Gene Symbol: GLI2
Description: GLI family zinc finger 2
Alias: CJS, HPE9, PHS2, THP1, THP2, zinc finger protein GLI2, GLI family zinc finger protein 2, GLI-Kruppel family member GLI2, glioma-associated oncogene family zinc finger 2, oncogene GLI2, tax helper protein 1, tax helper protein 2, tax-responsive element-2 holding protein, tax-responsive element-25-bp sequence binding protein
Species: human
Products:     GLI2

Top Publications

  1. Tanimura A, Dan S, Yoshida M. Cloning of novel isoforms of the human Gli2 oncogene and their activities to enhance tax-dependent transcription of the human T-cell leukemia virus type 1 genome. J Virol. 1998;72:3958-64 pubmed
    ..Here we report novel forms of the human homolog of a member of the Gli oncogene family, Gli2 (also termed Gli2/THP), an extended form of a zinc finger protein, THP, which was described previously...
  2. Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K. Physical and functional interactions between Zic and Gli proteins. J Biol Chem. 2001;276:6889-92 pubmed
  3. Roessler E, Du Y, Mullor J, Casas E, Allen W, Gillessen Kaesbach G, et al. Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features. Proc Natl Acad Sci U S A. 2003;100:13424-9 pubmed
    ..b>Gli2 is one of three vertebrate transcription factors implicated as obligatory mediators of Shh signal transduction...
  4. Roessler E, Ermilov A, Grange D, Wang A, Grachtchouk M, Dlugosz A, et al. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet. 2005;14:2181-8 pubmed
    Zinc finger-containing Gli proteins mediate responsiveness to Hedgehog (Hh) signaling, with Gli2 acting as the major transcriptional activator in this pathway in mice...
  5. Regl G, Neill G, Eichberger T, Kasper M, Ikram M, Koller J, et al. Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Oncogene. 2002;21:5529-39 pubmed
    ..keratinocytes, we identified a positive feedback mechanism involving the zinc finger transcription factors GLI1 and GLI2. Expression of GLI1 in human keratinocytes induced the transcriptional activator isoforms GLI2alpha and GLI2beta...
  6. Dennler S, Andre J, Alexaki I, Li A, Magnaldo T, Ten Dijke P, et al. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007;67:6981-6 pubmed
    ..Herein, we show that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal fibroblasts and keratinocytes, as well as various cancer cell lines...
  7. Thiyagarajan S, Bhatia N, Reagan Shaw S, Cozma D, Thomas Tikhonenko A, Ahmad N, et al. Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Res. 2007;67:10642-6 pubmed
    ..The GLI2 transcription factor is a primary mediator of Hh signaling...
  8. Kump E, Ji J, Wernli M, Hausermann P, Erb P. Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis. Oncogene. 2008;27:3856-64 pubmed publisher
    ..Uncontrolled Hedgehog signaling leads to overexpression of the zinc-finger Gli transcription factors, among which Gli2 plays a central role...
  9. Narita S, So A, Ettinger S, Hayashi N, Muramaki M, Fazli L, et al. GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer. Clin Cancer Res. 2008;14:5769-77 pubmed publisher
    ..The objectives of this study were to characterize GLI2 expression levels in human prostate cancer cell lines and tissues to test the effect of antisense oligonucleotide (..

More Information

Publications104 found, 100 shown here

  1. Lin M, Guo L, Liu H, Du J, Yang J, Zhang L, et al. Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma. Histol Histopathol. 2010;25:1269-75 pubmed publisher
    ..role of Gli in the development and progression of hepatocellular carcinoma (HCC), we investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell ..
  2. Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui C. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 1998;20:54-7 pubmed
    ..In mice, three zinc-finger transcription factors, Gli1, Gli2 and Gli3, have been implicated in the transduction of Shh signal...
  3. Browning C, Smith M, Clark N, Lane B, Parada C, Montano M, et al. Human GLI-2 is a tat activation response element-independent Tat cofactor. J Virol. 2001;75:2314-23 pubmed
    ..These findings link the GLI family of transcriptional and developmental regulatory proteins to Tat function and HIV replication. ..
  4. Ikram M, Neill G, Regl G, Eichberger T, Frischauf A, Aberger F, et al. GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol. 2004;122:1503-9 pubmed
    ..Deregulation of the Shh pathway is associated with basal cell carcinoma (BCC) due to upregulation of GLI1 and GLI2. We recently demonstrated a positive feedback loop between GLI1 and GLI2, which revealed that GLI1 may be a direct ..
