glutamyl transpeptidase

Summary

Gene Symbol: glutamyl transpeptidase
Description: gamma-glutamyltransferase 1
Alias: CD224, D22S672, D22S732, GGT, GGT 1, GTG, glutathione hydrolase 1 proenzyme, gamma-glutamyltranspeptidase 1, glutathione hydrolase 1, leukotriene-C4 hydrolase, testicular tissue protein Li 73
Species: human
Products:     glutamyl transpeptidase

Top Publications

  1. Li M, Campbell S, McDermott R. gamma-Glutamyltransferase, obesity, physical activity, and the metabolic syndrome in indigenous Australian adults. Obesity (Silver Spring). 2009;17:809-13 pubmed publisher
    ..the association between obesity, metabolic syndrome, physical activity, and elevated gamma-glutamyltransferase (GGT) among Indigenous Australian adults who did not drink alcohol...
  2. Franzini M, Corti A, Fornaciari I, Balderi M, Torracca F, Lorenzini E, et al. Cultured human cells release soluble gamma-glutamyltransferase complexes corresponding to the plasma b-GGT. Biomarkers. 2009;14:486-92 pubmed publisher
    Serum gamma-glutamyltransferase (GGT) is thought to derive from the liver, but its values predict morbidity and mortality for several diseases, such as cardiac infarction, stroke, diabetes, renal failure and cancer...
  3. Irie M, Sohda T, Iwata K, Kunimoto H, Fukunaga A, Kuno S, et al. Levels of the oxidative stress marker ?-glutamyltranspeptidase at different stages of nonalcoholic fatty liver disease. J Int Med Res. 2012;40:924-33 pubmed
    ..oxidative stress in the liver, by determining hepatic expression and serum levels of ?-glutamyltranspeptidase (GGT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in different stages of nonalcoholic fatty liver disease (NAFLD), and ..
  4. Nichols T, Guthridge J, Karp D, Molina H, Fletcher D, Holers V. Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes. Eur J Immunol. 1998;28:4123-9 pubmed
    ..One inhibitory mAb (3A8) was found to recognize the ecto-enzyme gamma-glutamyl transpeptidase (GGT), a membrane protein involved in recycling extracellular glutathione and regulating intracellular ..
  5. Lee D, Jacobs D. Association between serum gamma-glutamyltransferase and C-reactive protein. Atherosclerosis. 2005;178:327-30 pubmed
    A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress...
  6. Yuan X, Waterworth D, Perry J, Lim N, Song K, Chambers J, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet. 2008;83:520-8 pubmed publisher
    ..on chromosome 10 and PNPLA3-SAMM50 on chromosome 22), one locus influencing gamma-glutamyl transferase (GGT) levels (HNF1A on chromosome 12), and three loci for alkaline phosphatase (ALP) levels (ALPL on chromosome 1, GPLD1 ..
  7. Celik T, Yuksel U, Kilic S, Yaman H, Iyisoy A, Karaeren H. The relationship of gamma-glutamyltransferase to aortic elastic properties in young patients with prehypertension. Clin Exp Hypertens. 2010;32:377-84 pubmed publisher
    Some cross-sectional studies have demonstrated a positive association between serum gamma-glutamyltransferase (GGT) levels and blood pressure...
  8. Jung C, Yu J, Bae S, Koh E, Kim M, Park J, et al. Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals. Clin Endocrinol (Oxf). 2011;75:328-34 pubmed publisher
    Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease...
  9. Middelberg R, Benyamin B, de Moor M, Warrington N, Gordon S, Henders A, et al. Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations. Hum Mol Genet. 2012;21:446-55 pubmed publisher
    Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers...

More Information

Publications121 found, 100 shown here

  1. Lee D, Evans J, Robins S, Wilson P, Albano I, Fox C, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2007;27:127-33 pubmed
    To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP)...
  2. Kawamoto R, Kohara K, Tabara Y, Kusunoki T, Otsuka N, Miki T. Association between serum gamma-glutamyl transferase level and prehypertension among community-dwelling men. Tohoku J Exp Med. 2008;216:213-21 pubmed
    Serum gamma-glutamyl transferase (GGT) activity is a general clinical marker of excessive alcohol consumption, and GGT reflects changes in oxidative stress and implicated in the progression of hypertension...
  3. Song S, Kwak I, Kim Y, Kim S, Lee S, Lee D, et al. Can gamma-glutamyltransferase be an additional marker of arterial stiffness?. Circ J. 2007;71:1715-20 pubmed
    It has been recently suggested that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular mortality and atherosclerosis, so the present study evaluated whether GGT is an additional marker of arterial stiffness, ..
  4. Strasak A, Rapp K, Brant L, Hilbe W, Gregory M, Oberaigner W, et al. Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study. Cancer Res. 2008;68:3970-7 pubmed publisher
    Although several epidemiologic studies have shown that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular disease and all-cause mortality, its relationship with cancer incidence remains widely unexplored...
