GP6

Summary

Gene Symbol: GP6
Description: glycoprotein VI platelet
Alias: BDPLT11, GPIV, GPVI, platelet glycoprotein VI, glycoprotein 6, platelet collagen receptor
Species: human
Products:     GP6

Top Publications

  1. Watson S, Auger J, McCarty O, Pearce A. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost. 2005;3:1752-62 pubmed
    ..of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alphaIIb beta3 (also known as GPIIbIIIa)...
  2. Asselin J, Gibbins J, Achison M, Lee Y, Morton L, Farndale R, et al. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1. Blood. 1997;89:1235-42 pubmed
    ..The results show an alpha2beta1-independent pathway of platelet activation by CRP that involves phosphorylation of syk and PLC gamma2. This pathway appears to contribute to platelet activation by collagen. ..
  3. Arthur J, Qiao J, Shen Y, Davis A, Dunne E, Berndt M, et al. ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways. J Thromb Haemost. 2012;10:1133-41 pubmed publisher
    Ligation of the platelet-specific collagen receptor, GPVI/FcR?, causes rapid, transient disulfide-dependent homodimerization, and the production of intracellular reactive oxygen species (ROS) generated by the NADPH oxidase, linked to GPVI ..
  4. Quinton T, Ozdener F, Dangelmaier C, Daniel J, Kunapuli S. Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. Blood. 2002;99:3228-34 pubmed
    Collagen activates platelets by transducing signals through glycoprotein VI (GPVI). It is not clear whether collagen can directly activate fibrinogen receptors on the adherent platelets without a role for positive feedback agonists...
  5. Joutsi Korhonen L, Smethurst P, Rankin A, Gray E, Ijsseldijk M, Onley C, et al. The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood. 2003;101:4372-9 pubmed
    ..GPIbIXV) over von Willebrand factor, adhesion by direct interaction with the integrin GPIaIIa, and signaling via GPVI. GPVI can be specifically agonized by cross-linked collagen-related peptide (CRP-XL), which results in a signaling ..
  6. Al Tamimi M, Mu F, Arthur J, Shen Y, Moroi M, Berndt M, et al. Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding. Platelets. 2009;20:75-82 pubmed publisher
    ..The platelet collagen receptor, glycoprotein (GP) VI, is critical for thrombus formation at arterial shear rates and is a potential ..
  7. Moroi M, Jung S, Okuma M, Shinmyozu K. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest. 1989;84:1440-5 pubmed
    ..decreased incorporations of both radioactivities into a 61-kD membrane glycoprotein (GP), which was identified as GPVI from its mobility on unreduced-reduced, two-dimensional SDS-PAGE. Sugiyama et al. (1987. Blood...
  8. Smethurst P, Onley D, Jarvis G, O Connor M, Knight C, Herr A, et al. Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets. J Biol Chem. 2007;282:1296-304 pubmed
    Collagen-related peptide is a selective agonist for the platelet collagen receptor Glycoprotein VI...
  9. Trifiro E, Williams S, Cheli Y, Furihata K, Pulcinelli F, Nugent D, et al. The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding. Blood. 2009;114:1893-9 pubmed publisher
    The 2 most common haplotypes of human GP6, GP6a and GP6b, generate the allelic isoforms glycoprotein VI (GPVI)a and GPVIb that differ by 5 amino acids: S219P, K237E, and T249A in the ectodomains, and Q317L and H322N in the cytoplasmic ..

More Information

Publications87

  1. Arthur J, Shen Y, Gardiner E, Coleman L, Murphy D, Kenny D, et al. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011;9:163-72 pubmed publisher
    ..species generation is one consequence of ligand engagement of platelet glycoprotein (GP) receptors GPIb-IX-V and GPVI, which bind VWF/collagen and initiate thrombosis at arterial shear; however, the precise molecular mechanism ..
  2. O Connor M, Smethurst P, Davies L, Joutsi Korhonen L, Onley D, Herr A, et al. Selective blockade of glycoprotein VI clustering on collagen helices. J Biol Chem. 2006;281:33505-10 pubmed
    Platelet activation by collagen relies on the interaction of the receptor glycoprotein VI (GPVI) with collagen helices. We have previously generated two recombinant single chain human antibodies (scFvs) to human GPVI...