  5. Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C, et al. Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics. 2006;87:616-32 pubmed
    ..Basal cell carcinoma can be caused by overexpression of either GLI1 or GLI2. Though GLI1 and GLI2 have identical or very similar DNA binding specificities, some of their activities are ..
  6. Bhatia N, Thiyagarajan S, Elcheva I, Saleem M, Dlugosz A, Mukhtar H, et al. Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. J Biol Chem. 2006;281:19320-6 pubmed
    ..The transcription factor Gli2 plays a key role in the transduction of Hh signals by modulating transcription of some Hh target genes, yet the ..
  7. Zhang D, Cao L, Li Y, Lu H, Yang X, Xue P. Expression of glioma-associated oncogene 2 (Gli 2) is correlated with poor prognosis in patients with hepatocellular carcinoma undergoing hepatectomy. World J Surg Oncol. 2013;11:25 pubmed publisher
    ..The aim of this study was to explore the clinical significance of Gli2 expression in HCC...
  8. Kinzler K, Ruppert J, Bigner S, Vogelstein B. The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature. 1988;332:371-4 pubmed
    ..The link between the developmentally important Kruppel family of genes and GLI is interesting considering the similarities between developing embryonic and neoplastic tissue. ..
  9. Dan S, Tanimura A, Yoshida M. Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein. J Virol. 1999;73:3258-63 pubmed
    ..of 21-bp sequence, we examined protein binding to the DNA elements by DNA affinity precipitation assay including Gli2 protein binding to TRE2S and CREB protein binding to 21-bp sequence...
  10. Stone D, Murone M, Luoh S, Ye W, Armanini M, Gurney A, et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci. 1999;112 ( Pt 23):4437-48 pubmed
    ..transcription factor Gli, which mediates Hedgehog signaling in vertebrates, and to physically interact with Gli, Gli2 and Gli3 as well as with Slimb, an F-box containing protein which, in the fly, suppresses the Hedgehog response, in ..
  11. Regl G, Kasper M, Schnidar H, Eichberger T, Neill G, Ikram M, et al. The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene. 2004;23:1263-74 pubmed
    ..The zinc-finger transcription factor Gli2 has been identified as critical mediator of the Hh signal at the distal end of the pathway, but the molecular ..
  12. Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, et al. GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem. 2008;283:12426-37 pubmed publisher
    Hedgehog (HH) signaling in the epidermis is primarily mediated by the zinc finger transcription factors GLI1 and GLI2. Exquisite regulation of HH/GLI signaling is crucial for proper specification of the epidermal lineage and development ..
  13. Snijders A, Huey B, Connelly S, Roy R, Jordan R, Schmidt B, et al. Stromal control of oncogenic traits expressed in response to the overexpression of GLI2, a pleiotropic oncogene. Oncogene. 2009;28:625-37 pubmed publisher
    Hedgehog signaling is often activated in tumors, yet it remains unclear how GLI2, a transcription factor activated by this pathway, acts as an oncogene. We show that GLI2 is a pleiotropic oncogene...
  14. Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, et al. Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nat Cell Biol. 2010;12:132-42 pubmed publisher
    ..We show here that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains ..
  15. Alexaki V, Javelaud D, Van Kempen L, Mohammad K, Dennler S, Luciani F, et al. GLI2-mediated melanoma invasion and metastasis. J Natl Cancer Inst. 2010;102:1148-59 pubmed publisher
    ..Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional target of TGF-beta signaling...
  16. Zhang D, Liu J, Wang Y, Chen J, Chen T. shRNA-mediated silencing of Gli2 gene inhibits proliferation and sensitizes human hepatocellular carcinoma cells towards TRAIL-induced apoptosis. J Cell Biochem. 2011;112:3140-50 pubmed publisher
    ..As a key effector of this signaling, Gli2 plays a crucial role in carcinogenesis, including the activation of genes encoding apoptosis inhibitors and cell-..
  17. Kotla S, Singh N, Kirchhofer D, Rao G. Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. J Biol Chem. 2017;292:14885-14901 pubmed publisher
    ..15-LOXs 1 and 2, induced TF expression and activity in a time-dependent manner in the human monocytic cell line THP1. Moreover, TF suppression with neutralizing antibodies blocked 15(S)-HETE-induced monocyte migration...
