Gene Symbol: GP1BA
Description: glycoprotein Ib platelet subunit alpha
Alias: BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, VWDP, platelet glycoprotein Ib alpha chain, GP-Ib alpha, antigen CD42b-alpha, glycoprotein Ib (platelet), alpha polypeptide, glycoprotein Ib platelet alpha subunit, mutant platelet membrane glycoprotein Ib-alpha, platelet membrane glycoprotein 1b-alpha subunit, platelet membrane glycoprotein Ib-alpha
Species: human
Products:     GP1BA

Top Publications

  1. Lopez J, Ludwig E, McCarthy B. Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications. J Biol Chem. 1992;267:10055-61 pubmed
    ..Such a change may alter the susceptibility of platelets to shear-induced activation, a process that requires an interaction between glycoprotein Ib and von Willebrand factor. ..
  2. Sabo T, Maurer M. Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II. Biochemistry. 2009;48:7110-22 pubmed publisher
    ..On the surface of platelets resides the GpIbalpha/beta-GpIX-GpV membrane-bound receptor complex...
  3. Iniesta J, Corral J, Gonzalez Conejero R, Piqueras C, Vicente V. Polymorphisms of platelet adhesive receptors: do they play a role in primary intracerebral hemorrhage?. Cerebrovasc Dis. 2003;15:51-5 pubmed
    ..The frequency of genotypes and alleles were similar between patients and controls. Our results suggest that these polymorphisms play a minor role in PIH. ..
  4. Huizinga E, Tsuji S, Romijn R, Schiphorst M, de Groot P, Sixma J, et al. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002;297:1176-9 pubmed
    Transient interactions of platelet-receptor glycoprotein Ibalpha (GpIbalpha) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis...
  5. Dumas J, Kumar R, McDonagh T, Sullivan F, Stahl M, Somers W, et al. Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations. J Biol Chem. 2004;279:23327-34 pubmed
    ..high shear conditions is mediated by a direct interaction between the platelet receptor glycoprotein Ibalpha (GpIbalpha) and the A1 domain of the von Willebrand factor (VWF). Here we report the 2...
  6. Nishio K, Anderson P, Zheng X, Sadler J. Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13. Proc Natl Acad Sci U S A. 2004;101:10578-83 pubmed
    ..Domains A1 and A3 bind to platelet glycoprotein Ibalpha (GPIbalpha) and collagen, respectively...
  7. Du X. Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Curr Opin Hematol. 2007;14:262-9 pubmed
    ..Characterization of intracellular molecules and pathways in glycoprotein Ib-IX-V signaling has implications in the development of new agents and for the use of existing drugs that affect glycoprotein Ib-IX-V signaling. ..
  8. Li C, Vindigni A, Sadler J, Wardell M. Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. J Biol Chem. 2001;276:6161-8 pubmed
  9. Yago T, Lou J, Wu T, Yang J, Miner J, Coburn L, et al. Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest. 2008;118:3195-207 pubmed publisher
    Arterial blood flow enhances glycoprotein Ibalpha (GPIbalpha) binding to vWF, which initiates platelet adhesion to injured vessels...

More Information


  1. Lopez J, Chung D, Fujikawa K, Hagen F, Papayannopoulou T, Roth G. Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein. Proc Natl Acad Sci U S A. 1987;84:5615-9 pubmed
    ..The extracytoplasmic domain is followed by a potential transmembrane segment of approximately 29 amino acids and a potential intracellular domain of approximately 100 amino acids located at the carboxyl end of the molecule. ..
  2. Ju L, Dong J, Cruz M, Zhu C. The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ib?. J Biol Chem. 2013;288:32289-301 pubmed publisher
    ..These data reveal the structural determinants of VWF activation by hemodynamic force of the circulation. ..
