glutaminyl cyclase

Summary

Gene Symbol: glutaminyl cyclase
Description: glutaminyl-peptide cyclotransferase
Alias: GCT, sQC, glutaminyl cyclase, glutaminyl-tRNA cyclotransferase, glutamyl cyclase
Species: human

Top Publications

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
  4. ncbi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
  5. ncbi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
  9. ncbi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000

Detail Information

Publications156 found, 100 shown here

  1. ncbi Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y)
    K Sawada
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Acta Anat (Basel) 143:241-5. 1992
    ..In either 30- or 90-day-old wild-type male mice, the granular convoluted tubules (GCT) of the glands were more developed, and the relative occupied areas (ROA) of GCT were superior to those of the age-..
  2. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    b>Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer's disease (AD) Abeta peptides in vivo...
  3. doi CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression
    Patrick Kwok Shing Ng
    School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
    J Cell Biochem 110:438-46. 2010
    Giant cell tumor (GCT) of bone is an aggressive non-cancerous tumor, which consists of multi-nucleated osteoclast-like giant cells, stromal cells, and monocytes...
  4. ncbi Evaluation of fasting and random plasma glucose for diagnosis of gestational diabetes
    Sikandar Hayat Khan
    Department of Pathology, PNS Rahat Hospital, Karachi
    J Coll Physicians Surg Pak 19:718-22. 2009
    To compare different cut-off values of fasting and random plasma glucose as a screening test for diagnosis of gestational diabetes in comparison to the 50 grams Glucose Challenge Test (GCT).
  5. ncbi Less advanced testicular dysgenesis is associated by a higher prevalence of germ cell neoplasia
    A Guminska
    Division of Reproductive Endocrinology, Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
    Int J Androl 33:e153-62. 2010
    ..aim of this study was to relate the incidence of testicular germ cell neoplastic lesions (overt germ cell tumours--GCT or testicular carcinoma in situ) to the intensity of testicular organogenesis disturbances (dysgenesis)...
  6. ncbi An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
    W H Busby
    J Biol Chem 262:8532-6. 1987
    ..These findings indicate that in vivo the post-translational conversion of a glutaminyl-peptide into a pyroglutamyl-peptide is neither spontaneous nor abiotic as has been previously proposed...
  7. ncbi Glutaconate CoA-transferase from Acidaminococcus fermentans: the crystal structure reveals homology with other CoA-transferases
    U Jacob
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    Structure 5:415-26. 1997
    ..We describe here the crystal structure of glutaconate CoA-transferase (GCT) from the strictly anaerobic bacterium Acidaminococcus fermentans...
  8. ncbi Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?
    J Shamash
    Department of Medical Oncology, School of Medicine and Dentistry, St Bartholomew s and Royal London Hospitals, Queen Mary and Westfield College, Smithfield, UK
    Acta Oncol 39:857-63. 2000
    Thirty consecutive patients with relapsing germ cell tumours (GCT) were treated with induction chemotherapy and high-dose chemotherapy consolidation (HDCT)...
  9. ncbi Long bones giant cells tumors: treatment by curretage and cavity filling cementation
    N Fraquet
    Bone and Joint Unit, Hôtel Dieu Teaching Medical Center, Place A Ricordeau, 44093 Nantes Cedex, France
    Orthop Traumatol Surg Res 95:402-6. 2009
    Giant cell tumors (GCT) of bone are benign tumors with local aggressiveness that most of the time occur around the metaphyseal area of long bones, often in contact with the articular cartilage...
  10. ncbi Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients
    R J Motzer
    Genitourinary Oncology, Nuclear Medicine, and Renal Services, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 18:1173-80. 2000
    ..administered plus peripheral blood-derived stem-cell (PBSC) support for patients with germ cell tumors (GCT) who have unfavorable prognostic features in response to conventional-dose salvage programs...
  11. ncbi [Pregnant outcomes and neonatal anthropometry in women with abnormal glucose challenge test and normal oral glucose tolerance test during pregnancy.]
    Hai Tian Chen
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Fu Chan Ke Za Zhi 44:801-4. 2009
    To evaluate the influences of abnormal glucose challenge test(GCT) on pregnancy outcomes and neonatal anthropometric data in women with normal oral glucose tolerance test(OGTT).
  12. ncbi Giant cell tumor of the cervical spine: a series of 22 cases and outcomes
    Ma Junming
    The Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 33:280-8. 2008
    ..A consecutive series of 22 giant cell tumor (GCTs) of the cervical spine which underwent surgical treatment was observed from 1990-2003...
  13. ncbi Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor
    Madhu Mazumdar
    Memorial Sloan Kettering Cancer Center, 307 E 63rd St, 3rd Floor, New York, NY 10021, USA
    J Clin Oncol 21:2679-88. 2003
    ..information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation...
  14. ncbi Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning
    K Sugiyama
    Department of Neurosurgery, Hiroshima University Medical Hospital, Japan
    Brain Tumor Pathol 18:115-22. 2001
    Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP)...
  15. ncbi Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidases
    J Pedersen
    UNIZYME Laboratories, Dr Neergaards vej 17, Horsholm, DK 2970, Denmark
    Protein Expr Purif 15:389-400. 1999
    ..the aminopeptidase dipeptidyl peptidase I (DPPI), either alone or in combination with glutamine cyclotransferase (GCT) and pyroglutamyl aminopeptidase (PGAP)...
  16. ncbi Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
    Clin Exp Metastasis 15:400-9. 1997
    ..Recently, we have identified the expression of both MMP-2 and MMP-9 in primary cultures of human giant cell tumor (GCT) of bone in vitro, and in tissue extracts in vivo. Interestingly, MMP-9 is not secreted by late-passaged GCT cells...