  5. Breitling L, Grandi N, Hahmann H, Wüsten B, Rothenbacher D, Brenner H. Gamma-glutamyltransferase and prognosis in patients with stable coronary heart disease followed over 8 years. Atherosclerosis. 2010;210:649-55 pubmed publisher
    ..The association appeared similar to that reported for primary cardiovascular disease, which should motivate additional studies of its clinical utility in cardiovascular patient care. ..
  6. Kozakova M, Palombo C, Eng M, Dekker J, Flyvbjerg A, Mitrakou A, et al. Fatty liver index, gamma-glutamyltransferase, and early carotid plaques. Hepatology. 2012;55:1406-15 pubmed publisher
    ..and FH-CVD, higher blood pressure, plasma low-density lipoprotein cholesterol, glucose, gamma-glutamyltransferase (GGT), and hsCRP, as compared to subjects without plaques (P < 0.05)...
  7. Zhu C, Xiong Z, Zheng Z, Chen Y, Qian X, Chen X. Association of serum gamma-glutamyltransferase with arterial stiffness in established coronary artery disease. Angiology. 2013;64:15-20 pubmed publisher
    Serum gamma-glutamyltransferase (GGT) has been reported to predict vascular risk. We enrolled 978 patients (507 men and 471 women) with established coronary artery disease (CAD)...
  8. Petta S, Macaluso F, Barcellona M, Cammà C, Cabibi D, Di Marco V, et al. Serum ?-glutamyl transferase levels, insulin resistance and liver fibrosis in patients with chronic liver diseases. PLoS ONE. 2012;7:e51165 pubmed publisher
    ..These data could be useful for the clinical and pharmacologic management of patients with CLD. ..
  9. Sakugawa H, Nakayoshi T, Kobashigawa K, Nakasone H, Kawakami Y, Yamashiro T, et al. Metabolic syndrome is directly associated with gamma glutamyl transpeptidase elevation in Japanese women. World J Gastroenterol. 2004;10:1052-5 pubmed
    ..whether metabolic syndrome is directly or indirectly, through fatty liver, associated with elevated gamma-glutamyl transpeptidase (GGT) levels in Japanese women...
  10. Aragón Herrera A, Feijóo Bandín S, Abella V, Alvarez L, Roselló Lletí E, Portolés M, et al. Serelaxin (recombinant human relaxin-2) treatment affects the endogenous synthesis of long chain poly-unsaturated fatty acids and induces substantial alterations of lipidome and metabolome profiles in rat cardiac tissue. Pharmacol Res. 2019;144:51-65 pubmed publisher
    ..LDL), triglycerides and the hepatic enzymes glutamic-pyruvic transaminase (GTP) and gamma-glutamyltransferase (GGT) levels were analyzed...
  11. Yan J, Ai G, Zhang X, Xu H, Huang Z. Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats. J Ethnopharmacol. 2015;172:202-13 pubmed publisher
    ..Meanwhile, the serum levels of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), and total bile acid (TBA) were used as indices of biliary cell ..
  12. Sobeh M, Mahmoud M, Abdelfattah M, Cheng H, El Shazly A, Wink M. A proanthocyanidin-rich extract from Cassia abbreviata exhibits antioxidant and hepatoprotective activities in vivo. J Ethnopharmacol. 2018;213:38-47 pubmed publisher
    ..the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT), in addition to liver peroxidation product malondialdehyde (MDA) and glutathione content (GSH), as well as albumin ..
  13. Dain A, Repossi G, Diaz Gerevini G, Vanamala J, Das U, Eynard A. Long chain polyunsaturated fatty acids (LCPUFAs) and nordihydroguaiaretic acid (NDGA) modulate metabolic and inflammatory markers in a spontaneous type 2 diabetes mellitus model (Stillman Salgado rats). Lipids Health Dis. 2016;15:205 pubmed
    ..TGs), total plasma fatty acids (FA), A1C hemoglobin (HbA1C), C-reactive protein (CRP), gamma glutamyl transpeptidase (GGT), lipo and hydro peroxides, nitrites and IL-6 (in plasma and liver, kidney, and pancreas) and ..
  14. Bakr R, El Naa M, Zaghloul S, Omar M. Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity. BMC Complement Altern Med. 2017;17:52 pubmed publisher
    ..aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT) and total bilirubin were performed...
  15. Eslami L, Merat S, Malekzadeh R, Nasseri Moghaddam S, Aramin H. Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Cochrane Database Syst Rev. 2013;:CD008623 pubmed publisher
    ..regarding the week 54 mean activity levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase...
  16. Pinon M, Carboni M, Colavito D, Cisarò F, Peruzzi L, Pizzol A, et al. Not only Alagille syndrome. Syndromic paucity of interlobular bile ducts secondary to HNF1β deficiency: a case report and literature review. Ital J Pediatr. 2019;45:27 pubmed publisher
    ..A 5-week-old boy was admitted to our department for cholestatic jaundice with increased gamma-glutamyl transpeptidase and an unremarkable clinical examination...
