Gene Symbol: GNGT2
Description: G protein subunit gamma transducin 2
Alias: G-GAMMA-8, G-GAMMA-C, GNG8, GNG9, GNGT8, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2, G protein cone gamma 8 subunit, G-gamma-9, g gamma-C, gamma-T2 subunit, guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2, guanine nucleotide binding protein gamma 9, guanine nucleotide binding protein gamma transducing activity polypeptide 2
Cook L, Schey K, Cleator J, Wilcox M, Dingus J, Hildebrandt J. Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. Protein Sci. 2001;10:2548-55 pubmed
..These data suggest that the N-terminus of gamma is a functionally important part of the protein exhibiting substantial isoform-specific variation. ..
Cuello F, Schulze R, Heemeyer F, Meyer H, Lutz S, Jakobs K, et al
. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003;278:7220-6 pubmed
..We conclude that NDPK B forms complexes with Gbetagamma dimers and contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP via intermediately phosphorylated His-266 in Gbeta(1) subunits. ..
Fowler C, Aryal P, Suen K, Slesinger P. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol. 2007;580:51-65 pubmed
..2a and RGS4 nor between Kir3.2a and Galphao. These data are discussed in terms of a model in which GABA(B) receptors, G proteins, RGS4 proteins and Kir3 channels are closely associated in a signalling complex. ..
Yan K, Kalyanaraman V, Gautam N. Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. J Biol Chem. 1996;271:7141-6 pubmed
..The strong preference of all gamma subunit types for the beta1 subunit type explains the preponderence of this subunit type in most G proteins. ..
Huang C, Jan Y, Jan L. Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett. 1997;405:291-8 pubmed
..These results are consistent with the idea that the N- and C-terminal domains of the cardiac G protein-gated K+ channel subunits may interact with each other to form higher affinity binding site(s) for G betagamma. ..
Ong O, Hu K, Rong H, Lee R, Fung B. Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2). Genomics. 1997;44:101-9 pubmed
..We have previously identified in bovine retinas a cone-specific G-protein gamma subunit (G gamma c, previously named G gamma b), which may play a key role in coupling the cone visual pigment to phosphodiesterase ..
Huang L, Shanker Y, Dubauskaite J, Zheng J, Yan W, Rosenzweig S, et al
. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999;2:1055-62 pubmed
..We conclude that gustducin heterotrimers transduce responses to bitter and sweet compounds via alpha-gustducin's regulation of phosphodiesterase (PDE) and Gbetagamma's activation of phospholipase C (PLC). ..
Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser Steinecke B, Schreibmayer W, et al
. Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. J Biol Chem. 2003;278:29174-83 pubmed
Yang M, He R, Benovic J, Ye R. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Biochem J. 2009;417:287-96 pubmed publisher
..These results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation. ..