  17. pmc Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and localization of a true tissue kallikrein, mK1, in the mouse submandibular gland
    Shingo Kurabuchi
    Dept of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1 9 20, Chiyoda ku, Tokyo 102 8159, Japan
    J Histochem Cytochem 52:1437-46. 2004
    ..T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody ..
  18. ncbi False-positive 1-hour glucose challenge test and adverse perinatal outcomes
    David M Stamilio
    Center for Clinical Epidemiology and Biostatistics and Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Obstet Gynecol 103:148-56. 2004
    To determine whether a false-positive 1-hour glucose challenge test (GCT) is associated with perinatal complications.
  19. ncbi Can adiponectin predict gestational diabetes?
    Sawaek Weerakiet
    Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Gynecol Endocrinol 22:362-8. 2006
    ..and number of fetuses by ultrasound, all women underwent a 1-h glucose challenge test with 50 g glucose load (50-g GCT) between 21 and 27 weeks of GA...
  20. ncbi Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
    ....
  21. ncbi False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN)--an update
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 43:516-21. 2003
    ..neoplasia (TIN; or carcinoma in situ of the testis) is the precursor of testicular germ-cell tumours (GCT). It is detected by conventional surgical biopsy of the testis...
  22. ncbi Effects of electrohydraulic extracorporeal shock wave lithotripsy on submandibular gland in the rat: electron microscopic evaluation
    Nuray Bayar
    Kirikkale University, Faculty of Medicine, ENT Department, Kirikkale, Turkey
    Int J Pediatr Otorhinolaryngol 63:223-33. 2002
    ..The aim of this experimental study is to investigate the local effects of electrohydraulic ESWL applied to the right submandibular gland of the rats...
  23. doi Stereotactic radiosurgery for pineal and related tumors
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Prog Neurol Surg 23:106-18. 2009
    ..The mean treatment volume was 3.3 ml (range 0.1-22 ml) in GCT cases and 3.7 ml (range 0.3-23 ml) in PPT cases. Prescribed doses around 50% isodose line ranged from 9.9 to 25...
  24. ncbi Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone
    V H Rao
    Center for Human Molecular Genetics, Munroe Meyer Institute for Genetics and Rehabilitation, and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    J Interferon Cytokine Res 19:1207-17. 1999
    Giant cell tumor (GCT) of bone is a progressive, potentially malignant process that destroys skeletal tissue...
  25. ncbi Giant cell tumor of bone: a model for the in vitro human osteoclast characterization
    M Campanacci
    Centro Interdipartimentale di Ricerche sul Cancro, Giorgio Prodi, , Italy
    Tumori 75:389-95. 1989
    The in vitro growth pattern of cells obtained from bioptic material of ten patients with giant cell tumor of bone (GCT) was investigated...
  26. doi Silencing of the UCHL1 gene in giant cell tumors of bone
    Jorg Fellenberg
    Department of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 127:1804-12. 2010
    ..cells develop from mesenchymal stem cells (MSCs) but little is known about the molecular mechanisms involved in GCT tumorigenesis...
  27. ncbi Use of fluorodeoxyglucose positron emission tomography scans in patients with advanced germ cell tumour following chemotherapy: single-centre experience with long-term follow up
    C S Karapetis
    Department of Medical Oncology, Guy s Hospital, London, United Kingdom
    Intern Med J 33:427-35. 2003
    ..emission tomography (FDG-PET) may detect residual or recurrent malignancy in patients with germ cell tumours (GCT) following chemotherapy...
  28. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal ..
  29. ncbi The epidemiology of ovarian granulosa cell tumors: a case-control study
    E A Boyce
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women s Hospital, USA
    Gynecol Oncol 115:221-5. 2009
    This study identified risk factors for ovarian granulosa cell tumors (GCT) through a case-control study comparing women with GCT to women with epithelial ovarian cancers (OC) and general population (GP) controls.
  30. ncbi Simultaneous determination of catechins, rutin, and gallic acid in Cistus species extracts by HPLC with diode array detection
    Natale Alfredo Santagati
    Dipartimento di Scienze Farmaceutiche, Università di Catania Viale A Doria 6, 95125 Catania, Italy
    J Chromatogr Sci 46:150-6. 2008
    ..for the simultaneous analysis of five major catechins: (+)-catechin (C), (-)-epicatechin (EC), (-)-gallocatechin (GCT), (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCG), and the phenolic plant metabolites gallic acid (..
  31. pmc The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004)
    Jennifer L Beebe-Dimmer
    Karmanos Cancer Institute and Wayne State University Department of Internal Medicine, Detroit, MI
    Rare Tumors 1:e52. 2009
    Malignant giant cell tumor (GCT) of bone is a rare tumor with debilitating consequences...
  32. ncbi Relationship between binuclear and multinuclear cells in giant cell tumor of bone
    K Kusuzaki
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 20:2463-7. 2000
    Giant cell tumor of bone (GCT) consists of stromal and multinuclear type tumor cells...
  33. ncbi Germ cell tumors in the basal ganglia: problems of early diagnosis and treatment
    Yukihiko Sonoda
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Neurosurg Pediatr 2:118-24. 2008
    ..The authors investigated factors related to the diagnosis of these lesions as well as outcome in order to help decrease the time to diagnosis and improve treatment efficacy...
  34. ncbi Regular expression of osteopontin in granular cell tumor: distinctive feature among Schwannian cell tumors
    Nobuo Hoshi
    Department of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pathol Int 55:484-90. 2005
    For further characterization of S-100 protein-positive granular cell tumor (GCT), the expression of osteopontin (OPN) in the tumor cells was compared with other types of Schwannian cell tumors...
  35. ncbi Granulosa cell tumor of the ovary
    Susan Tinsley Schumer
    Program in Gynecologic Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Oncol 21:1180-9. 2003
    Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen...