  17. Helmersson Karlqvist J, Ridefelt P, Lind L, Larsson A. Reference values for 34 frequently used laboratory tests in 80-year-old men and women. Maturitas. 2016;92:97-101 pubmed publisher
    ..creatinine estimated GFR, C-reactive protein, cystatin C, cystatin C estimated GFR, gamma-glutamyltransferase (GGT), iron, iron saturation, lactate dehydrogenase (LDH), magnesium, phosphate, transferrin, triglycerides, urate, urea,..
  18. Ben Slama Ben Salem R, Ktari N, Bkhairia I, Nasri R, Mora L, Kallel R, et al. In vitro and in vivo anti-diabetic and anti-hyperlipidemic effects of protein hydrolysates from Octopus vulgaris in alloxanic rats. Food Res Int. 2018;106:952-963 pubmed publisher
    ..in the activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase as well as in the level of plasma bilirubin on diabetic status was observed, indicating considerable ..
  19. Jagadisan B, Srivastava A. Child with Jaundice and Pruritus: How to Evaluate?. Indian J Pediatr. 2016;83:1311-1320 pubmed
    ..early etiological diagnosis by careful clinical evaluation combined with investigations including gamma glutamyl transpeptidase, radiological imaging (ultrasonography, magnetic resonance cholangiopancreatography), liver biopsy and ..
  20. Feng G, He N, Zhou Y, Li X, Niu C, Liu M, et al. A simpler diagnostic formula for screening nonalcoholic fatty liver disease. Clin Biochem. 2019;64:18-23 pubmed publisher
    ..height and mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase, blood urea nitrogen and blood uric acid (UA), serum creatinine, plasma total cholesterol, triglyceride, ..
  21. Baumgart D, Lowder J, Targan S, Sandborn W, Frankel M. Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease. Am J Gastroenterol. 2009;104:868-76 pubmed publisher
    ..Serum hepatic tests including bilirubin, alkaline phosphatase (AP), gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), visilizumab concentrations, and a panel of ..
  22. Fan P, Zhang D, Halladay J, Driscoll J, Khojasteh S. Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase. Drug Metab Dispos. 2016;44:1253-61 pubmed publisher
    ..Gamma-glutamyl transpeptidase is involved in the initial hydrolysis of glutathione metabolites, leading to formation of proximate ..
  23. Li H, Liu J, Deng M, Guo L, Cheng Y, Song Y. [Clinical and genetic study of an infant with Alagille syndrome: identification of a novel chromosomal interstitial deletion including JAG1 gene]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:1098-1103 pubmed
    ..with markedly elevated bilirubin (predominantly direct bilirubin), total bile acids (TBA) and gamma-glutamyl transpeptidase (GGT). Atrial septal defect and pulmonary stenosis were detected on echocardiography...
  24. Magno S, Ceccarini G, Pelosini C, Jaccheri R, Vitti J, Fierabracci P, et al. LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia. Lipids Health Dis. 2018;17:124 pubmed publisher
    ..ClinicalTrials.gov ID: NCT03425630 . ..
  25. Khan R, Khan M, Sahreen S. CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complement Altern Med. 2012;12:178 pubmed publisher
    ..of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (γ-GT) in serum as was raised by the induction of CCl₄...
  26. Kołodziejski P, Pruszyńska Oszmałek E, Strowski M, Nowak K. Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function. Endocrine. 2017;56:538-550 pubmed publisher
    ..accompanied by reduction of increased alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transpeptidase in T2DM mice with type 2 diabetes mellitus...
  27. Bouhafs L, Moudilou E, Exbrayat J, Lahouel M, Idoui T. Protective effects of probiotic Lactobacillus plantarum BJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats. Ren Fail. 2015;37:1370-8 pubmed publisher
    ..alanine-amino transferase (ALAT), aspartate-amino transferase (ASAT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), urea and creatinine in serum, while urinary urea and creatinine were lower than those of the ..
  28. Malnick S, Maor Y, Melzer E, Ziv Sokolowskaia N, Neuman M. Severe hepatocytotoxicity linked to denosumab. Eur Rev Med Pharmacol Sci. 2017;21:78-85 pubmed
    ..Transaminases reached more than 50 x ULN, and gamma-glutamyl-transpeptidase (GGT) increased to more than 30 x ULN. Serum bilirubin reached 13.8 mg/dL. The serum albumin level decreased to 2.8 g/L...
  29. Sobeh M, Mahmoud M, Abdelfattah M, El Beshbishy H, El Shazly A, Wink M. Hepatoprotective and hypoglycemic effects of a tannin rich extract from Ximenia americana var. caffra root. Phytomedicine. 2017;33:36-42 pubmed publisher
    ..the liver markers alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT), liver peroxidation product malondialdehyde (MDA), glutathione content (GSH), albumin and total bilirubin ..
  30. Bharani V, Ramesh V, Rao R, Tewari S. Evaluation of gamma glutamyl transferase as a marker of cardiovascular risk, in 200 angiographically proven coronary artery disease patients. Indian Heart J. 2017;69:325-327 pubmed publisher
    Gamma glutamyl transferase (GGT) is emerging as a promising marker for assessing cardiovascular risk...
  31. Huang H, Wang X, Li X, Chen H, Zheng X, Lin J, et al. Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma. BMC Cancer. 2017;17:544 pubmed publisher
    ..the preoperative alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in ESCC patients...
  32. Kotronen A, Laaksonen M, Heliövaara M, Reunanen A, Tuomilehto J, Yki Järvinen H, et al. Fatty liver score and 15-year incidence of type 2 diabetes. Hepatol Int. 2013;7:610-21 pubmed publisher
    ..were determined from serum samples, and the FL score was formed using BMI, fasting glucose, HDL cholesterol, and GGT concentrations...
  33. Qiu Y, Gong J, Feng J, Wang R, Han J, Liu T, et al. Defects in myosin VB are associated with a spectrum of previously undiagnosed low ?-glutamyltransferase cholestasis. Hepatology. 2017;65:1655-1669 pubmed publisher
    Hereditary cholestasis in childhood and infancy with normal serum gamma-glutamyltransferase (GGT) activity is linked to several genes. Many patients, however, remain genetically undiagnosed...
  34. Kawakami H, Tanizaki J, Tanaka K, Haratani K, Hayashi H, Takeda M, et al. Imaging and clinicopathological features of nivolumab-related cholangitis in patients with non-small cell lung cancer. Invest New Drugs. 2017;35:529-536 pubmed publisher
    ..bile duct wall; (3) a dominant increase in the biliary tract enzymes alkaline phosphatase and gamma-glutamyl transpeptidase relative to the hepatic enzymes aspartate and alanine aminotransferase; (4) normal or reduced levels of ..
  35. Kunutsor S, Khan H, Laukkanen J. γ-Glutamyltransferase and Risk of Sudden Cardiac Death in Middle-Aged Finnish Men: A New Prospective Cohort Study. J Am Heart Assoc. 2016;5: pubmed publisher
    Glutamyltransferase (GGT) has been linked to an increased risk of several cardiovascular outcomes; however, the relationship of GGT with sudden cardiac death (SCD) has not been investigated previously...
  36. Yang Y, Yuan J, Yao X, Zhang R, Yang H, Zhao R, et al. BMPR1B mutation causes Pierre Robin sequence. Oncotarget. 2017;8:25864-25871 pubmed publisher
    ..b>GTG banding, comparative genomic hybridization, whole-genome sequencing, and Sanger sequencing were performed to ..
  37. Abdullah M, Abed M, Richardson A. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Sci Rep. 2017;7:8090 pubmed publisher
    ..Pitavastatin reduced levels of GGT-IIβ and the membrane localization of several small GTPases and this was potentiated by zoledronic acid...
  38. Lin Y, Gao Y, Ma Z, Jiang T, Zhou X, Li Z, et al. Bioluminescence probe for ?-glutamyl transpeptidase detection in vivo. Bioorg Med Chem. 2018;26:134-140 pubmed publisher
    To detect ?-Glutamyl Transpeptidase (GGT) activity in vitro and in vivo, a bioluminescence probe with high sensitivity and specificity was well designed and synthesized...
  39. Laperche Y, Bulle F, Aissani T, Chobert M, Aggerbeck M, Hanoune J, et al. Molecular cloning and nucleotide sequence of rat kidney gamma-glutamyl transpeptidase cDNA. Proc Natl Acad Sci U S A. 1986;83:937-41 pubmed
    ..of 14-base DNA oligomers containing all 32 possible sequences coding for residues 32-36 of the gamma-glutamyl transpeptidase (EC 2.3.2.2.) heavy chain...
  40. Liu C, Li K, Wang Q, Wang F, Zeng W, Mai X, et al. The complete mitochondrial genome of jade perch, Scortum barcoo (Perciformes: Terapontidae: Scortum). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3346-7 pubmed publisher
    ..13%. All protein-coding genes are initiated with ATG except for COX1, which begin with GTG instead. Meanwhile, the termination codons of 13 protein-coding genes are varied with TAA, TAG, TA, T or AGG...
  41. Abo El Noor M, Elhosary N, Elatrozy H, Abou Elgheit H, Elbelkasy A, Fath A, et al. Forensic and clinical significance of serum amylase, lipase and gamma glutamyl transferase as predictors of outcome in head injured patients. J Forensic Leg Med. 2017;52:229-235 pubmed publisher
    ..was to investigate the forensic and clinical significance of serum amylase, lipase and gamma glutamyl transferase (GGT) as predictors of the outcome in head injured patients...
  42. Dong Z, Zou J, Sun D, Shi G, Ke A, Cai J, et al. Preoperative Albumin-Bilirubin Score for Postoperative Solitary Hepatocellular Carcinoma within the Milan Criteria and Child-Pugh A Cirrhosis. J Cancer. 2017;8:3862-3867 pubmed publisher
    ..Furthermore, the ALBI score was significantly related to the degree of liver cirrhosis and serum ?-glutamyl transpeptidase (GGT) concentration in solitary HCC cases within the Milan criteria and C-P A cirrhosis...
  43. Gondim P, Rosa P, Okamura D, Silva V, Andrade E, Biihrer D, et al. Benefits of Fish Oil Consumption over Other Sources of Lipids on Metabolic Parameters in Obese Rats. Nutrients. 2018;10: pubmed publisher
    ..fat content, blood glucose levels, as well as alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) decreased in FO groups (p < 0.05)...
  44. Li B, Yao Y, Li D, Ni Q, Zhang M, Xie M, et al. The complete mitochondrial genome sequence of White-collared Yuhina (Yuhina diademata). Mitochondrial DNA A DNA Mapp Seq Anal. 2017;28:21-22 pubmed publisher
    ..Most PCGs began with ATG, while COI and ND2 genes started with GTG. Nine of the PCGs used complete (TAA) or incomplete (TA- or T--) stop codon, while ND1 and ND6 genes ended with AGA,..
  45. Zhou Y, Zheng J, Liu W, Miele L, Vitale A, Van Poucke S, et al. The NAFL Risk Score: A simple scoring model to predict 4-y risk for non-alcoholic fatty liver. Clin Chim Acta. 2017;468:17-24 pubmed publisher
    ..The NAFL Risk Score was developed as 0 to 18 points comprising of BMI, TG×GGT, ALT/AST, LDL-C/HDL-C and UA in both sexes...
  46. Ogihara T, Arakawa H, Jomura T, Idota Y, Koyama S, Yano K, et al. Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity. J Toxicol Sci. 2017;42:499-507 pubmed publisher
    ..aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and ?-glutamyl transpeptidase (?-GTP), were measured...
  47. Guo H, Ding E, Bai Y, Zhang H, Shen H, Wang J, et al. Association of genetic variations in FOXO3 gene with susceptibility to noise induced hearing loss in a Chinese population. PLoS ONE. 2017;12:e0189186 pubmed publisher
    ..43, 1.43, and 1.31 respectively) and the haplotype GAC and others (TGT/GGT/GGC/GAT) (rs2802292-rs10457180-rs12206094) (OR = 1.49 and 2...
  48. Tong Q, Chen B, Zhang R, Zuo C. Standardization of clinical enzyme analysis using frozen human serum pools with values assigned by the International Federation of Clinical Chemistry and Laboratory Medicine reference measurement procedures. Scand J Clin Lab Invest. 2017;:1-7 pubmed publisher
    ..assigned values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), creatine kinase (CK) and lactate dehydrogenase (LDH) by six laboratories with established International ..
  49. Gupta S, Rajvanshi P, Malhi H, Slehria S, Sokhi R, Vasa S, et al. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver. Am J Physiol Gastrointest Liver Physiol. 2000;279:G815-26 pubmed
    ..Moreover, host hepatocytes expressed gamma-glutamyl transpeptidase (GGT) extensively, which was observed even 2 years after cell transplantation...
  50. Choi S, Oh D, Kwon K, Lee J, Koh M, Lee J, et al. A vegetarian diet does not protect against nonalcoholic fatty liver disease (NAFLD): A cross-sectional study between Buddhist priests and the general population. Turk J Gastroenterol. 2015;26:336-43 pubmed publisher
    ..waist circumference, metabolic syndrome, high albumin, high glucose, high AST, high ALT, high gamma glutamyl transpeptidase (GGT), high triglycerides, low HDL, high low density lipoprotein (LDL), and high total cholesterol...
  51. Gianturco V, Troisi G, Bellomo A, Bernardini S, D Ottavio E, Formosa V, et al. Impact of combined therapy with alpha-lipoic and ursodeoxycolic acid on nonalcoholic fatty liver disease: double-blind, randomized clinical trial of efficacy and safety. Hepatol Int. 2013;7:570-6 pubmed publisher
    ..Serum concentration of gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin and platelets (PLT) were ..
  52. Yang M, Fan J, Wang J, Zhao Y, Teng Y, Liu P. Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease. Immunol Res. 2016;64:610-8 pubmed publisher
    ..In addition, a haplotype block across CFB (GTG) was significantly predisposed to uveitis with protective effect (OR 0.66, P corr = 0.048)...
  53. Choi H, Kim K, Rhee Y, Lim S. Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption. Endocrinol Metab (Seoul). 2016;31:64-71 pubmed publisher
    Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases...
  54. Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka M, et al. Novel round cells in urine sediment and their clinical implications. Clin Chim Acta. 2016;457:142-9 pubmed publisher
    ..A prospective analysis revealed that patients who had more round cells were more likely to require hemodialysis within a year. Round cells are a novel marker that can be used to predict the need for hemodialysis. ..
  55. Ueo H, Shinden Y, Tobo T, Gamachi A, Udo M, Komatsu H, et al. Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green. Sci Rep. 2015;5:12080 pubmed publisher
    ..gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that the enzyme γ-glutamyltranspeptidase (GGT) is overexpressed on membranes of various cancer cells, but is not expressed in normal tissue...
  56. Kawakubo K, Ohnishi S, Hatanaka Y, Hatanaka K, Hosono H, Kubota Y, et al. Feasibility of Using an Enzymatically Activatable Fluorescence Probe for the Rapid Evaluation of Pancreatic Tissue Obtained Using Endoscopic Ultrasound-Guided Fine Needle Aspiration: a Pilot Study. Mol Imaging Biol. 2016;18:463-71 pubmed publisher
    ..activatable probe onto the EUS-FNA samples; the probe fluoresces in the presence of γ-glutamyltranspeptidase (GGT). We evaluated GGT expression in pancreatic cancer cell lines in vitro...
  57. Zhang J, Quan C, Wang C, Wu H, Li Z, Ye Q. Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production. Microb Cell Fact. 2016;15:38 pubmed publisher
    ..included disrupting the precursor degradation pathways (tnaA and sdaA), eliminating L-glutathione degradation (ggt and pepT), and manipulating the intracellular ATP level (disruption of glgB)...
  58. Kowalska K, Milnerowicz H. The Influence of Age and Gender on the Pro/Antioxidant Status in Young Healthy People. Ann Clin Lab Sci. 2016;46:480-8 pubmed
    ..The similar levels of malondialdehyde concentrations and gamma-glutamyl transpeptidase activities were observed in all groups...
  59. Turki R, Assidi M, Banni H, Zahed H, Karim S, Schulten H, et al. Associations of recurrent miscarriages with chromosomal abnormalities, thrombophilia allelic polymorphisms and/or consanguinity in Saudi Arabia. BMC Med Genet. 2016;17:69 pubmed
    ..analysis of 171 consent patients with RPL was performed by the standard method of 72-h lymphocyte culture and GTG banding...
  60. Grub E, Wydra G, Käfer M, Kollner V. [Changes of Motor Balance in the Course of an Inpatient Psychosomatic Rehabilitation]. Rehabilitation (Stuttg). 2017;56:389-396 pubmed publisher
    ..4 % women) were examined at the beginning and the end of rehabilitation. To measure motor balance the balance test (GGT) of Bös, Wydra and Karisch, the timed up and go test (TUG), eight tasks of standing balance on an unstable surface ..
  61. Bindal S, Gupta R. Hyperproduction of ?-glutamyl transpeptidase from Bacillus licheniformis ER15 in the presence of high salt concentration. Prep Biochem Biotechnol. 2017;47:163-172 pubmed publisher
    ..In the current study, production of GGT from Bacillus licheniformis ER15 was investigated to achieve high GGT titers. Hyperproduction of GGT from B...
  62. Alfano A, Romito A, Marchese C, Battistini M, Crotti G, Ferrini A, et al. Diagnostic accuracy of two tests for determination of anti-m2 in the diagnosis of primary biliary cirrhosis: Is it possible to predict the course of the disease?. Immunol Res. 2017;65:299-306 pubmed publisher
    ..We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase of the value EliA-M2...
  63. Tan G, Yuan R, Hao Z, Lei C, Xiong Y, Xu M, et al. Liver Function Indicators Performed Better to Eliminate Cardioembolic Stroke than to Identify It from Stroke Subtypes. J Stroke Cerebrovasc Dis. 2017;26:230-236 pubmed publisher
    ..onset, including alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, gamma-glutamyl transpeptidase (GGT), and bilirubin (BILI), were collapsed into quartiles (Q) and also dichotomized by Q1...
  64. Li Y, Wang J, Huang X, Zeng R, Zhang Q, Lin H, et al. Matrix Effects in Proficiency Testing Materials Influence the Accurate Measurement of Gamma-Glutamyltransferase Activity. Clin Lab. 2016;62:1941-1945 pubmed publisher
    A consensus on an accurate method to measure ?-glutamyltransferase (GGT) activity for clinical purposes has not been achieved among practicing clinical laboratories...
  65. Sáez G, Hebert E, Saavedra L, Zárate G. Molecular identification and technological characterization of lactic acid bacteria isolated from fermented kidney beans flours (Phaseolus vulgaris L. and P. coccineus) in northwestern Argentina. Food Res Int. 2017;102:605-615 pubmed publisher
    ..A combination of phenotypic and genotypic methods including (GTG)5-based PCR fingerprinting and 16S rRNA gene sequencing were used to differentiate and identify the ..
