Gene Symbol: GPNMB
Description: glycoprotein nmb
Alias: HGFIN, NMB, PLCA3, transmembrane glycoprotein NMB, glycoprotein (transmembrane) nmb, glycoprotein nmb-like protein, glycoprotein nonmetastatic melanoma protein B, hematopoietic growth factor inducible neurokinin-1, osteoactivin, transmembrane glycoprotein HGFIN
Species: human
Products:     GPNMB

Top Publications

  1. Haralanova Ilieva B, Ramadori G, Armbrust T. Expression of osteoactivin in rat and human liver and isolated rat liver cells. J Hepatol. 2005;42:565-72 pubmed
    The transmembrane glycoprotein osteoactivin is expressed in osteoblasts, dendritic cells and tumor cells. It is suggested to influence osteoblast maturation, cell adhesion and migration. We studied osteoactivin expression within the liver...
  2. Metz R, Yehia G, Fernandes H, Donnelly R, Rameshwar P. Cloning and characterization of the 5' flanking region of the HGFIN gene indicate a cooperative role among p53 and cytokine-mediated transcription factors: relevance to cell cycle regulation. Cell Cycle. 2005;4:315-22 pubmed
    HGFIN, previously identified as nmb, and its homologs, osteoactivin are single transmembrane protein that is expressed in differentiated immune cells, and are linked to tumor progression...
  3. Kuan C, Wakiya K, Dowell J, Herndon J, Reardon D, Graner M, et al. Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res. 2006;12:1970-82 pubmed
    ..promising molecular therapeutic glioblastoma multiforme (GBM) targets: human transmembrane glycoprotein nonmetastatic melanoma protein B (GPNMB(wt)) and a splice variant form (GPNMB(sv), a 12-amino-acid in-frame insertion in the ..
  4. Tomihari M, Hwang S, Chung J, Cruz P, Ariizumi K. Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion. Exp Dermatol. 2009;18:586-95 pubmed publisher
    b>Gpnmb is a glycosylated transmembrane protein implicated in the development of glaucoma in mice and melanoma in humans. It shares significant amino acid sequence homology with the melanosome protein Pmel-17...
  5. Weterman M, Ajubi N, van Dinter I, Degen W, Van Muijen G, Ruitter D, et al. nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. Int J Cancer. 1995;60:73-81 pubmed
    ..One clone, designated nmb, showed preferential expression in the low-metastatic cell lines and was chosen for further characterization...
  6. Loftus S, Antonellis A, Matera I, Renaud G, Baxter L, Reid D, et al. Gpnmb is a melanoblast-expressed, MITF-dependent gene. Pigment Cell Melanoma Res. 2009;22:99-110 pubmed publisher
    Expression profile analysis clusters Gpnmb with known pigment genes, Tyrp1, Dct, and Si. During development, Gpnmb is expressed in a pattern similar to Mitf, Dct and Si with expression vastly reduced in Mitf mutant animals...
  7. Rose A, Grosset A, Dong Z, Russo C, MacDonald P, Bertos N, et al. Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clin Cancer Res. 2010;16:2147-56 pubmed publisher
    Although the murine orthologue of glycoprotein nonmetastatic B (GPNMB), Osteoactivin, promotes breast cancer metastasis in an in vivo mouse model, its importance in human breast cancer is unknown...
  8. Rose A, Annis M, Dong Z, Pepin F, Hallett M, Park M, et al. ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties. PLoS ONE. 2010;5:e12093 pubmed publisher
    Glycoprotein non-metastatic melanoma protein B (GPNMB)/Osteoactivin (OA) is a transmembrane protein expressed in approximately 40-75% of breast cancers...
  9. Schwarzbich M, Gutknecht M, Salih J, Salih H, Brossart P, Rittig S, et al. The immune inhibitory receptor osteoactivin is upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors. Cancer Immunol Immunother. 2012;61:193-202 pubmed publisher
    ..imatinib, dasatinib, and nilotinib results in profound upregulation of the transmembrane glycoprotein osteoactivin that has recently been characterized as a negative regulator of T-cell activation...

More Information

Publications121 found, 100 shown here

  1. Owen T, Smock S, Prakash S, Pinder L, Brees D, Krull D, et al. Identification and characterization of the genes encoding human and mouse osteoactivin. Crit Rev Eukaryot Gene Expr. 2003;13:205-20 pubmed
    b>Osteoactivin (OA) is more highly expressed in the bones of osteopetrotic mutant rats (op/op) than in those of their normal littermates and is the homologue of human nmb, a cDNA more highly expressed in melanoma-derived cell lines of low ..
