GPD1L

Summary

Gene Symbol: GPD1L
Description: glycerol-3-phosphate dehydrogenase 1-like
Alias: GPD1-L, glycerol-3-phosphate dehydrogenase 1-like protein
Species: human

Top Publications

  1. pmc A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
    Timothy J Kelly
    Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 31:2696-706. 2011
  2. pmc Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:2260-8. 2007
  3. ncbi Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome
    Takeru Makiyama
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 72:1705-6. 2008
  4. pmc Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome
    David W Van Norstrand
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 116:2253-9. 2007
  5. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
  6. pmc An integrated approach for experimental target identification of hypoxia-induced miR-210
    Pasquale Fasanaro
    IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy
    J Biol Chem 284:35134-43. 2009
  7. pmc Cardiac Na+ current regulation by pyridine nucleotides
    Man Liu
    Division in Cardiology, University of Illinois at Chicago and the Jesse Brown Veteran Affairs Medical Center, Chicago, IL 60612, USA
    Circ Res 105:737-45. 2009
  8. pmc GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A
    Carmen R Valdivia
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 297:H1446-52. 2009
  9. doi Scriptaid corrects gene expression of a few aberrantly reprogrammed transcripts in nuclear transfer pig blastocyst stage embryos
    Kristin M Whitworth
    Division of Animal Sciences, University of Missouri, E125 Animal Science Research Center, Columbia, USA
    Cell Reprogram 13:191-204. 2011
  10. doi The genetic basis of Brugada syndrome: a mutation update
    Paula L Hedley
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Hum Mutat 30:1256-66. 2009

Scientific Experts

  • Barry London
  • Konstantinos Dean Boudoulas
  • Jonathan C Makielski
  • Jonathan Makielski
  • Carmen R Valdivia
  • Michael J Ackerman
  • Josef Frank
  • Timothy J Kelly
  • Kristin M Whitworth
  • Shawn K Westaway
  • Man Liu
  • Pasquale Fasanaro
  • Paula L Hedley
  • Kazuo Ueda
  • Takeru Makiyama
  • David W Van Norstrand
  • Christine Schmäl
  • Jens Treutlein
  • Michael Steffens
  • Norbert Scherbaum
  • Marcus Ising
  • Monika Ridinger
  • Wolfgang Maier
  • Per Hoffmann
  • Michael Soyka
  • Falk Kiefer
  • Markus M Nothen
  • Peter Zill
  • Sven Cichon
  • Bertram Muller-Myhsok
  • Norbert Wodarz
  • Marcella Rietschel
  • Rainald Mossner
  • Wolfgang Gaebel
  • Manuel Mattheisen
  • Stefan Herms
  • Norbert Dahmen
  • Susanne Lucae
  • Karl Mann
  • Adriana Huertas-Vazquez
  • Kyndaron Reinier
  • Audrey Evanado
  • Amanda L Souza
  • Stefan Kaab
  • Carmen Teodorescu
  • Randall S Prather
  • Jo Navarro
  • Jiangou Zhao
  • Lee D Spate
  • Sumeet S Chugh
  • Karen Gunson
  • Jonathan Jui
  • Clary B Clish
  • Moritz F Sinner
  • Pere Puigserver
  • Peter Spooner
  • Rongfeng Li
  • Bin Ye
  • Timothy J Algiers
  • Argelia Medeiros-Domingo
  • Win Kuang Shen
  • Lijuan L Shang
  • Samuel C Dudley
  • Mario Pescatori
  • Laurie J Kerchner
  • Poul Jørgensen
  • Maurizio C Capogrossi
  • Georgia Gaconnet
  • Ge Gao
  • Shamarendra Sanyal
  • Simona Greco
  • Sarah Schlamowitz
  • Andrew Grace
  • Maura Brioschi
  • Iman S Gurung
  • Ritu Kulshreshtha
  • Andrew Stubbs
  • Xiaodong Zhu
  • Michael Christiansen
  • Jørgen K Kanters
  • Maria Lorenzi
  • Mircea Ivan
  • George A Calin
  • Christopher L H Huang
  • Cristina Banfi
  • Johanna Moolman-Smook
  • Valerie A Corfield
  • Fabio Martelli
  • Masaharu Akao
  • Seiko Ohno

