GMCL1

Summary

Gene Symbol: GMCL1
Description: germ cell-less, spermatogenesis associated 1
Alias: BTBD13, GCL, GCL1, SPATA29, germ cell-less protein-like 1, germ cell-less homolog 1, spermatogenesis associated 29
Species: human
Products:     GMCL1

Top Publications

  1. Holaska J, Lee K, Kowalski A, Wilson K. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem. 2003;278:6969-75 pubmed
    ..quot;unascribed" domains of emerin mediate direct binding to a transcriptional repressor, germ cell-less (GCL). GCL co-immunoprecipitates with emerin from HeLa cells...
  2. de la Luna S, Allen K, Mason S, La Thangue N. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 1999;18:212-28 pubmed
    ..Our study defines a new pathway of growth control that is integrated with the E2F pathway through the DP subunit of the heterodimer. ..
  3. Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
    ..protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein...
  4. Kaliszewski M, Kennedy A, Blaes S, Shaffer R, Knott A, Song W, et al. SOD1 Lysine 123 Acetylation in the Adult Central Nervous System. Front Cell Neurosci. 2016;10:287 pubmed publisher
    ..In the cerebellum, Ac-K123 SOD1 staining was prominent in cell bodies of the granular cell layer (GCL) and Purkinje cell dendrites and interneurons of the molecular cell layer...
  5. Naik P, Sajja R, Prasad S, Cucullo L. Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line. BMC Neurosci. 2015;16:38 pubmed publisher
    ..quinone 1 (NQO-1), heme oxygenase-1 (HMOX-1), catalytic and modifier subunits of glutamate-cysteine ligase (GCL), solute carrier-SLC7A11)...
  6. Rothmiller S, Schröder S, Strobelt R, Wolf M, Wang J, Jiang X, et al. Sulfur mustard resistant keratinocytes obtained elevated glutathione levels and other changes in the antioxidative defense mechanism. Toxicol Lett. 2018;293:51-61 pubmed publisher
    ..S-transferase (GST) inhibition as well as activation and expression of Nrf2, GST, glutamate cysteine ligase (GCL) and glutathione-disulfide reductase (GSR) as well as multi-drug resistance (MDR) proteins 1, 3 and 5 were ..
  7. Yen J, Wu P, Chen S, Wu M. Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..the expression of nuclear E2 related factor (Nrf)2-targeted heme oxygenase (HO)-1, glutamate cysteine ligase (GCL) and cystine/glutamate transporter (xCT/SLC7A11), in both the presence and absence of Tm...
  8. Badiei A, Sudharsan R, Santana E, Dunaief J, Aguirre G. Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. Exp Eye Res. 2019;181:72-84 pubmed publisher
    ..retina: photoreceptors, outer plexiform layer (OPL) and notably in the ganglion cells layer/nerve fiber layer (GCL/NFL)...
  9. Zhou W, Zhang X, Cai Y, Sun W, Li H. Osthole prevents tamoxifen-induced liver injury in mice. Acta Pharmacol Sin. 2018;: pubmed publisher
    ..Consistently, osthole significantly enhanced the expressions of antioxidant genes (GPX1, SOD2, GCL-c, and G6pdh), but suppressed those of pro-oxidant genes (NOX2 and ACOX)...

More Information

Publications132 found, 100 shown here

  1. Smith M, Souza F, Bruce K, Strang C, Morley B, Keyser K. Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse. Mol Vis. 2014;20:1328-56 pubmed
    ..However, the retinal layers showed complex patterns of transcript expression. In the ganglion cell layer (GCL), m2 and m4 mAChR subtype transcripts were significantly upregulated, while β3 and β4 nAChR subunit ..
  2. Qian M, Lou Y, Wang Y, Zhang M, Jiang Q, Mo Y, et al. PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. Free Radic Biol Med. 2018;118:23-34 pubmed publisher
    ..BALF analysis, Hematoxylin and Eosin staining, TUNEL staining, maleimide staining, flow cytometry analysis, GCL, GSH, GSSG and cysteine levels measurement...
  3. Yu C, Pan S, Dong M, Niu Y. Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1195-1203 pubmed publisher
    ..Conversely, AS-IV had no effect on GCL modulatory subunit (GCLm) and superoxide dismutase (SOD) activity/expression...
  4. Sun H, Zhu X, Zhou Y, Cai W, Qiu L. C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction. Int J Mol Sci. 2017;18: pubmed publisher
    ..nicotinamide adenine dinucleotide phosphate (NAD(P)H) dehydrogenase quinone 1, and glutamate-cysteine ligase (GCL), as well as endothelial nitric oxide synthase (eNOS)...