  18. Fan J, Liu D, He C, Li X, He F. Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. J Ethnopharmacol. 2016;192:423-430 pubmed publisher
    ..oxidized low density lipoprotein (oxLDL)-induced VCAM-1 and p38 protein expression and THP1 cell adhesion to ECs were assessed after treatment with PNS or Rb1...
  19. Regdon Z, Robaszkiewicz A, Kovacs K, Rygielska Ż, Hegedus C, Bodoor K, et al. LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis. Free Radic Biol Med. 2019;131:184-196 pubmed publisher
    ..The importance of this event was confirmed by overexpression of PARP1 in THP1 cells using a viral promoter, which lead to stable PARP1 levels even after LPS treatment and unresponsiveness to ..
  20. Gao Y, Fang X, Vincent D, Threadgill D, Bartholin L, Li Q. Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reprod Biol Endocrinol. 2017;15:94 pubmed publisher
    ..cell compartment during ovarian pathogenesis in TGFBR1-CAG9Cre mice, along with upregulation of Gli1 and Gli2 and downregulation of Tgfbr3 in ovarian tumor tissues...
  21. Russell R, McDonald J, Lambert L, Tregoning J. Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice. J Virol. 2016;90:4735-4744 pubmed publisher
    ..In vitro, these compounds induced an interleukin 1-beta (IL-1β) response in the macrophage-like cell line THP1.In vivo, adult CB6F1 female mice were immunized intramuscularly with H1N1 influenza vaccine antigens in combination ..
  22. Lei Q, Li L, Cai J, Huang W, Qin B, Zhang S. ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway. Viral Immunol. 2016;29:105-11 pubmed publisher
    ..granulocyte macrophage colony-stimulating factor (GM-CSF)] in lipopolysaccharide (LPS)-stimulated human PMA-THP1 cells...
  23. Pollard D, Berger C, So E, Yu L, Hadavizadeh K, Jennings P, et al. Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ. MBio. 2018;9: pubmed publisher polarized Caco2 cells, EspJ targeted Src and Csk and the Src family kinase (SFK) Yes1, while in differentiated Thp1 cells, EspJ modified Csk, the SFKs Hck and Lyn, the Tec family kinases Tec and Btk, and the adapter tyrosine kinase ..
  24. Rychli K, Grunert T, Ciolacu L, Zaiser A, Razzazi Fazeli E, Schmitz Esser S, et al. Exoproteome analysis reveals higher abundance of proteins linked to alkaline stress in persistent Listeria monocytogenes strains. Int J Food Microbiol. 2016;218:17-26 pubmed publisher
    ..Invasion efficiency of EGDe was higher in intestinal epithelial Caco2 and macrophage-like THP1 cells compared to the persistent strains...
  25. Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, et al. Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation. J Biol Chem. 2018;293:2546-2557 pubmed publisher
    ..bone marrow-derived macrophages (BMDM) isolated from wildtype (wt) or CSE-deficient mice and human macrophages (THP1 cells and primary macrophages), were stimulated with MSU crystals in the presence or absence of a H2S ..
  26. Li K, Wei L, Huang Y, Wu Y, Su M, Pang X, et al. Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion. Int J Oncol. 2016;48:2479-87 pubmed publisher
    ..b>THP1 cells were used to differentiate M2 polarization macrophages...
  27. He J, Zhang G, Pang Q, Yu C, Xiong J, Zhu J, et al. SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. FEBS J. 2017;284:1324-1337 pubmed publisher
    ..the key autophagy initiation gene ATG5, reversed the autophagy-promoting effect of SIRT6 in ox-LDL-treated THP1 cells, as evidenced by an increase in foam cells...
  28. Murphy A, Thomas A, Crinion S, Kent B, Tambuwala M, Fabre A, et al. Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation. Eur Respir J. 2017;49: pubmed publisher
    ..Complimentary in vitro analysis demonstrated that IH led to M1 polarisation of THP1-derived macrophages...
  29. Zhang X, Liu X, Ge X, Fen L, Wang X. [Expression and clinical significances of hedgehog signaling pathway in non-Hodgkin's lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:1129-33 pubmed
    This study was aimed to investigate the expression and clinicopathologic significance of Gli1 and Gli2, 2 factors of Hedgehog(Hh) signaling pathway, in non-Hodgkin's lymphoma (NHL)...
