GNPDA1

Summary

Gene Symbol: GNPDA1
Description: glucosamine-6-phosphate deaminase 1
Alias: GNP1, GNPDA, GNPI, GPI, HLN, glucosamine-6-phosphate isomerase 1, GNPDA 1, glcN6P deaminase 1, oscillin
Species: human
Products:     GNPDA1

Top Publications

  1. Lin C, Lee H, Lee M, Pan S, Ke C, Chiu A, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..gene (c-MYC)-encoded MYC; glycolytic enzymes including hexokinase II (HK-II), glucose 6-phosphate isomerase (GPI), phosphofructokinase (PFK), and lactate dehydrogenase subunit A (LDHA); and hypoxia-inducible factors the HIF-1? ..
  2. Lin C, Liu L, Ou L, Pan S, Lin C, Wei Y. Role of mitochondrial function in the invasiveness of human colon cancer cells. Oncol Rep. 2018;39:316-330 pubmed publisher
    ..Moreover, SW620 cells displayed lower protein levels of hexokinase II (HK-II), glucose 6-phosphate isomerase (GPI) and lactate dehydrogenase (LDH), and lower lactate production rate, and expressed higher levels of EMT markers N-..
  3. Oertel W, Schulz J. Current and experimental treatments of Parkinson disease: A guide for neuroscientists. J Neurochem. 2016;139 Suppl 1:325-337 pubmed publisher
    ..is offered deep brain stimulation of the subthalamic nucleus (STN) or the internal part of the globus pallidus (GPi)...
  4. Clotet S, Soler M, Riera M, Pascual J, Fang F, Zhou J, et al. Stable Isotope Labeling with Amino Acids (SILAC)-Based Proteomics of Primary Human Kidney Cells Reveals a Novel Link between Male Sex Hormones and Impaired Energy Metabolism in Diabetic Kidney Disease. Mol Cell Proteomics. 2017;16:368-385 pubmed publisher
    ..glycolysis, N-acetylglucosamine metabolism and fatty acid β-oxidation, namely glucose-6-phosphate isomerase (GPI), glucosamine-6-phosphate-N-acetyltransferase 1 (GNPNAT1), and mitochondrial trifunctional protein subunit alpha (..
  5. LaRocca T, Stivison E, Hod E, Spitalnik S, Cowan P, Randis T, et al. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. MBio. 2014;5:e01251-14 pubmed publisher
    ..unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule...
  6. Tarailo Graovac M, Sinclair G, Stockler Ipsiroglu S, Van Allen M, Rozmus J, Shyr C, et al. The genotypic and phenotypic spectrum of PIGA deficiency. Orphanet J Rare Dis. 2015;10:23 pubmed publisher
    ..class A protein (PIGA) is one of the enzymes involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchor proteins, which function as enzymes, adhesion molecules, complement regulators and co-receptors in signal ..
  7. Realegeno S, Puschnik A, Kumar A, Goldsmith C, Burgado J, Sambhara S, et al. Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. J Virol. 2017;91: pubmed publisher
    ..including those involved in Golgi trafficking, glycosaminoglycan biosynthesis, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis...
  8. Oaks Z, Winans T, Caza T, Fernandez D, Liu Y, Landas S, et al. Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice. Arthritis Rheumatol. 2016;68:2728-2739 pubmed publisher
    ..Anticardiolipin (aCL) and anti-?2 -glycoprotein I (anti-?2 GPI) autoantibodies were measured by enzyme-linked immunosorbent assay in mice treated with rapamycin or mice treated ..
  9. Ramirez Garcia A, Pellon A, Buldain I, Antoran A, Arbizu Delgado A, Guruceaga X, et al. Proteomics as a Tool to Identify New Targets Against Aspergillus and Scedosporium in the Context of Cystic Fibrosis. Mycopathologia. 2018;183:273-289 pubmed publisher
    ..alkaline protease 2 (Alp2), Asp f 3 (putative peroxiredoxin pmp20), probable glycosidases Asp f 9/Crf1 and Crf2, GPI-anchored protein Ecm33, ?-1,3-glucanosyltransferase Gel4, conidial hydrophobin Hyp1/RodA, and secreted aspartyl ..

More Information

Publications149 found, 100 shown here

  1. Scharfstein J, Ramos P, Barral Netto M. G Protein-Coupled Kinin Receptors and Immunity Against Pathogens. Adv Immunol. 2017;136:29-84 pubmed publisher
    ..As inflammation persists, a GPI-linked carboxypeptidase M removes the C-terminal arginine from the primary kinin, converting the B2R agonist into a ..
  2. Abbasnia T, Asoodeh A, Habibi G, Haghparast A. Isolation and purification of glycosylphosphatidylinositols (GPIs) in the schizont stage of Theileria annulata and determination of antibody response to GPI anchors in vaccinated and infected animals. Parasit Vectors. 2018;11:82 pubmed publisher
    ..Then, the free GPIs of schizont stage and isolated GPI from cell membrane glycoproteins were purified by high performance liquid chromatography (HPLC) and confirmed by ..
  3. Park M, Hasenstein K. Oxygen dependency of germinating Brassica seeds. Life Sci Space Res (Amst). 2016;8:30-7 pubmed publisher
    ..Glycolysis and fermentation pathway-related genes, glucose phosphate isomerase (GPI), 6-phosphofructokinase (PFK), fructose 1,6-bisphosphate aldolase (ALD), glyceraldehyde-3-phosphate dehydrogenase (..
  4. Sanchez I, Balagué E, Matilla Dueñas A. Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3?-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1). Hum Mol Genet. 2016;25:4021-4040 pubmed publisher
    ..PKM-i1), citrate synthase (CS), glycerol-3-phosphate dehydrogenase 2 (GPD2), glucose-6-phosphate isomerase (GPI), alpha -: enolase (ENO1)], ATP synthesis [CS, Succinate dehydrogenase complex,subunit A (SDHA), ATP synthase ..
  5. Bacquin A, Bireau C, Tanguy M, Romanet C, Vernochet C, Dupressoir A, et al. A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. J Virol. 2017;91: pubmed publisher
    ..assay with the screening of a mouse cDNA library, we succeeded in identifying the glycosylphosphatidylinositol (GPI)-anchored membrane protein lymphocyte antigen 6E (Ly6e) as a candidate receptor for SynA...
  6. Cao Q, Ni Y, Cao D, Tian D, Yugo D, Heffron C, et al. Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection. J Virol. 2018;92: pubmed publisher
    ..with the porcine cytokine interleukin-15 (IL-15) or IL-18 gene fused to a glycosylphosphatidylinositol (GPI) modification signal that can anchor the cytokines to the cell membrane...
  7. Liu F, Li S, Liu G, Li F. Triosephosphate isomerase (TPI) facilitates the replication of WSSV in Exopalaemon carinicauda. Dev Comp Immunol. 2017;71:28-36 pubmed publisher
    ..which catalyzed upper steps of glycolysis to produce GAP, including hexokinase (HK), glucose-6-phosphate isomerase (GPI) and phosphofructokinase-1 (PFK-1), were significantly up-regulated at 24 and 27 hpi...
  8. Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, et al. KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells. Exp Hematol. 2019;: pubmed publisher
    ..1 (EPB41), EPB42, glutathione disulfide reductase (GSR), glucose phosphate isomerase (GPI), and ATPase phospholipid transporting 8A1 (ATP8A1)...
  9. Jahangiri A, Rasooli I, Gargari S, Owlia P, Rahbar M, Amani J, et al. An in silico DNA vaccine against Listeria monocytogenes. Vaccine. 2011;29:6948-58 pubmed publisher
    ..Addition of GPI anchor, myristoylation and ubiquitin signals or proline (P), glutamic acid (E), serine (S), threonine (T) (PEST)-..
  10. Ntege E, Arisue N, Ito D, Hasegawa T, Palacpac N, Egwang T, et al. Identification of Plasmodium falciparum reticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate. Vaccine. 2016;34:5612-5622 pubmed publisher
    ..in four recently reported novel blood-stage malaria vaccine candidate proteins: Rh5 interacting protein (PfRipr), GPI anchored micronemal antigen (PfGAMA), rhoptry-associated leucine zipper-like protein 1 (PfRALP1) and Duffy binding-..
  11. Yu M, Pisitkun T, Wang G, Shen R, Knepper M. LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells. Mol Cell Proteomics. 2006;5:2131-45 pubmed
    ..17 integral and glycosylphosphatidylinositol (GPI)-linked membrane proteins and 44 non-integral membrane proteins were identified...
  12. Kono S. Aceruloplasminemia. Curr Drug Targets. 2012;13:1190-9 pubmed
    ..In the central nervous system, a glycosylphosphatidylinositol (GPI)-anchored ceruloplasmin bound to the cell membranes of astrocytes was found to be the major isoform of this protein...
  13. Iwabuchi K. Gangliosides in the Immune System: Role of Glycosphingolipids and Glycosphingolipid-Enriched Lipid Rafts in Immunological Functions. Methods Mol Biol. 2018;1804:83-95 pubmed publisher
    ..in cell membranes of lipid rafts, which are lipid domains rich in GSLs, cholesterol, glycosylphosphatidylinositol (GPI)-anchored proteins and membrane-anchored signaling molecules (Pike, J Lipid Res 47(7):1597-1598, 2006)...
  14. Amor D, Stephenson S, Mustapha M, Mensah M, Ockeloen C, Lee W, et al. Pathogenic Variants in GPC4 Cause Keipert Syndrome. Am J Hum Genet. 2019;: pubmed publisher
    ..and in concomitant loss of functionally important N-linked glycosylation (Asn514) and glycosylphosphatidylinositol (GPI) anchor (Ser529) sites...
