GLIS3

Summary

Gene Symbol: GLIS3
Description: GLIS family zinc finger 3
Alias: NDH, ZNF515, zinc finger protein GLIS3, GLI-similar 3, OK/KNS-cl.4, zinc finger protein 515
Species: human
Products:     GLIS3

Top Publications

  1. Senée V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec J, et al. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet. 2006;38:682-7 pubmed
    ..Here, we show that this syndrome results from mutations in GLIS3, encoding GLI similar 3, a recently identified transcription factor...
  2. Kim Y, Nakanishi G, Lewandoski M, Jetten A. GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res. 2003;31:5513-25 pubmed
    In this study, we describe the identification and characterization of a novel transcription factor GLI-similar 3 (GLIS3). GLIS3 is an 83...
  3. Barker A, Sharp S, Timpson N, Bouatia Naji N, Warrington N, Kanoni S, et al. Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011;60:1805-12 pubmed publisher
    ..with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2)...
  4. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
    ..These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1)...
  5. Liu C, Li H, Qi L, Loos R, Qi Q, Lu L, et al. Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans. PLoS ONE. 2011;6:e21464 pubmed publisher
    ..We genotyped nine variants in or near MADD, ADRA2A, CRY2, GLIS3, PROX1, FADS1, C2CD4B, IGF1 and IRS1 in a population-based cohort including 3,210 unrelated Chinese Hans from ..
  6. Li H, Gan W, Lu L, Dong X, Han X, Hu C, et al. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes. 2013;62:291-8 pubmed publisher
    ..Besides confirming seven established T2D loci (CDKAL1, CDKN2A/B, KCNQ1, CDC123, GLIS3, HNF1B, and DUSP9) at genome-wide significance, we identified two novel T2D loci, including G-protein-coupled ..
  7. Cho Y, Chen C, Hu C, Long J, Ong R, Sim X, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011;44:67-72 pubmed publisher
    ..The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3...
  8. Boesgaard T, Grarup N, Jørgensen T, Borch Johnsen K, Hansen T, Pedersen O. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. Diabetologia. 2010;53:1647-55 pubmed publisher
    ..Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the population-based Inter99 cohort...
  9. Nikiforova M, Nikitski A, Panebianco F, Kaya C, Yip L, Williams M, et al. GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. Thyroid. 2019;: pubmed publisher
    ..RNA-Seq results were used for pathway analysis. Tissue expression of GLIS3 and other proteins was detected by immunohistochemistry...

More Information

Publications70

  1. Hall E, Volkov P, Dayeh T, Bacos K, Rönn T, Nitert M, et al. Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets. BMC Med. 2014;12:103 pubmed publisher
    ..These include candidate genes for T2D, such as TCF7L2, GLIS3, HNF1B and SLC30A8...
  2. Huang L, Chen Y, Lin Y, Tam P, Cheng Y, Shi Y, et al. Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population. Sci China Life Sci. 2019;62:153-164 pubmed publisher
    ..2, ETV1/DGKB), rs548030386 (7q31.2, ST7 near CAV1/CAV2), rs7047871 (9p24.2, GLIS3), and rs2472494 (9q31.1, ABCA1/SLC44A1)...
  3. Yang Y, Chang B, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013;5:92-104 pubmed publisher
    Genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 and type 2 diabetes. Global Glis3 deficiency in mice leads to congenital diabetes and neonatal lethality...
  4. Fu C, Luo S, Zhang Y, Fan X, D Gama A, Zhang X, et al. Chromosomal microarray and whole exome sequencing identify genetic causes of congenital hypothyroidism with extra-thyroidal congenital malformations. Clin Chim Acta. 2019;489:103-108 pubmed publisher
    ..a syndromic diagnosis, and the remaining patient carried a pathogenic microdeletion and microduplication including GLIS3. WES analysis identified 9 different variants in 7 additional patients. The variants included 2 known mutations (c...
  5. Park S, Alfa R, Topper S, Kim G, Kockel L, Kim S. A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion. PLoS Genet. 2014;10:e1004555 pubmed publisher
    ..Knockdown of the Drosophila orthologues of human T2DM risk genes, including GLIS3 and BCL11A, revealed roles of these Drosophila genes in Ilp2 production or secretion...
  6. Ungewitter E, Rotgers E, Kang H, Lichti Kaiser K, Li L, Grimm S, et al. Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis. Sci Rep. 2018;8:9662 pubmed publisher
    ..Here we identify a novel role for the Krüppel-like transcription factor Gli-Similar 3 (Glis3) in male germ cell development in the mouse embryos...
  7. Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, et al. Discovery of a drug candidate for GLIS3-associated diabetes. Nat Commun. 2018;9:2681 pubmed publisher
    b>GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology...
  8. Ji Q, Qi D, Xu X, Xu Y, Goodman S, Kang L, et al. Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis. Mol Ther Nucleic Acids. 2018;11:170-179 pubmed publisher
    ..In addition, miR-106a-5p inhibited GLI-similar 3 (GLIS3) production by directly targeting the 3' untranslated region...
  9. Ding M, Chavarro J, Olsen S, Lin Y, Ley S, Bao W, et al. Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations. Diabetologia. 2018;61:1758-1768 pubmed publisher
    ..For the first time, we identified eight variants associated with GDM, namely rs7957197 (HNF1A), rs10814916 (GLIS3), rs3802177 (SLC30A8), rs9379084 (RREB1), rs34872471 (TCF7L2), rs7903146 (TCF7L2), rs11787792 (GPSM1) and ..
  10. Kiani A, John P, Bhatti A, Zia A, Shahid G, Akhtar P, et al. Association of 32 type 1 diabetes risk loci in Pakistani patients. Diabetes Res Clin Pract. 2015;108:137-42 pubmed publisher
    ..01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more ..
  11. Barrett J, Clayton D, Concannon P, Akolkar B, Cooper J, Erlich H, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009;41:703-7 pubmed publisher
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
  12. De Vas M, Kopp J, Heliot C, Sander M, Cereghini S, Haumaitre C. Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015;142:871-82 pubmed publisher
    ..Notably, we show that Glis3, a transcription factor involved in duct morphogenesis and endocrine cell development, is downstream Hnf1b...
  13. Steck A, Dong F, Wong R, Fouts A, Liu E, Romanos J, et al. Improving prediction of type 1 diabetes by testing non-HLA genetic variants in addition to HLA markers. Pediatr Diabetes. 2014;15:355-62 pubmed
    ..87, 1.55, and 1.54, respectively, all p ? 0.003], while GLIS3 and IL2RA showed borderline association with development of IA...
  14. Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, et al. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012;16:435-48 pubmed publisher
    ..Depletion of HI-LNC25, a β cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs...
  15. Hong K, Kim S, Zhang X, Park S. Interactions among the variants of insulin-related genes and nutrients increase the risk of type 2 diabetes. Nutr Res. 2018;51:82-92 pubmed publisher
    ..The best model included six SNPs, FNBP1L-rs4847428, FNBP1L-rs23766, GLIS3-rs2027393, GLIS3-rs3892354, GLIS3-rs486163 and DLC1-rs17093957...
  16. Jetten A. GLIS1-3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases. Cell Mol Life Sci. 2018;75:3473-3494 pubmed publisher
    ..b>GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic ? ..
  17. Kim Y, Kang H, Takeda Y, Hom L, Song H, Jensen J, et al. Glis3 regulates neurogenin 3 expression in pancreatic β-cells and interacts with its activator, Hnf6. Mol Cells. 2012;34:193-200 pubmed publisher
    The Krüppel-like zinc finger transcription factor, Glis3, has been associated with neonatal diabetes in humans and mice, and implicated in the regulation of pancreatic β-cell generation...
  18. Duarte G, Assmann T, Dieter C, de Souza B, Crispim D. GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus. Acta Diabetol. 2017;54:813-821 pubmed publisher
    The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta cells as well as in the regulation of Insulin gene expression in adults...
  19. Kang H, Chen L, Lichti Kaiser K, Liao G, Gerrish K, Bortner C, et al. Transcription Factor GLIS3: A New and Critical Regulator of Postnatal Stages of Mouse Spermatogenesis. Stem Cells. 2016;34:2772-2783 pubmed publisher
    ..we identify a novel and essential role for the Krüppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) in the regulation of postnatal spermatogenesis...
  20. Cao B, Gong C, Wu D, Lu C, Liu F, Liu X, et al. Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China. J Diabetes Res. 2016;2016:6314368 pubmed publisher
    ..There were six non-KATP mutations, five novel mutations, including INS, EIF2AK3 (n = 2), GLIS3, and SLC19A2, one known EIF2AK3 mutation. There are two ABCC8 mutations in TNDM cases and one paternal UPD6q24...
  21. Shakhtshneider E, Mikhaĭlova S, Ivanoshchuk D, Orlov P, Ovsyannikova A, Rymar O, et al. Polymorphism of the GLIS3 gene in a Caucasian population and among individuals with carbohydrate metabolism disorders in Russia. BMC Res Notes. 2018;11:211 pubmed publisher
    Earlier, GLIS3 gene polymorphisms have been shown to be associated with the development of maturity onset diabetes of the young (MODY)...
  22. Sanchez Castro M, Eldjouzi H, Charpentier E, Busson P, Hauet Q, Lindenbaum P, et al. Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta. Circ Cardiovasc Genet. 2016;9:86-94 pubmed publisher
    ..candidate genes for congenital heart defects within these CNVs, including BTRC, CHRNB3, CSRP2BP, ERBB2, ERMARD, GLIS3, PLN, PTPRJ, RLN3, and TCTE3...
  23. Zhu Z, Li Q, Lee K, Rosen B, González F, Soh C, et al. Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell. 2016;18:755-68 pubmed publisher
    ..for a systematic analysis of the roles of eight pancreatic transcription factors (PDX1, RFX6, PTF1A, GLIS3, MNX1, NGN3, HES1, and ARX)...
  24. Kang H, Takeda Y, Jeon K, Jetten A. The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PLoS ONE. 2016;11:e0157138 pubmed publisher
    The transcription factor Glis-similar 3 (Glis3) has been implicated in the development of neonatal, type 1 and type 2 diabetes...
  25. Fan X, Fu C, Shen Y, Li C, Luo S, Li Q, et al. Next-generation sequencing analysis of twelve known causative genes in congenital hypothyroidism. Clin Chim Acta. 2017;468:76-80 pubmed publisher
    ..1, NKX2.5, FOXE1, DUOX2, TG, TPO, GLIS3, NIS, SLC26A4 and DEHAL1) in CH in China. Peripheral venous blood samples were collected from the patients...
  26. Alghamdi K, Alsaedi A, AlJasser A, Altawil A, Kamal N. Extended clinical features associated with novel Glis3 mutation: a case report. BMC Endocr Disord. 2017;17:14 pubmed publisher
    Mutations in the GLI-similar 3 (GLIS3) gene encoding the transcription factor GLIS3 are a rare cause of neonatal diabetes and congenital hypothyroidism with 12 reported patients to date...
  27. Wakil S, Ram R, Muiya N, Andres E, Mazhar N, Hagos S, et al. A common variant association study reveals novel susceptibility loci for low HDL-cholesterol levels in ethnic Arabs. Clin Genet. 2016;90:518-525 pubmed publisher
    ..Seven other variants including rs1147169 in the PLCL1 gene, rs10248618 in the DNAH11, rs476155 in the GLIS3, rs7024300 in the ABCA1, intergenic rs10836699, rs11603691 in P2RX3 and rs750134 in CORO1C gene exhibited ..
  28. Nongpiur M, Cheng C, Duvesh R, Vijayan S, Baskaran M, Khor C, et al. Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. Ophthalmology. 2018;125:664-670 pubmed publisher
    ..rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
  29. Yang Y, Bush S, Wen X, Cao W, Chan L. Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic ? Cell Differentiation and Function. Endocrinology. 2017;158:9-20 pubmed publisher
    Mutations of GLI-similar 3 (GLIS3) underlie a neonatal diabetes syndrome. Genome-wide association studies revealed that GLIS3 variants are associated with both common type 1 and type 2 diabetes...
  30. Chung S, Kim M, Kim J, Ryu H, Kim Y, Kim S, et al. Association of type 2 diabetes GWAS loci and the risk of Parkinson's and Alzheimer's diseases. Parkinsonism Relat Disord. 2015;21:1435-40 pubmed publisher
    ..We selected 32 genetic variants from 11 genes (CDC123, CDKAL1, CDKN2B, FTO, GLIS3, HHEX, IGF2BP2, KCNJ11, KCNQ1, SLC30A8, and TCF7L2) and intergenic regions based on results of recent genome-wide ..
  31. Dou H, Wang Y, Yang N, Heng M, Zhou X, Bu H, et al. Association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study. Chin J Integr Med. 2017;23:415-424 pubmed publisher
    ..case-control study was performed to investigate the association between common variants in four genes (CDKAL1, GLIS3, GRK5, and TCF7L2) and symptoms of T2DM. Symptoms were examined with questionnaire for 710 subjects...
  32. Johansson S, Irgens H, Chudasama K, Molnes J, Aerts J, Roque F, et al. Exome sequencing and genetic testing for MODY. PLoS ONE. 2012;7:e38050 pubmed publisher
    ..Novel variants in the genes ARAP1, GLIS3, MADD, NOTCH2 and WFS1 need further investigation to reveal their possible role in diabetes...
  33. Khor C, Do T, Jia H, Nakano M, George R, Abu Amero K, et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016;48:556-62 pubmed publisher
    ..24, p = 5.94 × 10(-15)), chat rs1258267 (or = 1.22, p = 2.85 × 10(-16)), glis3 rs736893 (or = 1.18, p = 1.43 × 10(-14)), fermt2 rs7494379 (or = 1.14, p = 3...
  34. Zeruth G, Williams J, Cole Y, Jetten A. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS ONE. 2015;10:e0131303 pubmed publisher
    The transcription factor Gli-similar 3 (Glis3) plays a critical role in the generation of pancreatic ß cells and the regulation insulin gene transcription and has been implicated in the development of several pathologies, including ..
  35. Lee S, Noh H, Kim H, Lee K, Hwang D. Glis family proteins are differentially implicated in the cellular reprogramming of human somatic cells. Oncotarget. 2017;8:77041-77049 pubmed publisher
    ..However, the implication of other Glis members, including Glis2 and Glis3 (variants 1 and 2), in cellular reprogramming remains unknown...
  36. Kang H, Kumar D, Liao G, Lichti Kaiser K, Gerrish K, Liao X, et al. GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation. J Clin Invest. 2017;127:4326-4337 pubmed publisher
    Deficiency in Krüppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) in humans is associated with the development of congenital hypothyroidism...
  37. Rasouly H, Kumar S, Chan S, Pisarek Horowitz A, Sharma R, Xi Q, et al. Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016;90:1262-1273 pubmed publisher
    ..At the molecular level, Zeb2 deletion caused aberrant expression of Pkd1, Hnf1β, and Glis3, three genes causing glomerular cysts...
  38. Cruchaga C, Kauwe J, Harari O, Jin S, Cai Y, Karch C, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 2013;78:256-68 pubmed publisher
    ..07 × 10⁻⁸ and p = 3.22 × 10⁻⁹ for tau and ptau, respectively), located at 9p24.2 within GLIS3 and rs6922617 (p = 3.58 × 10⁻⁸ for CSF ptau) at 6p21...
  39. Li L, Chen S, Wang Q, Wu C, Wen X, Yang F, et al. GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population. Genet Test Mol Biomarkers. 2017;21:565-570 pubmed publisher
    ..Single nucleotide polymorphisms (SNPs) in the GLI-similar 3 (GLIS3) and tyrosine kinase 2 (TYK2) genes have been associated with various autoimmune diseases...
  40. Scoville D, Kang H, Jetten A. GLIS1-3: emerging roles in reprogramming, stem and progenitor cell differentiation and maintenance. Stem Cell Investig. 2017;4:80 pubmed publisher
    ..b>GLIS3 plays a critical role during the development of several tissues...
  41. Grant S, Qu H, Bradfield J, Marchand L, Kim C, Glessner J, et al. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes. 2009;58:290-5 pubmed publisher
    ..The two genes at these respective loci, UBASH3A and BACH2, are both biologically relevant to autoimmunity. ..
  42. Awata T, Yamashita H, Kurihara S, Morita Ohkubo T, Miyashita Y, Katayama S, et al. A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes. Biochem Biophys Res Commun. 2013;437:521-5 pubmed publisher
    ..The association analysis of the low-frequency variants revealed that only the A908V variant of GLIS3 was strongly associated with resistance to T1D (Haldane's odds ratio = 0.046, p = 8.21 × 10(-4), and pc=2...
  43. Calderari S, Ria M, Gerard C, Nogueira T, Villate O, Collins S, et al. Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Genomics. 2018;110:98-111 pubmed publisher
    The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0...
  44. Muller Y, Piaggi P, Chen P, Wiessner G, Okani C, Kobes S, et al. Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3. Diabetes Metab Res Rev. 2017;33: pubmed publisher
    ..Tag SNPs within FITM2-R3HDML-HNF4A, GLIS3, KCNK16, and ZFAND3 associated with T2DM after accounting for locus-wide multiple testing...
  45. Zeruth G, Yang X, Jetten A. Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. J Biol Chem. 2011;286:22077-89 pubmed publisher
    b>Glis3 is a member of the Glis subfamily of Krüppel-like zinc finger transcription factors. Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively regulate insulin gene expression...
  46. Treviño L, Shimasaki N, Yang W, Panetta J, Cheng C, Pei D, et al. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009;27:5972-8 pubmed publisher
    ..4; P = .03 to .004). A genome-wide interrogation identified inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as important determinants of methotrexate's pharmacokinetics and clinical effects. ..
  47. Permuth J, Chen D, Yoder S, Li J, Smith A, Choi J, et al. Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Sci Rep. 2017;7:10484 pubmed publisher
    ..An 8-lncRNA signature (including ADARB2-AS1, ANRIL, GLIS3-AS1, LINC00472, MEG3, PANDA, PVT1, and UCA1) had greater accuracy than standard clinical and radiologic features ..
  48. Wiggs J, Pasquale L. Genetics of glaucoma. Hum Mol Genet. 2017;26:R21-R27 pubmed publisher
    ..PMM2, TGFBR3, FNDC3B, ARHGEF12, GAS7, FOXC1, ATXN2, TXNRD2); PACG (primary angle-closure glaucoma (EPDR1, CHAT, GLIS3, FERMT2, DPM2-FAM102); and exfoliation syndrome (XFS) glaucoma (CACNA1A)...
  49. Dooley J, Tian L, Schonefeldt S, Delghingaro Augusto V, Garcia Perez J, Pasciuto E, et al. Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet. 2016;48:519-27 pubmed publisher
    ..Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates...
  50. Fu C, Luo S, Long X, Li Y, She S, Hu X, et al. Mutation screening of the GLIS3 gene in a cohort of 592 Chinese patients with congenital hypothyroidism. Clin Chim Acta. 2018;476:38-43 pubmed publisher
    Defects in the human GLI-similar 3 (GLIS3) gene are reported to be a rare cause of congenital hypothyroidism (CH) and neonatal diabetes...
  51. Rees S, Hydrie M, O Hare J, Kumar S, Shera A, Basit A, et al. Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS ONE. 2011;6:e24710 pubmed publisher
    ..to previously reported type 2 diabetes risk variants in TCF7L2 and SLC30A8, SNPs in ADCY5 (rs11708067) and GLIS3 (rs7034200) displayed evidence for association with type 2 diabetes, with odds ratios of 1.23 (95% CI: 1.09, 1...
  52. Dimitri P. The role of GLIS3 in thyroid disease as part of a multisystem disorder. Best Pract Res Clin Endocrinol Metab. 2017;31:175-182 pubmed publisher
    ..diabetes and congenital hypothyroidism was first reported in 2003 and subsequently led to the identification GLIS3 as the mutation responsible for this presentation...
  53. Dimitri P, De Franco E, Habeb A, Gurbuz F, Moussa K, Taha D, et al. An emerging, recognizable facial phenotype in association with mutations in GLI-similar 3 (GLIS3). Am J Med Genet A. 2016;170:1918-23 pubmed publisher
    ..Mutations in the transcription factor GLI-similar 3 (GLIS3) gene in the original family and two other families were subsequently reported in 2006...
  54. Wen X, Yang Y. Emerging roles of GLIS3 in neonatal diabetes, type 1 and type 2 diabetes. J Mol Endocrinol. 2017;58:R73-R85 pubmed publisher
    GLI-similar 3 (GLIS3), a member of the Krüppel-like zinc finger protein subfamily, is predominantly expressed in the pancreas, thyroid and kidney. Glis3 mRNA can be initially detected in mouse pancreas at embryonic day 11...
  55. Qu H, Bradfield J, Li Q, Kim C, Frackelton E, Grant S, et al. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. Hum Mol Genet. 2010;19:2534-8 pubmed publisher
    ..This study replicated T1D association with at least as many of these novel loci as expected from the power of our sample size, thus supporting the validity of the new discoveries. ..
  56. Hwang J, Sim X, Wu Y, Liang J, Tabara Y, Hu C, et al. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes. 2015;64:291-8 pubmed publisher
    ..Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. ..
  57. Nogueira T, Paula F, Villate O, Colli M, Moura R, Cunha D, et al. GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet. 2013;9:e1003532 pubmed publisher
    Mutations in human Gli-similar (GLIS) 3 protein cause neonatal diabetes. The GLIS3 gene region has also been identified as a susceptibility risk locus for both type 1 and type 2 diabetes...
  58. Chou C, Tang C, Chou H, Liu C, Ng M, Chang Y, et al. The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers. Arch Immunol Ther Exp (Warsz). 2017;65:381-389 pubmed publisher
    Gli-similar 3 (Glis3) belongs to a Glis subfamily of Krüppel-like zinc-finger transcription factors characterized to regulate a set of downstream targets essential for cellular functions, including pancreatic development, ?-cell ..
  59. Xu L, Hazard F, Zmoos A, Jahchan N, Chaib H, Garfin P, et al. Genomic analysis of fibrolamellar hepatocellular carcinoma. Hum Mol Genet. 2015;24:50-63 pubmed publisher
    ..The second gene fusion event, a translocation between the CLPTM1L and GLIS3 genes, generates a transcript whose product also promotes cancer phenotypes in HCC cell lines...
  60. Juan Mateu J, Alvelos M, Turatsinze J, Villate O, Lizárraga Mollinedo E, Grieco F, et al. SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival. Diabetes. 2018;67:423-436 pubmed publisher
    ..Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility gene GLIS3, has a major role in maintaining the function and survival of human β-cells...
  61. Dimitri P, Habeb A, Gurbuz F, Garbuz F, Millward A, Wallis S, et al. Expanding the Clinical Spectrum Associated With GLIS3 Mutations. J Clin Endocrinol Metab. 2015;100:E1362-9 pubmed publisher
    b>GLIS3 (GLI-similar 3) is a member of the GLI-similar zinc finger protein family encoding for a nuclear protein with 5 C2H2-type zinc finger domains...