GLUT1

Summary

Gene Symbol: GLUT1
Description: solute carrier family 2 member 1
Alias: CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED, SDCHCN, solute carrier family 2, facilitated glucose transporter member 1, choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity), glucose transporter type 1, erythrocyte/brain, hepG2 glucose transporter, human T-cell leukemia virus (I and II) receptor, receptor for HTLV-1 and HTLV-2, solute carrier family 2 (facilitated glucose transporter), member 1
Species: human
Products:     GLUT1

Top Publications

  1. Brockmann K, Wang D, Korenke C, von Moers A, Ho Y, Pascual J, et al. Autosomal dominant glut-1 deficiency syndrome and familial epilepsy. Ann Neurol. 2001;50:476-85 pubmed
    b>Glut-1 deficiency syndrome was first described in 1991 as a sporadic clinical condition, later shown to be the result of haploinsufficiency. We now report a family with Glut-1 deficiency syndrome affecting 5 members over 3 generations...
  2. Cooper R, Sarioglu S, Sokmen S, Fuzun M, Kupelioglu A, Valentine H, et al. Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?. Br J Cancer. 2003;89:870-6 pubmed
    The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia...
  3. Gu J, Yamamoto H, Fukunaga H, Danno K, Takemasa I, Ikeda M, et al. Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-D-glucose uptake by positron emission tomography in colorectal cancer. Dig Dis Sci. 2006;51:2198-205 pubmed
    ..0004, .042, respectively). Strong glucose transporter-1 (GLUT-1) expression had significantly positive correlation with the SUV (r=.619, P=.003)...
  4. Wincewicz A, Sulkowska M, Koda M, Sulkowski S. Clinicopathological significance and linkage of the distribution of HIF-1alpha and GLUT-1 in human primary colorectal cancer. Pathol Oncol Res. 2007;13:15-20 pubmed
    HIF-1alpha induces GLUT-1 expression, and their presence has been evaluated in colorectal cancer...
  5. Weber Y, Storch A, Wuttke T, Brockmann K, Kempfle J, Maljevic S, et al. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. J Clin Invest. 2008;118:2157-68 pubmed publisher
    ..deletion of 4 highly conserved amino acids (Q282_S285del) in the pore region of the glucose transporter 1 (GLUT1)...
  6. Kim J, Kim S, Do I, Jin J, Nam D, Ko Y, et al. Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?. Leuk Lymphoma. 2011;52:205-13 pubmed publisher
    ..1? (HIF-1?) and its downstream proteins, vascular endothelial growth factor (VEGF) and glucose transporter 1 (GLUT-1), were evaluated in a central nervous system (CNS) lymphoma xenograft model and in human PCNSL tissue...
  7. Mueckler M, Caruso C, Baldwin S, Panico M, Blench I, Morris H, et al. Sequence and structure of a human glucose transporter. Science. 1985;229:941-5 pubmed
    ..Messenger RNA species homologous to HepG2 glucose transporter messenger RNA were detected in K562 leukemic cells, HT29 colon adenocarcinoma cells, and human kidney ..
  8. Olson A, Pessin J. Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr. 1996;16:235-56 pubmed
    ..b>GLUT1, the first GLUT isoform identified, is expressed at highest levels in the endothelial of barrier tissues such as ..
  9. Hodgkinson A, Millward B, Demaine A. Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy. Kidney Int. 2001;59:985-9 pubmed
    ..Glucose transporter (GLUT1) activity has been implicated in renal hypertrophy and extracellular matrix formation in mesangial cells...

More Information

Publications69

  1. Zhang J, Hayashi H, Ebina Y, Prohaska R, Ismail Beigi F. Association of stomatin (band 7.2b) with Glut1 glucose transporter. Arch Biochem Biophys. 1999;372:173-8 pubmed
    Employing a monoclonal antibody directed against the C-terminal peptide of glucose transporter molecule 1 (Glut1), we identified a approximately 30-kDa polypeptide which coimmunoprecipitated with Glut1 from sample of human red blood ..