  15. Bloemen S, Wu X, Devreese K, de Laat B, Rand J, Vasovic L. Inverted erythrocyte membranes demonstrate ?2GPI-antiphospholipid antibody interactions and membrane crosslinking. Thromb Res. 2016;146:89-94 pubmed publisher
    ..Binding of ?2-glycoprotein I (?2GPI)-IgG immune complexes to iEMs was investigated with gel electrophoresis, western blot and flow cytometry...
  16. Yao X, Wu J, Lin M, Sun W, He X, Gowda C, et al. Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model. PLoS Pathog. 2016;12:e1005930 pubmed publisher
    ..connect several signaling pathways consisting of phagocytosis of iRBCs, recognition of parasite DNA/RNA (possibly GPI) by TLRs, elevated levels of CD40 and STING proteins, increased IFN-I production, and longer host survival time...
  17. Andemariam B, Adami A, Singh A, McNamara J, Secor E, Guernsey L, et al. The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Transl Res. 2015;166:254-68 pubmed publisher
    ..interleukin 5 (IL-5), IL-7, and chemokine (C-X-C motif) ligand (CXCL)1; and (3) lung tissue and hilar lymph node (HLN) had increased CD4+, CD8+, and regulatory T (Treg) cells...
  18. Das M, Bag A, Saha S, Ghosh A, Dey S, Das P, et al. Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells. BMC Cancer. 2016;16:152 pubmed publisher
    ..Here, we report that GAPDH is associated with glucose-6-phosphate isomerase (GPI) and pyruvate kinase M2 (PKM2) in Ehrlich ascites carcinoma (EAC) cells and also in 3-methylcholanthrene (3MC) ..
  19. Sahu P, Tomar R. The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum. J Biol Chem. 2019;294:3837-3852 pubmed publisher
    ..reticulum (ER) homeostasis and cell wall integrity by altering the sorting of glycosylphosphatidylinositol (GPI)-anchored proteins...
  20. Chang P, Zhang Q, Scharfenstein L, Mack B, Yoshimi A, Miyazawa K, et al. Aspergillus flavus GPI-anchored protein-encoding ecm33 has a role in growth, development, aflatoxin biosynthesis, and maize infection. Appl Microbiol Biotechnol. 2018;102:5209-5220 pubmed publisher
    Many glycosylphosphatidylinositol-anchored proteins (GPI-APs) of fungi are membrane enzymes, organization components, and extracellular matrix adhesins...
  21. Tucker H, Mahoney E, Chhetri A, Unger K, Mamone G, Kim G, et al. Deep brain stimulation of the ventroanterior and ventrolateral thalamus improves motor function in a rat model of Parkinson's disease. Exp Neurol. 2019;317:155-167 pubmed publisher
    ..PD situated in the basal ganglia; specifically, in the subthalamic nucleus (STN) and globus pallidus pars interna (GPi)...
  22. Francischetti I, Oliveira C, Ostera G, Yager S, Debierre Grockiego F, Carregaro V, et al. Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria. Arterioscler Thromb Vasc Biol. 2012;32:786-98 pubmed publisher
    ..We also demonstrated that Plasmodium falciparum glycosylphosphatidylinositol (Pf-GPI) induces tissue factor expression in ECs and cytokine production by dendritic cells...
  23. Gavriilaki E, Yuan X, Ye Z, Ambinder A, Shanbhag S, Streiff M, et al. Modified Ham test for atypical hemolytic uremic syndrome. Blood. 2015;125:3637-46 pubmed publisher
    ..to APC-activated serum due to deficiency of glycosylphosphatidylinositol- anchored complement regulatory proteins (GPI-AP). Here, we demonstrate that phosphatidylinositol-specific phospholipase C-treated EA...
  24. Shin D, Behura S, Severson D. Genome-Wide Transcriptome Profiling Reveals Genes Associated with Meiotic Drive System of Aedes aegypti. Insects. 2019;10: pubmed publisher
    ..on pathway analysis of these differentially expressed genes, it was observed that the glycosylphosphatidylinositol (GPI)-anchor biosynthesis pathway may play a role in the meiotic drive system...
  25. Shang X, Shen C, Liu J, Tang L, Zhang H, Wang Y, et al. Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding. Cell Mol Life Sci. 2018;75:4371-4384 pubmed publisher
    ..So far, the physiological function of PRSS55 remains unknown. Here, we show that PRSS55 is a GPI-anchored membrane protein, specifically expressed in adult mouse testis and mainly observed in the luminal side of ..
  26. Blanco M, Rodriguez Martin I, Learte A, Clemente C, Montalvo M, Seiki M, et al. Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo. PLoS ONE. 2017;12:e0184767 pubmed publisher
    ..Mmp17) that belongs to a distinct subset that is anchored to the cell surface via a glycosylphosphatidylinositol (GPI) moiety and with the catalytic site exposed to the extracellular space...
  27. Kim H, Thak E, Lee D, Agaphonov M, Kang H. Hansenula polymorpha Pmt4p Plays Critical Roles in O-Mannosylation of Surface Membrane Proteins and Participates in Heteromeric Complex Formation. PLoS ONE. 2015;10:e0129914 pubmed publisher
    ..HpWsc1p and HpMid2p, with marginal effects on secreted glycoproteins such as chitinase and HpYps1p lacking a GPI anchor...
