Gene Symbol: GPC5
Description: glypican 5
Alias: glypican-5, bA93M14.1, glypican proteoglycan 5
Species: human
Products:     GPC5

Top Publications

  1. Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G. Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family. Genomics. 1997;40:24-30 pubmed
    ..The gene for this novel glypican (GPC5) maps to 13q32. In the adult, it is primarily expressed in brain tissue.
  2. Saunders S, Paine Saunders S, Lander A. Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997;190:78-93 pubmed
  3. Okamoto K, Tokunaga K, Doi K, Fujita T, Suzuki H, Katoh T, et al. Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat Genet. 2011;43:459-63 pubmed publisher
    ..Here we identify an association between variants in GPC5, encoding glypican-5, and acquired nephrotic syndrome through a genome-wide association study and replication ..
  4. Arking D, Reinier K, Post W, Jui J, Hilton G, O Connor A, et al. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. PLoS ONE. 2010;5:e9879 pubmed publisher
    ..The minor allele of GPC5 (GLYPICAN 5, rs3864180) was associated with a lower risk of SCA in Oregon-SUDS, an effect that was also observed in ARIC/CHS ..
  5. Li Y, Sheu C, Ye Y, de Andrade M, Wang L, Chang S, et al. Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol. 2010;11:321-30 pubmed publisher
    ..there was a strong correlation between genotypes of the replicated SNPs and the transcription level of the gene GPC5 in normal lung tissues (p=1.96x10(-4)), with the high-risk allele linked with lower expression...
  6. Johnson B, Wang J, Taylor E, Caillier S, Herbert J, Khan O, et al. Multiple sclerosis susceptibility alleles in African Americans. Genes Immun. 2010;11:343-50 pubmed publisher
    ..CD6, CLEC16a, EVI5, GPC5, and TYK2 contained SNPs that are associated with MS risk in the African American data set...
  7. Quelin C, Bendavid C, Dubourg C, de la Rochebrochard C, Lucas J, Henry C, et al. Twelve new patients with 13q deletion syndrome: genotype-phenotype analyses in progress. Eur J Med Genet. 2009;52:41-6 pubmed publisher
    ..1 is implicated in lens cell proliferation and differentiation for congenital cataract; GPC5 in 13q32 is mainly expressed in the mesenchyme of the developing limb bud for upper limb anomalies.
  8. Hong X, Zhang Z, Pan L, Ma W, Zhai X, Gu C, et al. MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5. Eur J Pharmacol. 2019;854:39-47 pubmed publisher
    Accumulating evidence has suggested that Glypican-5 (GPC5) is a tumor suppressor gene in many types of cancers. However, whether GPC5 is involved in glioma remains unknown...
  9. Chorazy M, Wawrusiewicz Kurylonek N, Posmyk R, Zajkowska A, Kapica Topczewska K, Krętowski A, et al. Analysis of chosen SNVs in GPC5, CD58 and IRF8 genes in multiple sclerosis patients. Adv Med Sci. 2019;64:230-234 pubmed publisher
    ..The main aim of our study was to evaluate the association between selected polymorphisms of theCD58, IRF8 and GPC5 genes and treatment effectiveness in a group of relapsing-remitting MS patients...

More Information


  1. Bleich A, Hopf S, Hedrich H, van Lith H, Li F, Balfour Sartor R, et al. Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD. Inflamm Bowel Dis. 2009;15:1794-802 pubmed publisher
    ..Possible candidate genes within these QTL (including Tnfrsf11a/RANK, Gpc5, Il2ra, and Nfrkb) are also implicated in the respective human diseases.
  2. Yang C, Wang Y, Xu W, Liu Z, Zhou S, Zhang M, et al. Genome-wide association study using diversity outcross mice identified candidate genes of pancreatic cancer. Genomics. 2018;: pubmed publisher
    ..37 × 10-6) were identified, i.e., Epha4, Gpc5, Kcnj6, Arid1b...
  3. Earle N, Poppe K, Pilbrow A, Cameron V, Troughton R, Skinner J, et al. Genetic markers of repolarization and arrhythmic events after acute coronary syndromes. Am Heart J. 2015;169:579-86.e3 pubmed publisher
    ..3%). Three SNPs from 3 genes (rs17779747 [KCNJ2], rs876188 [C14orf64], rs3864180 [GPC5]) were significantly associated with SCD/CA in multivariable models (after correction for multiple testing); the ..
  4. Dong X, He X, Guan A, Huang W, Jia H, Huang Y, et al. Long non-coding RNA Hotair promotes gastric cancer progression via miR-217-GPC5 axis. Life Sci. 2019;217:271-282 pubmed publisher
    ..Hotair promoted GC development by promoting GCP5 expression via sponging miR-217. Hotair could serve as a potentially prognostic indicator and provide new light into its underlying biological-molecular mechanism in GC. ..
  5. Kameyama H, Uchimura K, Yamashita T, Kuwabara K, Mizuguchi M, Hung S, et al. The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity. Am J Pathol. 2019;189:308-319 pubmed publisher
    ..Furthermore, glypican-5, encoded by the susceptibility gene for nephrotic syndrome GPC5, was found to be accumulated in the transthyretin amyloidosis kidney...
  6. Okamoto K, Honda K, Doi K, Ishizu T, Katagiri D, Wada T, et al. Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney. Am J Pathol. 2015;185:1889-98 pubmed publisher
    ..We recently identified the gene for glypican-5 (GPC5), a cell-surface heparan sulfate proteoglycan, as conferring susceptibility for acquired nephrotic syndrome and ..
  7. Jacquet S, Pons J, De Bernardo A, Ngoubangoye B, Cosset F, Regis C, et al. Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats. J Virol. 2019;93: pubmed publisher
    ..Here, we determined the evolutionary history of the HBV receptors NTCP and GPC5 over millions of years of primate, rodent, and bat evolution...
  8. Sun Y, Xu K, He M, Fan G, Lü H. Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling. Oncol Res. 2018;26:565-572 pubmed publisher
    b>Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a regulator of growth factors and morphogens...
  9. Farnedi A, Rossi S, Bertani N, Gulli M, Silini E, Mucignat M, et al. Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors. BMC Cancer. 2015;15:352 pubmed publisher
    ..characterized by a variable expression of all PGs and a characteristic de novo transcription/translation of GPC2, GPC5 and NG2/CSPG4 respectively in 36%, 72% and 71% on 119 cases...
  10. Lacey C, Doudney K, Bridgman P, George P, Mulder R, Zarifeh J, et al. Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy. Sci Rep. 2018;8:7548 pubmed publisher
    ..Several of these CNVs impacted on genes of cardiac relevance including RBFOX1, GPC5, KCNRG, CHODL, and GPBP1L1...
  11. Takeuchi M, Higashino A, Takeuchi K, Hori Y, Koshiba Takeuchi K, Makino H, et al. Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. PLoS ONE. 2015;10:e0126562 pubmed publisher
    ..In particular, glypican-5 (GPC5), which encodes a cell-surface proteoglycan that might be a biomarker for sarcoma, was expressed at high levels in ..
  12. Magi R, Suleimanov Y, Clarke G, Kaakinen M, Fischer K, Prokopenko I, et al. SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics. 2017;18:25 pubmed publisher
    ..meta-analysis also revealed a novel signal of association at genome-wide significance for triglycerides mapping to GPC5 (lead SNP rs71427535, p?=?1...
  13. Wang H, Dong X, Gu X, Qin R, Jia H, Gao J. The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5. PLoS ONE. 2015;10:e0125474 pubmed publisher
    ..Enforced expression of miR-217 inhibited GC cells proliferation and invasion. Moreover, Glypican-5 (GPC5), a new ocncogene, was identified as the potential target of miR-217...
  14. Zhang H, Wang G, Yang X, Qiu M, Xu L. [Investigation of Gene Expression Profile of A549 Cells after Overexpression of GPC5 ?by High Throughput Transcriptome Sequencing]. Zhongguo Fei Ai Za Zhi. 2016;19:545-9 pubmed publisher
    Glypican-5 (GPC5) is an important tumor suppressor, while little is known about the impact of GPC5 on proliferation ability and gene expression in lung adenocarcinoma cell lines...
  15. Guo L, Wang J, Zhang T, Yang Y. Glypican-5 is a tumor suppressor in non-small cell lung cancer cells. Biochem Biophys Rep. 2016;6:108-112 pubmed
    Glypican-5 (GPC5) belongs to the glypican family of proteoglycans that have been implicated in a variety of physiological processes, ranging from cell proliferation to morphogenesis...
  16. Cleynen I, Mahachie John J, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, et al. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE. 2010;5:e12952 pubmed publisher
    ..The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine. ..
  17. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..We show that a genetic risk profile can be constructed that is clinically useful and that can aid in making treatment decisions. ..
  18. Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, et al. FGFR2 is associated with hair thickness in Asian populations. J Hum Genet. 2009;54:461-5 pubmed publisher
    ..0270). These results suggest that the FGFR2 polymorphism affects the variation in hair thickness in Asia through alteration in the expression level of FGFR2. ..
  19. Landi M, Chatterjee N, Caporaso N, Rotunno M, Albanes D, Thun M, et al. GPC5 rs2352028 variant and risk of lung cancer in never smokers. Lancet Oncol. 2010;11:714-6; author reply 716 pubmed publisher
  20. Yuan Q, Zhang Y, Li J, Cao G, Yang W. High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5. Biochem Biophys Res Commun. 2018;497:73-79 pubmed publisher
    A growing amount of evidence has documented that Glypican-5 (GPC5) is an important regulator of tumor progression. However, little is known about the role of GPC5 in pancreatic ductal adenocarcinoma (PDAC)...
  21. Sellebjerg F, Søndergaard H, Koch Henriksen N, Sørensen P, Oturai A. Prediction of response to interferon therapy in multiple sclerosis. Acta Neurol Scand. 2014;130:268-75 pubmed publisher
    ..nucleotide polymorphisms (SNPs) in the genes encoding interferon response factor (IRF)-5, IRF-8 and glypican-5 (GPC5) have been associated with disease activity in multiple sclerosis (MS) patients treated with interferon (IFN)-?...
  22. Zhang C, Liu Z, Wang L, Qiao B, Du E, Li L, et al. Prognostic significance of GPC5 expression in patients with prostate cancer. Tumour Biol. 2016;37:6413-8 pubmed publisher
    The objective of this study was to evaluate the protein level of glypican-5 (GPC5) and its relationship with clinicopathologic significance in prostate cancer...
  23. Shin J, Kim H, Park B, Bae J, Kim L, Cheong H, et al. Putative association of GPC5 polymorphism with the risk of inflammatory demyelinating diseases. J Neurol Sci. 2013;335:82-8 pubmed publisher
    ..b>Glypican 5 (GPC5) is known to be one of the susceptible genes for the risk of IDD, especially MS, based on genome-wide ..
  24. Witt R, Hecht M, Pazyra Murphy M, Cohen S, Noti C, van Kuppevelt T, et al. Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation. J Biol Chem. 2013;288:26275-88 pubmed publisher
    ..Here, we identify HSPGs containing a glypican 5 core protein and 2-O-sulfo-iduronic acid residues at the nonreducing ends of the glycans as co-receptors for Shh...
  25. Bassuk A, Muthuswamy L, Boland R, Smith T, Hulstrand A, Northrup H, et al. Copy number variation analysis implicates the cell polarity gene glypican 5 as a human spina bifida candidate gene. Hum Mol Genet. 2013;22:1097-111 pubmed publisher
    ..A third heterozygous deletion removed GPC5 and part of GPC6, genes encoding glypicans...