  3. Siljander P, Munnix I, Smethurst P, Deckmyn H, Lindhout T, Ouwehand W, et al. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood. 2004;103:1333-41 pubmed
    The platelet glycoproteins (GPs) Ib, integrin alpha(2)beta(1), and GPVI are considered central to thrombus formation. Recently, their relative importance has been re-evaluated based on data from murine knockout models...
  4. Miura Y, Takahashi T, Jung S, Moroi M. Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. J Biol Chem. 2002;277:46197-204 pubmed
    Glycoprotein VI (GPVI) is a platelet-specific glycoprotein that has been indicated to react with collagen and activate platelets. Its structure was recently identified by cDNA cloning (Clemetson, J. M., Polgar, J., Magnenat, E., Wells, T...
  5. Jones C, Garner S, Moraes L, Kaiser W, Rankin A, Ouwehand W, et al. PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Lett. 2009;583:3618-24 pubmed publisher
    ..This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation. ..
  6. Clemetson J, Polgar J, Magnenat E, Wells T, Clemetson K. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem. 1999;274:29019-24 pubmed
    We have cloned the platelet collagen receptor glycoprotein (GP) VI from a human bone marrow cDNA library using rapid amplification of cDNA ends with platelet mRNA to complete the 5' end sequence...
  7. Motovska Z, Kvasnicka J, Widimsky P, Petr R, Hajkova J, Bobcikova P, et al. Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction. Thromb Res. 2010;125:e61-4 pubmed publisher
    ..676; 95% C.I. 1.159 to 11.628; p=0.027). The frequencies of GP VI and GP Ia gene polymorphisms were independent of one another (p=0.836). The presence of the GP VI 13254C allele is an independent predictor of premature MI. ..
  8. O Connor M, Smethurst P, Farndale R, Ouwehand W. Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen. J Thromb Haemost. 2006;4:869-73 pubmed
    ..mutagenesis of recombinant receptor fragments, we have previously identified residue lysine59 of the platelet collagen receptor glycoprotein VI (GPVI) as being critical for its interaction with the synthetic ligand collagen-related ..
  9. Jones C, Garner S, Angenent W, Bernard A, Berzuini C, Burns P, et al. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost. 2007;5:1756-65 pubmed
    ..868, 0.766 and 0.549); all subjects retaining their phenotype at recall. The effect of sequence variation at the GP6 locus accounted for approximately 35% of the variation in the CRP-XL response...
  10. Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, Ajzenberg N, et al. Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity. Arterioscler Thromb Vasc Biol. 2012;32:778-85 pubmed publisher
    The immune receptor homologue glycoprotein VI (GPVI)/FcR receptor ? chain complex is primarily responsible for platelet activation by collagen...
  11. Arthur J, Gardiner E, Matzaris M, Taylor S, Wijeyewickrema L, Ozaki Y, et al. Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thromb Haemost. 2005;93:716-23 pubmed
    The platelet collagen receptor, glycoprotein (GP)VI, initiates platelet aggregation at low shear stress while GPIb-IX-V, which binds von Willebrand factor, elicits platelet aggregation under high shear conditions...
  12. Lee F, van Lier M, Relou I, Foley L, Akkerman J, Heijnen H, et al. Lipid rafts facilitate the interaction of PECAM-1 with the glycoprotein VI-FcR gamma-chain complex in human platelets. J Biol Chem. 2006;281:39330-8 pubmed
    ..Here we show, by immunoprecipitation, that the GPVI-FcR gamma-chain complex associates with the immunoreceptor tyrosine-based inhibitory motif-containing receptor, ..
  13. Smethurst P, Joutsi Korhonen L, O Connor M, Wilson E, Jennings N, Garner S, et al. Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood. 2004;103:903-11 pubmed
    ..GP) VI is the major receptor responsible for platelet activation by collagen, but the collagen-binding surface of GPVI is unknown...
  14. Nieswandt B, Watson S. Platelet-collagen interaction: is GPVI the central receptor?. Blood. 2003;102:449-61 pubmed
    ..have been identified on platelets, most notably alpha2beta1 integrin and the immunoglobulin (Ig) superfamily member GPVI. Within the last few years, major advances have been made in understanding platelet-collagen interactions including ..
