GNPDA2

Summary

Gene Symbol: GNPDA2
Description: glucosamine-6-phosphate deaminase 2
Alias: GNP2, SB52, glucosamine-6-phosphate isomerase 2, glcN6P deaminase 2, glucosamine-6-phosphate isomerase SB52
Species: human
Products:     GNPDA2

Top Publications

  1. Bauer F, Elbers C, Adan R, Loos R, Onland Moret N, Grobbee D, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90:951-9 pubmed publisher
    ..Our results suggest that these loci are not specifically associated with abdominal adiposity but more generally with obesity. We also found that some of the SNPs were associated with macronutrient-specific food intake. ..
  2. Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, et al. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. Obesity (Silver Spring). 2010;18:1212-7 pubmed publisher
    ..1,469 nondiabetic subjects for the single-nucleotide polymorphisms (SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752...
  3. Elks C, Loos R, Sharp S, Langenberg C, Ring S, Timpson N, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 2010;7:e1000284 pubmed publisher
    ..Eight variants that showed individual associations with childhood BMI (in/near: FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, and ETV5) were used to derive an "obesity-risk-allele score" comprising the total ..
  4. Wen W, Cho Y, Zheng W, Dorajoo R, Kato N, Qi L, et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012;44:307-11 pubmed publisher
    ..loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5...
  5. Kilpeläinen T, den Hoed M, Ong K, Grøntved A, Brage S, Jameson K, et al. Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. Am J Clin Nutr. 2011;93:851-60 pubmed publisher
    ..was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight...
  6. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao J, Sharp S, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes. 2010;59:2980-8 pubmed publisher
    ..Whereas the association of some variants may differ with age, the cumulative effect size is similar. ..
  7. Ng M, Tam C, So W, Ho J, Chan A, Lee H, et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95:2418-25 pubmed publisher
    ..We examined 14 associated single-nucleotide polymorphisms at 12 loci (NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15) in 605 healthy adults, 1087 healthy adolescents ..
  8. Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34 pubmed publisher
    ..We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant)...
  9. Renström F, Payne F, Nordström A, Brito E, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009;18:1489-96 pubmed publisher
    ..genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...

