GRB10

Summary

Gene Symbol: GRB10
Description: growth factor receptor bound protein 10
Alias: GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor-bound protein 10, GRB10 adapter protein, GRB10 adaptor protein, insulin receptor-binding protein Grb-IR, maternally expressed gene 1
Species: human
Products:     GRB10

Top Publications

  1. Nantel A, Mohammad Ali K, Sherk J, Posner B, Thomas D. Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases. J Biol Chem. 1998;273:10475-84 pubmed
    b>Grb10 and its close homologues Grb7 and Grb14, belong to a family of adapter proteins characterized by a proline-rich region, a central PH domain, and a carboxyl-terminal Src homology 2 (SH2) domain...
  2. Blagitko N, Mergenthaler S, Schulz U, Wollmann H, Craigen W, Eggermann T, et al. Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion. Hum Mol Genet. 2000;9:1587-95 pubmed
    As part of a systematic screen for novel imprinted genes of human chromosome 7 we have investigated GRB10, which belongs to a small family of adapter proteins, known to interact with a number of receptor tyrosine kinases and signalling ..
  3. Stein E, Ghirlando R, Hubbard S. Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity. J Biol Chem. 2003;278:13257-64 pubmed
    Grb7, Grb10, and Grb14 are members of a distinct family of adapter proteins that interact with various receptor tyrosine kinases upon receptor activation...
  4. Rampersaud E, Damcott C, Fu M, Shen H, McArdle P, Shi X, et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes. 2007;56:3053-62 pubmed
    ..07 x 10(-5)) was for rs2237457, which is located in growth factor receptor-bound protein 10 (Grb10), an adaptor protein that regulate insulin receptor signaling...
  5. Monk D, Arnaud P, Frost J, Hills F, Stanier P, Feil R, et al. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Hum Mol Genet. 2009;18:3066-74 pubmed publisher
    ..Genomic imprinting may have evolved not only to regulate fetal growth and development, but also behaviour. The mouse Grb10 gene provides a remarkable model to explore this idea because it shows paternal expression in brain, whereas in ..
  6. Litzky J, Deyssenroth M, Everson T, Armstrong D, Lambertini L, Chen J, et al. Placental imprinting variation associated with assisted reproductive technologies and subfertility. Epigenetics. 2017;12:653-661 pubmed publisher
    ..Three of the 45 genes significantly dysregulated between subfertile and control placentae-GRB10, NDN, and CD44 -were found to have a significant positive correlation between expression and birth weight...
  7. Adnani L, Langevin L, Gautier E, Dixit R, Parsons K, Li S, et al. Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1. J Neurosci. 2015;35:13430-47 pubmed publisher
    ..g., Dlk1, Peg3, Ube3a, necdin, and Grb10). Herein we show that the maternally imprinted gene Zac1 is a critical regulator of neocortical development...
  8. Sferruzzi Perri A, Vaughan O, Haro M, Cooper W, Musial B, Charalambous M, et al. An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory. FASEB J. 2013;27:3928-37 pubmed publisher
    ..3-kinase and mitogen-activated protein kinase), and several growth regulatory imprinted genes (Igf2, Dlk1, Snrpn, Grb10, and H19) independently of changes in DNA methylation...
  9. Shen W, Yau B, Lee S, Zhu L, Yam M, Gillies M. Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions. Int J Mol Sci. 2017;18: pubmed publisher
    ..The production of neurotrophic factors in Müller cells and interphotoreceptor retinoid-binding protein (IRBP) in photoreceptors was measured by enzymelinked immunosorbent assays...

More Information

Publications121 found, 100 shown here

  1. Barrow T, Barault L, Ellsworth R, Harris H, Binder A, Valente A, et al. Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer. Int J Cancer. 2015;137:537-47 pubmed publisher
    ..methylation changes at IGF2 DMR2 were observed in 59% of cancer patients, IGF2 DMR0 in 38%, DIRAS3 DMR in 36%, GRB10 ICR in 23%, PEG3 DMR in 21%, MEST ICR in 19%, H19 ICR in 18%, KvDMR in 8% and SNRPN/SNURF ICR in 4%...
  2. Moore G, Ishida M, Demetriou C, Al Olabi L, Leon L, Thomas A, et al. The role and interaction of imprinted genes in human fetal growth. Philos Trans R Soc Lond B Biol Sci. 2015;370:20140074 pubmed publisher
    ..Expression of the growth factor receptor-bound protein 10 (GRB10) in term placenta is significantly negatively correlated with head circumference...