  15. Snoep J, Gaussem P, Eikenboom J, Emmerich J, Zwaginga J, Holmes C, et al. The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project. J Thromb Haemost. 2010;8:2377-84 pubmed publisher
    ..results have been published on the effects of T13254C (rs1613662), which distinguishes the two major isoforms of GP6, the gene encoding the platelet receptor glycoprotein VI, on platelet function and the risk of cardiovascular ..
  16. Pugh N, Simpson A, Smethurst P, de Groot P, Raynal N, Farndale R. Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. Blood. 2010;115:5069-79 pubmed publisher
  17. Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner J, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem. 2000;275:23998-4002 pubmed
    ..Human GPVI belongs to the immunoglobulin superfamily and is noncovalently associated with the FcRgamma chain that is involved ..
  18. Jandrot Perrus M, Busfield S, Lagrue A, Xiong X, Debili N, Chickering T, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000;96:1798-807 pubmed
    ..b>Platelet glycoprotein VI (GPVI) plays a crucial role in collagen-induced activation and aggregation of platelets, and people who ..
  19. Lecut C, Arocas V, Ulrichts H, Elbaz A, Villeval J, Lacapere J, et al. Identification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites. J Biol Chem. 2004;279:52293-9 pubmed
    Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is known about its interaction with its ligands...
  20. Horii K, Kahn M, Herr A. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006;108:936-42 pubmed
    ..In humans and mice, collagen activation of platelets is mediated by glycoprotein VI (GPVI), a receptor that is homologous to immune receptors but bears little sequence similarity to known matrix protein ..
  21. Hughan S, Hughes C, McCarty O, Schweighoffer E, Soultanova I, Ware J, et al. GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb Vasc Biol. 2007;27:422-9 pubmed
    ..Potentiation in the presence of PP2 was lost in the absence of FcRgamma-chain or GPVI confirming that it was mediated through the immunoglobulin receptor...
  22. Suzuki Inoue K, Tulasne D, Shen Y, Bori Sanz T, Inoue O, Jung S, et al. Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem. 2002;277:21561-6 pubmed
    The glycoprotein VI (GPVI)-Fc receptor (FcR) gamma-chain complex, a key activatory receptor for collagen on platelet surface membranes, is constitutively associated with the Src family kinases Fyn and Lyn...
  23. Moroi A, Watson S. Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β. J Thromb Haemost. 2015;13:1139-50 pubmed publisher
    ..activation of Akt and mitogen-activated protein kinases (MAPKs) has been shown to enhance platelet activation by GPVI, but their role in CLEC-2 signaling is not known...
  24. Lopes Pires M, Clarke S, Marcondes S, Gibbins J. Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling. PLoS ONE. 2017;12:e0186981 pubmed publisher
    ..We report that LPS increased the aggregation of washed platelets stimulated by thromboxane (U46619) or GPVI collagen receptor agonists, effects that were prevented by a TLR4 antagonist...
  25. Baker J, Griggs R, Falati S, Poole A. GPIb potentiates GPVI-induced responses in human platelets. Platelets. 2004;15:207-14 pubmed
    ..therefore in vivo platelets are likely to encounter both of these agonists simultaneously, through glycoprotein VI (GPVI) and alpha2beta1 receptors for collagen and GPIb-V-IX and alphaIIbbeta3 receptors for vWF...
  26. Li P, Qiao J, Xu K. [Advances of Studies on Platelet GPVI as Antithrombotic Target -Review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:264-269 pubmed publisher
    ..The current clinical antithrombotic therapy showed a high efficiency, but at risk of bleeding. Platelet glycoprotein VI (GPVI) is a platelet-specific receptor and its binding with collagen is critical for platelet activation...
  27. Rayes J, Lax S, Wichaiyo S, Watson S, Di Y, Lombard S, et al. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. Nat Commun. 2017;8:2239 pubmed publisher
    ..through the podoplanin and collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI), respectively. Both receptors regulate endothelial permeability and prevent peri-vascular bleeding in inflammation...
  28. Qiao J, Arthur J, Gardiner E, Andrews R, Zeng L, Xu K. Regulation of platelet activation and thrombus formation by reactive oxygen species. Redox Biol. 2018;14:126-130 pubmed publisher
    ..b>GPVI forms a functional complex with the Fc receptor ?-chain (FcR?) that, following receptor dimerization, signals via ..