  2. Williams M, Esmaeli B, Soheili A, Simantov R, Gombos D, Bedikian A, et al. GPNMB expression in uveal melanoma: a potential for targeted therapy. Melanoma Res. 2010;20:184-90 pubmed publisher
    ..High expression of glycoprotein-NMB (GPNMB) in cutaneous melanomas led to the development of CDX-011 (glembatumumab vedotin), a fully human monoclonal ..
  3. Ahn J, Lee Y, Jeon C, Lee S, Lee B, Choi K, et al. Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis. Blood. 2002;100:1742-54 pubmed
    ..quot; (4) The genes for immunoglobulin (Ig) superfamily Z39Ig, CD20-like precursor, glycoprotein NMB (GPNMB), transforming growth factorbeta (TGF-beta)-induced protein (TGFBI), myeloid DAP12-associated lectin (MDL-1), and ..
  4. Bächner D, Schröder D, Gross G. mRNA expression of the murine glycoprotein (transmembrane) nmb (Gpnmb) gene is linked to the developing retinal pigment epithelium and iris. Brain Res Gene Expr Patterns. 2002;1:159-65 pubmed
    The murine homologue of the human glycoprotein (transmembrane) NMB (GPNMB) gene was identified by subtractive cloning from in vitro cultured murine primary osteoblast cells and subsequent RACE-PCR...
  5. Rose A, Pepin F, Russo C, Abou Khalil J, Hallett M, Siegel P. Osteoactivin promotes breast cancer metastasis to bone. Mol Cancer Res. 2007;5:1001-14 pubmed
    ..Gene expression profiling identified osteoactivin as a candidate that is highly and selectively expressed in aggressively bone metastatic breast cancer cells...
  6. Chung J, Bonkobara M, Tomihari M, Cruz P, Ariizumi K. The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses. Eur J Immunol. 2009;39:965-74 pubmed publisher
    ..Our findings indicate that the DC-HIL/SD-4 pathway can be manipulated to treat T-cell-driven disorders in humans. ..
  7. Hoashi T, Sato S, Yamaguchi Y, Passeron T, Tamaki K, Hearing V. Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein. FASEB J. 2010;24:1616-29 pubmed publisher
    ..More than 150 pigmentation-related genes have been identified, including glycoprotein nonmetastatic melanoma protein b (GPNMB)...
  8. Tanaka H, Shimazawa M, Kimura M, Takata M, Tsuruma K, Yamada M, et al. The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis. Sci Rep. 2012;2:573 pubmed publisher
    ..Despite substantial research, the causes of ALS remain unclear. Glycoprotein nonmetastatic melanoma protein B (GPNMB) was identified as an ALS-related factor using DNA microarray analysis with mutant ..
  9. Cardoso A, Fernandes A, Aguilar Pimentel J, de Angelis M, Guedes J, Brito M, et al. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 2018;47:214-277 pubmed publisher
    ..ghrelin (GHRL), growth hormone (GH), (7) microparticle panel (to be further defined), GpnmB (glycoprotein nonmetastatic melanoma protein B) and lactoferrin (LTF)...
  10. Kusanovic J, Romero R, Chaiworapongsa T, Mittal P, Mazaki Tovi S, Vaisbuch E, et al. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med. 2010;23:34-47 pubmed publisher
    ..We propose that sTREM-1 play a role in the innate immune response against intra-amniotic infection. ..
  11. Horst A, Najjar S, Wagener C, Tiegs G. CEACAM1 in Liver Injury, Metabolic and Immune Regulation. Int J Mol Sci. 2018;19: pubmed publisher
    ..This review focuses on the regulatory role of CEACAM1 in liver and biliary tract architecture in health and disease, and on its metabolic role and function as an immune checkpoint regulator of hepatic inflammation. ..
  12. Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, et al. Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice. Arterioscler Thromb Vasc Biol. 2016;36:636-46 pubmed publisher
    ..These results indicate the crucial roles of intracellular and extracellular Bsg in the pathogenesis of cardiac hypertrophy, fibrosis, and failure in mice and humans. ..
  13. Tagliaferri C, Wittrant Y, Davicco M, Walrand S, Coxam V. Muscle and bone, two interconnected tissues. Ageing Res Rev. 2015;21:55-70 pubmed publisher
    ..fibroblast growth factor (FGF-2), interleukin-6 (IL-6), IL-15, myostatin, osteoglycin (OGN), FAM5C, Tmem119 and osteoactivin. Even though studies on the potential effects of bone on muscle metabolism are sparse, few osteokines have been ..
  14. Itai S, Yamada S, Kaneko M, Harada H, Kagawa Y, Konnai S, et al. Expression of Cat Podoplanin in Feline Squamous Cell Carcinomas. Monoclon Antib Immunodiagn Immunother. 2017;: pubmed publisher
    ..In particular, 12 cases (30%) showed a strong membrane-staining pattern of squamous cell carcinoma cells. PMab-52 can be useful for antibody therapy against feline podoplanin-expressing squamous cell carcinomas...