  30. Tang Y, Gholamin S, Schubert S, Willardson M, Lee A, Bandopadhayay P, et al. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014;20:732-40 pubmed publisher
    ..suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule ..
  31. Jain S, Jacob M, Walker L, Tekwani B. Screening North American plant extracts in vitro against Trypanosoma brucei for discovery of new antitrypanosomal drug leads. BMC Complement Altern Med. 2016;16:131 pubmed publisher
    ..4 ?g/mL. Active extracts were also investigated for toxicity in Differentiated THP1 cells at 10 ?g/mL concentration...
  32. Obarzanek Fojt M, Curdy C, Loggia N, di Lena F, Grieder K, Bitar M, et al. Tracking immune-related cell responses to drug delivery microparticles in 3D dense collagen matrix. Eur J Pharm Biopharm. 2016;107:180-90 pubmed publisher
    ..b>THP1 cells (human acute monocytic leukaemia cells) differentiated into macrophage-like cells were chosen as cell model ..
  33. Aibara S, Bai X, Stewart M. The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region. J Struct Biol. 2016;195:316-324 pubmed publisher
    ..The TREX-2 complex is based on a Sac3 scaffold to which Thp1, Sem1, Cdc31, and Sus1 bind...
  34. Choi H, Shin J, Kim E, Park S, Bae I, Jo Y, et al. Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model. PLoS ONE. 2016;11:e0168025 pubmed publisher
    ..However, these inhibitory effects disappeared in GLI2 knockdown cells...
  35. Koike Y, Ohta Y, Saitoh W, Yamashita T, Kanomata N, Moriya T, et al. Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells. Breast Cancer. 2017;24:683-693 pubmed publisher
    ..The expression levels of effector molecules in the Hh pathway: glioma-associated oncogene (GLI) 1 and GLI2, were measured...
  36. Wang Y, Su S, Chen S, Tang M, Chen G, Zhao D, et al. C21 steroidal glycosides from Cynanchum taihangense. J Asian Nat Prod Res. 2017;:1-7 pubmed publisher
    ..Their structures were elucidated on the basis of NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. Their cytotoxic activities against three human tumor cell lines (HL-60, THP1, and Caco2) were reported.
  37. Kim J, Hyun J, Wang S, Lee C, Lee J, Moon E, et al. Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling. Sci Rep. 2017;7:3815 pubmed publisher
    ..and phosphorylated glycogen synthase kinase 3 beta (pGSK-3B), an inactive form of GSK-3B degrading glioblastoma 2 (GLI2), followed by the decreased expression of both smoothened and GLI2...
  38. Mitra S, Exline M, Habyarimana F, Gavrilin M, Baker P, Masters S, et al. Microparticulate Caspase-1 Regulates Gasdermin-D and Pulmonary Vascular Endothelial Cell Injury. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
    ..Our current work provides evidence that GSDM-D is released by LPS stimulated THP1 monocytic cells where it is packaged into microparticles along with active caspase-1...
  39. Tang L, Tan Y, Jiang B, Pan Y, Li S, Yang G, et al. The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma. Clin Cancer Res. 2013;19:2014-24 pubmed publisher
    ..In ICC tissues, the Gli1 nuclear immune-intensity was associated with intrahepatic metastasis and the expression of Gli2 was associated with intrahepatic metastasis, venous invasion, and Unio Internationale Contra Cancrum (UICC) pT ..
  40. Morrison C, Schiemann W. Tipping the balance between good and evil: aberrant 14-3-3ζ expression drives oncogenic TGF-β signaling in metastatic breast cancers. Breast Cancer Res. 2015;17:92 pubmed publisher
    ..of tumor-suppressive Smad2/3:p53 complexes, while simultaneously driving the generation of oncogenic Smad2/3:Gli2 complexes...
  41. Dahlin A, Hollegaard M, Wibom C, Andersson U, Hougaard D, Deltour I, et al. CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma. J Neurooncol. 2015;125:75-8 pubmed publisher
    ..on recent publications, we selected 10 genes that were frequently altered in medulloblastoma: CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 (now renamed as KMT2D)...
  42. Schmidt T, Schmid Burgk J, Ebert T, Gaidt M, Hornung V. Designer Nuclease-Mediated Generation of Knockout THP1 Cells. Methods Mol Biol. 2016;1338:261-72 pubmed publisher
    ..a step-by-step workflow for establishing knockout cell clones of the difficult-to-transfect suspension cell line THP1. The here described protocol encompasses electroporation, cell cloning, and a deep sequencing-based genotyping step ..
  43. Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, et al. Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016;409:55-71 pubmed publisher
    ..0, through genetic ablation of Gli2 and Gli3 in the midbrain, results in a phenotype basically identical to the one seen in Ift88 conditional mutants...
  44. Petrovic I, Milivojevic M, Popovic J, Schwirtlich M, Rankovic B, Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS ONE. 2015;10:e0143591 pubmed publisher
    ..We have presented data showing that expression of SOX18 gene is regulated by GLI1 and GLI2 transcription factors, final effectors of Hedgehog signaling, and that modulation of Hedgehog signaling activity in ..
  45. Mezzasoma L, Antognelli C, Talesa V. Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1β release by inhibiting NF-kB, NLRP3 inflammasome and caspase-1 activation in THP-1 cells. Immunol Res. 2016;64:303-12 pubmed publisher
    ..of our study was to evaluate the effect of ANP on IL-1β/NALP3/caspase-1 expression in LPS/ATP-stimulated human THP1 monocytes...
  46. Zhou Y, Huang T, Cheng A, Yu J, Kang W, To K. The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis. Int J Mol Sci. 2016;17: pubmed publisher
    ..facilitate cancer progression via activating a series of progression-inducing genes, such as CTGF, Cyr61, Myc and Gli2. Recent studies have highlighted that TEADs, together with their coactivators, promote or even act as the crucial ..
  47. Ji W, Yu Y, Li Z, Wang G, Li F, Xia W, et al. FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway. Oncotarget. 2016;7:15118-34 pubmed publisher
    ..of FGFR1 and subsequently its downstream ERK signaling enhanced the expression and transcriptional activity of GLI2, which could be blocked by FGFR1 inhibitor/silencing or ERK inhibitor...
  48. Le Tonquèze O, Kollu S, Lee S, Al Salah M, Truesdell S, Vasudevan S. Regulation of monocyte induced cell migration by the RNA binding protein, FXR1. Cell Cycle. 2016;15:1874-82 pubmed publisher
    ..Here we examined the role of FXR1 in THP1 human monocytic leukemic cells that were grown in serum, as well as in early (24 h) serum-starvation conditions ..
  49. Wan H, Cai J, Chen F, Zhu J, Zhong J, Zhong H. SOX12: a novel potential target for acute myeloid leukaemia. Br J Haematol. 2017;176:421-430 pubmed publisher
    ..of SOX12 in acute myeloid leukaemia (AML) using human myeloid leukaemia samples and the acute myeloid cell line THP1. Mononuclear cells were isolated from the bone marrow of AML patients and healthy donors...
  50. Güleç C, Coban N, Özsait Selçuk B, Sirma Ekmekci S, Yildirim O, Erginel Unaltuna N. Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353:6-15 pubmed publisher
    ..chromatin immunoprecipitation (ChIP) followed by tiling array (ChIP-on-chip) for ROR-alpha in monocytic cell line THP1 and endothelial cell line HUVEC...
  51. Li N, Truong S, Nouri M, Moore J, Al Nakouzi N, Lubik A, et al. Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3. Oncogene. 2018;37:2313-2325 pubmed publisher
    ..Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins...
  52. Seres L, Cserepes J, Elkind N, Torocsik D, Nagy L, Sarkadi B, et al. Functional ABCG1 expression induces apoptosis in macrophages and other cell types. Biochim Biophys Acta. 2008;1778:2378-87 pubmed publisher
    ..Induction of ABCG1 expression by LXR activation in Thp1 cells and in human monocyte-derived macrophages was accompanied by a significant increase in the number of ..
  53. França M, Jorge A, Carvalho L, Costalonga E, Vasques G, Leite C, et al. Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly. J Clin Endocrinol Metab. 2010;95:E384-91 pubmed publisher
    b>GLI2 is a transcription factor downstream in Sonic Hedgehog signaling, acting early in ventral forebrain and pituitary development. GLI2 mutations were reported in patients with holoprosencephaly (HPE) and pituitary abnormalities...