  3. Yang M, Hall J, Fan Z, Regouski M, Meng Q, Rutigliano H, et al. Oocytes from small and large follicles exhibit similar development competence following goat cloning despite their differences in meiotic and cytoplasmic maturation. Theriogenology. 2016;86:2302-2311 pubmed publisher
    ..analysis of 48 genes associated with embryonic and fetal development revealed that three genes (MATER, IGF2R, and GRB10) had higher level of expression in metaphase II oocytes from large follicles compared with oocytes from small ..
  4. Ahmed C, Massengill M, Brown E, ILDEFONSO C, Johnson H, Lewin A. A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis. Exp Eye Res. 2018;177:12-22 pubmed publisher
    ..RIII mice using a peptide of interphotoreceptor retinal binding protein (IRBP161-180) as immunogen...
  5. Yamazaki W, Takahashi M, Kawahara M. Restricted development of mouse triploid fetuses with disorganized expression of imprinted genes. Zygote. 2015;23:874-84 pubmed publisher
    ..genes, Igf2, Dlk1, Ndn, and Peg3, remained significantly reduced and that of maternally expressed genes, Igf2r and Grb10, increased...
  6. Nie K, Wang K, Huang D, Huang Y, Yin W, Ren D, et al. Effects of circadian clock protein Per1b on zebrafish visual functions. Chronobiol Int. 2018;35:160-168 pubmed publisher
    ..per1, period1; per2, period2; per3, period3; ERG, electroretinogram; DA-IPCs, dopaminergic interplexiform cells; IRBP, interphotoreceptor retinoid binding protein; MS-222, methane-sulfonate; USTC, University of Science and Technology ..
  7. Beltran W, Cideciyan A, Boye S, Ye G, Iwabe S, Dufour V, et al. Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations. Mol Ther. 2017;25:1866-1880 pubmed publisher
    ..clinical trial, we have here optimized the therapeutic AAV vector construct by showing that GRK1 (rather than IRBP) is a more efficient promoter for targeting gene expression to both rods and cones in non-human primates...
  8. Yang F, Ma H, Boye S, Hauswirth W, Ding X. Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice. Adv Exp Med Biol. 2018;1074:125-131 pubmed publisher
    ..Subretinal delivery of AAV5-IRBP/GNAT2-hDIO3 induced robust expression of DIO3 in the mouse retina and significantly reduced the number of TUNEL-..
  9. Congras A, Yerle Bouissou M, Pinton A, Vignoles F, Liaubet L, Ferchaud S, et al. Sperm DNA methylation analysis in swine reveals conserved and species-specific methylation patterns and highlights an altered methylation at the GNAS locus in infertile boars. Biol Reprod. 2014;91:137 pubmed publisher
    ..the imprinting status of five of them not previously described in swine tissues: WT1, CNTN3, IMPACT, QPCT, and GRB10. DNA methylation level was then quantified in fertile and infertile boars at these 42 loci...
  10. Stevens A, Murray P, Wojcik J, Raelson J, Koledova E, Chatelain P, et al. Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study. Eur J Endocrinol. 2016;175:633-643 pubmed
    ..gt;4 to <10 ?g/L on GH stimulation test), however, in severe GHD (?4 ?g/L) several SNPs contributed (in IGF2, GRB10, FOS, IGFBP3 and GHRHR)...
  11. Aravindan S, Ramraj S, Kandasamy K, Thirugnanasambandan S, Somasundaram D, Herman T, et al. Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells. Oncotarget. 2017;8:5717-5734 pubmed publisher
    ..resulted in translational repression of IR-induced CXCR4, COX2, β-catenin, MMP9, Ki-67, BAPX, PhPT-1, MEGF10, and GRB10 in residual PC...
  12. Hyndman B, Crupi M, Peng S, Bone L, Rekab A, Lian E, et al. Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization. J Cell Sci. 2017;130:3282-3296 pubmed publisher
    ..of key RET9 C-terminal binding motifs that facilitate interactions with multiple adaptor proteins, including GRB10 and SHANK2, to recruit the NEDD4 ubiquitin ligase...
  13. Gibson C, de Ruijter Villani M, Stout T. Negative uterine asynchrony retards early equine conceptus development and upregulation of placental imprinted genes. Placenta. 2017;57:175-182 pubmed publisher
    ..Maternal (GRB10, H19, IGF2R, PHLDA2) and paternal (IGF2, INSR, PEG3, PEG10, DIO3, NDN, SNRPN) imprinted genes and DNMTs (DNMT1, 3A ..
