GM130

Summary

Gene Symbol: GM130
Description: golgin A2
Alias: GM130, golgin subfamily A member 2, 130 kDa cis-Golgi matrix protein, GM130 autoantigen, Golgi matrix protein GM130, SY11 protein, golgi autoantigen, golgin subfamily a, 2, golgin-95
Species: human
Products:     GM130

Top Publications

  1. Fritzler M, Hamel J, Ochs R, Chan E. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. J Exp Med. 1993;178:49-62 pubmed
    ..The SY11 protein was provisionally named golgin-95 and the SY2/SY10 protein was named golgin-160...
  2. Nakamura N, Rabouille C, Watson R, Nilsson T, Hui N, Slusarewicz P, et al. Characterization of a cis-Golgi matrix protein, GM130. J Cell Biol. 1995;131:1715-26 pubmed
    ..A full-length clone was obtained encoding a protein of 130 kD (termed GM130), the COOH-terminal domain of which was highly homologous to a Golgi human auto-antigen, golgin-95 (Fritzler et al...
  3. Weide T, Bayer M, Koster M, Siebrasse J, Peters R, Barnekow A. The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. EMBO Rep. 2001;2:336-41 pubmed
    ..Two of them encode large protein fragments highly homologous to rat GM130 and to human Golgin95...
  4. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T. Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. FEBS Lett. 2001;508:201-9 pubmed
    ..stabilised in its GTP form was found to interact by Western blotting or mass spectroscopy with Golgi protein GM130 and rabaptin-5 and rabex-5, two rab effector molecules thought to function exclusively in the endocytic pathway...
  5. Weide T, Teuber J, Bayer M, Barnekow A. MICAL-1 isoforms, novel rab1 interacting proteins. Biochem Biophys Res Commun. 2003;306:79-86 pubmed
    Rab1 GTPases participate in regulating the vesicular transport of ER-Golgi compartments. Recently, GM130, p115, and Golgin-84 were identified as effectors of the active conformation of rab1...
  6. Barr F, Puype M, Vandekerckhove J, Warren G. GRASP65, a protein involved in the stacking of Golgi cisternae. Cell. 1997;91:253-62 pubmed
    ..One of the two minor targets of NEM is GM130, previously implicated in the docking of transport vesicles and mitotic fragmentation of the Golgi stack...
  7. Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y. Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane. J Biol Chem. 1998;273:5385-8 pubmed
    ..Taken together, these results suggest that the phosphorylation of Ser942 at the C-terminal acidic domain regulates the interaction of p115 with the Golgi membrane, possibly taking part in the regulatory mechanism of vesicular transport. ..
  8. Barr F, Nakamura N, Warren G. Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae. EMBO J. 1998;17:3258-68 pubmed
    ..containing GRASP65, a membrane protein involved in establishing the stacked structure of the Golgi apparatus, and GM130, a putative Golgi matrix protein and vesicle docking receptor, was investigated...
  9. Shorter J, Watson R, Giannakou M, Clarke M, Warren G, Barr F. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. EMBO J. 1999;18:4949-60 pubmed
    ..GRASP65 exists in a complex with the vesicle docking protein receptor GM130 to which it binds directly, and the membrane tethering protein p115, which also functions in the stacking of Golgi ..

More Information

Publications119 found, 100 shown here

  1. Linstedt A, Jesch S, Mehta A, Lee T, Garcia Mata R, Nelson D, et al. Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus. J Biol Chem. 2000;275:10196-201 pubmed
    By forming a molecular tether between two membranes, p115, giantin, and GM130 may mediate multiple Golgi-related processes including vesicle transport, cisternae formation, and cisternal stacking...
  2. Dirac Svejstrup A, Shorter J, Waters M, Warren G. Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments. J Cell Biol. 2000;150:475-88 pubmed
    ..can be tethered to Golgi membranes by a complex of fibrous, coiled-coil proteins comprising p115, Giantin and GM130. p115 has been postulated to act as a bridge, linking Giantin on the vesicle to GM130 on the Golgi membrane...
