GPX2

Summary

Gene Symbol: GPX2
Description: glutathione peroxidase 2
Alias: GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2, glutathione peroxidase 2, gastrointestinal glutathione peroxidase, glutathione peroxidase 2 (gastrointestinal), glutathione peroxidase-related protein 2
Species: human
Products:     GPX2

Top Publications

  1. Brigelius Flohe R, Kipp A. Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis. Ann N Y Acad Sci. 2012;1259:19-25 pubmed publisher
    Mammalian glutathione peroxidases (GPxs) are reviewed with emphasis on the role of the gastrointestinal GPx2 in tumorigenesis. GPx2 ranks high in the hierarchy of selenoproteins, corroborating its importance...
  2. Hakenewerth A, Millikan R, Rusyn I, Herring A, North K, Barnholtz Sloan J, et al. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2438-49 pubmed publisher
    ..Previously unreported associations of SNPs in ALDH2, CYP2E1, GPX2, SOD1, and SOD2 with SCCHN and subsite tumors provide evidence that alterations in alcohol and oxidative stress ..
  3. Tan W, Peh H, Liao W, Pang C, Chan T, Lau S, et al. Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide. J Nat Prod. 2016;79:1308-15 pubmed publisher
    ..Taken together, these findings strongly support a therapeutic potential for andrographolide in preventing lung inflammation caused by NTHi in cigarette smokers. ..
  4. Na H, Kim M, Chang S, Kim S, Park J, Chung M, et al. Tobacco smoking-response genes in blood and buccal cells. Toxicol Lett. 2015;232:429-37 pubmed publisher
    ..high levels of urinary MDA and down-regulation of expressions of antioxidant related genes including TPO, MPO, GPX2, PTGR1, and NUDT1 as compared to nonsmokers (ps<0.05)...
  5. Peng K, Tsai M, Lee C, Chiang Y, Chen P, Chen C, et al. Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis. PLoS ONE. 2018;13:e0202501 pubmed publisher
    ..Only a few antioxidant enzymes including SOD2 and GPx2 showed down-regulation...
  6. Yu X, Li S, Yang D, Qiu L, Wu Y, Wang D, et al. A novel strain of Lactobacillus mucosae isolated from a Gaotian villager improves in vitro and in vivo antioxidant as well as biological properties in D-galactose-induced aging mice. J Dairy Sci. 2016;99:903-914 pubmed publisher
    ..e., MT1A and MT1M in HT-29 and Caco-2) and those genes (i.e., MT1, MT2, GPx1, and GPx2) in the intestinal tract of the model mice...
  7. Doi K, Fujioka M, Sokuza Y, Ohnishi M, Gi M, Takeshita M, et al. Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis. In Vivo. 2017;31:187-197 pubmed
    ..Suppression of inflammation and oxidative stress, which had been triggered by DMH and promoted by DSS, was a primary mechanism by which EEP suppressed carcinogenesis. ..
  8. Nezzar H, Mbekeani J, Noblanc A, Chiambaretta F, Drevet J, Kocer A. Investigation of antioxidant systems in human meibomian gland and conjunctival tissues. Exp Eye Res. 2017;165:99-104 pubmed publisher
    ..In addition to the ubiquitous cytosolic GPx1 protein, there was significant expression of GPx2, GPx4 and GPx7. These isoforms are known to preferentially scavenge phospholipid-hydroperoxide compounds...
  9. Zavyalova E, Kopylov A. Multiple inhibitory kinetics reveal an allosteric interplay among thrombin functional sites. Thromb Res. 2015;135:212-6 pubmed publisher
    ..Improved turbidimetric assay is also applicable for studying the fibrin association inhibitors. Hence, GPRP-peptide was characterized kinetically for the first time...

More Information

Publications136 found, 100 shown here

  1. Marhfour I, Jonas J, Marchandise J, Lefevre A, Rahier J, Sempoux C, et al. Endoplasmic reticulum accumulation of Kir6.2 without activation of ER stress response in islet cells from adult Sur1 knockout mice. Cell Tissue Res. 2010;340:335-46 pubmed publisher
    ..However, mRNA levels of the antioxidant enzymes Sod1, Sod2, Gpx2 and catalase were significantly up-regulated in Sur1 ( -/- ) islets. Sequestration of Kir6...
  2. Magnusson P, Dziendzikowska K, Oczkowski M, Øvrevik J, Eide D, Brunborg G, et al. Lung effects of 7- and 28-day inhalation exposure of rats to emissions from 1st and 2nd generation biodiesel fuels with and without particle filter - The FuelHealth project. Environ Toxicol Pharmacol. 2019;67:8-20 pubmed publisher
    ..Exhaust filtration induced higher expression of redox genes (Cat, Gpx2) and the chemokine gene Cxcl7 compared to non-filtered exhaust...
  3. Hijazi A, Guan H, Cernea M, Yang K. Prenatal exposure to bisphenol A disrupts mouse fetal lung development. FASEB J. 2015;29:4968-77 pubmed publisher
    ..Taken together, these findings demonstrate that BPA disrupts fetal lung maturation, thus suggesting a fetal origin for BPA-induced lung diseases. ..