  2. Basturk O, Singh R, Kaygusuz E, Balci S, Dursun N, Culhaci N, et al. GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis. Pancreas. 2011;40:187-92 pubmed publisher
    b>GLUT-1 has been found to have an important role in the upregulation of various cellular pathways and implicated in neoplastic transformation correlating with biological behavior in malignancies...
  3. Hruz P, Mueckler M. Structural analysis of the GLUT1 facilitative glucose transporter (review). Mol Membr Biol. 2001;18:183-93 pubmed
    The structure of the human erythrocyte facilitative glucose transporter (GLUT1) has been intensively investigated using a wide array of chemical and biophysical approaches...
  4. Grabellus F, Sheu S, Bachmann H, Lehmann N, Otterbach F, Heusner T, et al. The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer. J Nucl Med. 2010;51:1191-7 pubmed publisher
    We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of (18)F-FDG and tumor aggressiveness in breast cancer...
  5. Mobasheri A, Neama G, Bell S, Richardson S, Carter S. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int. 2002;26:297-300 pubmed
    ..Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes...
  6. Makni K, Jarraya F, Rebai M, Mnif F, Boudawara M, Hamza N, et al. Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population. Ann Hum Biol. 2008;35:490-8 pubmed publisher
    ..Here we report the findings of a case-control study on five SNPs in the glucose transporter 1 (GLUT1) gene. The study investigated the association of five GLUT1 genotypes and haplotypes with DN...
  7. Ayala F, Rocha R, Carvalho K, Carvalho A, da Cunha I, Lourenço S, et al. GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. Molecules. 2010;15:2374-87 pubmed publisher
    ..C.Camargo hospital records. A tissue microarray (TMA) was built for the immunohistochemical (IHC) analysis of GLUT 1 and GLUT 3. IHC results were evaluated according to the staining pattern and number of positive cells...
  8. Coskun A, Sutton R. Expression of glucose transporter 1 confers susceptibility to human T-cell leukemia virus envelope-mediated fusion. J Virol. 2005;79:4150-8 pubmed
    ..Despite years of study, only recently has a bona fide candidate cellular receptor, glucose transporter 1 (glut-1), been identified...
  9. Hodgkinson A, Page T, Millward B, Demaine A. A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. J Diabetes Complications. 2005;19:65-9 pubmed
    Glucose transporter 1 (GLUT1) activity has been implicated in renal hypertrophy and extracellular matrix formation in mesangial cells...
  10. Kalir T, Wang B, Goldfischer M, Haber R, Reder I, Demopoulos R, et al. Immunohistochemical staining of GLUT1 in benign, borderline, and malignant ovarian epithelia. Cancer. 2002;94:1078-82 pubmed
    Aberrant expression of the facilitative glucose transporter GLUT1 is found in a wide spectrum of epithelial malignancies...
  11. Xiong Y, Xiong Y, Zhou Y. Expression and significance of beta-catenin, Glut-1 and PTEN in proliferative endometrium, endometrial intraepithelial neoplasia and endometrioid adenocarcinoma. Eur J Gynaecol Oncol. 2010;31:160-4 pubmed
    The aim of this study was to explore the potentiality of beta-catenin, Glut-1 and PTEN proteins as markers for a diagnosis of endometrial intraepithelial neoplasia (EIN).
  12. Tarnow L, Grarup N, Hansen T, Parving H, Pedersen O. Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients. Nephrol Dial Transplant. 2001;16:1653-6 pubmed
    An XbaI polymorphism in the gene encoding the glucose transporter, GLUT-1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients...
  13. Flatt J, Guizouarn H, Burton N, Borgese F, Tomlinson R, Forsyth R, et al. Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome. Blood. 2011;118:5267-77 pubmed publisher
    ..The molecular basis of the glut1DS, paroxysmal exercise-induced dyskinesia, and sdCHC phenotypes are compared and discussed.
  14. Chandler J, Williams E, Slavin J, Best J, Rogers S. Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Cancer. 2003;97:2035-42 pubmed
    ..Increased expression of GLUT1 is a characteristic of many malignant cells...