  36. ncbi Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions
    S M Kumta
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
    Life Sci 73:1427-36. 2003
    ..of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
  37. ncbi Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors
    Changning Wang
    Key Laboratory of Oral Biomedical Engineering, Ministry of Education of China, Wuhan University, Wuhan 430079, P R China
    Oncol Rep 15:589-94. 2006
    Cherubism (CBM) and central giant cell granuloma (CGCG) of the jaw and giant cell tumor (GCT) of the long bone are clinically different diseases. Histologically, they are all multinucleated giant cell (MGC)-containing lesions...
  38. ncbi Granular cell tumor of the penis shaft: case report and literature review
    A Dema
    Department of Pathology, University of Medicine and Pharmacy V Babes, Timisoara, Romania
    Chirurgia (Bucur) 104:359-62. 2009
    Granular cell tumors (GCT) are uncommon soft tissue neoplasms of presumed neural origin that rarely involve the male external genitalia. Penile lesions are distinctly uncommon with less than 20 cases reported till now.
  39. ncbi Identification of markers of possible prognostic value in 57 giant cell tumors of bone
    Gabriella Gamberi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, I 40136 Bologna, Italy
    Oncol Rep 10:351-6. 2003
    Giant cell tumor of bone (GCT) is a neoplasm characterized by the presence of large numbers of multinucleated osteoclast-like giant cells, together with mononuclear spindle-shaped cells...
  40. pmc Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report
    Ran Hong
    Department of Pathology, Chosun University School of Medicine, Gwangju 501 140, South Korea
    World J Gastroenterol 15:3315-8. 2009
    A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin...
  41. ncbi Human endogenous retrovirus (HERV)-K transcripts in gonadoblastomas and gonadoblastoma-derived germ cell tumours
    H Herbst
    Institut fur Pathologie, Universitatskrankenhaus Eppendorf, Hamburg, Germany
    Virchows Arch 434:11-5. 1999
    ..abnormal or dysgenetic gonads, often transforming to invasive seminomatous and nonseminomatous germ cell tumours (GCT)...
  42. ncbi Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration
    M H Zheng
    Department of Orthopaedic Surgery, University of Western Australia, Nedlands, Australia
    J Cell Biochem 70:121-9. 1998
    Giant cell tumor of bone (GCT) is one of a few neoplasms in which the macrophage/osteoclast precursor cells and osteoclast-like giant cells infiltrate the tumor mass...
  43. doi Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites
    Harpreet Kaur
    Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research PGIMER, Chandigarh, India
    Int J Clin Oncol 14:78-81. 2009
    Juvenile granulosa cell tumor (GCT) is a rare tumor, and the majority (90%) are reported in the prepubertal or under-30-year age group, in contrast to the adult type, which is more common in the fifth decade...
  44. ncbi Analysis of oral glucose tolerance test in pregnant women with abnormal glucose metabolism
    Hui Xia Yang
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 118:995-9. 2005
    ..tolerance (GIGT) and to evaluate the effect of omission of the third-hour plasma glucose (PG) level in OGTT on the sensitivity of diagnosing GDM and GIGT, and the relationship between PG values of 50 g GCT or OGTT and insulin therapy.
  45. ncbi MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India
    C B Sanjeevi
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 958:341-4. 2002
    ..Sequence determination of the MIC-A gene identifies trinucleotide repeat (GCT) microsatellite polymorphism in exon 5...
  46. ncbi Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus
    Te Fu Chan
    Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital
    Reprod Sci 14:169-74. 2007
    ..Serum RBP4 concentrations at glucose challenge test (GCT) were significantly higher in the GDM group (42.4 +/- 13.8 ng/mL) than in the healthy control group (32.0 +/- 8...
  47. ncbi Inhibin-activin receptor subunit gene expression in ovarian tumors
    Peter J Fuller
    Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
    J Clin Endocrinol Metab 87:1395-401. 2002
    Granulosa cell tumors of the ovary (GCT) express the inhibin subunit genes and secrete dimeric inhibin. Transgenic mice null for the alpha-inhibin gene develop GCT...
  48. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  49. ncbi Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation
    Brian H Le
    Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA
    Arch Pathol Lab Med 128:771-5. 2004
    Granular cell tumor (GCT) is a rare tumor of nerve sheath origin with a predilection for upper aerodigestive tract, skin, and soft tissue...
  50. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    Of all malignancies diagnosed in men between 17 and 45 years of age, 60% are germ cell tumors (GCT). GCT arise from carcinoma in situ cells, which are thought to originate from a transformed fetal germ cell, the gonocyte...
  51. doi [Germ-cell tumors of the central nervous system in childhood: retrospective study of 13 patients]
    J Voirin
    Service de Neurochirurgie, Departement de Neurochirurgie, bâtiment neurologique, Hopital Central, CHU de Nancy, 29, Avenue du Marechal de Lattre de Tassigny, C O n 34, 54035 Nancy Cedex, France
    Neurochirurgie 54:55-62. 2008
    Germ cell tumors (GCT) of the central nervous system are rare (2% of all brain tumors in children)...
  52. ncbi A population-based risk factor scoring will decrease unnecessary testing for the diagnosis of gestational diabetes mellitus
    Eray Caliskan
    SSK Ankara Maternity and Women s Health Teaching Hospital, Etlik, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:524-30. 2004
    ..To determine the effectiveness of a population-based risk factor scoring to decrease unnecessary testing for the diagnosis of gestational diabetes mellitus (GDM)...
  53. ncbi Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
    Mee Kyung Cha
    Department of Biochemistry, Paichai University, 439 6 Doma 2 Dong Seo Gu, Taejon 302 735, Republic of Korea
    Free Radic Biol Med 42:1736-48. 2007
    ..derived from various cyanobacteria genomes, we designated the seven putative TPx members as VCP, VCT, TCS, and GCT clusters according to the sequence of their conserved catalytic motif...
