GluR1

Summary

Gene Symbol: GluR1
Description: glutamate ionotropic receptor AMPA type subunit 1
Alias: GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate receptor 1, AMPA 1, AMPA-selective glutamate receptor 1, gluR-1, gluR-A, gluR-K1, glutamate receptor, ionotropic, AMPA 1
Species: human
Products:     GluR1

Top Publications

  1. Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada N, Hagimura N, Okado H, et al. Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med. 2002;8:971-8 pubmed
    ..alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptors assembled from the GluR1 and/or GluR4 subunits, and that their conversion to Ca(2+)-impermeable receptors by adenovirus-mediated transfer ..
  2. Piao Y, Lu L, de Groot J. AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. Neuro Oncol. 2009;11:260-73 pubmed publisher
    ..Overexpression of GluR1, the most abundant AMPAR subunit in gliomas, positively correlated with glioma cell adhesion to type I and type IV ..
  3. de Groot J, Piao Y, Lu L, Fuller G, Yung W. Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation. J Neurooncol. 2008;88:121-33 pubmed publisher
    ..shRNA was used to stably knockdown GluR1, the most abundant AMPA receptor subunit in glioma, to evaluate its role in tumor signaling, proliferation and ..
  4. van Vuurden D, Yazdani M, Bosma I, Broekhuizen A, Postma T, Heimans J, et al. Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PLoS ONE. 2009;4:e5953 pubmed publisher
    ..In vitro, in all GBM samples tested, mRNA expression of AMPAR subunit GluR1, 2 and 4 was relatively low compared to adult and fetal total brain mRNA and adult cerebellum mRNA...
  5. Sanchez Catalan M, Kaufling J, Georges F, Veinante P, Barrot M. The antero-posterior heterogeneity of the ventral tegmental area. Neuroscience. 2014;282:198-216 pubmed publisher
    ..It has also been observed after viral-mediated manipulation of GluR1, phospholipase Cγ (PLCγ) and cAMP response element binding protein (CREB) expression, with impact on reward ..
  6. Carr H, Alexander T, Groves T, Kiffer F, Wang J, PRICE E, et al. Early effects of 16O radiation on neuronal morphology and cognition in a murine model. Life Sci Space Res (Amst). 2018;17:63-73 pubmed publisher
    ..Exposure to 16O significantly reduced the expression of Nr1 and GluR1 in the hippocampus and modulated spine morphology in the dentate gyrus and cornu Ammon 1 within the hippocampus...
  7. Wang H, Huang F, Hu Z, Zhang W, Qiao X, Huang Y, et al. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotox Res. 2017;31:505-520 pubmed publisher
    ..ESI also decreased expression of hippocampal NMDA receptor subunits, NR1, and AMPA receptor subunits, GluR1 and GluR2, which are involved in synaptic plasticity, but it did not affect expression of PSD95 and NR2B...
  8. Jung G, Kim E, Cicvaric A, Sase S, Gröger M, Höger H, et al. Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. J Neurochem. 2015;134:327-39 pubmed publisher
    ..significantly reduced in hippocampus of drebrin knockout mice whereas no significant changes were detected for GluR1, 2, and 3 and NR1 as examined by native gel-based immunoblotting...
  9. Zhang S, Zhang Y, Li H, Xu W, Chu K, Chen L, et al. Antioxidant and anti-excitotoxicity effect of Gualou Guizhi decoction on cerebral ischemia/reperfusion injury in rats. Exp Ther Med. 2015;9:2121-2126 pubmed
    ..In addition, the levels of excitatory amino acids (EAAs) and glutamate receptor 1 (GluR1) were examined using an automatic amino acid analyzer and immunohistochemical analysis...

More Information

Publications127 found, 100 shown here

  1. Li H, Yu F, Sun X, Xu L, Miu J, Xiao P. Dihydromyricetin ameliorates memory impairment induced by acute sleep deprivation. Eur J Pharmacol. 2019;853:220-228 pubmed publisher
    ..The levels of proteins including those of GABABRS, GABAARα5, GluR1, BDNF and PSD95, were detected by western blotting...
  2. Tachibana M, Shinohara M, Yamazaki Y, Liu C, Rogers J, Bu G, et al. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Exp Neurol. 2016;277:1-9 pubmed publisher
    ..While levels of PSD95, glutamate receptor 1 (GluR1), and N-methyl-d-aspartate receptor NR1 subunit (NR1), which are key postsynaptic proteins that ..
  3. Fernandes A, Li Y. Focused microwave irradiation-assisted immunohistochemistry to study effects of ketamine on phospho-ERK expression in the mouse brain. Brain Res. 2017;1670:86-95 pubmed publisher
    ..phospho) proteins including phospho-ERK, phospho- cAMP-response- element-binding protein (CREB), phospho- glutamate receptor 1 (GluR1) and phospho- calcium/calmodulin-dependent protein kinase II (CaMKII) with greater sensitivity and ..
  4. Yao G, Yue H, Yun Y, Sang N. Chronic SO2 inhalation above environmental standard impairs neuronal behavior and represses glutamate receptor gene expression and memory-related kinase activation via neuroinflammation in rats. Environ Res. 2015;137:85-93 pubmed publisher
    ..abnormality, we detected that SO2 inhalation reduced the expression of Arc and glutamate receptor subunits (GluR1, GluR2, NR1, NR2A, and NR2B) with a concentration-dependent property in comparison to controls...
  5. Furukawa Y, Tanemura K, Igarashi K, Ideta Otsuka M, Aisaki K, Kitajima S, et al. Learning and Memory Deficits in Male Adult Mice Treated with a Benzodiazepine Sleep-Inducing Drug during the Juvenile Period. Front Neurosci. 2016;10:339 pubmed publisher
    ..In addition, decreased protein expression of GluR1 and GluR4, which are excitatory neurotransmitter receptors, was detected in the hippocampi of mice treated with TZ ..
  6. Gomaa A, Makboul R, El Mokhtar M, Abdel Rahman E, Ahmed I, Nicola M. Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Cytokine. 2019;113:405-416 pubmed publisher
    ..Furthermore, it elevated the suppressed glutamate receptor expression (AMPA GluR1 subunit and NMDA receptor subunits NR1, NR2A, NR2B)...
  7. Gulino R, Forte S, Parenti R, Gulisano M. TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration. CNS Neurol Disord Drug Targets. 2015;14:55-60 pubmed
    ..proteins such as synapsin-I and the α-amino-3-hydroxy-5-methyl-4- isoxazolepropionate (AMPA) receptor subunits GluR1, GluR2 and GluR4 were measured by western blotting...
  8. Nakao A, Miyazaki N, Ohira K, Hagihara H, Takagi T, Usuda N, et al. Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability. Mol Brain. 2017;10:60 pubmed publisher
    ..Shn2 KO mice exhibited a significant reduction in GluR1 expression and a nominally significant decrease in SV2 expression, while PSD95 expression had a non-significant ..
  9. Bruns R, Mitchell S, Wafford K, Harper A, Shanks E, Carter G, et al. Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders. Neuropharmacology. 2018;128:351-365 pubmed publisher
    ..DETQ also increased phosphorylation of the AMPA receptor (GluR1) and the transcription factor CREB in the striatum, consistent with enhanced synaptic plasticity...
  10. Wang T, Guan R, Liu M, Shen X, Chen J, Zhao M, et al. Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period. Mol Neurobiol. 2016;53:3740-3752 pubmed publisher
    ..NR2A and phosphorylated GluR1 expression decreased...
  11. Chen Z, Li T, Zhang L, Wang H, Hu F. Bisphenol A exposure remodels cognition of male rats attributable to excitatory alterations in the hippocampus and visual cortex. Toxicology. 2018;410:132-141 pubmed publisher
    ..decline in spine density of pyramidal neurons and a decreased expression of glutamate receptor subtypes (NR2 and GluR1) in the hippocampus...
  12. Wu H, Yen H, Huang C, Lee Y, Wu S, Lee T, et al. Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex. J Biomed Sci. 2015;22:94 pubmed publisher
    ..subunits NR1, NR2A, NR2B; the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits GluR1, GluR2, and ERK phosphorylation...
  13. Pawar H, Balivada S, Kenney M. Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?. Neurosci Lett. 2018;687:223-233 pubmed publisher
  14. Sundararajan T, Manzardo A, Butler M. Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. Gene. 2018;641:25-34 pubmed publisher
    ..Our approach to interrogate SCZ genes and their interactions at various levels has increased our knowledge and insight into the disease process possibly opening new avenues for therapeutic intervention...
