GNRHR

Summary

Gene Symbol: GNRHR
Description: gonadotropin-releasing hormone receptor
Alias: GNRHR1, GRHR, HH7, LHRHR, LRHR, gnRH receptor, gnRH-R, gonadotropin-releasing hormone (type 1) receptor 1, leutinizing hormone releasing horomone receptor, leutinizing-releasing hormone receptor, luliberin receptor, type I GnRH receptor
Species: human

Top Publications

  1. ncbi A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor
    N de Roux
    INSERM unité 135, Institut Fédératif de Recherche 21, Hopital de Bicetre, Le Kremlin Bicetre, France
    N Engl J Med 337:1597-602. 1997
  2. ncbi Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism
    L C Layman
    Nat Genet 18:14-5. 1998
  3. ncbi The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred
    N de Roux
    INSERM U 135 et Laboratoire d Hormonologie et Biologie Moléculaire, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Clin Endocrinol Metab 84:567-72. 1999
  4. ncbi Molecular genetic analysis of normosmic hypogonadotropic hypogonadism in a Turkish population: identification and detailed functional characterization of a novel mutation in the gonadotropin-releasing hormone receptor gene
    A Kemal Topaloglu
    Division of Paediatric Endocrinology and Metabolism, Cukurova University, Faculty of Medicine, Adana, Turkey
    Neuroendocrinology 84:301-8. 2006
  5. ncbi Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction
    E M Costa
    Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular LIM 42, da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo 01060 970, Brazil
    J Clin Endocrinol Metab 86:2680-6. 2001
  6. ncbi Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function
    Gregoy Y Bedecarrats
    Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada
    Semin Reprod Med 25:368-78. 2007
  7. ncbi Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor
    Zhi Liang Lu
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Biol Chem 282:17921-9. 2007
  8. ncbi The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor
    N Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:2470-5. 2001
  9. ncbi Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism
    Beate Karges
    INSERM, U 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, Le Kremlin Bicetre, 94270 Paris, France
    J Clin Endocrinol Metab 88:1873-9. 2003
  10. ncbi Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration
    P Caron
    Service d Endocrinologie et Maladies Métaboliques, CHU Rangueil, Toulouse, France
    J Clin Endocrinol Metab 84:990-6. 1999

Research Grants

  1. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    TORRANCE M NETT; Fiscal Year: 2010
  2. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2010
  3. Molecular Analysis of GnRH Action
    Mark Roberson; Fiscal Year: 2009
  4. Molecular Analysis of GnRH Action
    Mark Roberson; Fiscal Year: 2009
  5. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2010
  6. REGULATION OF GNRH RECEPTOR GENE EXPRESSION
    Colin Clay; Fiscal Year: 2004
  7. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2009
  8. MOLECULAR CHARACTERIZATION OF GNRH RECEPTORS
    SHAM KAKAR; Fiscal Year: 2001
  9. GnRH Receptor Signaling Specificity
    Stuart Sealfon; Fiscal Year: 2005
  10. Cytotoxic Gonadotropin Releasing Hormone Derivatives
    L Glode; Fiscal Year: 2003

Detail Information

Publications180 found, 100 shown here

  1. ncbi A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor
    N de Roux
    INSERM unité 135, Institut Fédératif de Recherche 21, Hopital de Bicetre, Le Kremlin Bicetre, France
    N Engl J Med 337:1597-602. 1997
  2. ncbi Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism
    L C Layman
    Nat Genet 18:14-5. 1998
  3. ncbi The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred
    N de Roux
    INSERM U 135 et Laboratoire d Hormonologie et Biologie Moléculaire, Hopital de Bicetre, Le Kremlin Bicetre, France
    J Clin Endocrinol Metab 84:567-72. 1999
    ..endocrinological studies were performed in the three affected kindred of a family carrying mutations of the GnRH receptor gene...
  4. ncbi Molecular genetic analysis of normosmic hypogonadotropic hypogonadism in a Turkish population: identification and detailed functional characterization of a novel mutation in the gonadotropin-releasing hormone receptor gene
    A Kemal Topaloglu
    Division of Paediatric Endocrinology and Metabolism, Cukurova University, Faculty of Medicine, Adana, Turkey
    Neuroendocrinology 84:301-8. 2006
    ..Currently known mutations account for less than 15% of cases with normosmic hypogonadotropic hypogonadism (nIHH). The objective of the study was to identify novel hereditary associations in the pathogenesis of nIHH...
  5. ncbi Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction
    E M Costa
    Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular LIM 42, da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo 01060 970, Brazil
    J Clin Endocrinol Metab 86:2680-6. 2001
    Several point mutations in the GnRH receptor gene have been described in an autosomal recessive form of congenital isolated hypogonadotropic hypogonadism (HH)...
  6. ncbi Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function
    Gregoy Y Bedecarrats
    Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada
    Semin Reprod Med 25:368-78. 2007
    ..from clinical studies, this review summarizes the overall structure-function relationships of the human GnRH receptor, with an emphasis on the impact of naturally occurring mutations...
  7. ncbi Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor
    Zhi Liang Lu
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    J Biol Chem 282:17921-9. 2007
    ..occurring gonadotropin-releasing hormones (GnRHs) from different species in the single functional human GnRH receptor. We found that the highly variable amino acids in position 8 of the naturally occurring isoforms of GnRH play ..
  8. ncbi The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor
    N Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:2470-5. 2001
    Mutations in the GnRH receptor (GnRH-R) gene have been reported to cause idiopathic hypogonadotropic hypogonadism (IHH)...
  9. ncbi Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism
    Beate Karges
    INSERM, U 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, Le Kremlin Bicetre, 94270 Paris, France
    J Clin Endocrinol Metab 88:1873-9. 2003
    Mutations of the GnRH receptor have been recognized as a cause of familial gonadotropin deficiency...
  10. ncbi Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration
    P Caron
    Service d Endocrinologie et Maladies Métaboliques, CHU Rangueil, Toulouse, France
    J Clin Endocrinol Metab 84:990-6. 1999
    ..three siblings with isolated hypogonadotropic hypogonadism caused by compound heterozygote mutations in the GnRH receptor gene. The disorder was transmitted as an autosomal recessive trait...
  11. ncbi The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter
    Anne Granger
    Physiologie de l Axe Gonadotrope, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7079, Physiologie et Physiopathologie, Universite Pierre et Marie Curie PARIS6, 4 place Jussieu, 75252 Paris Cedex 05, France
    Mol Endocrinol 20:2093-108. 2006
    The GnRH receptor (GnRH-R) plays a central role in mammalian reproductive function throughout adulthood. It also appears as an early marker gene of the presumptive gonadotrope lineage in developing pituitary...
  12. pmc A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia
    Lin Lin
    Institute of Child Health and Department of Medicine, University College London, UK
    J Clin Endocrinol Metab 91:5117-21. 2006
    The GnRH receptor plays a central role in regulating gonadotropin synthesis and release, and several mutations in the GNRHR gene have been reported in patients with idiopathic or familial forms of isolated hypogonadotropic hypogonadism (..
  13. ncbi Novel homozygous splice acceptor site GnRH receptor (GnRHR) mutation: human GnRHR "knockout"
    L F G Silveira
    Department of Medicine, Royal Free Hospital and University College Medical School, Pond Street, London, UK
    J Clin Endocrinol Metab 87:2973-7. 2002
    Mutations in the GnRH receptor (GnRHR) have been shown to be responsible for a significant number of autosomic recessive and, less commonly, sporadic cases of idiopathic hypogonadotropic hypogonadism...
  14. ncbi The gonadotropin-releasing hormone (GnRH)-1 gene, the GnRH receptor gene, and their promoters in patients with idiopathic hypogonadotropic hypogonadism with or without resistance to GnRH action
    George A Vagenakis
    Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Rio, Greece
    Fertil Steril 84:1762-5. 2005
    ..The Pro146Ser mutation was identified in the gonadotropin-releasing hormone receptor (GnRHR) gene in two sisters as well as in their mother, and one polymorphism in the GnRH1 gene (the Trp16Ser) was ..
  15. ncbi Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor
    F P Pralong
    Department of Medicine, University Hospital, Lausanne, Switzerland
    J Clin Endocrinol Metab 84:3811-6. 1999
    ..This patient bore a novel point mutation (T for A) at codon 168 of the gene encoding the GnRH receptor (GnRH-R), resulting in a serine to arginine change in the fourth transmembrane domain of the receptor...
  16. ncbi Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site
    Guadalupe Maya-Nunez
    Research Unit in Developmental Biology, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, 06725 Mexico
    J Clin Endocrinol Metab 87:2144-9. 2002
    GnRH regulates the synthesis and release of pituitary gonadotropins. Mutations in the human GnRH receptor (hGnRHR) gene have been reported in families with hypogonadotropic hypogonadism...
  17. ncbi A new compound heterozygous mutation of the gonadotropin-releasing hormone receptor (L314X, Q106R) in a woman with complete hypogonadotropic hypogonadism: chronic estrogen administration amplifies the gonadotropin defect
    M L Kottler
    Endocrinologie Cellulaire et Moleculaire de la Reproduction, Centre National de la Recherche Scientifique, Universite Paris VI, France
    J Clin Endocrinol Metab 85:3002-8. 2000
    We describe a woman with complete hypogonadotropic hypogonadism and a new compound heterozygous mutation of the GnRH receptor (GnRHR) gene...
  18. ncbi A case of complete hypogonadotropic hypogonadism with a mutation in the gonadotropin-releasing hormone receptor gene
    Sławomir Wolczynski
    Department of Gynecological Endocrinology, Medical University, Bialystok, Poland
    Fertil Steril 79:442-4. 2003
    To screen for mutations in the GnRH receptor gene in a case of complete hypogonadotropic hypogonadism (HH) with GnRH resistance.
  19. pmc Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism
    Guadalupe Maya-Nunez
    Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico D F, Mexico
    Mol Cell Endocrinol 337:16-23. 2011
    ..mechanisms whereby the Thr104Ile and Tyr108Cys mutations in the gonadotropin-releasing hormone receptor (GnRHR) gene cause hypogonadotropic hypogonadism in humans are unknown...
  20. doi Screening of autosomal gene deletions in patients with hypogonadotropic hypogonadism using multiplex ligation-dependent probe amplification: detection of a hemizygosis for the fibroblast growth factor receptor 1
    Ericka Barbosa Trarbach
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42 da Disciplina de Endocrinologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 72:371-6. 2010
    ..Therefore, it remains to be determined whether patients without detected point mutation carried a heterozygous deletion of one or more exons...
  21. ncbi A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene
    D Soderlund
    Research Unit in Developmental Biology, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, D F, Mexico
    Clin Endocrinol (Oxf) 54:493-8. 2001
    Mutations in the GnRH receptor (GnRH-R) gene cause hypogonadotrophic hypogonadism. Here, we present the molecular studies of the GnRH-R gene in three families with isolated hypogonadotrophic hypogonadism.
  22. pmc Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?
    Stephen P Armstrong
    Laboratories for Integrative Neuroscience and Endocrinology, Department of Clinical Science at South Bristol, University of Bristol, Whitson Street, Bristol BS1 3NY
    J Biol Chem 284:35746-57. 2009
    ..This together with the lack of desensitization of translocation responses suggests that NFAT may mediate GnRH action but is not a genuine decoder of GnRH pulse frequency...
  23. ncbi An activator protein 1-like motif mediates 17beta-estradiol repression of gonadotropin-releasing hormone receptor promoter via an estrogen receptor alpha-dependent mechanism in ovarian and breast cancer cells
    Chi Keung Cheng
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada V6H 3V5
    Mol Endocrinol 17:2613-29. 2003
    Although it is recognized that estrogen is one of the most important regulators of GnRH receptor (GnRHR) gene expression, the mechanism underlying the regulation at the transcriptional level is unknown...
  24. ncbi Locally expressed LHRH receptors mediate the oncostatic and antimetastatic activity of LHRH agonists on melanoma cells
    Roberta M Moretti
    Department of Endocrinology, University of Milano, Milano 20133, Italy
    J Clin Endocrinol Metab 87:3791-7. 2002
    ..These receptors might also be considered as a possible molecular target for a hormone-based therapeutic approach to this tumor...
  25. ncbi Cloning and characterization of the human GnRH receptor
    L Chi
    Fishberg Research Center in Neurobiology, Mount Sinai School of Medicine, New York, NY 10029
    Mol Cell Endocrinol 91:R1-6. 1993
    A cDNA encoding the human GnRH receptor (GnRHR) has been cloned and functionally expressed in both Xenopus oocytes and COS-1 cells...
  26. ncbi The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294
    Mol Cell Endocrinol 106:145-9. 1994
    ..Primers were selected from the human pituitary GnRH receptor cDNA sequence to amplify the open reading frame and parts of its 5' and 3'-untranslated sequences...
  27. ncbi Oct-1 is involved in the transcriptional repression of the gonadotropin-releasing hormone receptor gene
    Chi Keung Cheng
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada V6H 3V5
    Endocrinology 143:4693-701. 2002
    Previous deletion analysis of the 5'-flanking region of human GnRH receptor (GnRHR) gene has revealed a powerful negative regulatory element (NRE) located between nucleotide -1017 and -771...
  28. ncbi The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans
    Patrizia Limonta
    Institute of Endocrinology, Center for Endocrinological Oncology, Via Balzaretti 9, 20133, Milano, Italy
    Front Neuroendocrinol 24:279-95. 2003
    ..A receptor specific for GnRH-II (type II GnRH receptor) has been identified in non-mammalian vertebrates as well as in primates, but not yet in humans...
  29. ncbi Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect
    Shaun P Brothers
    Division of Neuroscience, Oregon National Primate Research Center and Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Mol Endocrinol 18:1787-97. 2004
    The GnRH receptor (GnRHR) is a heptahelical G protein-coupled receptor found in the plasma membrane of pituitary gonadotropes...
  30. ncbi The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism
    Balasubramanian Bhagavath
    Division of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia, USA
    Fertil Steril 84:951-7. 2005
    To determine the prevalence of GNRH receptor (GNRHR) gene mutations in a large cohort of patients with idiopathic hypogonadotropic hypogonadism (IHH).
  31. ncbi Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants
    Paul E Knollman
    Division of Neuroscience and Reproductive Biology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Biol Chem 280:24506-14. 2005
    ..mouse mutants exert a DN effect on rat (r) WT sequence) but, unlike human or mouse, escapes the DN effect of GnRH receptor (Gn-RHR) mutants because rGnRHR mutants route to the plasma membrane with higher efficiency than mouse or ..
  32. ncbi Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timing
    Ines L Sedlmeyer
    Division of Endocrinology and Genetics, Department of Medicine, Children s Hospital, Hravard Medical School, Boston, MA 02115, USA
    J Clin Endocrinol Metab 90:1091-9. 2005
    Because GnRH and its receptor (GnRHR) are pivotal regulators of the reproductive endocrine axis and mutations in GNRHR lead to hypogonadotropic hypogonadism, we investigated whether genetic variation in GNRHR or GNRH1 affects pubertal ..
  33. pmc Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor
    Paul E Knollman
    Divisions of Neuroscience and Reproductive Biology, ONPRC OHSU, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
    Arch Biochem Biophys 477:92-7. 2008
    The GnRH receptor is coupled to G proteins of the families G(q) and G(11). G(q) and G(11) coupling leads to intracellular signaling through the phospholipase C pathway. GnRHR coupling to other G proteins is controversial...
  34. ncbi Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression
    Shaun P Brothers
    Division of Neuroscience and Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Mol Endocrinol 37:479-88. 2006
    ..Only the human receptor showed reduced signaling because it had fewer spare receptors compared with the rat GnRHR, allowing calnexin to affect signaling...
  35. ncbi Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama, Birmingham 35294
    Biochem Biophys Res Commun 189:289-95. 1992
    ..Therapeutically, the human pituitary GnRH receptor is the target of agonists used in the suppression of prostate cancer...
  36. pmc Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines
    Ann R Finch
    Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    J Endocrinol 196:353-67. 2008
    ..XGnRHR- or mouse GnRHR-mediated) stimulation of [(3)H]inositol phosphate accumulation and the hGnRHR-mediated reduction in cell number...
  37. ncbi A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 19:972-81. 2005
    ..determined that the N-ethyl-N-nitrosourea-induced lesion is in the third transmembrane domain of the GnRH receptor gene (Gnrhr)...
  38. ncbi Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay
    J C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 84:4497-500. 1999
    ..forms of hypogonadotropic hypogonadism (HH) are clearer, following the description of mutations in the genes KAL, GNRHR, and PROP1. Mutations in another gene, DAX1 (AHC), cause X-linked adrenal hypoplasia congenita and HH...
  39. ncbi Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro
    U B Kaiser
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endocrinology 138:1224-31. 1997
    ..b>GnRH receptor (GnRHR) mRNA levels also were increased by GnRH at all pulse frequencies and were stimulated maximally at a ..
  40. ncbi Transforming growth factor-beta modulates inhibin A bioactivity in the LbetaT2 gonadotrope cell line by competing for binding to betaglycan
    Jean Francois Ethier
    Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Mol Endocrinol 16:2754-63. 2002
    Activin stimulates expression of GnRH receptor (GnRHR) and FSH beta-subunit in gonadotropes. Inhibin antagonizes activin actions on the gonadotropes, but its molecular mechanism of action remains poorly understood...
  41. doi Expression of type I GNRH receptor and in vivo and in vitro GNRH-I effects in corpora lutea of pseudopregnant rabbits
    Massimo Zerani
    Scuola di Scienze mediche veterinarie, Universita di Camerino, 62024 Matelica, Italy
    J Endocrinol 207:289-300. 2010
    The expression of type I GNRH receptor (GNRHR-I) and the direct role of GNRH-I on corpora lutea (CL) function were studied in the pseudopregnant rabbit model...
  42. doi Development of novel 68Ga- and 18F-labeled GnRH-I analogues with high GnRHR-targeting efficiency
    Margret Schottelius
    Nuklearmedizinische Klinik and Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 19:1256-68. 2008
    ..lines using [(125)I]Triptorelin (D-Trp(6)-GnRH-I) as the standard radioligand revealed a very low level of GnRH receptor expression on the cell surface...
  43. pmc Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors
    Ann R Finch
    Univ of Bristol, Laboratory for Integrative Neuroscience, Bristol, BS1 3NY, UK
    Am J Physiol Cell Physiol 297:C591-600. 2009
    ..Sustained stimulation desensitizes GnRH receptor (GnRHR)-mediated gonadotropin secretion, and this underlies agonist use in hormone-dependent cancers...
  44. doi Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor
    Zvi Naor
    Department of Biochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Front Neuroendocrinol 30:10-29. 2009
    ..The interaction of GnRH with its cognate type I receptor (GnRHR) in pituitary gonadotropes results in the activation of Gq/G(11), phospholipase Cbeta (PLCbetaI), PLA(2), and PLD...
  45. ncbi c-Jun N-terminal kinase activation of activator protein-1 underlies homologous regulation of the gonadotropin-releasing hormone receptor gene in alpha T3-1 cells
    Buffy S Ellsworth
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Endocrinology 144:839-49. 2003
    ..GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR ..
  46. ncbi Ability of luteinizing hormone releasing hormone-Pseudomonas aeruginosa exotoxin 40 binding to LHRH receptor on human liver cancer cells
    Shou Liang Gong
    Radiobiology Research Unit of Ministry of Public Health, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
    World J Gastroenterol 10:2870-3. 2004
    To explore the ability of recombinant toxin luteinizing hormone releasing hormone-Pseudomonas aeruginosa exotoxin 40 (LHRH-PE40) and LHRH binding to LHRH receptor (LHRHR) on the membrane surface of human liver cancer HEPG cells.
  47. pmc Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis
    Kyeong Hoon Jeong
    Harvard Medical School, Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 150:3383-91. 2009
    The GnRH receptor (GnRHR) responds to pulsatile GnRH signals to coordinate pituitary gonadotropin synthesis and secretion. Previously, a 1...
  48. doi Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine disrupting chemicals
    Jae Sung Rhee
    Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul 133 791, South Korea
    Comp Biochem Physiol C Toxicol Pharmacol 147:357-65. 2008
    ..In this study, we have identified a GnRH receptor (GnRHR) gene from the hermaphroditic fish Kryptolebias marmoratus. K...
  49. pmc Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    BMC Evol Biol 6:103. 2006
    ..This study examined whether GPCRs orthologous to human gonadotropin-releasing hormone receptor (GnRHR) exist in C. elegans.
  50. pmc Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane
    W Lucca-Junior
    Division of Neuroscience and Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, ONPRC OHSU, Beaverton, Oregon, USA
    Braz J Med Biol Res 42:164-7. 2009
    ..aim of the present study was to evaluate the participation of ERp18 in gonadotropin-releasing hormone receptor (GnRHR) expression at the plasma membrane...
  51. ncbi E-box regulation of gonadotropin-releasing hormone (GnRH) receptor expression in immortalized gonadotrope cells
    D Resuehr
    Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306 4300, USA
    Mol Cell Endocrinol 278:36-43. 2007
    ..hormone GnRH (gonadotropin-releasing hormone) depends directly on the gonadotrope-specific expression of the GnRH receptor (GnRHR), a G-protein coupled transmembrane protein coded by the GnRHR gene...
  52. ncbi Gonadotropin-releasing hormone receptors
    Robert P Millar
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, United Kingdom
    Endocr Rev 25:235-75. 2004
    ..Although the predominant coupling of the type I GnRH receptor in the gonadotrope is through productive G(q) stimulation, signal transduction can occur via other G ..
  53. pmc Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor
    Rodrigo Ayala Yáñez
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Cell Biochem Funct 28:66-73. 2010
    ..CANX along with ERP-57 promotes the formation of disulfide bond bridges in nascent proteins. The human GnRH receptor (hGnRHR) is stabilized by two disulfide bond bridges (C(14)-C(200) and C(114)-C(196)), that, when broken, lead ..
  54. ncbi Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization
    Adam J Pawson
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:1415-22. 2008
    ..internalization but underwent robust agonist-dependent internalization, as did chimeras of the mammalian type I GnRH receptor with the cytoplasmic carboxyl-terminal tails of the catfish GnRH receptor or the rat TRH receptor...
  55. ncbi Evolution of GnRH ligand precursors and GnRH receptors in protochordate and vertebrate species
    Kevin Morgan
    MRC Human Reproductive Sciences Unit, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Gen Comp Endocrinol 139:191-7. 2004
    ..In contrast, only one functional GnRH receptor gene (the type I GnRH receptor) has been identified in humans and chimpanzees and a gene encoding a second receptor, homologous to a ..
  56. ncbi Dose-dependent switch in response of gonadotropin-releasing hormone (GnRH) neurons to GnRH mediated through the type I GnRH receptor
    Chun Xu
    Department of Internal Medicine, P O Box 800578, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 145:728-35. 2004
    ..Cultured embryonic and immortalized GnRH neurons express GnRH receptor type I (GnRHR-1), but expression has not been shown in adult GnRH neurons...