  54. ncbi A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry
    Rainer Lynen
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Transfusion 42:612-8. 2002
    Novel gel centrifugation test (GCT) cards were evaluated with respect to their ability to estimate the quantity of IgG on RBCs and the determination of the IgG subclasses IgG1 and IgG3.
  55. pmc Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site
    Rachell E Booth
    Department of Chemistry and Biochemistry, Texas State University San Marcos, San Marcos, TX 78666, USA
    BMC Biol 2:2. 2004
    b>Glutaminyl cyclase (QC) forms the pyroglutamyl residue at the amino terminus of numerous secretory peptides and proteins. We previously proposed the mammalian QC has some features in common with zinc aminopeptidases...
  56. ncbi Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique
    G Battaglia
    Istituto Oncologico Veneto IOV, via Giogtinian 12, Padova, 35100, Italy
    Surg Endosc 20:1296-8. 2006
    ..The single-band mucosectomy technique was used to remove a granular cell tumor (GCT) of the esophagus. Only 3% of GCTs, which are relatively uncommon neoplasms, arise in the esophagus...
  57. ncbi [Diagnostic of gestational diabetes mellitus and the prevalence of LGA (Large for Gestational Age)]
    Monika Szymanska
    I Katedra i Klinika Połoznictwa i Ginekologii w Warszawie
    Ginekol Pol 79:177-81. 2008
    ..The aim of the study was to examine the influence of time and diagnostic method of GDM on the prevalence of LGA and pregnancy outcome among patients with gestational diabetes...
  58. ncbi Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..was to determine the characteristics and clinical usefulness of 201Tl scintigraphy in giant-cell tumour of bone (GCT)...
  59. ncbi Hypertensive disorders in Japanese women with gestational glucose intolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 64:201-5. 2004
    ..Consecutive Japanese women with singleton pregnancies underwent a standard 1h, 50g oral glucose challenge test (GCT) at 24-27 weeks of gestation, followed by a 75g, 2h oral glucose tolerance test (OGTT) if the GCT result exceeded ..
  60. ncbi Colorectal granular cell tumor: a clinicopathologic study of 26 cases
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1186-92. 2010
    Granular cell tumor (GCT) is commonly located in the subcutaneous tissue and oral cavity, and uncommon in the gastrointestinal tract, in which the majority arises in the esophagus with over-representation in African Americans (AA)...
  61. ncbi Small fetal abdominal circumference in the second trimester and subsequent low maternal plasma glucose after a glucose challenge test is associated with the delivery of a small-for-gestational age neonate
    J L Bienstock
    Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ultrasound Obstet Gynecol 31:517-9. 2008
    To evaluate the predictive value of a combination of the 1 h 50-g glucose challenge test (GCT) and second-trimester ultrasound measurement of fetal abdominal circumference (AC) in identifying patients who will go on to deliver small-for-..
  62. pmc Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations
    Hsei Wei Wang
    School of Life Sciences, Institute of Microbiology and Immunology, National Yang Ming University, Taipei, Taiwan
    BMC Genomics 11:132. 2010
    ..The second group of tumors requires more extensive drug and irradiation treatment regimens. The mechanisms underlying the differences in incidence and prognosis of the various GCT subgroups are unclear.
  63. ncbi Importance of angulate bodies in the diagnosis of granular cell tumors (schwannomas)
    P H Carstens
    Department of Pathology, University of Louisville School of Medicine, Kentucky 40292
    Ultrastruct Pathol 17:271-8. 1993
    ..ABs appear to have been forgotten, and the diagnosis of GCT currently depends solely upon the presence of large lysosomes...
  64. doi YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors
    David Fu
    Olson Center for Women s Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA Department of Pathology, Tianjin Medical University Cancer Hospital, Tianjin, China Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
    Endocr Relat Cancer 21:297-310. 2014
    ..Ovarian granulosa cell tumors (GCT) are characterized by enlargement of the ovary, excess production of estrogen, a high frequency of recurrence, and ..
  65. ncbi Active approach for breast cancer genetic counseling during radiotherapy: long-term psychosocial and medical impact
    J E Baars
    Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Clin Genet 85:524-31. 2014
    Genetic counseling and DNA testing (GCT) for breast cancer is increasingly being actively offered to newly diagnosed patients. Little is known about the consequences of such an approach...
  66. pmc Surrogate production of eggs and sperm by intrapapillary transplantation of germ cells in cytoablated adult fish
    Sullip Kumar Majhi
    Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato, Tokyo, Japan Division of Molecular Biology and Biotechnology, National Bureau of Fish Genetic Resources, Dilkhusa, Lucknow, India
    PLoS ONE 9:e95294. 2014
    Germ cell transplantation (GCT) is a promising assisted reproductive technology for the conservation and propagation of endangered and valuable genetic resources...
  67. ncbi Mechanisms underlying the structural alterations of the rat submandibular gland induced by Tityus serrulatus tityustoxin
    G T Clemente
    Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, P O Box 486, 30161 970 Belo Horizonte MG, Brazil
    Toxicon 40:731-8. 2002
    ..stimulatory effects of the toxin are observed in the secretory cells of the acini and granular convoluted tubules (GCT)...
  68. ncbi Testicular microlithiasis: clinical significance and review of the literature
    Bohyun Kim
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, IlWon Dong, Kangnam Ku, 135 710 Seoul, Korea bhkim smc samsung co kr
    Eur Radiol 13:2567-76. 2003
    ..6 to 9%. The TM is often associated with germ cell tumor (GCT) or intratubular germ cell neoplasia. The incidence of GCT in patients with TM was reported as 6-46%...
  69. ncbi Gastric carcinoid tumors without autoimmune gastritis in Japan: a relationship with Helicobacter pylori infection
    Yuichi Sato
    Third Department of Internal Medicine, Faculty of Health Science, Niigata University School of Medicine, Japan
    Dig Dis Sci 47:579-85. 2002
    In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated with either autoimmune gastritis (AIG) showing type-A chronic atrophic gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES)...
  70. ncbi The performance of the screening test for gestational diabetes in twin versus singleton pregnancies
    Yariv Yogev
    Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Matern Fetal Neonatal Med 27:57-61. 2014
    To compare the performance of the 50 g glucose challenge test (GCT) and the 100 g oral glucose tolerance test (OGTT) in twin versus singleton pregnancies.
  71. ncbi Developmental and androgenic regulation of the immunocytochemical distribution of mK1, a true tissue kallikrein, in the granular convoluted tubule of the mouse submandibular gland
    Shingo Kurabuchi
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York 10031, USA
    J Histochem Cytochem 50:135-45. 2002
    ..In both sexes at 3 weeks of age, essentially all of the immature granular convoluted tubule (GCT) cells were uniformly immunostained...
  72. ncbi Germ cell tumor in duodenum
    Mehmet Kucukoner
    Dicle University Faculty of Medicine, Department of Surgery, Diyarbakir, Turkey
    Turk J Gastroenterol 24:73-4. 2013
    Gastrointestinal system (GIS) germ cell tumors (GCT) are very uncommon. Primary duodenum germ cell tumors have rarely been reported in the literature (1, 2)...
  73. doi Management of brain metastases from germ cell tumors: a single center experience
    H J Boyle
    Department of Medical Oncology, Centre Leon Berard, Lyon, France
    Oncology 85:21-6. 2013
    Brain metastases from germ cell tumors (GCT) are rare and treatment has not yet been standardized.
  74. doi Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis
    Sophine B Krintel
    DANBIO Registry and Department of Rheumatology, Hvidovre and Glostrup Hospitals, Glostrup, Denmark
    Pharmacogenet Genomics 22:577-89. 2012
    ..We aimed to replicate these results and identify SNPs and the possible biological pathways associated with the treatment response to TNFα inhibitors...
  75. doi Giant cell tumours of the small bones of the hands and feet: long-term results of 30 patients and a systematic literature review
    V C Oliveira
    Centro Hospitalar do Porto Hospital Santo Antonio, Department of Orthopaedic Surgery, Largo Prof Abel Salazar, 4099 001 Porto, Portugal
    Bone Joint J 95:838-45. 2013
    ..performed a systematic review, initially screening 775 titles, and included 12 papers comprising 91 patients with GCT of the small bones of the hands and feet...
  76. ncbi Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis
    Isabella W Y Mak
    Department of Oncology, McMaster University, Hamilton, Ontario, Canada
    J Bone Miner Res 27:1976-91. 2012
    Giant cell tumor of bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates, and metastatic potential...
  77. pmc The multifaceted granulosa cell tumours-myths and realities: a review
    Rani Kanthan
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 0W8 Department of Pathology and Laboratory Medicine, Royal University Hospital, 103 Hospital Drive, Room 2868, G Wing, Saskatoon, SK, Canada S7N 0W8
    ISRN Obstet Gynecol 2012:878635. 2012
    ..Design. 5 unusual presentations of GCT and a retrospective 14-year (1997-2011) surgical pathology review based on patient sex, age, tumour type and ..
  78. pmc Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 7:e46769. 2012
    Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells...
  79. doi Molecular pathogenesis of granulosa cell tumors of the ovary
    Stacey Jamieson
    Prince Henry s Institute of Medical Research and Department of Medicine, Monash University, Clayton 3168, Australia
    Endocr Rev 33:109-44. 2012
    Granulosa cell tumors of the ovary (GCT) comprise a distinct subset of ovarian cancers that account for approximately 5% of all ovarian malignancies...
  80. ncbi [High dose chemotherapy with autologous stem-cell support in germ cell tumors: The Instituto Português de Oncologia de Lisboa Francisco Gentil Series]
    Margarida Brito
    Servico de Oncologia Medica, Centro de Transplantação, Instituto Portugues de Oncologia Francisco Gentil, Lisboa, Portugal
    Acta Med Port 24:533-44. 2011
    ..stem cell transplantation (HDCT-ASCT) has been administered to patients with high-risk germ cell tumours (GCT)...
  81. pmc Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways
    Cheng Wang
    Department of Obstetrics and Gynecology, Olson Center for Women s Health, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e48299. 2012
    ..These tumors have malignant potential and often recur. The etiology of GCT is unknown. TGFα is a potent mitogen for many different cells...
  82. ncbi Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study
    Lung Fung Tse
    Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
    Bone 42:68-73. 2008
    Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that is characterized by the presence of mononuclear stromal cells and multinucleated giant cells...
  83. ncbi Improved determination of bovine glutaminyl cyclase activity using precolumn derivatization and reversed-phase high-performance liquid chromatography with ultraviolet detection
    Toshiyuki Chikuma
    Department of Hygienic Chemistry, Showa Pharmaceutical University, 3 3165 Higashi Tamagawagakuen, Machida shi, Tokyo 194 8543, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 806:113-8. 2004
    A sensitive, rapid and reproducible assay for the determination of glutaminyl cyclase activity is reported...
  84. ncbi Expression of histone deacetylases 1, 2 and 3 in histological subtypes of testicular germ cell tumours
    Florian R Fritzsche
    Institute of Surgical Pathology, University Hospital Zurich, Switzerland
    Histol Histopathol 26:1555-61. 2011
    ..we aimed to evaluate the protein expression of class I histone deacetylases (HDAC) in testicular germ cell tumours (GCT) and to analyse differences between the histological subtypes of testicular GCT...
  85. ncbi Targeting telomerase activity by BIBR1532 as a therapeutic approach in germ cell tumors
    Sandra Mueller
    Department of Oncology, Hematology, Immunology and Rheumatology, Medical Center, University of Tuebingen, Tuebingen, Germany
    Invest New Drugs 25:519-24. 2007
    Germ cell tumors (GCT) possess a high activity of telomerase, a ribonucleoprotein complex compensating the erosion of telomeres during cell division by adding TTAGGG-repeats to the telomeric ends of chromosomes...
  86. doi Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta
    Holger Cynis
    Probiodrug AG, Weinbergweg 22, 06120 Halle Saale, Germany
    Biochemistry 47:7405-13. 2008
    ..Previous studies using artificial peptide substrates suggested the potential involvement of the enzyme glutaminyl cyclase in generation of pGlu-Abeta...
  87. ncbi Malignant germ cell tumors in childhood: results of the first Italian cooperative study "TCG 91"
    Margherita Lo Curto
    Dipartimento Materno Infantile, University of Palermo, Italy
    Med Pediatr Oncol 41:417-25. 2003
    About 20% of patients with germ cell tumor (GCT) are still resistant to therapy...
  88. pmc Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature
    Christopher Martin
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Iowa Orthop J 30:69-75. 2010
    Although there have been a few large case series of giant cell tumor (GCT) in the spine and sacrum, the treatment of these lesions remains controversial...
  89. doi Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation
    Yoshiharu Hiruma
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo 134 8630, Japan
    Biochem Biophys Res Commun 409:424-9. 2011
    ..In giant cell tumor of bone (GCT), numerous TRAP-positive multinucleated giant cells emerge and severe osteolytic bone destruction occurs, implying ..
  90. ncbi High-dose chemotherapy for male germ cell tumor
    Isao Hara
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Urol 13:1037-44. 2006
    Today, 20-30% of male patients with advanced germ cell tumor (GCT) do not have durable, complete remission in spite of cis-platinum (CDDP)-based chemotherapy. High-dose chemotherapy (HDCT) has been tried in CDDP refractory GCT patients...
  91. doi Hepatic metastasectomy for testicular germ cell tumors: is it worth it?
    Y Nancy You
    Division of General and Gastroenterologic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA
    J Gastrointest Surg 13:595-601. 2009
    Chemotherapy is highly effective for metastatic germ cell tumor (GCT), but experience with resection of hepatic metastases from GCT is limited.
  92. ncbi Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center
    Bharat Rekhi
    Department of Pathology, Tata Memorial Hospital, Mumbai, India
    Ann Diagn Pathol 14:162-7. 2010
    A granular cell tumor (GCT) is relatively uncommon and objectively diagnosed with neural markers on immunohistochemistry (IHC). Recent studies have described additional markers for a GCT...
  93. doi Criteria for screening and diagnosis of gestational diabetes mellitus in the first trimester of pregnancy
    Walter Plasencia
    Hospital Universitario Materno Infantil de Canarias, Las Palmas, Spain
    Fetal Diagn Ther 30:108-15. 2011
    ..To propose new cutoffs in plasma glucose levels in screening and diagnosis of gestational diabetes mellitus (GDM) in the first trimester of pregnancy...
  94. ncbi Binuclear cells induced by acridine orange in giant cell tumor of bone
    K Kusuzaki
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 20:3013-7. 2000
    ..found the presence of many binuclear cells among isolated and smeared cells in giant cell tumor of the bone (GCT). These binuclear cells are possibly associated with the formation of multinuclear cells...
  95. ncbi Detection of germ-cell-tumor-specific gene products in peripheral blood by immunomagnetic tumor cell enrichment followed by RT-PCR
    M Schrader
    Klinik und Poliklinik fYr Urologie, CUB Campus Benjamin Franklin, Freie Universitat Berlin, 12200 Berlin, Germany
    Int J Mol Med 13:685-90. 2004
    Therapeutic procedures in patients with testicular germ cell tumors (GCT) are determined by the histopathology of the primary tumor and the tumor extension...
  96. doi Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center
    David Ruiz-Carrillo
    Probiodrug AG, Weinbergweg 22, D 06120 Halle, Saale, Germany
    Biochemistry 50:6280-8. 2011
    ..This study presents a first comparison of two mammalian QCs containing typical, conserved post-translational modifications...
  97. ncbi Screening for gestational diabetes mellitus in Nigerian pregnant women using fifty-gram oral glucose challenge test
    O Adegbola
    Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos Lagos University Teaching Hospital, Nigeria
    West Afr J Med 27:139-43. 2008
    ..Gestational Diabetes Mellitus (GDM) is frequently associated with adverse pregnancy outcome if not adequately managed. Prompt identification of these women requires a programme of active screening...
  98. ncbi Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89
    U Gobel
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Clin Oncol 19:1943-50. 2001
    To evaluate a multimodal approach including surgery and cisplatinum chemotherapy for treatment of children with malignant sacrococcygeal germ cell tumors (GCT) and to compare adjuvant and neoadjuvant strategies in advanced tumors.
  99. ncbi Granulosa cell tumors of the ovary: do they have any unique ultrasonographic and color Doppler flow features?
    R Sharony
    Ultrasound and Gynecological Oncology Units, Department of Obstetrics and Gynecology, Meir Hospital, Sapir Medical Center, Kfar Saba, affiliated with the Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Int J Gynecol Cancer 11:229-33. 2001
    The aim of this study was to describe the ultrasonographic and Doppler flow attributes of granulosa cell tumors (GCT) of the ovary and to compare these attributes to those of epithelial tumors of the ovary...