  28. Kolicheski A, Johnson G, Mhlanga Mutangadura T, Taylor J, Schnabel R, Kinoshita T, et al. A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia. Neurogenetics. 2017;18:39-47 pubmed publisher
    ..PIGN encodes an enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors a variety of proteins including CD59 to the cell surface...
  29. Truong A, Yip C, Paye A, Blacher S, Munaut C, Deroanne C, et al. Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells. FEBS J. 2016;283:704-22 pubmed publisher
    Membrane type 4 matrix metalloproteinase (MT4-MMP) [matrix metalloproteinase (MMP) 17] is a GPI-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells...
  30. Paladino S, Lebreton S, Lelek M, Riccio P, De Nicola S, Zimmer C, et al. GPI-anchored proteins are confined in subdiffraction clusters at the apical surface of polarized epithelial cells. Biochem J. 2017;474:4075-4090 pubmed publisher
    ..It was previously shown that, at the apical surface of polarized MDCK cells, glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are organized in small cholesterol-independent clusters of single GPI-AP species (..
  31. Rusz J, Tykalová T, Fecikova A, Šťastná D, Urgosik D, Jech R. Dualistic effect of pallidal deep brain stimulation on motor speech disorders in dystonia. Brain Stimul. 2018;11:896-903 pubmed publisher
    Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering...
  32. Heiss C, Wang Z, Black I, Azadi P, Fichorova R, Singh B. Novel structural features of the immunocompetent ceramide phospho-inositol glycan core from Trichomonas vaginalis. Carbohydr Res. 2016;419:51-9 pubmed publisher
    ..This appears to be the most striking and novel feature of this GPI-anchor type molecule.
  33. Wei W, Shi Q, Zhang N, Xiao K, Chen L, Yang X, et al. Expression of prion protein is closely associated with pathological and clinical progression and abnormalities of p53 in head and neck squamous cell carcinomas. Oncol Rep. 2016;35:817-24 pubmed publisher
    Prion protein (PrP) is a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein that functions as a unique pathogenic agent in transmissible spongiform encephalopathy (TSE)...
  34. Bostaille N, Gauquier A, Twyffels L, Vanhollebeke B. Molecular insights into Adgra2/Gpr124 and Reck intracellular trafficking. Biol Open. 2016;5:1874-1881 pubmed publisher
    ..Adgra2, formerly known as Gpr124, is a key regulator of cerebrovascular development in vertebrates. Together with the GPI-anchored glycoprotein Reck, this adhesion GPCR (aGPCR) stimulates Wnt7-dependent Wnt/?-catenin signaling to promote ..
  35. Trudu M, Schaeffer C, Riba M, Ikehata M, Brambilla P, Messa P, et al. Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations. Sci Rep. 2017;7:7383 pubmed publisher
    ..Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of the thick ascending limb of Henle's loop...
  36. Zhang L, Zhang Q, Wang X, Yang X, Li X, Yuan M. Selection of reference genes for qRT-PCR and expression analysis of high-altitude-related genes in grassland caterpillars (Lepidoptera: Erebidae: Gynaephora) along an altitude gradient. Ecol Evol. 2017;7:9054-9065 pubmed publisher
    ..Additionally, the expression patterns of four other genes (GPI,HIF1A,HSP20, and USP) associated with adaptation to extreme environments were assessed to ..
  37. Suzuki K. Single-Molecule Imaging of Signal Transduction via GPI-Anchored Receptors. Methods Mol Biol. 2016;1376:229-38 pubmed publisher
    ..In this chapter, we describe how to examine dynamics of raft-associated glycosylphosphatidylinositol (GPI)-anchored receptors and interactions of the receptors with downstream signaling molecules by single-particle ..
  38. Kurosaki A, Hasegawa K, Kato T, Abe K, Hanaoka T, Miyara A, et al. Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression. Int J Cancer. 2016;138:1994-2002 pubmed publisher
    Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene...
  39. Niu E, Shang X, Cheng C, Bao J, Zeng Y, Cai C, et al. Comprehensive Analysis of the COBRA-Like (COBL) Gene Family in Gossypium Identifies Two COBLs Potentially Associated with Fiber Quality. PLoS ONE. 2015;10:e0145725 pubmed publisher
    COBRA-Like (COBL) genes, which encode a plant-specific glycosylphosphatidylinositol (GPI) anchored protein, have been proven to be key regulators in the orientation of cell expansion and cellulose crystallinity status...
  40. Kronbichler A, Saleem M, Meijers B, Shin J. Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View. J Immunol Res. 2016;2016:2068691 pubmed publisher
    ..plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes...
  41. Johnson K, Cassin A, Lonsdale A, Wong G, Soltis D, Miles N, et al. Insights into the Evolution of Hydroxyproline-Rich Glycoproteins from 1000 Plant Transcriptomes. Plant Physiol. 2017;174:904-921 pubmed publisher
    ..Significantly, data mining reveals the origin of glycosylphosphatidylinositol (GPI)-anchored AGPs in green algae and a 3- to 4-fold increase in GPI-AGPs in liverworts and mosses...
  42. Zhu D, Qin Y, Wang J, Zhang L, Zou S, Zhu X, et al. Novel Glypican-3-Binding Peptide for in Vivo Hepatocellular Carcinoma Fluorescent Imaging. Bioconjug Chem. 2016;27:831-9 pubmed publisher
    ..is a key member of the glypican family that is expressed on the cell surface by a glycosyl-phosphatidyl-inositol (GPI) anchor. It plays a significant role in hepatocellular carcinoma (HCC) development, angiogenesis, and metastasis...
  43. Kaur H, Gupta A. Morphological, histopathological and molecular characterization of <i>Thelohanellus pathankotensis</i> n. sp. (Cnidaria: Myxosporea: Myxozoa) infecting an Indian minor carp, <i>Labeo</i> <i>dero</i> Hamilton, 1822 . Zootaxa. 2017;4353:161-173 pubmed publisher
    ..The intensity of infection or the mean abundance was determined by the gill plasmodial index (GPI) based on the number of countable plasmodia...
  44. Nakano N, Miyauchi M, Nakanishi K, Saigoh K, Mitsui Y, Kato A. Successful Combination of Pallidal and Thalamic Stimulation for Intractable Involuntary Movements in Patients with Neuroacanthocytosis. World Neurosurg. 2015;84:1177.e1-7 pubmed publisher
    ..b>Gpi stimulation alone was an insufficient effect for trunk spasm and/or chorea...
  45. Umeda N, Matsumoto I, Kawaguchi H, Kurashima Y, Kondo Y, Tsuboi H, et al. Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases. Clin Rheumatol. 2016;35:1181-8 pubmed publisher
    ..Antibodies against cyclic citrullinated glucose-6-phosphate isomerase (GPI) (CCG)-2, CCG-7, anti-CEP-1, and anti-CCP Abs were also measured using ELISA...
  46. Schmidt C, Harder M, Nichols E, Hebecker M, Anliker M, Höchsmann B, et al. Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients. Immunobiology. 2016;221:503-11 pubmed publisher
    Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators...
  47. Belasen A, Youn Y, Gee L, Prusik J, Lai B, Ramírez Zamora A, et al. The Effects of Mechanical and Thermal Stimuli on Local Field Potentials and Single Unit Activity in Parkinson's Disease Patients. Neuromodulation. 2016;19:698-707 pubmed publisher
    ..We assessed changes in LFPs and SUAs in the subthalamic nucleus (STN), globus pallidus interna (Gpi), and globus pallidus externa (Gpe) following exposure with mechanical or thermal stimuli...
  48. Andreou C, Maniotis C, Koutouzis M. The Rise and Fall of Anticoagulation with Bivalirudin During Percutaneous Coronary Interventions: A Review Article. Cardiol Ther. 2017;6:1-12 pubmed publisher
    ..Treatment with bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPI) reduced bleeding complications, but resulted in higher rates of ischemic events, including acute stent thrombosis ..
  49. Li C, Yeh F, Cheung A, Duan Q, Kita D, Liu M, et al. Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis. elife. 2015;4: pubmed publisher
    ..Here we report that the female gametophyte-expressed glycosylphosphatidylinositol-anchored protein (GPI-AP) LORELEI and the seedling-expressed LRE-like GPI-AP1 (LLG1) bind to the extracellular juxtamembrane region of ..
  50. Wang H, Yu J, Li L. A DNA vaccine encoding mutated HPV58 mE6E7-Fc-GPI fusion antigen and GM-CSF and B7.1. Onco Targets Ther. 2015;8:3067-77 pubmed publisher
    ..their oncogenic potential and constructed a recombinant DNA vaccine that coexpresses the sig-HPV58 mE6E7-Fc-GPI fusion antigen in addition to granulocyte-macrophage colony-stimulating factor (GM-CSF) and B7...
  51. Kumar A, Bhanja A, Bhattacharyya J, Jaganathan B. Multiple roles of CD90 in cancer. Tumour Biol. 2016;37:11611-11622 pubmed
    THY1 (CD90) is a 25-37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein...
  52. Al Abadi A, Shahid S. A comparison between index of entropy and catastrophe theory methods for mapping groundwater potential in an arid region. Environ Monit Assess. 2015;187:576 pubmed publisher
    ..The groundwater potential index (GPI) values for both models were classified using natural break classification scheme into five categories: very low, ..
  53. Park K, Kim J, Choi C, Bae J, Kim S, Kim Y, et al. Molecular Cloning and Expression Analysis of Pig Cd90. Anim Biotechnol. 2016;27:133-9 pubmed publisher
    The CD90 (Thy-1) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that transfers signals involved in many biological events including cell activation, cell migration, cell adhesion, and tumor suppression...
  54. Dar S, Kaur H, Chishti M. Myxobolus chushi n. sp. (Myxozoa:Myxosporea) parasitizing Schizothorax niger (Heckel), a native cyprinid fish from Wullar Lake in Kashmir Himalayas. Parasitol Int. 2017;66:272-278 pubmed publisher
    ..The intensity of infection was recorded to be moderate as indicated by gill plasmodial index (GPI=2)...
  55. Weidanz J, Campbell P, DeLucas L, Jin J, Moore D, Roden L, et al. Glucosamine 6-phosphate deaminase in normal human erythrocytes. Br J Haematol. 1995;91:72-9 pubmed
    ..In addition, the deaminase was also inhibited by several sugar phosphates including the reaction product, fructose 6-phosphate. ..
  56. Li J, Yang Y, Huan H, Li M, Xi B, Lv N, et al. Method for screening prevention and control measures and technologies based on groundwater pollution intensity assessment. Sci Total Environ. 2016;551-552:143-54 pubmed publisher
    ..This paper presents a system for determining the evaluation and gradation indices of groundwater pollution intensity (GPI)...
  57. Bate C, Nolan W, McHale Owen H, Williams A. Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses. J Biol Chem. 2016;291:17093-101 pubmed publisher
    ..both neuronal cholesterol concentrations and the lipid and glycan composition of its glycosylphosphatidylinositol (GPI) anchor...
  58. Ray A, Jatana N, Thukral L. Lipidated proteins: Spotlight on protein-membrane binding interfaces. Prog Biophys Mol Biol. 2017;128:74-84 pubmed publisher
    ..palmitoylation, myristoylation, prenylation, cholesterylation, and addition of the Glycosylphosphatidyl inositol (GPI) anchor...
  59. Münte T, Marco Pallares J, Bolat S, Heldmann M, Lütjens G, Nager W, et al. The human globus pallidus internus is sensitive to rewards - Evidence from intracerebral recordings. Brain Stimul. 2017;10:657-663 pubmed publisher
    The globus pallidus internus (GPi) is the final output relay of the basal ganglia for the control of movements but has also been shown to belong to a second pathway projecting to the lateral habenula...
  60. Rouhollahi K, Emadi Andani M, Karbassi S, Izadi I. Design of robust adaptive controller and feedback error learning for rehabilitation in Parkinson's disease: a simulation study. IET Syst Biol. 2017;11:19-29 pubmed publisher
    ..The other area (GPi: globus pallidus internal) is stimulated by a partial state feedback (PSF) controller...
  61. Sidiropoulos C, Rammo R, Merker B, Mahajan A, LeWitt P, Kaminski P, et al. Intraoperative MRI for deep brain stimulation lead placement in Parkinson's disease: 1 year motor and neuropsychological outcomes. J Neurol. 2016;263:1226-31 pubmed publisher
    ..Mean radial error for the STN group was 1.2 ± 0.7 mm and for the GPi group 0.8 mm ± 0.3 mm...
  62. Kariithi H, Boeren S, Murungi E, Vlak J, Abd Alla A. A proteomics approach reveals molecular manipulators of distinct cellular processes in the salivary glands of Glossina m. morsitans in response to Trypanosoma b. brucei infections. Parasit Vectors. 2016;9:424 pubmed publisher
    ..Moreover, we identified 158 trypanosome-specific proteins, notable of which were proteins in the families of the GPI-anchored surface glycoproteins, kinetoplastid calpains, peroxiredoxins, retrotransposon host spot multigene and ..
  63. Prescott I, MARINO R, Levy R. Field evoked potentials in the globus pallidus of non-human primates. Neurosci Res. 2017;120:18-27 pubmed publisher
    ..The aim of this study was to ascertain whether fEPs were inducible in the external (GPe) and internal (GPi) segments of the globus pallidus in normal non-human primates (NHPs)...
  64. David R, Talbot E, Allen B, Wilson A, Arshad U, Doherty A. The development of an in vitro Pig-a assay in L5178Y cells. Arch Toxicol. 2018;92:1609-1623 pubmed publisher
    ..Pig-a forms the catalytic subunit of N-acetylglucosaminyltransferase required for glycophosphatidylinositol (GPI) anchor biosynthesis...
  65. Greene W, Macnish M, Rice K, Thompson R. Identification of genes associated with blood feeding in the cat flea, Ctenocephalides felis. Parasit Vectors. 2015;8:368 pubmed publisher
    ..proteases, a serine protease inhibitor, two mucin-like molecules, a DNA topoisomerase, an enzyme associated with GPI-mediated cell membrane attachment of proteins and a component of the insect innate immune response...
  66. Slotty P, Poologaindran A, Honey C. A prospective, randomized, blinded assessment of multitarget thalamic and pallidal deep brain stimulation in a case of hemidystonia. Clin Neurol Neurosurg. 2015;138:16-9 pubmed publisher
    ..DBS leads were implanted in the GPi and Vim/Vop and each stimulation combination (GPi, Vim/Vop, and both) was tested for three months in a single ..
  67. Antoniades C, Rebelo P, Kennard C, Aziz T, Green A, Fitzgerald J. Pallidal Deep Brain Stimulation Improves Higher Control of the Oculomotor System in Parkinson's Disease. J Neurosci. 2015;35:13043-52 pubmed publisher
    ..nucleus (STN) has no effect on the AER, but a previous case suggested that DBS of the globus pallidus interna (GPi) might. Our aim was to compare the effects of STN DBS and GPi DBS on the AER...
  68. Boel J, Odekerken V, Schmand B, Geurtsen G, Cath D, Figee M, et al. Cognitive and psychiatric outcome 3 years after globus pallidus pars interna or subthalamic nucleus deep brain stimulation for Parkinson's disease. Parkinsonism Relat Disord. 2016;33:90-95 pubmed publisher
    ..cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD)...
  69. Rodrigues M, Borges N, Santos H. Glycerol Phosphate Cytidylyltransferase Stereospecificity Is Key to Understanding the Distinct Stereochemical Compositions of Glycerophosphoinositol in Bacteria and Archaea. Appl Environ Microbiol. 2017;83: pubmed publisher
    Glycerophosphoinositol (GPI) is a compatible solute present in a few hyperthermophiles...
  70. Carulli G, Marini A, Sammuri P, Domenichini C, Ottaviano V, Pacini S, et al. Combination of CD157 and FLAER to Detect Peripheral Blood Eosinophils by Multiparameter Flow Cytometry. J Clin Exp Hematop. 2015;55:55-60 pubmed publisher
    ..In the present study we report a novel method based on the analysis of glycosylphosphatidylinositol (GPI)-linked molecules...
  71. Shah R, Rogers K, Matin K, Askari R, Rao S. An updated comprehensive meta-analysis of bivalirudin vs heparin use in primary percutaneous coronary intervention. Am Heart J. 2016;171:14-24 pubmed publisher
    ..compare bivalirudin and heparin with or without provisional administration of a glycoprotein IIb/IIIa inhibitor (GPI) for primary PCI. Scientific databases and Web sites were searched for randomized clinical trials...
  72. Liu S, Wang L, Zheng H, Xu Z, Roellig D, Li N, et al. Comparative genomics reveals Cyclospora cayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens. BMC Genomics. 2016;17:316 pubmed publisher
    ..cayetanensis are very similar to those of Eimeria tenella. Propanoyl-CoA degradation, GPI anchor biosynthesis, and N-glycosylation are some apparent metabolic differences between C. cayetanensis and E...
  73. Kammermeier S, Pittard D, Hamada I, Wichmann T. Effects of high-frequency stimulation of the internal pallidal segment on neuronal activity in the thalamus in parkinsonian monkeys. J Neurophysiol. 2016;116:2869-2881 pubmed publisher
    Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease...
  74. Tsiokos C, Malekmohammadi M, AuYong N, Pouratian N. Pallidal low β-low γ phase-amplitude coupling inversely correlates with Parkinson disease symptoms. Clin Neurophysiol. 2017;128:2165-2178 pubmed publisher
    ..Within GPi, we identified PAC between phase of β and amplitude of high frequency oscillations (200-300Hz) and distinct β-low ..
  75. Mehdorn H. Deep brain stimulation for dystonia: review of the literature. J Neurosurg Sci. 2016;60:199-210 pubmed
    ..primary dystonia will benefit the most from DBS to the ventromediolateral part of the globus pallidus internus (GPi) with acceptable low complication rates; in order to optimize longterm results in these groups of patient, they ..
  76. Hong M, Ryu L, Ow M, Kim J, Je A, Chinta S, et al. Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans. Curr Biol. 2017;27:3168-3177.e3 pubmed publisher
    ..post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons...
  77. Fischer D, Collier T, Cole Strauss A, Wohlgenant S, Lipton J, Steece Collier K, et al. High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. PLoS ONE. 2015;10:e0133957 pubmed publisher
    ..Whereas the globus pallidus interna (GPi) has been less commonly targeted than the subthalamic nucleus (STN), a recent clinical trial suggests that GPi DBS ..
  78. Imboumy Limoukou R, Maghendi Nzondo S, Kouna C, Bounaadja L, Mbang S, Biteghe J, et al. Immunoglobulin response to the low polymorphic Pf113 antigen in children from Lastoursville, South-East of Gabon. Acta Trop. 2016;163:149-56 pubmed publisher
    Pf113 is a P. falciparum putatively GPI-anchored protein that has been so far localized at the surface of merozoites, suggesting it could interact with RBC surface during merozoite invasion...
  79. Gillies M, Hyam J, Weiss A, Antoniades C, Bogacz R, Fitzgerald J, et al. The Cognitive Role of the Globus Pallidus interna; Insights from Disease States. Exp Brain Res. 2017;235:1455-1465 pubmed publisher
    ..of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi)...
  80. Degryse B, Britto M, Shan C, Wallace R, Rochfort K, Cummins P, et al. Moesin and merlin regulate urokinase receptor-dependent endothelial cell migration, adhesion and angiogenesis. Int J Biochem Cell Biol. 2017;88:14-22 pubmed publisher
    The glycosyl-phosphatidyl-inositol (GPI)-anchored urokinase receptor (uPAR) has no intracellular domain, but nevertheless initiates signalling through proximal interactions with other membrane receptors including integrins...
  81. Buzza M, Johnson T, Conway G, Martin E, Mukhopadhyay S, Shea Donohue T, et al. Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. J Biol Chem. 2017;292:10801-10812 pubmed publisher
    ..Matriptase barrier-protective activity is linked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-factor for matriptase zymogen activation...
  82. Gottier P, González Salgado A, Menon A, Liu Y, Acosta Serrano A, Bütikofer P. RFT1 Protein Affects Glycosylphosphatidylinositol (GPI) Anchor Glycosylation. J Biol Chem. 2017;292:1103-1111 pubmed publisher
    ..brucei RFT1 (TbRFT1) not only affects protein N-glycosylation but also glycosylphosphatidylinositol (GPI) anchor side-chain modification...
  83. Ifeonu O, Simon R, Tennant S, Sheoran A, Daly M, Felix V, et al. Cryptosporidium hominis gene catalog: a resource for the selection of novel Cryptosporidium vaccine candidates. Database (Oxford). 2016;2016: pubmed publisher
    ..genes containing properties typical of surface-exposed antigens, such as predicted glycosylphosphatidylinositol (GPI)-anchor motifs, multiple transmembrane motifs and/or signal peptides targeting the encoded protein to the secretory ..
  84. Pagnamenta A, Murakami Y, Taylor J, Anzilotti C, Howard M, Miller V, et al. Analysis of exome data for 4293 trios suggests GPI-anchor biogenesis defects are a rare cause of developmental disorders. Eur J Hum Genet. 2017;25:669-679 pubmed publisher
    Over 150 different proteins attach to the plasma membrane using glycosylphosphatidylinositol (GPI) anchors...
  85. Vaddepalli P, Fulton L, Wieland J, Wassmer K, Schaeffer M, Ranf S, et al. The cell wall-localized atypical ?-1,3 glucanase ZERZAUST controls tissue morphogenesis in Arabidopsis thaliana. Development. 2017;144:2259-2269 pubmed publisher
    ..identification and functional characterization of ZERZAUST We show that ZERZAUST encodes a putative GPI-anchored ?-1,3 glucanase suggested to degrade the cell wall polymer callose...
  86. Beck A, Lütjens G, Schwabe K, Dengler R, Krauss J, Sandmann P. Thalamic and basal ganglia regions are involved in attentional processing of behaviorally significant events: evidence from simultaneous depth and scalp EEG. Brain Struct Funct. 2018;223:461-474 pubmed publisher
    ..in the subthalamic nucleus (STN), the ventrolateral posterior thalamus (VLp) or the globus pallidus internus (GPi)...
  87. Miranda B, Fotoran W, Canduri F, Souza D, Wunderlich G, Carrilho E. Heterologous expression of Homo sapiens alpha-folate receptors in E. coli by fusion with a trigger factor for enhanced solubilization. Protein Expr Purif. 2018;142:75-80 pubmed publisher
    ..The activity of rTFFR? was comparable to glycosylphosphatidylinositol (GPI) anchored proteins extracted from HeLa tumor cells...
  88. Moon H, Won S, Kim E, Kim H, Cho C, Park Y. Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-?-synuclein-induced hemiparkinson rat model. Neurosci Lett. 2018;662:129-135 pubmed publisher
    Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson's disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP)...
  89. Stöckmann H, Todorovic V, Richardson P, Marin V, Scott V, Gerstein C, et al. Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors. J Am Chem Soc. 2017;139:16822-16829 pubmed publisher
    ..We describe GlycoFRET for a GPI-anchored receptor, a G-protein-coupled receptor, and a heterodimeric cytokine receptor in living cells with ..
  90. Franzini A, Levi V, Franzini A, Dones I, Messina G. Staged pallidotomy: MRI and clinical follow-up in status dystonicus. Br J Neurosurg. 2017;:1-4 pubmed publisher
    We report on a patient affected by Status Distonicus who was treated with Deep Brain Stimulation electrodes implanted in the Globus Pallidus internus (Gpi) and used for serial radiofrequency lesions.
  91. van Veen M, Mans L, Matas Rico E, van Pelt J, Perrakis A, Moolenaar W, et al. Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish. Int J Biochem Cell Biol. 2018;94:71-78 pubmed publisher
    ..One regulator of the Notch pathway is GDE2 (or GDPD5), a transmembrane ecto-phosphodiesterase that cleaves GPI-anchored proteins at the plasma membrane, including a Notch ligand regulator...
  92. Nakamura Y, Miura K, Fujino Y, Iwao H, Ogita S, Yamanaka S. Evolution, structure, and expression of GNPI/Oscillin orthologous genes. Genomics. 2000;68:179-86 pubmed
    b>Oscillin was identified from hamster sperm as a factor responsible for oocyte calcium oscillations. However, its high level of homology with the bacterial glucosamine-6-phosphate isomerase suggests that it may play more fundamental roles...