Gene Symbol: GPS1
Description: G protein pathway suppressor 1
Alias: COPS1, CSN1, SGN1, COP9 signalosome complex subunit 1, JAB1-containing signalosome subunit 1
Species: human
Products:     GPS1

Top Publications

  1. Lyapina S, Cope G, Serino G, Tsuge T, Zhou C, Wolf D, et al. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science. 2001;292:1382-5 pubmed
  2. Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech Otschir D, et al. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 2003;22:1302-12 pubmed
    ..Curcumin treatment results in elevated amounts of c-Jun-Ub conjugates. We conclude that CK2 and PKD are recruited by CSN in order to regulate Ub conjugate formation. ..
  3. da Silva Correia J, Miranda Y, Leonard N, Ulevitch R. The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J Biol Chem. 2007;282:12557-65 pubmed
    The COP9 signalosome is a large multiprotein complex that consists of eight subunits termed CSN1-CSN8...
  4. Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher of 35 subcomplexes, we are able to build a comprehensive interaction map that shows two symmetrical modules, Csn1/2/3/8 and Csn4/5/6/7, connected by interactions between Csn1-Csn6...
  5. Emberley E, Mosadeghi R, Deshaies R. Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem. 2012;287:29679-89 pubmed publisher
    ..Upon consumption of substrate and subsequent deneddylation, CSN can remain stably bound to the CRL and hold it in low state of reduced activity. ..
  6. Min K, Kwon M, Park H, Park Y, Yoon S, Yoon J. CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun. 2005;334:867-74 pubmed
    ..Our data suggest that enhancement of CSN-mediated deneddylation by CAND1 may contribute to its function as a positive regulator of SCFs in vivo. ..
  7. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell. 2003;113:357-67 pubmed
    ..Knockdown of CSN with RNA interference leads to defects in NER. These results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of NER. ..
  8. Bech Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001;20:1630-9 pubmed
    ..It induces the cyclin-dependent inhibitor p21. In HeLa and MCF-7 cells, inhibition of CSN kinase by curcumin or Deltap53(145-164) results in accumulation of endogenous p53. ..
  9. Tsuge T, Matsui M, Wei N. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J Mol Biol. 2001;305:1-9 pubmed
    ..In this study, we dissected structure and function of the subunit 1 (CSN1 or GPS1) of the COP9 signalosome relative to the complex...

More Information


  1. Kapelari B, Bech Otschir D, Hegerl R, Schade R, Dumdey R, Dubiel W. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J Mol Biol. 2000;300:1169-78 pubmed
    ..Although substrate phosphorylation by COP9 signalosome is significantly decreased by lambda protein phosphatase treatment, "autophosphorylation" is increased. ..
  2. Huang X, Hetfeld B, Seifert U, Kahne T, Kloetzel P, Naumann M, et al. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005;272:3909-17 pubmed
    ..The possible role of super-complexes composed of the CSN, the 26S proteasome and of Ub ligases in the regulation of protein stability is discussed. ..
  3. Lingaraju G, Bunker R, Cavadini S, Hess D, Hassiepen U, Renatus M, et al. Crystal structure of the human COP9 signalosome. Nature. 2014;512:161-5 pubmed publisher
    ..We find that neddylated CRL binding to CSN is sensed by CSN4, and communicated to CSN5 with the assistance of CSN6, resulting in activation of the deneddylase. ..
  4. Li Z, Lim S, Liang X, Lim Y. The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. J Biol Chem. 2018;293:20014-20028 pubmed publisher
    ..of Wnt, revealing that WBP2 primes cells to Wnt activity by up-regulating G protein pathway suppressor 1 (GPS1) and TRAF2- and NCK-interacting kinase (TNIK)...
  5. Rizza A, Walia A, Tang B, Jones A. Visualizing Cellular Gibberellin Levels Using the nlsGPS1 Förster Resonance Energy Transfer (FRET) Biosensor. J Vis Exp. 2019;: pubmed publisher
    ..Gibberellin Perception Sensor 1 (GPS1) is the first Förster resonance energy transfer (FRET)-based biosensor that allows monitoring of cellular GA ..
  6. Singh C, Kaur S, George J, Nihal M, Pellitteri Hahn M, Scarlett C, et al. Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach. Oncotarget. 2015;6:10335-48 pubmed
    ..Four of these proteins (IL33, CUL5, GPS1 and DUSP4) appear to occupy regulatory nodes in key pathways...
  7. Bayne E, Bijos D, White S, de Lima Alves F, Rappsilber J, Allshire R. A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast. Genome Biol. 2014;15:481 pubmed
    ..are required for proper processing of centromeric transcripts by the RNAi pathway, and COP9 signalosome components Csn1 and Csn2, whose role in heterochromatin assembly can be explained at least in part by a role in the Ddb1-dependent ..
  8. Ma X, Xu M, Jiang T. Crystal structure of the human CSN6 MPN domain. Biochem Biophys Res Commun. 2014;453:25-30 pubmed publisher
    The mammalian COP9 signalosome is an eight-subunit (CSN1-CSN8) complex that plays essential roles in multiple cellular and physiological processes...
  9. Beckmann E, Köhler A, Meister C, Christmann M, Draht O, Rakebrandt N, et al. Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly. Mol Microbiol. 2015;97:110-24 pubmed publisher
    ..The CSN1/CsnA N-terminus is dispensable for deneddylase activity but required for asexual spore formation...
  10. Pan L, Wang S, Lu T, Weng C, Song X, Park J, et al. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014;514:233-6 pubmed publisher
    ..The COP9 complex is composed of eight Csn subunits, Csn1-8, and removes Nedd8 modifications from target proteins...
  11. Suzuki S, Ishii S, Hoshino T, Rietze A, Tenney A, Morrill P, et al. Unusual metabolic diversity of hyperalkaliphilic microbial communities associated with subterranean serpentinization at The Cedars. ISME J. 2017;11:2584-2598 pubmed publisher
    ..Here, we report the metagenomic data and recovered draft genomes from two different springs, GPS1 and BS5...
  12. Toyokawa T, Kubo N, Tamura T, Sakurai K, Amano R, Tanaka H, et al. The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study. BMC Cancer. 2016;16:722 pubmed publisher
    ..612 for NLR. The high-CONUT group was significantly associated with lower BMI, high-PLR, high-NLR, and GPS1/2 groups...
  13. Ba M, Surina J, Singer C, Valencik M. Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway. BMC Pharmacol Toxicol. 2017;18:47 pubmed publisher
    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex...
  14. Okuno T, Wakabayashi M, Kato K, Shinoda M, Katayama H, Igaki H, et al. Esophageal stenosis and the Glasgow Prognostic Score as independent factors of poor prognosis for patients with locally advanced unresectable esophageal cancer treated with chemoradiotherapy (exploratory analysis of JCOG0303). Int J Clin Oncol. 2017;22:1042-1049 pubmed publisher
    ..If only CRP was increased or only albumin was decreased, the patients were classified as GPS1, and the patients with CRP >1.0 mg/dL and albumin <3.5 g/dL were classified as GPS2...
  15. Wang H, Miao Q, Xu Q, He X, Xu B. Translation of Exercise Test Response to Training Intensity Using the Count Scale. Respir Care. 2016;61:220-4 pubmed publisher
    ..During the first session, in which exercise was guided by the heart rate, the CSN and heart rate were obtained (ie, CSN1 and HR1) while the heart rate was increased by 20% compared with the resting heart rate...
  16. Kimball P, Gupta G, McDougan F. Circulating angiotensin type II receptor: Possible marker for antibody mediated rejection after renal transplantation?. Hum Immunol. 2017;78:629-633 pubmed publisher
    ..One-year posttransplant levels approached [p<0.01] normalcy for Gps1+3 but spiked during AMR and remained elevated [155±58, p<0.01] for 50% Gp2 patients...
  17. Su H, Li J, Zhang H, Ma W, Wei N, Liu J, et al. COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity. Circ Res. 2015;117:956-66 pubmed publisher
    ..The cullin deneddylation activity of the COP9 signalosome (CSN) requires all 8 CSN subunits (CSN1 through CSN8) and regulates cullin-RING ligases, thereby controlling ubiquitination of a large number of proteins; ..