  57. ncbi Activin responsiveness of the murine gonadotropin-releasing hormone receptor gene is mediated by a composite enhancer containing spatially distinct regulatory elements
    Brian D Cherrington
    Colorado State University, Department of Biomedical Sciences Animal Reproduction and Biotechnology Laboratory, 1683 Campus Delivery, Ft Collins, Colorado 80523, USA
    Mol Endocrinol 19:898-912. 2005
    The promoters of mouse and rat GnRH receptor (GnRHR) genes differ markedly in regard to activin regulation. Activin stimulates the mouse GnRHR promoter, although it has no impact on that of the rat...
  58. ncbi Differential impact of intracellular carboxyl terminal domains on lipid raft localization of the murine gonadotropin-releasing hormone receptor
    Amy M Navratil
    Department of Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, Colorado 80523, USA
    Biol Reprod 74:788-97. 2006
    The mammalian type I GNRH receptor (GNRHR) is unique among G protein-coupled receptors (GPCRs) because of the absence of an intracellular C-terminus...
  59. pmc Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter
    Jean M Escudero
    Department of Biological and Health Sciences, Texas A and M University Kingsville, Kingsville, TX, USA
    J Ovarian Res 3:4. 2010
    ..The mechanism of Foxl2 regulation of this process has not been elucidated. Our approach to begin to understand Foxl2 function is through the identification of Foxl2 regulated genes in the ovary...
  60. pmc Fanconi anemia A is a nucleocytoplasmic shuttling molecule required for gonadotropin-releasing hormone (GnRH) transduction of the GnRH receptor
    Rachel Larder
    Medical Research Council, Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4JT, Scotland, United Kingdom
    Endocrinology 147:5676-89. 2006
    GnRH binds its cognate G protein-coupled GnRH receptor (GnRHR) located on pituitary gonadotropes and drives expression of gonadotropin hormones...
  61. doi Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals
    Alan J Stewart
    MRC Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, UK
    Neuroendocrinology 90:416-32. 2009
    The decapeptide hypothalamic-pituitary gonadotrophin-releasing hormone (GnRH)-I and the type I GnRH receptor drive the reproductive hormonal cascade in mammals by stimulating synthesis and secretion of luteinising hormone (LH) and ..
  62. ncbi Characterization of an intrinsically fluorescent gonadotropin-releasing hormone receptor and effects of ligand binding on receptor lateral diffusion
    S Nelson
    Department of Physiology, Colorado State University, Fort Collins 80523, USA
    Endocrinology 140:950-7. 1999
    The GnRH receptor (GnRHR) is a G protein-coupled receptor expressed by gonadotropes in the anterior pituitary gland...
  63. pmc Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists
    Ann R Finch
    Laboratory for Integrative Neuroscience, Department of Clinical Sciences at South Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    Mol Endocrinol 24:423-35. 2010
    ..Here we have quantified GnRHR by automated imaging in HeLa cells transduced with adenovirus expressing hemagglutinin-tagged GnRHR...
  64. ncbi Transcriptional regulation of the gonadotropin-releasing hormone receptor gene is mediated in part by a putative repressor element and by the cyclic adenosine 3',5'-monophosphate response element
    G Maya-Nunez
    Oregon Regional Primate Research Center, Beaverton 97006, USA
    Endocrinology 140:3452-8. 1999
    The levels of the GnRH receptor (GnRHR) and its messenger RNA depend on the pattern of administration of GnRH...
  65. ncbi Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists
    J E Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 43:784-96. 2000
    ..number of cyclic (4-10) and (5-8) and dicyclic (4-10/5-8) GnRH antagonists optimized for affinity to the rat GnRH receptor and in vivo antiovulatory potency...
  66. ncbi Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes
    J P Hapgood
    Department of Biochemistry, University of Stellenbosch, Matieland, South Africa
    J Neuroendocrinol 17:619-38. 2005
    Gonadotrophin-releasing hormone (GnRH), acting via its cognate GnRH receptor (GnRHR), is the primary regulator of mammalian reproductive function, and hence GnRH analogues are extensively used in the treatment of hormone-dependent ..
  67. doi Regulation of pituitary GnRH receptor and gonadotropin subunits by IGF1 and GnRH in prepubertal male coho salmon
    J Adam Luckenbach
    School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA 98195, USA
    Gen Comp Endocrinol 167:387-96. 2010
    ..of IGF1 alone or in combination with gonadotropin-releasing hormone (GnRH) on pituitary transcripts for GnRH receptor (GnRHR) variants, follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), and IGF, ..
  68. doi Functions of a GnRH receptor heterodimer of the ascidian, Ciona intestinalis
    T Sakai
    Suntory Institute for Bioorganic Research, Osaka, Japan
    Acta Biol Hung 59:241-3. 2008
    ..Recently, six GnRH forms (t-GnRH-3-8) and four GnRH receptor subtypes (Ci-GnRHR-1-4) were identified in the protochordate, Ciona intestinalis...
  69. ncbi Structure, expression, and cluster organization of genes encoding gonadotropin-releasing hormone receptors found in the neural complex of the ascidian Ciona intestinalis
    Takehiro Kusakabe
    Graduate School of Science, Himeji Institute of Technology, Harima Science Garden City, 3 2 1 Kouto, Kamigori, Ako gun, 678 1297 Hyogo, Japan
    Gene 322:77-84. 2003
    ..In the present study, two distinct homologues (Ci-GnRHR1 and Ci-GnRHR2) of the vertebrate GnRH receptor (GnRHR) were identified by cDNA cloning from the neural complex of the ascidian Ciona intestinalis...
  70. ncbi Induction of PER1 mRNA expression in immortalized gonadotropes by gonadotropin-releasing hormone (GnRH): involvement of protein kinase C and MAP kinase signaling
    James Olcese
    Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida 32306 4300, USA
    Chronobiol Int 23:143-50. 2006
    ..release of FSH and LH from the pituitary pars distalis via signaling pathways that are activated by the type I GnRH receptor (GnRH-R)...
  71. ncbi Structure of the mouse gonadotropin-releasing hormone receptor gene: variant transcripts generated by alternative processing
    W Zhou
    Fishberg Research Center for Neurobiology, Mount Sinai Medical Center, New York, NY 10029
    DNA Cell Biol 13:605-14. 1994
    The mouse gonadotropin-releasing hormone receptor (GnRHR) is unique among G-protein-coupled receptors in its lack of a putative intracellular carboxy-terminal domain...
  72. ncbi Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion
    Chien Lin Chen
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan, China
    Endocrine 31:311-20. 2007
    ..GnRH receptor reversed GnRH-I and GnRH-II-mediated invasion activities, suggesting that the same receptor, type I GnRH receptor, is essential for the effects of GnRH-I and GnRH-II in both OVCAR-3 and SKOV-3...
  73. doi Gonadotropin-releasing hormone receptor expression in endometrial cancer
    Yong Tark Jeon
    Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
    Int J Gynecol Pathol 28:19-22. 2009
    Several studies have previously reported the expression of the gonadotropin-releasing hormone receptor (GnRHr) in cases of endometrial cancer...
  74. ncbi The GnRH receptor gene is preferentially expressed in functioning gonadotroph adenomas and displays a Mae III polymorphism site
    M L Kottler
    Endocrinologie Cellulaire et Moleculaire de la Reproduction, URA CNRS 1449, Universite P and M Curie, Paris, France
    Clin Endocrinol (Oxf) 49:115-23. 1998
    Given the central role of the GnRH receptor (GnRHR) in the regulation of the gonadotrophin secretion, it might be implicated directly or indirectly in the pathogenesis of gonadotroph tumours.
  75. doi Regulation of gonadotropin-releasing hormone (GnRH) receptor-I expression in the pituitary and ovary by a GnRH agonist and antagonist
    Yaqin Mo
    Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou 510120, Guangdong, China
    Reprod Sci 17:68-77. 2010
    ..the effects of gonadotropin-releasing hormone agonist (GnRH-a) and antagonist (GnRH-ant) on the expression of GnRH receptor-I (GnRHR-I) in pituitary and ovaries in cyclophosphamide (CTX) chemotherapeutic rats and to investigate the ..
  76. ncbi GnRH receptor and androgen receptor status and outcome of advanced prostate carcinomas
    János Szabó
    Department of Urology, Central Hospital of the Hungarian Army, H 1134, Róbert k krt 44, Budapest, Hungary
    Anticancer Res 29:681-4. 2009
    ..a result of breaking the pituitary-gonadal axis, and partly the direct action on tumor cells expressing the GnRH receptor (GnRHR)...
  77. doi Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice
    Sheng Wu
    Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, Canada
    Endocrinology 151:1142-52. 2010
    Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor...
  78. ncbi Signaling complexes associated with the type I gonadotropin-releasing hormone (GnRH) receptor: colocalization of extracellularly regulated kinase 2 and GnRH receptor within membrane rafts
    Stuart P Bliss
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Mol Endocrinol 21:538-49. 2007
    Our previous work demonstrated that the type I GnRH receptor (GnRHR) resides exclusively and constitutively within membrane rafts in alphaT3-1 gonadotropes and that this association was necessary for the ability of the receptor to couple ..
  79. pmc Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase
    Marc Y Fink
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Endocrinol 24:1863-71. 2010
    The GnRH receptor (GnRHR), expressed at the cell surface of the anterior pituitary gonadotrope, is critical for normal secretion of gonadotropins LH and FSH, pubertal development, and reproduction...
  80. ncbi GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency
    Nicolas de Roux
    INSERM U690, Hopital Robert Debre, 48 Bld Serurier, 75019 Paris, France
    Best Pract Res Clin Endocrinol Metab 20:515-28. 2006
    ..GnRH resistance due to GnRH receptor (GnRHR) germ-line mutations was the first genetic alteration identified in patients with IHH...
  81. ncbi Trapping of a nonpeptide ligand by the extracellular domains of the gonadotropin-releasing hormone receptor results in insurmountable antagonism
    Trudy A Kohout
    Department of Endocrinology, Neurocrine Biosciences Inc, 12790 El Camino Real, San Diego, CA 92130, USA
    Mol Pharmacol 72:238-47. 2007
    ..Long-term suppression of the gonadotropin-releasing hormone receptor (GnRHR) is an important therapeutic approach for a number of sex hormone-dependent diseases...
  82. pmc A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor
    Takayoshi Kosugi
    Center for Molecular and Comparative Endocrinology, University of New Hampshire, 46 College Road, Durham, NH 3824, USA
    Gen Comp Endocrinol 166:498-503. 2010
    ..These results suggest that His(151) of the lamprey GnRH receptor-1 may play a critical role in the retention of a certain level of cell-surface expression for subsequent ..
  83. doi Genomic and nongenomic cross talk between the gonadotropin-releasing hormone receptor and glucocorticoid receptor signaling pathways
    Andrea Kotitschke
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag X3, Rondebosch 7700, South Africa
    Mol Endocrinol 23:1726-45. 2009
    The GnRH receptor (GnRHR), a member of the G protein-coupled receptor family, is a central regulator of reproductive function in all vertebrates...
  84. pmc Expression and localization of gonadotropin-releasing hormone receptor in the rat oviduct during pregnancy
    Anamika Sengupta
    Department of Physiology, Morehouse School of Medicine, 720 Westview Drive S W, Atlanta, GA 30310 1495, USA
    J Histochem Cytochem 56:25-31. 2008
    ..GnRH during pregnancy in rats, the present investigation aims at the study of the relative expression of GnRH receptor (GnRHR) mRNA by real-time PCR followed by immunolocalization of the peptide in the oviduct during pregnancy...
  85. ncbi Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor
    S Kraus
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
    Arch Med Res 32:499-509. 2001
    ..Here we review the intracellular signaling pathways mediated by the GnRH receptor (GnRHR)...
  86. ncbi Human gonadotropin-releasing hormone receptor-activated cellular functions and signaling pathways in extra-pituitary tissues and cancer cells (Review)
    Arturo Aguilar-Rojas
    Research Unit in Reproductive Medicine, IMSS, Unidad Médica de Alta Especialidad UMAE en Ginecología y Obstetricia No 4 Dr Luis Castelazo Ayala, sexto piso, 01090 México, D F, Mexico
    Oncol Rep 22:981-90. 2009
    Human gonadotropin-releasing hormone receptor (GnRHR) and its natural ligand human gonadotropin-releasing hormone (GnRH) were initially described as signaling complexes that play a key role in reproductive functions...
  87. doi Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues
    Lydia W T Cheung
    School of Biological Sciences, University of Hong Kong, China
    FEBS J 275:5479-95. 2008
    ..b>GnRH receptor (GnRHR) was found to be expressed in normal human reproductive tissues (e.g...
  88. pmc Adipokinetic hormone signaling through the gonadotropin-releasing hormone receptor modulates egg-laying in Caenorhabditis elegans
    Marleen Lindemans
    Functional Genomics and Proteomics Research Unit, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:1642-7. 2009
    ..In this study, the ligand for the GnRH receptor in the nematode Caenorhabditis elegans (Ce-GnRHR) was found using a bioinformatics approach...
  89. ncbi Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology
    Adam J Pawson
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4SB, UK
    Reproduction 126:271-8. 2003
    ..GnRH precursor genes, on chromosomes 8p11-p21 and 20p13, but only one conventional GnRH receptor subtype (type I GnRH receptor) encoded within the genome, on chromosome 4...
  90. ncbi Evidence that prostate gonadotropin-releasing hormone receptors mediate an anti-tumourigenic response to analogue therapy in hormone refractory prostate cancer
    V J Gnanapragasam
    Urology Research Group, Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    J Pathol 206:205-13. 2005
    ..b>GnRHR protein expression was first studied in a panel of prostate cancer cell lines...
  91. ncbi Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling
    Sharon Shacham
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    J Biol Chem 280:28981-8. 2005
    Type I gonadotropin-releasing hormone (GnRH) receptor (GnRHR) is unique among mammalian G-protein-coupled receptors (GPCRs) in lacking a C-terminal tail, which is involved in desensitization in GPCRs...
  92. pmc Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA
    Kyeong Hoon Jeong
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 24:6127-39. 2004
    The gonadotropin-releasing hormone receptor (GnRHR) is expressed primarily in the gonadotropes of the anterior pituitary...
  93. ncbi A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript
    R Millar
    MRC Molecular Reproductive Endocrinology Research Unit, University of Cape Town Medical School, Observatory 7925, South Africa
    J Endocrinol 162:117-26. 1999
    ..PCR of cDNA from a wide range of tissues revealed that intronic sequence equivalent to intron 2 of the Type I GnRH receptor was retained...
  94. ncbi Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression
    Jo Ann Janovick
    Oregon Health and Science University, Portland, OR 97239 3098, USA
    Endocrine 22:317-27. 2003
    Dominant negative effects of mutant gonadotropin-releasing hormone (GnRH) receptors (GnRHR; isolated from patients with idiopathic hypogonadotropic hypogonadism) on plasma membrane expression (PME) and function of the wt GnRHR were ..
  95. doi Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy
    Jo Ann Janovick
    Divisions of Reproductive and Developmental Science and Neuroscience and Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR 97006
    Proc Natl Acad Sci U S A 110:21030-5. 2013
    ..Pharmacoperones of the gonadotropin releasing hormone receptor (GnRHR) have efficacy in cell culture systems, and their cellular and biochemical mechanisms of action are known...
  96. ncbi Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target
    Jo Ann Janovick
    Oregon Regional Primate Research Center, Department of Physiology and Pharmacology, Oregon Health and Science University, 595 NW 185th Avenue, Beaverton, OR 97006, USA
    J Clin Endocrinol Metab 87:3255-62. 2002
    ..assessed by ligand binding and restoration of receptor coupling to effector) of five naturally occurring GnRH receptor (GnRHR) mutants (T(32)I, E(90)K, C(200)Y, C(279)Y, and L(266)R), identified from patients with ..
  97. ncbi Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor
    Lindsay Davidson
    Medical Research Council Human Reproductive Sciences Unit, Edinburgh Royal Infirmary, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, United Kingdom
    J Biol Chem 279:1980-93. 2004
    ..of classical G protein-coupled receptors (GPCRs) like the mammalian gonadotropin-releasing hormone receptor (GnRHR) typically stimulates heterotrimeric G protein molecules that subsequently activate downstream effectors...
  98. doi Rat Gnrhr promoter directs species-specific gene expression in the pituitary and testes of transgenic mice
    Muhammad Ishaq
    Universite Paris Diderot Paris 7, Sorbonne Paris Cité, biologie fonctionnelle et adaptative, EAC CNRS 4413, Physiologie de l Axe Gonadotrope, Batiment Buffon, case courier 7007, 4, rue MA Lagroua Weill Hallé, 75205 Paris Cedex 13, France
    J Mol Endocrinol 50:411-26. 2013
    The GnRH receptor (GnRHR) is expressed in several non-pituitary tissues, notably in gonads. However, mechanisms underlying the gonad-specific expression of Gnrhr are not well understood...
  99. pmc Responsiveness to a physiological regimen of GnRH therapy and relation to genotype in women with isolated hypogonadotropic hypogonadism
    Brent S Abel
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Reproductive Endocrine Sciences Center, Harvard Medical School, Boston, MA 02114, USA
    J Clin Endocrinol Metab 98:E206-16. 2013
    ..Most women with IHH ovulate with physiological GnRH replacement, implicating GnRH deficiency as the etiology. However, a subset does not respond normally, suggesting the presence of defects at the pituitary or ovary...
  100. ncbi Extrapituitary actions of GnRH antagonists: prospects for in vitro fertilization programs
    Gianna Gabriella Impicciatore
    Sezione di Scienze della Riproduzione, Dipartimento di Medicina e Scienze dell Invecchiamento, Facolta di Medicina e Chirurgia, Universita G D Annunzio, Chieti Pescara, Ospedale G Bernabeo, Contrada S Andrea, Ortona, Italy
    Curr Pharm Des 18:264-9. 2012
    ..GnRH-ant act by competitively binding GnRH receptors (GnRHr), leading to rapid pituitary suppression...
  101. doi Sertoli cell proliferation in the adult testis is induced by unilateral gonadectomy in African catfish
    Rudiger W Schulz
    Reproductive Biology Group, Division Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, The Netherlands
    Gen Comp Endocrinol 177:160-7. 2012
    ..However, expression of the gonadotropin-releasing hormone receptor gene gnrhr1 was significantly reduced after ULG, and Lh plasma levels were slightly elevated...

Research Grants69

  1. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    TORRANCE M NETT; Fiscal Year: 2010
    ..First, E2 enhances sensitivity of the pituitary by increasing GnRH receptor expression. Second and temporally delayed, it stimulates increased hypothalamic secretion of GnRH...
  2. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2010
    ..signaling molecules within the pituitary gland and how this compartmentalization affects signaling from of the GnRH receptor. Moreover, these studies will define the in vivo impact of genetic loss of key GnRH-regulated signaling ..
  3. Molecular Analysis of GnRH Action
    Mark Roberson; Fiscal Year: 2009
    ..signaling molecules within the pituitary gland and how this compartmentalization affects signaling from of the GnRH receptor. Moreover, these studies will define the in vivo impact of genetic loss of key GnRH-regulated signaling ..
  4. Molecular Analysis of GnRH Action
    Mark Roberson; Fiscal Year: 2009
    ..signaling molecules within the pituitary gland and how this compartmentalization affects signaling from of the GnRH receptor. Moreover, these studies will define the in vivo impact of genetic loss of key GnRH-regulated signaling ..
  5. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2010
    ..signaling molecules within the pituitary gland and how this compartmentalization affects signaling from of the GnRH receptor. Moreover, these studies will define the in vivo impact of genetic loss of key GnRH-regulated signaling ..
  6. REGULATION OF GNRH RECEPTOR GENE EXPRESSION
    Colin Clay; Fiscal Year: 2004
    ..Thus, the GnRH receptor (GnRHR) is the site that receives and mediates the primary stimulatory input to gonadotropes...
  7. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2009
    ..GnRH binds to its target, the GnRH receptor (GnRHR), on pituitary gonadotropes to affect the synthesis and intermittent release of the gonadotropins, ..
  8. MOLECULAR CHARACTERIZATION OF GNRH RECEPTORS
    SHAM KAKAR; Fiscal Year: 2001
    ..glucocorticoid, testosterone, GnRH, inhibin, TPA and cAMP, 3) To identify the cells in tumors expressing GnRH receptor using a monoclonal antibody, and 4) To determine the expression of GnRH and GnRHR in normal and tumor tissues...
  9. GnRH Receptor Signaling Specificity
    Stuart Sealfon; Fiscal Year: 2005
    ..the previous funding we have made considerable progress in elucidating the mechanism of action of the agonist-GnRH receptor complex at the molecular level...
  10. Cytotoxic Gonadotropin Releasing Hormone Derivatives
    L Glode; Fiscal Year: 2003
    ..prostate and breast cancer and to cancers not thought of as hormone-responsive which nevertheless express the GnRH receptor, such as ovarian, and possibly pancreatic and hepatocellular carcinoma...
  11. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..were identified in IHH patients, studies from our laboratory were instrumental in documenting mutations in the GNRHR gene, the first autosomal gene shown to be causative in IHH...
  12. Genetics of Delayed Puberty.
    LAWRENCE LAYMAN; Fiscal Year: 2007
    ..were identified in IHH patients, studies from our laboratory were instrumental in documenting mutations in the GNRHR gene, the first autosomal gene shown to be causative in IHH...
  13. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2010
    ..Although mutations in KAL1, FGFR1, and GNRHR genes account for 20-30% of cases and digenic disease has been reported in a few families, the molecular basis for ..
  14. Genes, OP Pesticides, and Reproductive Health
    Scott Venners; Fiscal Year: 2007
    ..of organophosphate pesticide and endocrine function including: CYP3A4, PON1, PON2, PON3, GSTM1, BCHE, ESR1, GnRHR LHCGR, and FSHR. Dr...
  15. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2002
    ..to understand the molecular mechanisms involved in the hormonal regulation and tissue-specific expression of the GnRHR gene...
  16. High Throughput Screening Assay Development for Pharmacoperones
    P Michael Conn; Fiscal Year: 2010
    ..These screens will also serve as prototypes for identification of other therapeutic molecules, and are important because existing screens would have missed potentially valuable drugs already present in chemical libraries. ..
  17. GONADOTROPIN-RELEASING HORMONE ACTION
    P Conn; Fiscal Year: 2007
    ..difficult to synthesize; GnRH is virtually impossible to denature), and availability of vectors encoding the GnRH receptor and many mutants (along with fluorescent probes) from a range of species and tissues...
  18. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2009
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  19. The role of FGF signaling in neuroendocrine control of reproduction
    Nelly Pitteloud; Fiscal Year: 2009
    ..hypogonadism [nIHH]) have provided unique insights into the genes controlling sexual maturation (KAL1, GNRHR, FGFR1, and GPR54)...
  20. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  21. The role of FGF signaling in neuroendocrine control of reproduction
    Nelly Pitteloud; Fiscal Year: 2010
    ..hypogonadism [nIHH]) have provided unique insights into the genes controlling sexual maturation (KAL1, GNRHR, FGFR1, and GPR54)...
  22. Somatostatin Receptor-Selective Agonists and Antagonists
    Jean Rivier; Fiscal Year: 2006
    ..abstract_text> ..