  3. Abboud N, Amin H, Ghazouani L, Ben Haj Khalifa S, Ben Khalafallah A, Aded F, et al. Polymorphisms of human platelet alloantigens HPA-1 and HPA-2 associated with severe coronary artery disease. Cardiovasc Pathol. 2010;19:302-7 pubmed publisher
    ..92; 95% CI=1.43-5.94) haplotypes with CAD, after adjustment for a number of covariates. Our results suggest that HPA-1/HPA-2 haplotypes may be considered to be a major risk factor for CAD in middle-aged Tunisians. ..
  4. Williamson D, Pikovski I, Cranmer S, Mangin P, Mistry N, Domagala T, et al. Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem. 2002;277:2151-9 pubmed
    ..with the membrane skeleton of platelets is dependent on a specific interaction between the cytoplasmic tail of GPIbalpha and filamin-1...
  5. Kim J, Zhang C, Zhang X, Springer T. A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature. 2010;466:992-5 pubmed publisher
    ..Binding of the A1 domain in VWF to the glycoprotein Ib alpha subunit (GPIbalpha) on the surface of platelets mediates crosslinking of platelets to one another and the formation of a platelet ..
  6. Celikel R, McClintock R, Roberts J, Mendolicchio G, Ware J, Varughese K, et al. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003;301:218-21 pubmed
    ..We have determined the structure of platelet glycoprotein Ibalpha (GpIbalpha) bound to thrombin at 2...
  7. Uff S, Clemetson J, Harrison T, Clemetson K, Emsley J. Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation. J Biol Chem. 2002;277:35657-63 pubmed
    ..Using molecular docking of the GPIb and vWF-A1 crystal structures, we were also able to model the GPIb.vWF-A1 complex. ..
  8. Feng S, Reséndiz J, Lu X, Kroll M. Filamin A binding to the cytoplasmic tail of glycoprotein Ibalpha regulates von Willebrand factor-induced platelet activation. Blood. 2003;102:2122-9 pubmed
    We examined the hypothesis that filamin A binding to the cytoplasmic tail of platelet glycoprotein Ibalpha (GpIbalpha) is regulated by pathologic shear stress and modulates von Willebrand factor (VWF)-induced platelet activation...
  9. Peck G, Smeeth L, Whittaker J, Casas J, Hingorani A, Sharma P. The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults. PLoS ONE. 2008;3:e3691 pubmed publisher
    ..Importantly, for several alleles previously found to be associated with protection from ischaemic stroke, there was a trend towards an increased risk of haemorrhagic stroke. ..
  10. de Haas C, Weeterings C, Vughs M, de Groot P, van Strijp J, Lisman T. Staphylococcal superantigen-like 5 activates platelets and supports platelet adhesion under flow conditions, which involves glycoprotein Ibalpha and alpha IIb beta 3. J Thromb Haemost. 2009;7:1867-74 pubmed publisher
    ..SSL5 activates and aggregates platelets in a GPIb alpha-dependent manner, which could be important in colonization of the vascular bed and evasion of the immune system by S. aureus. ..
  11. Nowak A, Canis K, Riddell A, Laffan M, McKinnon T. O-linked glycosylation of von Willebrand factor modulates the interaction with platelet receptor glycoprotein Ib under static and shear stress conditions. Blood. 2012;120:214-22 pubmed publisher
    ..These data demonstrate an important functional role of VWF OLGs under shear stress conditions. ..
  12. Kroll M, Harris T, Moake J, Handin R, Schafer A. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. J Clin Invest. 1991;88:1568-73 pubmed
    ..This signal then causes PKC activation and increases of [Ca2+]i, which promote platelet secretion and potentiate aggregation. ..
  13. Harmon J, Jamieson G. The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets. J Biol Chem. 1986;261:13224-9 pubmed
    ..These results demonstrate that both high and moderate affinity binding of thrombin to platelets is completely expressed in the glycocalicin portion of GPIb. ..
  14. Nakayama T, Matsushita T, Dong Z, Sadler J, Jorieux S, Mazurier C, et al. Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond. J Biol Chem. 2002;277:22063-72 pubmed
    ..The crystallographic structure of the A1 domain suggests that GPIb binding is influenced by the molecular interface between the two regions and that the antibody binding to the interface inhibits binding. ..
  15. Romo G, Dong J, Schade A, Gardiner E, Kansas G, Li C, et al. The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med. 1999;190:803-14 pubmed
    ..Thus, the GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium. ..
  16. Marchese P, Murata M, Mazzucato M, Pradella P, De Marco L, Ware J, et al. Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. J Biol Chem. 1995;270:9571-8 pubmed
    ..There are two distinct but partially overlapping regions of GP Ib alpha thought to be involved in interacting with vWF (residues 251-279) and alpha-thrombin (residues 271-284); they ..
  17. Wu Y, Asazuma N, Satoh K, Yatomi Y, Takafuta T, Berndt M, et al. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood. 2003;101:3469-76 pubmed
    ..These findings taken together suggest that the p85 subunit of PI 3-kinase mediates GPIb-related activation signals and activates Src independently of the enzymatic activity of PI 3- kinase. ..
  18. Hess D, Schaller J, Rickli E, Clemetson K. Identification of the disulphide bonds in human platelet glycocalicin. Eur J Biochem. 1991;199:389-93 pubmed
    ..The position and linkage of these two disulphide bonds are now determined to be 209-248 and 211-264 and the relevance of this double-loop structure for glycoprotein Ib/IX function is discussed. ..
  19. Andrews R, Gorman J, Booth W, Corino G, Castaldi P, Berndt M. Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the alpha-chain of membrane glycoprotein Ib on intact platelets with bis(sulfosuccinimidyl) suberate. Biochemistry. 1989;28:8326-36 pubmed
  20. Dayananda K, Singh I, Mondal N, Neelamegham S. von Willebrand factor self-association on platelet GpIbalpha under hydrodynamic shear: effect on shear-induced platelet activation. Blood. 2010;116:3990-8 pubmed publisher
    ..This can trigger mechanotransduction and cell activation by enhancing the drag force applied on the cell-surface receptor. ..
  21. Li S, Wang Z, Liao Y, Zhang W, Shi Q, Yan R, et al. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. J Thromb Haemost. 2010;8:341-50 pubmed publisher those occurring during apoptosis, however, it is still unclear whether platelet apoptosis is induced by the GPIbalpha-VWF interaction...
  22. Dumas J, Kumar R, Seehra J, Somers W, Mosyak L. Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science. 2003;301:222-6 pubmed
    Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury...
  23. Li Y, Lu J, Prochownik E. Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha. J Biol Chem. 2009;284:1410-8 pubmed publisher
    Glycoprotein Ib alpha (GpIbalpha), a trans-membrane glycoprotein, is expressed on the surface of megakaryocytes and platelets, where, in association with glycoprotein Ib beta, glycoprotein V, and glycoprotein IX, it normally forms the ..
  24. Kenny D, Jonsson O, Morateck P, Montgomery R. Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein. Blood. 1998;92:175-83 pubmed
    ..The complex is composed of four membrane-spanning glycoproteins (GP): GPIbalpha, GPIbbeta, GPIX, and GPV...
  25. Arthur J, Gardiner E, Matzaris M, Taylor S, Wijeyewickrema L, Ozaki Y, et al. Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thromb Haemost. 2005;93:716-23 pubmed
    ..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation. ..
  26. Ulrichts H, Udvardy M, Lenting P, Pareyn I, Vandeputte N, Vanhoorelbeke K, et al. Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V. J Biol Chem. 2006;281:4699-707 pubmed
    ..The previously described anti-VWF monoclonal antibody 1C1E7 enhances VWF/GPIbalpha binding and recognizes an epitope in the amino acids 764-1035 region in the N-terminal D'D3 domains...
  27. Li Y, Lu J, Cohen D, Prochownik E. Transformation, genomic instability and senescence mediated by platelet/megakaryocyte glycoprotein Ibalpha. Oncogene. 2008;27:1599-609 pubmed
    b>GpIbalpha, a subunit of the von Willebrand factor receptor, functions during blood clotting to promote platelet adhesion and activation...
  28. Griffith G, Wirostko B, Lee H, Cornell L, McDaniel J, Zamora D, et al. Treatment of corneal chemical alkali burns with a crosslinked thiolated hyaluronic acid film. Burns. 2018;44:1179-1186 pubmed publisher
    ..Wounds were immediately rinsed with balanced salt solution (BSS). CMHA-S films were placed in the left inferior fornix of five injured and five uninjured animals...
  29. Arifin N, Abu Osman N, Ali S, Gholizadeh H, Wan Abas W. Evaluation of postural steadiness in below-knee amputees when wearing different prosthetic feet during various sensory conditions using the Biodex® Stability System. Proc Inst Mech Eng H. 2015;229:491-8 pubmed publisher
    ..The purpose of this study was to explore the ability of the Biodex(®) Stability System (BSS) to quantify postural steadiness in below-knee amputees...
  30. Nishiya T, Kainoh M, Murata M, Handa M, Ikeda Y. Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ib alpha under flow conditions: specific synergy of receptor-ligand interactions. Blood. 2002;100:136-42 pubmed
    ..This study thus has confirmed for the first time the proposed mechanisms of platelet adhesion to the collagen surface under flow conditions using the liposome system. ..
  31. Von Zup M, Lassaline M, Kass P, Miller P, Thomasy S. Effects of 0.2% brimonidine and 0.2% brimonidine-0.5% timolol on intraocular pressure and pupil size in normal equine eyes. Equine Vet J. 2017;49:810-814 pubmed publisher
    ..was treated with brimonidine or brimonidine-timolol and the opposite eye was treated with balanced salt solution (BSS)...
  32. Kliem S, Lohmann A, Mößle T, Brahler E. German Beck Scale for Suicide Ideation (BSS): psychometric properties from a representative population survey. BMC Psychiatry. 2017;17:389 pubmed publisher
    ..The aim of this study was to validate the German version of the Beck Scale for Suicide Ideation (BSS) in a sample representative for the Federal Republic of Germany...
  33. Li S, Yaseen Z, Kim H, Briggs J, Duffy M, Frechette Hagan A, et al. Entrapment as a mediator of suicide crises. BMC Psychiatry. 2018;18:4 pubmed publisher
    ..The Suicide Crisis Inventory (SCI) and Beck Scale for Suicidal Ideation (BSS) were administered to 200 high-risk adult psychiatric inpatients hospitalized following SI or suicide attempt, ..
  34. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, et al. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci U S A. 2016;113:3054-9 pubmed publisher
    ..CTCF-binding sites (CTCF-BSs) have been propagated throughout the genome by transposons in certain primate lineages, but CTCF binding has not ..
  35. Hecht J, Zsengellér Z, Spiel M, Karumanchi S, Rosen S. Revisiting decidual vasculopathy. Placenta. 2016;42:37-43 pubmed publisher
    ..We describe DV using stains for CD31, CD34, Cd42b, CD68, desmin, fibrin and Masson's trichrome in patients with preeclampsia and fetal growth restriction...
  36. Kunicki T, Williams S, Nugent D, Harrison P, Segal H, Syed A, et al. Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. Thromb Haemost. 2009;101:123-33 pubmed
    ..for integrins alpha2beta1and alphaIIbbeta3 (ITGA2, ITGA2B, and ITGB3), platelet glycoproteins Ibalpha and VI (GPIBA and GP6), the purinergic receptor P2Y1 (P2RY1), and prostaglandin H synthase 1 (PTGS1 = COX1)...
  37. Wilczek P, Major R, Lipinska L, Lackner J, Mzyk A. Thrombogenicity and biocompatibility studies of reduced graphene oxide modified acellular pulmonary valve tissue. Mater Sci Eng C Mater Biol Appl. 2015;53:310-21 pubmed publisher
    ..The following cellular receptors were then analysed: CD42a, CD42b, CD41a, CD40, CD65P and PAC-1...
  38. Tait A, Dong J, Lopez J, Dawes I, Chong B. Site-directed mutagenesis of platelet glycoprotein Ib alpha demonstrating residues involved in the sulfation of tyrosines 276, 278, and 279. Blood. 2002;99:4422-7 pubmed
    ..The second mutation involves changing the lysine residues at 253, 258, and 262 to alanine. This also led to distinct changes in VWF binding and abolition of sulfation. ..
  39. Vega Memije M, Boeta Ángeles L, Cuevas González J. Basal Cell Carcinoma in a Patient With Brooke-Spiegler Syndrome. Skinmed. 2015;13:325-8 pubmed
    A 46-year-old woman was diagnosed with Brooke-Spiegler syndrome (BSS) with lesions on her head, predominantly on the center of her face, auricles, and scalp...
  40. Schade A, Arya M, Gao S, Diz Kucukkaya R, Anvari B, McIntire L, et al. Cytoplasmic truncation of glycoprotein Ib alpha weakens its interaction with von Willebrand factor and impairs cell adhesion. Biochemistry. 2003;42:2245-51 pubmed
    ..Studies measuring the GP Ibalpha-VWF bond strength of three of the mutants using laser tweezers showed that progressive deletion of the cytoplasmic domain led to progressive weakening of the strength of individual GP Ibalpha-VWF bonds. ..
  41. Daga S, Shepherd J, Hung R, Callaghan J, Dawson D, Padfield G, et al. GPIb VNTR C/C genotype may predict embolic events in infective endocarditis. J Heart Valve Dis. 2013;22:133-41 pubmed
  42. Kang J, Park K, Han J, Yang H, Kang H, Koo B, et al. Usefulness of the Baseline Syntax Score to Predict 3-Year Outcome After Complete Revascularization by Percutaneous Coronary Intervention. Am J Cardiol. 2016;118:641-6 pubmed publisher
    ..In this study, we aimed to investigate whether the baseline SYNTAX score (bSS) can predict adverse clinical events in patients receiving CR...
  43. Ye B, Shen W, Wang D, Li P, Zhang Z, Shi M, et al. [ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners]. Mol Biol (Mosk). 2016;50:496-503 pubmed publisher
    ..By integrated analysis of public datasets, we provided evidence that a majority of ZNF143 binding sites (BSs) were involved in CTCF-mediated chromatin interaction networks (CTCF-CINs) by overlapping with cohesin-BSs and CTCF-..
  44. Remenova T, Morand O, Amato D, Chadha Boreham H, Tsurutani S, Marquardt T. A double-blind, randomized, placebo-controlled trial studying the effects of Saccharomyces boulardii on the gastrointestinal tolerability, safety, and pharmacokinetics of miglustat. Orphanet J Rare Dis. 2015;10:81 pubmed publisher
    ..was the total number of 'diarrhea days' (≥3 loose stools within a 24-h period meeting Bristol Stool Scores [BSS] 6-7) based on WHO criteria. Secondary endpoints comprised numerous other diarrhea and GI tolerability indices...
  45. Strohmeier A, Först G, Tauber P, Schubert R. Membrane/Water Partition Coefficients of Bile Salts Determined Using Laurdan as a Fluorescent Probe. Biophys J. 2016;111:1714-1723 pubmed publisher
    The interaction of liposomal membranes composed of soybean phosphatidylcholine with the bile salts (BSs) cholate (Ch), glycocholate (GC), chenodeoxycholate (CDC), and glycochenodeoxycholate (GCDC) was studied...
  46. Labounek R, Bridwell D, Marecek R, Lamos M, Mikl M, Slavíček T, et al. Stable Scalp EEG Spatiospectral Patterns Across Paradigms Estimated by Group ICA. Brain Topogr. 2018;31:76-89 pubmed publisher
    ..Various blind source separation (BSS) approaches have been developed and implemented in order to decompose these oscillations, and a subset of ..
  47. Cure K, Kocaturk E, Koku Aksu A, Yuksel T, Leblebici C, Ozekinci S, et al. Brooke-Spiegler syndrome: focus on reflectance confocal microscopy findings of trichoepithelioma and flat cylindroma. Clin Exp Dermatol. 2017;42:906-909 pubmed publisher
    Brooke-Spiegler syndrome (BSS) is a rare, autosomal dominant disorder characterized by multiple adnexal tumours, especially trichoepitheliomas, cylindromas and occasionally spiradenomas...
  48. Cretti F. Assessment of occupational radiation dose in interventional settings. Med Lav. 2018;109:57-67 pubmed publisher
    ..The eye lens dose limit of the new European Directive (BSS 2013) was exceeded in 2013 by three medical doctors, prompting prescription of protective glasses...
  49. Nosratabadi M, Halvaiepour Z. A Structural Equation Modeling of the Relationships between Depression, Drug Abuse and Social Support with Suicidal Ideation among Soldiers in Iran in 2015. J Res Health Sci. 2016;16:212-216 pubmed
    ..Social Support Questionnaire (SSQ), the Beck Depression Inventory-II (BDI-II), the Beck Scale for Suicide Ideation (BSS) and the Possibility of Drug Abuse Scale (LDAS)...
  50. Mehta A, Mohammed B, Martin E, Brophy D, Gailani D, Desai U. Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin. J Thromb Haemost. 2016;14:828-38 pubmed publisher
    ..Overall, this study highlights the promise of the allosteric inhibition approach, and presents SbO4L as a novel anticoagulant with potentially reduced bleeding side effects. ..
  51. Kokavec J, Min S, Tan M, Gilhotra J, Newland H, Durkin S, et al. Biochemical analysis of the living human vitreous. Clin Exp Ophthalmol. 2016;44:597-609 pubmed publisher
    ..Vitreous biochemistry was significantly different from the vitreous substitute BSS Plus (Alcon, USA)...
  52. Rasoolinajad M, Abedinia N, Noorbala A, Mohraz M, Badie B, Hamad A, et al. Relationship Among HIV-Related Stigma, Mental Health and Quality of life for HIV-Positive Patients in Tehran. AIDS Behav. 2018;22:3773-3782 pubmed publisher
    ..PLWHA completed Socio-Demographic Characteristics, Berger Scale Stigma (BSS), General Health Questionnaire (GHQ-28), WHO Quality of life-BREF (WHOQOL-BREF) and Philips Social Support ..
  53. Berny M, White T, Tucker E, Bush Pelc L, Di Cera E, Gruber A, et al. Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol. 2008;28:329-34 pubmed
    ..These observations demonstrate that the thrombin mutant WE, while not activating platelets, retains the ability to interact with platelets through GPIb, and inhibits GPIb-dependent binding to von Willebrand factor-collagen under shear. ..
  54. Li X, Zhang Z, Ye L, Meng J, Zhao Z, Liu Z, et al. Acute ocular hypertension disrupts barrier integrity and pump function in rat corneal endothelial cells. Sci Rep. 2017;7:6951 pubmed publisher
    ..The anterior chamber of the right eye of Sprague-Dawley rats was irrigated with Balanced Salt Solution (BSS) for two hours, and the left eye served as a control to determine the time-dependent effects of AOH on endothelial ..
  55. Pellitero S, Reverter J, Tassies D, Pizarro E, Monteagudo J, Salinas I, et al. Polymorphisms in platelet glycoproteins Ia and IIIa are associated with arterial thrombosis and carotid atherosclerosis in type 2 diabetes. Thromb Haemost. 2010;103:630-7 pubmed publisher
    ..42; p=0.04). In conclusion, the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination, may confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes. ..
  56. Jedlitschky G, Tirschmann K, Lubenow L, Nieuwenhuis H, Akkerman J, Greinacher A, et al. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood. 2004;104:3603-10 pubmed
    ..The results indicate a function of MRP4 in platelet mediator storage and inhibition of MRP4 may represent a novel mechanism for inhibition of platelet function by some anti-inflammatory drugs. ..
  57. Lisman T, de Groot P. The interaction of recombinant factor VIIa with platelet glycoprotein Ib. Thromb Res. 2010;125 Suppl 1:S13-5 pubmed publisher
    ..This interaction appears to slightly enhance tissue factor-independent thrombin generation. These findings add to our understanding of the mechanism of action of rFVIIa and may lead to improved therapeutic use of the drug. ..
  58. Mehrotra A, Jamdar J, Sharma P, Godbole C, Singh S, Das K, et al. Constipation in degenerative cervico-thoracic spine myelopathy: a simple co-existence or a complex inter-relationship?. Eur Spine J. 2017;26:2318-2323 pubmed publisher
    ..4:1 with mean age 46.16) underwent evaluation including Bristol stool scale (BSS), PFT and uroflowmetry. All cases were evaluated by gastroenterologist to rule out any intrinsic bowel disease...
  59. Welsby I, Podgoreanu M, Phillips Bute B, Mathew J, Smith P, Newman M, et al. Genetic factors contribute to bleeding after cardiac surgery. J Thromb Haemost. 2005;3:1206-12 pubmed
    ..Accounting for genotype may be necessary when stratifying risk of bleeding after cardiac surgery. ..
  60. Xue M, Chen K, Yin H. Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. Chin J Integr Med. 2008;14:267-73 pubmed publisher
    ..The mean fluorescence intensity (MFI) of GP I b, GP II b- III a, and GMP-140 (CD42b, CD61, CD62p) in patients and healthy persons was measured with flow cytometry, the polymorphism of HPA-3 gene was ..
  61. Suzuki K, Hayashi T, Akiba J, Yahagi A, Tajima K, Satoh S, et al. StyI polymorphism at nucleotide 1610 in the human platelet glycoprotein Ib alpha gene. Jpn J Hum Genet. 1996;41:419-21 pubmed
  62. Candore G, Piazza G, Crivello A, Grimaldi M, Orlando V, Caruso M, et al. Association between platelet glycoprotein Ib-alpha and myocardial infarction: results of a pilot study performed in male and female patients from Sicily. Ann N Y Acad Sci. 2006;1089:502-8 pubmed
    ..Thus, our results indicate that the HPA-2 polymorphisms are not associated with an increased risk for AMI at early onset (< 46 years) both in men and in women. ..
  63. Yun T, Baglia F, Myles T, Navaneetham D, Lopez J, Walsh P, et al. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem. 2003;278:48112-9 pubmed
    ..GPIb alpha plays a critical role in the co-localization of thrombin and FXI and the resultant efficient activation of FXI. ..
  64. Schwarz V, Düsing P, Liman T, Werner C, Herm J, Bachelier K, et al. Marathon running increases circulating endothelial- and thrombocyte-derived microparticles. Eur J Prev Cardiol. 2017;:2047487317744364 pubmed publisher
    ..microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14...
  65. Cheng H, Yan R, Li S, Yuan Y, Liu J, Ruan C, et al. Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibalpha shedding. Am J Physiol Heart Circ Physiol. 2009;297:H2128-35 pubmed publisher
    ..Here we show that shear-induced interaction of platelets with immobilized VWF results in GPIbalpha ectodomain shedding...
  66. Hillmann A, Shields D, Fitzgerald D, Kenny D. Polymorphisms in glycoprotein (GP) lb alpha are not associated with adverse outcomes in primigravidae. J Obstet Gynaecol. 2000;20:250-5 pubmed
    ..90, CI=0.4-1.9). Genetic variants of GPlbalpha are unlikely to contribute to adverse events associated with thrombosis in a primigravidae population. ..
  67. Andrews R, Berndt M. Bernard-Soulier syndrome: an update. Semin Thromb Hemost. 2013;39:656-62 pubmed publisher
    Bernard-Soulier syndrome (BSS) is a rare inherited platelet bleeding disorder characterized by low platelet count and abnormally large platelets (macrothrombocytopenia)...
  68. Chen J, Ling M, Fu X, Lopez J, Chung D. Simultaneous exposure of sites in von Willebrand factor for glycoprotein Ib binding and ADAMTS13 cleavage: studies with ristocetin. Arterioscler Thromb Vasc Biol. 2012;32:2625-30 pubmed publisher
  69. Wenger R, Wicki A, Kieffer N, Adolph S, Hameister H, Clemetson K. The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha. Gene. 1989;85:517-24 pubmed
    ..The gpIb alpha gene was found to be located on chromosome 17 in region 17p12-ter, by in situ hybridization. ..
  70. Dubois C, Steiner B, Meyer Reigner S. Contribution of PAR-1, PAR-4 and GPIbalpha in intracellular signaling leading to the cleavage of the beta3 cytoplasmic domain during thrombin-induced platelet aggregation. Thromb Haemost. 2004;91:733-42 pubmed
    ..Interestingly, in the absence of GPIbalpha or following inhibition of thrombin binding to GPIbalpha, there is a reduction in the thrombin-induced calcium ..
  71. Koike S, Kawamura K, Kimura Y, Shibuya N, Kimura H, Ogasawara Y. Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Free Radic Biol Med. 2017;113:355-362 pubmed publisher
    Previous studies indicated that bound sulfur species (BSS), including hydrogen polysulfide (H2Sn), have various physiological functions in mammalian cells...
  72. Shields D, Fitzgerald A, O Neill P, Muckian C, Kenny D, Moran B, et al. The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists. Pharmacogenomics J. 2002;2:182-90 pubmed
    ..These were the platelet glycoprotein (GP) receptors GPIIIa, GPIa, GPIbalpha; platelet ligands beta-fibrinogen and von Willebrand Factor (vWF); interleukins (IL) IL-1RN, and IL-6; adhesion ..
  73. Hou J, Morgan K, Tucker D, Konyn A, Poulsen C, Tanaka Y, et al. An improved artifacts removal method for high dimensional EEG. J Neurosci Methods. 2016;268:31-42 pubmed publisher
    Multiple noncephalic electrical sources superpose with brain signals in the recorded EEG. Blind source separation (BSS) methods such as independent component analysis (ICA) have been shown to separate noncephalic artifacts as unique ..
  74. Mangin P, David T, Lavaud V, Cranmer S, Pikovski I, Jackson S, et al. Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood. 2004;104:420-7 pubmed
    ..Interaction of the 14-3-3zeta adaptor protein with the C-terminal 606-610 phosphoserine motif of the GPIbalpha subunit has been implicated in the control of alpha(IIb)beta(3) activation and cell spreading...
  75. Mangin P, Receveur N, Wurtz V, David T, Gachet C, Lanza F. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. J Thromb Haemost. 2009;7:1550-5 pubmed publisher
    ..In addition, their interaction was found to critically require the same GPIbalpha domains (580-590 and 605-610) already identified as essential for 14-3-3zeta binding, in agreement with the ..
  76. Faraday N, Martinez E, Scharpf R, Kasch Semenza L, Dorman T, Pronovost P, et al. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology. 2004;101:1291-7 pubmed
    ..Polymorphisms in platelet glycoprotein (GP) IIIa and GPIbalpha are associated with myocardial ischemic risk in nonsurgical settings, but their relation to perioperative ..
  77. Yin H, Liu J, Li Z, Berndt M, Lowell C, Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood. 2008;112:1139-46 pubmed publisher
  78. Bray P, Howard T, Vittinghoff E, Sane D, Herrington D. Effect of genetic variations in platelet glycoproteins Ibalpha and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Blood. 2007;109:1862-9 pubmed
    ..We genotyped 2090 women in Heart and Estrogen/progestin Replacement Study for functional polymorphisms in GP1BA and GP6 and assessed the coronary heart disease (CHD) event rate over 5.8 years of follow-up...