  3. Alvarez C, Garcia Mata R, Hauri H, Sztul E. The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic. J Biol Chem. 2001;276:2693-700 pubmed
    ..P115 interacts with two Golgi proteins, GM130 and giantin, suggesting that they might also participate in ER-Golgi traffic...
  4. Marra P, Maffucci T, Daniele T, Tullio G, Ikehara Y, Chan E, et al. The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment. Nat Cell Biol. 2001;3:1101-13 pubmed
    ..To gain insight into this step, we investigated the dynamics by which cis-Golgi matrix proteins such as GM130 and GRASP65 associate with, and incorporate, incoming IC elements...
  5. Rivero S, Cardenas J, Bornens M, Rios R. Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. EMBO J. 2009;28:1016-28 pubmed publisher
    ..Depletion of AKAP450 abolished MT nucleation at the Golgi, whereas depletion of the cis-Golgi protein GM130 led to the disorganisation of AKAP450 network and impairment of MT nucleation...
  6. Nakamura N, Lowe M, Levine T, Rabouille C, Warren G. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner. Cell. 1997;89:445-55 pubmed
    The docking of transport vesicles with their target membrane is thought to be mediated by p115. We show here that GM130, a cis-Golgi matrix protein, interacts specifically with p115 and so could provide a membrane docking site...
  7. Lowe M, Rabouille C, Nakamura N, Watson R, Jackman M, Jämsä E, et al. Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Cell. 1998;94:783-93 pubmed
    Mitotic fragmentation of the Golgi apparatus can be largely explained by disruption of the interaction between GM130 and the vesicle-docking protein p115...
  8. Barr F. A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. Curr Biol. 1999;9:381-4 pubmed
    ..This family includes golgin-230/245/256, golgin-97, GM130/golgin-95, golgin-160/MEA-2/GCP170, giantin/macrogolgin and a related group of proteins - possibly splice variants ..
  9. Moyer B, Allan B, Balch W. Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering. Traffic. 2001;2:268-76 pubmed
    ..Here, we demonstrate that the cis-Golgi tethering protein GM130, complexed with GRASP65 and other proteins, forms a novel Rab1 effector complex that interacts with activated Rab1-..
  10. Short B, Preisinger C, Korner R, Kopajtich R, Byron O, Barr F. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. J Cell Biol. 2001;155:877-83 pubmed
    ..rab1 regulates ER to Golgi transport by interaction with the vesicle tethering factor p115 and the cis-Golgi matrix protein GM130, also part of a complex with GRASP65 important for the organization of cis-Golgi cisternae...
  11. Jungk L, Franke H, Salameh A, Dhein S. Golgi Fragmentation in Human Patients with Chronic Atrial Fibrillation: A New Aspect of Remodeling. Thorac Cardiovasc Surg. 2019;67:98-106 pubmed publisher
    ..Tissue samples of the left atrial free wall were examined immunohistochemically. Golgi apparatus was detected by GM130 and its phosphorylated isoform. Furthermore, we investigated the length of the microtubules by α-tubulin staining...
  12. Song K, Gras C, Capin G, Gimber N, Lehmann M, Mohd S, et al. A SEPT1-based scaffold is required for Golgi integrity and function. J Cell Sci. 2019;132: pubmed publisher
    ..SEPT1 function depends on the Golgi matrix protein GM130 (also known as GOLGA2) and on centrosomal proteins, including CEP170 and components of γ-tubulin ring ..
  13. Wang C, Ye M, Zhao Q, Xia M, Liu D, He L, et al. Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy. Am J Nephrol. 2019;49:307-316 pubmed publisher
    ..modification is in Golgi, and downregulation of the Golgi peripheral membrane protein Golgi matrix protein 130 (GM130) could lead to glycosylation deficiency...
  14. Pan Z, Lu Y, Tang F, Pan M, Wan X, Lan M, et al. RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†. Biol Reprod. 2019;100:711-720 pubmed publisher
    ..Moreover, we demonstrated that RAB8A colocalized and interacted with GM130 at the spindle periphery and that RAB8A depletion caused the disruption of GM130-docked Golgi distribution...
  15. Bai Y, Wang J, Gao Z, Dai E. Identification and Verification of Two Novel Differentially Expressed Proteins from Non-neoplastic Mucosa and Colorectal Carcinoma Via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry. Pathol Oncol Res. 2019;: pubmed publisher
    ..Bioinformatics analysis revealed that golgin subfamily A member 2 (GOLGA2) and heterogeneous nuclear ribonucleoprotein D0 (hnRNPD) were located in the center of the ..
  16. Mencarelli C, Nitarska J, Kroecher T, Ferraro F, Massey K, Riccio A, et al. RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity. Cell Rep. 2018;24:2529-2539.e4 pubmed publisher
    ..Our results show that downstream of RanBP1, LKB1 function is mediated by the STK25-GM130 pathway, which promotes axonogenesis through Golgi regulation...
  17. Futel M, Le Bouffant R, Buisson I, Umbhauer M, Riou J. Characterization of potential TRPP2 regulating proteins in early Xenopus embryos. J Cell Biochem. 2018;119:10338-10350 pubmed publisher
    ..This was observed in KF cells, but does not appear to occur in the apical ciliated region of GRP cells. ..
  18. Roboti P, Sato K, Lowe M. The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway. J Cell Sci. 2015;128:1595-606 pubmed publisher
    ..Using co-depletion experiments, we also found that GMAP-210 acts in a partially redundant manner with the golgin GM130 to ensure efficient anterograde cargo delivery to the cis-Golgi...
  19. Kodani A, Kristensen I, Huang L, Sutterlin C. GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. Mol Biol Cell. 2009;20:1192-200 pubmed publisher
    ..demonstrate that the previously described regulation of centrosome organization and function by the Golgi protein, GM130, involves a Golgi-associated complex consisting of GM130, the Rho GTPase, Cdc42, and its guanine nucleotide ..
  20. Wiernasz E, Kaliszewska A, Brutkowski W, Bednarczyk J, Gorniak M, Kaza B, et al. Ttyh1 protein is expressed in glia in vitro and shows elevated expression in activated astrocytes following status epilepticus. Neurochem Res. 2014;39:2516-26 pubmed publisher
    ..staining using markers for the following subcellular structures: endoplasmic reticulum (GRP78), Golgi apparatus (GM130), clathrin-coated vehicles (clathrin), early endosomes (Rab5 and APPL2), recycling endosomes (Rab11), trans-Golgi ..
  21. Giacomello E, Ronchi P, Pepperkok R. GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation. J Cell Sci. 2019;: pubmed publisher
    ..We show that knock-down of p115 or GM130, two regulators of the early secretory pathway, impairs GC and ERES re-organisation...
  22. Cao Y, Du J, Chen D, Wang Q, Zhang N, Liu X, et al. RNA- binding protein Stau2 is important for spindle integrity and meiosis progression in mouse oocytes. Cell Cycle. 2016;15:2608-2618 pubmed
    ..and mitosis of BHK and MEF cells, Stau2 was not distributed on microtubules, but colocalized with cis-Golgi marker GM130, implying its association with Golgi complex but not the spindle in fully differentiated somatic cells...
  23. Brandon E, Szul T, Alvarez C, Grabski R, Benjamin R, Kawai R, et al. On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo. Mol Biol Cell. 2006;17:2996-3008 pubmed
    ..p115 mutant missing the GM130/giantin binding site exhibits analogous fluorescence recovery after photobleaching (FRAP) (t1/2 approximately 13 s)..
  24. Nevalainen M, Metsikkö K. Fluvastatin delays propagation of viral infection in isolated rat FDB myofibers but does not affect exocytic membrane trafficking. Cell Biol Int. 2015;39:1307-16 pubmed publisher
    ..that fluvastatin did not affect its distribution within the ER/SR network and immunofluorescence staining for GM130 did not show any marked effect on the structure of the Golgi components...
  25. Cardoso R, Wang J, Müller J, Rupp S, Leitão A, Hemphill A. Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Exp Parasitol. 2018;187:75-85 pubmed publisher
    ..caninum infected cells. In either case, the Golgi stacks of infected cells contained both cis- (GM130) and trans- (TGN46) Golgi proteins...
  26. Kostenko S, Heu C, Yaron J, Singh G, de Oliveira C, Muller W, et al. c-Src regulates cargo transit via the Golgi in pancreatic acinar cells. Sci Rep. 2018;8:11903 pubmed publisher
    ..While other Src family members had no effect on the Golgi markers P115 and GM130, active c-Src increased the Golgi area these stained, extending them into the ER...
  27. Marcassa E, Raimondi M, Anwar T, Eskelinen E, Myers M, Triolo G, et al. Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin. Biol Open. 2017;6:551-562 pubmed publisher
    ..Moreover, Atg9 and Bif-1 remain in the GM130-positive Golgi stacks and Atg9 fails to interact with the endocytic route marker transferrin receptor and with the ..
  28. Liu H, Wang H, Tang L, Yang Y, Wang Q, Zeng W, et al. Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations. Gene. 2015;563:35-40 pubmed publisher
    ..Val420Leu proteins were largely co-localized with both the protein disulfide isomerase (PDI) and cis-Golgi Marker (GM130), while the PC p.Asp297His mutant protein was mainly co-localized with PDI and much less co-localized with GM130...
  29. Frindt G, Gravotta D, Palmer L. Regulation of ENaC trafficking in rat kidney. J Gen Physiol. 2016;147:217-27 pubmed publisher
    ..Golgi membranes, isolated with an antibody against the cis-Golgi protein GM130, expressed both immature and processed γENaC; Na depletion increased the content of processed γENaC in this ..
  30. Peng X, Gao S, Deng H, Cai H, Zhou Z, Xiang R, et al. Perturbation of epithelial apicobasal polarity by rhomboid family-1 gene overexpression. FASEB J. 2018;32:5577-5586 pubmed publisher
    ..Consistently, RHBDF1 overexpression gives rise to disordered distribution of polarity markers GM130 and laminin-5, which otherwise are located in apical and basal positions, respectively, in the acini...
  31. Han F, Liu C, Zhang L, Zhou Y, Qin Y, Wang Y, et al. Globozoospermia and lack of acrosome formation in GM130-deficient mice. Cell Death Dis. 2017;8:e2532 pubmed publisher
    ..b>GM130 is a cis-side localized Golgi matrix protein,whereas the physiological functions of this protein remain elusive...
  32. Yokoyama C, Baldridge M, Leung D, Zhao G, Desai C, Liu T, et al. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem. 2018;293:6022-6038 pubmed publisher
    ..Mouse LysMD3 is a type II integral membrane protein that co-localizes with GM130+ structures, consistent with localization to the Golgi apparatus...
  33. Maddirevula S, Alzahrani F, Al Owain M, Al Muhaizea M, Kayyali H, Alhashem A, et al. Autozygome and high throughput confirmation of disease genes candidacy. Genet Med. 2019;21:736-742 pubmed publisher
    ..Our results should facilitate the timely relabeling of these candidate disease genes in relevant databases to improve the yield of clinical genomic sequencing. ..
  34. Baschieri F, Confalonieri S, Bertalot G, Di Fiore P, Dietmaier W, Leist M, et al. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun. 2014;5:4839 pubmed publisher
    ..Here we report the identification of a GM130-RasGRF complex as a regulator of Cdc42 at the Golgi...
  35. Brandl K, Tomisato W, Li X, Neppl C, Pirie E, Falk W, et al. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice. Proc Natl Acad Sci U S A. 2012;109:12650-5 pubmed publisher
    ..These studies support a tissue- and organ-specific function for Yipf6 in the maintenance of intestinal homeostasis and implicate the orthologous human gene as a disease susceptibility locus. ..
  36. Wei F, Xiao H, Hu Z, Zhang H, Wang C, Dai H, et al. [Subcellular localization of ataxin-3 and its effect on the morphology of cytoplasmic organoids]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:353-7 pubmed publisher
    ..05). No co-localization was observed for ataxin-3 protein and golgi marker GM130, and mutant ataxin-3 did not cause golgi fragmentation...
  37. Stoetzel C, Bär S, De Craene J, Scheidecker S, Etard C, Chicher J, et al. A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi. Nat Commun. 2016;7:13586 pubmed publisher
    ..Furthermore, we demonstrate its interaction with the golgin GM130 and its localization to the Golgi...
  38. Obata Y, Fukumoto Y, Nakayama Y, Kuga T, Dohmae N, Yamaguchi N. The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J Cell Sci. 2010;123:2649-62 pubmed publisher
    ..These results suggest that initiation of Golgi export of Lyn involves association of ACSL3 with the Lyn C-lobe, which is exposed to the molecular surface in an open conformation. ..
  39. Mazzulli J, Zunke F, Isacson O, Studer L, Krainc D. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proc Natl Acad Sci U S A. 2016;113:1931-6 pubmed publisher
    ..Accumulation of α-syn at the cell body resulted in aberrant association with cis-Golgi-tethering factor GM130 and disrupted the endoplasmic reticulum-Golgi localization of rab1a, a key mediator of vesicular transport...
  40. Fusco C, Micale L, Egorov M, Monti M, D Addetta E, Augello B, et al. The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE. 2012;7:e40440 pubmed publisher
    ..We speculate that when the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation, and promotes their storage in the aggresome for successive clearance...
  41. Giannotta M, Fragassi G, Tamburro A, Vanessa C, Luini A, Sallese M. Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling. Biomed Res Int. 2015;2015:319454 pubmed publisher
    ..of PHB induces intense membrane-trafficking activity at the ER-Golgi interface, as revealed by formation of GM130-positive Golgi tubules, and recruitment of p115, β-COP, and GBF1 to the Golgi complex...
  42. Xie Y, Ma W, Meng J, Ren X. Knockdown of ZFPL1 results in increased autophagy and autophagy‑related cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. Mol Med Rep. 2017;15:2633-2642 pubmed publisher
    ..Zinc finger domain‑FLAG was used to compete with ZFPL1 for golgin A2/GM130 binding...
  43. Kobayashi M, Yamato E, Tanabe K, Tashiro F, Miyazaki S, Miyazaki J. Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line. PLoS ONE. 2016;11:e0151927 pubmed publisher
    ..MIN6c4 cells, and immunostaining analysis indicated that the TMEM59L protein colocalized with insulin and GM130, a Golgi complex marker, in MIN6 cells...
  44. Howe D, Heinzen R. Fractionation of the Coxiella burnetii parasitophorous vacuole. Methods Mol Biol. 2008;445:389-406 pubmed publisher
    ..Conversely, PV preparations are devoid of p62 and GM130, markers of the nucleus and Golgi apparatus, respectively, indicating effective separation of the vacuole from ..
  45. Matsuki T, Matthews R, Cooper J, van der Brug M, Cookson M, Hardy J, et al. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell. 2010;143:826-36 pubmed publisher
    ..signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-Stk25-Golgi matrix protein 130 (GM130) signaling pathway...
  46. Nakamura N. Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions. J Pharmacol Sci. 2010;112:255-64 pubmed
    b>GM130 is a peripheral membrane protein strongly attached to the Golgi membrane and is isolated from the detergent and salt resistant Golgi matrix. GM130 is rich in coiled-coil structures and predicted to take a rod-like shape...
  47. Zhu B, Swärd K, Ekman M, Uvelius B, Rippe C. Cavin-3 (PRKCDBP) deficiency reduces the density of caveolae in smooth muscle. Cell Tissue Res. 2017;368:591-602 pubmed publisher
    ..markers were identical in WT and KO mice, the only exception being a curtailed induction of the Golgi protein GM130. Loss of cavin-3 thus reduces the number of caveolae in smooth muscle and partly destabilizes cavin-1 but the ..
  48. Shen S, Ji Y, Zhang C, Dong S, Yang S, Xiong Z, et al. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018;9:2392 pubmed publisher
    ..Our results suggest that Golgi secretion inhibitors alone or in combination with PI3K/Akt kinase inhibitors may be therapeutically useful for PTEN-deficient cancers. ..
  49. Joachim J, Jefferies H, Razi M, Frith D, Snijders A, Chakravarty P, et al. Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130. Mol Cell. 2015;60:899-913 pubmed publisher
    Starvation-induced autophagy requires activation of the ULK complex at the phagophore. Two Golgi proteins, WAC and GM130, regulate autophagy, however their mechanism of regulation is unknown...
  50. Nishita M, Park S, Nishio T, Kamizaki K, Wang Z, Tamada K, et al. Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness. Sci Rep. 2017;7:1 pubmed publisher
    ..We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and ..
  51. Bayer M, Fischer J, Kremerskothen J, Ossendorf E, Matanis T, Konczal M, et al. Identification and characterization of Iporin as a novel interaction partner for rab1. BMC Cell Biol. 2005;6:15 pubmed
    ..To date p115, GM130, golgin-84 and MICAL have been identified as direct interacting partners...
  52. Rice W, Zhang Y, Chen Y, Matsuzaki T, Brown D, Lu H. Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells. PLoS ONE. 2012;7:e32843 pubmed publisher
    ..Colocalization of AQP2 mutants with several key vesicular markers including clathrin, HSP70/HSC70, EEA, GM130 and Rab11 revealed no major differences...
  53. Liu C, Mei M, Li Q, Roboti P, Pang Q, Ying Z, et al. Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice. Proc Natl Acad Sci U S A. 2017;114:346-351 pubmed publisher
    ..Here we report that targeted loss of the golgin GM130 leads to a profound neurological phenotype in mice...
  54. Katayama K, Kuriki M, Kamiya T, Tochigi Y, Suzuki H. Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis. Biochem Biophys Res Commun. 2018;499:459-465 pubmed publisher
    ..was expressed in normal, but not in ocd/ocd, chondrocytes in the epiphyseal areas of embryonic femurs, whereas GM130 was expressed in both normal and ocd/ocd chondrocytes...
  55. Wang F, Zhang L, Duan X, Zhang G, Wang Z, Wang Q, et al. RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis. Cell Cycle. 2015;14:2835-43 pubmed publisher
    ..Moreover, FMNL1 depletion resulted in aberrant localization and expression patterns of a cis-Golgi marker protein, GM130. Finally, we found that the small GTPase RhoA might be the upstream regulator of FMNL1...
  56. Otahal A, Fuchs R, Al Allaf F, Blaas D. Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. J Virol. 2015;89:11723-6 pubmed publisher
    ..colocalized with LDLR, ER-Golgi intermediate compartment protein 53 (ERGIC53), LAMP2, and vimentin but not with GM130 or calnexin, suggesting that VSVG interacts with LDLR within the ERGIC, resulting in rerouting into the aggresome/..
  57. Uribe M, Haro C, Ventero M, Campello L, Cruces J, Martín Nieto J. Expression pattern in retinal photoreceptors of POMGnT1, a protein involved in muscle-eye-brain disease. Mol Vis. 2016;22:658-73 pubmed
    ..and concentrated in the myoid portion of the photoreceptor inner segments, where the protein colocalized with GM130, a Golgi complex marker. The presence of POMGnT1 in the Golgi complex was also evident in 661W cells...
  58. Mario L, Borghesi J, Crivellari Damasceno W, Favaron P, Carreira A, Will S, et al. Egg and fourth instar larvae gut of Aedes aegypti as a source of stem cells. Tissue Cell. 2016;48:558-65 pubmed publisher
    ..Sox2 and OCT3/4), neural cells (Nestin), mesenchymal cells (Vimentin and Stro-1), and endosomal cells (GM130 and RAB5). In culture, cells from both tissues (eggs and larvae gut) were composed by a heterogeneous population...
  59. Satoh T, Nakamura Y, Satoh A. The roles of Syx5 in Golgi morphology and Rhodopsin transport in Drosophila photoreceptors. Biol Open. 2016;5:1420-1430 pubmed publisher
    ..in Drosophila In wild-type photoreceptors, Syx5 localizes to cis-Golgi, along with cis-Golgi markers: Rab1 and GM130. We observed that Syx5-deficient photoreceptors show notable accumulation of these cis-Golgi markers accompanying ..
  60. Puthenveedu M, Bachert C, Puri S, Lanni F, Linstedt A. GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. Nat Cell Biol. 2006;8:238-48 pubmed
    ..is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65...
  61. Tenorio M, Luchsinger C, Mardones G. Protein kinase A activity is necessary for fission and fusion of Golgi to endoplasmic reticulum retrograde tubules. PLoS ONE. 2015;10:e0135260 pubmed publisher
    ..We found that Golgi-to-ER retrograde transport of the Golgi matrix proteins giantin, GM130, GRASP55, GRASP65, and p115 was impaired in the presence of PKA inhibitors...
  62. Hiyoshi M, Takahashi Makise N, Yoshidomi Y, Chutiwitoonchai N, Chihara T, Okada M, et al. HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src kinase Hck. J Cell Physiol. 2012;227:1090-7 pubmed publisher
    ..of Nef and Hck and the expression of a Golgi-targeted active Hck mutant caused alterations in the distribution of GM130, a Golgi protein that was shown to be required for efficient protein glycosylation...
  63. Ishida R, Yamamoto A, Nakayama K, Sohda M, Misumi Y, Yasunaga T, et al. GM130 is a parallel tetramer with a flexible rod-like structure and N-terminally open (Y-shaped) and closed (I-shaped) conformations. FEBS J. 2015;282:2232-44 pubmed publisher
    b>GM130 is a cytoplasmic peripheral membrane protein localized on the cis side of the Golgi apparatus...
  64. Xu J, Liu F, Li W, Zhao Y, Zhao D, Luo Y, et al. Cylindrical Spirals in Skeletal Muscles Originate From the Longitudinal Sarcoplasmic Reticulum. J Neuropathol Exp Neurol. 2016;75:148-55 pubmed
    ..CSs exhibited no immunoreactivity for the Golgi apparatus marker GM130, the nuclear membrane emerin, desmin, the autophagosome marker LC3, the lysosomal membrane marker LAMP2, ..
  65. Majoul I, Straub M, Hell S, Duden R, Söling H. KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. Dev Cell. 2001;1:139-53 pubmed
    ..Both p24a and p23 interact with ARF1, but only p24 interacts with ARFGAP. These findings suggest a model for how cargo-induced oligomerization of ERD2 regulates its sorting into COPI-coated buds. ..
  66. Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G. Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons. Mol Neurodegener. 2016;11:43 pubmed publisher
    ..of Golgi-derived microtubules, loss of the COPI coat subunit ?-COP, cytoplasmic dispersion of the Golgi tether GM130, strong accumulation of the ER-Golgi v-SNAREs GS15 and GS28 as well as tubular/vesicular Golgi fragmentation...
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    ..The Golga5-deficient mice enable further investigation of the roles and functional specificity of golgins in development and diseases. ..
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    ..We have identified a novel function for the GA protein, GM130, in the regulation of centrosome morphology, position and function during interphase...
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    ..In NRK cells, however, subsets of both TGN38 and golgin-97, but not ManII and GM130, remained associated with the centrosome throughout the cell cycle...
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    ..Intriguingly, mutations in one of the proteins identified, WKL1, have been previously suggested to underlie the aetiology of catatonic schizophrenia. ..
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    ..Collectively, our results reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway. ..
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    ..staining using antibodies against ABCA12, glucosylceramide and two Golgi apparatus markers (TGN46 and GM130) in normal human skin and cultured keratinocytes...
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    ..PRMT5 interacts with the golgin GM130, and depletion of PRMT5 causes defects in Golgi ribbon formation...
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    The cis-Golgi matrix protein GM130 is phosphorylated in mitosis on serine 25. Phosphorylation inhibits binding to p115, a vesicle-tethering protein, and has been implicated as an important step in the mitotic Golgi fragmentation process...
  78. Jesch S. Inheriting a structural scaffold for Golgi biosynthesis. Bioessays. 2002;24:584-7 pubmed
    ..The outcome of this study suggests that a templating mechanism for the formation of Golgi structure may exist. This study has important implications for understanding mechanisms that govern Golgi biogenesis. ..
  79. Derby M, Lieu Z, Brown D, Stow J, Goud B, Gleeson P. The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic. 2007;8:758-73 pubmed
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    ..Mechanisms exist to connect tethering with fusion, but in most cases, the details remain poorly understood. GM130 is a member of the golgin family of coiled-coil proteins tat is involved in membrane tethering at the endoplasmic ..
  81. Cordell P, Kile B, Standeven K, Josefsson E, Pease R, Grant P. Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion. Blood. 2010;115:2674-81 pubmed publisher
    ..adjacent to the plasma membrane, which also contain trans-Golgi network protein-46 and Golgi matrix protein-130 (GM130) but not the endoplasmic reticulum luminal protein, protein disulphide isomerase...
  82. Fidalgo M, Fraile M, Pires A, Force T, Pombo C, Zalvide J. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. J Cell Sci. 2010;123:1274-84 pubmed publisher
    ..on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. Cells depleted of CCM3 show a disassembled Golgi apparatus...
  83. Gosselin P, Martineau Y, Morales J, Czjzek M, Glippa V, Gauffeny I, et al. Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Nucleic Acids Res. 2013;41:7783-92 pubmed publisher
    ..Taken together, our results illustrate that we developed a powerful method for identifying new eIF4E partners and open new perspectives for understanding eIF4E-specific regulation. ..
  84. Wei J, Zhang Z, Wynn R, Seemann J. GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell. 2015;162:287-299 pubmed publisher
    ..Upon mitotic entry, the Golgi matrix protein GM130 interacts with importin α via a classical nuclear localization signal that recruits importin α to ..
  85. Zhao J, Yang C, Guo S, Wu Y. GM130 regulates epithelial-to-mesenchymal transition and invasion of gastric cancer cells via snail. Int J Clin Exp Pathol. 2015;8:10784-91 pubmed
    ..As a cis-Golgi matrix protein, GM130 plays an important role in cell cycle progression and transport of protein in the secretory pathway...
  86. Wallis N, Lau C, Farg M, Atkin J, Beart P, O Shea R. SOD1 Mutations Causing Familial Amyotrophic Lateral Sclerosis Induce Toxicity in Astrocytes: Evidence for Bystander Effects in a Continuum of Astrogliosis. Neurochem Res. 2018;43:166-179 pubmed publisher
    ..A4V SOD1-EGFP altered F-actin and Hoechst staining, indicative of cytoskeletal and nuclear changes, and altered GM130 labelling suggesting fragmentation of Golgi apparatus...
  87. Park S, Kim S, Kim M, Hong Y, Lee A, Lee H, et al. GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver. Biochem Biophys Res Commun. 2018;495:594-600 pubmed publisher
    ..Therefore, we confirmed the associations among Golgi function, fibrosis, and autophagy. Moreover, GOLGA2 knockout mice may be a potentially valuable animal model for studying autophagy-induced fibrosis. ..
  88. Miles S, McManus H, Forsten K, Storrie B. Evidence that the entire Golgi apparatus cycles in interphase HeLa cells: sensitivity of Golgi matrix proteins to an ER exit block. J Cell Biol. 2001;155:543-55 pubmed
    ..Redistribution of GalNAcT2 was more sensitive to low Sar1p(dn) concentrations than giantin or GM130. Redistribution was most rapid for p27, COPI, and p115...
  89. Murwantoko -, Yano M, Ueta Y, Murasaki A, Kanda H, Oka C, et al. Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. Biochem J. 2004;381:895-904 pubmed
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    ..In a subsequent two-hybrid screen using PIGEA-14 as a bait, we found GM130, a component of the cis-compartment of the Golgi apparatus...
  91. Khadka S, Vangeloff A, Zhang C, Siddavatam P, Heaton N, Wang L, et al. A physical interaction network of dengue virus and human proteins. Mol Cell Proteomics. 2011;10:M111.012187 pubmed publisher
    ..This study provides a valuable starting point for additional investigations into the roles of human proteins in DENV infection. ..
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    b>GM130 and GRASP65 are Golgi peripheral membrane proteins that play a key role in Golgi stacking and vesicle tethering. However, the molecular details of their interaction and their structural role as a functional unit remain unclear...