  100. ncbi MICA A8: a new allele within MHC class I chain-related A transmembrane region with eight GCT repeats
    Giovanni Gambelunghe
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Perugia, Italy
    Hum Immunol 67:1005-7. 2006
    Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region...
  101. ncbi Multimodality treatment of germ cell cancer patients who had progression or relapse after high dose chemotherapy and autologous bone marrow transplantation
    T Sarosiek
    Department of Oncology, Bone Marrow Transplantation Unit, Military Institute of Health Services, Warsaw, Poland
    J BUON 12:335-40. 2007
    When a patient with germ cell tumor (GCT) fails to be cured with high dose chemotherapy (HDC) and autologous haematopoietic stem cell transplantation (auto- BMT) the overall prognosis is very poor and any further treatment has only ..

Research Grants78

  1. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2011
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  2. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment ..
  3. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2004
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  4. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2005
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  5. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2005
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  6. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2006
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  7. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2013
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  8. Pyroglutamate Amyloid-beta as an Immunotherapeutic Target for Alzheimer's Disease
    Cynthia A Lemere; Fiscal Year: 2013
    ..A[unreadable] is generated upon N-terminal truncation of A[unreadable] followed by cyclization by glutaminyl cyclase to convert glutamic acid at residues 3 and 11 to pyroglutamate (A[unreadable]pE3 and A[unreadable]pE11)...
  9. Pyroglutamate Amyloid-beta as an Immunotherapeutic Target for Alzheimer's Disease
    Cynthia A Lemere; Fiscal Year: 2013
    ..A[unreadable] is generated upon N-terminal truncation of A[unreadable] followed by cyclization by glutaminyl cyclase to convert glutamic acid at residues 3 and 11 to pyroglutamate (A[unreadable]pE3 and A[unreadable]pE11)...
  10. Cyclin D as a Retinoid Differentiation Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2010
    ..will provide critical insights into the Hh pathway in regulating apoptosis, self-renewal or differentiation of GCT or other tumors...
  11. A pilot study of DNA methylation in pediatric germ cell tumors
    Jenny N Poynter; Fiscal Year: 2010
    ..by environmental exposures, with the goal of establishing a large genetic epidemiology study of pediatric GCT in the Children's Oncology Group...
  12. Molecular Epidemiology of Pediatric Germ Cell Tumors
    Jenny N Poynter; Fiscal Year: 2013
    ..Cases of pediatric GCT (ages 0-19 years) diagnosed from July 1, 2008-December 31, 2015 will be identified through the CCRN and will be ..
  13. Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    Vivian Y H Hook; Fiscal Year: 2013
    ..aminopeptidase enzymes generate A [unreadable] (3-40/42) which is converted to pGluA[unreadable](3-40/42) by glutaminyl cyclase (QC)...
  14. TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.
    Mary Vore; Fiscal Year: 2010
    ..The Training Program is based in the Graduate Center for Toxicology (GCT), a basic science department in the College of Medicine that grants the Ph.D...
  15. TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.
    Mary Vore; Fiscal Year: 2013
    ..The Training Program is based in the Graduate Center for Toxicology (GCT), a basic science department in the College of Medicine that grants the Ph.D...
  16. Mouse model for juvenile granulosa cell tumorigenesis
    ORA PESCOVITZ; Fiscal Year: 2003
    ..In order to test the hypothesis that the FSH-R pathway is involved in GCT pathogenesis, we will utilize a unique mouse model for GCT formation...
  17. Mouse model for juvenile granulosa cell tumorogenesis
    ROSEMARY STEINEMETZ; Fiscal Year: 2004
    ..In order to test the hypothesis that the FSH-R pathway is involved in GCT pathogenesis, we will utilize a unique mouse model for GCT formation...
  18. Agilent 6550 QTOF system for U of Utah
    JAMES ERIC COX; Fiscal Year: 2013
    ..This system will complement our current Waters GCT-Premier GC-MS and will be used immediately at full capacity...
  19. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2007
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  20. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2003
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  21. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2004
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  22. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2005
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  23. Steroid-Catecholamine Interactions and Behavior
    GREGORY BALL; Fiscal Year: 2006
    ..behavior and focuses on the specific projection of preoptic aromatase cells to the mesencephalic central gray (GCt)...
  24. Cyclin D as a Retinoid Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2006
    This revised new NIH R01 application evaluates cyclin D1 as a molecular target for germ cell tumor (GCT) growth, maturation, and chemotherapy response...
  25. Cyclin D as a Retinoid Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2007
    This revised new NIH R01 application evaluates cyclin D1 as a molecular target for germ cell tumor (GCT) growth, maturation, and chemotherapy response...
  26. Cyclin D as a Retinoid Molecular Target
    Ethan Dmitrovsky; Fiscal Year: 2005
    This revised new NIH R01 application evaluates cyclin D1 as a molecular target for germ cell tumor (GCT) growth, maturation, and chemotherapy response...
  27. EXPANSION OF PROGENITORS IN BREAST CANCER
    Camille Abboud; Fiscal Year: 1993
    ..expressing the membrane bound form of human SCF, and b) with the IL-11, IL-1alpha/beta, CSF producing mesenchymal GCT cell line...
  28. A pilot study of DNA methylation in pediatric germ cell tumors
    JENNY POYNTER; Fiscal Year: 2009
    ..by environmental exposures, with the goal of establishing a large genetic epidemiology study of pediatric GCT in the Children's Oncology Group...
  29. REOVIRUSES AS PROBES OF GUT-MUCOSAL T-CELL IMMUNITY
    STEVEN LONDON; Fiscal Year: 1993
    ..and a transient rise in the proportion of CD8+ T cells in PP which express a novel cell surface antigen termed GCT. While the functional significance of tide GCT+ B cell population is as yet undefined, we have demonstrated that ..