  4. Yang M, Luna L, Sørbø J, Alseth I, Johansen R, Backe P, et al. Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. Free Radic Biol Med. 2014;77:41-8 pubmed publisher
    ..Furthermore, expression of p21 and the antioxidant genes GPX2 and HO-1 was reduced in hOXR1-depleted cells...
  5. Herlan L, Schulz A, Schulte L, Schulz H, Hübner N, Kreutz R. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Clin Exp Pharmacol Physiol. 2015;42:1051-8 pubmed publisher
    ..Seven genes including Abcg5, Ab1-233, Efcab11, Fntb, Gpx2, Lrrn3, and Rtn1 were assigned on RNO6 and their differential expression was confirmed...
  6. Kodlekere P, Andrew Lyon L. Microgel core/shell architectures as targeted agents for fibrinolysis. Biomater Sci. 2018;6:2054-2058 pubmed publisher
    ..Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots...
  7. Wall S, Wood R, Dunigan K, Li Q, Li R, Rogers L, et al. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019;2019:7945983 pubmed publisher
    ..GCL) catalytic (Gclc) and modifier (Gclm) mRNA levels, total GSH levels, total GSH peroxidase (GPx) activity, and Gpx2 expression were determined in lung homogenates...
  8. Goodla L, Manubolu M, Pathakoti K, Jayakumar T, Sheu J, Fraker M, et al. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..pattern analyses revealed that significant alterations in superoxide dismutase (SOD1), glutathione peroxidase (GPx2, GPx3), and catalase (CAT) occurred in rats that were exposed to CCl4 and restored post EEAB treatment...
  9. Jo E, Youn C, Jun Y, Cho S. The protective role of ferulic acid against cisplatin-induced ototoxicity. Int J Pediatr Otorhinolaryngol. 2019;120:30-35 pubmed publisher
    ..the mRNA levels of antioxidant enzymes including glutamate-cysteine ligase catalytic subunit (Gclc), glutathione peroxidase 2 (Gpx2), catalase, and superoxide dismutase 2 (SOD2)...
  10. Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley R, et al. Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P. Sci Rep. 2017;7:4391 pubmed publisher
    ..SELENOP levels increased strongly in response to G418, whereas expression of the glutathione peroxidases GPX1 and GPX2 was marginally affected...
  11. Soeur J, Eilstein J, Léreaux G, Jones C, Marrot L. Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis. Free Radic Biol Med. 2015;78:213-23 pubmed publisher
    ..Together, these complementary experiments demonstrated the beneficial effects of RSV on skin, beyond its direct antioxidant properties, by upregulation of a cutaneous endogenous antioxidant pathway. ..
  12. Usarek E, Graboń W, Kaźmierczak B, Barańczyk Kuźma A. Targeting the expression of glutathione- and sulfate-dependent detoxification enzymes in HepG2 cells by oxygen in minimal and amino acid enriched medium. Exp Mol Pathol. 2016;100:82-6 pubmed publisher
    ..The result indicated that the expression of glutathione-dependent enzymes (GSTA, M, P, and GPX2) was sensitive to oxygen and medium type...
  13. Tindell R, Wall S, Li Q, Li R, Dunigan K, Wood R, et al. Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition. Redox Biol. 2018;19:331-338 pubmed publisher
    ..5 μM AFN. TXNRD1 and GPX2 protein expression and enzymatic activity were significantly greater upon Se supplementation (p < 0.05)...
  14. Zhao J, Xu S, Song F, Nian L, Zhou X, Wang S. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine-induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase. IUBMB Life. 2014;66:711-22 pubmed publisher
  15. Gräber T, Kluge H, Granica S, Horn G, Kalbitz J, Brandsch C, et al. Agrimonia procera exerts antimicrobial effects, modulates the expression of defensins and cytokines in colonocytes and increases the immune response in lipopolysaccharide-challenged piglets. BMC Vet Res. 2018;14:346 pubmed publisher
    ..coli strains. Stimulation of Caco-2 cells with TNFα resulted in elevated mRNA expression of CXCL1, IL-8 and GPX2. After pretreatment of cells with AP, stimulation of Caco-2 cells with TNFα still resulted in elevated mRNA ..
  16. Ismail M, Al Naqeep G, Chan K. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radic Biol Med. 2010;48:664-72 pubmed publisher
    ..treatment with TQRF and TQ caused the up-regulation of the superoxide dismutase 1 (SOD1), catalase, and glutathione peroxidase 2 (GPX) genes compared to untreated rats (P<0.05)...
  17. Hughes D, Kunická T, Schomburg L, Liska V, Swan N, Soucek P. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Nutrients. 2018;10: pubmed publisher
    ..i>GPX2 and TXNRD3 showed a higher expression and GPX3, SELENOP, SELENOS, and SEPHS2 ..
  18. Liu K, Jin M, Xiao L, Liu H, Wei S. Distinct prognostic values of mRNA expression of glutathione peroxidases in non-small cell lung cancer. Cancer Manag Res. 2018;10:2997-3005 pubmed publisher
    ..High expression of GPx2 mRNA was correlated with worse OS for all NSCLC patients...