Detail Information

Publications15

  1. pmc A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
    Timothy J Kelly
    Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 31:2696-706. 2011
    ..Here, we identify the enzyme glycerol-3-phosphate dehydrogenase 1-like (GPD1L) as a novel regulator of HIF-1α stability and a direct target of miR-210...
  2. pmc Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:2260-8. 2007
    ..We previously used positional cloning to identify a new locus on chromosome 3p24 in a large family with Brugada syndrome and excluded SCN5A as a candidate gene...
  3. ncbi Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome
    Takeru Makiyama
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 72:1705-6. 2008
    ..A novel causative gene (glycerol-3 phosphate dehydrogenase-1 like; GPD1L) has been reported, and in the present study, 80 unrelated Japanese patients were screened for GPD1L mutations: 1 ..
  4. pmc Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome
    David W Van Norstrand
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 116:2253-9. 2007
    ..We hypothesized that mutations in GPD1-L may be responsible for some cases of sudden unexplained death/sudden infant death syndrome...
  5. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
    ..The latter result may indicate that many more AD susceptibility genes still await identification...
  6. pmc An integrated approach for experimental target identification of hypoxia-induced miR-210
    Pasquale Fasanaro
    IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy
    J Biol Chem 284:35134-43. 2009
    ..The complex was significantly enriched in mRNAs of 31 candidate targets, such as BDNF, GPD1L, ISCU, NCAM, and the non-coding RNA Xist...
  7. pmc Cardiac Na+ current regulation by pyridine nucleotides
    Man Liu
    Division in Cardiology, University of Illinois at Chicago and the Jesse Brown Veteran Affairs Medical Center, Chicago, IL 60612, USA
    Circ Res 105:737-45. 2009
    ..GPD1-L has >80% amino acid homology with glycerol-3-phosphate dehydrogenase, which is involved in NAD-dependent energy metabolism...
  8. pmc GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A
    Carmen R Valdivia
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    Am J Physiol Heart Circ Physiol 297:H1446-52. 2009
    ..The gene GPD1L encodes the glycerol phosphate dehydrogenase 1-like protein with homology to glycerol phosphate dehydrogenase (..
  9. doi Scriptaid corrects gene expression of a few aberrantly reprogrammed transcripts in nuclear transfer pig blastocyst stage embryos
    Kristin M Whitworth
    Division of Animal Sciences, University of Missouri, E125 Animal Science Research Center, Columbia, USA
    Cell Reprogram 13:191-204. 2011
    ..Scriptaid treatment resulted high expression of COX5A and very low expression of GPD1L, EIF3E, and GSTA3...
  10. doi The genetic basis of Brugada syndrome: a mutation update
    Paula L Hedley
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Hum Mutat 30:1256-66. 2009
    ..A few mutations have been described in GPD1L, which encodes glycerol-3-phosphate dehydrogenase-1 like protein; CACNA1C, which encodes the alpha-subunit of the ..
  11. doi Beyond membrane channelopathies: alternative mechanisms underlying complex human disease
    Konstantinos Dean Boudoulas
    The Dorothy M Davis Heart and Lung Research Institute, Ohio State University Medical Center, Columbus, OH 43210, USA
    Acta Pharmacol Sin 32:798-804. 2011
    ..coat proteins including caveolin-3 (CAV3), signaling platforms including yotiao (AKAP9), and cardiac enzymes (GPD1L)...
  12. pmc Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease
    Shawn K Westaway
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Circ Cardiovasc Genet 4:397-402. 2011
    ..We conducted a systematic candidate-gene approach using haplotype-tagging single nucleotide polymorphisms (htSNPs) to identify genes associated with SCD risk in the context of CAD...
  13. pmc Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation
    Carmen R Valdivia
    Department of Medicine, Cardiovascular Section, and the Cardiac Molecular Arrhythmias Research Program, University of Wisconsin Madison, 600 Highland Avenue H6 349, Madison, WI 53792, USA
    Cardiovasc Res 86:392-400. 2010
    ..5 is regulated by four sodium channel auxiliary beta subunits. Here, we report a case with IVF and a novel mutation in the SCN3B-encoded sodium channel beta subunit Navbeta3 that causes a loss of function of Nav1.5 channels in vitro...

Research Grants26

  1. Cellular and clinical phenotypes of novel SCN5a mutations
    Jonathan C Makielski; Fiscal Year: 2010
    ..From patients in these cohorts we have recently discovered mutations in putative ChIPs (CAV3, SNTA1, GPD1L, SCN4B) and shown that they affect INa in a way that may be pathogenic...
  2. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2005
    ..abstract_text> ..
  3. Genetic Modulators of Sudden Death
    Barry London; Fiscal Year: 2007
    ..We hope to identify genetic predictors for the common forms of sudden cardiac death. This would allow the identification of a subpopulation of heart failure patients that would benefit most from ICD placement. ..
  4. A Clinical and Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2009
    ..In this proposal, we will study a family with an inherited genetic form of sudden death with the hope that we can develop new treatments for the more common causes of this devastating and unpredictable condition. ..
  5. A Clinical and Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2010
    ..In this proposal, we will study a family with an inherited genetic form of sudden death with the hope that we can develop new treatments for the more common causes of this devastating and unpredictable condition. ..
  6. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2003
    ....
  7. CLINICAL AND MOLECULAR ANALYSIS OF THE BRUGADA SYNDROME
    Barry London; Fiscal Year: 2001
    ..abstract_text> ..
  8. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2002
    ..Information gained from these studies may help to clarify the mechanisms of the more common arrhythmias that cause sudden death. ..
  9. CYTOKINE-INDUCED ARRHYTHMIAS IN CONGESTIVE HEART FAILURE
    Barry London; Fiscal Year: 2004
    ....