  30. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2002
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  31. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2000
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  32. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2001
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  33. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2002
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  34. CYTIDYLYTRANSFERASE STRUCTURE & FUNCTION
    Claudia Kent; Fiscal Year: 2003
    ..which included CTP:phosphoethanolamine cytidylytransferase (ECT) and CTP:glycerol-3-phosphate cytidylyltransferase (GCT). ECT participates in the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis in eukaryotes...
  35. MODIFICATION OF EFFERENT IMMUNOLOGICAL RESPONSES
    Joseph Glorioso; Fiscal Year: 2002
    ..with two consecutive components involving a) pre- and post-surgical intracranial NUREL-C2 inoculation followed by GCT treatment, and b) stereotactic NUREL-C2 delivery into the tumor with maintenance on GCV and gamma knife ..
  36. EGF GENE REGULATION IN KIDNEY AND SUBMANDIBULAR GLAND
    RUTH GUBITS; Fiscal Year: 1990
    ..The major source of mouse EGF is the granular convoluted tubule (GCT) cells of the submandibular salivary gland, which also produce nerve growth factor, renin and kallikreins...
  37. SALIVARY EPITHELIAL CELLS: BEHAVIOR AND ONCOGENE EFFECTS
    ELISA DURBAN; Fiscal Year: 1990
    ..that the effects of v-src are restricted to the EGF- synthesizing cells of the granular convoluted tubules (GCT)...
  38. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 1999
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  39. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2001
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  40. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2002
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  41. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2000
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  42. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..Germ cell tumor (GCT) of the testis is considered a model for the curable cancer, with 70 percent of patients with advanced GCT cured by ..
  43. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 1999
    ..g., bax, bcl-2, p21) will be assessed. His preliminary data in two GCT cell lines (one drug-sensitive (TP53 wild-type) and one drug-resistant (TP53 mutant)) show failure to upregulate ..
  44. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 2000
    ..g., bax, bcl-2, p21) will be assessed. His preliminary data in two GCT cell lines (one drug-sensitive (TP53 wild-type) and one drug-resistant (TP53 mutant)) show failure to upregulate ..
  45. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..Hypotheses: Two-step screening by a one hour oral glucose challenge test (GCT) followed, if abnormal, by an OGTT will have good predictive ability to identify IGT, and will be superior to "..
  46. PROGENITOR CELL-MICROENVIRONMENT INTERACTIONS
    Jane Liesveld; Fiscal Year: 1990
    ..In phase iI, the giant cell tumor (GCT) cell line, a mesenchymal cell line which stimulating factor (GM-CSF), granulocyte CSF, and macrophage CSF will be ..
  47. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2006
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  48. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2003
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  49. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2004
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  50. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2005
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  51. Oct-4 Regulates Embryonal Carcinoma Differentiation
    Robert Hromas; Fiscal Year: 2007
    An intriguing characteristic of metastatic embryonal carcinoma, a type of germ cell tumor (GCT), is that they are able to differentiate to localized teratoma, which is made up of more mature, slower growing tissue of all three embryonic ..
  52. CLINICAL CORRELATIVE STUDIES IN GERM CELL TUMORS
    George Bosl; Fiscal Year: 1993
    Germ Cell Tumors (GCT) are a curable malignancy in which the physician must discriminate between good risk and poor risk attributes and choose a treatment program designed for good risk or poor risk patients...
  53. ISOLATION OF AMPLIFIED GENE IN HUMAN GERM CELL TUMORS
    Jane Houldsworth; Fiscal Year: 1991
    ..Preparative in-gel renaturation assays will be. performed on DNA extracted from a GCT cell line with a homogeneously staining region (HSR)...
  54. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  55. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2000
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  56. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) The etiology of germ cell tumors (GCT) is poorly understood...
  57. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2009
    ..The Training Program is based in the Graduate Center for Toxicology (GCT) which grants the Ph.D. in Toxicology, and provides an administrative and teaching nucleus of 6 core faculty...
  58. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2007
    ..The Training Program is based in the Graduate Center for Toxicology (GCT) which grants the Ph.D. in Toxicology, and provides an administrative and teaching nucleus of 6 core faculty...
  59. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2006
    ..The Training Program is based in the Graduate Center for Toxicology (GCT) which grants the Ph.D. in Toxicology, and provides an administrative and teaching nucleus of 6 core faculty...
  60. MOLECULAR MECHANISMS OF TOXICITY TRAINING GRANT
    Mary Vore; Fiscal Year: 2005
    ..The Training Program is based in the Graduate Center for Toxicology (GCT) which grants the Ph.D. in Toxicology, and provides an administrative and teaching nucleus of 6 core faculty...
  61. MECHANISMS OF SALIVARY GLAND DEVELOPMENT
    Paul Denny; Fiscal Year: 1990
    ..and protein synthesis studies on epidermal growth factor (EGF) will determine if granular convoluted tubule cells (GCT) likewise pass thought a protodifferentiated stage...
  62. ANTIOXIDANT ENZYMES AND CARDIAC INJURY
    Daret St Clair; Fiscal Year: 1999
    ..courses but will also participate in a number of team-taught courses offered by the Graduate Center for Toxicology (GCT)...
  63. ANTIOXIDANT ENZYMES AND CARDIAC INJURY
    Daret St Clair; Fiscal Year: 2000
    ..courses but will also participate in a number of team-taught courses offered by the Graduate Center for Toxicology (GCT)...
  64. SOUTHWEST ONCOLOGY GROUP
    Heinz Josef Lenz; Fiscal Year: 2007
    ..b>GCT bladder CA trial; NCI UO-1 funded pharmacology and molecular prediction of outcome studies in phase II geriatric ..