  29. Protty M, Watkins N, Colombo D, Thomas S, Heath V, Herbert J, et al. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem J. 2009;417:391-400 pubmed publisher
    ..Finally, Tspan9 was shown to be a component of tetraspanin microdomains that included the collagen receptor GPVI (glycoprotein VI) and integrin alpha6beta1, but not the von Willebrand receptor GPIbalpha or the integrins ..
  30. Nofer J, Herminghaus G, Brodde M, Morgenstern E, Rust S, Engel T, et al. Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). J Biol Chem. 2004;279:34032-7 pubmed
    ..The expression of platelet membrane receptors such as GPVI, alpha2beta1 integrin, and GPIIb/IIIa, the collagen-induced changes in phosphatidylserine and cholesterol ..
  31. Kubisz P, Ivanková J, Skerenová M, Stasko J, Holly P. The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. Hematology. 2012;17:355-62 pubmed publisher
    The aim of the study was to evaluate the genetic variability of the GP6 gene in patients with sticky platelet syndrome (SPS), a disorder characterized by platelet hyperaggregability, and thus to identify the genetic changes of the ..
  32. Johnson A, Yanek L, Chen M, Faraday N, Larson M, Tofler G, et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010;42:608-13 pubmed publisher
    ..We identified associations of seven loci with platelet aggregation near or within GP6 (P=4.6x10(-13)), PEAR1 (P=3.4x10(-12)), ADRA2A (P=3.3x10(-11)), PIK3CG (P=3.1x10(-9)), JMJD1C (P=1...
  33. Stevenson W, Rabbolini D, Beutler L, Chen Q, Gabrielli S, Mackay J, et al. Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1. Blood. 2015;126:2027-30 pubmed publisher
    ..This mutation caused a transcription defect at the promoter of known FLI1 target genes GP6, GP9, and ITGA2B, as measured by luciferase assay in HEK293 cells, and decreased the expression of these target ..
  34. Alshehri O, Hughes C, Montague S, Watson S, Frampton J, Bender M, et al. Fibrin activates GPVI in human and mouse platelets. Blood. 2015;126:1601-8 pubmed publisher
    The glycoprotein VI (GPVI)-Fc receptor γ (FcRγ) chain is the major platelet signaling receptor for collagen...
  35. Thomas D, Getz T, Newman T, Dangelmaier C, Carpino N, Kunapuli S, et al. A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood. 2010;116:2570-8 pubmed publisher
    ..In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling...
  36. Mangin P, Tang C, Bourdon C, Loyau S, Freund M, Hechler B, et al. A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents. J Pharmacol Exp Ther. 2012;341:156-63 pubmed publisher
    Glycoprotein VI (GPVI) has been proposed as a promising antiplatelet target, because its blockade prevents experimental thrombosis without impairing hemostasis...
  37. Planamente S, Salih O, Manoli E, Albesa Jové D, Freemont P, Filloux A. TssA forms a gp6-like ring attached to the type VI secretion sheath. EMBO J. 2016;35:1613-27 pubmed publisher
    ..and impacts its behaviour in vivo In the phage, the first disc of the gp18 sheath sits on a baseplate wherein gp6 is a dodecameric ring...
  38. Rigg R, Aslan J, Healy L, Wallisch M, Thierheimer M, Loren C, et al. Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function. Am J Physiol Cell Physiol. 2016;310:C373-80 pubmed publisher
    ..via activation of the effector protein phospholipase Cγ2 downstream of the platelet membrane glycoprotein VI (GPVI)...
  39. Kraft P, Schuhmann M, Fluri F, Lorenz K, Zernecke A, Stoll G, et al. Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke. Stroke. 2015;46:3502-6 pubmed publisher
    ..Animals were pretreated with anti-GPVI antibodies or treated 1 hour after stroke induction with anti-GPIb or anti-GPIIb/IIIa antigen-binding fragments, ..
  40. Xiao Y, Liu X, Meng D, Tao J, Gu Y, Yin H, et al. The role of soil bacterial community during winter fallow period in the incidence of tobacco bacterial wilt disease. Appl Microbiol Biotechnol. 2018;102:2399-2412 pubmed publisher
    ..These genera, such as Arthrobacter, Pseudomonas, Acidobacteria GP6, and Pasteuria, may be potential biological control agents for bacterial wilt...