More Information

Publications53

  1. Li S, Zhao J, Luan J, Luben R, Rodwell S, Khaw K, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr. 2010;91:184-90 pubmed publisher
    ..These variants have cumulative effects, yet their predictive value for obesity risk is limited. ..
  2. Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet. 2009;54:727-31 pubmed publisher
    ..homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas ..
  3. Zeng C, Lin X, Peng C, Zhou L, You H, Shen J, et al. Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci. J Hum Genet. 2019;64:369-377 pubmed publisher
    ..05). Interestingly, the novel SNP rs1996023 is located at protein coding gene GNPDA2 (ccFDR = 1.28E-02), which has been reported to influence the risk of T2D and CO through central nervous system...
  4. Williams M, Almén M, Fredriksson R, Schioth H. What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci. 2012;69:3819-34 pubmed publisher
    ..33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, ..
  5. Graff M, Gordon Larsen P, Lim U, Fowke J, Love S, Fesinmeyer M, et al. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study. Diabetes. 2013;62:1763-7 pubmed publisher
    ..we examined evidence for heterogeneity in the associations of five established obesity risk variants (near FTO, GNPDA2, MTCH2, TMEM18, and NEGR1) with BMI across four distinct epochs of adulthood: 1) young adulthood (ages 18-25 years)..
  6. Lachén Montes M, González Morales A, Iloro I, Elortza F, Ferrer I, Gveric D, et al. Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling. Neurobiol Aging. 2019;73:123-134 pubmed publisher
    ..derangements in the modulation of secretagogin (SCGN), calcyclin-binding protein (CACYBP), and glucosamine 6 phosphate isomerase 2 (GNPDA2) between PD and AD...
  7. Kobae Y, Kawachi M, Saito K, Kikuchi Y, Ezawa T, Maeshima M, et al. Up-regulation of genes involved in N-acetylglucosamine uptake and metabolism suggests a recycling mode of chitin in intraradical mycelium of arbuscular mycorrhizal fungi. Mycorrhiza. 2015;25:411-7 pubmed publisher
    ..Altogether, data suggest the existence of an enhanced recycling mode of GlcNAc in IRM of AM fungi. ..
  8. Mitchell J, Hakonarson H, Rebbeck T, Grant S. Obesity-susceptibility loci and the tails of the pediatric BMI distribution. Obesity (Silver Spring). 2013;21:1256-60 pubmed publisher
    ..rs12970134), TMEM18 (rs2867125), BDNF (rs6265), TNNI3K (rs1514175), NRXN3 (rs10146997), SEC16B (rs10913469), and GNPDA2 (rs13130484)...
  9. Han X, Luo Y, Zhang X, Lv C, Sun X, Zhang X, et al. Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index. PLoS ONE. 2013;8:e56898 pubmed publisher
    ..Five genetic loci including rs2815752 near NEGR1, rs10938397 near GNPDA2, rs4074134 near BDNF, rs17782313 near MC4R and rs1084753 near KCTD15 were genotyped...
  10. Zhang M, Zhao X, Xi B, Shen Y, Wu L, Cheng H, et al. [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]. Zhonghua Yu Fang Yi Xue Za Zhi. 2014;48:776-83 pubmed
    ..GeneAmp 7900 sequence detection system (Applied Biosystems, Foster City, CA, USA) (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, FAIM2 rs7138803, BDNF rs6265, NPC1 rs1805081, PCSK1 rs6235, KCTD15 rs29941, BAT2 rs2844479, SEC16B ..
  11. Xi B, Zhao X, Shen Y, Wu L, Hotta K, Hou D, et al. Associations of obesity susceptibility loci with hypertension in Chinese children. Int J Obes (Lond). 2013;37:926-30 pubmed publisher
    ..034) and three SNPs were significantly associated with diastolic BP (DBP; GNPDA2 rs10938397: P=0.026; FAIM2 rs7138803: P=0.015; NPC1 rs1805081: P=0...
  12. Tomei S, Mamtani R, Al Ali R, Elkum N, Abdulmalik M, Ismail A, et al. Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population. J Transl Med. 2015;13:119 pubmed publisher
    ..3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013)...
  13. Luna Nácar M, Navarrete Perea J, Moguel B, Bobes R, Laclette J, Carrero J. Proteomic Study of Entamoeba histolytica Trophozoites, Cysts, and Cyst-Like Structures. PLoS ONE. 2016;11:e0156018 pubmed publisher
    ..In addition, we show that cysts express a high number of genes with unknown function, including four new, highly antigenic, possibly membrane-located proteins that could be targets of therapeutic and diagnostic usefulness. ..
  14. Felix J, Bradfield J, Monnereau C, van der Valk R, Stergiakouli E, Chesi A, et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet. 2016;25:389-403 pubmed publisher
    ..in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or ..
  15. Ouyang H, Zhang H, Li W, Liang S, Jebessa E, Abdalla B, et al. Identification, expression and variation of the GNPDA2 gene, and its association with body weight and fatness traits in chicken. Peerj. 2016;4:e2129 pubmed publisher
    Background. The GNPDA2 (glucosamine-6-phosphate deaminase 2) gene is a member of Glucosamine-6-phosphate (GlcN6P) deaminase subfamily, which encoded an allosteric enzyme of GlcN6P...
  16. Kaewsutthi S, Santiprabhob J, Phonrat B, Tungtrongchitr A, Lertrit P, Tungtrongchitr R. Exome sequencing in Thai patients with familial obesity. Genet Mol Res. 2016;15: pubmed publisher
    ..studies have identified several genes associated with obesity, including LEP, LEPR, POMC, PCSK1, FTO, MC3R, MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B, SIM1, and TNKS/MSRA...
  17. Miranda Lora A, Cruz M, Aguirre Hernandez J, Molina Díaz M, Gutierrez J, Flores Huerta S, et al. Exploring single nucleotide polymorphisms previously related to obesity and metabolic traits in pediatric-onset type 2 diabetes. Acta Diabetol. 2017;54:653-662 pubmed publisher
    ..9, 95% CI 1.2; 3.0); CADM2/rs13078807 (OR 2.2, 95% CI 1.2; 4.0); GNPDA2/rs10938397 (OR 2.2, 95% CI 1.4; 3.7); VEGFA/rs6905288 (OR 1.4, 95% CI 1.1; 2.1) and FTO/rs9939609 (OR 1...
  18. Manichaikul A, Wang X, Sun L, Dupuis J, Borczuk A, Nguyen J, et al. Genome-wide association study of subclinical interstitial lung disease in MESA. Respir Res. 2017;18:97 pubmed publisher
    ..genome-wide significance, including genes related to development (FOXP4), cell adhesion (ALCAM) and glycosylation (GNPDA2, GYPC, GFPT1 and FUT10)...
  19. Bandstein M, Voisin S, Nilsson E, Schultes B, Ernst B, Thurnheer M, et al. A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery. Obes Surg. 2016;26:2183-2189 pubmed publisher
    ..021) composed of seven BMI-associated SNPs (closest genes: MC4R, TMEM160, PTBP2, NUDT3, TFAP2B, ZNF608, MAP2K5, GNPDA2, and MTCH2) and of three WHR-associated SNPs (closest genes: HOXC13, LYPLAL1, and DNM3-PIGC)...
  20. Brandys M, Van Elburg A, Loos R, Bauer F, Hendriks J, van der Schouw Y, et al. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:695-699 pubmed publisher
    ..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN. ..
  21. Wang J, Mei H, Chen W, Jiang Y, Sun W, Li F, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int J Obes (Lond). 2012;36:542-7 pubmed publisher
    ..8±0.4 years, boys=877, girls=811) from Shanghai Children's Sleep Project. Eight SNPs within the NEGR1, TMEM18, GNPDA2, MTCH2, SH2B1, FTO, MC4R and KCTD15 genes were genotyped using matrix-assisted laser desorption/ionization-time of ..
  22. He M, Cornelis M, Franks P, Zhang C, Hu F, Qi L. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2010;30:327-32 pubmed publisher
    ..Four polymorphisms (rs9939609 [FTO], rs11084753 [KCTD15], rs10838738 [MTCH2], and rs10938397 [GNPDA2]) showed nominally significant associations with CVD...
  23. Orkunoglu Suer F, Harmon B, Gordish Dressman H, Clarkson P, Thompson P, Angelopoulos T, et al. MC4R variant is associated with BMI but not response to resistance training in young females. Obesity (Silver Spring). 2011;19:662-6 pubmed publisher
  24. Elks C, Loos R, Hardy R, Wills A, Wong A, Wareham N, et al. Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study. Am J Clin Nutr. 2012;95:1150-6 pubmed publisher
    ..birth cohort were genotyped for 11 genetic variants robustly associated with adult BMI (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, SEC16B, SH2B1, and MTCH2)...
  25. Graff M, Ngwa J, Workalemahu T, Homuth G, Schipf S, Teumer A, et al. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet. 2013;22:3597-607 pubmed publisher
    ..24 × 10?¹?), MC4R (P = 4.41 × 10?¹?), TNNI3K (P = 4.32 × 10?¹¹), SEC16B (P = 6.24 × 10??), GNPDA2 (P = 1.11 × 10??) and POMC (P = 4...
  26. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, et al. Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals. Diabetologia. 2011;54:1350-9 pubmed publisher
    ..reports) were replicated for 11 SNPs from the following ten loci in Japanese participants: SEC16B, TMEM18, GNPDA2, BDNF, MTCH2, BCDIN3D-FAIM2, SH2B1-ATP2A1, FTO, MC4R and KCTD15...
  27. Hong J, Shi J, Qi L, Cui B, Gu W, Zhang Y, et al. Genetic susceptibility, birth weight and obesity risk in young Chinese. Int J Obes (Lond). 2013;37:673-7 pubmed publisher
    ..05 in HapMap Han Chinese in Beijing, China. Six loci, including SEC16B, GNPDA2, BDNF, FTO, MC4R and TMEM160, were significantly associated with obesity risk, with odds ratio from 1.314 to 1.701...
  28. Paternoster L, Evans D, Nohr E, Holst C, Gaborieau V, Brennan P, et al. Genome-wide population-based association study of extremely overweight young adults--the GOYA study. PLoS ONE. 2011;6:e24303 pubmed publisher
    ..We also found strong evidence of association at the known TMEM18, GNPDA2, SEC16B, TFAP2B, SH2B1 and KCTD15 loci (p<0.001), and nominal association (p<0...
  29. Fu J, Li G, Li L, Yin J, Cheng H, Han L, et al. The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study. Oncotarget. 2017;8:93593-93607 pubmed publisher
    ..6×10-5), MC4R-rs2331841 (P=4.4×10-4), GNPDA2-rs16858082 (P = 3.4×10-4), PCSK1-rs261967 (P = 0...