  15. Ma L, Dong L, Chang P. CD44v6 engages in colorectal cancer progression. Cell Death Dis. 2019;10:30 pubmed publisher
    ..Thus, we are hopeful that anti-CD44 therapy will be applied in the treatment of colorectal cancer in the future. ..
  16. Sikorska J, Gaweł D, Domek H, Rudzinska M, Czarnocka B. Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases. BMC Cancer. 2019;19:85 pubmed publisher
    ..Altogether, our data suggest that PDPN may play an important role in the control of invasion and migration of papillary thyroid carcinoma cells in association with the E/R/M, MMPs and MAPK kinases. ..
  17. O Connor J, Farach Carson M, Schneider C, Carson D. Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells. Mol Cancer Res. 2007;5:585-603 pubmed
    ..Collectively, these studies suggest that prostate cancer cells modulate TGF-beta responsiveness of bone marrow stroma as one means of facilitating their own growth in bone...
  18. Olivry T, Mayhew D, Paps J, Linder K, Peredo C, Rajpal D, et al. Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions. J Invest Dermatol. 2016;136:1961-1969 pubmed publisher
    ..of genes encoding proteases cathepsin S (CTSS), mast cell chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leukotriene-synthesis enzymes (ALOX5, ALOX5AP, and LTA4H)...
  19. Wu X, Li K, Xie M, Yu M, Tang S, Li Z, et al. Construction and protective immunogenicity of DNA vaccine pNMB0315 against Neisseria meningitidis serogroup B. Mol Med Rep. 2018;17:3178-3185 pubmed publisher
    ..meningitidis serogroup B (NMB) has been problematic. NMB0315 is an outer membrane protein of NMB that may be a virulence factor for N...
  20. Arbo M, Melega S, Stöber R, Schug M, Rempel E, Rahnenführer J, et al. Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis. Arch Toxicol. 2016;90:3045-3060 pubmed
    ..Additionally, glycoprotein transmembrane nmb, which participates in cell adhesion processes, and fatty acid desaturase 1, an enzyme that regulates unsaturation ..
  21. Harun Or Rashid M, Inman D. Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. J Neuroinflammation. 2018;15:313 pubmed publisher
    ..DBA/2J-Gpnmb+ (D2G) mice were also used as a non-pathological genetic control for the D2 mice...
  22. Ng W, Londrigan S, Nasr N, Cunningham A, Turville S, Brooks A, et al. The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. J Virol. 2016;90:206-21 pubmed publisher
    ..As langerin represented the sole receptor for IAV infection in this system, we have defined the pathways and compartments involved in infectious entry of IAV into cells following recognition by langerin. ..
  23. Hsu Y, Liu K, Yeh H, Lin H, Wu H, Tsai J. Sustained release of recombinant thrombomodulin from cross-linked gelatin/hyaluronic acid hydrogels potentiate wound healing in diabetic mice. Eur J Pharm Biopharm. 2019;135:61-71 pubmed publisher
    ..The developed rhTM hydrogels could meet the needs for clinical practice, and may have future medical applications for wound care in diabetic patients. ..
  24. Xu T, Li D, Wang H, Zheng T, Wang G, Xin Y. MUC1 downregulation inhibits non-small cell lung cancer progression in human cell lines. Exp Ther Med. 2017;14:4443-4447 pubmed publisher
    ..In conclusion, the findings indicated that silencing of MUC1 gene may inhibit the development of NSCLC cells...
  25. Gabaev I, Elbasani E, Ameres S, Steinbrück L, Stanton R, Döring M, et al. Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. J Virol. 2014;88:14326-39 pubmed publisher
    ..Surprisingly, CMV-expressed UL11 did not affect the activity of virus-specific CD8 T cells. This finding warrants investigation of the impact of UL11 on CD45 functions in other leukocyte subpopulations. ..
  26. Gonzalez G, Huang Q, Mashimo H. Characterization of oncocytes in deep esophageal glands. Dis Esophagus. 2016;29:670-80 pubmed publisher
    ..This transdifferentiation might lead to an overall decrease of mucins production and secretion by the dEG and a subsequent reduction of the protection conferred by the viscoelastic mucous layer. ..
  27. Kumar S, Lanckacker E, Dentener M, Bracke K, Provoost S, De Grove K, et al. Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent. PLoS ONE. 2016;11:e0151113 pubmed publisher
    ..Data from this murine model of concomitant exposure to CS and HDM might be of importance for smoking allergic asthmatics. ..