  19. Sayed R, Khalil W, Salem H, Kenawy S, El Sayeh B. Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide. Nutr Res. 2014;34:982-9 pubmed publisher
    ..The GalN/LPS treatment increased the expression of superoxide dismutase-1, glutathione peroxidase 2, catalase, and heme oxygenase-1 genes...
  20. Navrot N, Skjoldager N, Bunkenborg J, Svensson B, Hägglund P. A redox-dependent dimerization switch regulates activity and tolerance for reactive oxygen species of barley seed glutathione peroxidase. Plant Physiol Biochem. 2015;90:58-63 pubmed publisher
    Monomeric and dimeric forms of recombinant barley (Hordeum vulgare subsp. vulgare) glutathione peroxidase 2 (HvGpx2) are demonstrated to display distinctly different functional properties in vitro...
  21. Engelken J, Espadas G, Mancuso F, Bonet N, Scherr A, Jímenez Álvarez V, et al. Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver. Mol Biol Evol. 2016;33:738-54 pubmed publisher
    ..Six of these exceeded the false discovery rate cutoff and were related to essential trace elements: 1) one pQTL for GPX2 (rs10133290); 2) two previously described eQTLs for HFE (rs12346) and SELO (rs4838862) expression; and 3) three ..
  22. Zhuang Y, Yang F, Xu D, Chen H, Zhang H, Liu G. Spliced leader-based analyses reveal the effects of polycyclic aromatic hydrocarbons on gene expression in the copepod Pseudodiaptomus poplesia. Aquat Toxicol. 2017;183:114-126 pubmed publisher
    ..poplesia. The transcriptional responses of GST-T, GPX2 and GPX4 upon pyrene exposure were minimal. Our results reveal the different sensitivity of P...
  23. Curti V, Di Lorenzo A, Rossi D, Martino E, Capelli E, Collina S, et al. Enantioselective Modulatory Effects of Naringenin  Enantiomers on the Expression Levels of miR-17-3p  Involved in Endogenous Antioxidant Defenses. Nutrients. 2017;9: pubmed publisher
    ..of target mRNAs coding for two antioxidant enzymes, manganese-dependent superoxide dismutase (MnSOD) and glutathione peroxidase 2 (GPx2), while expression levels of miR-25-5p were not in agreement with its target mRNAs, coding for two ..
  24. Sun Y, Zhang J, Song W, Shan A. Vitamin E alleviates phoxim-induced toxic effects on intestinal oxidative stress, barrier function, and morphological changes in rats. Environ Sci Pollut Res Int. 2018;25:26682-26692 pubmed publisher
    ..05). The mRNA expression levels of oxidative stress-related genes (Nrf2 and GPx2) were decreased. The mRNA expression of SOD was significantly increased...
  25. Xu Z, Zhang Y, Ding J, Hu W, Tan C, Wang M, et al. miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells. Mol Ther Nucleic Acids. 2018;13:64-77 pubmed publisher
    ..e., manganese superoxide dismutase (MnSOD), glutathione peroxidase 2 (Gpx2), and thioredoxin reductase 2 (TrxR2)...
  26. Kunwar A, Haston C. Basal levels of glutathione peroxidase correlate with onset of radiation induced lung disease in inbred mouse strains. Am J Physiol Lung Cell Mol Physiol. 2014;307:L597-604 pubmed publisher
    ..Basal GPx activity (r = 0.73, P = 0.04) in the lung and the pulmonary expression of GPx2 (r = 0.94, P = 0...
  27. Li X, Xing M, Chen M, Zhao J, Fan R, Zhao X, et al. Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf. 2017;139:447-453 pubmed publisher
    ..The levels of Se and Pb in chicken serum, mRNA levels of 24 selenoproteins (GPX1, GPX2, GPX3, GPX4, Dio1, Dio2, Dio3, Txnrd1, Txnrd2, Txnrd3, SELS, SPS2, SELK, SELW1, SEP15, SEPX1, SELT, SELI, SELO, ..
  28. Gao Q, Esworthy R, Kim B, Synold T, Smith D, Chu F. Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase. Inflamm Bowel Dis. 2010;16:2043-54 pubmed publisher
    ..GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) background, have mild ileocolitis on a conventional chow...
  29. Danielli N, Trevisan R, Mello D, Fischer K, Deconto V, da Silva Acosta D, et al. Upregulating Nrf2-dependent antioxidant defenses in Pacific oysters Crassostrea gigas: Investigating the Nrf2/Keap1 pathway in bivalves. Comp Biochem Physiol C Toxicol Pharmacol. 2017;195:16-26 pubmed publisher
    ..The relative mRNA levels coding glutamate-cysteine ligase, GR, GPx2 and GSTpi were clearly induced by curcumin treatment (30?M, 24h)...
  30. Reszka E, Wieczorek E, Jablonska E, Janasik B, Fendler W, Wasowicz W. Association between plasma selenium level and NRF2 target genes expression in humans. J Trace Elem Med Biol. 2015;30:102-6 pubmed publisher
    ..NRF2, KEAP2, CAT, EPHX1, GCLC, GCLM, GPX2, GSR, GSTA1, GSTM1, GSTP1, GSTT1, HMOX1, NQO1, PRDX1, SOD1, SOD2, TXNRD1 transcript levels in peripheral blood ..
  31. Kunwar A, Verma P, Bhilwade H, Iwaoka M, Priyadarsini K. Dihydroxyselenolane (DHS) supplementation improves survival following whole-body irradiation (WBI) by suppressing tissue-specific inflammatory responses. Mutat Res Genet Toxicol Environ Mutagen. 2016;807:33-46 pubmed publisher
    ..DHS treatment, despite inducing expression of glutathione peroxidases (GPx1, GPx2, and GPx4) in spleen and intestine, did not protect against radiation-induced acute (10-day) haematopoietic and ..
  32. Jiang X, Cao C, Li Z, Li W, Zhang C, Lin J, et al. Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system. J Inorg Biochem. 2017;169:13-22 pubmed publisher
    ..Selenoprotein P (Sepp1), Selenoprotein O (Selo), Selenoprotein 15 (Sel15), Selenoprotein N (Seln), Glutathione peroxidase 2 (Gpx2) and Selenoprotein P 2 (Sepp2) take more necessary function in the chicken CNS...
  33. Taranu I, Braicu C, Marin D, Pistol G, Motiu M, Balacescu L, et al. Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression. Toxicol Lett. 2015;232:310-25 pubmed publisher
    ..An up-regulation of glutathione peroxidase enzymes (GPx6, GPx2, GPx1) was also observed...
  34. Bajak E, Fabbri M, Ponti J, Gioria S, Ojea Jiménez I, Collotta A, et al. Changes in Caco-2 cells transcriptome profiles upon exposure to gold nanoparticles. Toxicol Lett. 2015;233:187-99 pubmed publisher
    ..Some Nrf2 responsive genes (several metallothioneins, HMOX, G6PD, OSGIN1 and GPX2) were highly up regulated. Members of the selenoproteins were also differentially expressed...
  35. Esworthy R, Kim B, Larson G, Yip M, Smith D, Li M, et al. Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2. Inflamm Bowel Dis. 2011;17:1373-86 pubmed publisher
    Genetic background has a profound effect on inflammatory bowel disease. The Gpx1 and Gpx2 double knockout (GPX1/2-DKO) mice on a mixed C57BL/6 (B6) and 129S1/SvimJ (129) background exhibit spontaneous ileocolitis...
  36. Khoso P, Yang Z, Liu C, Li S. Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency. Cell Stress Chaperones. 2015;20:967-78 pubmed publisher
    ..showed that the mRNA expression levels of selenoproteins, such as Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, GPx1, GPx2, GPx3 GPx4, Sepp1, Selo, Sel-15, Sepx1, Sels, Seli, Selu, Selh, and SPS2, were significantly lower (P < 0...
  37. Zhang J, Xu B, Huang X, Gao Y, Chen Y, Shan A. Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks. Biol Trace Elem Res. 2016;171:201-7 pubmed publisher
    ..SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0...
  38. Steven Esworthy R, Kim B, Wang Y, Gao Q, Doroshow J, Leto T, et al. The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene. Free Radic Biol Med. 2013;65:1273-1283 pubmed publisher
    ..Gpx-deficiency-associated colitis 1) locus, which influences the severity of spontaneous colitis in Gpx1- and Gpx2-double-knockout (Gpx1/2-DKO) mice...
  39. Lessard M, Savard C, Deschene K, Lauzon K, Pinilla V, Gagnon C, et al. Impact of deoxynivalenol (DON) contaminated feed on intestinal integrity and immune response in swine. Food Chem Toxicol. 2015;80:7-16 pubmed publisher
    ..also revealed that expression of two chemokines (IL-8, CXCL10), interferon-γ, and major antioxidant glutathione peroxidase 2 (GPX-2) were up-regulated whereas expression of genes encoding enzymatic antioxidants including GPX-3, ..
  40. Ramos J, Matamoros M, Naya L, James E, Rouhier N, Sato S, et al. The glutathione peroxidase gene family of Lotus japonicus: characterization of genomic clones, expression analyses and immunolocalization in legumes. New Phytol. 2009;181:103-114 pubmed publisher
    ..of the six genes, and cadmium caused up-regulation of GPX3, GPX4 and GPX5 after 1 h and down-regulation of GPX1, GPX2, GPX4 and GPX6 after 3-24 h...
  41. Youn C, Jo E, Sim J, Cho S. Peanut sprout extract attenuates cisplatin-induced ototoxicity by induction of the Akt/Nrf2-mediated redox pathway. Int J Pediatr Otorhinolaryngol. 2017;92:61-66 pubmed publisher
    ..Real-time PCR analyses were performed to investigate the mRNA levels of antioxidant enzymes including NQO1, HO-1, GPx2, Gclc, and catalase...
  42. Liang Y, Harris F, Jones D, Brown L. Alcohol induces mitochondrial redox imbalance in alveolar macrophages. Free Radic Biol Med. 2013;65:1427-1434 pubmed publisher
    ..and Prdx5 plus the mitochondrial thiol-disulfide proteins glutaredoxin 2, glutathione reductase, and glutathione peroxidase 2. Thus, the mitochondrial thioredoxin circuit was highly oxidized by ethanol, thereby compromising the ..