  15. Blanco E, Pavón F, Palomino A, Luque Rojas M, Serrano A, Rivera P, et al. Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..cocaine, this inhibition was reversed and a strong increase was detected in the mGluR5, NR2 subunits, and both GluR1 and GluR3...
  16. De Jesus Cortes H, Lu Y, Anderson R, Khan M, Nath V, McDaniel L, et al. Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice. Neuroscience. 2016;329:66-73 pubmed publisher
    ..in synapses of MSNs in the ventral striatum, including fewer pre-synaptic glutamatergic vesicles and enhanced GluR1 function...
  17. Liu M, Fitzgibbon M, Wang Y, Reilly J, Qian X, O BRIEN T, et al. Ulk4 regulates GABAergic signaling and anxiety-related behavior. Transl Psychiatry. 2018;8:43 pubmed publisher
    ..This is the first evidence that Ulk4 plays a major role in regulating GABAergic signaling and anxiety-like behavior, which may have implications for the development of novel anxiolytic treatments. ..
  18. Pedraza N, Ortiz R, Cornadó A, Llobet A, Aldea M, Gallego C. KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling. J Neurosci. 2014;34:13988-97 pubmed publisher
    ..in a significant decrease of protein levels of PSD-95, a postsynaptic scaffolding protein, and the AMPAR subunits GluR1 and GluR2 in a CPEB3-dependent manner...
  19. Matos M, Shen H, Augusto E, Wang Y, Wei C, Wang Y, et al. Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol Psychiatry. 2015;78:763-74 pubmed publisher
    ..Accordingly, selective GLT-I inhibition or blockade of GluR1/2 endocytosis prevented the psychomotor and cognitive phenotypes in Gfa2-A2AR KO mice, namely in the nucleus ..
  20. Didriksen M, Fejgin K, Nilsson S, Birknow M, Grayton H, Larsen P, et al. Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice. J Psychiatry Neurosci. 2017;42:48-58 pubmed
    ..elevations of the dopamine metabolite DOPAC and increased dorsal striatal expression of the AMPA receptor subunit GluR1 was found...
  21. Cacciottolo M, Wang X, Driscoll I, Woodward N, Saffari A, Reyes J, et al. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Transl Psychiatry. 2017;7:e1022 pubmed publisher
    ..exposure increased A? oligomers, caused selective atrophy of hippocampal CA1 neurites, and decreased the glutamate GluR1 subunit. Wildtype C57BL/6 female mice also showed nPM-induced CA1 atrophy and GluR1 decrease...
  22. Tao W, Chen Q, Zhou W, Wang Y, Wang L, Zhang Z. Persistent inflammation-induced up-regulation of brain-derived neurotrophic factor (BDNF) promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunits in descending pain modulatory circuits. J Biol Chem. 2014;289:22196-204 pubmed publisher
    The enhanced AMPA receptor phosphorylation at GluA1 serine 831 sites in the central pain-modulating system plays a pivotal role in descending pain facilitation after inflammation, but the underlying mechanisms remain unclear...
  23. Wu H, Chen Y, Wu S, Lee C, Chen I, Lee Y, et al. Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus. Neural Plast. 2017;2017:3467805 pubmed publisher
    ..of synaptic receptors NR2B and ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1 was increased by TPPU and 14,15-EET administration...
  24. Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J. Molecular factors in migraine. Oncotarget. 2016;7:50708-50718 pubmed publisher
    ..The understanding of the molecular mechanisms of migraine, including genotype-phenotype correlations, may contribute to finding markers important for the diagnosis and treatment of this disease. ..
  25. Wang X, Zhong X, Li Z, Wang H, Zhang J, Li F, et al. Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats. BMC Neurosci. 2015;16:14 pubmed publisher
    ..The expression of N-methyl-D-aspartate (NMDA) receptor subtypes NR1 and NR2B, but not NR2A, GluR1, or GluR2 (the main subtype of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid [AMPA] receptor) in the ..
  26. Moriguchi S, Tanaka T, Tagashira H, Narahashi T, Fukunaga K. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013;242:150-7 pubmed publisher
    ..Notably, sunifiram treatment restored CaMKIIα (Thr-286) autophosphorylation and GluR1 (Ser-831) phosphorylation in the hippocampal CA1 region from OBX mice to the levels of control mice...
  27. Priya A, Johar K, Nair B, Wong Riley M. Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Biochim Biophys Acta. 2014;1843:3018-28 pubmed publisher
    ..They are heterotetrameric proteins composed of various combinations of GluA1-4 subunits, with GluA2 being the most common one...
  28. Neuner S, Wilmott L, Hoffmann B, Mozhui K, Kaczorowski C. Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. Behav Brain Res. 2017;322:288-298 pubmed publisher
    ..Overall, we provide a novel list of putative targets and pathways with therapeutic potential, including a set of proteins associated with cognitive status in normal aging mice or gene mutations that cause AD. ..
  29. Ferrara N, Cullen P, Pullins S, Rotondo E, Helmstetter F. Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination. Learn Mem. 2017;24:414-421 pubmed publisher
    ..b>GluR1 and GluR2 containing AMPA receptors are found at synapses throughout the amygdala and their expression is ..
  30. Wei I, Chen K, Tsai M, Wu C, Lane H, Huang C. Acute amino acid D-serine administration, similar to ketamine, produces antidepressant-like effects through the identical mechanisms. J Agric Food Chem. 2017;: pubmed publisher
    ..Furthermore, in addition to the increased protein kinase A phosphorylation of the AMPAR subunit GluR1 (an indicator of AMPAR insertion in neurons), treatment with individual optimal doses of D-serine and ketamine ..
  31. Yoshimura A, Numakawa T, Odaka H, Adachi N, Tamai Y, Kunugi H. Negative regulation of microRNA-132 in expression of synaptic proteins in neuronal differentiation of embryonic neural stem cells. Neurochem Int. 2016;97:26-33 pubmed publisher
    ..Inhibition of ERK1/2 activation resulted in increased levels of synaptic proteins including PSD-95, GluR1 and synapsin I. Silencing of miR-132 also increased PSD-95 and GluR1...
  32. McLaughlin D, Cheetham M, Kerwin R. Expression of alternatively-spliced glutamate receptors in human hippocampus. Eur J Pharmacol. 1993;244:89-92 pubmed
    ..We have investigated the expression of these isoforms of GluRA and GluRB in the human hippocampus...
  33. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling. ..
  34. Luo P, Yang Y, Liu W, Rao W, Bian H, Li X, et al. Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons. FEBS J. 2013;280:6114-27 pubmed publisher
    ..However, downregulation of Preso neither affected the expression of GluR1 and GluR2 nor influenced the function of ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor after ..
  35. Sun T, Wang J, Li X, Li Y, Feng D, Shi W, et al. Gastrodin relieved complete Freund's adjuvant-induced spontaneous pain by inhibiting inflammatory response. Int Immunopharmacol. 2016;41:66-73 pubmed publisher
    ..GAS administration reduced CFA-induced up-regulation of GluR1-containing ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, GluN2A- and GluN2B-containing N-..
  36. Chen A, Chen Y, Tang Y, Bao C, Cui Z, Xiao M, et al. Hippocampal AMPARs involve the central sensitization of rats with irritable bowel syndrome. Brain Behav. 2017;7:e00650 pubmed publisher
    ..The expressions of hippocampal AMPARs (GluR1 and GluR2) were determined by Western blot...
  37. Tang J, Xue W, Xia B, Ren L, Tao W, Chen C, et al. Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Sci Rep. 2015;5:13573 pubmed publisher
    ..4E-BP1 and p70S6K, their upstream regulators ERK and Akt, and downstream targets including synaptic protein GluR1. Yueju or ketamine reversed these changes at PAD 2, but only Yueju reversed phosphor-Akt at PAD 6...
  38. Santarelli S, Wagner K, Labermaier C, Uribe A, Dournes C, Balsevich G, et al. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress. 2016;19:83-90 pubmed publisher
    ..We also provide evidence that GluR1 expression in the dentate gyrus, but not GluR2 or NR1, are regulated by slc6a15 expression, and may contribute to ..
  39. Niu W, Huang X, Yu T, Chen S, Li X, Wu X, et al. No association of GRIA1 polymorphisms with schizophrenia in the Chinese Han population. Psychiatr Genet. 2016;26:97-8 pubmed publisher
  40. Mahlknecht U, Bucala R, Hoelzer D, Verdin E. High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. Cytogenet Cell Genet. 1999;86:237-9 pubmed
    ..Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband. ..
  41. Roche K, Raymond L, Blackstone C, Huganir R. Transmembrane topology of the glutamate receptor subunit GluR6. J Biol Chem. 1994;269:11679-82 pubmed
    ..In this study we have shown that both AMPA receptor subunits (GluR1-4) and kainate receptor subunits (GluR6/7) are glycosylated in adult rat brain; however, the kainate receptor ..
  42. Xia H, von Zastrow M, Malenka R. A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors. J Biol Chem. 2002;277:47765-9 pubmed
    ..assembly and surface expression, we have epitope-tagged the N-terminal domain of the AMPA receptor subunit, GluR1, and expressed it in human embryonic kidney 293 cells and hippocampal neurons...
  43. Hu R, Li L, Li D, Tan W, Wan L, Zhu C, et al. Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats. Mol Pain. 2016;12: pubmed publisher
    ..Furthermore, rescued expression of spinal Cdh1 significantly reduced surface membrane expression of GluR1, but increased the expression of GluR1-related erythropoietin-producing human hepatocellular receptor A4 and its ..
  44. Freudenberg F, Resnik E, Kolleker A, Celikel T, Sprengel R, Seeburg P. Hippocampal GluA1 expression in Gria1-/- mice only partially restores spatial memory performance deficits. Neurobiol Learn Mem. 2016;135:83-90 pubmed publisher
    ..is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1-/- mice)...
  45. Hou X, Hu Z, Zhang D, Lu W, Zhou J, Wu P, et al. Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways. Antioxid Redox Signal. 2017;27:472-488 pubmed publisher
    ..density protein 95, synaptophysin, and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor GluR1/2 subunit...
  46. Stinehelfer S, Vruwink M, Burette A. Immunolocalization of mGluR1alpha in specific populations of local circuit neurons in the cerebral cortex. Brain Res. 2000;861:37-44 pubmed
    ..Neurons staining strongly for mGluR1alpha were also positive for GluR1. These results indicated that mGluR1alpha is expressed by specific classes of GABAergic neurons in the neocortex, ..
  47. Farizatto K, McEwan S, Naidoo V, Nikas S, Shukla V, Almeida M, et al. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. J Mol Neurosci. 2017;63:115-122 pubmed publisher
    ..vulnerability evidenced by a 64% reduction in synapsin IIb (syn IIb) levels, whereas the postsynaptic protein GluR1 was unchanged...
  48. Radin D, Li Y, Rogers G, Purcell R, Lippa A. Stargazin differentially modulates ampakine gating kinetics and pharmacology. Biochem Pharmacol. 2018;148:308-314 pubmed publisher
    ..The effects of the high impact ampakines, CX614 and cyclothiazide (CTZ), were compared with homomeric GluR1-flip (Glur1i) and GluR2-flop (Glur2o) receptors expressed in HEK293 cells by transient transfection with or ..
  49. Giegling I, Drago A, Dolzan V, Plesnicar B, Schafer M, Hartmann A, et al. Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol. Pharmacogenet Genomics. 2011;21:206-16 pubmed publisher
    ..This result further stresses the relevance of the glutamatergic system in modulating the effects of haloperidol treatment, especially with regards to motor side effects. ..
  50. Kitanishi T, Ujita S, Fallahnezhad M, Kitanishi N, Ikegaya Y, Tashiro A. Novelty-Induced Phase-Locked Firing to Slow Gamma Oscillations in the Hippocampus: Requirement of Synaptic Plasticity. Neuron. 2015;86:1265-76 pubmed publisher
    ..recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in ..
  51. Fukushima A, Ogura Y, Furuta M, Kakehashi C, Funabashi T, Akema T. Ketogenic diet does not impair spatial ability controlled by the hippocampus in male rats. Brain Res. 2015;1622:36-42 pubmed publisher
    ..expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor subunit 1 (GluR1) was significantly increased in mice fed a ketogenic diet...
  52. Zou S, Li L, Pei L, Vukusic B, Van Tol H, Lee F, et al. Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity. J Neurosci. 2005;25:4385-95 pubmed
    ..These data may provide a new avenue to identify specific targets for therapeutics to modulate glutamate receptor-governed diseases, such as stroke. ..
  53. Subramanian M, Holt A, Mueller P. Physical activity correlates with glutamate receptor gene expression in spinally-projecting RVLM neurons: a laser capture microdissection study. Brain Res. 2014;1585:51-62 pubmed publisher
    ..There were no significant difference in the gene expression of NMDA (NR1, NR2A, NR2B, NR2C and NR2D), AMPA (GLUR1, GLUR2 and GLUR3) and GABAA (GABAA1 and GABAA2) receptor subunits...
  54. Zuckerman C, Blumkin E, Melamed O, Golan H. Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure. Eur Neuropsychopharmacol. 2015;25:1787-802 pubmed publisher
    ..Here we show that in utero MTHFR deficiency is sufficient to alter the levels of glutamate receptor subunits GluR1, GluR2, and NR2B in the cerebral cortex and hippocampus of adult offspring with a WT genotype...
  55. Fang J, An X, Chen S, Yu Z, Ma Q, Qu H. Case-control study of GRIA1 and GRIA3 gene variants in migraine. J Headache Pain. 2015;17:2 pubmed publisher
    ..The result provides evidence that the glutamatergic system is implicated in the pathophysiology of migraine. ..
  56. Kang W, Park J, Kim S, Park H, Lee S, Song J, et al. Genetic variants of GRIA1 are associated with susceptibility to schizophrenia in Korean population. Mol Biol Rep. 2012;39:10697-703 pubmed publisher
    ..119). These results suggest that GRIA1 polymorphism may have influence upon the risk of developing schizophrenia. ..
  57. Ge Y, Tian X, Lin Y, Liu X. Chronic treatment with levetiracetam reverses deficits in hippocampal LTP in vivo in experimental temporal lobe epilepsy rats. Neurosci Lett. 2016;628:194-200 pubmed publisher
    ..In addition, LEV treatment can alleviate the SE-induced abnormal GluR1 phosphorylation at Ser(831) site, which may contribute to the rescue of synaptic transmission...
  58. Chen P, Song J, Luo L, Cheng Q, Xiao H, Gong S. Gene expression of NMDA and AMPA receptors in different facial motor neurons. Laryngoscope. 2016;126:E6-11 pubmed publisher
    ..Messenger RNA (mRNA) of AMPAR subunits (GluR1, GluR2, GluR3, and GluR4) and NMDAR subunits (NR1, NR2a, NR2b, NR2c, and NR2d) was detected in reinnervating and ..
  59. Wang W, Wang X, Chen L, Zhang Y, Xu Z, Liu J, et al. The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity. Expert Rev Mol Med. 2016;18:e4 pubmed publisher
    ..Immunoprecipitation studies confirmed that the CREB1 antibody effectively precipitated CREB1 and NMDAR1 but not GLUR1 from rat brain hippocampus...
  60. Sanderson D, Lee A, Sprengel R, Seeburg P, Harrison P, Bannerman D. Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia. Sci Rep. 2017;7:1765 pubmed publisher
    The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience...
  61. Austen J, Sprengel R, Sanderson D. GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact. Sci Rep. 2017;7:7424 pubmed publisher
    The GluA1 subunit of the AMPA receptor has been implicated in schizophrenia...
  62. Yakel J, Vissavajjhala P, Derkach V, Brickey D, Soderling T. Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors. Proc Natl Acad Sci U S A. 1995;92:1376-80 pubmed
    ..CaM-kinase II enhanced kainate currents of expressed glutamate receptor 6 in 293 cells and of wild-type glutamate receptor 1, but not the Ser-627 to Ala mutant, in Xenopus oocytes...
  63. Kessels H, Malinow R. Synaptic AMPA receptor plasticity and behavior. Neuron. 2009;61:340-50 pubmed publisher
    ..We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models. ..
  64. Chiesa A, Crisafulli C, Porcelli S, Han C, Patkar A, Lee S, et al. Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder. Eur Arch Psychiatry Clin Neurosci. 2012;262:305-11 pubmed publisher
  65. Brooks I, Tavalin S. Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. J Biol Chem. 2011;286:6697-706 pubmed publisher
    GluA1 (formerly GluR1) AMPA receptor subunit phosphorylation at Ser-831 is an early biochemical marker for long-term potentiation and learning...
  66. Walter S, Atzmon G, Demerath E, Garcia M, Kaplan R, Kumari M, et al. A genome-wide association study of aging. Neurobiol Aging. 2011;32:2109.e15-28 pubmed publisher
    ..These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity. ..
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