  26. Cavanillas M, Fernandez O, Comabella M, Alcina A, Fedetz M, Izquierdo G, et al. Replication of top markers of a genome-wide association study in multiple sclerosis in Spain. Genes Immun. 2011;12:110-5 pubmed publisher
    ..rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5)...
  27. Yuan S, Yu Z, Liu Q, Zhang M, Xiang Y, Wu N, et al. GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma. Oncogene. 2016;35:6120-6131 pubmed publisher
    Glypican-5 (GPC5) is a member of the heparin sulfate proteoglycans. Previous studies of GPC5 in lung tumorigenesis showed conflicting results...
  28. Sun Y, Zhao J, Yin X, Yuan X, Guo J, Bi J. miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma. Cell Prolif. 2016;49:636-43 pubmed publisher
    ..In addition, we identified Glypican-5 (GPC5) as a direct target gene of miR-297 in lung adenocarcinoma cells...
  29. Wang S, Qiu M, Xia W, Xu Y, Mao Q, Wang J, et al. Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a. Oncotarget. 2016;7:79736-79746 pubmed publisher
    We previously demonstrated that Glypican-5 (GPC5), one of the members of heparan sulfate proteoglycan, was a novel tumor metastasis suppressor in lung adenocarcinoma (LAC)...
  30. Zhao Z, Han C, Liu J, Wang C, Wang Y, Cheng L. GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma. Mol Med Rep. 2014;9:2540-6 pubmed publisher
    In the current study, a proportion of lung adenocarcinoma was shown to reduce GPC5 expression in the absence of transcriptional silencing of the tumor suppressor gene, GPC5, by aberrant methylation of CpG islands...
  31. Watanabe K, Yamada H, Yamaguchi Y. K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995;130:1207-18 pubmed
    ..These results indicate that K-glypican is a novel GPI-anchored HSPG involved in embryonic development. ..
  32. Li F, Shi W, Capurro M, Filmus J. Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J Cell Biol. 2011;192:691-704 pubmed publisher
    Glypican-5 (GPC5) is one of the six members of the glypican family. It has been previously reported that GPC5 stimulates the proliferation of rhabdomyosarcoma cells...
  33. Gieger C, Geistlinger L, Altmaier E, Hrabe de Angelis M, Kronenberg F, Meitinger T, et al. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 2008;4:e1000282 pubmed publisher
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge. ..
  34. Cénit M, Blanco Kelly F, De Las Heras V, Bartolome M, de la Concha E, Urcelay E, et al. Glypican 5 is an interferon-beta response gene: a replication study. Mult Scler. 2009;15:913-7 pubmed publisher
    ..results obtained at the two loci most strongly implicated in the response to interferon-beta treatment, HAPLN1 and GPC5. We performed a case-control study, analyzing 199 patients with MS treated with interferon-beta for at least 2 ..
  35. Rampersaud E, Damcott C, Fu M, Shen H, McArdle P, Shi X, et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes. 2007;56:3053-62 pubmed
    ..Our GWAS of type 2 diabetes identified several gene variants associated with type 2 diabetes, some of which are worthy of further study. ..
  36. Pelak K, Goldstein D, Walley N, Fellay J, Ge D, Shianna K, et al. Host determinants of HIV-1 control in African Americans. J Infect Dis. 2010;201:1141-9 pubmed publisher
  37. Yu W, Inoue J, Imoto I, Matsuo Y, Karpas A, Inazawa J. GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J Hum Genet. 2003;48:331-5 pubmed
    ..Although the commonly amplified region we defined was relatively large (approximately 4 Mb), only one true gene, GPC5, was found there...
  38. Veugelers M, De Cat B, Delande N, Esselens C, Bonk I, Vermeesch J, et al. A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32. Matrix Biol. 2001;20:375-85 pubmed
    ..We report the construction of a high-resolution 4 Mb sequence-ready BAC/PAC contig of the GPC5/GPC6 gene cluster on chromosome region 13q32...
  39. Zhang S, Thakur A, Liang Y, Wang T, Gao L, Yang T, et al. Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population. Dis Markers. 2015;2015:824304 pubmed publisher
    ..Gender-specific analysis in each model showed that genotypes "T/T" and "C/C" in rs2352028 of the Glypican 5 (GPC5) were associated with increased LC risk in males...
  40. De Cat B, David G. Developmental roles of the glypicans. Semin Cell Dev Biol. 2001;12:117-25 pubmed
    ..Their mechanism of action is not yet clear. Most likely, glypicans activate or determine the activity ranges of morphogens and growth factors such as FGFs, BMPs, Wnts, Hhs and IGFs. ..
  41. Cordell H, Töpf A, Mamasoula C, Postma A, Bentham J, Zelenika D, et al. Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013;22:1473-81 pubmed publisher
    ..27 in replication cohort, P = 7.7 × 10(-11) in combined populations]. Single nucleotide polymorphisms in the glypican 5 gene on chromosome 13q32 were also associated (P = 1.7 × 10(-7)) and replicated convincingly (P = 1...
  42. Yang X, Zhang Z, Qiu M, Hu J, Fan X, Wang J, et al. Glypican-5 is a novel metastasis suppressor gene in non-small cell lung cancer. Cancer Lett. 2013;341:265-73 pubmed publisher
    Glypican-5 (GPC5) may be a potential tumor suppressor gene in non-small cell lung cancer (NSCLC). The present study aimed to clarify the GPC5 expression pattern and to explore its potential functions in NSCLC...
  43. Mowry E, Carey R, Blasco M, Pelletier J, Duquette P, Villoslada P, et al. Multiple sclerosis susceptibility genes: associations with relapse severity and recovery. PLoS ONE. 2013;8:e75416 pubmed publisher
    ..The IL7R, TNFRSF1A, and GPC5 polymorphisms tended to be associated with having a second event within a year...
  44. Liu T, Zhang X, Sha K, Liu X, Zhang L, Wang B. miR-709 up-regulated in hepatocellular carcinoma, promotes proliferation and invasion by targeting GPC5. Cell Prolif. 2015;48:330-7 pubmed publisher
    ..Subsequent investigation revealed that glypican-5 (GPC5) was a direct and functional target of miR-709 in HCC cells where overexpression of miR-709 impaired GPC5-induced ..
  45. Lorentzen A, Melum E, Ellinghaus E, Smestad C, Mero I, Aarseth J, et al. Association to the Glypican-5 gene in multiple sclerosis. J Neuroimmunol. 2010;226:194-7 pubmed publisher
    ..006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene. ..
  46. Zheng Y, Kan M, Yu L, Niu X, Zhou D, He L, et al. GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese. Cancer Invest. 2012;30:13-9 pubmed publisher
    rs2352028 in GPC5 has been reported to be associated with the risk of lung cancer in never-smokers. We performed a replication study in 1,045 lung cancer patients and 1,094 controls of Han Chinese origin...
  47. Liu L, Zhong R, Zou L, Fu J, Zhu B, Chen W, et al. Variants in the 5'-upstream region of GPC5 confer risk of lung cancer in never smokers. Cancer Epidemiol. 2014;38:66-72 pubmed publisher
    A recent genome-wide study (GWAS) has identified GPC5 as a promising susceptibility gene for Lung cancer in never smokers (LCINS)...
  48. Byun E, Caillier S, Montalban X, Villoslada P, Fernandez O, Brassat D, et al. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol. 2008;65:337-44 pubmed publisher
    ..and nonresponders had significantly different genotype frequencies for SNPs located in many genes, including glypican 5, collagen type XXV alpha1, hyaluronan proteoglycan link protein, calpastatin, and neuronal PAS domain protein 3...