  14. Zhang T, Ma Y, Fang J, Liu C, Chen L. A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. J Gastrointest Cancer. 2019;50:35-41 pubmed publisher
    ..signaling pathway in CRC tumoral tissue, among which 12 genes, CCND1, CSNK2A1, EIF4E, EIF4EBP1, EIF4G1, FOS, GRB10, GSK3B, ILK, PTK2, PTPN11, and PHEB were significantly up-modulated (> two fold) while the remaining two, PDK1 ..
  15. Laguna Barraza R, Sánchez Calabuig M, Gutierrez Adan A, Rizos D, Pérez Cerezales S. Effects of the HDAC inhibitor scriptaid on the in vitro development of bovine embryos and on imprinting gene expression levels. Theriogenology. 2018;110:79-85 pubmed publisher
    ..Further, genes involved in the mechanism of paternal imprinting (GRB10, GNAS, XIST) were downregulated in presence of SCR compared with controls...
  16. Sun D, Sahu B, Gao S, Schur R, Vaidya A, Maeda A, et al. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017;7:42-52 pubmed publisher
    ..All-trans-retinylamine, which binds to interphotoreceptor retinoid-binding protein (IRBP), was incorporated into the nanoparticles via a polyethylene glycol (PEG) spacer for targeted delivery of pDNA ..
  17. Doroszko M, Chruściel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, et al. Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice. Mol Cell Endocrinol. 2017;444:9-18 pubmed publisher
    ..Besides earlier reported Gata4 and Lhcgr, we found up-regulated Esr1, Prlr-rs1, and down-regulated Grb10, Mmp24, Sgcd, Rerg, Gnas, Nfatc2, Gnrhr, Igf2 in inh?/Tag adrenal tumors...
  18. Sluch V, Banks A, Li H, Crowley M, Davis V, Xiang C, et al. ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse. Sci Rep. 2018;8:14339 pubmed publisher
    ..Moreover, we found elevated levels of IRBP in both the AdipoR1 KO and the Mfrprd6 models. The spatial distribution of IRBP was also abnormal...
  19. Clayton P, Chatelain P, Tato L, Yoo H, Ambler G, Belgorosky A, et al. A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome. Eur J Endocrinol. 2013;169:277-89 pubmed publisher
    ..For example, in GHD, GRB10 was associated with high response (≥ Q3; P=0.0012), while SOS2 was associated with low response (≤ Q1; P=0...
  20. Li W, Zhou L, Li Z, Wang Y, Shi J, Yang Y, et al. Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. Int J Biol Sci. 2015;11:688-700 pubmed publisher
    ..specifically inhibits expression of multiple photoreceptor-specific genes, such as opsins, gnat1, gnat2 and irbp. Interestingly, otx2 expression in the morphants is not significantly reduced until 32 hpf when lbh-like begins to ..
  21. Bai L, Shao H, Wang H, Zhang Z, Su C, Dong L, et al. Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. Sci Rep. 2017;7:4323 pubmed publisher
    ..However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed...
  22. Lamba D, McUsic A, Hirata R, Wang P, Russell D, Reh T. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE. 2010;5:e8763 pubmed publisher
    ..fluorescence activated cell sorting (FACS) after labeling photoreceptors with a lentivirus driving GFP from the IRBP cis-regulatory sequences...
  23. Wu Y, Zhang Z, Zhang J, Deng Q. Association of growth factor receptor-bound protein 10 gene polymorphism with superovulation traits in Changbaishan black cattle. Genet Mol Res. 2016;15: pubmed publisher
    ..In the present study, we examined the association between a SNP of the grb10 gene and superovulation traits in cattle...
  24. Yoon M. The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling. Nutrients. 2017;9: pubmed publisher
    ..insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor ..
  25. Stevens A, Taylor M, Pearce F, Kennedy M. Allelic Dropout During Polymerase Chain Reaction due to G-Quadruplex Structures and DNA Methylation Is Widespread at Imprinted Human Loci. G3 (Bethesda). 2017;7:1019-1025 pubmed publisher
    ..for G-quadruplex formation, including AIM1, BLCAP, DNMT1, PLAGL1, KCNQ1, and GRB10 These findings demonstrate that systematic allelic dropout during PCR is a general phenomenon for regions of ..
