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| GNAI3SummaryGene Symbol: GNAI3 Description: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Alias: 87U6, ARCND1, g(i) alpha-3, guanine nucleotide-binding protein G(k) subunit alpha Species: human Top Publications
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Publications
Distinct guanine nucleotide binding and release properties of the three Gi proteinsD J Carty
Department of Pharmacology, Mount Sinai School of Medicine, City University, New York, New York 10029
J Biol Chem 265:6268-73. 1990....- RGS10 is a selective activator of G alpha i GTPase activityT W Hunt
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 383:175-7. 1996..These results demonstrate that RGS proteins can attenuate signalling pathways involving heterotrimeric G proteins by serving as GTPase-activating proteins for specific types of G alpha subunits... - Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIPD S Woulfe
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 274:17718-24. 1999..Thus, GAIP was able to discriminate between Galphai1 and Galphai2 in both binding and functional assays, and in both cases residue 229/230 played a critical role in selective recognition... - Changes in expression of adenyl cyclase activity in human endometrium during hormone replacement therapy and ovarian stimulationL Bernardini
Department of Obstetrics and Gynaecology, University of Genoa, Genoa, Italy
Mol Hum Reprod 5:955-60. 1999..These data strongly support the concept that the transmembrane signalling AC system and its messenger cyclic AMP are major regulators of endometrial function in the human... 
Variations in Gnai2 and Rgs1 expression affect chemokine receptor signaling and the organization of secondary lymphoid organsI Y Hwang
B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Genes Immun 11:384-96. 2010..Examination of B cells from mice with varying numbers of intact alleles of Ccr7, Rgs1, Gnai2, and Gnai3 provided the basis for these results...- Galpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteinsT S Weiss
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 98:14961-6. 2001..Calnuc has the properties of a Ca(2+) sensor protein capable of binding to and potentially regulating interactions of Galphai3 on Golgi membranes... - GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domainL de Vries
Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093 0651, USA
Proc Natl Acad Sci U S A 92:11916-20. 1995..The fact that GAIP and Sst2 interact with G alpha subunits and share a common domain suggests that other members of the GAIP family also interact with G alpha subunits through the 125-amino-acid core domain... - GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunitsL de Vries
Division of Cellular and Molecular Medicine, University of California at San Diego, La Jolla 92093 0651, USA
Proc Natl Acad Sci U S A 93:15203-8. 1996..This motif, present in cysteine string proteins found on synaptic vesicles, pancreatic zymogen granules, and chromaffin granules, suggests GAIP's possible involvement in membrane trafficking... - Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13I Magovcevic
Department of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Genomics 12:125-9. 1992..family, include a small number of polypeptides: Gi alpha 1 (GNAI1), Gi alpha 2 (GNAI2), and Gi alpha 3 (GNAI3)... - Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)A Caricasole
Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
Biochim Biophys Acta 1517:63-72. 2000..Finally, we characterized the structure of the PLC beta 1 locus and confirmed its mapping to human chromosome 20... - Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIPThierry Fischer
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 100:8270-5. 2003..RGS-GAIP functions as a bifunctional adaptor that binds to G alpha subunits through its RGS domain and to GIPN through its cysteine string motif... - Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factorGregory G Tall
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75390 9041, USA
J Biol Chem 278:8356-62. 2003..Ric-8A interacts with GDP-bound Galpha proteins, stimulates release of GDP, and forms a stable nucleotide-free transition state complex with the Galpha protein; this complex dissociates upon binding of GTP to Galpha... - Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signalingYuren Wang
Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey 08543 8000, USA
J Biol Chem 277:48325-32. 2002..In summary, these data suggest that RGSZ1 serves as a GTPase accelerating protein for Galpha(i) and regulates Galpha(i)-mediated signaling, thus expanding the potential role of RGSZ1 in G protein-mediated cellular activities... - P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouseFang L Zhang
Human Genome Research, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
J Pharmacol Exp Ther 301:705-13. 2002..In keeping with the general nomenclature for the purinergic receptors, we propose designating this novel receptor P2Y(13)... - Cloning and characterization of a novel regulator of G protein signalling in human plateletsAlison W Gagnon
Cardiovascular Drug Discovery, Aventis Pharmaceuticals, 500 Arcola Road, Collegeville, PA 19426, USA
Cell Signal 14:595-606. 2002..RGS18 is expressed in platelet, leukocyte, and megakaryocyte cell lines and binds to endogenous Galphai1, Galphai2, Galphai3, and Galphaq but not Galphaz, Galphas or Galpha12 in vitro... - The G protein subunit gene familiesG B Downes
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Genomics 62:544-52. 1999 - Coupling of dopamine receptor subtypes to multiple and diverse G proteinsA Sidhu
Laboratory of Molecular Neurochemistry, Department of Pediatrics, Georgetown University Medical Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USA
Int J Dev Neurosci 18:669-77. 2000.... - Functional reconstitution of the angiotensin II type 2 receptor and G(i) activationJ L Hansen
Laboratory for Molecular Cardiology and the Department of Medicine B, University of Copenhagen, Denmark
Circ Res 87:753-9. 2000..In combination with previous observations, these results show that the AT(2) receptor is fully capable of activating G(i) and provides a new tool for exploring AT(2) receptor pharmacology and interactions with G-protein trimers... - RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor ActivityR J Kimple
Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
J Biol Chem 276:29275-81. 2001..The presence of two, independent G alpha interaction sites suggests that RGS12 and RGS14 participate in a complex coordination of G-protein signaling beyond simple G alpha GAP activity... - Characterization of RGS5 in regulation of G protein-coupled receptor signalingJ Zhou
Department of Biochemistry and Molecular Pharmacology, Chiba University Graduate School of Medicine, Japan
Life Sci 68:1457-69. 2001.... - Identification of the platelet ADP receptor targeted by antithrombotic drugsG Hollopeter
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
Nature 409:202-7. 2001..Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases... - CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domainsS Mukhopadhyay
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, MO, USA
Eur J Biochem 268:499-505. 2001..These studies indicate that different domains of the CB(1) receptor direct the interaction with specific G protein subtypes... - RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytesD Yowe
Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA
Biochem J 359:109-18. 2001..Hence RGS18 might have an important role in the regulation of megakaryocyte differentiation and chemotaxis... - Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitorKeisuke Wakasugi
Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Japan
J Biol Chem 278:36505-12. 2003..In contrast, ferrous ligand-bound Ngb under normoxia did not have GDI activities. Taken together, we propose that human Ngb may be a novel oxidative stress-responsive sensor for signal transduction in the brain... - Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progressionRachna Kaushik
Institute of Molecular and Cell Biology, Singapore 117609
Mol Biol Cell 14:3144-55. 2003..The results also show that the cortical localization of LGN is dependent on microfilaments and that interfering with LGN function in cultured cell lines causes early disruption to cell cycle progression... - Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunitsShai Berlin
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
J Biol Chem 286:33223-35. 2011..Our findings support the notion that Gα(i/o) actively regulates GIRK. Although regulation of I(basal) is a function of Gα(i)(GDP), our new findings indicate that regulation of kinetics of I(evoked) is mediated by Gα(i)(GTP)... - A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signalsMikel Garcia-Marcos
Departments of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Mol Biol Cell 22:673-86. 2011..These results provide mechanistic insights into how reversible modulation of Gα(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy... 
TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformationBenoit Laliberte
Ottawa Hospital Research Institute Neuroscience, University of Ottawa, Ottawa, ON, Canada
J Cell Physiol 225:865-74. 2010..The data suggest that Gαi-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation...- Activation of mast cells by trimeric G protein Gi3; coupling to the A3 adenosine receptor directly and upon T cell contactDana Baram
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Immunol 184:3677-88. 2010..These results unveil the physiological G-protein coupled receptor that couples to Gi3 and establish the important role played by this G-protein in inflammatory conditions that involve adenosine-activated mast cells... - Genome-wide association study of recurrent early-onset major depressive disorderJ Shi
Department of Psychiatry, Stanford University, Stanford, CA, USA
Mol Psychiatry 16:193-201. 2011..Larger samples will be required to confirm the hypothesis of association between MDD (and particularly the recurrent early-onset subtype) and common SNPs... - Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteableAli Vural
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Mol Cell Biol 30:1528-40. 2010..These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies... - Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G{alpha}i3Robert S Flynn
Department of Medicine, Virginia Commonwealth University, Richmond, USA
Am J Physiol Gastrointest Liver Physiol 297:G1232-8. 2009..Our results indicate that endogenous IGFBP-5 activates Gi3 and regulates smooth muscle growth, IGF-I production, and collagen production via the alpha-subunit of Gi3, independently of IGF-I, in normal human intestinal muscle cells... - Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's diseaseYonghong Li
Celera, Alameda, California, United States of America
PLoS ONE 3:e2707. 2008..Together, these results challenge the robustness of the reported panel of genetic markers to predict PD risk in particular and a role of the axon guidance pathway in PD genetics in general... - Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-Kyung Hee Rhee
Life Sciences Division, Biomedical Research Center, Korea Institute of Science and Technology, Division of Biotechnology, Korea University, Seoul 136 701, South Korea
Protein Pept Lett 13:945-9. 2006..9 A, and c=138.8 A. Assuming one complex protein in the crystallographic asymmetric unit, the calculated Matthews parameter (V(M)) is 2.57 A(3)/Da and solvent content is 52.2 %... - Mechanism of the receptor-catalyzed activation of heterotrimeric G proteinsWilliam M Oldham
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
Nat Struct Mol Biol 13:772-7. 2006..These data provide the first direct observation of R*-mediated conformational changes in G proteins and define the structural basis for GDP release from G alpha... - Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3Hyung Ki Lee
Life Sciences Division, Korea Institute of Science and Technology, Seoul 130 650, South Korea
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:831-3. 2005..88, b = 99.88, c = 144.59 A, alpha = beta = gamma = 90 degrees . A full set of diffraction data were collected to 2.5 A resolution at 100 K using synchrotron radiation at Pohang beamline 4A... - G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2)Francis S Willard
Department of Pharmacology, CB 7365, 1106 Mary Ellen Jones Building, University of North Carolina, Chapel Hill, NC 27599 7365, USA
Cell Signal 18:1226-34. 2006..Collectively, the data demonstrate that PCP-2 is a comparatively weak GoLoco motif protein that exhibits highest affinity interactions and GDI activity toward Galphai1, Galphai2, and Galphai3 subunits... - Severe autosomal recessive retinitis pigmentosa maps to chromosome 1p13.3-p21.2 between D1S2896 and D1S457 but outside ABCA4Qingjiong Zhang
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Building 10, Room 10B10, 10 Center Drive, MSC 1860, Bethesda, MD, 20892 1860, USA
Hum Genet 118:356-65. 2005..Sequencing the exons and intron-exon boundaries of five candidate genes and six ESTs in this region, OLFM3, GNAI3, LOC126987, FLJ25070, DKFZp586G0123, AV729694, BU662869, BU656110, BU171991, BQ953690, and CA397743, did not .. - Analysis of RGSZ1 protein interaction with Galphai subunitsYuren Wang
Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey 08543, USA
Methods Enzymol 390:31-52. 2004.... - Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)P G Burgon
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Biol Chem 276:32828-34. 2001..Rather, the phosphorylation event correlates with translocation of RGS10 from the plasma membrane and cytosol into the nucleus... - Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteinsL Brydon
CNRS UPR 0415 and Université Paris VII, Institut Cochin de Genetique Moleculaire, Paris, France
Mol Endocrinol 13:2025-38. 1999..We show that Mel 1a receptors functionally couple to both PTX-sensitive and PTX-insensitive G proteins. The previously unknown signaling of Mel 1a receptors through G(q/11) widens the spectrum of potential targets for melatonin... - The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein familiesK L Laugwitz
Institut fur Pharmakologie, Freie Universitat Berlin, Germany
Proc Natl Acad Sci U S A 93:116-20. 1996.... - The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2M A Wall
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
Cell 83:1047-58. 1995..Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade... - Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancyG N Europe-Finner
University of Oxford, Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Headington, United Kingdom
Endocrinology 132:2484-90. 1993..The increase in G alpha s levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy... - G protein-coupled signal transduction pathways for interleukin-8D Wu
Division of Biology, California Institute of Technology, Pasadena 91125
Science 261:101-3. 1993..These findings suggest that IL-8 acts through signal-transducing pathways that are limited to specific heterotrimeric G proteins and effectors. These may provide suitable targets for the development of anti-inflammatory agents... - Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alphaJ R Raymond
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Biochemistry 32:11064-73. 1993..One factor influencing the relative importance of those G proteins for 5-HT1A receptor-inhibited adenylylcyclase activity appears to be their-relative levels of expression.(ABSTRACT TRUNCATED AT 250 WORDS).. - Structural determinants for activation of the alpha-subunit of a heterotrimeric G proteinD G Lambright
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510
Nature 369:621-8. 1994..The changes are distinct from those observed in other members of the GTPase superfamily... - Stabilization of C5a receptor--G-protein interactions through ligand bindingL P Wennogle
Research Department, Ciba Geigy Pharmaceuticals Division, Summit, New Jersey 07901
J Cell Biochem 55:380-8. 1994..The method of stabilization of receptor-transducer complexes offers the opportunity to further elaborate the interactions of the C5a receptor with diverse transducing elements and second messenger systems... - Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunitsJ C Migeon
Department of Pharmacology, University of Washington, Seattle 98195 7750, USA
J Biol Chem 270:16070-4. 1995..The m2 and m4 mAChRs thus couple to inhibition of adenylyl cyclase by overlapping but different sets of G-protein alpha subunits... - Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell linesS Y Kim
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
Proc Natl Acad Sci U S A 85:4153-7. 1988..Thus, some cells contain all three alpha i subtypes. This observation raises the question of how cells prevent cross talk among receptors that are coupled to effectors through such similar alpha proteins... - A small multigene family encodes Gi signal-transduction proteinsC R Beals
Howard Hughes Medical Institute, University of Washington, Seattle 98195
Proc Natl Acad Sci U S A 84:7886-90. 1987..Our data support the view that a modest repertoire of extremely closely related G proteins mediates the transduction of signals derived from multiple different receptor molecules... - Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein familiesJ R Didsbury
FEBS Lett 219:259-63. 1987..One group probably contains true Gi and the other a new class of G protein whose function remains to be determined... - Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and humanC Blatt
Weizmann Institute, Rehovoth, Israel
Proc Natl Acad Sci U S A 85:7642-6. 1988..The retinal-specific transducin subunit genes GNAT1 and GNAT2 were on chromosomes 3 and 1; GNAI1, GNAI2, and GNAI3 were assigned to chromosomes 7, 3, and 1, respectively; GNAZ and GNAS were found on chromosomes 22 and 20... - Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channelsJ Codina
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 263:6746-50. 1988..The probable identity of alpha i-1 with alpha p and possible roles for alpha i-2, as well as additional roles for alpha i-1 and alpha i-3 (alpha k) are discussed... - The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathwayM J Lee
Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
J Biol Chem 271:11272-9. 1996..These data suggest that the G(i)/mitogen-activated protein kinase pathway is a major signaling pathway regulated by the orphan receptor edg-1... - The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytesK R Solomon
Laboratory of Infectious Diseases, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 93:6053-8. 1996..These experiments suggest a potential role of G proteins in the transduction of signals generated by GPI-anchored molecules expressed on lymphocytes of both mouse and human... - The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetusJ Zhang
Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, California 94305 5246, USA
J Biol Chem 271:15026-33. 1996..The finding that AT2 receptor couples to both Gialpha2 and Gialpha3 raises the possibility that selective interactions between AT2 receptor and different G proteins may result in specific cellular effects mediated by AT2 stimulation... - Initiation of DNA replication at the Chinese hamster origin oriGNAI3 relies on local sequences and/or chromatin structures, but not on transcription of the nearby GNAI3 geneF Toledo
Unité de Génétique Somatique URA CNRS 1960, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nucleic Acids Res 27:1600-8. 1999..identified a region of preferential replication initiation, oriGNAI3, near the 3' end of the Chinese hamster GNAI3 gene... - Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytesC Beadling
Immunology Program, Cornell University Graduate School of Medical Sciences, Division of Immunology, Cornell University Medical College, New York, NY 10021, USA
J Immunol 162:2677-82. 1999.... - Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cellsM Jiang
Department of Microbiology, University of Southern California School of Medicine, Los Angeles 90033
Proc Natl Acad Sci U S A 88:3907-11. 1991..The results indicate that this G alpha subunit belongs to a separate subfamily of G proteins that may be insensitive to inhibition by pertussis toxin... - RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11N O Dulin
Department of Medicine and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Mol Cell Biol 19:714-23. 1999..These data indicate that RGS3 inhibits G protein-coupled receptor signaling by a complex mechanism involving its translocation to the membrane in addition to its established function as a GTPase-activating protein... - A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acidN Fukushima
Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0636, USA
Proc Natl Acad Sci U S A 95:6151-6. 1998..These results demonstrate that a single receptor, encoded by vzg-1, can activate multiple LPA-dependent responses in cells from distinct tissue lineages... - oriGNAI3: a narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniquesF Toledo
Unité de Génétique Somatique URA CNRS 1960, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nucleic Acids Res 26:2313-21. 1998..In this report we analyze the replication of an amplified genomic region encompassing the 3'-end of the GNAI3 gene, the entire GNAT2 gene and the intergenic region between them in exponentially growing Chinese hamster .. - Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeastC Chen
Regulatory Biology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Republic of Singapore
J Biol Chem 272:8679-85. 1997.... - The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident proteinP Lin
Division of Cellular and Molecular Medicine and Department of Pathology, University of California, San Diego, La Jolla, California 92093 0651, USA
J Cell Biol 141:1515-27. 1998..The properties of CALNUC and its high homology to calreticulin suggest that it may play a key role in calcium homeostasis in the CGN and cis-Golgi cisternae... - Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAsH Itoh
Institute of Medical Science, University of Tokyo, Japan
J Biol Chem 263:6656-64. 1988..Southern blot analysis indicates that a single copy of each Gi alpha gene is present per haploid human genome... - Dissociation of heterotrimeric g proteins in cellsNevin A Lambert
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
Sci Signal 1:re5. 2008..This unexpectedly reluctant dissociation calls for inclusion of a GTP-bound heterotrimeric state in models of the G protein cycle and places renewed emphasis on the relation between subunit dissociation and effector activation... - CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteinsAnja Mueller
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK
FEBS Lett 570:126-32. 2004..Gi protein activation was not prevented by inhibition of JAK, showing that heterotrimeric G protein activation and activation of the JAK/signal transducer and activator of transcription (STAT) pathway are independent of each other... - Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cellsJ L Adolfsson
Division of Experimental Pathology, Lund University, Wallenberg Laboratory, Malmo, Sweden
Biochem Biophys Res Commun 226:413-9. 1996..Furthermore, the translocation of G alpha i3-subunits to the cytoskeleton and the simultaneous inhibition of G3-proteins indicate that the cytoskeleton might participate in the signalling process of human epithelial cells... - Activation of Galphai3 triggers cell migration via regulation of GIVPradipta Ghosh
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Cell Biol 182:381-93. 2008.... - Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1S Miotti
Unit of Molecular Therapies, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
J Cell Sci 113:349-57. 2000..These findings point to the functional interaction between folate receptor and associated signaling molecules... - The human genome encodes at least three non-allellic G proteins with alpha i-type subunitsW N Suki
FEBS Lett 220:187-92. 1987.... - RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currentsO Saitoh
Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu shi, Tokyo 183 8526, Japan
J Biol Chem 274:9899-904. 1999..These acceleration properties of RGS proteins may play important roles in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations...
Research Grants
- Structure and mechanism of beta2-adrenergic receptorRoger Sunahara; Fiscal Year: 2007..Finally, I will integrate these data to formulate a model of how hormone activation of beta2R leads to activation of nucleotide exchange and propose that this model will extend to the entire family of GPCRs. ..
- GPCR signaling complexes in living cellsNevin Lambert; Fiscal Year: 2009..g. when and where receptors, G-proteins and effector molecules interact with each other to transmit signals. The goal of this project is to provide this information. ..
- GPCR signaling complexes in living cellsNEVIN ALAN LAMBERT; Fiscal Year: 2010..g. when and where receptors, G-proteins and effector molecules interact with each other to transmit signals. The goal of this project is to provide this information. ..
- GPCR signaling complexes in living cellsNevin Lambert; Fiscal Year: 2009..g. when and where receptors, G-proteins and effector molecules interact with each other to transmit signals. The goal of this project is to provide this information. ..
- Regulation of G-protein signaling in CNS neuronsNevin Lambert; Fiscal Year: 2006..If our hypothesis is correct, we will identify presynaptic terminals as key sites for the adaptive changes responsible for the development of drug effects, drug tolerance and drug dependence. ..
- CALCIUM AND ENDOCYTOTIC MEMBRANE RETRIEVALNevin Lambert; Fiscal Year: 2003..Specifically we will determine how exocytotic activity influences membrane depolarization and the cellular distribution of P-type calcium channels. ..
- GPCR signaling complexes in living cellsNEVIN ALAN LAMBERT; Fiscal Year: 2010..g. when and where receptors, G-proteins and effector molecules interact with each other to transmit signals. The goal of this project is to provide this information. ..