  54. Javelaud D, Alexaki V, Dennler S, Mohammad K, Guise T, Mauviel A. TGF-?/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res. 2011;71:5606-10 pubmed publisher
    ..Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged...
  55. Palle K, Mani C, Tripathi K, Athar M. Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance. Cancers (Basel). 2015;7:2330-51 pubmed publisher
    ..through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3...
  56. Uygur A, Young J, Huycke T, Koska M, Briscoe J, Tabin C. Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube. Dev Cell. 2016;37:127-35 pubmed publisher
    ..SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3...
  57. Cao H, Huang Y, Wang L, Wang H, Pang X, Li K, et al. Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages. Oncotarget. 2016;7:65441-65453 pubmed publisher
    ..b>THP1 human leukemic monocytes were induced to differentiate into M2 macrophages by PMA (100 nM) and IL-4 (20 ng/mL)...
  58. Liu X, Pitarresi J, Cuitino M, Kladney R, Woelke S, Sizemore G, et al. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 2016;30:1943-55 pubmed publisher
    ..The mechanism involved activation of AKT and noncanonical activation of the GLI family transcription factor GLI2. GLI2 was phosphorylated at Ser230 in an AKT-dependent fashion and directly regulated Tgfa expression in ..
  59. Zeng C, Wang Y, Lu Q, Chen J, Zhang J, Liu T, et al. SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer. J Exp Clin Cancer Res. 2014;33:75 pubmed publisher
    ..The interaction of SPOP with Gli2 and other related apoptotic proteins was assessed by immunoprecipitation, Western blotting, real-time PCR and dual ..
  60. Jaiswal S, Mishra P. Antimicrobial and antibiofilm activity of curcumin-silver nanoparticles with improved stability and selective toxicity to bacteria over mammalian cells. Med Microbiol Immunol. 2018;207:39-53 pubmed publisher
    ..They also showed anti-inflammatory effect on human macrophages (THP1) by reducing secretion of pro-inflammatory cytokines IL-6 and TNF-? as compared to chemically synthesized AgNPs.
  61. Taylor M, Thorne D, Carr T, Breheny D, Walker P, Proctor C, et al. Assessment of novel tobacco heating product THP1.0. Part 6: A comparative in vitro study using contemporary screening approaches. Regul Toxicol Pharmacol. 2018;93:62-70 pubmed publisher
    ..THPs showed little or no activity in all assays. HCS techniques can extend safety assessments providing information quickly in the early stages of product innovation and development. ..
  62. Hasegawa D, Ochiai Shino H, Onodera S, Nakamura T, Saito A, Onda T, et al. Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE. 2017;12:e0186879 pubmed publisher
    ..The expression of GLI1 and GLI2 substantially decreased in both control and patient-derived iPSCs cultured in OBM, whereas GLI3, SHH, and IHH were ..
  63. McCalla Martin A, Chen X, Linder K, Estrada J, Piedrahita J. Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N. Transgenic Res. 2010;19:869-87 pubmed publisher
    ..was undertaken to characterize the effects of constitutive expression of the hedgehog transcriptional activator, Gli2, in porcine skin...
  64. Bear K, Solomon B. GLI2 mutations typically result in pituitary anomalies with or without postaxial polydactyly. Am J Med Genet A. 2015;167A:2491-2 pubmed publisher
  65. Xu J, Huang G, Zhang Z, Zhao J, Zhang M, Wang Y, et al. Up-Regulation of Glioma-Associated Oncogene Homolog 1 Expression by Serum Starvation Promotes Cell Survival in ER-Positive Breast Cancer Cells. Cell Physiol Biochem. 2015;36:1862-76 pubmed
    ..These findings may provide new insights into the pro-survival mechanisms of Gli1 in breast cancer. ..
  66. Liu Y, Zeng C, Bao N, Zhao J, Hu Y, Li C, et al. Effect of Rab23 on the proliferation and apoptosis in breast cancer. Oncol Rep. 2015;34:1835-44 pubmed publisher
    ..Furthermore, Rab23 decreased Gli1 and Gli2 mRNA levels when compared with the control group...
  67. Goumy C, Gay Bellile M, Salaun G, Kemeny S, Eymard Pierre E, Biard M, et al. A novel 2q14.1q14.3 deletion involving GLI2 and RNU4ATAC genes associated with partial corpus callosum agenesis and severe intrauterine growth retardation. Birth Defects Res A Clin Mol Teratol. 2016;106:793-7 pubmed publisher
    ..The deletion contained 24 coding genes including STEAP3, GLI2, and RNU4ATAC and was inherited from the mild affected mother...
  68. Han W, Jackson D, Matissek S, Misurelli J, Neil M, Sklavanitis B, et al. Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2. J Immunol. 2017;198:4481-4489 pubmed publisher
    ..of cytokines known to play a role in the biology of bone marrow malignancies, we identified CD40L as a novel GLI2 target gene in stromal cells...
  69. Crane A, Brubaker W, Johansson J, Trigunaite A, Ceballos J, Bradt B, et al. Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy. Alzheimers Dement. 2018;14:243-252 pubmed publisher
    ..complement-mediated capture of Aβ antibody immune complexes compared with Aβ alone in both erythrocytes and THP1-derived macrophages...
  70. Saraav I, Singh S, Pandey K, Sharma M, Sharma S. Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a TH1 response. Tuberculosis (Edinb). 2017;106:16-24 pubmed publisher
    ..Our results showed that MymA stimulation of THP1 cells and human monocyte derived macrophages (MDM) lead to upregulation of TLR2 and co-stimulatory molecules CD40, ..
  71. Yang H, Hu L, Liu Z, Qin Y, Li R, Zhang G, et al. Inhibition of Gli1-mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway. Oncol Lett. 2017;14:7970-7976 pubmed publisher
    ..In the present study, it was identified that Gli (glioma-associated oncogene)1 and Gli2 were highly expressed at the protein level in the androgen-independent prostate cancer cell lines PC3 and DU145, ..
  72. Tanimura A, Teshima H, Fujisawa J, Yoshida M. A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins. J Virol. 1993;67:5375-82 pubmed
    ..These results suggest that binding of THP to TRE-2S may be involved in cooperation with one copy of the 21-bp enhancer in responding to Tax trans activation. ..
  73. Pavletich N, Pabo C. Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science. 1993;261:1701-7 pubmed
    ..Analyzing the GLI complex and comparing it with Zif268 offers new perspectives on Zn finger-DNA recognition. ..
  74. Speek M, Njunkova O, Pata I, Valdre E, Kogerman P. A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Mol Biol. 2006;7:13 pubmed
    ..Association of Gli2 with mammalian development and human disease led us to study the structure and expression of the human GLI2...
  75. Kim K, Kim J, Choi Y, Shin Y, Lee H, Seong I, et al. Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium. Pathol Int. 2009;59:279-87 pubmed publisher
    ..The results suggest that the alteration of Hh signaling may be implicated in tumorigenesis of the endometrium. ..
  76. Laner Plamberger S, Wolff F, Kaser Eichberger A, Swierczynski S, Hauser Kronberger C, Frischauf A, et al. Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells. PLoS ONE. 2013;8:e75317 pubmed publisher
    ..The transcription factors GLI1 and GLI2 activate the SOCS1 promoter, which contains five putative GLI binding sites, and GLI2 binding to the promoter was ..
  77. Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D, Schreiber R, et al. Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling. Cell Signal. 2017;30:41-49 pubmed publisher
    ..Similar defects were found in mouse peritoneal Ano10 null macrophages and in human THP1 macrophages with reduced ANO10 expression...
  78. Kozjak Pavlovic V, Herweg J, Rudel T. The role of host cell organelles in the development of Simkania negevensis. Int J Med Microbiol. 2018;308:155-160 pubmed publisher
    ..range of hosts, from unicellular amoeba to a variety of human cells, such as epithelial HeLa and macrophage-like THP1 cells...
  79. LUPU F, Burnett J, Eggenschwiler J. Cell cycle-related kinase regulates mammalian eye development through positive and negative regulation of the Hedgehog pathway. Dev Biol. 2018;434:24-35 pubmed publisher
    ..We simultaneously removed the Hh activator GLI2 in Ccrk mutants (Ccrk-/-;Gli2-/-), which resulted in rescue of optic cup patterning and exacerbation of optic stalk ..
