glutaminyl cyclase

Summary

Gene Symbol: glutaminyl cyclase
Description: glutaminyl-peptide cyclotransferase
Alias: GCT, sQC, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, glutamyl cyclase
Species: human

Top Publications

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
  4. doi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
  5. doi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
  9. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000

Detail Information

Publications211 found, 100 shown here

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
    ..In either 30- or 90-day-old wild-type male mice, the granular convoluted tubules (GCT) of the glands were more developed, and the relative occupied areas (ROA) of GCT were superior to those of the age-..
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    b>Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer's disease (AD) Abeta peptides in vivo...
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
    Giant cell tumor (GCT) of bone is an aggressive non-cancerous tumor, which consists of multi-nucleated osteoclast-like giant cells, stromal cells, and monocytes...
  4. doi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
    To compare different cut-off values of fasting and random plasma glucose as a screening test for diagnosis of gestational diabetes in comparison to the 50 grams Glucose Challenge Test (GCT).
  5. doi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
    ..aim of this study was to relate the incidence of testicular germ cell neoplastic lesions (overt germ cell tumours--GCT or testicular carcinoma in situ) to the intensity of testicular organogenesis disturbances (dysgenesis)...
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
    ..These findings indicate that in vivo the post-translational conversion of a glutaminyl-peptide into a pyroglutamyl-peptide is neither spontaneous nor abiotic as has been previously proposed...
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
    ..We describe here the crystal structure of glutaconate CoA-transferase (GCT) from the strictly anaerobic bacterium Acidaminococcus fermentans...
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
    Thirty consecutive patients with relapsing germ cell tumours (GCT) were treated with induction chemotherapy and high-dose chemotherapy consolidation (HDCT)...
  9. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
    Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage...
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000
    ..administered plus peripheral blood-derived stem-cell (PBSC) support for patients with germ cell tumors (GCT) who have unfavorable prognostic features in response to conventional-dose salvage programs...
  11. ncbi [Pregnant outcomes and neonatal anthropometry in women with abnormal glucose challenge test and normal oral glucose tolerance test during pregnancy.]
    Hai Tian Chen
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Fu Chan Ke Za Zhi 44:801-4. 2009
    To evaluate the influences of abnormal glucose challenge test(GCT) on pregnancy outcomes and neonatal anthropometric data in women with normal oral glucose tolerance test(OGTT).
  12. doi Giant cell tumor of the cervical spine: a series of 22 cases and outcomes
    Ma Junming
    The Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 33:280-8. 2008
    ..A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003...
  13. ncbi Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning
    K Sugiyama
    Department of Neurosurgery, Hiroshima University Medical Hospital, Japan
    Brain Tumor Pathol 18:115-22. 2001
    Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP)...
  14. ncbi Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidases
    J Pedersen
    UNIZYME Laboratories, Dr Neergaards vej 17, Horsholm, DK 2970, Denmark
    Protein Expr Purif 15:389-400. 1999
    ..the aminopeptidase dipeptidyl peptidase I (DPPI), either alone or in combination with glutamine cyclotransferase (GCT) and pyroglutamyl aminopeptidase (PGAP)...
  15. ncbi Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor
    Madhu Mazumdar
    Memorial Sloan Kettering Cancer Center, 307 E 63rd St, 3rd Floor, New York, NY 10021, USA
    J Clin Oncol 21:2679-88. 2003
    ..information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation...
  16. ncbi Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..Recently, we have identified the expression of both MMP-2 and MMP-9 in primary cultures of human giant cell tumor (GCT) of bone in vitro, and in tissue extracts in vivo. Interestingly, MMP-9 is not secreted by late-passaged GCT cells...
  17. pmc Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody ..
  18. ncbi Can adiponectin predict gestational diabetes?
    Sawaek Weerakiet
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Gynecol Endocrinol 22:362-8. 2006
    ..and number of fetuses by ultrasound, all women underwent a 1-h glucose challenge test with 50 g glucose load (50-g GCT) between 21 and 27 weeks of GA...
  19. ncbi Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
    ....
  20. ncbi False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)--an update
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 43:516-21. 2003
    ..neoplasia (TIN; or carcinoma in situ of the testis) is the precursor of testicular germ-cell tumours (GCT). It is detected by conventional surgical biopsy of the testis...
  21. doi Stereotactic radiosurgery for pineal and related tumors
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Prog Neurol Surg 23:106-18. 2009
    ..The mean treatment volume was 3.3 ml (range 0.1-22 ml) in GCT cases and 3.7 ml (range 0.3-23 ml) in PPT cases. Prescribed doses around 50% isodose line ranged from 9.9 to 25...
  22. ncbi Effects of electrohydraulic extracorporeal shock wave lithotripsy on submandibular gland in the rat: electron microscopic evaluation
    Nuray Bayar
    Kirikkale University, Faculty of Medicine, ENT Department, Kirikkale, Turkey
    Int J Pediatr Otorhinolaryngol 63:223-33. 2002
    ..The aim of this experimental study is to investigate the local effects of electrohydraulic ESWL applied to the right submandibular gland of the rats...
  23. ncbi Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    J Interferon Cytokine Res 19:1207-17. 1999
    Giant cell tumor (GCT) of bone is a progressive, potentially malignant process that destroys skeletal tissue...
  24. ncbi Giant cell tumor of bone: a model for the in vitro human osteoclast characterization
    M Campanacci
    Centro Interdipartimentale di Ricerche sul Cancro, Giorgio Prodi, , Italy
    Tumori 75:389-95. 1989
    The in vitro growth pattern of cells obtained from bioptic material of ten patients with giant cell tumor of bone (GCT) was investigated...
  25. doi The epidemiology of ovarian granulosa cell tumors: a case-control study
    E A Boyce
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, USA
    Gynecol Oncol 115:221-5. 2009
    This study identified risk factors for ovarian granulosa cell tumors (GCT) through a case-control study comparing women with GCT to women with epithelial ovarian cancers (OC) and general population (GP) controls.
  26. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal ..
  27. ncbi Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection
    Natale Alfredo Santagati
    Dipartimento di Scienze Farmaceutiche, Università di Catania Viale A Doria 6, 95125 Catania, Italy
    J Chromatogr Sci 46:150-6. 2008
    ..for the simultaneous analysis of five major catechins: (+)-catechin (C), (-)-epicatechin (EC), (-)-gallocatechin (GCT), (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCG), and the phenolic plant metabolites gallic acid (..
  28. pmc The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004)
    Jennifer L Beebe-Dimmer
    Karmanos Cancer Institute and Wayne State University Department of Internal Medicine, Detroit, MI
    Rare Tumors 1:e52. 2009
    Malignant giant cell tumor (GCT) of bone is a rare tumor with debilitating consequences...
  29. ncbi Relationship between binuclear and multinuclear cells in giant cell tumor of bone
    K Kusuzaki
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 20:2463-7. 2000
    Giant cell tumor of bone (GCT) consists of stromal and multinuclear type tumor cells...
  30. doi Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment
    Yukihiko Sonoda
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Neurosurg Pediatr 2:118-24. 2008
    ..The authors investigated factors related to the diagnosis of these lesions as well as outcome in order to help decrease the time to diagnosis and improve treatment efficacy...
  31. ncbi Granulosa cell tumor of the ovary
    Susan Tinsley Schumer
    Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 21:1180-9. 2003
    Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen...
  32. ncbi Regular expression of osteopontin in granular cell tumor: distinctive feature among Schwannian cell tumors
    Nobuo Hoshi
    Department of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pathol Int 55:484-90. 2005
    For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors...
  33. ncbi Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    S M Kumta
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
    Life Sci 73:1427-36. 2003
    ..of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
  34. ncbi Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors
    Changning Wang
    Key Laboratory of Oral Biomedical Engineering, Ministry of Education of China, Wuhan University, Wuhan 430079, P R China
    Oncol Rep 15:589-94. 2006
    Cherubism (CBM) and central giant cell granuloma (CGCG) of the jaw and giant cell tumor (GCT) of the long bone are clinically different diseases. Histologically, they are all multinucleated giant cell (MGC)-containing lesions...
  35. ncbi Granular cell tumor of the penis shaft: case report and literature review
    A Dema
    Department of Pathology, University of Medicine and Pharmacy V Babes, Timisoara, Romania
    Chirurgia (Bucur) 104:359-62. 2009
    Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now.
  36. ncbi Identification of markers of possible prognostic value in 57 giant cell tumors of bone
    Gabriella Gamberi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, I 40136 Bologna, Italy
    Oncol Rep 10:351-6. 2003
    Giant cell tumor of bone (GCT) is a neoplasm characterized by the presence of large numbers of multinucleated osteoclast-like giant cells, together with mononuclear spindle-shaped cells...
  37. ncbi Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours
    H Herbst
    Institut fur Pathologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Virchows Arch 434:11-5. 1999
    ..abnormal or dysgenetic gonads, often transforming to invasive seminomatous and nonseminomatous germ cell tumours (GCT)...
  38. ncbi Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration
    M H Zheng
    Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Australia
    J Cell Biochem 70:121-9. 1998
    Giant cell tumor of bone (GCT) is one of a few neoplasms in which the macrophage/osteoclast precursor cells and osteoclast-like giant cells infiltrate the tumor mass...
  39. pmc Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report
    Ran Hong
    Department of Pathology, Chosun University School of Medicine, Gwangju 501 140, South Korea
    World J Gastroenterol 15:3315-8. 2009
    A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin...
  40. doi Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites
    Harpreet Kaur
    Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Int J Clin Oncol 14:78-81. 2009
    Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade...
  41. ncbi Analysis of oral glucose tolerance test in pregnant women with abnormal glucose metabolism
    Hui Xia Yang
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 118:995-9. 2005
    ..tolerance (GIGT) and to evaluate the effect of omission of the third-hour plasma glucose (PG) level in OGTT on the sensitivity of diagnosing GDM and GIGT, and the relationship between PG values of 50 g GCT or OGTT and insulin therapy.
  42. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    ..Serum RBP4 concentrations at glucose challenge test (GCT) were significantly higher in the GDM group (42.4 +/- 13.8 ng/mL) than in the healthy control group (32.0 +/- 8...
  43. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  44. ncbi Inhibin-activin receptor subunit gene expression in ovarian tumors
    Peter J Fuller
    Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 87:1395-401. 2002
    Granulosa cell tumors of the ovary (GCT) express the inhibin subunit genes and secrete dimeric inhibin. Transgenic mice null for the alpha-inhibin gene develop GCT...
  45. ncbi Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation
    Brian H Le
    Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA
    Arch Pathol Lab Med 128:771-5. 2004
    Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue...
  46. ncbi MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India
    C B Sanjeevi
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 958:341-4. 2002
    ..Sequence determination of the MIC-A gene identifies trinucleotide repeat (GCT) microsatellite polymorphism in exon 5...
  47. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    Of all malignancies diagnosed in men between 17 and 45 years of age, 60% are germ cell tumors (GCT). GCT arise from carcinoma in situ cells, which are thought to originate from a transformed fetal germ cell, the gonocyte...
  48. ncbi A population-based risk factor scoring will decrease unnecessary testing for the diagnosis of gestational diabetes mellitus
    Eray Caliskan
    SSK Ankara Maternity and Women s Health Teaching Hospital, Etlik, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:524-30. 2004
    ..To determine the effectiveness of a population-based risk factor scoring to decrease unnecessary testing for the diagnosis of gestational diabetes mellitus (GDM)...
  49. ncbi A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry
    Rainer Lynen
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Transfusion 42:612-8. 2002
    Novel gel centrifugation test (GCT) cards were evaluated with respect to their ability to estimate the quantity of IgG on RBCs and the determination of the IgG subclasses IgG1 and IgG3.
  50. doi [Germ-cell tumors of the central nervous system in childhood: retrospective study of 13 patients]
    J Voirin
    Service de Neurochirurgie, Departement de Neurochirurgie, bâtiment neurologique, Hopital Central, CHU de Nancy, 29, Avenue du Marechal de Lattre de Tassigny, C O n 34, 54035 Nancy Cedex, France
    Neurochirurgie 54:55-62. 2008
    Germ cell tumors (GCT) of the central nervous system are rare (2% of all brain tumors in children)...
  51. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..derived from various cyanobacteria genomes, we designated the seven putative TPx members as VCP, VCT, TCS, and GCT clusters according to the sequence of their conserved catalytic motif...
  52. pmc Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
    Rachell E Booth
    Department of Chemistry and Biochemistry, Texas State University San Marcos, San Marcos, TX 78666, USA
    BMC Biol 2:2. 2004
    b>Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases...
  53. ncbi Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique
    G Battaglia
    Istituto Oncologico Veneto IOV, via Giogtinian 12, Padova, 35100, Italy
    Surg Endosc 20:1296-8. 2006
    ..The single-band mucosectomy technique was used to remove a granular cell tumor (GCT) of the esophagus. Only 3% of GCTs, which are relatively uncommon neoplasms, arise in the esophagus...
  54. ncbi Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..Consecutive Japanese women with singleton pregnancies underwent a standard 1h, 50g oral glucose challenge test (GCT) at 24-27 weeks of gestation, followed by a 75g, 2h oral glucose tolerance test (OGTT) if the GCT result exceeded ..
  55. ncbi [Diagnostic of gestational diabetes mellitus and the prevalence of LGA (Large for Gestational Age)]
    Monika Szymanska
    I Katedra i Klinika Połoznictwa i Ginekologii w Warszawie
    Ginekol Pol 79:177-81. 2008
    ..The aim of the study was to examine the influence of time and diagnostic method of GDM on the prevalence of LGA and pregnancy outcome among patients with gestational diabetes...
  56. doi Small fetal abdominal circumference in the second trimester and subsequent low maternal plasma glucose after a glucose challenge test is associated with the delivery of a small-for-gestational age neonate
    J L Bienstock
    Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 31:517-9. 2008
    To evaluate the predictive value of a combination of the 1 h 50-g glucose challenge test (GCT) and second-trimester ultrasound measurement of fetal abdominal circumference (AC) in identifying patients who will go on to deliver small-for-..
  57. ncbi Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..was to determine the characteristics and clinical usefulness of 201Tl scintigraphy in giant-cell tumour of bone (GCT)...
  58. doi Colorectal granular cell tumor: a clinicopathologic study of 26 cases
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1186-92. 2010
    Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA)...
  59. pmc Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
    Hsei Wei Wang
    School of Life Sciences, Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    BMC Genomics 11:132. 2010
    ..The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlying the differences in incidence and prognosis of the various GCT subgroups are unclear.
  60. ncbi Importance of angulate bodies in the diagnosis of granular cell tumors (schwannomas)
    P H Carstens
    Department of Pathology, University of Louisville School of Medicine, Kentucky 40292
    Ultrastruct Pathol 17:271-8. 1993
    ..ABs appear to have been forgotten, and the diagnosis of GCT currently depends solely upon the presence of large lysosomes...
  61. ncbi [Granular cell tumor of the orbit]
    I Sterker
    Klinik und Poliklinik für Augenheilkunde, Universitatsklinikum Leipzig, Liebigstrasse 10 14, 04103 Leipzig
    Ophthalmologe 104:803-5. 2007
    Granular cell tumor (GCT, Abrikossoff tumor) is an extremely rare, benign tumor with a neurogenic origin occurring most commonly in the upper aerodigestive tract...
  62. ncbi Chemotherapy for good-risk germ cell tumors: current concepts and controversies
    David J Vaughn
    Division of Hematology Oncology, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Urol Clin North Am 34:171-7; abstract viii-ix. 2007
    ..chemotherapy has evolved such that approximately 90% of patients who have good-risk metastatic germ cell tumor (GCT) will be cured of their disease...
  63. ncbi Molecular analysis of circulating tumor cells in peripheral blood from patients with germ cell tumor: a quantitative approach
    I H Wong
    25F, 4B, The Tolo Place, Ma On Shan, Shatin, New Territories, Hong Kong
    Int J Mol Med 6:491-4. 2000
    Germ cell tumor (GCT) is one of the few malignancies in which recurrent patients would have a good chance of cure by chemotherapy...
  64. ncbi Incidence of large-for-gestational age newborn: a comparison between pregnant women with abnormal and normal screening test for gestational diabetes
    Jiraporn Luengmettakul
    Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand
    J Med Assoc Thai 90:432-6. 2007
    To evaluate the incidence of large-for-gestational age (LGA) newborn between pregnant women with abnormal and normal glucose challenge test (GCT).
  65. ncbi Primary giant cell tumor of soft tissues similar to bone giant cell tumor: A case report and literature review
    J L Rodriguez-Peralto
    Department of Pathology, University Hospital 12 de Octubre, Ctra de Andalucia Km 5400, 28041 Madrid, Spain
    Pathol Int 51:60-3. 2001
    In this report we describe a primary giant cell tumor (GCT) of soft tissues located in the left dorsal wrist of a 52-year-old man. Plain radiographs did not reveal any lesion in his carpal or hand bones...
  66. ncbi Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy
    K Trieb
    Department of Orthopaedics, University of Vienna, Vienna, Austria
    Eur J Surg Oncol 27:200-2. 2001
    Giant-cell tumour of bone (GCT) represents 5% of all primary bone tumours. The aim of this study was to compare the outcome of GCT treated with or without phenol.
  67. pmc GnRH agonist therapy in a patient with recurrent ovarian granulosa cell tumors
    Hyun Jung Kim
    Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea
    J Korean Med Sci 24:535-8. 2009
    ..its long and indolent course and the low metabolic rate of the tumors, advanced or recurrent granulosa cell tumor (GCT) requires treatment options beyond chemotherapy, surgery, and radiotherapy...
  68. doi Third-line chemotherapy and novel agents for metastatic germ cell tumors
    Christine M Veenstra
    Division of Hematology Oncology, University of Pennsylvania, 16 Penn Tower, 3400 Spruce, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 25:577-91, ix. 2011
    Although germ cell tumors (GCT) are among the most curable solid tumors, a subset of patients with GCT experience relapse or progression despite appropriate cisplatin-based therapy or first-line salvage therapy...
  69. doi Gestational diabetes mellitus identification based on self-monitoring of blood glucose
    Catherine Allard
    Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
    Can J Diabetes 39:162-8. 2015
    ..GDM screening during the first trimester for all pregnant women based on a 50 g glucose challenge test (50 g GCT) followed directly by capillary self-monitoring blood glucose (SMBG) at home...
  70. doi Partial-limb salvage after persistent infection in the distal femoral prosthesis: straight-plasty--a novel technique
    Zile Singh Kundu
    Department of Orthopaedics and Rehabilitation, PGIMS, Rohtak, Haryana, India 124001
    J Coll Physicians Surg Pak 24:213-5. 2014
    A 35 years old female had giant cell tumour (GCT) of the distal femur for which wide resection and distal femoral endoprosthetic replacement was performed...
  71. ncbi Giant cell tumor complicating Paget disease of long bone
    Benjamin Hoch
    Department of Pathology, Mount Sinai Medical Center, One Gustave L Levy Place, Box 1194, New York, NY 07422, USA
    Skeletal Radiol 36:973-8. 2007
    Giant cell tumor (GCT) is a rare complication of Paget disease of bone. It usually occurs in the skull or pelvic bones of patients with long-standing polyostotic disease...
  72. ncbi Histomorphological and immunohistochemical characterization of equine granulosa cell tumours
    C Ellenberger
    Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Germany
    J Comp Pathol 136:167-76. 2007
    ..Availability permitting, serum samples from GCT-affected mares before and several weeks after ovariectomy were examined for the following hormones: oestradiol, ..
  73. ncbi Use of fluorodeoxyglucose positron emission tomography scans in patients with advanced germ cell tumour following chemotherapy: single-centre experience with long-term follow up
    C S Karapetis
    Department of Medical Oncology, Guy s Hospital, London, United Kingdom
    Intern Med J 33:427-35. 2003
    ..emission tomography (FDG-PET) may detect residual or recurrent malignancy in patients with germ cell tumours (GCT) following chemotherapy...
  74. ncbi Polymorphism of the MICA gene and risk for oral submucous fibrosis
    Chung Ji Liu
    Departments of Oral and Maxillofacial Surgery, Taipei Mackay Memorial Hospital, School of Dentistry, National Yang Ming University, Taipei, Taiwan
    J Oral Pathol Med 33:1-6. 2004
    ..The MICA gene has a triplet repeat (GCT) polymorphism in the transmembrane domain resulting in five distinct allelic patterns.
  75. doi Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl
    G Calaminus
    Pediatric Hematology and Oncology, University Munster, Munster, Germany
    Klin Padiatr 222:175-9. 2010
    Germ cell tumors (GCT) situated in the head and neck region are very rare and occur predominantely in newborns or young infants...
  76. doi The Psychological Inventory of Criminal Thinking Styles and Psychopathy Checklist: screening version as incrementally valid predictors of recidivism
    Glenn D Walters
    Psychology Services, Federal Correctional Institution, FCI Schuylkill, P O Box 700, Schuylkill, Minersville, Pennsylvania 17954 0700, USA
    Law Hum Behav 33:497-505. 2009
    ..The PICTS General Criminal Thinking (GCT) score was found to predict general recidivism and serious recidivism when age, prior charges, and the PCL:SV were ..
  77. ncbi [Diagnosis and management of granular cell tumor of the larynx]
    Dan Lv
    Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 27:116-8. 2013
    To investigate the histogenesis, morphological features and biologic behaviors of granular cell tumor(GCT) of the larynx.
  78. doi Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11
    K A Schrader
    Department of Medical Genetics, University of British Columbia, British Columbia, Canada
    Clin Genet 75:185-9. 2009
    ..with molecularly characterized LS and provides the first molecular evidence linking granular cell tumors (GCT) to the Ras/mitogen-activated protein (MAP) kinase pathway. We propose that MGCT can be associated with LS...
  79. ncbi False-positive 1-hour glucose challenge test and adverse perinatal outcomes
    David M Stamilio
    Center for Clinical Epidemiology and Biostatistics and Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 103:148-56. 2004
    To determine whether a false-positive 1-hour glucose challenge test (GCT) is associated with perinatal complications.
  80. pmc Molecular characterization of tick salivary gland glutaminyl cyclase
    Steven W Adamson
    Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406, USA
    Insect Biochem Mol Biol 43:781-93. 2013
    b>Glutaminyl cyclase (QC) catalyzes the cyclization of N-terminal glutamine residues into pyroglutamate...
  81. ncbi Granular cell tumor of the neurohypophysis: case report and review of the literature
    Leonard Saiegh
    Department of Endocrinology, Bnai Zion Medical Center, Haifa, Israel
    Neuro Endocrinol Lett 34:331-8. 2013
    ..by the fronto-temporal approach, and histology met the diagnosis of neurohypophesial granular cell tumor (GCT)...
  82. doi Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult
    Akihiro Kuriu
    Department of Radiology, Kinki University School of Medicine, Osaka Sayama, Japan
    Jpn J Radiol 28:166-8. 2010
    We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man. Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue...
  83. doi Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor
    Y Ehrlich
    Department of Urology, Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA
    Ann Oncol 21:1846-50. 2010
    The emergence of a primitive neuroectodermal tumor (PNET) within a germ-cell tumor (GCT) is rare. We assess the prognosis and response to treatment.
  84. doi Successful treatment of metastatic βHCG-secreting germ cell tumor occurring 3 years after total resection of a pineal mature teratoma
    Stefania Cardellicchio
    Neuro Oncology Unit, Department of Paediatric Medicine, Meyer Children s University Hospital, viale G Pieraccini 24, 50139, Florence, Italy
    Eur J Pediatr 173:1011-5. 2014
    ..underwent chemotherapy with PEI (cis-platinum, etoposide, ifosfamide) followed by radiation therapy according to the SIOP CNS GCT protocol. The patient is currently alive without evidence of disease 35 months after starting therapy.
  85. ncbi Kinetics of tumor marker decline as an independent prognostic factor in patients with relapsed metastatic germ-cell tumors
    M Mego
    Department of Medical Oncology, Comenius University, Bratislava, Slovakia
    Neoplasma 56:398-403. 2009
    ..chemotherapy was shown to predict survival in patients with poor prognosis non-seminomatous germ cell tumors (GCT) in the first line. The aim of the study was to assess the prognostic value of STMD in relapsed GCT;s patients...
  86. ncbi Primary malignancy in giant cell tumor: a case report
    Rosalvo Zosimo Bispo Junior
    Department of Orthopedics and Traumatology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    Sao Paulo Med J 127:310-3. 2009
    Primary malignancy in giant cell tumor (PMGCT) is rare. It is defined as a high-grade sarcoma originating in a giant cell tumor (GCT) and seems to behave less aggressively than its secondary counterpart does.
  87. doi Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893
    M F Covington
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    AJNR Am J Neuroradiol 32:2067-72. 2011
    Pituicytoma, SCO, and GCT are poorly understood entities with confusing nomenclature and undetermined imaging characteristics...
  88. doi 3D gastric computed tomography as a new imaging in patients with failure or complication after bariatric surgery
    Marie Cécile Blanchet
    Service de Chirurgie Digestive, Hopital de la Croix Rousse, Lyon, France
    Obes Surg 20:1727-33. 2010
    ..In our centre, we have developed 3D gastric computed tomography with air (3D-GCT)...
  89. ncbi Reovirus serotype 1/strain Lang-stimulated activation of antigen-specific T lymphocytes in Peyer's patches and distal gut-mucosal sites: activation status and cytotoxic mechanisms
    Mantej S Bharhani
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 174:3580-9. 2005
    ..Our earlier studies demonstrated that germinal center and T cell Ag (GCT) is a marker which identifies reovirus 1/L-specific precursor CTL and effector CTL in Peyer's patches (PP) of ..
  90. doi Surgical resection and reconstruction for a giant cell tumor of the anterior rib
    Akira Mogi
    Department of General Surgical Science, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Gen Thorac Cardiovasc Surg 60:233-6. 2012
    ..GCTs rarely appear in the ribs. We report a case of a GCT originating from the anterior arc of the fourth rib in a 31-year-old man who presented with a progressively growing ..
  91. ncbi Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature
    Ko Hashimoto
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 208:157-62. 2006
    Giant cell tumor of the bone (GCT) is a relatively uncommon tumor. It is characterized by the presence of multinucleated giant cells. GCT is a primary benign tumor but may evolve into a malignant tumor, usually after irradiation...
  92. doi Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms
    J E Nielsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:e207-15. 2010
    ..and lipoprotein lipase (LPL) mRNA and protein expression in normal human testis and testicular germ cell tumours (GCT). Both EL and LPL were expressed in normal seminiferous tubules and in the interstitial compartment...
  93. doi Gonadal development and tumor formation at the crossroads of male and female sex determination
    M Cools
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Ghent and Ghent University, Belgium martine cools ugent be
    Sex Dev 5:167-80. 2011
    Malignant germ cell tumor (GCT) formation is a well-known complication in the management of patients with a disorder of sex development (DSD)...
  94. pmc Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody
    Markus Mandler
    AFFiRiS AG, Vienna Biocenter, Vienna, Austria
    J Alzheimers Dis 28:783-94. 2012
    ..Among them, recent studies indicate that the pyroglutamate modification of Aβ (pE(3)Aβ) catalyzed by glutaminyl cyclase might play an important role in the pathogenesis of AD...
  95. doi Granulosa cell tumor of the broad ligament: report of a case with emphasis on the differential diagnosis with female adnexal tumor of probable Wolffian origin
    Bernard Czernobilsky
    Patho Lab Diagnostics, Ness Ziona, Israel
    Int J Surg Pathol 19:783-6. 2011
    This is a report of a paratubal adult granulosa cell tumor (GCT) located within the right broad ligament in a 62-year-old woman. These are rare tumors with only 8 cases reported so far...
  96. ncbi Granulosa cell tumor and endometrial cancer: a case report and review of the literature
    M Busquets
    Department of Obstetrics and Gynecology, Sant Joan de Déu University Hospital, Barcelona, Spain
    Eur J Gynaecol Oncol 31:575-8. 2010
    ..We report an atypical case of ovarian cancer with the aim of reviewing the clinical features of GCT, as well as its prognosis, treatment and follow-up recommendations, according to the available literature.
  97. pmc X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms
    Rahul Sharma
    Center for Inflammation, Immunity, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Immunol 183:3212-8. 2009
    ..A strong correlation was observed between the development of the granular convoluted tubules (GCT) of the SMG in these mice and SMG resistance to inflammation. Moreover, GCT development in Sf...
  98. ncbi Germ cell tumours in neonates and infants: a distinct subgroup?
    Imke M Veltman
    Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    APMIS 111:152-60; discussion 160. 2003
    ..Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations...
  99. doi Diagnosis of gestational diabetes mellitus: can we avoid the glucose challenge test?
    Joan E Crete
    Department of Obstetrics and Gynecology, St Luke s Hospital and Health Network, Bethlehem, Pennsylvania
    J Am Assoc Nurse Pract 25:329-33. 2013
    ..in patients who had either a normal or abnormal glucose tolerance test (GTT) after failing the initial glucose challenge test (GCT). If identified, consideration can be given to circumvent the glucose challenge test for those at risk.
  100. ncbi The influence of adjuvants on local recurrence rate in giant cell tumour of the bone
    M F Pietschmann
    Department of Orthopaedics, Campus Grosshadern, Ludwig Maximilians University, Munich, Germany
    Acta Chir Belg 110:584-9. 2010
    Intralesional surgery of giant cell tumour of the bone (GCT) may result in a high rate of local recurrence...
  101. doi Silencing of the UCHL1 gene in giant cell tumors of bone
    Jorg Fellenberg
    Department of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 127:1804-12. 2010
    ..cells develop from mesenchymal stem cells (MSCs) but little is known about the molecular mechanisms involved in GCT tumorigenesis...

Research Grants39

  1. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2013
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  2. Mouse model for juvenile granulosa cell tumorogenesis
    ROSEMARY STEINEMETZ; Fiscal Year: 2004
    ..In order to test the hypothesis that the FSH-R pathway is involved in GCT pathogenesis, we will utilize a unique mouse model for GCT formation...
  3. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment ..
  4. Pyroglutamate Amyloid-beta as an Immunotherapeutic Target for Alzheimer's Disease
    Cynthia A Lemere; Fiscal Year: 2013
    ..A[unreadable] is generated upon N-terminal truncation of A[unreadable] followed by cyclization by glutaminyl cyclase to convert glutamic acid at residues 3 and 11 to pyroglutamate (A[unreadable]pE3 and A[unreadable]pE11)...
  5. Molecular Epidemiology of Pediatric Germ Cell Tumors
    Jenny N Poynter; Fiscal Year: 2013
    ..Cases of pediatric GCT (ages 0-19 years) diagnosed from July 1, 2008-December 31, 2015 will be identified through the CCRN and will be ..
  6. A pilot study of DNA methylation in pediatric germ cell tumors
    Jenny N Poynter; Fiscal Year: 2010
    ..by environmental exposures, with the goal of establishing a large genetic epidemiology study of pediatric GCT in the Children's Oncology Group...
  7. Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    Vivian Y H Hook; Fiscal Year: 2013
    ..aminopeptidase enzymes generate A [unreadable] (3-40/42) which is converted to pGluA[unreadable](3-40/42) by glutaminyl cyclase (QC)...
  8. TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.
    Mary Vore; Fiscal Year: 2013
    ..The Training Program is based in the Graduate Center for Toxicology (GCT), a basic science department in the College of Medicine that grants the Ph.D...
  9. Agilent 6550 QTOF system for U of Utah
    JAMES ERIC COX; Fiscal Year: 2013
    ..This system will complement our current Waters GCT-Premier GC-MS and will be used immediately at full capacity...
  10. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  11. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..The major source of mouse EGF is the granular convoluted tubule (GCT) cells of the submandibular salivary gland, which also produce nerve growth factor, renin and kallikreins...
  12. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  13. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 2000
    ..g., bax, bcl-2, p21) will be assessed. His preliminary data in two GCT cell lines (one drug-sensitive (TP53 wild-type) and one drug-resistant (TP53 mutant)) show failure to upregulate ..
  14. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  15. ANTIOXIDANT ENZYMES AND CARDIAC INJURY
    Daret St Clair; Fiscal Year: 2000
    ..courses but will also participate in a number of team-taught courses offered by the Graduate Center for Toxicology (GCT)...
  16. Therapeutic/Mechanistic Role of Ape1 in Germ Cell Tumors
    Mark Kelley; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Therapy for disseminated germ cell tumors (GCT) has been successful with 70-80% of patients being cured with front line chemotherapy...
  17. BIOLOGY OF HIGH RISK GERM CELL NEOPLASIA
    Lawrence Einhorn; Fiscal Year: 2001
    OVERALL DESCRIPTION (Applicant's Description): Germ cell tumors (GCT), while uncommon, are still the leading cause of cancer in young adult males...
  18. Development of an Aging and Cancer Program at MSKCC
    George Bosl; Fiscal Year: 2007
    ..Through this planning grant, MSKCC will formally expand its research activities in cancer biology and management in the aging population so that it will become a key component of its NCI-funded CCSG. ..
  19. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  20. Molecular Basis Of Renal Cell Carcinoma Response to SU11428
    Robert J Motzer; Fiscal Year: 2011
    ..These tumor and cell line-based studies lay a foundation for further molecular studies aimed at understanding the sensitivity/resistance of RCC to SU11248. ..
  21. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  22. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  23. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  24. IMPROVING PRIMARY CARE OF AFRICAN AMERICANS WITH NIDDM
    Lawrence Phillips; Fiscal Year: 2001
    ..Our interventions should delineate approaches effective in a primary care setting, as needed to improve care and prevent complications in urban African-Americans with NIDDM. ..
  25. MOLECULAR CYTOGENETICS OF MULTIPLE MYELOMA
    Raju Chaganti; Fiscal Year: 2001
    ..abstract_text> ..
  26. Outcomes of Cx26 Testing in Deaf/Hard of Hearing Adults
    Christina Palmer; Fiscal Year: 2009
    ....
  27. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  28. Impaired Glucose Challenge Test & Maternal-Fetal Outcomes
    Xinhua Chen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Molecular Genetics of Cervical Cancer Progression
    Murty Vundavalli; Fiscal Year: 2004
    ..The data generated from these studies will be used to determine the clinical significance and to develop a genetic prognostic model for identifying high-risk CINs that progress into invasive cancer. ..
  30. Cardiovascular Risk in Testicular Cancer Survivors
    David Vaughn; Fiscal Year: 2004
    ..However, prior to initiating an intervention study, these parameters need to be explicated. ..
  31. MAPPING CHROMOSOMES AND GENES IN RELATION TO LEUKEMIA
    Raju Chaganti; Fiscal Year: 2005
    ..In addition, the mapping of NHL breakpoints will provide a platform for addressing breakpoints in this region found in other cancer types. ..
  32. Regulation of embryonic stem cells
    Martin Pera; Fiscal Year: 2005
    ..This project will use stem cell lines ES 01 02 03 04 05 06 on the NIH Embryonic Stem Cell Registry. ..
  33. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  34. Connexin 26 Testing in Infants
    Christina Palmer; Fiscal Year: 2005
    ..A large cohort of infants and toddlers will be followed for up to three years to fully evaluate the audiologic phenotype of infants and data will be compared based on Cx26 genotype. ..
  35. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  36. NEUROENDOCRINE CONTROL OF REPRODUCTIVE BEHAVIOR
    LAUREN RITERS; Fiscal Year: 2003
    ..In addition, this research could lay the groundwork for future studies on the etiology of disorders related to sexual arousal...
  37. GENES, ANTICARCINOGENS AND COLON NEOPLASMS
    Henry Lin; Fiscal Year: 2006
    ..Results may lead to better understanding of protective mechanisms involving aspirin and nonsteroidal anti-inflammatory drugs. ..
  38. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  39. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..