  66. Luo C, Xu B, Fan Y, Yu W, Zhang Q, Jin J. Preoperative Gamma-Glutamyltransferase Is Associated with Cancer-Specific Survival and Recurrence-Free Survival of Nonmetastatic Renal Cell Carcinoma with Venous Tumor Thrombus. Biomed Res Int. 2017;2017:3142926 pubmed publisher
    i>Introduction. To evaluate the prognostic significance of preoperative gamma-glutamyltransferase (GGT) on the subgroup of nonmetastatic renal cell carcinoma (RCC) with venous tumor thrombus. Materials and Methods...
  67. Mańkowska Cyl A, Krintus M, Rajewski P, Sypniewska G. Gamma-glutamyltransferase activity as a surrogate biomarker of metabolic health status in young nondiabetic obese women. Biomark Med. 2017;11:449-457 pubmed publisher
    We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women...
  68. Cantero I, Abete I, Babio N, Aros F, Corella D, Estruch R, et al. Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clin Nutr. 2018;37:1736-1743 pubmed publisher
    ..Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values...
  69. Pucci A, Franzini M, Matteucci M, Ceragioli S, Marconi M, Ferrari M, et al. b-Gamma-glutamyltransferase activity in human vulnerable carotid plaques. Atherosclerosis. 2014;237:307-13 pubmed publisher
    ..Total serum gamma-glutamyltransferase (GGT) activity is an independent predictor for cardiovascular events...
  70. Nagib S, Glaeser S, Eisenberg T, Sammra O, Lämmler C, Kämpfer P, et al. Fatal infection in three Grey Slender Lorises (Loris lydekkerianus nordicus) caused by clonally related Trueperella pyogenes. BMC Vet Res. 2017;13:273 pubmed publisher
    ..relationship between the three isolates could be shown by four genomic DNA fingerprint methods (ERIC-PCR, BOX-PCR, (GTG)5-PCR, and RAPD-PCR) and by multilocus sequence analysis (MLSA) investigating four different ..
  71. Ding Y, Zhao L, Mei H, Huang Z, Zhang S. Alterations of biliary biochemical constituents and cytokines in infantile hepatitis syndrome. World J Gastroenterol. 2006;12:7038-41 pubmed
    ..including total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gamma-GT), total bile acid (TBA), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) both ..
  72. Han L, Hiratake J, Kamiyama A, Sakata K. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase. Biochemistry. 2007;46:1432-47 pubmed
    Gamma-glutamyl transpeptidase (GGT, EC 2.3.2...
  73. Fornaciari I, Fierabracci V, Corti A, Aziz Elawadi H, Lorenzini E, Emdin M, et al. Gamma-glutamyltransferase fractions in human plasma and bile: characteristic and biogenesis. PLoS ONE. 2014;9:e88532 pubmed publisher
    Total plasma gamma-glutamyltransferase (GGT) activity is a sensitive, non-specific marker of liver dysfunction...
  74. Ogusu N, Saruwatari J, Nakashima H, Noai M, Nishimura M, Deguchi M, et al. Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. PLoS ONE. 2014;9:e111066 pubmed publisher
    ..These results suggest that determining the SOD2 genotype could be helpful for preventing the VPA-induced γ-GT elevation. ..
  75. Shen Z, Mannion A, Whary M, Muthupalani S, Sheh A, Feng Y, et al. Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice. Infect Immun. 2016;84:2307-2316 pubmed publisher
    ..pylori These include flagellin, γ-glutamyl transpeptidase (ggt), collagenase, the secreted serine protease htrA, and components of a type VI secretion system, but ..
  76. Wen Y, Yang X, Zeng L, Peng H, Huang W, Cai L, et al. Prognostic impact of pretherapeutic gamma-glutamyltransferase on patients with nasopharyngeal carcinoma. PLoS ONE. 2017;12:e0172345 pubmed publisher
    Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme involved in the metabolism of glutathione. Studies suggested that GGT played an important role in the tumor development, progression, invasion and drug resistance and prognosis...
  77. Price A, Weir C, Welsh P, McLachlan S, Strachan M, Sattar N, et al. Comparison of non-traditional biomarkers, and combinations of biomarkers, for vascular risk prediction in people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Atherosclerosis. 2017;264:67-73 pubmed publisher
    ..N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitivity cardiac troponin (hs-cTnT), gamma-glutamyl transpeptidase (GGT) and four markers of systemic inflammation), both individually and in combination, on cardiovascular ..
  78. Shimizu Y, Ichihara K, Nakajima K. Biological sources of variation of serum adiponectin among healthy individuals in comparison with related nutritional and inflammatory markers. Clin Chim Acta. 2017;472:105-111 pubmed publisher
    ..We chose test results of 11 analytes known as nutritional and inflammatory markers: insulin, HDL-C, LDL-C, TG, ALT, GGT, UA, TTR, CRP, C3, and C4. Factor analysis (FA) was performed to elucidate commonality among the analytes...
  79. Xie W, Cao Y, Xu M, Wang J, Zhou C, Yang X, et al. Prognostic Significance of Elevated Cholestatic Enzymes for Fibrosis and Hepatocellular Carcinoma in Hospital Discharged Chronic Viral Hepatitis Patients. Sci Rep. 2017;7:10289 pubmed publisher
    ..China between February and September 2013 to determine the prevalence of elevated cholestatic enzymes (ALP and/or GGT above ULN) in discharged Chinese patients with CVH as a primary outcome and secondarily evaluated the relationship ..
  80. Iwasaki T, Yoneda M, Kawasaki S, Fujita K, Nakajima A, Terauchi Y. Hepatic fat content-independent association of the serum level of gamma-glutamyltransferase with visceral adiposity, but not subcutaneous adiposity. Diabetes Res Clin Pract. 2008;79:e13-4 pubmed
    We investigated the association between the serum level of gamma-glutamyltransferase (GGT) and parameters of adiposity and lipid profile, including the serum triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels ..
  81. Bianchi C, Penno G, Del Prato S, Miccoli R. Serum gamma-glutamyltransferase is not associated to peripheral arterial disease in type 2 diabetic patients: Cross-sectional findings. Atherosclerosis. 2009;203:49-50 pubmed publisher
  82. Speliotes E, Butler J, Palmer C, Voight B, Hirschhorn J. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology. 2010;52:904-12 pubmed publisher
    ..Genetic variation at PNPLA3 confers a markedly increased risk of increasingly severe histological features of NAFLD, without a strong effect on metabolic syndrome component traits. ..
  83. Fukuda T, Hamaguchi M, Kojima T, Ohshima Y, Ohbora A, Kato T, et al. Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study. BMJ Open. 2014;4:e005413 pubmed publisher
    The purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for ..
  84. Lee Y, Cho Y, Burgess S, Davey Smith G, Relton C, Shin S, et al. Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study. Hum Mol Genet. 2016;25:3877-3886 pubmed publisher
    Elevated gamma-glutamyl transferase (GGT) levels are associated with higher risk of type 2 diabetes in observational studies, but the underlying causal relationship is still unclear...
  85. Ihn K, Ho I, Chang E, Han S. Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia. J Pediatr Surg. 2018;53:461-467 pubmed publisher
    The role of serum gamma-glutamyl transpeptidase (GGT) levels in predicting clinical outcomes after Kasai portoenterostomy (KPE) is unknown...
  86. Dai Y, Liu J, Yuan E, Lee Y, Wang Q, Jia L, et al. ANNALS EXPRESS: Gestational age-specific reference intervals for 15 biochemical measurands during normal pregnancy in China. Ann Clin Biochem. 2017;:4563217738801 pubmed publisher
    ..This study aimed to establish essential to establish reference intervals for a range of analytes during pregnancy...
  87. Domingues J, Cattani D, Cesconetto P, Nascimento de Almeida B, Pierozan P, Dos Santos K, et al. Reverse T3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: Insight on signaling mechanisms. Mol Cell Endocrinol. 2018;470:281-294 pubmed publisher
    ..influx, aspartate transaminase (AST), glutamine synthetase (GS) and gamma-glutamate transferase (GGT) activities, as well as glutathione (GSH) levels in hypothyroid hippocampus...
  88. Han G, Qin C, Ren W, Shi J, Liu H. [The value of gamma-glutamyl transpeptidase mRNA typing in monitoring carcinogensis of heptocytes]. Zhonghua Nei Ke Za Zhi. 2002;41:160-2 pubmed
    To explore the relationship between the alteration in gamma-glutamyl transpeptidase (GGT) mRNA expression and the development of hepatocellular carcinoma (HCC)...
  89. Yagmur J, Ermis N, Acikgoz N, Cansel M, Atas H, Karakus Y, et al. Elevated serum gamma-glutamyl transferase activity in patients with cardiac syndrome X and its relationship with carotid intima media thickness. Acta Cardiol. 2010;65:515-9 pubmed
    We aimed to evaluate serum gamma-glutamyl transferase (GGT) activity and its relationship with carotid intima media thickness (CIMT) in patients with cardiac syndrome X (CSX)...
  90. Tiwari A, Mahdi A, Mishra S. Assessment of liver function in pregnant anemic women upon oral iron and folic acid supplementation. J Gynecol Obstet Hum Reprod. 2018;47:45-49 pubmed publisher
    ..Moreover, gamma-glutamyl transpeptidase (GGT) was found to decrease in pre and posttreated subjects...
  91. Ikeda Y, Fujii J, Taniguchi N, Meister A. Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit. J Biol Chem. 1995;270:12471-5 pubmed
  92. Arrese M. Cholestasis during pregnancy: rare hepatic diseases unmasked by pregnancy. Ann Hepatol. 2006;5:216-8 pubmed
    ..include patients diagnosed in the first trimester of pregnancy, with elevated serum levels of gamma-glutamyl transpeptidase and clear evidence of chronic liver disease...