  26. Zheng Q, Ren Y, Tzekov R, Hua S, Li M, Pang J, et al. iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery. J Ophthalmol. 2015;2015:918473 pubmed publisher
    ..21%, out of which 7 were visual cycle-associated proteins. RALBP-1, RBP-1, and IRBP were reduced in the untreated rd12 eyes and the former two were improved after gene therapy, confirmed by Western ..
  27. Lyssenko V, Groop L, Prasad R. Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk. Rev Diabet Stud. 2015;12:233-42 pubmed publisher
    ..Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes...
  28. Haig D. Frugal fat or munificent muscle: genomic imprinting and metabolism. BMC Biol. 2014;12:772 pubmed publisher
    ..A new study finds antagonistic effects of two imprinted genes, Grb10 and Dlk1, on body composition in mice...
  29. De Leonibus C, Murray P, Garner T, Hanson D, Clayton P, Stevens A. The in vitro functional analysis of single-nucleotide polymorphisms associated with growth hormone (GH) response in children with GH deficiency. Pharmacogenomics J. 2019;19:200-210 pubmed publisher
    ..For rs1024531 in GRB10, a negative regulator of IGF-I signalling and growth, the variant associated with better growth response had a ..
  30. Salvador Silva M, Ghosh S, Bertazolli Filho R, Boatright J, Nickerson J, Garwin G, et al. Retinoid processing proteins in the ocular ciliary epithelium. Mol Vis. 2005;11:356-65 pubmed
    ..proteins in the ocular ciliary epithelium (CE), and to compare in cultured ciliary epithelial cell lines promoter activities of the cellular retinaldehyde binding protein (CRALBP) and interphotoreceptor retinoid binding protein (IRBP).
  31. Gunzburg M, Kulkarni K, Watson G, Ambaye N, Del Borgo M, Brandt R, et al. Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep. 2016;6:27060 pubmed publisher
    ..83 μM) compared to G7-B1 and shows low affinity binding to Grb2-, Grb10- and Grb14-SH2 domains (KD > 100 μM)...
  32. Tezuka N, Brown A, Yanagawa S. GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. Biochem Biophys Res Commun. 2007;356:648-54 pubmed
    ..We show here that growth factor receptor-bound protein10 (GRB10), a multi-modular adaptor protein that is known to associate with several transmembrane tyrosine kinase receptors, ..
  33. Horai R, Chong W, Zhou R, Chen J, Silver P, Agarwal R, et al. Spontaneous Ocular Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific to Retina: A Tool to Dissect Mechanisms of Uveitis. Curr Mol Med. 2015;15:511-6 pubmed
    The "classical" EAU model induced by immunization of mice with the retinal protein IRBP or its peptides has been very useful to study basic mechanisms of ocular inflammation, but is inadequate for some types of studies due to the need for ..
  34. Fang C, Zhou D, Zhan S, He Y, Lin Z, Huang C, et al. [Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. Zhonghua Yan Ke Za Zhi. 2015;51:754-61 pubmed
    ..Lewis rats were immunized with interphotoreceptor retinoid-binding peptide (IRBP) in order to build the model of EAU...
  35. Liu Y, Tang Y, Ye D, Ma W, Feng S, Li X, et al. Impact of Abnormal DNA Methylation of Imprinted Loci on Human Spontaneous Abortion. Reprod Sci. 2018;25:131-139 pubmed publisher
    ..Here the DNA methylation patterns of 3 imprinted genes, including maternally inherited GRB10 and the paternally inherited IGF2 and PEG3 genes, were evaluated in human chorionic villus samples by ..
  36. McCann J, Zheng H, Islam A, Goodyer C, Polychronakos C. Evidence against GRB10 as the gene responsible for Silver-Russell syndrome. Biochem Biophys Res Commun. 2001;286:943-8 pubmed
    ..Of the several growth-related genes in this chromosomal region, only GRB10 has been demonstrated to be imprinted; however, imprinting was limited to brain and muscle and was incomplete...
  37. Zhang Y, Sun Q, Yu R, Guo J, Tang B, Yan X. The contribution of GIGYF2 to Parkinson's disease: a meta-analysis. Neurol Sci. 2015;36:2073-9 pubmed publisher
    The contribution of the gene of GIGYF2, Grb10-Interacting GYF Protein 2, to Parkinson's disease (PD) is still ambiguous...
  38. Chen J, Qian H, Horai R, Chan C, Caspi R. Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis. Curr Mol Med. 2015;15:550-7 pubmed
    ..The "classical" EAU model is induced by active immunization of mice with the retinal protein IRBP in adjuvant, and has proved to be a useful tool to study basic mechanisms and novel therapy in human uveitis...
  39. Satoh M, Namba K, Kitaichi N, Endo N, Kitamei H, Iwata D, et al. Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis. Exp Eye Res. 2016;153:79-89 pubmed publisher
    ..b>IRBP-specific Th1/Th17 cytokines were reduced in RCAI-56-treated compared with vehicle-treated mice...
  40. Takeda A, Yamada H, Hasegawa E, Arima M, Notomi S, Myojin S, et al. Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis. Jpn J Ophthalmol. 2018;62:398-406 pubmed publisher
    ..or P2rx7-deficient (P2rx7 -?- ) mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) peptide 1-20. Severity of EAU was evaluated clinically and histopathologically...
  41. Bai R, Jahn T, Schrem S, Munzert G, Weidner K, Wang J, et al. The SH2-containing adapter protein GRB10 interacts with BCR-ABL. Oncogene. 1998;17:941-8 pubmed
    ..More importantly, we identified the SH2-containing protein Grb10 as a new binding partner for Bcr-Abl...
  42. Wandu W, Tan C, Ogbeifun O, Vistica B, Shi G, Hinshaw S, et al. Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response. PLoS ONE. 2015;10:e0128906 pubmed publisher
    ..Lrrk2 (-/-) mice and their WT controls (C57Bl/6) were immunized with interphotoreceptor retinoid-binding protein (IRBP) and compared for their development of EAU, delayed type hypersensitivity (DTH) by skin tests, production of ..
  43. Iwahashi C, Fujimoto M, Nomura S, Serada S, Nakai K, Ohguro N, et al. CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: Comparison with blockade of interleukin-6. Exp Eye Res. 2015;140:53-64 pubmed publisher
    ..C57BL/6J mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) and treated once with CTLA4-Ig or MR16-1...
  44. Yang H, Zheng S, Mao Y, Chen Z, Zheng C, Li H, et al. Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis. Clin Exp Immunol. 2016;183:280-93 pubmed publisher
    ..EAU was induced with a subcutaneous injection of a mixture of interphotoreceptor retinoid binding protein (IRBP) peptide with CFA...
  45. Tode J, Richert E, Koinzer S, Klettner A, Pickhinke U, Garbers C, et al. Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. Cytokine. 2017;96:8-15 pubmed publisher
    ..EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund's adjuvant, boosted by Pertussis toxin...
  46. Cook J, Ng S, Lloyd M, Eddington S, Sun H, Nathans J, et al. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. J Biol Chem. 2017;292:21407-21416 pubmed publisher
    ..This phenotype was similar to those reported in mice that lack interphotoreceptor retinoid-binding protein (IRBP) or cellular retinol-binding protein, suggesting that peropsin plays a role in the movement of all-trans-ROL ..
  47. Hao J, Ci X, Xue H, Wu R, Dong X, Choi S, et al. Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer. Eur Urol. 2018;73:949-960 pubmed publisher
    ..Among the latter, growth factor receptor bound protein 10 (GRB10) was the most significantly and consistently upregulated gene...
  48. Frantz J, Giorgetti Peraldi S, Ottinger E, Shoelson S. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem. 1997;272:2659-67 pubmed
    ..The second protein termed hGrb-IRbeta/Grb10 contains an intact PH domain and lacks the 80-residue mGrb10 insertion...
  49. Kim M, Semple I, Kim B, Kiers A, Nam S, Park H, et al. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy. 2015;11:1358-72 pubmed publisher
    ..Through a genetic screening in Drosophila, we identified CG11148, whose product is orthologous to GIGYF1 (GRB10-interacting GYF protein 1) and GIGYF2 in mammals, as a new autophagy regulator; we hereafter refer to this gene as ..
  50. Francis M, Roche S, Cho M, Beall E, Min B, Panganiban R, et al. Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis. Proc Natl Acad Sci U S A. 2016;113:13003-13008 pubmed
    ..leucine zipper (bZIP) complex between an uncharacterized protein that we termed "Inverted Repeat Binding Protein (IRBP) 18" and its partner Xrp1...
  51. Wu W, Zhang Z, Xiong T, Zhao W, Jiang R, Chen H, et al. Calcium ion coordinated dexamethasone supramolecular hydrogel as therapeutic alternative for control of non-infectious uveitis. Acta Biomater. 2017;61:157-168 pubmed publisher
    ..efficacy to native Dex solution on an experimental autoimmune uveitis (EAU) model induced in Lewis rats with IRBP peptide and the therapeutic efficacy had in a dosage-dependent manner...
  52. Diedrichs Mohring M, Kaufmann U, Wildner G. The immunopathogenesis of chronic and relapsing autoimmune uveitis - Lessons from experimental rat models. Prog Retin Eye Res. 2018;65:107-126 pubmed publisher
    ..S-Antigen-peptide PDSAg induces chronic, monophasic disease, whilst interphotoreceptor retinoid-binding protein (IRBP)-peptide R14 causes a spontaneously relapsing-remitting course...
  53. Amaya Ramirez C, Hubbe P, Mandel N, Béthune J. 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Nucleic Acids Res. 2018;46:5792-5808 pubmed publisher
    Initially identified as a factor involved in tyrosine kinase receptor signaling, Grb10-interacting GYF protein 2 (GIGYF2) has later been shown to interact with the 5' cap-binding protein 4EHP as part of a translation repression complex, ..
  54. Liu Y, Corbett C, Klaska I, Makinen K, Nickerson J, Cornall R, et al. Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3). Exp Eye Res. 2018;172:54-65 pubmed publisher
    ..is expressed in photoreceptors under the control of the promoter for interphotoreceptor retinoid binding protein (IRBP, RBP3)...
  55. Angrist M, Bolk S, Bentley K, Nallasamy S, Halushka M, Chakravarti A. Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. Oncogene. 1998;17:3065-70 pubmed
    ..Recently, the Src homology 2 (SH2) domain-containing protein Grb10 has been shown to interact with RET in vitro and in vivo, early in development...
  56. Bak M, Boonen S, Dahl C, Hahnemann J, Mackay D, Tumer Z, et al. Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57. BMC Med Genet. 2016;17:29 pubmed publisher
    ..hypomethylation at PLAGL1 have hypomethylation at additional imprinted loci throughout the genome, including GRB10, ZIM2 (PEG3), MEST (PEG1), KCNQ1OT1 and NESPAS (GNAS-AS1)...
  57. Sember A, Bohlen J, Slechtová V, Altmanová M, Symonová R, Rab P. Karyotype differentiation in 19 species of river loach fishes (Nemacheilidae, Teleostei): extensive variability associated with rDNA and heterochromatin distribution and its phylogenetic and ecological interpretation. BMC Evol Biol. 2015;15:251 pubmed publisher
    ..tree of the analysed specimens was constructed based on one mitochondrial (cytochrome b) and two nuclear (RAG1, IRBP) genes...
  58. McKeown A, Pitale P, Kraft T. Signalling beyond photon absorption: extracellular retinoids and growth factors modulate rod photoreceptor sensitivity. J Physiol. 2016;594:1841-54 pubmed publisher
    ..Interphotoreceptor retinoid-binding protein (IRBP) is the most abundant protein in the IPM, and it promotes the removal of bleached chromophores and recycling in the ..
  59. Lee M, Li S, Sato K, Jin M. Interphotoreceptor Retinoid-Binding Protein Mitigates Cellular Oxidative Stress and Mitochondrial Dysfunction Induced by All-trans-Retinal. Invest Ophthalmol Vis Sci. 2016;57:1553-62 pubmed publisher
    Point and null mutations in interphotoreceptor retinoid-binding protein (IRBP) cause retinal dystrophy in affected patients and IRBP-deficient mice with unknown mechanism...
  60. Di Paola R, Ciociola E, Boonyasrisawat W, Nolan D, Duffy J, Miscio G, et al. Association of hGrb10 genetic variations with type 2 diabetes in Caucasian subjects. Diabetes Care. 2006;29:1181-3 pubmed
  61. Dong L, Du H, Porter S, Kolakowski L, Lee A, Mandarino L, et al. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. J Biol Chem. 1997;272:29104-12 pubmed
    ..At least two isoforms of human Grb10, (hGrb10alpha and hGrb10beta), which differ in the pleckstrin homology (PH) domain and the N-terminal sequence, ..
  62. Wick K, Werner E, Langlais P, Ramos F, Dong L, Shoelson S, et al. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem. 2003;278:8460-7 pubmed
    b>Grb10 has been proposed to inhibit or activate insulin signaling, depending on cellular context. We have investigated the mechanism by which full-length hGrb10gamma inhibits signaling through the insulin receptor substrate (IRS) proteins...
  63. Mori K, Giovannone B, Smith R. Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol. 2005;230:39-50 pubmed
    The adapter protein Grb10 binds to phosphotyrosine residues in insulin receptors via its C-terminal region and regulates insulin signaling...
  64. Liu F, Roth R. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc Natl Acad Sci U S A. 1995;92:10287-91 pubmed
    ..These findings raise the possibility that Grb-IR is a SH2-domain-containing protein that directly complexes with the IR and serves to inhibit signaling or redirect the IR signaling pathway. ..
  65. Jerome C, Scherer S, Tsui L, Gietz R, Triggs Raine B. Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12. Genomics. 1997;40:215-6 pubmed
  66. Langlais P, Dong L, Hu D, Liu F. Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family. Oncogene. 2000;19:2895-903 pubmed
    ..tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of ..
  67. Wick M, Dong L, Hu D, Langlais P, Liu F. Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. J Biol Chem. 2001;276:42843-50 pubmed
    ..tyrosine phosphorylation of the GAP-associated protein, now identified as p62(dok), is inhibited by Grb10, an adaptor protein that binds directly to the kinase domain of the IR, both in vitro and in cells...
  68. Cook K, Fadool D. Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. J Biol Chem. 2002;277:13268-80 pubmed
    ..We show that the adaptor proteins, n-Shc and Grb10, are expressed in the olfactory bulb, a region of the brain where Kv1.3 is highly expressed...
  69. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland K, Smith R. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564-73 pubmed
    ..have identified two members of a novel protein family, which become transiently linked to IGF-I receptors by the Grb10 adapter protein following IGF-I stimulation. Grb10 and GIGYFs may act cooperatively to regulate receptor signaling.
  70. Chen D, Xu L, Chen L, Li L, Zhai Z, Shu H. NIK is a component of the EGF/heregulin receptor signaling complexes. Oncogene. 2003;22:4348-55 pubmed
    ..Coimmunoprecipitation experiments demonstrated that NIK interacted with Grb7, as well as Grb10 and Grb14, but not Grb2...
  71. Kukuvitis A, Georgiou I, Syrrou M, Andronikou S, Dickerman Z, Islam A, et al. Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10. J Pediatr Endocrinol Metab. 2004;17:1215-20 pubmed
    ..As a first step in testing this hypothesis, we examined common sequence variants in IGF2R and GRB10, two genes involved in the regulation of growth and subject to parental imprinting...
  72. Desbuquois B, Carré N, Burnol A. Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins. FEBS J. 2013;280:794-816 pubmed publisher
    ..Both Grb10/14 and SH2B1/B2 associate with the activation loop of insulin/IGF-1 receptors through their SH2 domains, but ..
  73. Perdereau D, Cailliau K, Browaeys Poly E, Lescuyer A, Carré N, Benhamed F, et al. Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner. Cell Signal. 2015;27:798-806 pubmed publisher
    ..Collectively, our results show that Chfr and Grb14 collaborate in a negative feedback loop controlling insulin-stimulated cell division. ..
  74. Pandey A, Duan H, Di Fiore P, Dixit V. The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10. J Biol Chem. 1995;270:21461-3 pubmed
    ..screen of a mouse embryonic library, it was discovered that the src homology 2 (SH2) domain containing protein Grb10 bound Ret...
  75. Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, et al. Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus. J Biol Chem. 1996;271:8882-6 pubmed
    b>Grb10 is a member of a recently identified family of adapter proteins that are thought to play a role in receptor tyrosine kinase-mediated signal transduction...
  76. O Neill T, Rose D, Pillay T, Hotta K, Olefsky J, Gustafson T. Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J Biol Chem. 1996;271:22506-13 pubmed
    ..We identified a human cDNA that is a splice variant of the human GRB10 homolog GRB-IR, which we term GRB10/IR-SV1 (for GRB10/GRB-IR splice variant 1)...
  77. Morrione A, Plant P, Valentinis B, Staub O, Kumar S, Rotin D, et al. mGrb10 interacts with Nedd4. J Biol Chem. 1999;274:24094-9 pubmed
    We have utilized the yeast two-hybrid system to identify proteins interacting with mouse Grb10, an adapter protein known to interact with both the insulin and the insulin-like growth factor-I receptors...
  78. Mounier C, Lavoie L, Dumas V, Mohammad Ali K, Wu J, Nantel A, et al. Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mol Cell Endocrinol. 2001;173:15-27 pubmed
    b>Grb10 is a member of a family of adapter proteins that binds to tyrosine-phosphorylated receptors including the insulin receptor kinase (IRK)...
  79. Murdaca J, Treins C, Monthouël Kartmann M, Pontier Bres R, Kumar S, Van Obberghen E, et al. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem. 2004;279:26754-61 pubmed
    ..In a previous work, we have shown that the adaptor protein Grb10 is a positive regulator of the VEGF signaling pathway...
  80. Hsu P, Kang S, Rameseder J, Zhang Y, Ottina K, Lim D, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332:1317-22 pubmed publisher
    ..The adaptor protein Grb10 was identified as an mTORC1 substrate that mediates the inhibition of phosphoinositide 3-kinase typical of cells ..
  81. Li J, Meltzer H. A genetic locus in 7p12.2 associated with treatment resistant schizophrenia. Schizophr Res. 2014;159:333-9 pubmed publisher
    ..53 × 10(-6)). Haploview disclosed a 30 kb block flanking this SNP within GRB10, 70 kb upstream of l-dopa decarboxylase (DDC), an enzyme which is rate-limiting in the synthesis of trace amines ..
  82. Qian L, Bradford A, Cooke P, Lyons B. Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1. J Mol Recognit. 2016;29:318-33 pubmed publisher
    ..Grb7, with Grb10 and Grb14, is members of the Grb7 protein family...
  83. Sohani Z, Anand S, Robiou du Pont S, Morrison K, McDonald S, Atkinson S, et al. Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study. PLoS ONE. 2016;11:e0152107 pubmed publisher
    ..Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2, 4.85x10-3 ≤ P ≤ 4.60x10-2). Together, these 6 SNPs increase glucose by 0...
  84. Yuan H, Huang L, Hu X, Li Q, Sun X, Xie Y, et al. FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset. Orphanet J Rare Dis. 2016;11:89 pubmed publisher
    ..1 that involved the entire growth-factor receptor bound protein 10 (GRB10) gene...
  85. Surti U, Yatsenko S, Hu J, Bellissimo D, Parks W, Hoffner L. Maternal GRB10 microdeletion is a novel cause of cystic placenta: Spectrum of genomic changes in the etiology of enlarged cystic placenta. Placenta. 2017;57:33-41 pubmed publisher
    ..mosaic cases of enlarged cystic placentas and report a novel etiology, mosaicism for deletion of the maternal GRB10 gene...
  86. Ramírez Dueñas M, Medina C, Ocampo Campos R, Rivera H. Severe Silver-Russell syndrome and translocation (17;20) (q25;q13). Clin Genet. 1992;41:51-3 pubmed
    ..This observation suggests that an SRS gene(s) maps on chromosome 17 or 20 and that the patient phenotype resulted from either unmasking of heterozygosity or genomic imprinting via paternal disomy. ..
  87. Urschel S, Bassermann F, Bai R, Münch S, Peschel C, Duyster J. Phosphorylation of grb10 regulates its interaction with 14-3-3. J Biol Chem. 2005;280:16987-93 pubmed
    b>Grb10 is a member of adapter proteins that are thought to play a role in receptor tyrosine kinase-mediated signal transduction...
  88. Izzi B, Francois I, Labarque V, Thys C, Wittevrongel C, Devriendt K, et al. Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction. PLoS ONE. 2012;7:e38579 pubmed publisher
    ..Since some AHO features are present in other imprinting disorders, the methylation of IGF2, H19, SNURF and GRB10 was quantified. Surprisingly, significant IGF2 hypermethylation (20 ± 10 vs. 14 ± 7%; p<0...
  89. Xu H, Yang W, Pérez Andreu V, Devidas M, Fan Y, Cheng C, et al. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst. 2013;105:733-42 pubmed publisher
    ..These findings indicate strong associations between inherited genetic variation and ALL susceptibility in children and shed new light on ALL molecular etiology in diverse ancestry. ..
  90. Yang F, Ma H, Belcher J, Butler M, Redmond T, Boye S, et al. Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2016;30:4313-4325 pubmed
    ..Subretinal delivery of AAV5-IRBP/GNAT2-DIO3, which directs expression of human DIO3 specifically in cones, increased cone density by 30-40% in a ..
  91. Yan X, Himburg H, Pohl K, Quarmyne M, Tran E, Zhang Y, et al. Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. Cell Rep. 2016;17:1584-1594 pubmed publisher
    ..Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regeneration...
  92. Li H, Gao S, Huang H, Liu W, Huang H, Liu X, et al. High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells. Oncotarget. 2017;8:47344-47355 pubmed publisher
    ..Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells.