glutaminyl cyclase

Summary

Gene Symbol: glutaminyl cyclase
Description: glutaminyl-peptide cyclotransferase
Alias: GCT, sQC, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, glutamyl cyclase
Species: human

Top Publications

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
  4. doi Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study
    Nasjla Saba da Silva
    Department of Pediatric Oncology, IOP GRAACC UNIFESP, Sao Paulo, SP, Brazil
    Pediatr Blood Cancer 54:377-83. 2010
  5. doi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
  9. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000

Research Grants

  1. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2011
  2. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2010
  3. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2007
  4. Cyclin D as a Retinoid Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2007
  5. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003
  6. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
  7. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
  8. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
  9. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
  10. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2007

Detail Information

Publications153 found, 100 shown here

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
    ..In either 30- or 90-day-old wild-type male mice, the granular convoluted tubules (GCT) of the glands were more developed, and the relative occupied areas (ROA) of GCT were superior to those of the age-..
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    b>Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer's disease (AD) Abeta peptides in vivo...
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
    Giant cell tumor (GCT) of bone is an aggressive non-cancerous tumor, which consists of multi-nucleated osteoclast-like giant cells, stromal cells, and monocytes...
  4. doi Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study
    Nasjla Saba da Silva
    Department of Pediatric Oncology, IOP GRAACC UNIFESP, Sao Paulo, SP, Brazil
    Pediatr Blood Cancer 54:377-83. 2010
    The treatment of central nervous system (CNS) germ cell tumors (GCT) remains controversial...
  5. doi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
    To compare different cut-off values of fasting and random plasma glucose as a screening test for diagnosis of gestational diabetes in comparison to the 50 grams Glucose Challenge Test (GCT).
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
    ..These findings indicate that in vivo the post-translational conversion of a glutaminyl-peptide into a pyroglutamyl-peptide is neither spontaneous nor abiotic as has been previously proposed...
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
    ..We describe here the crystal structure of glutaconate CoA-transferase (GCT) from the strictly anaerobic bacterium Acidaminococcus fermentans...
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
    Thirty consecutive patients with relapsing germ cell tumours (GCT) were treated with induction chemotherapy and high-dose chemotherapy consolidation (HDCT)...
  9. doi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
    Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage...
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000
    ..administered plus peripheral blood-derived stem-cell (PBSC) support for patients with germ cell tumors (GCT) who have unfavorable prognostic features in response to conventional-dose salvage programs...
  11. ncbi [Pregnant outcomes and neonatal anthropometry in women with abnormal glucose challenge test and normal oral glucose tolerance test during pregnancy.]
    Hai Tian Chen
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Fu Chan Ke Za Zhi 44:801-4. 2009
    To evaluate the influences of abnormal glucose challenge test(GCT) on pregnancy outcomes and neonatal anthropometric data in women with normal oral glucose tolerance test(OGTT).
  12. doi Giant cell tumor of the cervical spine: a series of 22 cases and outcomes
    Ma Junming
    The Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 33:280-8. 2008
    ..A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003...
  13. ncbi Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidases
    J Pedersen
    UNIZYME Laboratories, Dr Neergaards vej 17, Horsholm, DK 2970, Denmark
    Protein Expr Purif 15:389-400. 1999
    ..the aminopeptidase dipeptidyl peptidase I (DPPI), either alone or in combination with glutamine cyclotransferase (GCT) and pyroglutamyl aminopeptidase (PGAP)...
  14. ncbi Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor
    Madhu Mazumdar
    Memorial Sloan Kettering Cancer Center, 307 E 63rd St, 3rd Floor, New York, NY 10021, USA
    J Clin Oncol 21:2679-88. 2003
    ..information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation...
  15. ncbi Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning
    K Sugiyama
    Department of Neurosurgery, Hiroshima University Medical Hospital, Japan
    Brain Tumor Pathol 18:115-22. 2001
    Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP)...
  16. ncbi Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..Recently, we have identified the expression of both MMP-2 and MMP-9 in primary cultures of human giant cell tumor (GCT) of bone in vitro, and in tissue extracts in vivo. Interestingly, MMP-9 is not secreted by late-passaged GCT cells...
  17. ncbi Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody ..
  18. ncbi False-positive 1-hour glucose challenge test and adverse perinatal outcomes
    David M Stamilio
    Center for Clinical Epidemiology and Biostatistics and Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 103:148-56. 2004
    To determine whether a false-positive 1-hour glucose challenge test (GCT) is associated with perinatal complications.
  19. ncbi Can adiponectin predict gestational diabetes?
    Sawaek Weerakiet
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Gynecol Endocrinol 22:362-8. 2006
    ..and number of fetuses by ultrasound, all women underwent a 1-h glucose challenge test with 50 g glucose load (50-g GCT) between 21 and 27 weeks of GA...
  20. ncbi False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)--an update
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 43:516-21. 2003
    ..neoplasia (TIN; or carcinoma in situ of the testis) is the precursor of testicular germ-cell tumours (GCT). It is detected by conventional surgical biopsy of the testis...
  21. ncbi Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
    ....
  22. doi Stereotactic radiosurgery for pineal and related tumors
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Prog Neurol Surg 23:106-18. 2009
    ..The mean treatment volume was 3.3 ml (range 0.1-22 ml) in GCT cases and 3.7 ml (range 0.3-23 ml) in PPT cases. Prescribed doses around 50% isodose line ranged from 9.9 to 25...
  23. ncbi Effects of electrohydraulic extracorporeal shock wave lithotripsy on submandibular gland in the rat: electron microscopic evaluation
    Nuray Bayar
    Kirikkale University, Faculty of Medicine, ENT Department, Kirikkale, Turkey
    Int J Pediatr Otorhinolaryngol 63:223-33. 2002
    ..The aim of this experimental study is to investigate the local effects of electrohydraulic ESWL applied to the right submandibular gland of the rats...
  24. ncbi Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    J Interferon Cytokine Res 19:1207-17. 1999
    Giant cell tumor (GCT) of bone is a progressive, potentially malignant process that destroys skeletal tissue...
  25. ncbi Giant cell tumor of bone: a model for the in vitro human osteoclast characterization
    M Campanacci
    Centro Interdipartimentale di Ricerche sul Cancro, Giorgio Prodi, , Italy
    Tumori 75:389-95. 1989
    The in vitro growth pattern of cells obtained from bioptic material of ten patients with giant cell tumor of bone (GCT) was investigated...
  26. doi Silencing of the UCHL1 gene in giant cell tumors of bone
    Jorg Fellenberg
    Department of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 127:1804-12. 2010
    ..cells develop from mesenchymal stem cells (MSCs) but little is known about the molecular mechanisms involved in GCT tumorigenesis...
  27. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal ..
  28. ncbi Use of fluorodeoxyglucose positron emission tomography scans in patients with advanced germ cell tumour following chemotherapy: single-centre experience with long-term follow up
    C S Karapetis
    Department of Medical Oncology, Guy s Hospital, London, United Kingdom
    Intern Med J 33:427-35. 2003
    ..emission tomography (FDG-PET) may detect residual or recurrent malignancy in patients with germ cell tumours (GCT) following chemotherapy...
  29. doi The epidemiology of ovarian granulosa cell tumors: a case-control study
    E A Boyce
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, USA
    Gynecol Oncol 115:221-5. 2009
    This study identified risk factors for ovarian granulosa cell tumors (GCT) through a case-control study comparing women with GCT to women with epithelial ovarian cancers (OC) and general population (GP) controls.
  30. ncbi Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection
    Natale Alfredo Santagati
    Dipartimento di Scienze Farmaceutiche, Università di Catania Viale A Doria 6, 95125 Catania, Italy
    J Chromatogr Sci 46:150-6. 2008
    ..for the simultaneous analysis of five major catechins: (+)-catechin (C), (-)-epicatechin (EC), (-)-gallocatechin (GCT), (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCG), and the phenolic plant metabolites gallic acid (..
  31. pmc The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004)
    Jennifer L Beebe-Dimmer
    Karmanos Cancer Institute and Wayne State University Department of Internal Medicine, Detroit, MI
    Rare Tumors 1:e52. 2009
    Malignant giant cell tumor (GCT) of bone is a rare tumor with debilitating consequences...
  32. ncbi Relationship between binuclear and multinuclear cells in giant cell tumor of bone
    K Kusuzaki
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 20:2463-7. 2000
    Giant cell tumor of bone (GCT) consists of stromal and multinuclear type tumor cells...
  33. doi Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment
    Yukihiko Sonoda
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Neurosurg Pediatr 2:118-24. 2008
    ..The authors investigated factors related to the diagnosis of these lesions as well as outcome in order to help decrease the time to diagnosis and improve treatment efficacy...
  34. ncbi Regular expression of osteopontin in granular cell tumor: distinctive feature among Schwannian cell tumors
    Nobuo Hoshi
    Department of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pathol Int 55:484-90. 2005
    For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors...
  35. ncbi Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors
    Changning Wang
    Key Laboratory of Oral Biomedical Engineering, Ministry of Education of China, Wuhan University, Wuhan 430079, P R China
    Oncol Rep 15:589-94. 2006
    Cherubism (CBM) and central giant cell granuloma (CGCG) of the jaw and giant cell tumor (GCT) of the long bone are clinically different diseases. Histologically, they are all multinucleated giant cell (MGC)-containing lesions...
  36. doi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
    ..aim of this study was to relate the incidence of testicular germ cell neoplastic lesions (overt germ cell tumours--GCT or testicular carcinoma in situ) to the intensity of testicular organogenesis disturbances (dysgenesis)...
  37. ncbi Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    S M Kumta
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
    Life Sci 73:1427-36. 2003
    ..of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
  38. ncbi Granulosa cell tumor of the ovary
    Susan Tinsley Schumer
    Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 21:1180-9. 2003
    Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen...
  39. ncbi Granular cell tumor of the penis shaft: case report and literature review
    A Dema
    Department of Pathology, University of Medicine and Pharmacy V Babes, Timisoara, Romania
    Chirurgia (Bucur) 104:359-62. 2009
    Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now.
  40. ncbi Identification of markers of possible prognostic value in 57 giant cell tumors of bone
    Gabriella Gamberi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, I 40136 Bologna, Italy
    Oncol Rep 10:351-6. 2003
    Giant cell tumor of bone (GCT) is a neoplasm characterized by the presence of large numbers of multinucleated osteoclast-like giant cells, together with mononuclear spindle-shaped cells...
  41. pmc Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report
    Ran Hong
    Department of Pathology, Chosun University School of Medicine, Gwangju 501 140, South Korea
    World J Gastroenterol 15:3315-8. 2009
    A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin...
  42. ncbi Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration
    M H Zheng
    Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Australia
    J Cell Biochem 70:121-9. 1998
    Giant cell tumor of bone (GCT) is one of a few neoplasms in which the macrophage/osteoclast precursor cells and osteoclast-like giant cells infiltrate the tumor mass...
  43. ncbi Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours
    H Herbst
    Institut fur Pathologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Virchows Arch 434:11-5. 1999
    ..abnormal or dysgenetic gonads, often transforming to invasive seminomatous and nonseminomatous germ cell tumours (GCT)...
  44. doi Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites
    Harpreet Kaur
    Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Int J Clin Oncol 14:78-81. 2009
    Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade...
  45. ncbi Analysis of oral glucose tolerance test in pregnant women with abnormal glucose metabolism
    Hui Xia Yang
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 118:995-9. 2005
    ..tolerance (GIGT) and to evaluate the effect of omission of the third-hour plasma glucose (PG) level in OGTT on the sensitivity of diagnosing GDM and GIGT, and the relationship between PG values of 50 g GCT or OGTT and insulin therapy.
  46. ncbi MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India
    C B Sanjeevi
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 958:341-4. 2002
    ..Sequence determination of the MIC-A gene identifies trinucleotide repeat (GCT) microsatellite polymorphism in exon 5...
  47. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    ..Serum RBP4 concentrations at glucose challenge test (GCT) were significantly higher in the GDM group (42.4 +/- 13.8 ng/mL) than in the healthy control group (32.0 +/- 8...
  48. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  49. ncbi Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation
    Brian H Le
    Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA
    Arch Pathol Lab Med 128:771-5. 2004
    Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue...
  50. ncbi Inhibin-activin receptor subunit gene expression in ovarian tumors
    Peter J Fuller
    Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 87:1395-401. 2002
    Granulosa cell tumors of the ovary (GCT) express the inhibin subunit genes and secrete dimeric inhibin. Transgenic mice null for the alpha-inhibin gene develop GCT...
  51. ncbi A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry
    Rainer Lynen
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Transfusion 42:612-8. 2002
    Novel gel centrifugation test (GCT) cards were evaluated with respect to their ability to estimate the quantity of IgG on RBCs and the determination of the IgG subclasses IgG1 and IgG3.
  52. doi [Germ-cell tumors of the central nervous system in childhood: retrospective study of 13 patients]
    J Voirin
    Service de Neurochirurgie, Departement de Neurochirurgie, bâtiment neurologique, Hopital Central, CHU de Nancy, 29, Avenue du Marechal de Lattre de Tassigny, C O n 34, 54035 Nancy Cedex, France
    Neurochirurgie 54:55-62. 2008
    Germ cell tumors (GCT) of the central nervous system are rare (2% of all brain tumors in children)...
  53. ncbi A population-based risk factor scoring will decrease unnecessary testing for the diagnosis of gestational diabetes mellitus
    Eray Caliskan
    SSK Ankara Maternity and Women s Health Teaching Hospital, Etlik, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:524-30. 2004
    ..To determine the effectiveness of a population-based risk factor scoring to decrease unnecessary testing for the diagnosis of gestational diabetes mellitus (GDM)...
  54. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    Of all malignancies diagnosed in men between 17 and 45 years of age, 60% are germ cell tumors (GCT). GCT arise from carcinoma in situ cells, which are thought to originate from a transformed fetal germ cell, the gonocyte...
  55. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..derived from various cyanobacteria genomes, we designated the seven putative TPx members as VCP, VCT, TCS, and GCT clusters according to the sequence of their conserved catalytic motif...
  56. pmc Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
    Rachell E Booth
    Department of Chemistry and Biochemistry, Texas State University San Marcos, San Marcos, TX 78666, USA
    BMC Biol 2:2. 2004
    b>Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases...
  57. ncbi [Diagnostic of gestational diabetes mellitus and the prevalence of LGA (Large for Gestational Age)]
    Monika Szymanska
    I Katedra i Klinika Połoznictwa i Ginekologii w Warszawie
    Ginekol Pol 79:177-81. 2008
    ..The aim of the study was to examine the influence of time and diagnostic method of GDM on the prevalence of LGA and pregnancy outcome among patients with gestational diabetes...
  58. doi Small fetal abdominal circumference in the second trimester and subsequent low maternal plasma glucose after a glucose challenge test is associated with the delivery of a small-for-gestational age neonate
    J L Bienstock
    Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 31:517-9. 2008
    To evaluate the predictive value of a combination of the 1 h 50-g glucose challenge test (GCT) and second-trimester ultrasound measurement of fetal abdominal circumference (AC) in identifying patients who will go on to deliver small-for-..
  59. ncbi Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..was to determine the characteristics and clinical usefulness of 201Tl scintigraphy in giant-cell tumour of bone (GCT)...
  60. ncbi Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique
    G Battaglia
    Istituto Oncologico Veneto IOV, via Giogtinian 12, Padova, 35100, Italy
    Surg Endosc 20:1296-8. 2006
    ..The single-band mucosectomy technique was used to remove a granular cell tumor (GCT) of the esophagus. Only 3% of GCTs, which are relatively uncommon neoplasms, arise in the esophagus...
  61. doi Colorectal granular cell tumor: a clinicopathologic study of 26 cases
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1186-92. 2010
    Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA)...
  62. ncbi Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..Consecutive Japanese women with singleton pregnancies underwent a standard 1h, 50g oral glucose challenge test (GCT) at 24-27 weeks of gestation, followed by a 75g, 2h oral glucose tolerance test (OGTT) if the GCT result exceeded ..
  63. pmc Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
    Hsei Wei Wang
    School of Life Sciences, Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    BMC Genomics 11:132. 2010
    ..The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlying the differences in incidence and prognosis of the various GCT subgroups are unclear.
  64. ncbi Importance of angulate bodies in the diagnosis of granular cell tumors (schwannomas)
    P H Carstens
    Department of Pathology, University of Louisville School of Medicine, Kentucky 40292
    Ultrastruct Pathol 17:271-8. 1993
    ..ABs appear to have been forgotten, and the diagnosis of GCT currently depends solely upon the presence of large lysosomes...
  65. ncbi Testicular microlithiasis: clinical significance and review of the literature
    Bohyun Kim
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, IlWon Dong, Kangnam Ku, 135 710 Seoul, Korea bhkim smc samsung co kr
    Eur Radiol 13:2567-76. 2003
    ..6 to 9%. The TM is often associated with germ cell tumor (GCT) or intratubular germ cell neoplasia. The incidence of GCT in patients with TM was reported as 6-46%...
  66. ncbi Mechanisms underlying the structural alterations of the rat submandibular gland induced by Tityus serrulatus tityustoxin
    G T Clemente
    Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, P O Box 486, 30161 970 Belo Horizonte MG, Brazil
    Toxicon 40:731-8. 2002
    ..stimulatory effects of the toxin are observed in the secretory cells of the acini and granular convoluted tubules (GCT)...
  67. ncbi Gastric carcinoid tumors without autoimmune gastritis in Japan: a relationship with Helicobacter pylori infection
    Yuichi Sato
    Third Department of Internal Medicine, Faculty of Health Science, Niigata University School of Medicine, Japan
    Dig Dis Sci 47:579-85. 2002
    In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated with either autoimmune gastritis (AIG) showing type-A chronic atrophic gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES)...
  68. doi The performance of the screening test for gestational diabetes in twin versus singleton pregnancies
    Yariv Yogev
    Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Matern Fetal Neonatal Med 27:57-61. 2014
    Abstract Objective: To compare the performance of the 50 g glucose challenge test (GCT) and the 100 g oral glucose tolerance test (OGTT) in twin versus singleton pregnancies...
  69. ncbi Developmental and androgenic regulation of the immunocytochemical distribution of mK1, a true tissue kallikrein, in the granular convoluted tubule of the mouse submandibular gland
    Shingo Kurabuchi
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
    J Histochem Cytochem 50:135-45. 2002
    ..In both sexes at 3 weeks of age, essentially all of the immature granular convoluted tubule (GCT) cells were uniformly immunostained...
  70. ncbi Germ cell tumor in duodenum
    Mehmet Kucukoner
    Dicle University Faculty of Medicine, Department of Surgery, Diyarbakir, Turkey
    Turk J Gastroenterol 24:73-4. 2013
    Gastrointestinal system (GIS) germ cell tumors (GCT) are very uncommon. Primary duodenum germ cell tumors have rarely been reported in the literature (1, 2)...
  71. doi Management of brain metastases from germ cell tumors: a single center experience
    H J Boyle
    Department of Medical Oncology, Centre Leon Berard, Lyon, France
    Oncology 85:21-6. 2013
    Brain metastases from germ cell tumors (GCT) are rare and treatment has not yet been standardized.
  72. doi Giant cell tumours of the small bones of the hands and feet: long-term results of 30 patients and a systematic literature review
    V C Oliveira
    Centro Hospitalar do Porto Hospital Santo Antonio, Department of Orthopaedic Surgery, Largo Prof Abel Salazar, 4099 001 Porto, Portugal
    Bone Joint J 95:838-45. 2013
    ..performed a systematic review, initially screening 775 titles, and included 12 papers comprising 91 patients with GCT of the small bones of the hands and feet...
  73. doi Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis
    Sophine B Krintel
    DANBIO Registry and Department of Rheumatology, Hvidovre and Glostrup Hospitals, Glostrup, Denmark
    Pharmacogenet Genomics 22:577-89. 2012
    ..We aimed to replicate these results and identify SNPs and the possible biological pathways associated with the treatment response to TNFα inhibitors...
  74. pmc Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways
    Cheng Wang
    Department of Obstetrics and Gynecology, Olson Center for Women s Health, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e48299. 2012
    ..These tumors have malignant potential and often recur. The etiology of GCT is unknown. TGFα is a potent mitogen for many different cells...
  75. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
    Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells...
  76. doi Molecular pathogenesis of granulosa cell tumors of the ovary
    Stacey Jamieson
    Prince Henry s Institute of Medical Research and Department of Medicine, Monash University, Clayton 3168, Australia
    Endocr Rev 33:109-44. 2012
    Granulosa cell tumors of the ovary (GCT) comprise a distinct subset of ovarian cancers that account for approximately 5% of all ovarian malignancies...
  77. pmc The multifaceted granulosa cell tumours-myths and realities: a review
    Rani Kanthan
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W8 Department of Pathology and Laboratory Medicine, Royal University Hospital, 103 Hospital Drive, Room 2868, G Wing, Saskatoon, SK, Canada S7N 0W8
    ISRN Obstet Gynecol 2012:878635. 2012
    ..Design. 5 unusual presentations of GCT and a retrospective 14-year (1997-2011) surgical pathology review based on patient sex, age, tumour type and ..
  78. ncbi [High dose chemotherapy with autologous stem-cell support in germ cell tumors: The Instituto Português de Oncologia de Lisboa Francisco Gentil Series]
    Margarida Brito
    Servico de Oncologia Medica, Centro de Transplantação, Instituto Portugues de Oncologia Francisco Gentil, Lisboa, Portugal
    Acta Med Port 24:533-44. 2011
    ..stem cell transplantation (HDCT-ASCT) has been administered to patients with high-risk germ cell tumours (GCT)...
  79. doi Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis
    Isabella W Y Mak
    Department of Oncology, McMaster University, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1976-91. 2012
    Giant cell tumor of bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates, and metastatic potential...
  80. doi Hepatic metastasectomy for testicular germ cell tumors: is it worth it?
    Y Nancy You
    Division of General and Gastroenterologic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    J Gastrointest Surg 13:595-601. 2009
    Chemotherapy is highly effective for metastatic germ cell tumor (GCT), but experience with resection of hepatic metastases from GCT is limited.
  81. pmc Spontaneous transformation of human granulosa cell tumours into an aggressive phenotype: a metastasis model cell line
    Misa Imai
    Division of Reproductive Medicine, Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Tokyo 157 8535, Japan
    BMC Cancer 8:319. 2008
    ..of normal granulosa cells have been studied extensively, little is known about the molecular mechanism of GCT progression...
  82. ncbi [Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis]
    Si min Luo
    Department of Emergency Medicine, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:156-9. 2009
    To investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.
  83. pmc The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
    Holger Cynis
    Probiodrug AG, Halle, Germany
    EMBO Mol Med 3:545-58. 2011
    ..Here, we show that the N-terminal pE-formation depends on glutaminyl cyclase activity...
  84. pmc Clinical outcome and predictors of survival in late relapse of germ cell tumor
    David S Sharp
    Department of Urology, Memorial Sloan Kettering Cancer Center, 353 E 68th St, New York, NY 10021, USA
    J Clin Oncol 26:5524-9. 2008
    Late relapse (LR) of germ cell tumor (GCT) is a well recognized entity associated with poor survival. We report on our experience with LR and determine predictors of survival.
  85. ncbi Screening for gestational diabetes mellitus in Nigerian pregnant women using fifty-gram oral glucose challenge test
    O Adegbola
    Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos Lagos University Teaching Hospital, Nigeria
    West Afr J Med 27:139-43. 2008
    ..Gestational Diabetes Mellitus (GDM) is frequently associated with adverse pregnancy outcome if not adequately managed. Prompt identification of these women requires a programme of active screening...
  86. doi A risk score for selective screening for gestational diabetes mellitus
    Chadakarn Phaloprakarn
    Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Dusit district, Bangkok, Thailand
    Eur J Obstet Gynecol Reprod Biol 145:71-5. 2009
    To develop a risk score to predict women who are likely to have an abnormal glucose challenge test (GCT) for gestational diabetes mellitus (GDM) screening.
  87. ncbi Using the 100-g oral glucose tolerance test to predict fetal and maternal outcomes in women with gestational diabetes mellitus
    Chia Hung Lin
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:283-9. 2009
    ..This 5-year cohort study investigated gestational diabetes mellitus (GDM) using new diagnostic criteria and predictive factors for maternal and fetal outcomes...
  88. ncbi Expression of bone morphogenetic proteins in giant cell tumor of bone
    Naoko Kudo
    Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
    Anticancer Res 29:2219-25. 2009
    A giant cell tumor (GCT) of bone is a locally aggressive tumor with a propensity for local recurrence...
  89. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
    Giant Cell Tumor of Bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates and metastatic potential...
  90. doi Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation
    Yoshiharu Hiruma
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo 134 8630, Japan
    Biochem Biophys Res Commun 409:424-9. 2011
    ..In giant cell tumor of bone (GCT), numerous TRAP-positive multinucleated giant cells emerge and severe osteolytic bone destruction occurs, implying ..
  91. doi Criteria for screening and diagnosis of gestational diabetes mellitus in the first trimester of pregnancy
    Walter Plasencia
    Hospital Universitario Materno Infantil de Canarias, Las Palmas, Spain
    Fetal Diagn Ther 30:108-15. 2011
    ..To propose new cutoffs in plasma glucose levels in screening and diagnosis of gestational diabetes mellitus (GDM) in the first trimester of pregnancy...
  92. ncbi Expression of histone deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours
    Florian R Fritzsche
    Institute of Surgical Pathology, University Hospital Zurich, Switzerland
    Histol Histopathol 26:1555-61. 2011
    ..we aimed to evaluate the protein expression of class I histone deacetylases (HDAC) in testicular germ cell tumours (GCT) and to analyse differences between the histological subtypes of testicular GCT...
  93. pmc Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature
    Christopher Martin
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Iowa Orthop J 30:69-75. 2010
    Although there have been a few large case series of giant cell tumor (GCT) in the spine and sacrum, the treatment of these lesions remains controversial...
  94. ncbi Hepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepatocyte-derived cells
    Tohru Ikeda
    Department of Pathology and Immunology, Aging and Developmental Science, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Pathol Int 53:450-6. 2003
    Giant cell tumor (GCT) of bone is a primary osteolytic tumor that is characterized by the formation of osteoclast-like giant cells. In addition to GCT of bone, extraskeletal GCT are known to be formed in several soft tissues...
  95. doi Histologically confirmed intracranial germ cell tumors; an analysis of 62 patients in a single institute
    Dakeun Lee
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam Gu, Seoul 135 710, Republic of Korea
    Virchows Arch 457:347-57. 2010
    ..The records of 62 patients (45 males and 17 females) with a primary intracranial GCT were retrospectively analyzed. Mean patient age was 18 years, and median follow-up was 41 months...
  96. doi FN1, GALE, MET, and QPCT overexpression in papillary thyroid carcinoma: molecular analysis using frozen tissue and routine fine-needle aspiration biopsy samples
    Cristina Aparecida Troques da Silveira Mitteldorf
    Laboratory of Surgical and Molecular Pathology, Hospital Sirio Libanes, Rua Dona Adma Jafet 91, 01308 050 São Paulo, Brazil
    Diagn Cytopathol 39:556-61. 2011
    ....
  97. doi Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center
    Bharat Rekhi
    Department of Pathology, Tata Memorial Hospital, Mumbai, India
    Ann Diagn Pathol 14:162-7. 2010
    A granular cell tumor (GCT) is relatively uncommon and objectively diagnosed with neural markers on immunohistochemistry (IHC). Recent studies have described additional markers for a GCT...
  98. doi Expression of cAMP response element-binding protein in the duct system of the mouse submandibular gland
    Sunisa Keattikunpairoj
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8640, Japan
    Histochem Cell Biol 132:647-57. 2009
    ..gland (SMG) of mice shows a marked sexual dimorphism in which a duct portion called the granular convoluted tubule (GCT) is developed preferentially in males during puberty...
  99. pmc Pediatric germ cell tumors and maternal vitamin supplementation: a Children's Oncology Group study
    Kimberly J Johnson
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 18:2661-4. 2009
    ..We examined this relationship in a study of childhood germ cell tumors (GCT)...
  100. doi Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of ovary and other human cancers
    Min Sung Kim
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Pathol 221:147-52. 2010
    ..somatic mutation in the FOXL2 gene affecting codon 134 has recently been reported in granulosa cell tumour (GCT) and thecoma of the ovary...
  101. doi The clinical utility of oral glucose tolerance test at term: can it predict fetal macrosomia?
    Ossie Geifman-Holtzman
    Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Temple University Hospital, Temple University, 3401 N Broad St, Philadelphia, PA 19140, USA
    Arch Gynecol Obstet 281:817-21. 2010
    The goal of this study was to assess the correlation between true fetal macrosomia and abnormal oral glucose tolerance test (OGTT) in pregnant women at term gestation who had a negative glucose challenge screen (GCT) at 24-28 weeks.

Research Grants65

  1. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2011
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  2. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2010
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  3. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2007
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  4. Cyclin D as a Retinoid Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2007
    This revised new NIH R01 application evaluates cyclin D1 as a molecular target for germ cell tumor (GCT) growth, maturation, and chemotherapy response...
  5. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  6. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  7. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  8. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  9. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  10. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2007
    ..The Training Program is based in the Graduate Center for Toxicology (GCT) which grants the Ph.D. in Toxicology, and provides an administrative and teaching nucleus of 6 core faculty...
  11. SOUTHWEST ONCOLOGY GROUP
    Heinz Josef Lenz; Fiscal Year: 2007
    ..b>GCT bladder CA trial; NCI UO-1 funded pharmacology and molecular prediction of outcome studies in phase II geriatric ..