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Genomes and Genes | glutaredoxin 5SummaryGene Symbol: glutaredoxin 5 Description: glutaredoxin 5 Alias: C14orf87, FLB4739, GRX5, PR01238, PRO1238, glutaredoxin 5 homolog, glutaredoxin-related protein 5, mitochondrial, monothiol glutaredoxin-5 Species: human Top Publications
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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblastsHong Ye
Molecular Medicine Program, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 120:1749-61. 2010b>Glutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a zebrafish model and of sideroblastic anemia in a human patient...
Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitroD A Davis
HIV and AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:25935-40. 1997..Our results implicate thioltransferase in the regulation and/or maintenance of protease activity in HIV-1 infected cells...
Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatmentClara Camaschella
Vita Salute University and San Raffaele Scientific Institute, Milan, Italy
Semin Hematol 46:371-7. 2009..The identification of other genes, such as adenosine triphosphate (ATP) binding cassette B7 (ABCB7) and glutaredoxin 5 (GLRX5), has strengthened the role of iron sulfur cluster biogenesis in sideroblast formation and revealed a ..- Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutationsAnke K Bergmann
Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Pediatr Blood Cancer 54:273-8. 2010..enzyme pseudouridine synthase 1 (PUS1), a mitochondrial ATP-binding cassette transporter (ABCB7), glutaredoxin 5 (GLRX5), as well as mitochondrial DNA deletions... - The interaction of mitochondrial iron with manganese superoxide dismutaseAmornrat Naranuntarat
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Biol Chem 284:22633-40. 2009..when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1... - Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5Yi Wang
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:651-3. 2009b>Grx5 from the yeast Saccharomyces cerevisiae is a monothiol glutaredoxin that is involved in iron-sulfur cluster biogenesis. Here, yeast Grx5 was cloned and overproduced in Escherichia coli... - Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stressGabriel R Linares
Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, CA 92357, USA
Bone 44:795-804. 2009..Osteoblasts were transfected with Grx5 siRNA and treated with hydrogen peroxide (H(2)O(2))... - Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processesE V Kalinina
Center for Theoretical Problems of Physico Chemical Pharmacology, Russian Academy of Sciences, Moscow, 119991, Russia
Biochemistry (Mosc) 73:1493-510. 2008..Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups .. - Recent advances in the understanding of inherited sideroblastic anaemiaClara Camaschella
Vita Salute San Raffaele University and San Raffaele Scientific Institute, Milan, Italy
Br J Haematol 143:27-38. 2008..Local mitochondrial iron overload is present in all sideroblastic anaemias, whereas systemic iron overload occurs only in the forms because of primary or secondary deficiency of ALAS2... - A role for yeast glutaredoxin genes in selenite-mediated oxidative stressAnna Lewinska
Department of Biochemistry and Cell Biology, University of Rzeszow, Cegielniana 12, PL 35 959 Rzeszow, Poland
Fungal Genet Biol 45:1182-7. 2008..this phenomenon and establish the roles of other components of yeast glutaredoxin system, in particular glutaredoxin 5 in the selenite resistance... - Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clustersSibali Bandyopadhyay
Department of Chemistry, Centre for Metalloenzyme Studies, University of Georgia, Athens, GA, USA
EMBO J 27:1122-33. 2008..These Grxs possess the same monothiol CGFS active site as yeast Grx5 and both were able to complement a yeast grx5 mutant defective in Fe-S cluster assembly... - Oxidative stress responses and lipid peroxidation damage are induced during dehydration in the production of dry active wine yeastsElena Garre
Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, Valencia, Spain
Int J Food Microbiol 136:295-303. 2010..The main gene expression response involves the induction of genes TRR1 and GRX5, corresponding to the two main redox balance systems, thioredoxins and glutathione/glutaredoxins... - Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeastKyoung Dong Kim
Institute of Microbiology, Seoul National University, Seoul 151 742, South Korea
Biochem Biophys Res Commun 392:467-72. 2010..Among three monothiol glutaredoxins (Grx3, 4, and 5) in Schizosaccharomyces pombe only Grx5 resides in mitochondria... - Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeastKyoung Dong Kim
Laboratory of Molecular Microbiology, School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, Republic of Korea