  18. Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, et al. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Mol Med Rep. 2016;14:4559-4566 pubmed publisher
    Constitutive photomorphogenesis 9 signalosome (CSN) consists of a total of eight subunits (CSN1-CSN8) in mammalian cells...
  19. Meitinger F, Pereira G. The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Mol Biol Cell. 2017;28:883-889 pubmed publisher
    ..In budding yeast, the protein Gps1 plays a pivotal role in both processes...
  20. Ohira M, Kubo N, Masuda G, Yamashita Y, Sakurai K, Toyokawa T, et al. Glasgow Prognostic Score as a Prognostic Clinical Marker in T4 Esophageal Squamous Cell Carcinoma. Anticancer Res. 2015;35:4897-901 pubmed
    ..Curative tumor resection was undertaken in suitable patients on completing CRT. Patients were classified as GPS0, GPS1, or GPS2 based on C-reactive protein (CRP) ≤ 10 mg/l and albumin ≥ 35 g/l, CRP >10 mg/l or albumin <35 g/..
  21. Korczeniewska J, Barnes B. Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability. Mol Cell Biol. 2018;38: pubmed publisher
    ..Degradation was further augmented by knockdown of CSN1 and CSN3 together...
  22. Horn A, Zeuner H, Wolf H, Schnitker J, Wüstenberg E. Health-Related Quality of Life During Routine Treatment with the SQ-Standardised Grass Allergy Immunotherapy Tablet: A Non-Interventional Observational Study. Clin Drug Investig. 2016;36:453-62 pubmed publisher
    ..Survey (SF-12) and the Rhinitis Quality of Life Questionnaire (RQLQ) in the grass pollen seasons (GPS) at baseline (GPS1, HRQoL1), after GPS1 (HRQoL2) and in the following GPS (GPS2, HRQoL3)...
  23. Morinaga S, Murakawa M, Katayama Y, Yamaoku K, Aoyama T, Kanazawa A, et al. Glasgow Prognostic Score Predicts Clinical Outcomes in Patients with Pancreatic Cancer Undergoing Adjuvant Gemcitabine Monotherapy After Curative Surgery. Anticancer Res. 2015;35:4865-70 pubmed
    ..The disease-free survival (DFS) and overall survival (OS) in patients with an elevated GPS (GPS1 or GPS2) were significantly poorer (p=0.001 and p=0...
  24. McCall C, Miliani de Marval P, Chastain P, Jackson S, He Y, Kotake Y, et al. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008;28:5621-33 pubmed publisher
    ..Our studies identify a previously unknown function of VprBP in S-phase progression and suggest the possibility that HIV-1 Vpr may divert an ongoing chromosomal replication activity to facilitate viral replication. ..
  25. Rao F, Xu J, Khan A, Gadalla M, Cha J, Xu R, et al. Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proc Natl Acad Sci U S A. 2014;111:16005-10 pubmed publisher
    ..Thus, IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. ..
  26. Pick E, Golan A, Zimbler J, Guo L, Sharaby Y, Tsuge T, et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS ONE. 2012;7:e43980 pubmed publisher
    ..The classic CSN is composed of 8 subunits (Csn1-8), yet in several Ascomycota, the complex is smaller and lacks orthologs for a few CSN subunits, but nevertheless ..
  27. Scherer P, Ding Y, Liu Z, Xu J, Mao H, Barrow J, et al. Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc Natl Acad Sci U S A. 2016;113:3503-8 pubmed publisher
    ..Thus, IP5K and IP6 are evolutionarily conserved components of the CRL-CSN system and are potential targets for cancer therapy in conjunction with MLN4924. ..
  28. Tsuge T, Menon S, Tong Y, Wei N. CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Protein Cell. 2011;2:423-32 pubmed publisher
    b>CSN1 is a component of the COP9 signalosome (CSN), a conserved protein complex with pleiotropic functions in many organs and cell types...
  29. Li J, Chai B, Zhang W, Liu Y, Ammori J, Mulholland M. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. Cell Signal. 2007;19:1185-92 pubmed
    ..a bait, we screened mouse testis and arcuate nucleus cDNA libraries and identified G-protein pathway suppressor 1 (GPS1, also known as CSN1) as an Asb-4 interacting protein...
  30. Cavadini S, Fischer E, Bunker R, Potenza A, Lingaraju G, Goldie K, et al. Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature. 2016;531:598-603 pubmed publisher
    ..These architectural and regulatory principles appear conserved across CRL families, allowing global regulation by CSN. ..
  31. Feber A, Worth D, Chakravarthy A, de Winter P, Shah K, Arya M, et al. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer Res. 2016;76:4720-4727 pubmed publisher
    ..We also identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1 Expression of CSN1 mutants in cells resulted in colocalization with AGO2 in cytoplasmic P-bodies, ..
  32. Seeger M, Kraft R, Ferrell K, Bech Otschir D, Dumdey R, Schade R, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998;12:469-78 pubmed
    ..Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1-containing signalosome. ..
  33. Oh W, Lee E, Sung Y, Yang M, Ghim J, Lee H, et al. Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem. 2006;281:17457-65 pubmed
    ..Our studies implicate that Jab1 is required to remove post-translationally modified p53 and provide a novel target for p53-related cancer therapies. ..
  34. Chun Y, Lee M, Park B, Lee S. CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation. J Biol Chem. 2013;288:27208-19 pubmed publisher
  35. Kulaksiz G, Reardon J, Sancar A. Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties. Mol Cell Biol. 2005;25:9784-92 pubmed
  36. Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell. 2003;15:719-31 pubmed
    ..Comparative analyses of the subunit interaction of CSN revealed a set of conserved subunit contacts and resulted in a model of CSN subunit topology, some aspects of which were substantiated by in vivo cross-link tests. ..
  37. Welteke V, Eitelhuber A, Duwel M, Schweitzer K, Naumann M, Krappmann D. COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation. EMBO Rep. 2009;10:642-8 pubmed publisher
    ..Taken together, our data provide evidence for a functional link between the evolutionarily conserved CSN and the adaptive immunoregulatory CBM complex in T cells. ..
  38. Stotland A, Pruitt L, Webster P, Wolkowicz R. Purification of the COP9 signalosome complex and binding partners from human T cells. OMICS. 2012;16:312-9 pubmed publisher
    ..method for the CSN and binding proteins via the Streptavidin-Binding Peptide (SBP) fused to CSN Subunit 1 (CSN1)...
  39. Cayli S, Demirturk F, Ocakli S, Aytan H, Caliskan A, Cimsir H. Altered expression of COP9 signalosome proteins in preeclampsia. Gynecol Endocrinol. 2012;28:488-91 pubmed publisher
    ..Thus, this study was aimed to show the localization and the protein expression of CSN1 and CSN5 in normal and preeclamptic placenta...
  40. Lee J, Sweredoski M, Graham R, Kolawa N, Smith G, Hess S, et al. The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Mol Cell Proteomics. 2011;10:M110.006460 pubmed publisher
    ..We suggest that multiple mechanisms including FBP dissociation and turnover cooperate to maintain the cellular pool of SCF ubiquitin ligases. ..
  41. Dubois E, Gerber S, KISSELEV A, Harel Bellan A, Groisman R. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Oncol Rep. 2016;35:3101-5 pubmed publisher
    ..we demonstrated that the protein kinase ATM, a key component of the DNA damage response (DDR), phosphorylates CSN1 and CSN7a, two subunits of the CSN complex, in a UV-dependent manner...
  42. Sun Y, Wilson M, Majerus P. Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. J Biol Chem. 2002;277:45759-64 pubmed
    ..The association of 5/6-kinase with the COP9 signalosome is through an interaction with CSN1, which immunoprecipitates with 5/6-kinase...
  43. Lee J, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, et al. Crystal structure and versatile functional roles of the COP9 signalosome subunit 1. Proc Natl Acad Sci U S A. 2013;110:11845-50 pubmed publisher
    ..It is an evolutionarily conserved eight-protein complex with subunits CSN1 to CSN8 named following the descending order of molecular weights...
  44. Füzesi Levi M, Ben Nissan G, Bianchi E, Zhou H, Deery M, Lilley K, et al. Dynamic regulation of the COP9 signalosome in response to DNA damage. Mol Cell Biol. 2014;34:1066-76 pubmed publisher
    ..of the CSN complex into the nucleus was seen, accompanied by upregulation of specific phosphorylations within CSN1, CSN3, and CSN8...
  45. Spain B, Bowdish K, Pacal A, Staub S, Koo D, Chang C, et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996;16:6698-706 pubmed
    We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of the yeast Saccharomyces cerevisiae...
  46. Hoareau Alves K, Bochard V, Rety S, Jalinot P. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. FEBS Lett. 2002;527:15-21 pubmed
    ..Taken together these results show that the Int-6 protein can bind the three complexes with various efficiencies, possibly exerting a regulatory activity in both protein translation and degradation. ..
  47. Rizza A, Walia A, Lanquar V, Frommer W, Jones A. In vivo gibberellin gradients visualized in rapidly elongating tissues. Nat Plants. 2017;3:803-813 pubmed publisher
    ..Using a combinatorial screen in yeast, we engineered an optogenetic biosensor, GIBBERELLIN PERCEPTION SENSOR 1 (GPS1), that senses nanomolar levels of bioactive GAs...
  48. Schweitzer K, Naumann M. CSN-associated USP48 confers stability to nuclear NF-κB/RelA by trimming K48-linked Ub-chains. Biochim Biophys Acta. 2015;1853:453-69 pubmed publisher
    ..Thereby USP48 contributes to a timely control of immune responses. ..
  49. Wang Y, Lu C, Wei H, Wang N, Chen X, Zhang L, et al. Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity. FEBS Lett. 2004;572:85-91 pubmed
    ..Taken together, these results elucidate a novel relationship of intracellular growth factor, HPO with large protein complex, CSN, which suggests a possible linkage between CSN and liver regeneration. ..
  50. Galgano D, Onnis A, Pappalardo E, Galvagni F, Acuto O, Baldari C. The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci. 2017;130:1110-1121 pubmed publisher
    ..known as TRAF3IP1), GMAP-210 (also known as TRIP11), Arp2/3 complex subunit-3 (ARPC3), COP9 signalosome subunit-1 (CSN1, also known as GPS1) and ERGIC-53 (also known as LMAN1)...
  51. Fousteri M, Vermeulen W, Van Zeeland A, Mullenders L. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell. 2006;23:471-82 pubmed
    ..These results give insight into the nature and order of molecular events that take place during TCR in the context of chromosomal DNA. ..
  52. Huang X, Ordemann J, Pratschke J, Dubiel W. Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation. FEBS Open Bio. 2016;6:1102-1112 pubmed
  53. Menon S, Tsuge T, Dohmae N, Takio K, Wei N. Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem. 2008;9:1 pubmed publisher
    ..We report isolation of SAP130 (SF3b-3) as a CSN1 interacting protein...
  54. Enchev R, Schreiber A, Beuron F, Morris E. Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. Structure. 2010;18:518-27 pubmed publisher
    ..We compare the structure of CSN with its homologous complexes, the 26S proteasome lid and eIF3, and propose a conserved architecture implying similar assembly pathways and/or conserved substrate interaction modes. ..
  55. Rozen S, Füzesi Levi M, Ben Nissan G, Mizrachi L, Gabashvili A, Levin Y, et al. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. Cell Rep. 2015;13:585-598 pubmed publisher
    ..Finally, on the basis of sequence and structural properties shared by both CSNAP and DSS1, a component of the related 19S lid proteasome complex, we propose that CSNAP, the ninth CSN subunit, is the missing paralogous subunit of DSS1. ..
  56. Christmann M, Schmaler T, Gordon C, Huang X, Bayram Ö, Schinke J, et al. Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. PLoS Genet. 2013;9:e1003275 pubmed publisher
    ..A deneddylase disequilibrium impairs multicellular development and suggests that control of deneddylase activity is important for multicellular development. ..
  57. Zitouni M, Viens P, Ghinet M, Brzezinski R. Diversity of family GH46 chitosanases in Kitasatospora setae KM-6054. Appl Microbiol Biotechnol. 2017;101:7877-7888 pubmed publisher
    ..The genes (csn1-3) were cloned in Streptomyces lividans and the corresponding enzymes were purified from the recombinant cultures...