  43. Ano S, Panariti A, Allard B, O Sullivan M, McGovern T, Hamamoto Y, et al. Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice. Free Radic Biol Med. 2017;102:1-15 pubmed publisher
    ..Lung GSH and mRNA for Nrf2-dependent phase II enzymes (NQO-1 and GPX2) were significantly lower in Nrf2-deficient than wild-type mice after Cl2 exposure...
  44. Tahmasbpour E, Ghanei M, Qazvini A, Vahedi E, Panahi Y. Gene expression profile of oxidative stress and antioxidant defense in lung tissue of patients exposed to sulfur mustard. Mutat Res Genet Toxicol Environ Mutagen. 2016;800-801:12-21 pubmed publisher
    ..the most upregulated genes were OS responsive-1 (OXSR1), forkhead box M1 (FOXM1), and glutathione peroxidase-2 (GPX2), while metallothionein-3 (MT3) and glutathione reductase (GSR) were the most downregulated genes...
  45. Gao H, Liu C, Song S, Fu J. Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken. Biol Trace Elem Res. 2016;172:234-41 pubmed publisher
    ..In detail, Se could alleviate the downtrend of the expression of Gpx1, Gpx2, Gpx4, Txnrd2, Txnrd3, Dio1, Dio2, Seli, Selu, Sepx1, Selk, Selw, Selo, Selm, Sep15, Sepnn1, Sels, and Selt induced ..
  46. Lan X, Xing J, Gao H, Li S, Quan L, Jiang Y, et al. Decreased Expression of Selenoproteins as a Poor Prognosticator of Gastric Cancer in Humans. Biol Trace Elem Res. 2017;178:22-28 pubmed publisher
    ..The expression of 25 selenoprotein genes (Dio1, Dio2, Dio3, Gpx1, Gpx2, Gpx3, Gpx4, Gpx6, SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelS, SelT, SelV, SelW, SelX, Sel15, Sps2, TR1, TR2, ..
  47. Lennicke C, Rahn J, Wickenhauser C, Lichtenfels R, Müller A, Wessjohann L, et al. Loss of epithelium-specific GPx2 results in aberrant cell fate decisions during intestinal differentiation. Oncotarget. 2018;9:539-552 pubmed publisher
    The selenoprotein glutathione peroxidase 2 (GPx2) is expressed in the epithelium of the gastrointestinal tract, where it is thought to be involved in maintaining mucosal homeostasis...
  48. Liu M, Gao R, Meng Q, Zhang Y, Bi C, Shan A. Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats. PLoS ONE. 2014;9:e106412 pubmed publisher
    ..Decreased expression of jejunal interleukin-8 (IL-8) and increased expression of gastrointestinal glutathione peroxidase (GPx2) mRNA were detected in weaned offspring, indicating long-term damage caused by maternal ZEN...
  49. Dannenmann B, Lehle S, Hildebrand D, Kübler A, Grondona P, Schmid V, et al. High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells. Stem Cell Reports. 2015;4:886-98 pubmed publisher
    ..Thus, iPSCs ensure genomic integrity through enhanced apoptosis induction and increased antioxidant defense, contributing to protection against DNA damage. ..
  50. Bouch S, O Reilly M, de Haan J, Harding R, Sozo F. Does lack of glutathione peroxidase 1 gene expression exacerbate lung injury induced by neonatal hyperoxia in mice?. Am J Physiol Lung Cell Mol Physiol. 2017;313:L115-L125 pubmed publisher
    ..i>GPx1 expression was significantly decreased in GPx1-/- mice; GPx2-4 and catalase expression was increased in GPx1-/-Hyp mice compared with other groups...
  51. Chaurasia R, Balakrishnan S, Kunwar A, Yadav U, Bhat N, Anjaria K, et al. Cyto-genotoxicity assessment of potential radioprotector, 3,3'-diselenodipropionic acid (DSePA) in Chinese Hamster Ovary (CHO) cells and human peripheral blood lymphocytes. Mutat Res Genet Toxicol Environ Mutagen. 2014;774:8-16 pubmed publisher
    ..Further, it was seen to augment the mRNA expressions of GPx2 significantly and GPx4 marginally without causing much change in the total GPx activity after radiation exposure...
  52. Nuoc T, Kim S, Ahn S, Lee J, Park B, Lee T. The analysis of antioxidant expression during muscle atrophy induced by hindlimb suspension in mice. J Physiol Sci. 2017;67:121-129 pubmed publisher
    ..Additionally, HLS mice demonstrated a decrease in Prdx5 and MnSOD, but an increase in GPX2 and GPX3 in both mRNA and protein levels...
  53. Gordeeva A, Temnov A, Charnagalov A, Sharapov M, Fesenko E, Novoselov V. Protective Effect of Peroxiredoxin 6 in Ischemia/Reperfusion-Induced Damage of Small Intestine. Dig Dis Sci. 2015;60:3610-9 pubmed publisher
    ..analysis of genes coding for major antioxidant enzymes demonstrated a significant activation of SOD 1, SOD 3, Prx6, GPx2, GPx7 expression during I/R-induced damage of the small intestine...