  41. Bori Sanz T, Inoue K, Berndt M, Watson S, Tulasne D. Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain. J Biol Chem. 2003;278:35914-22 pubmed
    The glycoprotein VI (GPVI).Fc receptor gamma-chain (FcRgamma-chain) complex is the major activation receptor for collagen on platelets...
  42. Takano K, Asazuma N, Satoh K, Yatomi Y, Ozaki Y. Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Platelets. 2004;15:223-9 pubmed
    ..Convulxin, a GPVI-selective agonist, also induced PMP formation at the magnitude which far exceeds those of other agonists, such as ..
  43. Gardiner E, Arthur J, Kahn M, Berndt M, Andrews R. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood. 2004;104:3611-7 pubmed
    ..we observed that incubation of platelets with convulxin, collagen, or collagen-related peptide (CRP) resulted in GPVI signaling-dependent loss of surface GPVI and the appearance of an approximately 55-kDa soluble fragment of GPVI as ..
  44. Peters J, Furlong M, Asai D, Harrison M, Geahlen R. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem. 1996;271:4755-62 pubmed
    ..Thus, once activated, Syk releases from the aggregated antigen receptor complex and is free to associate with and phosphorylate soluble proteins including alpha-tubulin. ..
  45. Bigalke B, Krämer B, Seizer P, Fateh Moghadam S, Gawaz M, Lindemann S. Diagnostic and therapeutic potentials of platelet glycoprotein VI. Semin Thromb Hemost. 2010;36:203-11 pubmed publisher
    ..Collagen binding to platelet glycoprotein VI (GPVI) mediates the initial adhesion of the rolling platelet to the vascular wound...
  46. Yoshida H, Murono S, Ueno T, Nakanishi Y, Tsuji A, Hatano M, et al. Usefulness of human papillomavirus detection in oral rinse as a biomarker of oropharyngeal cancer. Acta Otolaryngol. 2017;137:773-777 pubmed publisher
    The detection of human papillomavirus (HPV)-DNA in oral rinse with auto-nested GP5+/GP6 + PCR is useful as a biomarker of oropharyngeal cancer...
  47. Matthews A, Noy P, Reyat J, Tomlinson M. Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids. Platelets. 2017;28:333-341 pubmed publisher
    ..On these cells, ADAM10 is the principal sheddase for the platelet collagen receptor GPVI, and the regulatory TspanC8s are Tspan14, 15, and 33, as determined from proteomic data...
  48. Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger L, et al. RhoG protein regulates glycoprotein VI-Fc receptor ?-chain complex-mediated platelet activation and thrombus formation. J Biol Chem. 2013;288:34230-8 pubmed publisher
    ..integrin ?IIb?3 activation, and ?-granule and dense granule secretion in response to the glycoprotein VI (GPVI) agonists collagen-related peptide (CRP) and convulxin were significantly inhibited in RhoG-deficient platelets...
  49. Gardiner E, Arthur J, Shen Y, Karunakaran D, Moore L, Am Esch J, et al. GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events. Platelets. 2010;21:244-52 pubmed publisher
    Platelet glycoprotein (GP)Ib-IX-V, which binds von Willebrand factor (VWF), and GPVI, which binds collagen, form an adhesion-signaling complex on platelets and mediate platelet adhesion in flowing blood...
  50. Sun B, Tao L, Lin S, Calingasan N, Li J, Tandon N, et al. Expression of glycoprotein VI in vascular endothelial cells. Platelets. 2003;14:225-32 pubmed
    ..To date, GPVI expression has been found only in platelets and megakaryocytes...
  51. Nissinen L, Koivunen J, Kapyla J, Salmela M, Nieminen J, Jokinen J, et al. Novel ?2?1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012;287:44694-702 pubmed publisher
  52. Shaffer J, Kammerer C, Dorn J, Ferrell R, Iacoviello L, Trevisan M, et al. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. Nutr Metab Cardiovasc Dis. 2011;21:546-52 pubmed publisher
    b>Glycoprotein 6 (GP6) is a platelet-specific collagen receptor implicated in the thrombotic pathway to acute myocardial infarction (AMI), but a possible genetic relationship between GP6 and AMI is poorly understood...
  53. Bray P, Howard T, Vittinghoff E, Sane D, Herrington D. Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Blood. 2007;109:1862-9 pubmed
    ..We genotyped 2090 women in Heart and Estrogen/progestin Replacement Study for functional polymorphisms in GP1BA and GP6 and assessed the coronary heart disease (CHD) event rate over 5.8 years of follow-up...
  54. Carrim N, Walsh T, Consonni A, Torti M, Berndt M, Metharom P. Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. PLoS ONE. 2014;9:e113679 pubmed publisher
    We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation...
  55. Sokol J, Skerenová M, Biringer K, Lasabova Z, Stasko J, Kubisz P. Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. Expert Rev Hematol. 2015;8:863-8 pubmed publisher
    ..The aim of this study is to evaluate the variability of GP6 regulatory regions in a group of patients with platelet hyperaggregability manifested as miscarriage compared with ..
  56. Cabeza N, Li Z, Schulz C, Kremmer E, Massberg S, Bültmann A, et al. Surface expression of collagen receptor Fc receptor-gamma/glycoprotein VI is enhanced on platelets in type 2 diabetes and mediates release of CD40 ligand and activation of endothelial cells. Diabetes. 2004;53:2117-21 pubmed
    ..In this study, the platelet collagen receptor glycoprotein VI (GPVI) was studied in 385 patients with type 2 diabetes...
  57. Pears C, Thornber K, Auger J, Hughes C, Grygielska B, Protty M, et al. Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. PLoS ONE. 2008;3:e3793 pubmed publisher
    ..platelets and undergoes transient tyrosine phosphorylation upon stimulation by thrombin or the collagen receptor, GPVI, which becomes sustained in the presence of the pan-PKC inhibitor, Ro 31-8220...
  58. Stack J, Madigan A, Helbert L, Dunne E, Gardiner E, Andrews R, et al. Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis. PLoS ONE. 2017;12:e0188027 pubmed publisher
    ..via engagement of Fc?RIIa results in proteolytic cleavage and shedding of platelet specific glycoprotein VI (GPVI) which can be detected in the plasma as soluble GPVI (sGPVI)...
  59. Degen H, Borst O, Ziegler M, Mojica Munoz A, Jamasbi J, Walker B, et al. ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions. J Am Heart Assoc. 2017;6: pubmed publisher
    GPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI-Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies...
  60. Yu Z, Dong N, Gao W, Bai X, Ruan C. [Study on T13254C polymorphism of the platelet membrane glycoprotein VI in Chinese Han population]. Zhonghua Xue Ye Xue Za Zhi. 2005;26:140-3 pubmed
    To investigate the T13254C polymorphism frequency in GPVI gene among Chinese Han population and its relevance to the arterial thrombotic diseases...
  61. Kawaguchi T, Hashimoto R, Yokota H. The human megakaryocytic cell line UT-7/TPO expresses functional platelet agonist signals mediated through GPVI and thromboxane receptor. Cell Biol Int. 2010;34:943-9 pubmed publisher
    ..Unlike other megakaryocytic cell lines, UT-7/TPO was found to express GPVI and its associate signal molecule of FcRgamma (Fc receptor gamma chain)...
  62. Quinter P, Dangelmaier C, Quinton T, Kunapuli S, Daniel J. Glycoprotein VI agonists have distinct dependences on the lipid raft environment. J Thromb Haemost. 2007;5:362-8 pubmed
    It has been reported that the association of glycoprotein VI (GPVI) with lipid rafts regulates GPVI signaling in platelets...
  63. Lecut C, Feijge M, Cosemans J, Jandrot Perrus M, Heemskerk J. Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin. Thromb Haemost. 2005;94:107-14 pubmed
    ..With all preparations, blocking of glycoprotein VI (GPVI) with 9O12 antibody abrogated the collagen-enhanced thrombin generation, regardless of the alpha2beta 1 activation ..
  64. Evans D, Zhu G, Duffy D, Montgomery G, Frazer I, Martin N. Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q. Eur J Hum Genet. 2004;12:835-42 pubmed
  65. Furihata K, Kunicki T. Characterization of human glycoprotein VI gene 5' regulatory and promoter regions. Arterioscler Thromb Vasc Biol. 2002;22:1733-9 pubmed
    b>Platelet glycoprotein VI is a collagen receptor belonging to the immunoglobulin-like protein family that is essential for platelet interactions with collagen and is exclusively expressed in the megakaryocytic lineage...