  80. Lara Guzmán O, Gil Izquierdo A, Medina S, Osorio E, Álvarez Quintero R, Zuluaga N, et al. Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages. Redox Biol. 2018;15:1-11 pubmed publisher
    ..Importantly, the main metabolites responsible for the THP1-macrophage response to oxLDL exposure were the oxidative stress markers 5-epi-5-F2t-IsoP, 15-E1t
  81. Kim J, Singh R, Cho Vega J, Drakos E, Davuluri Y, Khokhar F, et al. Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. Mod Pathol. 2009;22:1312-20 pubmed publisher
    ..We assessed 67 cases of diffuse large B-cell lymphoma for expression of SHH (ligand), GLI1, GLI2 and GLI3 (transcriptional effectors of SHH signaling), and the ATP-binding cassette (ABC)G2 (a downstream target of ..
  82. Kerns S, Ostrer H, Stock R, Li W, Moore J, Pearlman A, et al. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2010;78:1292-300 pubmed publisher
    ..This study demonstrates the feasibility of a genome-wide approach to investigate genetic predisposition to radiation injury. ..
  83. Xu L, Liu H, Yan Z, Sun Z, Luo S, Lu Q. Inhibition of the Hedgehog signaling pathway suppresses cell proliferation by regulating the Gli2/miR-124/AURKA axis in human glioma cells. Int J Oncol. 2017;50:1868-1878 pubmed publisher
    ..Here, we report the identification of miR-124 as a novel downstream target of the transcriptional factor Gli2, which is important for proliferation and tumor growth in human glioma cells...
  84. Pinskey J, Franks N, McMellen A, Giger R, Allen B. Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif. J Biol Chem. 2017;292:15192-15204 pubmed publisher
    ..These insights have implications for the development of novel modulators of HH-driven developmental disorders and diseases. ..
  85. Allcock R, Williams J, Price P. The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production. Genes Cells. 2001;6:487-94 pubmed
    ..To determine whether it affects immune responses and hence diseases influenced by MHC haplotypes, U937, THP1 and Jurkat cells were stably transfected with anti-sense DNA corresponding to exons 2-5 of BAT1 using a retroviral ..
  86. Zhang J, Zhang Z, Gao H, Zhang D, Wang W. Down-regulation of SHH/BMP4 signalling in human anorectal malformations. J Int Med Res. 2009;37:1842-50 pubmed
    ..Expression of SHH, GLI family zinc finger 2 (GLI2) and BMP4 mRNA in the posterior wall of the terminal rectum in 40 patients with ARMs (15 high-type and 25 low-type) ..
  87. Vuletic S, Dong W, Wolfbauer G, Tang C, Albers J. PLTP regulates STAT3 and NF?B in differentiated THP1 cells and human monocyte-derived macrophages. Biochim Biophys Acta. 2011;1813:1917-24 pubmed publisher
    ..Incubation of macrophage-like differentiated THP1 cells and human monocyte-derived macrophages with wild-type PLTP in the presence or absence of tumor necrosis ..
  88. An Y, Cai B, Chen J, Lv N, Yao J, Xue X, et al. MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Lett. 2013;329:228-35 pubmed publisher
    ..Our study suggests that targeting MAP3K10 is a potential strategy for the development of alternative therapies for pancreatic cancers. ..
  89. Nagao Kitamoto H, Nagata M, Nagano S, Kitamoto S, Ishidou Y, Yamamoto T, et al. GLI2 is a novel therapeutic target for metastasis of osteosarcoma. Int J Cancer. 2015;136:1276-84 pubmed publisher
    ..We previously demonstrated that knockdown of GLI2 inhibited proliferation of osteosarcoma cells through regulation of the cell cycle...
  90. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, et al. 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015;27:177-92 pubmed publisher
    ..Conversely, 14-3-3ζ stabilizes Gli2 in breast cancer cells, and Gli2 partners with Smads to activate PTHrP and promote TGF-β-induced bone metastasis...
  91. Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed publisher
    ..i>Sufu in CNC leads to a discernible decrease in the repressive Gli3 form and an increase in the full-length Gli2. Finally, we demonstrate that simultaneous deletion of Gli2 and Sufu in CNC completely restores ..
  92. Tocker A, Durocher E, Jacob K, Trieschman K, Talento S, Rechnitzer A, et al. The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. J Immunol. 2017;199:2896-2909 pubmed publisher
    ..Furthermore, knockdown of IQGAP1 in THP1 and HeLa cells causes significantly more IFN-β production in response to cytosolic nucleic acids...