  30. Dorajoo R, Blakemore A, Sim X, Ong R, Ng D, Seielstad M, et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 2012;36:159-63 pubmed publisher
    ..95 × 10(-7)). We further detected associations with nine other index obesity variants close to the MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B and TNKS/MSRA loci (meta-analysis P-values ranging from 3...
  31. Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, et al. Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. J Hum Genet. 2011;56:716-9 pubmed publisher
    ..single-nucleotide polymorphisms (SNPs): NEGR1 rs2815752, SEC16B rs10913469, TMEM18 rs6548238, ETV5 rs7647305, GNPDA2 rs10938397, BDNF rs6265 and rs925946, MTCH2 rs10838738, SH2B1 rs7498665, MAF rs1424233, and KCTD15 rs29941 and ..
  32. Sandholt C, Vestmar M, Bille D, Borglykke A, Almind K, Hansen L, et al. Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. PLoS ONE. 2011;6:e23531 pubmed publisher
    ..NEGR1 (rs2568958), ETV5 (rs7647305), BDNF (rs4923461, rs925946), SEC16B (rs10913469), FAIM2 (rs7138803), GNPDA2 (rs10938397), MTCH2 (rs10838738), BAT2 (rs2260000), NPC1 (rs1805081), MAF (rs1424233), and PTER (rs10508503) were ..
  33. Monda K, Chen G, Taylor K, Palmer C, Edwards T, Lange L, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45:690-6 pubmed publisher
    ..7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations. ..
  34. Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J Hum Genet. 2011;56:647-51 pubmed publisher
    ..obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
  35. Arreola R, Valderrama B, Morante M, Horjales E. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. FEBS Lett. 2003;551:63-70 pubmed
    ..These structural differences can be related to the kinetic and allosteric properties of both mammalian enzymes. ..
  36. Oikari S, Makkonen K, Deen A, Tyni I, Kärnä R, Tammi R, et al. Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis. Glycobiology. 2016;26:710-22 pubmed publisher
    ..enzymes: GNPDA1 siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increased GFAT1, and GFAT1 siRNA increased the expression of hyaluronan synthase 2 (HAS2)...
  37. Delahanty L, Pan Q, Jablonski K, Watson K, McCaffery J, SHULDINER A, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 2012;35:363-6 pubmed publisher
    ..We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss-inducing interventions (lifestyle and metformin) versus placebo...
  38. Lawlor D, Fraser A, Macdonald Wallis C, Nelson S, Palmer T, Davey Smith G, et al. Maternal and offspring adiposity-related genetic variants and gestational weight gain. Am J Clin Nutr. 2011;94:149-55 pubmed publisher
    ..nucleotide polymorphisms (SNPs; rs9939609 in FTO, rs17782313 near MC4R, rs6548238 near TMEM18, and rs10938397 near GNPDA2) with GWG in a pregnancy cohort in which women had detailed repeated assessment of GWG (median number of weight ..
  39. Cheung C, Tso A, Cheung B, Xu A, Ong K, Law L, et al. Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study. Eur J Endocrinol. 2011;164:381-8 pubmed publisher
    ..We have previously demonstrated that three obesity-susceptible single nucleotide polymorphisms (SNPs), rs10938397 (GNPDA2), rs8050136 (FTO) and rs17782313 (MC4R), were associated with obesity and waist circumference in cross-sectional ..
  40. Lim U, Wilkens L, Monroe K, Caberto C, Tiirikainen M, Cheng I, et al. Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies. Int J Cancer. 2012;131:E1038-43 pubmed publisher
    ..Twenty-four single nucleotide polymorphisms (SNPs) in 15 loci (BDNF, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MC4R, MSRA, MTCH2, NEGR1, NRXN3, SEC16B, SH2B1, TFAP2B and TMEM18) were genotyped in a case-..
  41. Coenen K, Karp S, Gesell S, Dietrich M, Morgan T, Barkin S. Genetic risk score does not correlate with body mass index of Latina women in a clinical trial. Clin Transl Sci. 2011;4:323-7 pubmed publisher
    ..A majority (83%) of participants had a BMI ?25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians...
  42. Mumby H, Elks C, Li S, Sharp S, Khaw K, Luben R, et al. Mendelian Randomisation Study of Childhood BMI and Early Menarche. J Obes. 2011;2011:180729 pubmed publisher
    ..DNA was genotyped for twelve BMI-associated common variants (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, MTCH2, SEC16B, FAIM2 and SH2B1), and for each individual a "BMI-increasing-allele-..
  43. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes. 2010;59:3085-9 pubmed publisher
    ..rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the ..
  44. Zhao J, Bradfield J, Zhang H, Sleiman P, Kim C, Glessner J, et al. Role of BMI-associated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans. Obesity (Silver Spring). 2011;19:2436-9 pubmed publisher
    ..nominal evidence for association with common childhood obesity, namely at the FTO, TMEM18, NRXN3, MC4R, SEC16B, GNPDA2, TNNI3K, QPCTL, and BDNF loci...