  15. Robichaud T, Appleyard A, Herbert R, Henderson P, Carruthers A. Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial site. Biochemistry. 2011;50:3137-48 pubmed publisher
    Cytochalasin B (CB) and forskolin (FSK) inhibit GLUT1-mediated sugar transport in red cells by binding at or close to the GLUT1 endofacial sugar binding site...
  16. Mueckler M, Makepeace C. Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis. Biochemistry. 2009;48:5934-42 pubmed publisher
    Transmembrane helix 9 of the Glut1 glucose transporter was analyzed by cysteine-scanning mutagenesis and the substituted cysteine accessibility method (SCAM)...
  17. Wei B, Chen L, Li J. [Expression of glucose transporter 1 in gastric carcinoma and metastatic lymph nodes and its association with prognosis]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:277-80 pubmed
    To examine the expression and distribution of glucose transporter 1(GLUT1) in gastric cancer tissues and investigate its relation to clinicopathological parameters and prognosis of patients with gastric carcinoma...
  18. Klepper J, Willemsen M, Verrips A, Guertsen E, Herrmann R, Kutzick C, et al. Autosomal dominant transmission of GLUT1 deficiency. Hum Mol Genet. 2001;10:63-8 pubmed
    b>GLUT1 deficiency is caused by a defect in the facilitative glucose transporter GLUT1...
  19. Auburger G, Ratzlaff T, Lunkes A, Nelles H, Leube B, Binkofski F, et al. A gene for autosomal dominant paroxysmal choreoathetosis/spasticity (CSE) maps to the vicinity of a potassium channel gene cluster on chromosome 1p, probably within 2 cM between D1S443 and D1S197. Genomics. 1996;31:90-4 pubmed
    ..This gene locus on chromosome 12p (HGMW-approved symbol CSE) was excluded in a large pedigree with paroxysmal choreoathetosis and additional spasticity...
  20. Zamudio S, Baumann M, Illsley N. Effects of chronic hypoxia in vivo on the expression of human placental glucose transporters. Placenta. 2006;27:49-55 pubmed
    ..We therefore investigated the expression of a primary nutrient transporter, the GLUT1 glucose transporter and two in vitro markers of hypoxia (erythropoietin receptor, EPO-R, and transferrin receptor, ..
  21. Sasaki H, Shitara M, Yokota K, Hikosaka Y, Moriyama S, Yano M, et al. Overexpression of GLUT1 correlates with Kras mutations in lung carcinomas. Mol Med Rep. 2012;5:599-602 pubmed publisher
    Glucose is the major source of energy for cells, and glucose transporter 1 (GLUT1) is the most common glucose transporter. GLUT1 has been found to be aberrantly expressed in several tumor types...
  22. Wincewicz A, Sulkowska M, Koda M, Kanczuga Koda L, Witkowska E, Sulkowski S. Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer. Ann N Y Acad Sci. 2007;1095:53-61 pubmed
    Hypoxic cancer cells overexpress Glucose transporter 1 (GLUT-1) to accelerate glucose intake mainly for low effective, anaerobic respiration, so that they would not die of oxygen deficiency. Ischemic cell injury triggers apoptosis...
  23. Ozbudak I, Shilo K, Tavora F, Rassaei N, Chu W, Fukuoka J, et al. Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. Mod Pathol. 2009;22:633-8 pubmed publisher
    Glucose transporter-1 (GLUT-1) mediates the transport of glucose across the cellular membrane. Its elevated levels and/or activation have been shown to be associated with malignancy...
  24. Levine K, Robichaud T, Hamill S, Sultzman L, Carruthers A. Properties of the human erythrocyte glucose transport protein are determined by cellular context. Biochemistry. 2005;44:5606-16 pubmed
    Human erythrocyte hexose transfer is mediated by the glucose transport protein GLUT1 and is characterized by a complexity that is unexplained by available hypotheses for carrier-mediated sugar transport [Cloherty, E. K., Heard, K. S...