  28. Hsu Y, Shi G, Wang K, Ma C, Cheng T, Wu H. Thrombomodulin promotes focal adhesion kinase activation and contributes to angiogenesis by binding to fibronectin. Oncotarget. 2016;7:68122-68139 pubmed publisher
    ..In summary, TM promotes angiogenesis by enhancing cell adhesion, migration, and FAK activation through interaction with fibronectin. TM may represent a novel target for inhibiting tumor angiogenesis. ..
  29. Grinholc M, Rodziewicz A, Forys K, Rapacka Zdonczyk A, Kawiak A, Domachowska A, et al. Fine-tuning recA expression in Staphylococcus aureus for antimicrobial photoinactivation: importance of photo-induced DNA damage in the photoinactivation mechanism. Appl Microbiol Biotechnol. 2015;99:9161-76 pubmed publisher
    ..By using exogenous photosensitizers (new methylene blue (NMB), toluidine blue O (TBO), 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPyP), ..
  30. Simms A, Jacob R, Cohen C, Siddiqui M. TROP-2 expression in papillary thyroid carcinoma: Potential Diagnostic Utility. Diagn Cytopathol. 2016;44:26-31 pubmed publisher
    ..TROP-2 may play an important role in diagnosing classic PTC, especially in equivocal cases. This study also identifies a strong role for TROP-2 in separating PTC from BTN. ..
  31. Bhattacharya S, Yin J, Winborn C, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017;58:2366-2387 pubmed publisher
    ..Our results demonstrate that Prom1 plays a key role in the regulation of autophagy via upstream suppression of mTOR signaling and also acting as a component of a macromolecular scaffold involving p62 and HDAC6. ..
  32. Pollan S, Huang F, Sperger J, Lang J, Morrissey C, Cress A, et al. Regulation of inside-out β1-integrin activation by CDCP1. Oncogene. 2018;37:2817-2836 pubmed publisher
  33. Chen S, Hsieh T, Fan W, Lai C, Peng C. Does pharmacological activation of 5-HT1A receptors improve urine flow rate in female rats?. Am J Physiol Renal Physiol. 2016;311:F166-75 pubmed publisher
    ..the independent roles of urethral striated and smooth muscles in the UFR in rats after a neuromuscular blockade (NMB) treatment and bilateral hypogastric nerve transection...
  34. Chen T, Wang H, Liu Y, Zhao B, Zhao Y, Fan R, et al. Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes. Int J Mol Sci. 2016;17: pubmed
    ..By contrast, the level of glycoprotein non-metastatic melanoma protein b (GPNMB) was unaffected by OA1 overexpression...
  35. Mustapha M, Harrison L. Vaccine Prevention of Meningococcal Disease in Africa: Major Advances, Remaining Challenges. Hum Vaccin Immunother. 2017;: pubmed publisher
    ..Outside the meningitis belt, NmB predominates in North Africa, while NmW followed by NmB predominate in South Africa...
  36. Huber A, Tan D, Sun J, Dean D, Wu T, Zhou Z. High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7. BMC Gastroenterol. 2015;15:80 pubmed publisher
    ..High CA9 expression may be related to the acidic environment caused by gastroesophageal reflux disease in the gastroesophageal junction and associated with tumorigenesis through BMI1, MCM4 and MCM7. ..
  37. Han Y, An Y, Jia G, Wang X, He C, Ding Y, et al. Facile assembly of upconversion nanoparticle-based micelles for active targeted dual-mode imaging in pancreatic cancer. J Nanobiotechnology. 2018;16:7 pubmed publisher
  38. Saeidi B, Koralkar R, Griffin R, Halloran B, Ambalavanan N, Askenazi D. Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates. Pediatr Nephrol. 2015;30:2037-44 pubmed publisher
    ..Albumin was associated with sex only. Beta-2-microglbulin (B2M), osteoactivin, kidney injury molecule -1 (KIM-1), and alpha glutathione S-transferase (αGST) were associated with ..
  39. Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed publisher
    ..tb infected lungs. Our studies demonstrate that TF expressed by myeloid cells has newly recognized abilities to polarize macrophages and to regulate M. tb growth. ..
  40. Freire F, Ferraresi C, Jorge A, Hamblin M. Photodynamic therapy of oral Candida infection in a mouse model. J Photochem Photobiol B. 2016;159:161-8 pubmed publisher
    ..The phenothiazinium salts, methylene blue (MB) and new methylene blue (NMB) were used as photosensitizers (PS), combined or not with potassium iodide (KI), and red laser (660nm) at four ..
  41. Dong B, Somani A, Love P, Zheng X, Chen X, Zhang J. CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1. Int J Mol Med. 2016;38:45-56 pubmed publisher
    ..CD5 is not a SHP-1 substrate and SHP-1 is not required for and possibly not involved in the CD5-mediated modulation of TCR signaling. ..
