gp130

Summary

Gene Symbol: gp130
Description: interleukin 6 signal transducer (gp130, oncostatin M receptor)
Alias: CD130, CDW130, GP130, IL-6RB, CD130 antigen, IL-6 receptor subunit beta, IL-6R subunit beta, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, interleukin receptor beta chain, interleukin-6 receptor subunit beta, membrane glycoprotein 130, membrane glycoprotein gp130, oncostatin-M receptor subunit alpha
Species: human

Top Publications

  1. ncbi The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice
    E Gyotoku
    Department of Dermatology, Hiroshima University, Faculty of Medicine, Japan
    Arch Dermatol Res 293:508-14. 2001
  2. ncbi gp130 receptor ligands as potential therapeutic targets for obesity
    Mark A Febbraio
    Cellular and Molecular Metabolism Laboratory, Division of Diabetes and Metabolism, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Clin Invest 117:841-9. 2007
  3. ncbi Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130
    Yuichi Hashimoto
    Department of Pharmacology and Neuroscience, Tokyo Medical University, Shinjuku ku, Tokyo 160 8402, Japan
    Mol Biol Cell 20:2864-73. 2009
  4. ncbi Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
  5. ncbi Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    M Narazaki
    Division of Immunology, Osaka University, Japan
    Blood 82:1120-6. 1993
  6. ncbi Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance
    Oliver Zolk
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Circulation 106:1442-6. 2002
  7. ncbi A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome
    Lucia Gottardo
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:205-10. 2008
  8. ncbi Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
    Simone Radtke
    Institut fur Biochemie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    J Biol Chem 277:11297-305. 2002
  9. ncbi WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    Stefan Pflanz
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 172:2225-31. 2004
  10. ncbi Dissection of the signalling requirements of interleukin-6-stimulated myeloma cell growth
    J D French
    Department of Immunology, Mayo Graduate and Medical School, Mayo Clinic, Rochester, Minnesota, USA
    Acta Oncol 39:777-81. 2000

Research Grants

  1. IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSION
    CHARLES O BRIEN; Fiscal Year: 2002
  2. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
  3. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2005
  4. Molecular & Genetic Determinants of Outcome in Breast Cancer
    Angela DeMichele; Fiscal Year: 2007
  5. Studies of HHV-8 vIL-6 Function
    John Nicholas; Fiscal Year: 2007
  6. MOLECULAR BIOLOGY & FUNCTION OF PLATELET MEMBRANE GP130
    Peter Newman; Fiscal Year: 1990
  7. INHIBITION OF IL-6 AND STAT3 IN RHEUMATOID ARTHRITIS
    Lionel Ivashkiv; Fiscal Year: 2004
  8. REGULATION OF IL-6 EXPRESSION IN ASTROCYTES
    ETTY BENVENISTE; Fiscal Year: 2004
  9. Transplantation: Graft Cell Promotion of Rejection
    David Perkins; Fiscal Year: 2004
  10. Inflammatory factors, genes and stress induced pressure natriuresis in youth
    Haidong Zhu; Fiscal Year: 2007

Detail Information

Publications177 found, 100 shown here

  1. ncbi The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice
    E Gyotoku
    Department of Dermatology, Hiroshima University, Faculty of Medicine, Japan
    Arch Dermatol Res 293:508-14. 2001
    ..Among the proinflammatory mediators, leukemia inhibitory factor (LIF), which shares a receptor component (gp130 subunit) with interleukin-6 (IL-6), has been identified as a mast cell growth-enhancing factor produced by cells ..
  2. ncbi gp130 receptor ligands as potential therapeutic targets for obesity
    Mark A Febbraio
    Cellular and Molecular Metabolism Laboratory, Division of Diabetes and Metabolism, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Clin Invest 117:841-9. 2007
    ..Recent research has focused on the role that gp130 receptor ligands may play as potential therapeutic targets in obesity...
  3. ncbi Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130
    Yuichi Hashimoto
    Department of Pharmacology and Neuroscience, Tokyo Medical University, Shinjuku ku, Tokyo 160 8402, Japan
    Mol Biol Cell 20:2864-73. 2009
    ..In this study, a series of loss-of-function tests indicated that gp130, the common subunit of receptors belonging to the IL-6 receptor family, was essential for HN-induced ..
  4. ncbi Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..5, 95% CI, 1.1-6.0). Additional SNPs in genes encoding IGF-1, IGF binding protein-2, IRS2, and gp130 also showed suggestive associations with multiple myeloma risk...
  5. ncbi Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    M Narazaki
    Division of Immunology, Osaka University, Japan
    Blood 82:1120-6. 1993
    The interleukin-6 (IL-6) signal is transduced through membrane-anchored gp130, which is associated with IL-6 receptor (IL-6R) in the presence of IL-6...
  6. ncbi Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance
    Oliver Zolk
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Circulation 106:1442-6. 2002
    ..Although cardiac CT-1 gene expression is known to be upregulated in some animal models of congestive heart failure, the activation state of the CT-1 system in patients with congestive heart failure is unknown...
  7. ncbi A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome
    Lucia Gottardo
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:205-10. 2008
    The interleukin 6 signal transducer (IL6ST, also known as gp130) is a ubiquitously expressed intermediate of the interleukin-6 signaling pathway...
  8. ncbi Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
    Simone Radtke
    Institut fur Biochemie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    J Biol Chem 277:11297-305. 2002
    ..Finally we demonstrate that in Jak1-deficient cells, the endogenous OSMR is significantly down-regulated, an effect that can be reversed by transient expression of Jak1 in these cells...
  9. ncbi WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    Stefan Pflanz
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 172:2225-31. 2004
    ..In this study, we describe that WSX-1 together with gp130 constitutes a functional signal-transducing receptor for IL-27...
  10. ncbi Dissection of the signalling requirements of interleukin-6-stimulated myeloma cell growth
    J D French
    Department of Immunology, Mayo Graduate and Medical School, Mayo Clinic, Rochester, Minnesota, USA
    Acta Oncol 39:777-81. 2000
    ..Second. we are using a chimeric receptor approach to identify the regions of gp130, the signal transducing component of the IL-6 receptor, that are essential for myeloma cell proliferation...
  11. ncbi Effects of Viscum album extract therapy in patients with cancer: relation with interleukin-6, soluble interleukin-6 receptor, and soluble gp130
    Eva Kovacs
    Society of Cancer Research, Arlesheim, Switzerland
    J Altern Complement Med 10:241-6. 2004
    ..VA) extract therapy on interleukin (IL)-12, IL-16, IL-6, soluble interleukin-6 receptor (sIL-6R), and soluble gp130 (sgp130) in patients with cancer...
  12. ncbi How does interleukin-6 affect the membrane expressions of interleukin-6 receptor and gp130 and the proliferation of the human myeloma cell line OPM-2?
    Eva Kovacs
    Society of Cancer Research, Kirschweg 9, 4144 Arlesheim, Switzerland
    Biomed Pharmacother 57:489-94. 2003
    ..on the following parameters in the human myeloma cell line OPM-2: membrane expression of IL-6 receptor (IL-6R) and gp130, proliferation of the tumour cells and the amount of the soluble IL-6 receptor (sIL-6R) in the supernatant...
  13. ncbi The pro- and anti-inflammatory properties of the cytokine interleukin-6
    Jürgen Scheller
    Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    Biochim Biophys Acta 1813:878-88. 2011
    ..a membrane bound interleukin-6 receptor, which upon ligand binding associates with the signaling receptor protein gp130. Gp130 dimerizes, leading to the activation of Janus kinases and subsequent phosphorylation of tyrosine residues ..
  14. ncbi The interleukin-6/interleukin-6-receptor system is activated in donor hearts
    Gabriele Plenz
    Department of Cardiothoracic Surgery, Muenster University, Muenster, Germany
    J Am Coll Cardiol 39:1508-12. 2002
    ..To assess the potential of the donor heart to respond to interleukin-6 (IL6), the present study investigated the expression of IL6 receptor components in the myocardium of donor hearts before transplantation...
  15. ncbi Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation
    D R Rosell
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Neuroscience 122:329-48. 2003
    Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner...
  16. ncbi Evidence for altered activity of the IL-6 pathway in chronic rhinosinusitis with nasal polyps
    Anju T Peters
    Division of Allergy Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Allergy Clin Immunol 125:397-403.e10. 2010
    ..The IL-6 receptor and the membrane protein, glycoprotein 130 (gp130), form an active signaling complex that signals through signal transducer and activator of transcription 3 (STAT3) ..
  17. ncbi Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling
    H Li
    The Molecular Virology Laboratories, Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Virol 75:3325-34. 2001
    ..Like these proteins, vIL-6 mediates its effects through the gp130 signal transducer, but signaling is not dependent on the structurally related IL-6 receptor (IL-6R; gp80) subunit ..
  18. ncbi Measurements of IL-6, soluble IL-6 receptor and soluble gp130 in sera of B-cell lymphoma patients. Does viscum album treatment affect these parameters?
    E Kovacs
    Society of Cancer Research, Kirschweg, Arlesheim, Switzerland
    Biomed Pharmacother 56:152-8. 2002
    ..This cytokine binds to soluble IL-6 receptor (sIL-6R) circulating in blood, leading to signal transduction via gp130. Soluble IL-6R shows agonistic activity for IL-6, and the soluble form of gp130 (sgp130) an antagonistic effect ..
  19. ncbi Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease
    K Ikeda
    Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    Brain Res 726:91-7. 1996
    ..These molecules share the signal transducing receptor component, gp130. IL-6 triggers homodimerization of gp130, whereas CNTF and LIF induce heterodimerization of gp130 and LIF receptor...
  20. ncbi Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    T G Boulton
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    J Biol Chem 269:11648-55. 1994
    ..signaling by inducing either homodimerization of the "beta" signal transducing receptor component gp130 (in the case of IL6) or heterodimerization between gp130 and the gp130-related LIFR beta (in the case of CNTF, LIF,..
  21. ncbi Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
    Torsten Wuestefeld
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 278:11281-8. 2003
    ..and its family members for liver regeneration after PH, we used conditional knockout mice for glycoprotein 130 (gp130), the common signal transducer of all IL6 family members...
  22. ncbi A 130-kDa plasma membrane glycoprotein involved in Dictyostelium phagocytosis
    C P Chia
    School of Biological Sciences, University of Nebraska Lincoln 68588 0118, USA
    Exp Cell Res 227:182-9. 1996
    ..A 130-kDa glycoprotein (gp130) was associated with cytoskeletons of bacterially but not axenically grown cells, suggesting a cytoskeletal ..