  54. Chen W, Li Y, Chen P, Wu M, Wang L, Zhang H, et al. In vitro fibrinolysis and antithrombosis characterizations of novel recombinant microplasminogen with RGD and GPRP peptides. J Thromb Thrombolysis. 2016;42:118-26 pubmed publisher
    ..we constructed two μPlg variants containing tripeptide Arg-Gly-Asp (RGD) and tetrapeptide Gly-Pro-Arg-Pro (GPRP) by site-directed mutagenesis...
  55. Wang X, Bao R, Fu J. The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue. Biol Trace Elem Res. 2018;181:331-339 pubmed publisher
    ..B (NF-?B), tumor necrosis factor-? (TNF-?), and cyclooxygenase-2 (COX-2)) and 25 selenoprotein genes (Gpx1, Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, SPS2, Sepp1, SelPb, Sep15, Selh, Seli, Selm, Selo, Sels, ..
  56. Ferretti E, Tremblay E, Thibault M, Grynspan D, Burghardt K, Bettolli M, et al. The nitric oxide synthase 2 pathway is targeted by both pro- and anti-inflammatory treatments in the immature human intestine. Nitric Oxide. 2017;66:53-61 pubmed publisher
    ..of tight junction components such as CLDN1, CLDN2, CLDN7 and OCN and of antioxidant markers such as DUOX2, GPX2, SOD2 were also found to be differentially modulated by EGF and INDO...
  57. Wang Y, Guo Y, Chen H, Wei H, Wan C. Potential of Lactobacillus plantarum ZDY2013 and Bifidobacterium bifidum WBIN03 in relieving colitis by gut microbiota, immune, and anti-oxidative stress. Can J Microbiol. 2018;64:327-337 pubmed publisher
    ..g., TNF-?) and upregulating antioxidant factors (e.g., SOD1, SOD2, GPX2) at the transcriptional level...
  58. Cao J, Tang L, Zhang J, Zhan Y, Yang X, Ge C. [Construction a lentiviral vector for RNA interference of glutathione peroxidase 2 gene and its effect on HepG2 cell apoptosis]. Nan Fang Yi Ke Da Xue Xue Bao. 2015;35:832-7 pubmed
    To construct a RNA interference lentiviral vector for human glutathione peroxidase 2 (GPX2) gene and observe the effect of GPX2 knockdown on cell apoptosis...
  59. Badia E, Morena M, Lauret C, Boulahtouf A, Boulle N, Cavaillès V, et al. Effect of tamoxifen and fulvestrant long-term treatments on ROS production and (pro/anti)-oxidant enzymes mRNA levels in a MCF-7-derived breast cancer cell line. Breast Cancer. 2016;23:692-700 pubmed publisher
    ..Short-term estradiol treatment showed a hormone sensitivity of Nox2, GPx1, GPx2 and SOD1 mRNA levels...
  60. Wang Q, Huang J, Zhang H, LEI X, Du Z, Xiao C, et al. Selenium Deficiency-Induced Apoptosis of Chick Embryonic Vascular Smooth Muscle Cells and Correlations with 25 Selenoproteins. Biol Trace Elem Res. 2017;176:407-415 pubmed publisher
    ..levels of selenium addition, Gpx1, Gpx3, Gpx4, SepW1, and Sep15 mRNAs were all highly expressed in VSMCs, whereas Gpx2, Dio1, SepN1, SelO, and SelPb were at lower levels...
  61. Gladyshev V, Arnér E, Berry M, Brigelius Flohe R, Bruford E, Burk R, et al. Selenoprotein Gene Nomenclature. J Biol Chem. 2016;291:24036-24040 pubmed
    ..functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (..
  62. Förster N, Mewis I, Glatt H, Haack M, Brigelius Flohe R, Schreiner M, et al. Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food Funct. 2016;7:4660-4674 pubmed
    ..Reporter gene assays revealed a significant increase in the ARE-dependent promoter activity of NQO1 and GPx2 indicating an activation of the Nrf2 pathway by M. oleifera glucosinolates...
  63. Cao L, Tang J, Li Q, Xu J, Jia G, Liu G, et al. Expression of Selenoprotein Genes Is Affected by Heat Stress in IPEC-J2 Cells. Biol Trace Elem Res. 2016;172:354-60 pubmed publisher
    ..05 or as indicated) six selenoprotein genes (Gpx2, Gpx6, Txnrd1, Selh, Selm, Selx) and three inflammation-related genes (Ifn-β, Mcp-1, Tnf-α) in the cells...
  64. Nejad Moghaddam A, Ajdary S, Tahmasbpour E, Rad F, Panahi Y, Ghanei M. Immunomodulatory Properties of Mesenchymal Stem Cells Can Mitigate Oxidative Stress and Inflammation Process in Human Mustard Lung. Biochem Genet. 2016;54:769-783 pubmed
    ..of several oxidative stress- (metallothionein 3, glutathione reductase, oxidative stress responsive 1, glutathione peroxidase 2, lacto peroxidase, forkhead box M1) and inflammation-related genes (matrix metallopeptidase 2, matrix ..
  65. Wang S, Lai K, Li C, Chiang C, Yu G, Sakamoto N, et al. The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities. PLoS ONE. 2017;12:e0164281 pubmed publisher
    ..Surprisingly, the DNA qPCR arrays and western blotting showed that the damage-related genes GPX2, MRE11, phospho-ATM, and OGG1 were significantly up-regulated in LVL cells but inversely down-regulated or ..