  42. Taylor E, Pol Fachin L, Lins R, Lower S. Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding. Proteins. 2017;85:561-570 pubmed publisher
    ..The findings also support that EGF-EGFR binding takes place through a large-scale induced-fitting mechanism. Proteins 2017; 85:561-570. © 2016 Wiley Periodicals, Inc. ..
  43. Paton F, Paulden M, Chambers D, Heirs M, Duffy S, Hunter J, et al. Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation. Br J Anaesth. 2010;105:558-67 pubmed publisher
    ..and an economic assessment of sugammadex for the reversal of moderate or profound neuromuscular block (NMB) produced by rocuronium or vecuronium...
  44. Kramer G, Wegdam W, Donker Koopman W, Ottenhoff R, Gaspar P, Verhoek M, et al. Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models. FEBS Open Bio. 2016;6:902-13 pubmed publisher
    ..Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB)...
  45. Rose A, Biondini M, Curiel R, Siegel P. Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer. Pharmacol Ther. 2017;179:127-141 pubmed publisher
    b>GPNMB has emerged as an immunomodulator and an important positive mediator of tumor progression and metastasis in numerous solid cancers...
  46. Maybin J, Boswell L, Young V, Duncan W, Critchley H. Reduced Transforming Growth Factor-? Activity in the Endometrium of Women With Heavy Menstrual Bleeding. J Clin Endocrinol Metab. 2017;102:1299-1308 pubmed publisher
    ..from women, and menstrual blood loss objectively measured [HMB >80 mL/cycle; normal menstrual bleeding (NMB) <80 mL]...
  47. Zhang X, Wu L, Xiao T, Tang L, Jia X, Guo Y, et al. TRAF6 regulates EGF-induced cell transformation and cSCC malignant phenotype through CD147/EGFR. Oncogenesis. 2018;7:17 pubmed publisher
    ..Our results showed that CD147 formed complex with EGFR and TRAF6. Knockdown of TRAF6 disrupted the CD147-EGFR complex, thereby inducing EGFR endocytosis. Therefore, TRAF6 might be a novel molecular target for cSCC prevention or therapy. ..
  48. Cao M, Gao J, Zhou H, Huang J, You A, Guo Z, et al. HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma. Tumour Biol. 2016;37:1651-62 pubmed publisher
    ..Taken together, these data demonstrated that HIF-2α could promote HCC cell migration by regulating CDCP1, and targeting HIF-2α-CDCP1-PKCδ pathway might be effective to inhibit HCC metastasis. ..
  49. Sasaki F, Kumagai K, Uto H, Takami Y, Kure T, Tabu K, et al. Expression of glycoprotein nonmetastatic melanoma protein B in macrophages infiltrating injured mucosa is associated with the severity of experimental colitis in mice. Mol Med Rep. 2015;12:7503-11 pubmed publisher
    b>Glycoprotein nonmetastatic melanoma protein B (Gpnmb) is a transmembrane glycoprotein, which negatively regulates the inflammatory responses of macrophages...
  50. Pham Q, Oue N, Yamamoto Y, Shigematsu Y, Sekino Y, Sakamoto N, et al. The Expression of BTS-2 Enhances Cell Growth and Invasiveness in Renal Cell Carcinoma. Anticancer Res. 2017;37:2853-2860 pubmed
    ..These results suggest that BST2 plays an important role in the progression of RCC. Because BST2 is expressed on the cell membrane, BST2 is a good therapeutic target for RCC. ..
  51. Trippoli S, Caccese E, Marinai C, Messori A. Value-based procurement of medical devices: Application to devices for mechanical thrombectomy in ischemic stroke. Clin Neurol Neurosurg. 2018;166:61-65 pubmed publisher
    ..As regards economic modeling, we firstly estimated for each device the net monetary benefit (NMB) per patient (threshold = $60,000 per QALY); then, we simulated a competitive tender across the four products ..
  52. Li J, Huang Q, Long X, Zhang J, Huang X, Aa J, et al. CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways. J Hepatol. 2015;63:1378-89 pubmed publisher
    ..Our findings demonstrate that CD147 is a critical regulator of fatty acid metabolism, which provides a strong line of evidence for this molecule to be used as a drug target in cancer treatment. ..
  53. Maru S, Byrnes J, Carrington M, Chan Y, Thompson D, Stewart S, et al. Cost-effectiveness of home versus clinic-based management of chronic heart failure: Extended follow-up of a pragmatic, multicentre randomized trial cohort - The WHICH? study (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Frie. Int J Cardiol. 2015;201:368-75 pubmed publisher
    ..Cost-effectiveness acceptability curves were constructed based on incremental net monetary benefit (NMB). We performed multiple linear regression to explore which patient characteristics may impact patient-level NMB...
  54. Xu Z, Liu Y, Yang Y, Wang J, Zhang G, Liu Z, et al. High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma. Oncotarget. 2017;8:7548-7558 pubmed publisher
    ..MUC13 high expression is a novel independent adverse prognostic factor of clinical outcome in non-metastatic ccRCC patients after surgery. ..
  55. Im S, Lee K, Nam E, Kim D, Lee J, Han H, et al. Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas. Tumori. 2005;91:513-21 pubmed
    ..The authors investigated the correlation between clinicopathologic variables including survival and the overexpression of the p185(HER2) with loss of PTEN expression in gastric adenocarcinoma patients...
  56. Kim J, Badawi M, Park J, Jiang J, Mo X, Roberts L, et al. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016;49:2037-2045 pubmed publisher
    ..We report that CD151 is a target of miR-199a-3p and that increased CD151 protein resulting from reduced miR-199a-3p could contribute to the development of metastatic HCC. ..
  57. Pühringer F, Gordon M, Demeyer I, Sparr H, Ingimarsson J, Klarin B, et al. Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose-response relationship. Br J Anaesth. 2010;105:610-9 pubmed publisher
    Sugammadex shows a dose-response relationship for reversal of neuromuscular block (NMB) during propofol anaesthesia. Sevoflurane, unlike propofol, can prolong the effect of neuromuscular blocking agents (NMBAs), increasing recovery time...
  58. Du W, Yuan Y, Wang L, Cui Y, Wang H, Xu H, et al. Multifunctional Bioconjugate for Cancer Cell-Targeted Theranostics. Bioconjug Chem. 2015;26:2571-8 pubmed publisher
    ..A cytotoxicity study indicated that Vehicle-DOX could be applied for MUC1-targeted cytotoxicity. We anticipate that our multifunctional bioconjugate Vehicle-DOX could be applied for in vivo tumor-targeted theranostics. ..
  59. Tong H, Jiang G, Qi D, Bi J, Tian D, Guan X, et al. Bupleurum chinense polysaccharide inhibit adhesion of human melanoma cells via blocking ?1 integrin function. Carbohydr Polym. 2017;156:244-252 pubmed publisher
    ..Collectively, our current findings indicated that BCP may be a potential therapy for melanoma metastasis due to its inhibitory effects on integrin function. ..
  60. Veiga Ruiz G, García Cayuela J, Orozco Montes J, Parreño Caparrós M, Garcia Rojo B, Aguayo Albasini J. Monitoring intraoperative neuromuscular blockade and blood pressure with one device (TOF-Cuff): A comparative study with mechanomyography and invasive blood pressure. Rev Esp Anestesiol Reanim. 2017;64:560-567 pubmed publisher monitor with the same device the non-invasive blood pressure (NIBP) and the depth of a neuromuscular blockade (NMB) induced pharmacologically, by stimulation of the brachial plexus at the humeral level and recording evoked changes ..
  61. Madsen M, Scheppan S, Kissmeyer P, Mørk E, Rosenberg J, Gätke M. Neuromuscular blockade for improvement of surgical conditions during laparotomy: protocol for a randomised study. Dan Med J. 2015;62:A5139 pubmed
    ..Establishment of a deep neuromuscular blockade (NMB), defined as a post-tetanic-count (PTC) of 0-1, paralyses the abdominal wall muscles and the diaphragm...
  62. Julián M, Alonso N, Colobran R, Sánchez A, Miñarro A, Pujol Autonell I, et al. CD26/DPPIV inhibition alters the expression of immune response-related genes in the thymi of NOD mice. Mol Cell Endocrinol. 2016;426:101-12 pubmed publisher
  63. Hu X, Zhang P, Xu Z, Chen H, Xie X. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem. 2013;114:2729-37 pubmed publisher
    ..Glycoprotein non-metastatic melanoma protein B (GPNMB) is known to be vital in bone formation...
  64. Nam K, Oh S, Shin I. Ablation of CD44 induces glycolysis-to-oxidative phosphorylation transition via modulation of the c-Src-Akt-LKB1-AMPK? pathway. Biochem J. 2016;473:3013-30 pubmed publisher
    ..Collectively, these results indicate that the CD44 silencing-induced metabolic shift is mediated by the regulation of c-Src/Akt/LKB1/AMPK?/HIF-1? signaling in human breast cancer cells. ..
  65. Wang F, Guan B, Yang J, Wang H, Zhou C. CEACAM1 is overexpressed in oral tumors and related to tumorigenesis. Med Mol Morphol. 2017;50:42-51 pubmed publisher
    ..05). So, we thought oral tumors overexpressed CEACAM1 and the cytoplasmic CEACAM1 might be involved in tumorigenesis, and also CEACAM1 might be regarded as a marker of salivary glandular tumors. ..