  23. ncbi Glycopeptidome of a heavily N-glycosylated cell surface glycoprotein of Dictyostelium implicated in cell adhesion
    Christa L Feasley
    Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Proteome Res 9:3495-510. 2010
    Genetic analysis has implicated the cell surface glycoprotein gp130 in cell interactions of the social amoeba Dictyostelium, and information about the utilization of the 18 N-glycosylation sequons present in gp130 is needed to identify ..
  24. ncbi Interleukin-6 and other gp130-dependent cytokines selectively inhibit proliferation of macrophage-lineage hemopoietic progenitor cells
    R Clutterbuck
    Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Exp Hematol 28:1120-8. 2000
    ..We have investigated the roles of interleukin-6 and other gp130-dependent ligands on the proliferation of macrophage-lineage hemopoietic progenitor cells.
  25. ncbi C/EBP-delta induction by gp130 signaling. Role in transition to myelin gene expressing phenotype in a melanoma cell line model
    Anil K Kamaraju
    Department of Molecular Genetics, Weizmann Institute of Science, Rehov Herzl, Rehovot 76100, Israel
    J Biol Chem 279:3852-61. 2004
    ..We previously observed that triggering of the gp130 receptor system by the IL6RIL6 ligand, comprising interleukin-6 (IL-6) fused to the soluble IL-6 receptor, induces ..
  26. ncbi Inhibition of interleukin-6-transsignaling via gp130-Fc in hemorrhagic shock and sepsis
    Soeren Torge Mees
    Department of General Surgery, University of Muenster, Muenster, Germany
    J Surg Res 157:235-42. 2009
    ..b>Gp130-Fc is able to bind the IL-6/sIL-6R complex, and beneficial effects of IL-6 blockade in chronic inflammatory ..
  27. ncbi Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure
    Bryan G Helwig
    Department of Anatomy and Physiology, Coles Hall 228, Kansas State University, 1600 Denison Ave, Manhattan, KS 66506, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1165-73. 2007
    ..IL-6, via binding to the IL-6 receptor (IL-6R)/glycoprotein 130 (gp130) complex influences cellular and physiological responses...
  28. ncbi gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells
    X Sui
    Department of Clinical Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 92:2859-63. 1995
    b>gp130, a signal-transducing receptor component of interleukin 6 (IL-6), associates with an IL-6 and IL-6 receptor (IL-6) complex and transduces signals...
  29. ncbi Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
    Shin ichiro Sawa
    Laboratory of Developmental Immunology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Exp Med 203:1459-70. 2006
    Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated ..
  30. ncbi A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease
    K Mitsuyama
    Second Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Clin Exp Immunol 143:125-31. 2006
    The presence and the role of soluble gp130, the soluble form of a component of the interleukin (IL)-6 receptor complex, were investigated in inflammatory bowel disease...
  31. ncbi Investigation of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130) in sera of cancer patients
    E Kovacs
    Society for Cancer Research, Arlesheim, Switzerland
    Biomed Pharmacother 55:391-6. 2001
    ..Soluble IL-6 receptor as agonist enhances the biological effect of released IL-6. Soluble gp130 as antagonist inhibits the effect of the IL-6/sIL-6R complex...
  32. ncbi Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins
    Silke Metz
    Institut fur Biochemie, Pauwelsstrasse 30, Universitätsklinikum RWTH Aachen, Germany
    J Biol Chem 282:1238-48. 2007
    ..developed a fusion protein consisting of the ligand binding domains of the IL-6 receptor subunits IL-6Ralpha and gp130 that acts as a highly potent IL-6 inhibitor...
  33. ncbi Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130
    H Yawata
    Division of Immunology, Osaka University, Japan
    EMBO J 12:1705-12. 1993
    ..binding of IL-6, IL-6R becomes associated extracellularly with a non-IL-6-binding but signal transducing molecule, gp130, and the IL-6 signal is generated...
  34. ncbi TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex
    Johannes G Bode
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Medizinische Klinik der Heinrich Heine Universität, Dusseldorf, Germany
    J Immunol 171:257-66. 2003
    ..tyrosine phosphatase Src homology protein tyrosine phosphatase 2 (SHP2) to the signal-transducing receptor subunit gp130 attenuates IL-6-mediated STAT-activation, we were interested in whether TNF-alpha also induces the association of ..
  35. ncbi In vivo modulation of soluble "antagonistic" IL-6 receptor synthesis and release in ESRD
    Bruno Memoli
    Department of Nephrology, University Federico II of Naples, Via Tasso 91 B, Napoli 80127, Italy
    J Am Soc Nephrol 16:1099-107. 2005
    Soluble gp130 (sgp130) is a soluble circulating receptor of IL-6 with "antagonistic" biologic activity. It is generated independently by either shedding of the extracellular domain of membrane gp130 or alternative mRNA splicing...
  36. ncbi Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
    Marcin Majka
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 30:751-60. 2002
    ..IL-11, leukemia inhibitory factor (LIF), cilliary neurotropic factor (CNTF), and oncostatin (OSM), which bind to gp130 protein-coupled receptors...
  37. ncbi Cytostatic and cytocidal effects of mistletoe (Viscum album L.) quercus extract Iscador
    Eva Kovacs
    Verein für Krebsforschung, Institute Hiscia, Arlesheim, Switzerland
    Arzneimittelforschung 56:467-73. 2006
    ..All three multiple myeloma cell lines expressed surface IL-6R and gp130, the B cell lymphomas expressed only gp130...
  38. ncbi Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies
    G Muller-Newen
    Institut fur Biochemie, Rheinisch Westfälische Technische Hochschule Aachen, D 52074 Aachen, Germany
    J Biol Chem 275:4579-86. 2000
    The transmembrane glycoprotein gp130 belongs to the family of hematopoietic cytokine receptors. It represents the common signal transducing receptor component of the so called interleukin-6-type cytokines...
  39. ncbi Leukaemia inhibitory factor receptor and gp130 in the human Fallopian tube and endometrium before and after mifepristone treatment and in the human preimplantation embryo
    K Wånggren
    Department of Woman and Child Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Mol Hum Reprod 13:391-7. 2007
    ..tube, endometrium and preimplantation embryo and to study the effect of mifepristone on the expression of LIFR and gp130 in the Fallopian tube...
  40. ncbi Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
    Exp Hematol 30:1248-56. 2002
    Studies on mice lacking the common receptor subunit gp130 reveal that activation of gp130-dependent signaling pathways is essential for normal fetal and adult hematopoiesis...
  41. ncbi Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns
    T Bando
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 142:1263-71. 2006
    Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines...
  42. ncbi Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Victoria, Australia
    Blood 109:2380-8. 2007
    We have previously demonstrated that STAT3 hyperactivation via the interleukin 6 (IL-6) cytokine family receptor gp130 in gp130 (Y757F/Y757F) mice leads to numerous hematopoietic and lymphoid pathologies, including neutrophilia, ..
  43. ncbi Infarction-induced cytokines cause local depletion of tyrosine hydroxylase in cardiac sympathetic nerves
    Diana C Parrish
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Exp Physiol 95:304-14. 2010
    ..Inflammatory cytokines that act through gp130 are elevated in the heart after myocardial infarction...
  44. ncbi Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation
    Gustavo Salguero
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Hypertension 54:1035-42. 2009
    ..Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid artery ligation...
  45. ncbi Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1
    Kurt J Sales
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    Am J Pathol 176:435-45. 2010
    ..Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha...
  46. ncbi Cytokine-dependent gp130 receptor subunit regulates rat modified axial-pattern epigastric flap
    Sadanori Akita
    Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine, Nagasaki, Japan
    J Invest Surg 15:137-51. 2002
    We investigated axial-pattern flap survival by modulating the cytokine receptor component, gp130, to elucidate the mechanism of the cytokine receptor modulation subsequently leading to the initiation of local angiogenesis and blood-flow ..
  47. ncbi Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice
    Daniela C Kroy
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Hepatology 51:463-73. 2010
    ..IL-6)-type cytokines in hepatocytes we investigated the role of IL-6 and its shared receptor, glycoprotein 130 (gp130), in a mouse model of steatohepatitis...
  48. ncbi Mimicry of erythropoietin and interleukin-6 signalling by an antibody/cytokine receptor chimera in murine myeloid 32D cells
    Masahiro Kawahara
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Tokyo, Japan
    J Biochem 141:563-71. 2007
    ..and the phosphorylation status of intracellular signal transducers between the erythropoietin receptor (EpoR)- or gp130-based chimeric receptors and wild-type EpoR or EpoR-gp130 chimera, respectively...
  49. ncbi An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT
    Y Fujitani
    Department of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    Oncogene 14:751-61. 1997
    ..In signaling from gp130, a common signal transducer for the IL-6 family cytokines, STAT3, a transcription factor that contains an SH2 ..
  50. ncbi Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex
    Patrick J Lupardus
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Structure 19:45-55. 2011
    The shared cytokine receptor gp130 signals as a homodimer or heterodimer through activation of Janus kinases (Jaks) associated with the receptor intracellular domains...
  51. ncbi Structural biology of shared cytokine receptors
    Xinquan Wang
    Howard Hughes Medical Institute, Stanford University School of Medicine, Departments of Molecular and Cellular Physiology, and Structural Biology, Stanford, California 94305, USA
    Annu Rev Immunol 27:29-60. 2009
    ..topology and ligand recognition mechanisms used by our three principal shared cytokine signaling receptors-gp130, gamma(c), and beta(c)...
  52. ncbi Characterization of the signaling capacities of the novel gp130-like cytokine receptor
    Alexandra Dreuw
    Institut fur Biochemie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Biol Chem 279:36112-20. 2004
    The gp130-like receptor (GPL) is a recently cloned member of the family of type I cytokine receptors. The name reflects its close relationship to gp130, the common receptor subunit of the interleukin (IL)-6-type cytokines...
  53. ncbi Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6
    Daming Chen
    Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans St, Rm 309, Baltimore, MD 21287, USA
    J Virol 83:6874-82. 2009
    ..cellular IL-6 proteins in that it does not require the nonsignaling alpha-receptor subunit for the formation of gp130-based signal transducing complexes and also is largely retained intracellularly rather than being secreted...
  54. ncbi Downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes
    Ruijin Shao
    Dept of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Univ of Gothenburg, Medicinareg 11, PO Box 434, Gothenburg 40530, Sweden
    Am J Physiol Cell Physiol 297:C140-51. 2009
    ..we investigate the cellular localization, regulation, and possible function of two IL-6 receptors (IL-6R alpha and gp130) in mouse and human fallopian tubes in vivo...
  55. ncbi STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    T G Boulton
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 92:6915-9. 1995
    ..6 are related cytokines that initiate signaling by homodimerizing the signal-transducing receptor component gp130 or by heterodimerizing gp130 with a gp130-related receptor component...
  56. ncbi Requirement of gp130 signaling for the AGM hematopoiesis
    Makiko Takizawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Exp Hematol 31:283-9. 2003
    ..b>gp130 is a signal transducing receptor component shared by all the IL-6 family cytokines, whose gene ablation in mouse ..
  57. ncbi Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3
    Christoph J Auernhammer
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich 81366, Germany
    Endocrinology 144:1202-10. 2003
    Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3) is a recently cloned gp130 cytokine, acting through the tripartite ciliary neurotrophic factor receptor (CNTFR) alpha/leukemia inhibitory factor receptor (LIFR)/gp130 ..
  58. ncbi Gp130 cytokines exert differential patterns of crosstalk in adipocytes both in vitro and in vivo
    Ursula A White
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:903-10. 2011
    Glycoprotein 130 (Gp130) cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival...
  59. ncbi Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells
    Y S Ho
    Graduate Institute of Biomedical Technology, Taipei Medical University, Taipei, Taiwan
    J Periodontal Res 44:550-6. 2009
    ..Although interleukin-6 (IL-6) regulates progression of atherosclerosis, little is known about the relationship of P. gingivalis fimbriae-dependent invasion to IL-6 regulation in endothelial cells...
  60. ncbi The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 105:3512-20. 2005
    ..homozygous for a knock-in mutation in the IL-6 cytokine family receptor signaling subunit glycoprotein (gp) 130 (gp130(Y757F/Y757F)) that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 ..
  61. ncbi Localization of gp130 in the developing and adult mouse cerebellum
    B K Ha
    Department of Neuroscience, The Ohio State University, 4068 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
    J Chem Neuroanat 19:129-41. 2000
    ..hematopoietic, and nervous system, which is believed to result from sharing of the signal transducing receptor gp130. IL-6 type cytokines and their binding receptors have been localized in the adult cerebellum...
  62. ncbi Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia
    Jason J Rose
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci Res 87:3098-106. 2009
    ..However, expression of a closely related gene, the interleukin-6 signal transducer or gp130 (IL-6st), showed no changes at 6 hr...
  63. ncbi Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver
    Dirk Graf
    Department of Gastroenterology, Hepatology, and Infectiology, Heinrich Heine University, Dusseldorf, Germany
    Hepatology 44:1206-17. 2006
    ..This inhibition was accompanied by GCDC-mediated downregulation of glycoprotein (gp) 130 expression, whereas gp130 and suppressor of cytokine signaling 3 messenger RNA and gp80 protein levels remained unaffected...
  64. ncbi The dependence on gp130 cytokines of axotomy induced neuropeptide expression in adult sympathetic neurons
    Beth A Habecker
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, Oregon 97239 3098, USA
    Dev Neurobiol 69:392-400. 2009
    ..to a family of cytokines with overlapping physiological effects and multimeric receptors containing the subunit gp130. Real-time PCR revealed large increases in the SCG after axotomy in mRNA for three members of this cytokine family,..
  65. ncbi Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells
    Anat Ben-Shlomo
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 88:858-63. 2003
    ..Normal human pituitary tissue expressed LIF, as well as the LIF receptor (LIFR) signaling subunits, gp130 and LIFR...
  66. ncbi Lack of glycoprotein 130/signal transducer and activator of transcription 3-mediated signaling in hepatocytes enhances chronic liver injury and fibrosis progression in a model of sclerosing cholangitis
    Werner Plum
    Department of Medicine III, University Hospital Aachen, Aachen, Germany
    Am J Pathol 176:2236-46. 2010
    ..The role of the interleukin-6/glycoprotein 130 (gp130) system in this context is still undefined...
  67. ncbi IL-6/IL-6 receptor system and its role in physiological and pathological conditions
    Masahiko Mihara
    Fuji Gotemba Research Laboratories, Product Research Department, Chugai Pharmaceutical Co Ltd, Gotemba, Japan
    Clin Sci (Lond) 122:143-59. 2012
    ..IL-6 exerts its biological activities through two molecules: IL-6R (IL-6 receptor) and gp130. When IL-6 binds to mIL-6R (membrane-bound form of IL-6R), homodimerization of gp130 is induced and a high-..
  68. ncbi Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas
    S De Breuck
    Cell Differentiation Unit, Vrije Universiteit Brussel Free University of Brussels, Laarbeeklaan 103, B 1090, Brussels, Belgium
    Diabetologia 49:108-16. 2006
    ..The aim of this study was to examine the expression and function of LIF in the pancreas...
  69. ncbi A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor
    Srinivas Chollangi
    Department of Bioengineering, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Biol Chem 287:32848-59. 2012
    ..based on structural similarities and their ability to activate the transmembrane receptor glycoprotein 130 (gp130)...
  70. ncbi A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor
    Cecile Ancey
    Institut fur Biochemie, Universitätsklinikum Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Biol Chem 278:16968-72. 2003
    ..of two different subunits, an alpha-subunit (IL-6Ralpha) that binds IL-6 with low affinity and a beta-subunit (gp130) that binds the IL-6.IL-6Ralpha complex with high affinity and as a result triggers intracellular signaling...
  71. ncbi Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia
    S Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 29:1024-8. 2008
    Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a ..
  72. ncbi IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    Ceri A Fielding
    Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:2189-95. 2008
    ..IL-6, which signals via the common receptor subunit gp130, represents a crucial checkpoint regulator of neutrophil trafficking during the inflammatory response by ..
  73. ncbi Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells
    Valerie A Morris
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195 7242, USA
    J Virol 82:8771-9. 2008
    ..infection activates many cell signaling pathways in endothelial cells and persistently activates STAT3 through the gp130 receptor, the common receptor of the interleukin 6 family of cytokines...
  74. ncbi Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes
    Ursula A White
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 283:22505-12. 2008
    Recent findings have implicated gp130 receptor ligands, particularly ciliary neurotrophic factor (CNTF), as potential anti-obesity therapeutics...
  75. ncbi STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
    Matthias Ernst
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    J Clin Invest 118:1727-38. 2008
    ..Using the gp130(Y757F/Y757F) mouse model of gastric cancer, which carries a mutated gp130 cytokine receptor signaling subunit that ..
  76. ncbi Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects
    P Fischer
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Br J Pharmacol 153:S414-27. 2008
    ..cytokines bind to plasma membrane receptor complexes containing the common signal transducing receptor chain gp130 that is ubiquitously expressed in most tissues including the heart...
  77. ncbi Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses
    T Ohtani
    Division of Molecular Oncology C7, Biomedical Research Center, Osaka University Graduate School of Medicine, Japan
    Immunity 12:95-105. 2000
    We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disrupted, by replacing the mouse gp130 gene with human gp130 mutant cDNAs...
  78. ncbi Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
    Uta Dierssen
    Internal Medicine III, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Biol Chem 283:9886-95. 2008
    Interleukin-6 (IL-6) via its signal transducer gp130 is an important mediator of liver regeneration involved in protecting from lipopolysaccharide (LPS)-induced liver injury after partial hepatectomy (PH)...
  79. ncbi Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)
    Tianbing Ding
    Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, 1125 MRB IV Light Hall, 2215 B Garland Avenue, Nashville, TN 37232 0656, USA
    Reproduction 135:41-53. 2008
    ..We investigated whether or not the uterine expression patterns of Lif and its receptors, Lif-r and gp130, during the periimplantation period of pregnancy and its hormonal regulation in the ovariectomized hamster ..
  80. ncbi [Lipopolysaccharide-mediated regulation of interleukin-6 in cultured human detrusor smooth muscle cells]
    J Neuhaus
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Leipzig AoR, Liebigstrasse 20, 04103 Leipzig
    Urologe A 46:1193-7. 2007
    ..The aim of the study is to define IL-6 target gene regulation in cultivated human detrusor smooth muscle cells...
  81. ncbi Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis
    P Fischer
    Dept of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Basic Res Cardiol 102:279-97. 2007
    ..b>Gp130 receptor mediated signaling promotes cardiomyocyte survival, induces hypertrophy, modulates cardiac extracellular ..
  82. ncbi Differential stimulation-induced receptor localization in lipid rafts for interleukin-6 family cytokines signaling through the gp130/leukemia inhibitory factor receptor complex
    Martha D Port
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7750, USA
    J Neurochem 101:782-93. 2007
    ..CNTF) are cytokines which signal through receptor complexes that include the receptor subunits glycoprotein 130 (gp130) and the LIF receptor (LIFR), but CNTF also requires the non-signal transducing CNTF receptor (CNTFR) for binding...
  83. ncbi Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    T Jostock
    I Medizinische Klinik, Section Pathophysiologie, Johannes Gutenberg Universitat Mainz, Germany
    Eur J Biochem 268:160-7. 2001
    ..requires binding of the cytokine to its receptor (IL-6R) and subsequent homodimerization of the signal transducer gp130. The complex of IL-6 and soluble IL-6R (sIL-6R) triggers dimerization of gp130 and induces responses on cells that ..
  84. ncbi Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
    Christian Ehlting
    Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf, Germany
    J Immunol 178:2813-26. 2007
    The potential of some proinflammatory mediators to inhibit gp130-dependent STAT3 activation by enhancing suppressor of cytokine signaling (SOCS) 3 expression represents an important molecular mechanism admitting the modulation of the ..
  85. ncbi Structure of an extracellular gp130 cytokine receptor signaling complex
    D Chow
    Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305, USA
    Science 291:2150-5. 2001
    The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex...
  86. ncbi The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine
    H Plun-Favreau
    INSERM EMI 9928, CHU d Angers, 4 rue Larrey, 49033 Angers Cedex, France
    EMBO J 20:1692-703. 2001
    ..responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha ..
  87. ncbi Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases
    M Schaeffer
    Medizinische Klinik III, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, and Klinische Kooperationsgruppe Gentherapie, National Research Center for Health and Environment GSF, D 81377 Munich, Germany
    Mol Cell Biol 21:8068-81. 2001
    ..IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor beta-chain, gp130. Here we describe the identification of an "acidic" domain comprising amino acids 771 to 811 of gp130 as ..
  88. ncbi Raised expression of cytokine receptor gp130 subunit on peripheral lymphocytes of patients with active lupus. A useful tool for monitoring the disease activity?
    M de la Torre
    Nephrology Service, Hospital San Agustin, Aviles, Spain
    Lupus 18:216-22. 2009
    The glycoprotein gp130 is a signal traducing subunit with a membrane domain of the IL-6 receptor...
  89. ncbi Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice
    Fumio Tsuji
    Research and Development Center, Santen Pharmaceutical Co, Ltd, Ikoma shi, Nara, Japan
    BMC Musculoskelet Disord 10:23. 2009
    Knock-in mice (gp130F759) with a Y759F point mutation in gp130, a signal transducing receptor subunit shared by members of the IL-6 cytokine family, show sustained activation of STAT3, enhanced acute-phase or immune responses, and ..
  90. ncbi Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor
    Nina Adam
    Institute of Biochemistry, Christian Albrechts University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    J Virol 83:5117-26. 2009
    ..binds to the IL-6 receptor (IL-6R) and only subsequently associates with the signal transducing receptor subunit gp130, vIL-6 has been shown to directly bind to gp130 without the need of IL-6R...
  91. ncbi Molecular cloning and expression of an IL-6 signal transducer, gp130
    M Hibi
    Division of Immunology, Osaka University, Japan
    Cell 63:1149-57. 1990
    Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein, gp130, which associates with IL-6 receptor (IL-6-R)...
  92. ncbi The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17
    Catherine L Kennedy
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
    J Pathol 225:255-64. 2011
    ..To formally address this, we employed gp130(F/F) mice, which spontaneously develop gastric inflammation-associated tumours akin to human intestinal-type ..
  93. ncbi IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii
    Jonathan S Silver
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 187:350-60. 2011
    ..Paradoxically, these factors both signal through gp130, but little is known about how the signals downstream of gp130 are integrated to coordinate the immune response to ..
  94. ncbi Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice
    Kanji Yamaguchi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Lab Invest 91:609-18. 2011
    ..that blockade of interleukin-6 (IL-6)-STAT3 signaling ameliorated liver injury, although hepatic STAT3(-/-) or GP130(-/-) mice have been reported to develop severe liver injury, in a murine methionine choline deficient (MCD) diet-..
  95. ncbi Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11
    C Rodriguez
    Institut de Genetique Moleculaire de Montpellier, CNRS UMR 9942, France
    Cytogenet Cell Genet 70:64-7. 1995
    Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family...
  96. ncbi Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes
    Y Wang
    Department of Cell Biology, University of Alabama at Birmingham 35294
    Mol Biol Cell 5:819-28. 1994
    ..Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit...
  97. ncbi A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis
    Zsuzsanna Pal
    Center for Molecular Neurology, Department of Neurology, Semmelweis University, Budapest, Hungary
    J Neuroimmunol 229:107-11. 2010
    ..Pathway analysis revealed interaction between LGALS1 and IL2Rβ suggesting a role of these proteins in this rare disease...
  98. ncbi Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes
    Yibin Xu
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 285:21214-8. 2010
    b>gp130 is the shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines...
  99. ncbi IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
    M Murakami
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Science 260:1808-10. 1993
    ..functions of interleukin-6 (IL-6) are mediated through a signal-transducing component of the IL-6 receptor, gp130, which is associated with the ligand-occupied IL-6 receptor (IL-6R) protein...
  100. ncbi Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase
    V Giordano
    Department of Biochemistry and Biomedical Technology, Medical School, University Federico II, Naples, Italy
    J Immunol 158:4097-103. 1997
    ..ciliary neurotropic factor, and cardiotropin-1, all of which initiate signaling through a receptor-associated gp130. IL-6 induces homodimerization of gp130 and activates the Jak/STAT pathway of signal transduction...
  101. ncbi Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Transplantation 88:266-71. 2009
    ..Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN...

Research Grants70

  1. IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSION
    CHARLES O BRIEN; Fiscal Year: 2002
    ..Moreover, sex steroids inhibit the expression of IL-6 and its receptor signaling component, gp130, whereas both genes are up-regulated by PTH...
  2. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..Using chimeric GM-CSF- gp130 receptor transfections, the signaling mechanisms involved to transduce IL-6 effects will be explored...
  3. Interleukin-6 Expression and Function in Adipose Cells
    JOYCE HARP; Fiscal Year: 2005
    ..Using chimeric GM-CSF- gp130 receptor transfections, the signaling mechanisms involved to transduce IL-6 effects will be explored...
  4. Molecular & Genetic Determinants of Outcome in Breast Cancer
    Angela DeMichele; Fiscal Year: 2007
    ..We will utilize immunohistochemical staining to identify alterations in tumor receptors (IL-6R, gp130, Her2/neu, EGFR), apoptosis (via TUNEL, STAT-1, STAT-3, bcl-2), cell cycle control (via MIB-1, AKT, p27) and ..
  5. Studies of HHV-8 vIL-6 Function
    John Nicholas; Fiscal Year: 2007
    ..differences in signalling (STAT and MAPK) activated by endogenous IL-6 (hlL-6), that utilizes (IL-6R) and (gp130) receptor subunits, and vlL-6, that can signal through gpl30 alone...
  6. MOLECULAR BIOLOGY & FUNCTION OF PLATELET MEMBRANE GP130
    Peter Newman; Fiscal Year: 1990
    ..The purpose of the study is to characterize completely a newly described membrane glycoprotein, termed GP130, that we have identified in human platelets and umbilical vein endothelial cells...
  7. INHIBITION OF IL-6 AND STAT3 IN RHEUMATOID ARTHRITIS
    Lionel Ivashkiv; Fiscal Year: 2004
    ..signaling upstream of Stat3 activation and is relative specific for IL-6 and related cytokines that share the gp130 signaling subunit...
  8. REGULATION OF IL-6 EXPRESSION IN ASTROCYTES
    ETTY BENVENISTE; Fiscal Year: 2004
    ..made the novel observation that Oncostatin M (OSM), a member of the IL-6 family of cytokines that also utilizes gp130 for signaling, is a potent activator of IL-6 in astrocytes...
  9. Transplantation: Graft Cell Promotion of Rejection
    David Perkins; Fiscal Year: 2004
    ..Although IL-6 is produced within the graft, major increases in IL-6 receptor (both IL-6Ralpha and gp130) occur in the lymph node, but not within the graft...
  10. Inflammatory factors, genes and stress induced pressure natriuresis in youth
    Haidong Zhu; Fiscal Year: 2007
    ..is a multi- functional cytokine that acts through a receptor comprising two subunits, IL-6 receptor (IL-6R) and gp130 cytokine signal transducer (gp130), and releases C-reactive protein (CRP)...
  11. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
    ..LIF stimulates OPC proliferation by direct signaling through its receptor in OPCs by conditionally deleting the gp130 component of the LIF receptor in OPCs...
  12. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..Using a functional genomics-based approach, we have identified the gp130 cytokine interleukin-11 (IL-11) as an astrocyte-derived factor that has supportive effects on oligodendrocytes, ..
  13. REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI
    Yoshio Yamaoka; Fiscal Year: 2010
    ..the Src homology 2 domain of the Src homology 2 phosphatase (SHP-2) binding site on the IL-6 family co- receptor, gp130. In these mice, the signal transducer and activator of transcriptions (STATs) signaling is hyperactivated and SHP-..
  14. GLIAL REACTION TO ISCHEMIC BRAIN INJURY
    RICHARD KRAIG; Fiscal Year: 2009
    ..cytokines (IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-10), their receptors (IL-1R1, TNFR1, IL-6Ralpha/gp130, IFNgammaR, IL-10R), and related downstream phosphoprotein (kinases (ERK1/2, P38MAPK, JNK) and transcription ..
  15. GLIAL REACTION TO ISCHEMIC BRAIN INJURY
    Richard P Kraig; Fiscal Year: 2010
    ..cytokines (IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-10), their receptors (IL-1R1, TNFR1, IL-6Ralpha/gp130, IFNgammaR, IL-10R), and related downstream phosphoprotein (kinases (ERK1/2, P38MAPK, JNK) and transcription ..
  16. GLIAL REACTION TO ISCHEMIC BRAIN INJURY
    RICHARD KRAIG; Fiscal Year: 2009
    ..cytokines (IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-10), their receptors (IL-1R1, TNFR1, IL-6Ralpha/gp130, IFNgammaR, IL-10R), and related downstream phosphoprotein (kinases (ERK1/2, P38MAPK, JNK) and transcription ..
  17. Astrocyte regulation of CNS remyelination
    Gareth R John; Fiscal Year: 2010
    ..Using a functional genomics-based approach, we have identified the gp130 cytokine interleukin-11 (IL-11) as an astrocyte-derived factor that has supportive effects on oligodendrocytes, ..
  18. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..Our studies reveal a prominent role for IL-6 in driving Stat3 activation in breast cancer cell lines through the gp130/Jak pathway providing evidence for an IL-6/Stat3 autocrine/paracrine positive feedback loop in tumorigenesis...
  19. MAVS protein: A role of mitochondria in innate immunity and cardioprotection
    Toshitaka Yajima; Fiscal Year: 2010
    ..proteins other than RIG-I and MDA-5 under I/R injury and 2) The effect of MAVS on NF-:B, IRF3, IRF7, gp130, Akt and MAPK signaling pathway under I/R injury will also be determined. 3...
  20. ROLE OF VIL-6 IN PRIMARY EFFUSION LYMPHOMAS
    John Nicholas; Fiscal Year: 2004
    ..4) to undertake in vitro vIL-6-receptor binding assays using wild-type and specifically altered forms of gp130 and IL-6R to characterize the nature of and requirements for vIL-6-gp130/IL-6R associations...
  21. HUMAN HEMATOPOIETIC PRECURSOR CELLS
    Christopher Hogan; Fiscal Year: 2001
    ..Here growth factor combinations that induce signaling through gp130 and/or tyrosine kinase receptors, as well as the presence of stromal cell layers, will be assessed in order to ..
  22. STROMAL CYTOKINE SIGNALING AND BIOLOGICAL FUNCTIONS
    Yu Chung Yang; Fiscal Year: 2001
    ..be tested in this proposal: 1) Overexpression, antisense expression and mutations of SHP-2, JAKs/Stats, IRS and gp130 proteins will affect biological functions of IL-11; (2) Structural domain requirements for different signaling ..
  23. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2007
    ..oxygen fluctuations cause oxidative injury, cell apoptosis, and signaling through pathways downstream of the gp130 receptor subunit/transducing protein causing further dysregulation of VEGF isoforms (especially the pathologic ..
  24. Protein dynamics, entropy and function
    A Joshua Wand; Fiscal Year: 2010
    ..This will include the interaction of the Leukemia Inhibitory Factor and Oncostatin M cytokines with the GP130 receptor...