GPX1

Summary

Gene Symbol: GPX1
Description: glutathione peroxidase 1
Alias: GPXD, GSHPX1, glutathione peroxidase 1, GSHPx-1, cellular glutathione peroxidase
Species: human
Products:     GPX1

Top Publications

  1. Price T, Ercal N, Nakaoke R, Banks W. HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. Brain Res. 2005;1045:57-63 pubmed
    ..The ratio of GSH/GSSG, a widely accepted indicator of oxidative stress, was also significantly decreased. These studies show that both of these viral proteins can induce oxidative stress in immortalized BBB endothelial cells. ..
  2. Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, et al. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. Diabetes. 2004;53:2455-60 pubmed
    ..These results suggest that functional variants in the GPx-1 gene are associated with increased IMT of carotid arteries and risk of cardiovascular and peripheral vascular diseases in type 2 diabetic patients. ..
  3. Esworthy R, Ho Y, Chu F. The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch Biochem Biophys. 1997;340:59-63 pubmed
    Mitochondria have GPX and PHGPX activity. It has been an unsettled issue whether mitochondrial GPX is encoded by Gpx1. Unlike the Gpx4 gene which encodes PHGPX with alternative transcription and translation start sites determining the ..
  4. Jablonska E, Gromadzinska J, Reszka E, Wasowicz W, Sobala W, Szeszenia Dabrowska N, et al. Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans. Eur J Nutr. 2009;48:383-6 pubmed publisher
    b>Glutathione peroxidase 1 (GPx1) is an antioxidant selenoenzyme that protects the cells against reactive oxygen species. Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme...
  5. Hansen R, Krath B, Frederiksen K, Tjønneland A, Overvad K, Roswall N, et al. GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer. Mutat Res. 2009;664:13-9 pubmed publisher
    GPX1 encoding the enzyme glutathione peroxidase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures...
  6. Soerensen M, Christensen K, Stevnsner T, Christiansen L. The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Mech Ageing Dev. 2009;130:308-14 pubmed publisher
    ..The rs4880 and rs1050450 SNPs in the manganese superoxide dismutase (MnSOD) and glutathione peroxidase 1 (GPX1) genes, respectively, are associated with age-related diseases and appear to affect the activities ..
  7. Kodydkova J, Vavrova L, Zeman M, Jirak R, Macásek J, Stankova B, et al. Antioxidative enzymes and increased oxidative stress in depressive women. Clin Biochem. 2009;42:1368-74 pubmed publisher
    ..DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (..
  8. Udler M, Maia A, Cebrian A, Brown C, Greenberg D, Shah M, et al. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J Clin Oncol. 2007;25:3015-23 pubmed
    ..05) in 10 genes involved in oxidative damage repair (CAT, SOD1, SOD2, GPX1, GPX4, GSR, TXN, TXN2, TXNRD1, and TXNRD2) and survival in 4,470 women with breast cancer...
  9. Cox D, Tamimi R, Hunter D. Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study. BMC Cancer. 2006;6:217 pubmed
    ..87, 95% CI 1.09 - 3.19) is observed in individuals who carry both the Ala16Ala genotype of MnSOD and the Leu198Leu genotype of GPX-1. Polymorphisms in the GPX-1 and MnSOD genes are associated with an increased risk of breast cancer. ..

More Information

Publications83

  1. Ravn Haren G, Olsen A, Tjønneland A, Dragsted L, Nexø B, Wallin H, et al. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis. 2006;27:820-5 pubmed
    ..patients have been reported to have lower antioxidant enzyme activity than healthy controls and the polymorphism GPX1 Pro198Leu has been associated with risk of lung and breast cancer...
  2. Zhao H, Liang D, Grossman H, Wu X. Glutathione peroxidase 1 gene polymorphism and risk of recurrence in patients with superficial bladder cancer. Urology. 2005;66:769-74 pubmed
    To investigate the potential of genetic polymorphism (Pro198Leu) in the human glutathione peroxidase 1 (hGPX1) gene as a biologic marker predictive of bladder cancer recurrence...
  3. Knight J, Onay U, Wells S, Li H, Shi E, Andrulis I, et al. Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev. 2004;13:146-9 pubmed
    ..Three that have been identified are SOD2 Val-9Ala, GPX1 Pro198Leu, and the GPX1 GCG repeat (three alleles with four, five, or six repeats)...
  4. Blankenberg S, Rupprecht H, Bickel C, Torzewski M, Hafner G, Tiret L, et al. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med. 2003;349:1605-13 pubmed
    Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide dismutase have a central role in the control of reactive oxygen species...
  5. Hu Y, Diamond A. Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer Res. 2003;63:3347-51 pubmed
    A role for allelic variation within the gene for the antioxidant selenoprotein glutathione peroxidase 1 (GPx-1) in the risk or etiology of breast cancer was investigated...
  6. Méplan C, Dragsted L, Ravn Haren G, Tjønneland A, Vogel U, Hesketh J. Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk. PLoS ONE. 2013;8:e73316 pubmed publisher
    ..replacement therapy (HRT) use was genotyped for five functional single nucleotide polymorphisms (SNPs) in SEPP1, GPX1, GPX4 and the antioxidant enzyme SOD2 genes...
  7. Legault J, Carrier C, Petrov P, Renard P, Remacle J, Mirault M. Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells. Biochem Biophys Res Commun. 2000;272:416-22 pubmed
    ..The potential protection of mtDNA by glutathione peroxidase-1 (GPx1) was investigated in GPx1-proficient (GPx-2) and GPx1-deficient (Hygro-3) human breast T47D cell transfectants...
  8. Lubos E, Loscalzo J, Handy D. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011;15:1957-97 pubmed publisher
    ..This review discusses the role of GPx-1 in these diseases and speculates on potential future therapies to harness the beneficial effects of this ubiquitous antioxidant enzyme. ..
  9. Gouaze V, Andrieu Abadie N, Cuvillier O, Malagarie Cazenave S, Frisach M, Mirault M, et al. Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem. 2002;277:42867-74 pubmed
    ..place of ROS production in CD95-mediated apoptosis and the role of the antioxidant enzyme glutathione peroxidase-1 (GPx1)...
  10. Cebrian A, Pharoah P, Ahmed S, Smith P, Luccarini C, Luben R, et al. Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res. 2006;66:1225-33 pubmed
    ..We found no evidence for association of common variants in SOD1, SOD2, GPX1, GPX4, GSR, TXNRD1, and TXN2...
  11. Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, Balmes J, et al. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. Pharmacogenet Genomics. 2006;16:279-86 pubmed
    ..that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) and catalase...
  12. Raaschou Nielsen O, Sørensen M, Hansen R, Frederiksen K, Tjønneland A, Overvad K, et al. GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Cancer Lett. 2007;247:293-300 pubmed
    ..blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer...
  13. Bhatti P, Stewart P, Hutchinson A, Rothman N, Linet M, Inskip P, et al. Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2009;18:1841-8 pubmed publisher
    ..When the analyses were restricted to cases with glioblastoma multiforme, RAC2 rs2239774 and two highly correlated GPX1 polymorphisms (rs1050450 and rs18006688) were found to significantly modify the association with lead exposure (P &..
  14. Chen J, Cao Q, Qin C, Shao P, Wu Y, Wang M, et al. GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis. J Cancer Res Clin Oncol. 2011;137:1553-61 pubmed publisher
    ..These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance. ..
  15. Miller J, Thomson C, Williams S, van Havre N, Wilkins G, Morison I, et al. Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: a randomized controlled trial. Am J Clin Nutr. 2012;96:923-31 pubmed
    A genetic variant at codon 200 (Pro200Leu) of the gene encoding for glutathione peroxidase 1 (GPx1), a selenium-dependent enzyme, is associated with lower enzyme activity; however, the evidence is limited to in vitro and observational ..
  16. Vibet S, Goupille C, Bougnoux P, Steghens J, Gore J, Maheo K. Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response. Free Radic Biol Med. 2008;44:1483-91 pubmed publisher
    ..This was concomitant with a decreased cytosolic glutathione peroxidase (GPx1) activity, a crucial enzyme for protection against hydrogen and lipid peroxides, while major antioxidant enzyme ..
  17. Yang P, Bamlet W, Ebbert J, Taylor W, de Andrade M. Glutathione pathway genes and lung cancer risk in young and old populations. Carcinogenesis. 2004;25:1935-44 pubmed
    ..Using PCR amplification of genomic DNA, polymorphic markers for gammaGCS, GPX1, GSTP1 (I105V and A114V), GSTM1 and GSTT1 were genotyped...
  18. Forsberg L, de Faire U, Morgenstern R. Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1. Hum Mutat. 1999;13:294-300 pubmed
    ..we could verify one, an amino acid substitution Pro-Leu at amino acid position 197 (P197L), in the glutathione peroxidase 1 gene. The corresponding allele frequencies were approximately 70/30%...
  19. Arsova Sarafinovska Z, Matevska N, Eken A, Petrovski D, Banev S, Dzikova S, et al. Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk. Int Urol Nephrol. 2009;41:63-70 pubmed publisher
    b>Glutathione peroxidase 1 (GPX1) is a ubiquitously expressed selenium-dependent enzyme that protects cells against oxidative damage by reducing hydrogen peroxide and a wide range of organic peroxides...
  20. Agrawal L, Louboutin J, Reyes B, van Bockstaele E, Strayer D. Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis. Gene Ther. 2006;13:1645-56 pubmed
    ..ROS-mediated injury by antioxidant enzymes such as Cu/Zn-superoxide dismutase (SOD1) and/or glutathione peroxidase (GPx1). Both enzymes detoxify oxygen free radicals...
  21. Tang H, Dong X, Day R, Hassan M, Li D. Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. Carcinogenesis. 2010;31:607-13 pubmed publisher
    ..These data suggest that genetic variations in antioxidant defenses modify the risk of pancreatic cancer in diabetics or individuals with a low dietary vitamin E intake. ..
  22. Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, et al. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. Cancer Epidemiol Biomarkers Prev. 2010;19:2958-68 pubmed publisher
    ..Genotyping was carried out for SEP15 (rs5859, rs540049), SEPP1 (rs3877899, rs7579), GPX1 (rs1050450), and GPX4 (rs713041)...
  23. Xiong Y, Mo X, Zou X, Song R, Sun W, Lu W, et al. Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease. Osteoarthritis Cartilage. 2010;18:817-24 pubmed publisher
    ..Four polymorphisms including GPX1 (rs1050450), TrxR2 (rs5748469), SEPP1 (rs7579) and DIO2 (rs225014) were analyzed for 161 KBD patients and 312 ..
  24. Tang N, Wang L, Yang L, Gu H, Sun Q, Cong R, et al. Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population. Clin Chim Acta. 2008;395:89-93 pubmed publisher
    b>Glutathione peroxidase 1 (GPX1), the key antioxidant enzyme in vascular endothelial cells, has been shown to exert a protective effect against the presence of coronary artery disease (CAD)...
  25. Ratnasinghe D, Tangrea J, Andersen M, Barrett M, Virtamo J, Taylor P, et al. Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Cancer Res. 2000;60:6381-3 pubmed
    Human cellular glutathione peroxidase 1 (hGPX1) is a selenium-dependent enzyme that participates in the detoxification of hydrogen peroxide and a wide range of organic peroxides...
  26. Forsberg L, de Faire U, Marklund S, Andersson P, Stegmayr B, Morgenstern R. Phenotype determination of a common Pro-Leu polymorphism in human glutathione peroxidase 1. Blood Cells Mol Dis. 2000;26:423-6 pubmed
    ..the determination of the allelic frequency and phenotype of a common polymorphism in Se-dependent glutathione peroxidase 1 (GPX1) in Finnish/Swedish populations...
  27. Pera J, Slowik A, Dziedzic T, Pulyk R, Wloch D, Szczudlik A. Glutathione peroxidase 1 C593T polymorphism is associated with lobar intracerebral hemorrhage. Cerebrovasc Dis. 2008;25:445-9 pubmed publisher
    ..b>Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system...
  28. Zhuo P, Goldberg M, Herman L, Lee B, Wang H, Brown R, et al. Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme. Cancer Res. 2009;69:8183-90 pubmed publisher
    ..The collective data obtained using both lymphocytes and MCF-7 indicate that both intrinsic and extrinsic factors cooperate to ultimately determine the levels of this enzyme available to protect cells against DNA damage and mutagenesis. ..
  29. Hu J, Zhou G, Wang N, Wang Y. GPX1 Pro198Leu polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2010;124:425-31 pubmed publisher
    A genetic polymorphism at codon 198 in the human glutathione peroxidase 1 gene was reported to be associated with several cancers. However, this relationship remains controversial, especially in breast cancer...
  30. Méplan C, Hughes D, Pardini B, Naccarati A, Soucek P, Vodickova L, et al. Genetic variants in selenoprotein genes increase risk of colorectal cancer. Carcinogenesis. 2010;31:1074-9 pubmed publisher
    ..This study analysed 12 single-nucleotide polymorphisms (SNPs) in selenoprotein genes [glutathione peroxidase 1 (GPX1), GPX4, 15 kDa selenoprotein (SEP15), selenoprotein S (SELS), selenoprotein P (SEPP1) and ..
  31. Paz y Mino C, Muñoz M, López Cortés A, Cabrera A, Palacios A, Castro B, et al. Frequency of polymorphisms pro198leu in GPX-1 gene and ile58thr in MnSOD gene in the altitude Ecuadorian population with bladder cancer. Oncol Res. 2010;18:395-400 pubmed
    ..05). The results indicate that polymorphism of GPX-1 gene influences the risk of developing bladder cancer in the Ecuadorian population, suggesting that more research on detoxifying genes in bladder cancer should be conducted. ..
  32. Kasznicki J, Sliwinska A, Kosmalski M, Merecz A, Majsterek I, Drzewoski J. Genetic polymorphisms (Pro197Leu of Gpx1, +35A/C of SOD1, -262C/T of CAT), the level of antioxidant proteins (GPx1, SOD1, CAT) and the risk of distal symmetric polyneuropathy in Polish patients with type 2 diabetes mellitus. Adv Med Sci. 2016;61:123-9 pubmed publisher
    ..CAT), and glutathione peroxidase (GPX) and the association between polymorphic variants in genes encoding for GPx1, SOD, CAT and the risk of DSPN in T2DM patients...
  33. Durani L, Jaafar F, Tan J, Tajul Arifin K, Mohd Yusof Y, Wan Ngah W, et al. Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. Clin Ter. 2015;166:e365-73 pubmed publisher
    ..down-regulated SOD1 in pre-senescent and senescent HDFs, up-regulated SOD2 in senescent cells, CAT in young HDFs, GPX1 in young and pre-senescent HDFs, and CCS-1 in young, pre-senescent and senescent HDFs (p<0.05)...
  34. Zhou C, Zhao L, Zheng J, Wang K, Deng H, Liu P, et al. MicroRNA-144 modulates oxidative stress tolerance in SH-SY5Y cells by regulating nuclear factor erythroid 2-related factor 2-glutathione axis. Neurosci Lett. 2017;655:21-27 pubmed publisher
    ..To understand the effects of miR-144 on GSH biosynthesis and recycling, intracellular GPX1, glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM), glutathione ..
  35. Yang P, Mandrekar S, Hillman S, Allen Ziegler K, Sun Z, Wampfler J, et al. Evaluation of glutathione metabolic genes on outcomes in advanced non-small cell lung cancer patients after initial treatment with platinum-based chemotherapy: an NCCTG-97-24-51 based study. J Thorac Oncol. 2009;4:479-85 pubmed
    ..5, p = 0.05). Patients carrying the GPX1-CC genotype had a clinically significant decline in the UNISCALE (odds ratio (OR): 7.5; p = 0...
  36. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide. Ecotoxicol Environ Saf. 2017;135:173-182 pubmed publisher
    ..Upregulation in mRNA level of Cu-Zn Sod in liver and kidney was prominent. Gpx1 upregulation was more conspicuous in kidney as compared to liver while the pattern of Cat expression was almost ..
  37. Wei H, Pei J, Jiang C, Zhou L, Lan T, Liu M, et al. Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. Genet Mol Res. 2011;10:2996-3001 pubmed publisher
    ..Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD...
  38. Endres L, Begley U, Clark R, Gu C, Dziergowska A, Małkiewicz A, et al. Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage. PLoS ONE. 2015;10:e0131335 pubmed publisher
    ..expression of selenocysteine-containing ROS detoxification enzymes belonging to the glutathione peroxidase (Gpx1, Gpx3, Gpx6 and likely Gpx4) and thioredoxin reductase (TrxR1) families...
  39. Agardh E, Lundstig A, Perfilyev A, Volkov P, Freiburghaus T, Lindholm E, et al. Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. BMC Med. 2015;13:182 pubmed publisher
    ..of 349 CpG sites representing 233 unique genes including TNF, CHI3L1 (also known as YKL-40), CHN2, GIPR, GLRA1, GPX1, AHRR, and BCOR in cases with PDR compared with controls...
  40. Miar A, Hevia D, Muñoz Cimadevilla H, Astudillo A, Velasco J, Sainz R, et al. Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer. Free Radic Biol Med. 2015;85:45-55 pubmed publisher
    ..Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis.
  41. Zhang C, Guo L, Qin Y, Li G. Interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease. Chin Med J (Engl). 2015;128:2467-73 pubmed publisher
    ..5985 in the SI >400 subgroup) in increasing the risk of NAFLD. NAFLD risk factors include -420C/G (GG), Pro198Leu (LL) and cigarette smoking, and these three factors have a significant additive effect on NAFLD risk. ..
  42. Taeb M, Mortazavi Jahromi S, Jafarzadeh A, Mirzaei M, Mirshafiey A. An in vitro evaluation of anti-aging effect of guluronic acid (G2013) based on enzymatic oxidative stress gene expression using healthy individuals PBMCs. Biomed Pharmacother. 2017;90:262-267 pubmed publisher
    ..at low and high doses on the genes expression of a number of enzymes involved in oxidative stress (including SOD2, GPX1, CAT, GST, iNOS, and MPO) in peripheral blood mononuclear cells (PBMCs) of healthy individuals under in vitro ..
  43. Lee S, Jin J, Khoirinaya C, Kim G, Lee B. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85:575-84 pubmed publisher
    ..Significantly increased PPARγ, SREBF1, GPX1, and Bcl-2 and decreased Bax transcript levels were observed in mature oocytes treated with 50 μM of lanosterol ..
  44. Geraghty P, Baumlin N, SALATHE M, Foronjy R, D Armiento J. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Mediators Inflamm. 2016;2016:9461289 pubmed publisher
    ..Smoke inhalation also exacerbated the UPR response during respiratory syncytial virus infection. Therefore, ER stress may be an antioxidant-related pathophysiological event in COPD. ..
  45. Engelken J, Espadas G, Mancuso F, Bonet N, Scherr A, Jímenez Álvarez V, et al. Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver. Mol Biol Evol. 2016;33:738-54 pubmed publisher
    ..percentile in at least one HapMap population pair) and significant evidence for selective sweeps involving QTLs at GPX1, SELENBP1, GPX3, SLC30A9, and SLC39A8...
  46. Kondolot M, Ozmert E, Asci A, Erkekoglu P, Oztop D, Gumus H, et al. Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children. Environ Toxicol Pharmacol. 2016;43:149-58 pubmed publisher
    ..MEHP); thiobarbituric acid reactive substance (TBARS) and carbonyl groups; erythrocyte glutathione peroxidase (GPx1), thioredoxin reductase (TrxR), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) ..
  47. Morgan A, Han D, Lam W, Fraser A, Ferguson L. Association analysis of 3p21 with Crohn's disease in a New Zealand population. Hum Immunol. 2010;71:602-9 pubmed publisher
    ..The results from this study support the accumulating evidence that suggests the 3p21 region is a CD-associated locus, although it remains unclear which is the causative SNP and/or gene. ..
  48. Shuvalova Y, Kaminnyi A, Meshkov A, Kukharchuk V. Pro198Leu polymorphism of GPx-1 gene and activity of erythrocytic glutathione peroxidase and lipid peroxidation products. Bull Exp Biol Med. 2010;149:743-5 pubmed
    ..We concluded than free-radical oxidation processes are more pronounced in carriers of the minor allele of GPx-1 gene Pro198Leu polymorphism. ..
  49. Miranda Vilela A, Akimoto A, Alves P, Ferreira L, Lordelo G, Melo J, et al. Evidence for an association between haptoglobin and MnSOD (Val9Ala) gene polymorphisms in essential hypertension based on a Brazilian case-control study. Genet Mol Res. 2010;9:2166-75 pubmed publisher
    ..I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília...
  50. Yan J, Guo Y, Fei Y, Zhang R, Han Y, Lu S. GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress. Acta Biochim Biophys Sin (Shanghai). 2017;49:110-118 pubmed publisher
    b>Glutathione peroxidase 1 (GPx1) is a selenium (Se)-containing protein and is induced in cartilage formation. GPx1 eliminates reactive oxygen species (ROS), which are required for chondrogenic induction...
  51. Kim K, Heo D, Lee J, Seo C, Chung S. High-efficiency generation of induced pluripotent stem cells from human foreskin fibroblast cells using the Sagunja-tang herbal formula. BMC Complement Altern Med. 2017;17:529 pubmed publisher
    ..ROS) as well as promoted the activation of superoxide dismutase 1 (SOD1), catalase, gluthathione peroxidase 1 (GPX1), and glutathione (GSH)...
  52. Cardoso B, Busse A, Hare D, Cominetti C, Horst M, McColl G, et al. Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake. Food Funct. 2016;7:825-33 pubmed publisher
    ..of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium ..
  53. An R, Chu Y, Tian C, Dai X, Chen J, Shi Q, et al. Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX1. Acta Pharmacol Sin. 2008;29:1451-8 pubmed publisher
    ..Furthermore, the intracellular levels of p53 and p53- regulated gene GPX1 were obviously increased in the cells overexpressing nm23- H1...
  54. Ishibashi N, Prokopenko O, Weisbrot Lefkowitz M, Reuhl K, Mirochnitchenko O. Glutathione peroxidase inhibits cell death and glial activation following experimental stroke. Brain Res Mol Brain Res. 2002;109:34-44 pubmed
    ..cell death was accompanied with compromise of vascular integrity, edema and neutrophil infiltration, whereas GPx1 mice revealed significant preservation of tissue structure and decreased infiltration of acute inflammatory cells...
  55. Mrowicki J, Mrowicka M, Majsterek I, Mik M, Dziki A, Dziki Ł. Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population. Pol Przegl Chir. 2016;88:321-327 pubmed publisher
    ..and genotypes and alleles + 35A / C SOD1 in UC as well as polymorphic variants CAT -262 C / T, Pro197Leu of GPx1, + 35A / C SOD1 in CD...
  56. Dincer Y, Akcay T, Ilkova H, Alademir Z, Ozbay G. DNA damage and antioxidant defense in peripheral leukocytes of patients with Type I diabetes mellitus. Mutat Res. 2003;527:49-55 pubmed
    ..48, P<0.02); HbA(1c) and SOD (r = -0.50, P<0.02). In conclusion, impaired antioxidant defense in leukocytes of patients with Type 1 DM may be one of the responsible mechanisms for increased DNA damage in those patients. ..
  57. Choi W, Han J, Kim J, Kim M, Park J, Song B, et al. eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutr Metab (Lond). 2017;14:48 pubmed publisher
    ..phosphorylation because of diminished antioxidant capacity due to reduced expression of antioxidant enzymes (GPX1 and HO-1) and lower NADPH and glutathione levels, as well as a possible increase in ROS-induced damage from ..
  58. Jablonska E, Raimondi S, Gromadzinska J, Reszka E, Wieczorek E, Krol M, et al. DNA damage and oxidative stress response to selenium yeast in the non-smoking individuals: a short-term supplementation trial with respect to GPX1 and SEPP1 polymorphism. Eur J Nutr. 2016;55:2469-2484 pubmed
    ..The trial involved 95 non-smoking individuals, stratified according to GPX1 rs1050450 and SEPP1 rs3877899 genotypes, and supplemented with selenium yeast (200 µg) for 6 weeks...
  59. Felice F, Lucchesi D, Di Stefano R, Barsotti M, Storti E, Penno G, et al. Oxidative stress in response to high glucose levels in endothelial cells and in endothelial progenitor cells: evidence for differential glutathione peroxidase-1 expression. Microvasc Res. 2010;80:332-8 pubmed publisher
    ..This resistance to high glucose levels might be due to increased expression and activity of glutathione peroxidase allowing better cell survival. ..
  60. Ishida Y, Yamasaki M, Yukizaki C, Nishiyama K, Tsubouchi H, Okayama A, et al. Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis. Hum Cell. 2014;27:68-77 pubmed publisher
    ..From these results, it was suggested that the apoptosis-inducing activity of carnosol in ATL cells was caused by the depletion of glutathione. ..
  61. da Cunha Martins A, Mazzaron Barcelos G, Jacob Ferreira A, de Souza M, de Syllos Cólus I, Antunes L, et al. Effects of Lead Exposure and Genetic Polymorphisms on ALAD and GPx Activities in Brazilian Battery Workers. J Toxicol Environ Health A. 2015;78:1073-81 pubmed publisher
    ..Further, the rs1800435 SNP showed a tendency to modulate ALAD activity, while the rs1800668 SNP did not modulate GPx activity in Brazilian automotive battery workers exposed to Pb. ..
  62. Tang T, Prior S, Li K, Ireland H, Bain S, Hurel S, et al. Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus. Nutr Metab Cardiovasc Dis. 2012;22:417-25 pubmed publisher
    ..Prospective analysis of the gene variant is required in diabetic and healthy cohorts with measured plasma markers of oxidative stress to investigate the described association further. ..
  63. Lubos E, Kelly N, Oldebeken S, Leopold J, Zhang Y, Loscalzo J, et al. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011;286:35407-17 pubmed publisher
    ..Targeted DUSP4 knockdown enhanced TNF-α-mediated ERK1/2 pathway activation and resulted in increased adhesion molecule expression, indicating that GPx-1 deficiency may augment TNF-α-mediated events, in part, by regulating DUSP4. ..
  64. Schlörmann W, Lamberty J, Ludwig D, Lorkowski S, Glei M. In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. Nutr Res. 2017;47:72-80 pubmed publisher
    ..After treatment of LT97 colon adenoma cells with fermentation supernatants (FSs), expression of CAT, SOD2, GPx1, GSTP1, and GSTT2 genes as well as cell growth and apoptosis was examined...
  65. Hamdi M, Lopera Vasquez R, Maillo V, Sánchez Calabuig M, Núñez C, Gutierrez Adan A, et al. Bovine oviductal and uterine fluid support in vitro embryo development. Reprod Fertil Dev. 2017;: pubmed publisher
    ..exhibited downregulation of oxidative stress genes compared to SOF+BSA and OF groups for glutathione peroxidase (GPX1) and to SOF+FCS, SOF+BSA and OF groups for chloride intracellular channel 1 (CLIC1) (P<0.05)...
  66. Hua X, Chi W, Su L, Li J, Zhang Z, Yuan X. ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation. Sci Rep. 2017;7:10421 pubmed publisher
    ..COX2), with suppressed levels of antioxidant enzymes, superoxide dismutase-1 (SOD1), glutathione peroxidase-1 (GPx1) and peroxiredoxin-4 (PRDX4)...
  67. Hong S, Hong L, Li B, Wu D, Liu C, Min J, et al. The role of GPX1 in the pathogenesis of female pelvic organ prolapse. PLoS ONE. 2017;12:e0181896 pubmed publisher
    ..Our previous research showed that the expression of glutathione peroxidase type 1 (GPX1) decreased in pelvic floor ligaments from POP patients, implying that oxidative stress (OS) may be related to POP...
  68. Richard M, Guiraud P, Didier C, Seve M, Flores S, Favier A. Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. Arch Biochem Biophys. 2001;386:213-20 pubmed
    ..All these disturbances, as well as the previously described decrease in Mn superoxide dismutase activity, are part of the viral strategy to modify the redox potential of cells and may have important consequences for patients. ..
  69. Bürkert E, Arnold C, Hammarberg T, Radmark O, Steinhilber D, Werz O. The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. J Biol Chem. 2003;278:42846-53 pubmed
    ..In summary, our data suggest that interaction of Ca2+ at the C2-like domain of 5-LO protects the enzyme against the effect of GPx-1. Apparently, in the presence of Ca2+, a low lipid hydroperoxide level is sufficient for 5-LO activation. ..
  70. Rocha A, Rita Cardoso B, Zavarize B, Almondes K, Bordon I, Hare D, et al. GPX1 Pro198Leu polymorphism and GSTM1 deletion do not affect selenium and mercury status in mildly exposed Amazonian women in an urban population. Sci Total Environ. 2016;571:801-8 pubmed publisher
    ..the possible interaction between these two elements, we aimed to assess the effects of Pro198Leu polymorphism to GPX1 and GSTM1 deletion, on mercury levels in a population from Porto Velho, an urban locality in the Brazilian Amazon ..
  71. Lenormand C, Couteau J, Nouhaud F, Maillet G, Bou J, Gobet F, et al. Predictive Value of NRAMP1 and HGPX1 Gene Polymorphism for Maintenance BCG Response in Non-muscle-invasive Bladder Cancer. Anticancer Res. 2016;36:1737-43 pubmed
    ..the potential predictive value of natural resistance-associated macrophage protein 1 (NRAMP1) and human glutathione peroxidase 1 (hGPX1) polymorphism in non-muscle-invasive bladder cancer treated with bacillus Calmette-Guerin (BCG) ..
  72. Skuladottir H, Autrup H, Autrup J, Tjoenneland A, Overvad K, Ryberg D, et al. Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. Lung Cancer. 2005;48:187-99 pubmed
    ..and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2...
  73. Oestergaard M, Tyrer J, Cebrian A, Shah M, Dunning A, Ponder B, et al. Interactions between genes involved in the antioxidant defence system and breast cancer risk. Br J Cancer. 2006;95:525-31 pubmed
    ..The 10 genes are SOD1, SOD2, GPX1, GPX4, GSR, CAT, TXN, TXN2, TXNRD1 and TXNRD2...
  74. Hernández Guerrero C, Hernández Chávez P, Martínez Castro N, Parra Carriedo A, García Del Rio S, Pérez Lizaur A. GLUTATHIONE PEROXIDASE-1 PRO200LEU POLYMORPHISM (RS1050450) IS ASSOCIATED WITH MORBID OBESITY INDEPENDENTLY OF THE PRESENCE OF PREDIABETES OR DIABETES IN WOMEN FROM CENTRAL MEXICO. Nutr Hosp. 2015;32:1516-25 pubmed publisher
    ..El estrés oxidativo está presente de manera significativa en todos los grados de obesidad. ..