Biochem Biophys Res Commun 408:609-14. 2011The fission yeast Schizosaccharomyces pombe contains two CGFS-type monothiol glutaredoxins, Grx4 and Grx5, which are localized primarily in the nucleus and mitochondria, respectively... - Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4Yujeong Kim
Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501 190, Republic of Korea
Biochem Biophys Res Commun 407:175-80. 2011..Reduction of hPTEN was delayed in each of S. cerevisiae grx5Δ and ycp4Δ mutants... - New mutation in erythroid-specific delta-aminolevulinate synthase as the cause of X-linked sideroblastic anemia responsive to pyridoxineJana Kucerova
Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
Acta Haematol 125:193-7. 2011..In addition, autosomal recessive mutations in the erythroid-specific mitochondrial transporter SLC25A38 and glutaredoxin 5 (GLRX5) have recently been identified in SA patients with isolated erythroid phenotype. - Structural and functional diversity of glutaredoxins in yeastEnrique Herrero
Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
Curr Protein Pept Sci 11:659-68. 2010..subfamily in Saccharomyces cerevisiae participate in the synthesis of the iron-sulfur clusters in mitochondria (Grx5), or in signalling the iron status inside the cell for regulation of iron uptake and intracellular iron .. - The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activityCatrine Johansson
University of Oxford, UK
Biochem J 433:303-11. 2011Human GLRX5 (glutaredoxin 5) is an evolutionarily conserved thiol-disulfide oxidoreductase that has a direct role in the maintenance of normal cytosolic and mitochondrial iron homoeostasis, and its expression affects haem biosynthesis and .. - Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genesAyse Banu Demir
Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey
Biochem Biophys Res Commun 400:106-10. 2010..aged mutants lacking the mitochondrial antioxidant genes: GRX2, CCP1, SOD1, GLO4, TRR2, TRX3, CCS1, SOD2, GRX5, and PRX1... - Human iron-sulfur cluster assembly, cellular iron homeostasis, and diseaseHong Ye
Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Biochemistry 49:4945-56. 2010..However, the human diseases, Friedreich ataxia, glutaredoxin 5-deficient sideroblastic anemia, ISCU myopathy, and ABCB7 sideroblastic anemia/ataxia syndrome, affect specific .. - Inhibition of electron transport chain assembly and function promotes photodynamic killing of CandidaYeissa Chabrier-Roselló
Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
J Photochem Photobiol B 99:117-25. 2010..A S. cerevisiae mitochondrial glutaredoxin grx5 mutant, defective in assembly of Fe-S clusters critical for Complex III function, displayed increased sensitivity .. - AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stressNing Hui Cheng
Plant Physiology Group, USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA
FEBS Lett 582:848-54. 2008..monothiol glutaredoxin (Grx), AtGRX4, was targeted to chloroplasts/plastids and had high similarity to yeast Grx5. In yeast expression assays, AtGRX4 localized to the mitochondria and suppressed the sensitivity of grx5 cells to .. - Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1Michael Filser
Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
Biol Chem 389:21-32. 2008..Expression of 1-C-Grx1 in Grx5-deficient yeast cells with its authentic presequence targeted the protein to the mitochondria and partially .. - Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesisRebecca A Wingert
Stem Cell Program and Division Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 436:1035-39. 2005..Here we show that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly... - A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductaseAristi Potamitou Fernandes
Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Biol Chem 280:24544-52. 2005..potential active site and shows high sequence homology to the other monothiol glutaredoxins and especially to yeast Grx5. Experiments with gene knock-out techniques showed that the reading frame encoding Grx4 was essential... - Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombeWoo Hyun Chung
Laboratory of Molecular Microbiology, School of Biological Sciences, Institute of Microbiology, Seoul National University, Seoul 151 742, Republic of Korea
Biochem Biophys Res Commun 330:604-10. 2005..revealed that Grx3 is targeted to nuclear rim and endoplasmic reticulum, Grx4 primarily to the nucleus, and Grx5 to mitochondria... - Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxinsMaría Micaela Molina
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
J Biol Chem 279:51923-30. 2004..In Saccharomyces cerevisiae, Grx1 and Grx2 are cytosolic dithiol glutaredoxins, whereas Grx3, Grx4, and Grx5 are monothiol glutaredoxins... - Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism. II. Role of glutaredoxin Grx5Rui Alves
Departament de Ciencies Mediques Basiques, Universidad de Lleida, Lleida, Spain
Proteins 57:481-92. 2004b>Grx5 is a Saccharomyces cerevisiae glutaredoxin involved in iron-sulfur cluster (FeSC) biogenesis... - Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genesGemma Belli
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
J Biol Chem 279:12386-95. 2004The Saccharomyces cerevisiae GRX5 gene codes for a mitochondrial glutaredoxin involved in the synthesis of iron/sulfur clusters... - Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxinJordi Tamarit
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
J Biol Chem 278:25745-51. 2003b>Grx5 is a yeast mitochondrial protein involved in iron-sulfur biogenesis that belongs to a recently described family of monothiolic glutaredoxin-like proteins. No member of this family has been biochemically characterized previously... - Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymesMaria Teresa Rodriguez-Manzaneque
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Spain
Mol Biol Cell 13:1109-21. 2002Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants... - The fission yeast gene encoding monothiol glutaredoxin 5 is regulated by nitrosative and osmotic stressesHong Gyum Kim
Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Korea
Mol Cells 20:43-50. 2005..We have cloned the monothiol Grx5 gene from the genomic DNA of the fission yeast Schizosaccharomyces pombe... - Characterization and regulation of the gene encoding monothiol glutaredoxin 3 in the fission yeast Schizosaccharomyces pombeJeong Su Moon
Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Korea
Mol Cells 20:74-82. 2005..3 kDa. The putative protein has 27% homology with Grx5, and contains many hydrophobic amino acid residues in its N-terminal region. S... - Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondriaMaria Micaela Molina-Navarro
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
FEBS Lett 580:2273-80. 2006The Saccharomyces cerevisiae monothiol glutaredoxin Grx5 participates in the mitochondrial biogenesis of iron-sulfur clusters. Grx5 homologues exist in organisms from bacteria to humans... - Redox properties and evolution of human glutaredoxinsJohan Sagemark
School of Life Sciences, Södertörns högskola, S 141 89 Huddinge, Sweden
Proteins 68:879-92. 2007..Three distinct groups were found: Grx1, Grx2, and Grx5, the latter representing a highly conserved group of monothiol glutaredoxins having a C-G-F-S active site sequence, .. - The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overloadClara Camaschella
Vita Salute University, Milan, Italy
Blood 110:1353-8. 2007..The zebrafish mutant shiraz has severe anemia and is embryonically lethal because of glutaredoxin 5 (GRLX5) deletion, insufficient biogenesis of mitochondrial iron-sulfur (Fe/S) clusters, and deregulated iron-.. - Effects of deleting mitochondrial antioxidant genes on life spanErcan Selcuk Unlu
Department of Biology, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey
Ann N Y Acad Sci 1100:505-9. 2007..it was found that among the known mitochondrial antioxidant genes (TTR1, CCD1, SOD1, GLO4, TRR2, TRX3, CCS1, SOD2, GRX5, PRX1), deletion of only three genes, SOD1 (Cu, Zn superoxide dismutase), SOD2 (Manganese-containing superoxide .. - Monothiol glutaredoxins: a common domain for multiple functionsE Herrero
Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, Lleida, Spain
Cell Mol Life Sci 64:1518-30. 2007..Studies in Saccharomyces cerevisiae have demonstrated the role of the Grx5 protein in the biogenesis of iron-sulfur clusters... - In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiaeRui Alves
Departament de Ciencies Mediques Basiques, Universidad de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
BMC Syst Biol 1:10. 2007..One such class of pathways is involved in the biogenesis of Iron-Sulfur Clusters (ISC)... - Glutaredoxins in fungiEnrique Herrero
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008, Lleida, Spain
Photosynth Res 89:127-40. 2006..The function of yeast Grx5 seems to be conserved along the evolutionary scale. - AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damageNing Hui Cheng
Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 281:26280-8. 2006..demonstrate that a plant protein, AtGRXcp, is a chloroplast-localized monothiol Grx with high similarity to yeast Grx5. In yeast expression assays, AtGRXcp localized to the mitochondria and suppressed the sensitivity of yeast grx5 .. - Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferasesAna Garcera
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
Biochem J 398:187-96. 2006..Replacing the active site of the yeast monothiol glutaredoxin Grx5 with the proposed Gto2 active site containing Cys46 allows Grx5 to retain some activity against HED... - Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiaeM T Rodríguez-Manzaneque
Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Spain
Mol Cell Biol 19:8180-90. 1999..In this work, another subfamily of yeast glutaredoxins (Grx3, Grx4, and Grx5) that differs from the first in containing a single cysteine residue at the putative active site is described...