  66. Poulter N, Pollitt A, Owen D, Gardiner E, Andrews R, Shimizu H, et al. Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets. J Thromb Haemost. 2017;15:549-564 pubmed publisher
    Essentials Dimeric high-affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. Spatio-temporal organization of platelet GPVI-dimers was evaluated using advanced microscopy...
  67. Aslan J, Itakura A, Haley K, Tormoen G, Loren C, Baker S, et al. p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arterioscler Thromb Vasc Biol. 2013;33:1544-51 pubmed publisher
    ..These results suggest that PAK serves as an orchestrator of platelet functional responses after activation downstream of the platelet collagen receptor, glycoprotein receptor VI.
  68. Pignatelli P, Pastori D, Bartimoccia S, Menichelli D, Vicario T, Nocella C, et al. Anti Xa oral anticoagulants inhibit in vivo platelet activation by modulating glycoprotein VI shedding. Pharmacol Res. 2016;113:484-489 pubmed publisher
    ..rivaroxaban, to warfarin, and to investigate the potential underlying mechanism by evaluating soluble glycoprotein GPVI (sGPVI), a protein involved in platelet activation...
  69. Bigalke B, Stellos K, Weig H, Geisler T, Seizer P, Kremmer E, et al. Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS). Basic Res Cardiol. 2009;104:352-7 pubmed publisher
    The platelet collagen receptor glycoprotein VI (GPVI) mediates platelet adhesion to subendothelial matrix and thrombus formation in acute coronary syndrome (ACS)...
  70. Dumont B, Minullina I, Loyau S, Monteiro R, Lacapere J, Arocas V, et al. Chimeric Fc receptors identify ligand binding regions in human glycoprotein VI. J Mol Biol. 2006;361:877-87 pubmed
    ..Our aim was to identify the structures determining GPVI specificity...
  71. Wright B, Stanley R, Kaiser W, Mills D, Gibbins J. Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes. Proteomics. 2011;11:4588-92 pubmed publisher
    ..The majority of proteins identified by tandem mass spectrometry are involved in signalling. The effect of GPVI stimulation on levels of specific proteins in subcellular compartments was compared and analysed using in silico ..
  72. Kunicki T, Williams S, Nugent D, Harrison P, Segal H, Syed A, et al. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. Thromb Haemost. 2009;101:123-33 pubmed
    ..integrins alpha2beta1and alphaIIbbeta3 (ITGA2, ITGA2B, and ITGB3), platelet glycoproteins Ibalpha and VI (GPIBA and GP6), the purinergic receptor P2Y1 (P2RY1), and prostaglandin H synthase 1 (PTGS1 = COX1)...
  73. Chang C, Chung C, Tu Y, Tsai C, Hsu C, Peng H, et al. Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet. Arterioscler Thromb Vasc Biol. 2017;37:1307-1314 pubmed publisher
    ..On the contrary, bleeding defects associated with glycoprotein VI (GPVI) expression deficiency are usually slightly prolonged bleeding times...
  74. Sigalov A. More on: glycoprotein VI oligomerization: a novel concept of platelet inhibition. J Thromb Haemost. 2007;5:2310-2 pubmed
  75. Wijeyewickrema L, Gardiner E, Moroi M, Berndt M, Andrews R. Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI. Thromb Haemost. 2007;98:1285-90 pubmed
    ..study, we show that two snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of GPVI by a mechanism that involves activation of endogenous platelet metalloproteinases...
  76. Al Tamimi M, Grigoriadis G, Tran H, Paul E, Servadei P, Berndt M, et al. Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa. Blood. 2011;117:3912-20 pubmed publisher
    This study evaluated shedding of the platelet collagen receptor, glycoprotein VI (GPVI) in human plasma...
  77. Bigalke B, Elvers M, Schonberger T, Gawaz M. Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy. Curr Drug Targets. 2011;12:1821-30 pubmed
    One of the key receptors involved in the prothrombotic stage of an acute coronary syndrome (ACS) is platelet glycoprotein VI (GPVI)...