  14. Popineau L, Morzyglod L, Carré N, Caüzac M, Bossard P, Prip Buus C, et al. Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance. Mol Cell Biol. 2016;36:2168-81 pubmed publisher
    ..by silencing an inhibitor of insulin receptor catalytic activity, the growth factor receptor binding protein 14 (Grb14) in liver...
  15. Seroussi E, Rosov A, Shirak A, Lam A, Gootwine E. Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed. Genet Sel Evol. 2017;49:19 pubmed publisher
    ..Genes associated with fat distribution in humans, including GRB14 and COBLL1, were located in additional VGR...
  16. Yang H, Liang Y, Chen J, Chiang K, Chung C, Ho H, et al. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS ONE. 2012;7:e32907 pubmed publisher
    ..SFMBT1, which encodes the scm-like with four MBT domains protein 1, is a novel hypertension gene. GRB14, TMEM56 and KIAA1797 exhibited highly significant differential allelic and expressed distributions between ..
  17. Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, et al. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Transl Psychiatry. 2014;4:e396 pubmed publisher
    ..We identified eight genes, RELN, PTGS2, MYO5C, TRIL, DCHS2, GRB14, NPAS4 and PHYHD1, associated with the Braak stage...
  18. Gondoin A, Hampe C, Eudes R, Fayolle C, Pierre Eugène C, Miteva M, et al. Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14. Sci Rep. 2017;7:16901 pubmed publisher
    ..Growth factor receptor-bound protein 14 (Grb14) is a molecular adapter that specifically binds to the activated insulin receptor (IR) and inhibits its tyrosine ..
  19. Lyons R, Deane R, Lynch D, Ye Z, Sanderson G, Eyre H, et al. Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14. J Biol Chem. 2001;276:17172-80 pubmed
    ..in a yeast two-hybrid screen as a binding partner for the Src homology 2 domain-containing adaptor protein Grb14. Tankyrase 2 is a 130-kDa protein, which lacks the N-terminal histidine/proline/serine-rich region of tankyrase, ..
  20. Hemming R, Agatep R, Badiani K, Wyant K, Arthur G, Gietz R, et al. Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins. Biochem Cell Biol. 2001;79:21-32 pubmed
    ..The broad effects of hGrb14 overexpression on insulin-stimulated tyrosine phosphorylation suggest that it acts early in the insulin-signaling pathway. ..
  21. Taira J, Higashimoto Y. Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor. J Biochem. 2014;155:353-60 pubmed publisher
    Growth factor receptor-bound protein 14 (Grb14) interacts with insulin receptor (IR) through the between PH and SH2 (BPS) domain...
  22. Chen J, Meng Y, Zhou J, Zhuo M, Ling F, Zhang Y, et al. Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells. J Diabetes Res. 2013;2013:970435 pubmed publisher
    ..were identified from the T2DM-control study, and BCAT1, BMP2K, CSRNP2, MYNN, NCKAP5L, SAP30BP, SLC35B4, SP1, BAP1, GRB14, HSP90AB1, ITGA5, and TOMM5 were identified from the obesity-control study...
  23. Shabana -, Ullah Shahid S, Wah Li K, Acharya J, Cooper J, Hasnain S, et al. Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects. Eur J Hum Genet. 2016;24:903-10 pubmed publisher
    The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (..
  24. Qian L, Bradford A, Cooke P, Lyons B. Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1. J Mol Recognit. 2016;29:318-33 pubmed publisher
    ..Grb7, with Grb10 and Grb14, is members of the Grb7 protein family...
  25. Baker E, Sutherland G, Sutherland R, Daly R. Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization. Genomics. 1996;36:218-20 pubmed
  26. Martino B, Mammì C, Labate C, Rodi S, Ielo D, Priolo M, et al. Genetic risk of prediabetes and diabetes development in chronic myeloid leukemia patients treated with nilotinib. Exp Hematol. 2017;55:71-75 pubmed publisher
    ..We evaluated uGRS predictivity in 61 CML patients treated with nilotinib. Patients were genotyped for IRS1, GRB14, ARL15, PPARG, PEPD, ANKRD55/MAP3K1, PDGFC, LYPLAL1, RSPO3, and FAM13A1 genes...
  27. van Vliet Ostaptchouk J, den Hoed M, Luan J, Zhao J, Ong K, van der Most P, et al. Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia. 2013;56:2134-46 pubmed publisher
    ..The WHR-increasing alleles at two WHR loci were significantly associated with higher proinsulin (GRB14: 0.069 SD) and lower fasting glucose levels (CPEB4: -0.049 SD), independent of BMI and WHR...
  28. Woodruff M, Rajala A, Fain G, Rajala R. Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014;289:358-64 pubmed publisher
    Previous experiments have indicated that growth factor receptor-bound protein 14 (Grb14) may modulate rod photoreceptor cGMP-gated channels by decreasing channel affinity for cGMP; however, the function of Grb14 in rod physiology is not ..
  29. King C, Newton A. The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2004;279:37518-27 pubmed
    ..We used a directed proteomics-based approach to identify the adaptor protein Grb14, which binds the insulin receptor through an SH2 domain, as a novel PDK-1 binding partner...
  30. Vink J, Smit A, de Geus E, Sullivan P, Willemsen G, Hottenga J, et al. Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet. 2009;84:367-79 pubmed publisher
    ..g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23)...
  31. Kopp K, Buntru A, Pils S, Zimmermann T, Frank R, Zumbusch A, et al. Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria. J Biol Chem. 2012;287:39158-70 pubmed publisher
    ..screen using a SH2 domain microarray we identified the SH2 domain of growth factor receptor-bound protein 14 (Grb14) as a novel binding partner of CEACAM3...
  32. Depetris R, Wu J, Hubbard S. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nat Struct Mol Biol. 2009;16:833-9 pubmed publisher
    Growth factor receptor-binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal Src-..
  33. Dong L, Du H, Porter S, Kolakowski L, Lee A, Mandarino L, et al. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. J Biol Chem. 1997;272:29104-12 pubmed
    ..We have also determined the human chromosome localization of Grb7 to 17q21-q22 and Grb14 to chromosome 2...
  34. Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, et al. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999;274:30896-905 pubmed
    ..Using this approach, we demonstrate that five molecules, Grb2, Grb7, Grb14, Shp2, and the p85 subunit of phosphatidylinositol 3-kinase can interact with Tek in a phosphotyrosine-dependent ..
  35. Scharf P, Witney J, Daly R, Lyons B. Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain. Protein Sci. 2004;13:2541-6 pubmed
    b>Grb14 is an adapter protein that is known to be overexpressed in estrogen receptor positive breast cancers, and in a number of prostate cancer cell lines...
  36. Park J, Berggren J, Hulver M, Houmard J, Hoffman E. GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Physiol Genomics. 2006;27:114-21 pubmed
    ..morbidly obese (n = 8) muscle. Growth factor receptor-bound protein 14 (GRB14), glycerol-3-phosphate dehydrogenase 1 (GPD1), and growth differentiation factor 8 (GDF8; myostatin) significantly ..
  37. Browaeys Poly E, Blanquart C, Perdereau D, Antoine A, Goenaga D, Luzy J, et al. Grb14 inhibits FGF receptor signaling through the regulation of PLC? recruitment and activation. FEBS Lett. 2010;584:4383-8 pubmed publisher
    To decipher the mechanism involved in Grb14 binding to the activated fibroblast growth factor receptor (FGFR), we used the bioluminescence resonance energy transfer (BRET) technique and the Xenopus oocyte model...
  38. Kooner J, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43:984-9 pubmed publisher
    ..In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1...
  39. Perdereau D, Cailliau K, Browaeys Poly E, Lescuyer A, Carré N, Benhamed F, et al. Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner. Cell Signal. 2015;27:798-806 pubmed publisher
    ..Chfr is identified as a partner of the molecular adapter Grb14, an inhibitor of insulin signalling...
  40. Harder M, Ribel Madsen R, Justesen J, Sparsø T, Andersson E, Grarup N, et al. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J Clin Endocrinol Metab. 2013;98:E801-6 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry...
  41. Randall J, Winkler T, Kutalik Z, Berndt S, Jackson A, Monda K, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013;9:e1003500 pubmed publisher
    ..Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), ..
  42. Kato N, Takeuchi F, Tabara Y, Kelly T, Go M, Sim X, et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011;43:531-8 pubmed publisher
    ..P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3...
  43. Yang P, Wei J, Li W, He F, Zeng S, Zhang T, et al. High expression of growth factor receptor-bound protein 14 predicts poor prognosis for colorectal cancer patients. Biotechnol Lett. 2016;38:1043-7 pubmed publisher
    To explore the roles of growth factor receptor-bound protein 14 (GRB14) in colorectal cancer (CRC) and its correlation with clinicopathological characteristics and prognosis of CRC patients...
  44. Balogh K, Asa S, Zheng L, Cassol C, Cheng S, Ezzat S. The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression. Oncogene. 2012;31:4012-21 pubmed publisher
    ..b>Grb14 inhibits insulin receptor (IR) catalytic activity through interaction with the BPS domain and impedes peptide ..
  45. Eze I, Imboden M, Kumar A, von Eckardstein A, Stolz D, Gerbase M, et al. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Environ Int. 2016;94:263-271 pubmed publisher
    ..We observed similar results with weighted-GRS. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05)...
  46. Lu S, Xie Y, Lin K, Li S, Zhou Y, Ma P, et al. Genome-wide association studies-derived susceptibility loci in type 2 diabetes: confirmation in a Chinese population. Clin Invest Med. 2012;35:E327 pubmed
    ..Five single nucleotide polymorphisms (SNPs) were genotyped: rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, and rs231362 near KCNQ1, by high-resolution ..
  47. Taira J, Kida Y, Inatomi K, Komatsu H, Higashimoto Y, Sakamoto H. Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor. J Biochem. 2017;162:113-122 pubmed publisher
    Growth factor receptor-bound protein 14 (Grb14) is a negative regulator of insulin receptor (IR) and is involved in a negative feedback mechanism of insulin signaling...
  48. Kairouz R, Parmar J, Lyons R, Swarbrick A, Musgrove E, Daly R. Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells. J Cell Physiol. 2005;203:85-93 pubmed
    ..In this study, a positive correlation between Grb14 protein expression and ER alpha status in breast cancer cell lines led us to investigate regulation of Grb14 by ..
  49. García Palmero I, Pompas Veganzones N, Villalobo E, Gioria S, Haiech J, Villalobo A. The adaptors Grb10 and Grb14 are calmodulin-binding proteins. FEBS Lett. 2017;591:1176-1186 pubmed publisher
    We identified the Grb7 family members, Grb10 and Grb14, as Ca2+ -dependent CaM-binding proteins using Ca2+ -dependent CaM-affinity chromatography as we previously did with Grb7...
  50. Desbuquois B, Carré N, Burnol A. Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins. FEBS J. 2013;280:794-816 pubmed publisher
    ..Consistent with Grb14 binding as a pseudosubstrate to the kinase active site, insulin/IGF-induced activation of receptors and downstream ..
  51. Chen D, Xu L, Chen L, Li L, Zhai Z, Shu H. NIK is a component of the EGF/heregulin receptor signaling complexes. Oncogene. 2003;22:4348-55 pubmed
    ..Coimmunoprecipitation experiments demonstrated that NIK interacted with Grb7, as well as Grb10 and Grb14, but not Grb2...
  52. Schleinitz D, Klöting N, Lindgren C, Breitfeld J, Dietrich A, Schön M, et al. Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio. Int J Obes (Lond). 2014;38:120-5 pubmed publisher
    ..Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3 and GRB14) within these loci showing coincident cis-expression quantitative trait loci was measured in 222 paired samples of ..
  53. Cariou B, Perdereau D, Cailliau K, Browaeys Poly E, Bereziat V, Vasseur Cognet M, et al. The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. Mol Cell Biol. 2002;22:6959-70 pubmed
    b>Grb14 is a member of the Grb7 family of adapters and acts as a negative regulator of insulin-mediated signaling. Here we found that the protein kinase Czeta (PKCzeta) interacting protein, ZIP, interacted with Grb14...