  5. Muilu Mäkelä R, Vuosku J, Läärä E, Saarinen M, Heiskanen J, Häggman H, et al. Water availability influences morphology, mycorrhizal associations, PSII efficiency and polyamine metabolism at early growth phase of Scots pine seedlings. Plant Physiol Biochem. 2015;88:70-81 pubmed publisher
    ..catalase (CAT) late-embryogenesis abundant protein (LEA), pyruvate decarboxylase (PDC), glutamate-cysteine ligase (GCL) and glutathione synthetase (GS) genes...
  6. Jin C, Ou Q, Li Z, Wang J, Zhang J, Tian H, et al. The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells. Stem Cell Res Ther. 2018;9:346 pubmed publisher
    ..Transplanted cells can migrate into the retina, mainly into the inner cell layer (INL) and ganglion cell layer (GCL). Some cells can differentiate into astrocytes and amacrine cells...
  7. McAllister I, Vijayasekaran S, Zhang D, McLenachan S, Chen F, Yu D. Neuronal degeneration and associated alterations in cytokine and protein in an experimental branch retinal venous occlusion model. Exp Eye Res. 2018;174:133-146 pubmed publisher
    ..TUNEL labelling showed positive nuclei in the ganglion cell layer (GCL) and the inner nuclear layer (INL) which was significantly higher at 2 days after BRVO compared to other time ..
  8. de Oliveira M, Peres A, Ferreira G. Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway. Neurochem Res. 2017;42:1057-1072 pubmed publisher
    ..GCLM) subunits of the rate-limiting enzyme in the synthesis of glutathione (GSH), ?-glutamate-cysteine ligase (?-GCL). Nonetheless, it is not clear how PB exerts mitochondrial protection in mammalian cells...
  9. Pyo M, Yang S, Chun S, Oh N, Lee K. Protective Effects of Maillard Reaction Products of Whey Protein Concentrate against Oxidative Stress through an Nrf2-Dependent Pathway in HepG2 Cells. Biol Pharm Bull. 2016;39:1437-47 pubmed publisher
    ..phosphate (NAD(P)H)-quinone oxidoreductase 1 (NOQ1), heme oxygenase-1 (HO-1), glutamate-L-cysteine ligase (GCL)M and GCLC mRNA levels were increased by Glc-WPC...
  10. Markand S, Saul A, Tawfik A, Cui X, Rozen R, Smith S. Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice. Exp Eye Res. 2016;145:164-172 pubmed publisher
    ..thinner nerve fiber layer, focal areas of vascular leakage and 20% fewer cells in the ganglion cell layer (GCL)...
  11. Klein R, Rosa C, Colares E, Robaldo R, Martinez P, Bianchini A. Antioxidant defense system and oxidative status in Antarctic fishes: The sluggish rockcod Notothenia coriiceps versus the active marbled notothen Notothenia rossii. J Therm Biol. 2017;68:119-127 pubmed publisher
    ..gill enzyme [glutamate-cysteine ligase (GSL), superoxide dismutase (SOD) and catalase (CAT)] activity; liver GCL and SOD activity; and white muscle CAT activity were higher in N. rossii than in N. coriiceps...
  12. Jarolim K, Wolters K, Woelflingseder L, Pahlke G, Beisl J, Puntscher H, et al. The secondary Fusarium metabolite aurofusarin induces oxidative stress, cytotoxicity and genotoxicity in human colon cells. Toxicol Lett. 2018;284:170-183 pubmed publisher
    ..The GSSG/GSH ratio was elevated, but no impact on redox-sensitive Nrf2-dependent genes (Nrf2, γ-GCL, NQO1) was found at the gene expression level...
  13. Stanescu Segall D, Birke K, Wenzel A, Grimm C, Orgul S, Fischer J, et al. PAX6 Expression and Retinal Cell Death in a Transgenic Mouse Model for Acute Angle-Closure Glaucoma. J Glaucoma. 2015;24:426-32 pubmed publisher
    ..mice showed normal retinal morphology between p22 and p428 with steady PAX6 expression in the ganglion cell layer (GCL) and the inner nuclear layer (INL)...
  14. Camerino G, Desaphy J, De Bellis M, Capogrosso R, Cozzoli A, Dinardo M, et al. Effects of Nandrolone in the Counteraction of Skeletal Muscle Atrophy in a Mouse Model of Muscle Disuse: Molecular Biology and Functional Evaluation. PLoS ONE. 2015;10:e0129686 pubmed publisher
    ..of ND on the change of muscle phenotype induced by HU, since no effect of treatment was observed on the resting gCl, restCa and contractile properties in Sol muscle...
  15. Huang S, Huang P, Lin Z, Liu X, Xu X, Guo L, et al. Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma. Exp Eye Res. 2018;168:33-48 pubmed publisher
    ..the apoptosis of RGC isolated from experimented rats as well as apoptosis of neurons in ganglion cell layer (GCL), intrinsic apoptotic pathway activity, mitochondrial function, glial activation, NF-κB pathway activity, NADPH ..
  16. Myrum C, Soule J, Bittins M, Cavagnini K, Goff K, Ziemek S, et al. Arc Interacts with the Integral Endoplasmic Reticulum Protein, Calnexin. Front Cell Neurosci. 2017;11:294 pubmed publisher
    ..anesthetized rats, enhanced interaction between Arc and calnexin was obtained in the dentate granule cell layer (GCL)...
  17. Chen H, Huang C, Li C, Lin A, Huang Y, Wang T, et al. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol. 2014;280:1-9 pubmed publisher
    ..The results showed that andrographolide up-regulated glutamate cysteine ligase (GCL) catalytic and modifier subunits, superoxide dismutase (SOD)-1, heme oxygenase (HO)-1, and glutathione (GSH) S-..
  18. Arús B, Souza D, Bellaver B, Souza D, Goncalves C, Quincozes Santos A, et al. Resveratrol modulates GSH system in C6 astroglial cells through heme oxygenase 1 pathway. Mol Cell Biochem. 2017;428:67-77 pubmed publisher
    ..BSO exposure resulted in several detrimental effects, decreasing glutamate-cysteine ligase (GCL) activity, cystine uptake, GSH intracellular content and the activities of the antioxidant enzymes glutathione ..
  19. Liu R, Wang Y, Pu M, Gao J. Effect of alpha lipoic acid on retinal ganglion cell survival in an optic nerve crush model. Mol Vis. 2016;22:1122-1136 pubmed
    ..labeling showed that EPOR and NT4/5 expression was significant in the retinal ganglion cell layer (GCL)...
  20. Pfeiffer V, Götz R, Camarero G, Heinsen H, Blum R, Rapp U. Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF. PLoS ONE. 2018;13:e0192067 pubmed publisher
    ..the general morphology of the hippocampus was unchanged, CRAF-deficient mice displayed smaller granule cell layer (GCL) volume at postnatal day 30 (P30)...
  21. Knier B, Rothhammer V, Heink S, Puk O, Graw J, Hemmer B, et al. Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. J Autoimmun. 2015;56:34-44 pubmed publisher
    ..thickness of the retinal nerve fiber layer (RNFL) and the common layer of ganglion cells and inner plexiform layer (GCL+) after the recovery from motor symptoms indicating that autoimmune inflammation induced a significant atrophy of ..
  22. Zapatero Solana E, García Giménez J, Guerrero Aspizua S, García M, Toll A, Baselga E, et al. Oxidative stress and mitochondrial dysfunction in Kindler syndrome. Orphanet J Rare Dis. 2014;9:211 pubmed publisher
    ..oxidative stress biomarkers including MDA (malondialdehyde), GSSG/GSH ratio (oxidized and reduced glutathione) and GCL (gamma-glutamyl cysteine ligase) subunits...
  23. Duan X, Li J, Zhang Y, Li W, Zhao L, Nie H, et al. Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice. Int Immunopharmacol. 2015;28:1059-67 pubmed publisher
    ..and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (..
  24. Laporte D, Valdés N, Gonzalez A, Sáez C, Zúñiga A, Navarrete A, et al. Copper-induced overexpression of genes encoding antioxidant system enzymes and metallothioneins involve the activation of CaMs, CDPKs and MEK1/2 in the marine alga Ulva compressa. Aquat Toxicol. 2016;177:433-40 pubmed publisher
    ..and l-galactono lactone dehydrogenase (l-gldh), in glutathione (GSH) synthesis, ?-glutamate-cysteine ligase (?-gcl) and glutathione synthase (gs), and metal-chelating proteins metallothioneins (mt) were identified...
  25. Jin S, Hwang Y, Choi C, Kim H, Kim S, Kim Y, et al. Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways. Food Chem Toxicol. 2017;100:138-148 pubmed publisher
    ..Nrf2 target genes hemeoxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate cysteine ligase (GCL)...
  26. de Oliveira M, Peres A, Ferreira G, Schuck P, Gama C, Bosco S. Carnosic Acid Protects Mitochondria of Human Neuroblastoma SH-SY5Y Cells Exposed to Paraquat Through Activation of the Nrf2/HO-1Axis. Mol Neurobiol. 2017;54:5961-5972 pubmed publisher
    ..detoxification enzymes, such as heme oxygenase-1 (HO-1), glutathione reductase (GR), ?-glutamate-cysteine ligase (?-GCL), and glutathione S-transferase (GST), among others...
  27. Cheng G, Tian K, Zhang L, Yang N, Xing Y, He T. S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression. Graefes Arch Clin Exp Ophthalmol. 2016;254:97-108 pubmed publisher
    ..by the green fluorescent protein (GFP) in many layers of the retina, including the ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL)..
  28. Guerrera M, Abbate F, di Caro G, Germana G, Levanti M, Micale V, et al. Localization of cholecystokinin in the zebrafish retina from larval to adult stage. Ann Anat. 2018;218:175-181 pubmed publisher
    ..in the outer plexiform layer, in the inner plexiform layer and, to a lesser extent, in the ganglion cell layer (GCL)...
  29. Nishimoto S, Koike S, Inoue N, Suzuki T, Ogasawara Y. Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. Biochem Biophys Res Commun. 2017;483:874-879 pubmed publisher
    ..pre-treatment with the Nrf2 activator did not affect mRNA levels of GLO1, AKR1B1, and AKR7A2, the expressions of GCL and xCT mRNA, involved in GSH synthesis, were induced prior to increase in GSH levels...
  30. Mimura Yamamoto Y, Shinohara H, Kashiwagi T, Sato T, Shioda S, Seki T. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development. Sci Rep. 2017;7:5647 pubmed publisher
    ..GCPs) arising in the ventricular zone (VZ) migrate to the subpial region, and form the granule cell layer (GCL) of the dentate gyrus (DG)...
  31. Yan B, Jeon Y, Park J, Kim I, Cho J, Ahn J, et al. Increased cyclooxygenase-2 and nuclear factor-κB/p65 expression in mouse hippocampi after systemic administration of tetanus toxin. Mol Med Rep. 2015;12:7837-44 pubmed publisher
    ..COX‑2 immunoreactivity was increased by TeT in the SP and granule cell layer (GCL) of the DG in a time‑dependent manner...
  32. Abdel Hamid A, Firgany A, Ali E. Effect of memantine: A NMDA receptor blocker, on ethambutol-induced retinal injury. Ann Anat. 2016;204:86-92 pubmed publisher
    ..In the ETM group, the neural retina became significantly thinner (p<0.05) and the ganglion cell layer (GCL) was the main layer affected in the form of a significant decrease (p<0...
  33. Rosa P, Martins L, Souza D, Quincozes Santos A. Glioprotective Effect of Resveratrol: an Emerging Therapeutic Role for Oligodendroglial Cells. Mol Neurobiol. 2018;55:2967-2978 pubmed publisher
    ..reactive oxygen species (ROS) as well as the decrease in glutathione (GSH) levels and in glutamate cysteine ligase (GCL) activity, through Nrf2/HO-1 signaling pathways...
  34. Tak A, Sengul Y, Bilak S. Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients. Neurol Sci. 2018;39:489-496 pubmed publisher
    The aim of our study is to assess retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), inner-plexiform layer (IPL), and choroidal layer in migraine patients with white matter lesion (WML) or without WML, using spectral domain ..
  35. Dafré A, Goldberg J, Wang T, Spiegel D, Maher P. Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells. Free Radic Biol Med. 2015;89:8-19 pubmed publisher
    ..The increased cystine import (system xc(-)) activity and GCL expression promoted GSH synthesis, leading to increased levels of GSH...
  36. Liu X, Yang X, Zhu R, Dai M, Zhu M, Shen Y, et al. Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat Light-Induced Retina Damage Model. Cell Mol Neurobiol. 2017;37:83-92 pubmed publisher
    ..Immunostaining indicated that increased Fra-1 was mainly expressed in RGCs in retinal ganglion cell layer (GCL) after LE. Co-localization of Fra-1 with active caspase-3 or TUNEL-positive cells in GCL after LE was also detected...
  37. Watanabe Y, Murakami T, Kawashima M, Hasegawa Baba Y, Mizukami S, Imatanaka N, et al. Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring. Neurotox Res. 2017;31:46-62 pubmed publisher
    ..In the subgranular zone (SGZ) and granule cell layer (GCL) of offspring, the number of granule cell lineage subpopulations remained unchanged upon weaning...
  38. Jeong M, Jeon C. Localization of melanopsin-immunoreactive cells in the Mongolian gerbil retina. Neurosci Res. 2015;100:6-16 pubmed publisher
    ..Melanopsin-IR cells were primarily located in the ganglion cell layer (GCL; M1c; 75.15%). Many melanopsin-IR cells were also observed in the inner nuclear layer (INL; M1d; 22.28%)...
  39. Jeong M, Kim H, Jeon C. The organization of melanopsin-immunoreactive cells in microbat retina. PLoS ONE. 2018;13:e0190435 pubmed publisher
    ..M1 soma locations were identified either in the ganglion cell layer (GCL, M1c; 21.00%) or in the inner nuclear layer (INL, M1d; 5.15%)...
  40. Yiu G, Wang Z, Munevar C, Tieu E, Shibata B, Wong B, et al. Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res. 2018;168:69-76 pubmed publisher
    ..We found that histological sections provide better distinction between the ganglion cell layer (GCL) and inner plexiform layer (IPL) than SD-OCT imaging...
  41. Jeske M, Bordi M, Glatt S, Müller S, Rybin V, Müller C, et al. The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities. Cell Rep. 2015;12:587-98 pubmed publisher
    ..Our findings suggest a dual function of Oskar in RNA and Vasa binding, providing molecular clues to its germ plasm function. ..
  42. Caldera H, De Costa W, Woodward F, Lake J, Ranwala S. Effects of elevated carbon dioxide on stomatal characteristics and carbon isotope ratio of Arabidopsis thaliana ecotypes originating from an altitudinal gradient. Physiol Plant. 2017;159:74-92 pubmed publisher
    ..the effects of CO2 enrichment (CE) on stomatal density (SD)-related properties, guard cell length (GCL) and carbon isotope ratio (?13 C) of a range of Arabidopsis thaliana ecotypes originating from a wide ..
  43. Cooley L. How Primordial Germ Cells Destroy Somatic Signals. Dev Cell. 2017;42:107-108 pubmed publisher
    The Germ Cell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embryos. Reporting in this issue of Developmental Cell, Pae et al...
  44. Acer S, Oğuzhanoğlu A, Çetin E, Ongun N, Pekel G, Kaşıkçı A, et al. Ocular pulse amplitude and retina nerve fiber layer thickness in migraine patients without aura. BMC Ophthalmol. 2016;16:1 pubmed publisher
    ..asymmetry analysis (PPAA), the peripapillary retinal nerve fiber layer (RNFL) thickness, the ganglion cell layer (GCL) thickness, macular thickness and visual field testing in migraine patients without aura...
  45. Goddard Borger E, Tysoe C, Withers S. Glycosynthase mediated synthesis of psychosine. Carbohydr Res. 2016;435:97-99 pubmed publisher
    Globoid cell leukodystrophy (GCL), or Krabbe disease, is a lysosomal storage disorder characterized by a deficiency in galactosylceramidase (GALC), which hydrolyses galactosylceramide and galactosylsphingosine (psychosine)...
  46. Zhang H, Zhou L, Yuen J, Birkner N, Leppert V, O Day P, et al. Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles. Free Radic Biol Med. 2017;108:311-319 pubmed publisher
    ..e., glutamate cysteine ligase (GCL) catalytic subunit (GCLC), GCL modifier subunit (GCLM), heme oxygenase 1 (HO-1), and NAD(P)H:quinone oxidoreductase-..
  47. Gulmez Sevim D, Unlü M, Gultekin M, Karaca C. Retinal single-layer analysis with optical coherence tomography shows inner retinal layer thinning in Huntington's disease as a potential biomarker. Int Ophthalmol. 2019;39:611-621 pubmed publisher
    ..Temporal pRNFL, macular RNFL (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer and outer plexiform layer thicknesses and IPL, retinal pigment ..
  48. Garcia Medina J, del Río Vellosillo M, Palazón Cabanes A, Tudela Molino M, Gómez Molina C, Guardiola Fernández A, et al. Mapping the thickness changes on retinal layers segmented by spectral-domain optical coherence tomography using the posterior pole program in glaucoma. Arch Soc Esp Oftalmol. 2018;93:263-273 pubmed publisher
    ..segmented by prototype software, obtaining: a macular retinal nerve fibre layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform+nuclear layer, photoreceptor layer, ..
  49. Dequanter D, Van de Velde M, Bar I, Nuyens V, Rousseau A, Nagy N, et al. Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. Oncol Lett. 2016;11:3660-3668 pubmed
    ..purpose of the present cross-sectional study was to evaluate whether the expression of glutamate-cysteine ligase (GCL) accounts for the increased GSH availability observed in HN squamous cell carcinoma (SCC)...
  50. Lambuk L, Jafri A, Arfuzir N, Iezhitsa I, Agarwal R, Rozali K, et al. Neuroprotective Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity in Rat Retina. Neurotox Res. 2017;31:31-45 pubmed publisher
    ..The retinal morphometry showed reduced thickness of ganglion cell layer (GCL) and reduction in the number of retinal cells in GCL in NMDA group compared to the MgAT-treated groups...
  51. Said A, Elbayomi A, Shaat A. Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study. BMC Ophthalmol. 2017;17:251 pubmed publisher
    ..In study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ?0...
  52. Estep J, Wong W, Wong Y, Loui B, Riccomagno M. The RacGAP β-Chimaerin is essential for cerebellar granule cell migration. Sci Rep. 2018;8:680 pubmed publisher
    ..radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL)...
  53. Keller J, Oakley J, Russakoff D, Andorrà Inglés M, Villoslada P, Sánchez Dalmau B. Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2016;254:561-7 pubmed publisher
    ..7 SD) in the fellow eye (p < 0.001). After 1 month, the RNFL and the ganglion cell layer (GCL) were thinned 17.7 % [to 31.2 μm (±6.4 SD), p < 0.001] and 19.3 % [to 66.5 μm (±7...
  54. Kupersmith M, Garvin M, Wang J, Durbin M, Kardon R. Retinal ganglion cell layer thinning within one month of presentation for optic neuritis. Mult Scler. 2016;22:641-8 pubmed publisher
    ..Spectral domain optical coherence tomography (SD-OCT) reveals retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) and peripapillary retinal nerve fiber layer (pRNFL) thinning in chronic optic nerve injury...
  55. Funke S, Perumal N, Beck S, Gabel Scheurich S, Schmelter C, Teister J, et al. Glaucoma related Proteomic Alterations in Human Retina Samples. Sci Rep. 2016;6:29759 pubmed publisher
    ..by Accurate Inclusion Mass Screening (AIMS) and immunostaining and supported for the retinal ganglion cell layer (GCL) by laser capture microdissection (LCM) in porcine and human eye cryosections...
  56. Gábriel R, Erdélyi F, Szabó G, Lawrence J, Wilhelm M. Ectopic transgene expression in the retina of four transgenic mouse lines. Brain Struct Funct. 2016;221:3729-41 pubmed publisher
    ..Occasionally, we found GFP/CALR and GFP/PV double-stained cells in the ganglion cell layer (GCL). In the GAD65-GFP construct, all layers of the neuroretina were labeled, except photoreceptors...
  57. Ávila Mendoza J, Mora J, Carranza M, Luna M, Aramburo C. Growth hormone reverses excitotoxic damage induced by kainic acid in the green iguana neuroretina. Gen Comp Endocrinol. 2016;234:57-67 pubmed publisher
    ..neurons present in several layers of the neuroretina (inner nuclear [INL], outer nuclear [ONL] and ganglion cell [GCL] layers) as determined by its co-existence with NeuN, but not in glial cells...
  58. Reid M, O DONOVAN M, Murphy J, Fleming C, Kennedy E, Lewis E. The effect of high and low levels of supplementation on milk production, nitrogen utilization efficiency, and milk protein fractions in late-lactation dairy cows. J Dairy Sci. 2015;98:5529-44 pubmed publisher
    ..to 1 of 6 treatments [high grass allowance (HG), low grass allowance (LG), grass with a low concentrate allocation (GCL), grass with a low grass silage allocation (GSL), grass with a high concentrate allocation (GCH), and grass with a ..
  59. Tu H, Hsu C, Chen Y, Chen C. Patch Clamp Recording of Starburst Amacrine Cells in a Flat-mount Preparation of Deafferentated Mouse Retina. J Vis Exp. 2016;: pubmed publisher
    ..We have optimized a flat-mount preparation for patch clamp recording of genetically marked neurons in both GCL (ganglion cell layer) and INL (inner nuclear layer) of mouse retinas...
  60. Lu C, Zou Y, Liu Y, Niu Y. Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system. Toxicol Appl Pharmacol. 2017;318:69-78 pubmed publisher
    ..2 (Nrf2) and catalytic subunits from glutamate cysteine ligase (GCLc) expression, but not modulatory subunits from GCL (GCLm). RA-mediated up-regulation of GClc is inhibited by the shRNA-induced Nrf2 knockdown...
  61. Xu W, Jia H, Zhang L, Wang H, Tang H, Zhang L. Effects of GSH1 and GSH2 Gene Mutation on Glutathione Synthetases Activity of Saccharomyces cerevisiae. Protein J. 2017;36:270-277 pubmed publisher
    ..L51 is located adjacently to the two active sites of GCL/E/Mg2+/ADP complex in the overall GCL structure...
  62. Kim E, Park H, Park C. Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma. Sci Rep. 2017;7:5543 pubmed publisher
    ..This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL)..
  63. Nicola Z, Fabel K, Kempermann G. Development of the adult neurogenic niche in the hippocampus of mice. Front Neuroanat. 2015;9:53 pubmed publisher
    ..Intermediate progenitor cell marker Tbr2 became restricted to the SGZ but was found in the granule cell layer (GCL) and hilus before. Lineage markers NeuroD1 and Prox1 confirmed this pattern...
  64. Cen L, Han M, Zhou L, Tan L, Liang J, Pang C, et al. Bilateral retinal microglial response to unilateral optic nerve transection in rats. Neuroscience. 2015;311:56-66 pubmed publisher
    ..12 weeks, along with dramatic inverted alteration of process branch points of microglia in the ganglion cell layer (GCL)...
  65. Xu X, Yu H, Yang Y, Hang L, Yang X, Ding S. Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway. Eur J Pharmacol. 2016;770:1-8 pubmed publisher
    ..activated Nrf2 nuclear translocation and significantly enhanced the expression of target genes HO-1, NQO-1 and GCL by different folds at both mRNA and protein levels...
  66. Liao M, Peng W, Kan D, Chien C. Developmental pattern of the neuronal intermediate filament inaa in the zebrafish retina. J Comp Neurol. 2016;524:3810-3826 pubmed publisher
    ..in retinal neuroepithelial cells at 1 day postfertilization (dpf), and was mainly found in the ganglion cell layer (GCL) and inner part of the inner nuclear layer (INL) from 3-9 dpf; after 14 dpf, it was restricted to the outer nuclear ..
  67. Sepah Y, Sadiq M, Hassan M, Hanout M, Soliman M, Agarwal A, et al. Assessment of Retinal Structural and Functional Characteristics in Eyes with Autoimmune Retinopathy. Curr Mol Med. 2015;15:578-86 pubmed
    ..complex), photoreceptor layer (PRL), inner nuclear layer (INL), combined ganglion cell and inner plexiform layers (GCL+), nerve fiber layer (NFL), and combined GCL+ and NFL layers (GCL+/NFL)...
  68. Zhang H, Liu H, Zhou L, Yuen J, Forman H. Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. Free Radic Biol Med. 2017;113:304-310 pubmed publisher
    ..in the intracellular glutathione (GSH), the master antioxidant, and the expression of glutamate cysteine ligase (GCL), the rate-limiting enzyme for GSH biosynthesis, in the inflammatory response of human macrophages (THP1 cells) to ..
  69. Feary M, Racher A, Young R, Smales C. Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis. Biotechnol Prog. 2017;33:17-25 pubmed publisher
    ..However, MSX is not a specific inhibitor of GS as it also inhibits the activity of GCL (a key enzyme in the glutathione biosynthesis pathway) to a similar extent...
  70. Roberts J, Atanasova K, Lee J, Diamond G, Deguzman J, Hee Choi C, et al. Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells. Front Cell Infect Microbiol. 2017;7:291 pubmed publisher
    ..05) in glutamate cysteine ligase (GCL) subunits GCLc and GCLm, glutathione synthetase, and glutathione reductase during the infection. These suggest P...
  71. Radic T, Frieß L, Vijikumar A, Jungenitz T, Deller T, Schwarzacher S. Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats. Front Neuroanat. 2017;11:104 pubmed publisher
    ..in both mice and rats, when young, immature DCX-positive GCs became confined to the innermost part of the GC layer (GCL), indicative of the formation of the SGZ...
  72. Güneş A, Karadağ A, Yazgan S, Celik H, Simşek A. Evaluation of retinal nerve fibre layer, ganglion cell layer and choroidal thickness with optical coherence tomography in migraine patients: a case-control study. Clin Exp Optom. 2018;101:109-115 pubmed publisher
    Evaluation of retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and choroidal thickness (CT) with optical coherence tomography (OCT) in chronic migraine patients, to compare with healthy controls.
  73. Mutlu U, Bonnemaijer P, Ikram M, Colijn J, Cremers L, Buitendijk G, et al. Retinal neurodegeneration and brain MRI markers: the Rotterdam Study. Neurobiol Aging. 2017;60:183-191 pubmed publisher
    ..Thickness of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer were measured on OCT images...
  74. Kim S, Yoon D, Lee Y, Lee J, Kim N, Kim S, et al. Transformation of liver cells by 3-methylcholanthrene potentiates oxidative stress via the downregulation of glutathione synthesis. Int J Mol Med. 2017;40:2011-2017 pubmed publisher
    ..These changes were accompanied by a significantly reduced expression of ?-glutamylcysteine ligase (GCL), known to be the rate?limiting step of GSH synthesis...
  75. Park J, Park G, Kim J. Osterix is dispensable for the development of the mouse olfactory bulb. Biochem Biophys Res Commun. 2016;478:110-115 pubmed publisher
    ..showed neuronal cell alterations caused by Osx deficiency in the mitral cell layer (MCL) and granule cell layer (GCL) of the olfactory bulb at postnatal stage...
  76. Li C, Zhang W, Choi J, Frei B. Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. Redox Biol. 2016;9:220-228 pubmed publisher
    ..Furthermore, quercetin slightly but significantly increased mRNA and protein levels of glutamate-cysteine ligase (GCL) catalytic and modifier subunits...
  77. Cao W, Hong Y, Chen H, Wu F, Wei X, Ying W. SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells. FEBS Lett. 2016;590:2241-55 pubmed publisher
    ..SIRT2 siRNA also blocked the NADH-induced increases in glutamate cysteine ligase (GCL) and glutathione...
  78. Gilmer J, Person A. Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity. J Neurosci. 2017;37:12153-12166 pubmed publisher
    Combinatorial expansion by the cerebellar granule cell layer (GCL) is fundamental to theories of cerebellar contributions to motor control and learning...
  79. Ramkumar H, Nguyen B, Bartsch D, Saunders L, Muftuoglu I, You Q, et al. REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY. Retina. 2017;: pubmed publisher
    ..The purpose of this study is to determine whether ganglion cell layer (GCL) volume is reduced in GA using manual analysis.
  80. Dahmen B, Puetz V, Scharke W, von Polier G, Herpertz Dahlmann B, Konrad K. Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions. Dev Neurosci. 2017;: pubmed publisher
    ..stress-sensitive hippocampal subfields (Cornu ammonis [CA]1, CA3, and the granule-cell layer of the dentate gyrus [GCL-DG]) were significantly smaller in children who had experienced ELA, taking psychiatric diagnoses and dimensional ..
  81. Nieto Estévez V, Oueslati Morales C, Li L, Pickel J, Morales A, Vicario Abejón C. Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis. Stem Cells. 2016;34:2194-209 pubmed publisher
    ..of Tbr2(+) -intermediate neuronal progenitors, some of which were displaced in the outer granule cell layer (GCL) and the molecular layer (ML) of the dentate gyrus (DG)...
  82. Yu H, Liang H, Qu F, He J, Xu G, Hu H, et al. Biofouling control by biostimulation of quorum-quenching bacteria in a membrane bioreactor for wastewater treatment. Biotechnol Bioeng. 2016;113:2624-2632 pubmed publisher
    ..In plant research, gamma-caprolactone (GCL), which is structurally similar to the quorum signal, N-acyl homoserine lactone (AHL), was successfully used to ..
  83. Park E, Gu Y, Jeon C. Immunocytochemical localization of cholinergic amacrine cells in the bat retina. Acta Histochem. 2017;119:428-437 pubmed publisher
    ..These ChAT-IR cells were present in the ganglion cell layer (GCL) and inner part of the inner nuclear layer (INL), as previously reported in various animals...
  84. Pae J, Cinalli R, Marzio A, Pagano M, Lehmann R. GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK. Dev Cell. 2017;42:130-142.e7 pubmed publisher
    ..Here, we show that Drosophila Germ cell-less (GCL) is a critical component in this process by acting as a switch that turns off a somatic lineage pathway...
  85. Williams K, Rosen L, Pilkinton M, Dhariwal L, Winkler H. Putting POP-Q to the test: does C - D = cervical length?. Int Urogynecol J. 2018;29:881-885 pubmed publisher
    We investigated the correlation between calculated cervical length (CCL) and gross specimen cervical length (GCL) after total vaginal hysterectomy (TVH) at the time of surgery for pelvic organ prolapse (POP)...
  86. Jang J, Lee M, Cho K. Comparative analysis of mean retinal thickness measured using SD-OCT in normal young or old age and glaucomatous eyes. Int Ophthalmol. 2018;38:2417-2426 pubmed publisher
    To evaluate changes in macular thickness, ganglion cell layer/inner plexiform layer (GCL/IPL) thickness, and retinal nerve fiber layer (RNFL) thickness in normal eyes and glaucomatous eyes using spectral domain optical coherence ..
  87. Feng W, Rosca M, Fan Y, Hu Y, Feng P, Lee H, et al. Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration. Hum Mol Genet. 2017;26:1376-1390 pubmed publisher
    Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular glutathione (GSH) synthesis...
  88. Kleiman S, Yogev L, Gal Yam E, Hauser R, Gamzu R, Botchan A, et al. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. J Androl. 2003;24:670-5 pubmed
    Germ cell-less (GCL) protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologues. In Drosophila, maternal GCL protein is required to establish the germ lineage during embryonic development...
  89. Geihs M, Vargas M, Maciel F, Vakkuri O, Meyer Rochow V, Allodi S, et al. Effects of hypoxia and reoxygenation on the antioxidant defense system of the locomotor muscle of the crab Neohelice granulata (Decapoda, Varunidae). J Comp Physiol B. 2016;186:569-79 pubmed publisher
    ..GPx), and glutathione-S-transferase as well as the key enzyme of glutathione synthesis, glutamate cysteine ligase (GCL), were evaluated...
  90. Qin S, Ware S, Waclaw R, Campbell K. Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2. Neural Dev. 2017;12:13 pubmed publisher
    ..toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL)...
  91. Masuhara M, Nagao K, Nishikawa M, Kimura T, Nakano T. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem Biophys Res Commun. 2003;308:927-32 pubmed
    ..In addition, the amount of p53 was increased and transactivation by p53 was enhanced by mGCL-1. Thus, mGCL-1 turned out to be a factor modulating MDM2-p53 axis by enhanced degradation of MDM2. ..
  92. Langouet Astrie C, Yang Z, Polisetti S, Welsbie D, Hauswirth W, Zack D, et al. Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells. Exp Eye Res. 2016;151:61-7 pubmed publisher
    ..10(9) vector genomes (vg) were sufficient for effective in vivo targeting of murine ganglion cell layer (GCL) retinal neurons...