  25. Mueckler M, Makepeace C. Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity. J Biol Chem. 2008;283:11550-5 pubmed publisher
    Experimental data and homology modeling suggest a structure for the exofacial configuration of the Glut1 glucose transporter in which 8 transmembrane helices form an aqueous cavity in the bilayer that is stabilized by four outer helices...
  26. Richardson S, Neama G, Phillips T, Bell S, Carter S, Moley K, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003;11:92-101 pubmed
    ..Expression of GLUT1, GLUT3 and GLUT9 proteins in normal human articular cartilage was confirmed by immunohistochemistry...
  27. Manel N, Battini J, Sitbon M. Human T cell leukemia virus envelope binding and virus entry are mediated by distinct domains of the glucose transporter GLUT1. J Biol Chem. 2005;280:29025-9 pubmed publisher
    The glucose transporter GLUT1, a member of the multimembrane-spanning facilitative nutrient transporter family, serves as a receptor for human T cell leukemia virus (HTLV) infection...
  28. Kato Y, Tsuta K, Seki K, Maeshima A, Watanabe S, Suzuki K, et al. Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol. 2007;20:215-20 pubmed
    ..A family of glucose transporter isoforms (GLUT), of which GLUT-1 is a member, facilitate the entry of glucose into cells...
  29. Manel N, Kim F, Kinet S, Taylor N, Sitbon M, Battini J. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell. 2003;115:449-59 pubmed
    ..receptor binding domains of both HTLV-1 and -2 envelope glycoproteins inhibit glucose transport by interacting with GLUT-1, the ubiquitous vertebrate glucose transporter...
  30. Zintzaras E, Stefanidis I. Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis. J Hum Genet. 2005;50:84-91 pubmed
    The association between diabetic nephropathy (DN) and the XbalphaI polymorphism in the GLUT1 gene has been investigated in several case-control studies...
  31. Sulkowska M, Wincewicz A, Sulkowski S, Koda M, Kanczuga Koda L. Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients. Pathology. 2009;41:254-60 pubmed publisher
    ..and cancer cell survival factors hypoxia inducible factor-1 alpha (HIF-1 alpha) and glucose transporter 1 (GLUT-1) by immunohistochemistry in 108 colorectal cancers...
  32. Jin Q, Agrawal L, VanHorn Ali Z, Alkhatib G. Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter GLUT-1: evidence using antibodies specific to the receptor's large extracellular domain. Virology. 2006;349:184-96 pubmed
    ..We used this system in a functional cDNA screening to isolate and confirm that the glucose transporter protein 1 (GLUT-1) is a receptor for HTLV-1...
  33. Mueckler M, Makepeace C. Transmembrane segment 12 of the Glut1 glucose transporter is an outer helix and is not directly involved in the transport mechanism. J Biol Chem. 2006;281:36993-8 pubmed
    A model has been proposed for the exofacial configuration of the Glut1 glucose transporter in which eight transmembrane domains form an inner helical bundle stabilized by four outer helices...
  34. Manel N, Kinet S, Battini J, Kim F, Taylor N, Sitbon M. The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis. Blood. 2003;101:1913-8 pubmed
    ..Up-regulation of the HTLV receptor, via signals transmitted through the IL-7 cytokine receptor as well as the TCR, is likely to contribute to the mother-to-infant transmission and spreading of HTLV-1. ..
  35. Leary L, Wang D, Nordli D, Engelstad K, De Vivo D. Seizure characterization and electroencephalographic features in Glut-1 deficiency syndrome. Epilepsia. 2003;44:701-7 pubmed
    ..To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). Twenty children with clinical and laboratory features of Glut-1 DS were evaluated...
  36. Cleven A, van Engeland M, Wouters B, De Bruine A. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol. 2007;29:229-40 pubmed
    ..of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase 9 (CA9) and glucose transporter 1 (GLUT1) in patients with colorectal adenocarcinomas...
  37. Ng D, Canani L, Araki S, Smiles A, Moczulski D, Warram J, et al. Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes. Diabetes. 2002;51:2264-9 pubmed
    Elevation of intracellular glucose in mesangial cells as mediated by GLUT1 may be important in initiating cellular mechanisms that cause diabetic nephropathy...
  38. Pinheiro C, Sousa B, Albergaria A, Paredes J, Dufloth R, Vieira D, et al. GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. Histol Histopathol. 2011;26:1279-86 pubmed publisher
    The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer...
  39. Peansukmanee S, Vaughan Thomas A, Carter S, Clegg P, Taylor S, Redmond C, et al. Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J Orthop Res. 2009;27:529-35 pubmed publisher
    ..chloride (CoCl(2)) on glucose transport in equine chondrocytes and compared expression of the hypoxia responsive GLUT1 gene in normal and diseased cartilage...
  40. Blodgett D, Carruthers A. Quench-flow analysis reveals multiple phases of GluT1-mediated sugar transport. Biochemistry. 2005;44:2650-60 pubmed
    ..These data support a transport mechanism in which newly bound sugars are transiently sequestered within the translocation pathway where they become inaccessible to extra- and intracellular water. ..
  41. Alisio A, Mueckler M. Purification and characterization of mammalian glucose transporters expressed in Pichia pastoris. Protein Expr Purif. 2010;70:81-7 pubmed publisher
    ..A simple and rapid method is described for the purification of milligram quantities of recombinant GLUT1 and GLUT4, two of the most intensively studied GLUT isoforms, after ectopic expression in Pichia pastoris...
  42. Brockmann K. The expanding phenotype of GLUT1-deficiency syndrome. Brain Dev. 2009;31:545-52 pubmed publisher
    ..across the blood-brain barrier to the central nervous system is facilitated by glucose transport protein type 1 (GLUT1), the first member of the solute carrier family 2 (SLC2)...
  43. Hebert D, Carruthers A. Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1. J Biol Chem. 1992;267:23829-38 pubmed
    This study investigates the relationship between human erythrocyte glucose transport protein (GLUT1) oligomeric structure and glucose transporter function...
  44. Usuda K, Sagawa M, Aikawa H, Ueno M, Tanaka M, Machida Y, et al. Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer. Gen Thorac Cardiovasc Surg. 2010;58:405-10 pubmed publisher
    The aim of this study was to determine if glucose transporter-1 (Glut1) expression correlates with (18)F-FDG ((18)F-fluoro-2-deoxyglucose) uptake on positron emission tomography (PET) in lung cancer and to examine the similarities and ..
  45. Park S, Lee J, Lee W, Han K. Biologic correlation between glucose transporters, hexokinase-II, Ki-67 and FDG uptake in malignant melanoma. Nucl Med Biol. 2012;39:1167-72 pubmed publisher
    ..between tumoral 2-deoxy-2-[(18)F]-fluoro-D-glucose (FDG) uptake, and the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3 (GLUT-3), hexokinase II (HK-2), and Ki-67 expression in malignant melanoma...
  46. Fenske W, Völker H, Adam P, Hahner S, Johanssen S, Wortmann S, et al. Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma. Endocr Relat Cancer. 2009;16:919-28 pubmed publisher
    ..cells and in a variety of tumour entities key factors in glucose metabolism like glucose transporter 1 and 3 (GLUT1 and -3), transketolase like-1 enzyme (TKTL1) and pyruvate kinase type M2 (M2-PK) are overexpressed and of ..
  47. Shao S, Cai Y, Wang Q, Yan L, Zhao X, Wang L. [Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]. Zhonghua Zhong Liu Za Zhi. 2007;29:697-700 pubmed
    To investigate the expression of GLUT1, p63 and DNA-Pkcs in serous ovarian tumors and their significance. GTUL1, p63 and DNA-Pkcs expression at protein level was detected by immunohistochemistry in patients with serous ovarian tumors...
  48. Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, et al. Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis. Oncol Rep. 2007;18:361-7 pubmed
    ..The rates of expression of GLUT1, GLUT3 and GLUT4 were 98.7%, 92.8% and 84.4%, respectively...