  66. Tang H, Li H, Li Y, You Y, Guan Y, Zhang S, et al. Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-?B and Nrf2 signaling pathways. J Ethnopharmacol. 2018;217:118-125 pubmed publisher
    ..IFN-?), and up-regulate IL-10 as well as superoxide-dimutase-1 (SOD1), glutathione reductase (GSR) and Glutathione peroxidase 2 (GPX2) mRNA in the liver tissues after Con A injection...
  67. Cammarota F, Fiscardi F, Esposito T, De Vita G, Salvatore M, Laukkanen M. Clinical relevance of thyroid cell models in redox research. Cancer Cell Int. 2015;15:113 pubmed publisher
    ..thyroid PC Cl3, PC PTC1, PC E1A, or FRLT5 cell models can be used to study NOX2, NOX4, SOD2, SOD3, CATALASE, GPX1, GPX2, GPX5, PRDX2, and PRDX3 gene expression and function...
  68. Juszczuk Kubiak E, Bujko K, Cymer M, Wicińska K, Gabryszuk M, Pierzchała M. Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs. Biol Trace Elem Res. 2016;172:336-45 pubmed publisher
    ..Significant differences were found in the expression of GPX1, GPX2, SEPM, SEPW1, SEP15, SEPGS2, and TXNRD1 in the liver, and GPX1, SEPP1, SEPN1, SEPW1, SEP15, and MSRB1 in the LD ..
  69. Fan R, Yao H, Zhao X, Cao C, Yang T, Luan Y, et al. Gene expression of selenoproteins can be regulated by selenoprotein K silencing in chicken myoblasts. Biometals. 2016;29:679-89 pubmed publisher
    ..pattern of mRNA expression after siRNA treatment in three groups were found similar: one group including Gpx1, Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Txnrd3, Sepw1, Selh, Sepp1, Selo and Sepx1, another group including Sepn1, Sels, Selt, ..
  70. Liu S, Kawamoto T, Morita O, Yoshinari K, Honda H. Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. Toxicol Appl Pharmacol. 2017;318:79-87 pubmed publisher
    ..g., Acot1 and Abcc3) and 13 genes for hypertrophic hepatocarcinogenesis (e.g., Asns and Gpx2) were selected. The predictive models built using these genes were 94.8% and 82.7% accurate, respectively...
  71. Solleti S, Bhattacharya S, Ahmad A, Wang Q, Mereness J, Rangasamy T, et al. MicroRNA expression profiling defines the impact of electronic cigarettes on human airway epithelial cells. Sci Rep. 2017;7:1081 pubmed publisher
    ..of NHBE to any eCig liquid resulted in the induction of oxidative stress-response genes including GCLM, GCLC, GPX2, NQO1 and HO-1...
  72. Soo H, Chung F, Lim K, Yap V, Bradshaw T, Hii L, et al. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PLoS ONE. 2017;12:e0170551 pubmed publisher
    ..tumor suppressor genes EGR1, HUWE1 and SMG1 were significantly up-regulated while oncogenes such as MYB1, CCNB1 and GPX2 were down-regulated following treatment with Cud C...
  73. Capkin E, Ozcelep T, Kayis S, Altinok I. Antimicrobial agents, triclosan, chloroxylenol, methylisothiazolinone and borax, used in cleaning had genotoxic and histopathologic effects on rainbow trout. Chemosphere. 2017;182:720-729 pubmed publisher
    ..Transcription of SOD, GPX1, GPX2, GSTA, HSP90BB, HSP90BA, CAT, and HSC70A genes were significantly regulated as a result of TRC, PCMX, MIT, and BRX ..
  74. Petersen C, Weis V, Nam K, Sousa J, Fingleton B, Goldenring J. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology. 2014;146:1727-38.e8 pubmed publisher
    ..To characterize SPEM in each model, gastric tissues were collected and levels of Cftr, Dmbt1, and Gpx2 mRNAs were measured...
  75. Martitz J, Becker N, Renko K, Stoedter M, Hybsier S, Schomburg L. Gene-specific regulation of hepatic selenoprotein expression by interleukin-6. Metallomics. 2015;7:1515-21 pubmed publisher
    ..peroxidase (GPX) expression were isozyme-specific; GPX1 remained unaffected, while transcript concentrations of GPX2 increased and those of GPX4 decreased...
  76. Connor E, Wall E, Bravo D, Evock Clover C, Elsasser T, Baldwin R, et al. Reducing gut effects from Cryptosporidium parvum infection in dairy calves through prophylactic glucagon-like peptide 2 therapy or feeding of an artificial sweetener. J Dairy Sci. 2017;100:3004-3018 pubmed publisher
    ..increased villus apoptosis and crypt cell proliferation, and increased intestinal mRNA expression of MARVELD2 and GPX2. However, calves in SUC and GLP2 had reduced diarrhea severity and fecal C...
  77. Choi J, Liu R, Kundu R, Sangiorgi F, Wu W, Maxson R, et al. Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. J Biol Chem. 2000;275:3693-8 pubmed
    ..Therefore, Tat appears to decrease GSH in vivo, at least partially, through modulation of GSH biosynthetic enzymes. ..
  78. Esworthy R, Binder S, Doroshow J, Chu F. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem. 2003;384:597-607 pubmed
    ..germ-free GPX-DKO mice developed severe acute colitis while their littermates with at least one wild-type Gpx1 or Gpx2 gene remained virtually symptom-free. Microflora also affected Gpx2 gene expression...
  79. Price T, Ercal N, Nakaoke R, Banks W. HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Brain Res. 2005;1045:57-63 pubmed
    ..The ratio of GSH/GSSG, a widely accepted indicator of oxidative stress, was also significantly decreased. These studies show that both of these viral proteins can induce oxidative stress in immortalized BBB endothelial cells. ..
  80. Banning A, Kipp A, Schmitmeier S, Löwinger M, Florian S, Krehl S, et al. Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. Cancer Res. 2008;68:9746-53 pubmed publisher
    The selenoprotein gastrointestinal glutathione peroxidase 2 (GPx2) is up-regulated in a variety of cancer cells with thus far unknown consequences...
  81. Lee M, Park J. Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid. J Microbiol Biotechnol. 2009;19:1103-8 pubmed
    ..The results indicate that the up- and downregulated genes regulate HIV-1 replication and proliferation, and viral entry. ..
  82. Emmink B, Laoukili J, Kipp A, Koster J, Govaert K, Fatrai S, et al. GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. Cancer Res. 2014;74:6717-30 pubmed publisher
    ..Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures...
  83. Chu F, Esworthy R, Doroshow J, Grasberger H, Donkó A, Leto T, et al. Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium. Redox Biol. 2017;11:144-156 pubmed publisher
    Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1-/-GPx2-/- double knockout or DKO mice) develop very-early-onset (VEO) ileocolitis, suggesting that lack of defense against reactive oxygen species (ROS) ..
  84. Liu Q, Yang J, Cai J, Luan Y, Sattar H, Liu M, et al. Analysis of the Interactions Between Thioredoxin and 20 Selenoproteins in Chicken. Biol Trace Elem Res. 2017;179:304-317 pubmed publisher
    ..iodothyronine deiodinase 1 (Dio1), iodothyronine deiodinase 3 (Dio3), glutathione peroxidase 1 (Gpx1), glutathione peroxidase 2 (Gpx2), glutathione peroxidase 3 (Gpx3), glutathione peroxidase 4 (Gpx4), selenoprotein H (SelH), ..
  85. Kipp A. Selenium-Dependent Glutathione Peroxidases During Tumor Development. Adv Cancer Res. 2017;136:109-138 pubmed publisher
    ..Most Se-dependent GPxes are downregulated in tumor cells, while only GPx2 is considerably upregulated...
  86. Chu F, Doroshow J, Esworthy R. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. J Biol Chem. 1993;268:2571-6 pubmed
    ..In conclusion, we have demonstrated that GSHPx-GI is the fourth member in the selenium-dependent glutathione peroxidase family, in addition to GSHPx-1, GSHPx-P, and phospholipid hydroperoxide glutathione peroxidase (PHGPX). ..
  87. Opalenik S, Ding Q, Mallery S, Thompson J. Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. Arch Biochem Biophys. 1998;351:17-26 pubmed
  88. Komatsu H, Okayasu I, Mitomi H, Imai H, Nakagawa Y, Obata F. Immunohistochemical detection of human gastrointestinal glutathione peroxidase in normal tissues and cultured cells with novel mouse monoclonal antibodies. J Histochem Cytochem. 2001;49:759-66 pubmed
    This is the first report to describe the successful detection of human gastrointestinal glutathione peroxidase in normal tissues by Western blotting and immunohistochemical staining techniques...
  89. Kipp A, Banning A, Brigelius Flohe R. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. Biol Chem. 2007;388:1027-33 pubmed
    GPx2, formerly named gastrointestinal glutathione peroxidase, is highly expressed in the proliferative area of the intestinal crypt-to-villus axis and in Paneth cells...
  90. Naiki Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, et al. Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res. 2007;67:11353-8 pubmed
    ..DNA microarray analysis revealed that glutathione peroxidase 2 (Gpx2) was commonly up-regulated in the mammary carcinomas induced by the three different carcinogens, ..
  91. Peters U, Chatterjee N, Hayes R, Schoen R, Wang Y, Chanock S, et al. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2008;17:1144-54 pubmed publisher
    ..We genotyped 44 tagging single nucleotide polymorphisms (SNP) in six genes [glutathione peroxidase 1-4 (GPX1, GPX2, GPX3, and GPX4), selenoprotein P (SEPP1), and thioredoxin reductase 1 (TXNRD1)] to efficiently predict common ..
  92. Kipp A, Müller M, Göken E, Deubel S, Brigelius Flohe R. The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. Biochim Biophys Acta. 2012;1820:1588-96 pubmed publisher
    The glutathione peroxidase 2 (GPx2) is expressed at crypt bases of the intestinal epithelium and in tumour tissue. The GPx2 promoter is activated by the Wnt pathway, which might be the reason for the specific expression pattern of GPx2...