  66. Sondag G, Mbimba T, Moussa F, Novak K, Yu B, Jaber F, et al. Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling. Exp Mol Med. 2016;48:e257 pubmed publisher
    b>Osteoactivin is a heavily glycosylated protein shown to have a role in bone remodeling. Previous studies from our lab have shown that mutation in Osteoactivin enhances osteoclast differentiation but inhibits their function...
  67. Staines K, Javaheri B, Hohenstein P, Fleming R, Ikpegbu E, Unger E, et al. Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. J Cell Physiol. 2017;232:3006-3019 pubmed publisher
    ..As the osteocyte dendritic network is known to play vital roles in regulating bone modeling/remodeling, this highlights an essential role for Pdpn in bone homeostasis. ..
  68. Konnopka A, Konig H, Kaufmann C, Egger N, Wild B, Szecsenyi J, et al. Cost-utility of a specific collaborative group intervention for patients with functional somatic syndromes. J Psychosom Res. 2016;90:43-50 pubmed publisher
    ..We calculated patients' net-monetary-benefit (NMB), estimated the treatment effect via regression, and generated cost-effectiveness acceptability curves...
  69. Setua S, Khan S, Yallapu M, Behrman S, Sikander M, Khan S, et al. Restitution of Tumor Suppressor MicroRNA-145 Using Magnetic Nanoformulation for Pancreatic Cancer Therapy. J Gastrointest Surg. 2017;21:94-105 pubmed publisher
    ..miR-145-MNPF is an efficient system for miR-145 delivery and restitution in pancreas cancer that may offer a potential therapeutic treatment for PC either alone or in conjunction with conventional treatment. ..
  70. Satoh K. Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research. Circ J. 2017;81:1557-1563 pubmed publisher
    ..Ultimately, the final goal is to develop novel biomarkers and medications that will be useful for improving the prognosis and quality of life in patients with cardiovascular diseases...
  71. Liu Y, Tolbert E, Sun A, Dworkin L. Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells. Am J Physiol. 1996;271:F679-88 pubmed
  72. Prizant H, Taya M, Lerman I, Light A, Sen A, Mitra S, et al. Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model. Endocr Relat Cancer. 2016;23:265-80 pubmed publisher
    ..Finally, we identify glycoprotein NMB (GPNMB) as a melanocytic marker up-regulated in Tsc2-null mouse uteri and human LAM samples...
  73. Ashkenazi S, Ortenberg R, Besser M, Schachter J, Markel G. SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells. Oncotarget. 2016;7:30166-77 pubmed publisher
    ..As CEACAM1 is a pivotal protein in melanoma biology and immune crosstalk, further understanding of its regulation can provide new insights and contribute to the development of novel approaches to therapy. ..
  74. Rose A, Annis M, Frederick D, Biondini M, Dong Z, Kwong L, et al. MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB. Clin Cancer Res. 2016;22:6088-6098 pubmed
    To determine if BRAF and/or MEK inhibitor-induced GPNMB expression renders melanomas sensitive to CDX-011, an antibody-drug conjugate targeting GPNMB...
  75. Weng X, Monteiro A, Guo J, Ahmed B, Bernard J, Tomlinson D, et al. Short communication: Repeated mammary tissue collections during lactation do not alter subsequent milk yield or composition. J Dairy Sci. 2017;100:8422-8425 pubmed publisher
    ..The MB and non-MB (NMB) cows had similar parity (2.6 ± 0.9) and days in milk (96.5 ± 56.3 d) at enrollment...
  76. Son S, Shin S, Rao N, Um W, Jeon J, Ko H, et al. Anti-Trop2 antibody-conjugated bioreducible nanoparticles for targeted triple negative breast cancer therapy. Int J Biol Macromol. 2018;110:406-415 pubmed publisher
    ..Overall, ST-NPs might be a promising carrier of DOX for targeted TNBC therapy. ..
  77. Joyeux L, Deprez M, Khatoun A, van Kuyck K, Pelsmaekers K, Engels A, et al. Quantitative analysis of motor evoked potentials in the neonatal lamb. Sci Rep. 2017;7:16095 pubmed publisher
    ..MEPs were also measured in one lamb undergoing Neuro-Muscular Blockade (NMB) and another undergoing lumbar spinal cord (SC) transection, both serving as controls...
  78. Bandari P, Qian J, Yehia G, Joshi D, Maloof P, Potian J, et al. Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P. Regul Pept. 2003;111:169-78 pubmed
    ..Based on its expression, the cDNA clone was designated hematopoietic growth factor inducible neurokinin-1 type (HGFIN). Computational analyses predicted that HGFIN is transmembrane with the carboxyl terminal extracellular...
  79. Ono Y, Chiba S, Yano H, Nakayama N, Saio M, Tsuruma K, et al. Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase. Biochem Biophys Res Commun. 2016;481:7-12 pubmed publisher
    b>Glycoprotein nonmetastatic melanoma protein B (GPNMB), which is involved in invasion and metastasis, was found to be overexpressed in various cancers...
  80. Barrio J, Errando C, García Ramón J, Sellés R, San Miguel G, Gallego J. Influence of depth of neuromuscular blockade on surgical conditions during low-pressure pneumoperitoneum laparoscopic cholecystectomy: A randomized blinded study. J Clin Anesth. 2017;42:26-30 pubmed publisher
    To evaluate the influence of neuromuscular blockade (NMB) on surgical conditions during low-pressure pneumoperitoneum (8mmHg) laparoscopic cholecystectomy (LC), while comparing moderate and deep NMB...
  81. Zhuo H, Zhou L. Gpnmb/osteoactivin: an indicator and therapeutic target in tumor and nontumorous lesions. Pharmazie. 2016;71:555-561 pubmed publisher
    Non-metastatic melanoma glycoprotein B (Gpnmb), a type I transmembrane glycoprotein, was first cloned and described in low-metastatic human melanoma and xenografts in 1995...
  82. Chen Y, Hsu H, Chen Y, Tsai T, How C, Wang C, et al. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS ONE. 2008;3:e2637 pubmed publisher
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  83. Zhang P, Liu W, Zhu C, Yuan X, Li D, Gu W, et al. Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashion. PLoS ONE. 2012;7:e42955 pubmed publisher
    ..Glycoprotein (transmembrane) non-metastatic melanoma protein b (GPNMB), a melanosome-specific structural protein, shares significant amino acid sequence homology with Pmel-17...
  84. Arosarena O, DeLa Cadena R, Denny M, Bryant E, Barr E, Thorpe R, et al. Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas. J Cell Physiol. 2016;231:1761-70 pubmed publisher
    ..Metastasis is mediated by cancer cell adhesion, migration, and invasion. Osteoactivin (OA) overexpression plays a role in metastases in several malignancies...
  85. Kisserli A, Tabary T, Cohen J, Duret V, Mahmoudi R. High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment. J Vis Exp. 2017;: pubmed publisher
    ..Thus, the use of this method should be helpful to better understand the role of CR1 isoforms in the pathogenesis of diseases such as AD. ..
  86. Rezonja K, Mars T, Jerin A, Kozelj G, Pozar Lukanovic N, Sostaric M. Dexamethasone does not diminish sugammadex reversal of neuromuscular block - clinical study in surgical patients undergoing general anesthesia. BMC Anesthesiol. 2016;16:101 pubmed
    Sugammadex reverses neuromuscular block (NMB) through binding aminosteroid neuromuscular blocking agents. Although sugammadex appears to be highly selective, it can interact with other drugs, like corticosteroids...
  87. Lu I, Chang P, Su M, Chen P, Chen H, Chiang F, et al. The feasibility of sugammadex for general anesthesia and facial nerve monitoring in patients undergoing parotid surgery. Kaohsiung J Med Sci. 2017;33:400-404 pubmed publisher
    ..Sugammadex has been reported to be an effective and safe reversal of rocuronium-induced neuromuscular block (NMB) during surgery...
  88. Brown T, Szabo T, Bridges K, Sabbagh M, Hand W, Wolf B, et al. Safety and Effectiveness of a Novel Facemask for Positive Pressure Ventilation. Anesth Analg. 2017;: pubmed publisher
    ..The purpose of this study was to evaluate the safety and effectiveness of the Tao mask compared to a standard mask before and after the administration of neuromuscular blockade (NMB) using 2 previously established ventilation scales.
  89. Prystaz K, Kaiser K, Kovtun A, Haffner Luntzer M, Fischer V, Rapp A, et al. Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. Am J Pathol. 2018;188:474-490 pubmed publisher
    ..Our results reveal that IL-6 classic signaling, but not IL-6 trans-signaling, is essential for bone repair. ..
  90. Metz R, Patel P, Hameed M, Bryan M, Rameshwar P. Role of human HGFIN/nmb in breast cancer. Breast Cancer Res. 2007;9:R58 pubmed
    HGFIN, previously identified as nmb, and its homolog osteoactivin are single transmembrane proteins that are expressed in differentiated immune cells...
  91. Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS ONE. 2015;10:e0116644 pubmed publisher
    ..Apart from the M1/M2 gene analysis, we demonstrate that the expression of Gpnmb and Spp1 is highly upregulated in both murine and human glioma-associated microglia/macrophages...
  92. Murthy M, Blauwendraat C, Guelfi S, Hardy J, Lewis P, Trabzuni D. Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3. Neurogenetics. 2017;18:121-133 pubmed publisher
    ..3, initially designated as the glycoprotein non-metastatic melanoma protein B (GPNMB) locus...