  49. Rudlowski C, Moser M, Becker A, Rath W, Buttner R, Schroder W, et al. GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology. 2004;66:404-10 pubmed
    ..The aim of the present study was to analyze the expression of different GLUT isoforms (GLUT1-4) and to investigate whether alterations in their expression pattern accompany the malignant transformation and ..
  50. Mueckler M, Makepeace C. Analysis of transmembrane segment 8 of the GLUT1 glucose transporter by cysteine-scanning mutagenesis and substituted cysteine accessibility. J Biol Chem. 2004;279:10494-9 pubmed
    The GLUT1 glucose transporter has been proposed to form an aqueous substrate translocation pathway via the clustering of several amphipathic transmembrane helices (Mueckler, M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I...
  51. Grzeszczak W, Moczulski D, Zychma M, Zukowska Szczechowska E, Trautsolt W, Szydlowska I. Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes. Kidney Int. 2001;59:631-6 pubmed
    The XbaI polymorphism in the glucose transporter GLUT1 gene has been implicated in the development of diabetic nephropathy in Chinese type 2 diabetes patients...
  52. Hao L, Ni Q, Jia G, Wang G, Qian K, Liu Y, et al. [Expression of glucose transporter 1 in human breast carcinoma and its clinical significance]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:44-7 pubmed
    To investigate the expression of glucose transporter 1 (Glut1) in human breast cancer and its relationship to proliferating cell nuclear antigen (PCNA) protein, other tumor biomarkers and clinical pathologic factors...
  53. Mayer A, Hockel M, Vaupel P. Endogenous hypoxia markers: case not proven!. Adv Exp Med Biol. 2008;614:127-36 pubmed publisher
    ..g., glucose transporter (GLUT)-1 and carbonic anhydrase (CA) IX, have been considered to be suitable as surrogate biomarkers of hypoxia due to ..
  54. Ito S, Fukusato T, Nemoto T, Sekihara H, Seyama Y, Kubota S. Coexpression of glucose transporter 1 and matrix metalloproteinase-2 in human cancers. J Natl Cancer Inst. 2002;94:1080-91 pubmed
    Cancer cells express higher levels of glucose transporter proteins (Gluts) than do normal cells. Glut-1 overexpression is associated with invasiveness...
  55. Loisel Meyer S, Swainson L, Craveiro M, Oburoglu L, Mongellaz C, Costa C, et al. Glut1-mediated glucose transport regulates HIV infection. Proc Natl Acad Sci U S A. 2012;109:2549-54 pubmed publisher
    ..We identify the IL-7-induced increase in Glut1 expression, resulting in augmented glucose uptake, as a key factor in rendering these T lymphocytes susceptible to ..
  56. Fukumoto H, Seino S, Imura H, Seino Y, Bell G. Characterization and expression of human HepG2/erythrocyte glucose-transporter gene. Diabetes. 1988;37:657-61 pubmed
    ..The promoter region includes a TATA motif and two binding sites for the transcription factor Spl as well as a sequence that is found in the promoter region of several phorbol ester-inducible genes. ..
  57. Schmidt M, Voelker H, Kapp M, Krockenberger M, Dietl J, Kammerer U. Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. J Cancer Res Clin Oncol. 2010;136:219-25 pubmed publisher
    ..glucose utilisation has been described for different tumours characterised by activation of Akt, upregulation of GLUT1, M2PK and TKTL1. To date, however, little is known about glucose metabolism in breast cancer tissue...
  58. Levine K, Cloherty E, Hamill S, Carruthers A. Molecular determinants of sugar transport regulation by ATP. Biochemistry. 2002;41:12629-38 pubmed
    ..ATP inhibits human erythrocyte net sugar transport by binding cooperatively to the glucose transport protein (GluT1)...
  59. Yasuda M, Ogane N, Hayashi H, Kameda Y, Miyagi Y, Iida T, et al. Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma. Oncol Rep. 2005;14:1499-504 pubmed
    Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular ..