GPX3

Summary

Gene Symbol: GPX3
Description: glutathione peroxidase 3
Alias: GPx-P, GSHPx-3, GSHPx-P, glutathione peroxidase 3, GPx-3, extracellular glutathione peroxidase, glutathione peroxidase 3 (plasma), plasma glutathione peroxidase
Species: human
Products:     GPX3

Top Publications

  1. Yoshimura S, Suemizu H, Taniguchi Y, Arimori K, Kawabe N, Moriuchi T. The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32. Gene. 1994;145:293-7 pubmed
    A genomic clone encoding the human plasma glutathione peroxidase (PGPx), a major enzyme in reducing lipid hydroperoxide and hydrogen peroxide in plasma, was isolated and 5618 nucleotides (nt) were determined...
  2. Bierl C, Voetsch B, Jin R, Handy D, Loscalzo J. Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem. 2004;279:26839-45 pubmed
    b>Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. GPx-3 deficiency has been associated with cardiovascular disease and stroke...
  3. Lee O, Schneider Stock R, McChesney P, Kuester D, Roessner A, Vieth M, et al. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia. 2005;7:854-61 pubmed
    ..Glutathione peroxidase-3 (GPx3) is a secretory protein with potent extracellular antioxidant activity...
  4. Yu Y, Yu G, Tseng G, Cieply K, Nelson J, DeFrances M, et al. Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res. 2007;67:8043-50 pubmed
    b>Glutathione peroxidase 3 is a selenium-dependent enzyme playing a critical role in detoxifying reactive oxidative species and maintaining the genetic integrity of mammalian cells...
  5. Zhang X, Yang J, Kim Y, Kim K, Ahn W, Yang S. An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. Int J Oncol. 2010;36:405-14 pubmed
    ..The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer...
  6. He Y, Wang Y, Li P, Zhu S, Wang J, Zhang S. Identification of GPX3 epigenetically silenced by CpG methylation in human esophageal squamous cell carcinoma. Dig Dis Sci. 2011;56:681-8 pubmed publisher
    ..b>GPX3 was selected as a novel candidate hypermethylated gene in ESCC through microarray analysis...
  7. Chen B, Rao X, House M, Nephew K, Cullen K, Guo Z. GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response. Cancer Lett. 2011;309:37-45 pubmed publisher
    b>Glutathione peroxidase 3 (GPx3), a plasma antioxidant enzyme, maintains genomic integrity by inactivating reactive oxygen species (ROS), known DNA-damaging agents and mediators of cancer chemotherapy response...
  8. Wang H, Luo K, Tan L, Ren B, Gu L, Michalopoulos G, et al. p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. J Biol Chem. 2012;287:16890-902 pubmed publisher
    Expression of glutathione peroxidase 3 (GPx3) is down-regulated in a variety of human malignancies. Both methylation and deletion of GPx3 gene underlie the alterations of GPx3 expression in prostate cancer...
  9. Herault O, Hope K, Deneault E, Mayotte N, Chagraoui J, Wilhelm B, et al. A role for GPx3 in activity of normal and leukemia stem cells. J Exp Med. 2012;209:895-901 pubmed publisher
    ..We report that expression of the reactive oxygen species (ROS) scavenger glutathione peroxidase 3 (GPx3) positively correlates with the frequency of leukemia stem cells (LSCs) in Hoxa9+Meis1-induced ..

More Information

Publications115 found, 100 shown here

  1. Peng D, Hu T, Schneider B, Chen Z, Xu Z, El Rifai W. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS ONE. 2012;7:e46214 pubmed publisher
    ..b>Glutathione peroxidase 3 (GPX3), a plasma GPX member and a major scavenger of ROS, catalyzes the reduction of hydrogen peroxide ..
  2. Zhang X, Zheng Z, Yingji S, Kim H, Jin R, Renshu L, et al. Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer. Oncol Rep. 2014;31:2587-92 pubmed publisher
    Glutathione peroxidase 3 (GPX3) is a member of the glutathione peroxidase family of selenoproteins and is one of the key defensive enzymes against oxidative damages to host cells...
  3. Liang Y, Batistel F, Parys C, Loor J. Glutathione metabolism and nuclear factor erythroid 2-like 2 (NFE2L2)-related proteins in adipose tissue are altered by supply of ethyl-cellulose rumen-protected methionine in peripartal Holstein cows. J Dairy Sci. 2019;: pubmed publisher
    ..supply of Met resulted in an overall upregulation of protein abundance of glutathione peroxidase (GPX) 1, GPX3, glutathione S-transferase mu 1 (GSTM1), and glutathione S-transferase α 4 (GSTA4), all related to GSH metabolism...
  4. Subramaniam E, Colazo M, Gobikrushanth M, Sun Y, Ruiz Sanchez A, Ponce Barajas P, et al. Effects of reducing dietary starch content by replacing barley grain with wheat dried distillers grains plus solubles in dairy cow rations on ovarian function. J Dairy Sci. 2016;99:2762-2774 pubmed publisher
    ..Diets did not alter the expression profiles of LHr, estrogen receptor β, CYP19, and GPx3 genes in granulosa cells...
  5. Sun L, Zhang N, Zhu M, Zhao L, Zhou J, Qi D. Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver. J Nutr. 2016;: pubmed
    ..Dietary selenium supplementation increased (P < 0.05) mRNA and/or activities of 6 selenoprotein genes (Gpx3, Txnrd1, Txnrd2, Txnrd3, iodothyronine deiodinase 2, and selenoprotein N) in the liver of AFB1-treated ..
  6. Park E, Park S, Cho I, Kim B, Schuller Levis G. A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Taurine Distribution in Various Tissues With and Without Taurine Supplementation. Adv Exp Med Biol. 2017;975 Pt 1:461-474 pubmed publisher
    ..The expression of glutathione peroxidase 3 was increased in the brain and peroxireductase 2 was increased in the liver and lung, suggesting taurine ..
  7. Li P, Hsu C, Yin M, Kuo Y, Tang F, Chao C. Protective Effects of Red Guava on Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Mice. Molecules. 2015;20:22341-50 pubmed publisher
    ..inflammatory proteins, such as iNOS and NF-κB, was suppressed via activated PPARγ, and the expression levels of GPx3 and ACO increased...
  8. Chu K, Chan K, Yang Y, Qin Y, Li W, Chan S, et al. Effects of EGCG content in green tea extract on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues. J Nutr Biochem. 2015;26:1357-67 pubmed publisher
    ..Our results reveal pro-oxidation of GTE with high EGCG content to the ocular tissues. Optimal EGCG level is needed for protection. ..
  9. Föger Samwald U, Vekszler G, Hörz Schuch E, Salem S, Wipperich M, Ritschl P, et al. Molecular mechanisms of osteoporotic hip fractures in elderly women. Exp Gerontol. 2016;73:49-58 pubmed publisher
    ..and a significantly increased expression of the enzymes superoxide dismutase 2 (SOD2) and glutathione peroxidase GPX3, and of the inflammatory cytokine IL6 in bone samples from hip fracture patients compared to controls...
  10. Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T, et al. Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium Oxalate Stone Formers. J Am Soc Nephrol. 2017;28:333-347 pubmed publisher
    ..Compared with non-RP tissue, RP tissue showed upregulation (?2-fold) of LCN2, IL11, PTGS1, GPX3, and MMD and downregulation (0.5-fold) of SLC12A1 and NALCN (P<0.01)...
  11. Sunde R, Sunde G, Sunde C, Sunde M, Evenson J. Cloning, Sequencing, and Expression of Selenoprotein Transcripts in the Turkey (Meleagris gallopavo). PLoS ONE. 2015;10:e0129801 pubmed publisher
    ..RTPCR was used to determine the relative transcript expression in 6 tissues. GPX3 expression was high in all tissues except kidney, GPX1 expression was high in kidney, SEPW1 expression was high in ..
  12. Endres L, Begley U, Clark R, Gu C, Dziergowska A, Małkiewicz A, et al. Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage. PLoS ONE. 2015;10:e0131335 pubmed publisher
    ..expression of selenocysteine-containing ROS detoxification enzymes belonging to the glutathione peroxidase (Gpx1, Gpx3, Gpx6 and likely Gpx4) and thioredoxin reductase (TrxR1) families...
  13. Rollet Cohen V, Bourderioux M, Lipecka J, Chhuon C, Jung V, Mesbahi M, et al. Comparative proteomics of respiratory exosomes in cystic fibrosis, primary ciliary dyskinesia and asthma. J Proteomics. 2018;185:1-7 pubmed publisher
    ..Differential Proteomic profiles of exosomes isolated from BAL from CF, PCD and asthmatic patients suggest that they carry pro-inflammatory proteins that may be involved in the progression of lung damage. ..
  14. Goodla L, Manubolu M, Pathakoti K, Jayakumar T, Sheu J, Fraker M, et al. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..analyses revealed that significant alterations in superoxide dismutase (SOD1), glutathione peroxidase (GPx2, GPx3), and catalase (CAT) occurred in rats that were exposed to CCl4 and restored post EEAB treatment...
  15. Xu C, Zuo Z, Liu K, Jia H, Zhang Y, Luo H. Transcriptome analysis of the Tan sheep testes: Differential expression of antioxidant enzyme-related genes and proteins in response to dietary vitamin E supplementation. Gene. 2016;579:47-51 pubmed publisher
    ..05) the mRNA and protein expression of Glutathione peroxidase 3 and Glutathione S-transferase alpha 1...
  16. Wu W, Maneix L, Insunza J, Nalvarte I, Antonson P, Kere J, et al. Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate. Proc Natl Acad Sci U S A. 2017;114:E3816-E3822 pubmed publisher
    ..The most down-regulated genes were the following: the antioxidant gene glutathione peroxidase 3; protease inhibitors WAP four-disulfide core domain 3 (WFDC3); the tumor-suppressive genes T-cadherin and ..
  17. Alibakhshi T, Khodayar M, Khorsandi L, Rashno M, Zeidooni L. Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity. Biomed Pharmacother. 2018;105:225-232 pubmed publisher
    ..However, our findings suggest that zingerone has nephroprotective effects in cisplatin rat model of nephrotoxicity mostly through suppression of oxidative stress and inflammation. ..
  18. Marco Ramell A, Arroyo L, Peña R, Pato R, Saco Y, Fraile L, et al. Biochemical and proteomic analyses of the physiological response induced by individual housing in gilts provide new potential stress markers. BMC Vet Res. 2016;12:265 pubmed
    ..galectin 1 were also identified by iTRAQ, as well as oxidative stress enzymes such as peroxiredoxin 2 and glutathione peroxidase 3. Proteomics also revealed the decrease of apolipoproteins, and the presence of intracellular proteins in ..
  19. Badalzadeh R, Yavari R, Chalabiani D. Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts. Gen Physiol Biophys. 2015;34:323-9 pubmed publisher
    ..In conclusion, opening of mitochondrial ATP-sensitive K(+) channels and attenuating of oxidative stress can be suggested as underlying mechanisms for cardioprotective effect of diosgenin in I/R injury. ..
  20. Arumugam T, Pillay Y, Ghazi T, Nagiah S, Abdul N, Chuturgoon A. Fumonisin B1-induced oxidative stress triggers Nrf2-mediated antioxidant response in human hepatocellular carcinoma (HepG2) cells. Mycotoxin Res. 2019;35:99-109 pubmed publisher
    ..05); however, the expression of Sirt 3 and Lon-P1 (p ≤ 0.001) were upregulated. Exposure to FB1 induced oxidative stress in HepG2 cells and initiated Nrf2-regulated transcription of antioxidants. ..
  21. Al Naqeb G, Rousova J, Kubatova A, Picklo M. Pulicaria jaubertii E. Gamal-Eldin reduces triacylglyceride content and modifies cellular antioxidant pathways in 3T3-L1 adipocytes. Chem Biol Interact. 2016;253:48-59 pubmed publisher
    ..Activity towards depleting GSH and elevating the expression of catalase and GPx3 were found in the DCM and hexane fractions...
  22. Zhang P, Guan X, Yang M, Zeng L, Liu C. Roles and potential mechanisms of selenium in countering thyrotoxicity of DEHP. Sci Total Environ. 2018;619-620:732-739 pubmed publisher
    ..DEHP disrupted the redox equilibrium, causing depletions of SOD, GPx1, GPx3, and TxnRd, and accumulations of MDA. Nevertheless, selenium supplementation effectively improved the redox status...
  23. Jiang X, Cao C, Li Z, Li W, Zhang C, Lin J, et al. Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system. J Inorg Biochem. 2017;169:13-22 pubmed publisher
    ..and Selenoprotein T (Selt), Selenoprotein K (Selk), Selenoprotein W (Selw), Selenoprotein U (Selu), Glutathione peroxidase 3 (Gpx3), Glutathione peroxidase 4 (Gpx4), Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein ..
  24. Heim D, Gil Ibanez I, Herden J, Parplys A, Borgmann K, Schmidt Arras D, et al. Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response. Oncotarget. 2016;7:55639-55648 pubmed publisher
    ..oncogenic mechanism, we detected a decreased expression of antioxidant genes, in particular glutathione peroxidase 3 and apolipoprotein E, and an absence of P21 upregulation following ROS-conferred induction of DSB...
  25. Al Ghamdi A, Elansary H. Synergetic effects of 5-aminolevulinic acid and Ascophyllum nodosum seaweed extracts on Asparagus phenolics and stress related genes under saline irrigation. Plant Physiol Biochem. 2018;129:273-284 pubmed publisher
    ..ANN1, ANN2 and PIP1), secondary metabolite production (P5CS1 and CHS) and antioxidants accumulation (APX1 and GPX3) in plants...
  26. Dalto D, Roy M, Audet I, Palin M, Guay F, Lapointe J, et al. Interaction between vitamin B6 and source of selenium on the response of the selenium-dependent glutathione peroxidase system to oxidative stress induced by oestrus in pubertal pig. J Trace Elem Med Biol. 2015;32:21-9 pubmed publisher
    ..01). Gene expressions of GPX1, GPX3, GPX4, and selenocysteine lyase in liver and kidney were greatest in OSeB610 gilts (p<0.05)...
  27. Wen L, Liu Y, Jiang C, Zeng S, Su Y, Wu W, et al. Comparative Proteomic Profiling and Biomarker Identification of Traditional Chinese Medicine-Based HIV/AIDS Syndromes. Sci Rep. 2018;8:4187 pubmed publisher
    ..the TCM syndrome-specific DEPs were confirmed as biomarkers based on western blot analyses, including FN1, GPX3, KRT10 for AHT and RBP4, ApoE, KNG1 for YDSK...
  28. Costa T, Amstalden M, Ribeiro D, Menaldo D, Sartim M, Aissa A, et al. CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress. Toxicology. 2018;404-405:42-48 pubmed publisher
    ..In addition, two genes of the antioxidant pathway were upregulated (GPX3 and MPO), probably in an attempt to protect tumor cells from oxidative damage...
  29. Liu K, Jin M, Xiao L, Liu H, Wei S. Distinct prognostic values of mRNA expression of glutathione peroxidases in non-small cell lung cancer. Cancer Manag Res. 2018;10:2997-3005 pubmed publisher
    ..In contrast, high expression of GPx3 mRNA was associated with better OS for all NSCLC patients...
  30. Pastor F, Dumas K, Barthélémy M, Regazzetti C, Druelle N, Peraldi P, et al. Implication of REDD1 in the activation of inflammatory pathways. Sci Rep. 2017;7:7023 pubmed publisher
    ..Absence of REDD1 decreases ROS associated with a dysregulation of Nox-1 and GPx3 expression...
  31. Usuki F, Fujimura M. Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity. Arch Toxicol. 2016;90:917-26 pubmed publisher
    ..Plasma selenium-dependent glutathione peroxidase (GPx3) activity also significantly decreased after MeHg exposure, whereas plasma non-selenoenzyme glutathione reductase ..
  32. Lin J, Kuo W, Chiang F, Hsiao P, Lee K, Wu C, et al. Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer. Surgery. 2009;145:508-13 pubmed publisher
    The antioxidant enzyme glutathione peroxidase 3 (GPX3) can lessen the oxidative stress in the thyroid gland...
  33. Westphal K, Stangl V, Fähling M, Dreger H, Weller A, Baumann G, et al. Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells. Free Radic Biol Med. 2009;47:1652-60 pubmed publisher
    ..As GPx-3 is secreted into the plasma, our data point toward a borderline defense mechanism of endothelial cell-derived GPx-3 to protect the vasculature from oxidative stress. ..
  34. Zhou J, Wen X, Zhang Y, Yang L, Ma Y, Ma J, et al. Down-regulation of GPX3 is associated with favorable/intermediate karyotypes in de novo acute myeloid leukemia. Int J Clin Exp Pathol. 2015;8:2384-91 pubmed
    Decreased glutathione peroxidase 3 (GPX3) expression has been identified in numerous solid tumors. However, GPX3 expression pattern in acute myeloid leukemia (AML) remains poorly known...
  35. Meng L, Rijntjes E, Swarts H, Bunschoten A, van der Stelt I, Keijer J, et al. Dietary-Induced Chronic Hypothyroidism Negatively Affects Rat Follicular Development and Ovulation Rate and Is Associated with Oxidative Stress. Biol Reprod. 2016;94:90 pubmed publisher
    ..reductase 1 ( ITALIC! Txnrd1), and uncoupling protein 2 ( ITALIC! Ucp2) and a downward trend in glutathione peroxidase 3 ( ITALIC! Gpx3) and glutathione S-transferase mu 2 ( ITALIC! Gstm2) expression...
  36. Zhu S, Li X, Sun X, Lin J, Li W, Zhang C, et al. Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure-function relationships and interactions of binding molecules. Metallomics. 2017;9:124-131 pubmed publisher
    ..selenoproteins (GPx1-4), FAD-interacting selenoproteins (TrxR1-3), secretory transport selenoproteins (GPx3 and SelPa) and other selenoproteins...
  37. Wieczorek E, Jablonowski Z, Tomasik B, Gromadzinska J, Jablonska E, Konecki T, et al. Different Gene Expression and Activity Pattern of Antioxidant Enzymes in Bladder Cancer. Anticancer Res. 2017;37:841-848 pubmed
    ..The activity of glutathione peroxidase 3 (GPX3) was examined in plasma, and GPX1 and copper-zinc containing superoxide dismutase 1 (SOD1) in ..
  38. Maharajan K, Muthulakshmi S, Nataraj B, Ramesh M, Kadirvelu K. Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): A multi biomarker study. Aquat Toxicol. 2018;196:132-145 pubmed publisher
    ..Hence, the results of the present study demonstrate that PPF could cause adverse effect on early developmental stages of zebrafish at higher concentration. ..
  39. Maldonado L, Brait M, Loyo M, Sullenberger L, Wang K, Peskoe S, et al. GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer. J Urol. 2014;192:1542-8 pubmed publisher
    ..methylation of genes previously reported as aberrantly methylated in prostate cancer (AIM1, APC, CCND2, GPX3, GSTP1, MCAM, RARβ2, SSBP2 and TIMP3) by quantitative fluorogenic methylation-specific polymerase chain reaction...
  40. Zhang J, Xu B, Huang X, Gao Y, Chen Y, Shan A. Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks. Biol Trace Elem Res. 2016;171:201-7 pubmed publisher
    ..The mRNA levels of 14 selenoprotein genes (Dio1, Dio2, GPx3, Sepp1, SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (..
  41. Liu H, Huang Y, Cheng S, Huang Y, Lin P. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutr J. 2016;15:85 pubmed
    ..Clinical Trials.gov Identifier: NCT01964001. ..
  42. Lan X, Xing J, Gao H, Li S, Quan L, Jiang Y, et al. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Biol Trace Elem Res. 2017;178:22-28 pubmed publisher
    ..The expression of 25 selenoprotein genes (Dio1, Dio2, Dio3, Gpx1, Gpx2, Gpx3, Gpx4, Gpx6, SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelS, SelT, SelV, SelW, SelX, Sel15, Sps2, TR1, TR2, and TR3)..
  43. Burk R, Hill K, Motley A, Byrne D, Norsworthy B. Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: a randomized controlled trial. Am J Clin Nutr. 2015;102:1126-33 pubmed publisher
    ..Plasma SEPP1 concentration and glutathione peroxidase (GPX) activity, the latter due largely to the selenoprotein GPX3 secreted by the kidneys, were measured before and after supplementation...
  44. Gao H, Liu C, Song S, Fu J. Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken. Biol Trace Elem Res. 2016;172:234-41 pubmed publisher
    ..In the sword cartilage, Se alleviated the downtrend of the expression of Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Dio2, Dio3, Seli, Selh, SPS2, Sepx1, Selk, Selw, Selo, Selm, Sep15, Selpb, Sepn1, and Selt ..
  45. Liguori M, Nuzziello N, Licciulli F, Consiglio A, Simone M, Gemma Viterbo R, et al. Combined microRNAs and mRNAs expression analysis in Pediatric Multiple Sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease. Hum Mol Genet. 2017;: pubmed publisher
    ..e. ATG16L1, SORT1, LAMP2) and ATPase activity (i.e. ABCA1, GPX3). No significant molecular profiles were associated with any PedMS demographic/clinical features...
  46. Comhair S, Bhathena P, Farver C, Thunnissen F, Erzurum S. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J. 2001;15:70-78 pubmed
    ..on the airway epithelial surface against reactive oxygen and nitrogen species (ROS and RNS) is extracellular glutathione peroxidase (eGPx)...
  47. Zhao H, Li J, Li X, Han C, Zhang Y, Zheng L, et al. Silencing GPX3 Expression Promotes Tumor Metastasis in Human Thyroid Cancer. Curr Protein Pept Sci. 2015;16:316-21 pubmed
    The incidence of thyroid cancer has been increased in the past few decades. GPX3 gene is located in 5q23, which is frequently deleted in prostate cancer...
  48. Kanno S, Tomizawa A, Yomogida S. Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR. Biol Pharm Bull. 2016;39:440-5 pubmed publisher
    ..Ttr) and metallothionein 1 (Mt1) showed increases in the liver injury group, while those of the glutathione peroxidase 3-encoding locus (Gpx3) were decreased...
  49. Mao J, Vanderlelie J, Perkins A, Redman C, Ahmadi K, Rayman M. Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women. Am J Clin Nutr. 2016;103:100-6 pubmed publisher
    ..at 12 and 35 wk of gestation, the concentration of toenail selenium at 16 wk of gestation, and plasma glutathione peroxidase (GPx3) activity at 12 and 35 wk of gestation...
  50. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..8-fold], and selenoprotein glutathione peroxidase 3 (GPX3; 1.4-fold) and suppressed (P < 0...
  51. Wu W, Wang Q, Yin F, Yang Z, Zhang W, Gabra H, et al. Identification of proteomic and metabolic signatures associated with chemoresistance of human epithelial ovarian cancer. Int J Oncol. 2016;49:1651-65 pubmed publisher
    ..Among them, FN1, SERPINA1, GPX3 and ORM1 were chosen for western blotting and ELISA validation...
  52. Sunde R, Zemaitis E, Blink A, Lawinger J. Impact of Glutathione Peroxidase-1 (Gpx1) Genotype on Selenoenzyme and Transcript Expression When Repleting Selenium-Deficient Mice. Biol Trace Elem Res. 2018;186:174-184 pubmed publisher
    ..Se deficiency decreased the activities of plasma Gpx3, liver Gpx1, liver Txnrd, and liver Gpx4 to 3, 0...
  53. Maddipati K, Marnett L. Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase. J Biol Chem. 1987;262:17398-403 pubmed
    ..The human plasma glutathione peroxidase is a tetramer of identical subunits of 21...
  54. Takahashi K, Avissar N, Whitin J, Cohen H. Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme. Arch Biochem Biophys. 1987;256:677-86 pubmed
    ..Radioimmunoassay utilizing erythrocyte GSHPx and anti-erythrocyte GSHPx antibodies showed that less than 0.13% of the antigenically detectable protein is found in the purified GSHPx from plasma. ..
  55. Yang C, Hao R, Deng Y, Liao Y, Wang Q, Sun R, et al. Effects of protein sources on growth, immunity and antioxidant capacity of juvenile pearl oyster Pinctada fucata martensii. Fish Shellfish Immunol. 2017;67:411-418 pubmed publisher
    ..05). Results suggested the suitability of Chlorella sp. powder, S. platensis powder, yeast powder and soybean meal as protein sources for development of formulated diets for pearl oyster P. f. martensii. ..
  56. Cao L, Zhang L, Zeng H, Wu R, Wu T, Cheng W. Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice. J Nutr. 2017;147:1858-1866 pubmed publisher
    ..selenoprotein W (Selenow), methionine-R-sulfoxide reductase 1 (MsrB1), Gpx1, Gpx3, thioredoxin reductase 1 (Txnrd1), Txnrd2, selenoprotein S (Selenos), selenoprotein F (..
  57. Zheng X, Ning C, Dong Y, Zhao P, Li J, Fan Z, et al. Quantitative proteome analysis of bovine mammary gland reveals protein dynamic changes involved in peak and late lactation stages. Biochem Biophys Res Commun. 2017;494:292-297 pubmed publisher
    ..and SFRP4) and nine functional well-studies known proteins (PLIN2, LPIN1, PLIN3, GSN, CD74, MMP2, SOD1, SOD3 and GPX3) related to milk performance and mammary morphology...
  58. Chu F, Esworthy R, Doroshow J, Doan K, Liu X. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Blood. 1992;79:3233-8 pubmed
    We analyzed the expression of plasma glutathione peroxidase (GSHPx-P) messenger RNA (mRNA) in mouse, rat, and human tissues, using a human GSHPx-P cDNA clone as the probe...
  59. Hao Y, Wu B, Shi J, Chen Y, Sun Z, Zheng L, et al. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Chin Med J (Engl). 2011;124:2113-6 pubmed
    ..045, OR: 0.833, 95%CI: 0.695 - 0.998). The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning. ..
  60. Farimani Sanoee M, Alizamir T, Faramarzi S, Saidijam M, Yadegarazari R, Shabab N, et al. Effect of myomectomy on endometrial glutathione peroxidase 3 (GPx3) and glycodelin mRNA expression at the time of the implantation window. Iran Biomed J. 2014;18:60-6 pubmed
    In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas...
  61. Tuft Stavnes H, Nymoen D, Hetland Falkenthal T, Kærn J, Trope C, Davidson B. APOA1 mRNA expression in ovarian serous carcinoma effusions is a marker of longer survival. Am J Clin Pathol. 2014;142:51-7 pubmed publisher
    We previously described the overexpression of APOA1 and GPX3 in ovarian/peritoneal serous carcinoma compared with breast carcinoma effusions using gene expression array analysis...
  62. Akhter M, Biswas A, Rashid H, Devi L, Behari M, Saxena R. Screening of the GPX3 gene identifies the "T" allele of the SNP -861A/T as a risk for ischemic stroke in young Asian Indians. J Stroke Cerebrovasc Dis. 2014;23:2060-2068 pubmed publisher
    Deficiency of plasma glutathione peroxidase (GPx-3) has been associated with platelet-dependent thrombosis...
  63. Iorio A, Velocci M, Graziano M, Piacentini S, Polimanti R, Manfellotto D, et al. GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients. Clin Exp Pharmacol Physiol. 2016;43:277-9 pubmed publisher
  64. Starodubtseva N, Kononikhin A, Bugrova A, Chagovets V, Indeykina M, Krokhina K, et al. Investigation of urine proteome of preterm newborns with respiratory pathologies. J Proteomics. 2016;149:31-37 pubmed publisher
    ..including: proteins involved in cell adhesion (CDH-2,-5,-11, NCAM1, TRY1, DSG2), metabolism (LAMP1, AGRN, TPP1, GPX3, APOD, CUBN, IDH1), regulation of enzymatic activity (SERPINA4, VASN, GAPDH), inflammatory and stress response (..
  65. Youm J, Kim S, Jee B, Kim S. Embryonic survival, development and cryoinjury of repeatedly vitrified mouse preimplantation embryos. Eur J Obstet Gynecol Reprod Biol. 2017;217:66-70 pubmed publisher
    ..From hatching/hatched blastocysts, the mRNA expressions for Cirbp, Casp3, Sod1, Gpx3, and Cat were quantified by real-time quantitative RT-PCR...
  66. Benyamin B, He J, Zhao Q, Gratten J, Garton F, Leo P, et al. Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nat Commun. 2017;8:611 pubmed publisher
    ..We find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1...
  67. Peters U, Chatterjee N, Hayes R, Schoen R, Wang Y, Chanock S, et al. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2008;17:1144-54 pubmed publisher
    ..We genotyped 44 tagging single nucleotide polymorphisms (SNP) in six genes [glutathione peroxidase 1-4 (GPX1, GPX2, GPX3, and GPX4), selenoprotein P (SEPP1), and thioredoxin reductase 1 (TXNRD1)] to efficiently predict common variation ..
  68. Polimanti R, Fuciarelli M, Destro Bisol G, Battaggia C. Functional diversity of the glutathione peroxidase gene family among human populations: implications for genetic predisposition to disease and drug response. Pharmacogenomics. 2013;14:1037-45 pubmed publisher
    ..Asian patients of haplotypes associated with normal functionality is significantly higher for GPX1 and lower for GPX3 than for non-Asian patients; no adaptation signals in GPX1 and GPX3 were found in Asian patients...
  69. Li M, Li J, Wei C, Lu Q, Tang X, Erickson S, et al. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects. Ann Hum Genet. 2016;80:20-31 pubmed publisher
    ..13e-07). These three variants are located within genes BHMT2, GSTP1, and GPX3, respectively...
  70. Comhair S, Thomassen M, Erzurum S. Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke. Am J Respir Cell Mol Biol. 2000;23:350-4 pubmed
    ..g., nitric oxide (NO). Extracellular glutathione peroxidase (eGPx) is synthesized by airway epithelium and alveolar macrophages, secreted into the surface ..
  71. Richard M, Guiraud P, Didier C, Seve M, Flores S, Favier A. Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. Arch Biochem Biophys. 2001;386:213-20 pubmed
    ..All these disturbances, as well as the previously described decrease in Mn superoxide dismutase activity, are part of the viral strategy to modify the redox potential of cells and may have important consequences for patients. ..
  72. Shastry B. Evaluation of the ABCR and glutathione peroxidase-3 genes in familial and sporadic cases of exudative age-related macular degeneration. Int J Mol Med. 2004;14:753-7 pubmed
    ..In addition, one of the susceptible loci for maculopathy is on chromosome 5 that is very close to the plasma glutathione peroxidase (GPX) gene...
  73. Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S, et al. Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep. 2008;20:1299-303 pubmed
    ..Six genes including the glutathione peroxidase 3 (GPX3) gene were identified to be highly expressed in clear cell adenocarcinoma by DNA microarray ..
  74. Baez Duarte B, Zamora Ginez I, Mendoza Carrera F, Ruiz Vivanco G, Torres Rasgado E, Gonzalez Mejia M, et al. Serum levels of glutathione peroxidase 3 in overweight and obese subjects from central Mexico. Arch Med Res. 2012;43:541-7 pubmed publisher
    ..It has been reported that glutathione peroxidase 3 (GPx3), an extracellular enzyme involved in the reduction of both hydro- and lipoperoxides, shows changes ..
  75. Huang X, Hao C, Shen X, Zhang Y, Liu X. RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients. Reprod Biol Endocrinol. 2013;11:109 pubmed publisher
    ..genes which had been found to be associated with oocyte maturation or embryo quality in non-PCOS patients (GPX3 and PTX3) were also studied. The mRNA expression levels of cumulus cells were detected by qRT- PCR...
  76. Baez Duarte B, Mendoza Carrera F, García Zapién A, Flores Martinez S, Sanchez Corona J, Zamora Ginez I, et al. Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome. Arch Med Res. 2014;45:375-82 pubmed publisher
    b>Glutathione peroxidase 3 (GPx3) plays a main role in removing hydro- and lipoperoxides from the body...
  77. Cao S, Yan B, Lu Y, Zhang G, Li J, Zhai W, et al. Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue. Clin Res Hepatol Gastroenterol. 2015;39:198-204 pubmed publisher
    ..The role of aberrant methylation of the GPX3 promoter in hepatocellular carcinoma (HCC) is not yet clear...
  78. Item C, Escueta S, Schanzer A, Farhadi S, Metz T, Zeyda M, et al. Demethylation of the promoter region of GPX3 in a newborn with classical phenylketonuria. Clin Biochem. 2017;50:159-161 pubmed publisher
    ..bond guanine positions of an overlapping CCAAT box/metal response element (CGATTGGCTG) of the glutathione peroxidase 3 promoter activated by oxidative stimuli and expressed in plasma were analysed for methylation changes in ..
  79. Ehnert S, Fentz A, Schreiner A, Birk J, Wilbrand B, Ziegler P, et al. Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2- and H2O2. Sci Rep. 2017;7:14544 pubmed publisher
    ..ELF-PEMF exposure induced expression of GPX3, SOD2, CAT and GSR on mRNA, protein and enzyme activity level...
  80. Pang P, Abbott M, Abdi M, Fucci Q, Chauhan N, Mistri M, et al. Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant. 2017;: pubmed publisher
    Chronic kidney disease (CKD) patients have deficient levels of glutathione peroxidase-3 (GPx3)...
  81. Martín Alonso J, Ghosh S, Coca Prados M. Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye. J Biochem. 1993;114:284-91 pubmed
    ..This report details the results of a study of molecular cloning, sequencing, and expression of plasma glutathione peroxidase (GPx-P) from the bovine ocular ciliary epithelium...
  82. Chu F. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. Cytogenet Cell Genet. 1994;66:96-8 pubmed
    ..GSHPx) genes, including the classic GPX1 (GSHPx-1), the newly characterized GPX2 (GSHPx-GI), the plasma enzyme GPX3 (GSHPx-P), and the phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPX), were hybridized to Southern ..
  83. Eiselt J, Racek J, Opatrny K. Oxidative stress: the effect of erythropoietin and the dialysis membrane. Int J Artif Organs. 2000;23:33-40 pubmed
    ..HD using the H as well as the PS membrane is accompanied by oxidative stress...
  84. Ortac E, Ozkaya O, Saraymen R, Yildiz N, Bedir A, Buyan N, et al. Low hair selenium and plasma glutathione peroxidase in children with chronic renal failure. Pediatr Nephrol. 2006;21:1739-45 pubmed
    ..The lack of any relation between plasma GSH-Px and hair Se suggests that plasma GSH-Px is not a good marker of Se stores. ..
  85. Voetsch B, Jin R, Bierl C, Benke K, Kenet G, Simioni P, et al. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke. 2007;38:41-9 pubmed
    b>Plasma glutathione peroxidase (GPx-3)-deficiency increases extracellular oxidant stress, decreases bioavailable nitric oxide, and promotes platelet activation...
  86. Voetsch B, Jin R, Bierl C, Deus Silva L, Camargo E, Annichino Bizacchi J, et al. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Stroke. 2008;39:303-7 pubmed
    b>Plasma glutathione peroxidase (GPx-3) is a major antioxidant enzyme in plasma and the extracellular space that scavenges reactive oxygen species produced during normal metabolism or after oxidative insult...
  87. Nowak Gottl U, Fiedler B, Huge A, Niederstadt T, Thedieck S, Seehafer T, et al. Plasma glutathione peroxidase in pediatric stroke families. J Thromb Haemost. 2011;9:33-8 pubmed publisher
    Promoter polymorphisms in the plasma glutathione peroxidase gene (GPX3), which encodes a major antioxidant enzyme implicated in post-translational modification of fibrinogen, have been implicated as risk factors for arterial ischemic ..
  88. Chen H, Zheng Z, Kim K, Jin X, Roh M, Jin Z. Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma. Oncol Rep. 2016;36:2737-2744 pubmed publisher
    As a crucial antioxidant enzyme, glutathione peroxidase 3 (GPX3) has been found to be frequently repressed in many cancers due to promoter hypermethylation and is known as a possible tumor suppressor gene...
  89. Chien C, Huang T, Tai S, Chang N, Wang H, Wang L, et al. Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss. Kaohsiung J Med Sci. 2017;33:359-364 pubmed publisher
    The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis...
  90. Tanaka H, Shimazawa M, Takata M, Kaneko H, Tsuruma K, Ikeda T, et al. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. J Neurol. 2013;260:1782-97 pubmed publisher
    ..spots and identified two candidate proteins-inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and glutathione peroxidase 3 (Gpx3)...
  91. Jabłońska E, Reszka E. Selenium and Epigenetics in Cancer: Focus on DNA Methylation. Adv Cancer Res. 2017;136:193-234 pubmed publisher
    ..Se affects methylation of specific tumor suppressor genes, possibly in a sex-dependent manner; and cancer phenotype is often characterized by altered methylation of selenoprotein-encoding genes, mainly glutathione peroxidase 3.
  92. Lee W, Chen Y, Chu Y, Chien D. Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis. Clin Chim Acta. 2019;489:177-182 pubmed publisher
    ..0001), regardless of gender or age difference. These findings suggest that the decrease in GPx-3 bioactivity observed in the septic patients was resulted from the significant sepsis-related decline of GPx-3 protein concentrations. ..