GJC1

Summary

Gene Symbol: GJC1
Description: gap junction protein, gamma 1, 45kDa
Alias: CX45, GJA7, connexin 45, connexin-45, gap junction alpha-7 protein, gap junction gamma-1 protein
Species: human

Top Publications

  1. ncbi Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells
    P J Kausalya
    Institute of Molecular and Cell Biology, Epithelial Cell Biology Laboratory, Singapore
    FEBS Lett 505:92-6. 2001
  2. ncbi Connexin45 interacts with zonula occludens-1 in osteoblastic cells
    J G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Commun Adhes 8:209-12. 2001
  3. pmc Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb
    John E Rash
    Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Neurocytol 34:307-41. 2005
  4. doi Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes
    Diana Marcela Rojas Gomez
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 377:77-85. 2008
  5. ncbi Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice
    Lisa Ceroni
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Eur J Pharmacol 560:193-200. 2007
  6. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
  7. pmc Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations
    E Oviedo-Orta
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Immunology 99:578-90. 2000
  8. pmc Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens
    Sondip K Biswas
    Depatment of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 13:345-59. 2007
  9. pmc Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1
    Xinbo Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Neurosci 28:9769-89. 2008
  10. ncbi Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes
    Aida Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Eur J Pharmacol 503:9-16. 2004

Research Grants

  1. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2010
  2. Function and Expression of Connexins in the pre-Botzinger Complex
    JONATHAN KELTY; Fiscal Year: 2007
  3. Neurotransmitter Mechanisms in the Mammalian Retina
    STEPHEN MASSEY; Fiscal Year: 2007
  4. Neurotransmitter Mechanisms in the Mammalian Retina
    Stephen C Massey; Fiscal Year: 2010
  5. Connexins and electrical synapses in the retina
    David Paul; Fiscal Year: 2007
  6. INTERCELLULAR COMMUNICATION IN THE EYE LENS
    JEAN JIANG; Fiscal Year: 2006
  7. CX43 IN A GENETIC MODEL OF ALTERED MYOCARDIAL CONDUCTION
    Jeffrey Saffitz; Fiscal Year: 2000
  8. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2007
  9. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2009
  10. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2010

Detail Information

Publications136 found, 100 shown here

  1. ncbi Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells
    P J Kausalya
    Institute of Molecular and Cell Biology, Epithelial Cell Biology Laboratory, Singapore
    FEBS Lett 505:92-6. 2001
    ..b>Cx45 interacts with the PDZ domains of ZO-1 and ZO-3, but not ZO-2, via a short C-terminal PDZ binding motif (SVWI)...
  2. ncbi Connexin45 interacts with zonula occludens-1 in osteoblastic cells
    J G Laing
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Commun Adhes 8:209-12. 2001
    Connexin43 (Cx43) and Cx45 are co-expressed in a number of different tissues...
  3. pmc Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb
    John E Rash
    Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Neurocytol 34:307-41. 2005
    ..With mRNA for connexins Cx36, Cx43 and Cx45 detected within ORN somata and Cx36 and Cx43 proteins reported in ORN somata and axons, abundant gap junctions were ..
  4. doi Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes
    Diana Marcela Rojas Gomez
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 377:77-85. 2008
    ..Phenylephrine led to enhanced Cx43 expression with a pEC50 8.00+/-0.06. The other cardiac connexins, Cx40 and Cx45, as well as GAPDH were not affected...
  5. ncbi Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice
    Lisa Ceroni
    Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Eur J Pharmacol 560:193-200. 2007
    ..that the expression levels of SK, IK, as well as vascular connexins, notably 37, 40 and 43 but, potentially, connexin 45, would show correlation with the contribution of EDHF to acetylcholine-mediated vasodilatation as well as, in ..
  6. ncbi mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse
    Subhash C Juneja
    Department of Zoology, The University of Western Ontario, London, Canada
    Indian J Physiol Pharmacol 47:147-56. 2003
    ..The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR...
  7. pmc Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations
    E Oviedo-Orta
    Department of Medical Biochemistry and Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Immunology 99:578-90. 2000
    ..lymphocytes, but Cx40 mRNA expression was confined to tonsil-derived T and B lymphocytes; Cx26, Cx32, Cx37 and Cx45 were not detected by reverse transcription-polymerase chain reaction (RT-PCR)...
  8. pmc Gap junctions contain different amounts of cholesterol which undergo unique sequestering processes during fiber cell differentiation in the embryonic chicken lens
    Sondip K Biswas
    Depatment of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 13:345-59. 2007
    ..The possible mechanism by which cholesterol is removed from gap junction plaques is also investigated...
  9. pmc Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1
    Xinbo Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Neurosci 28:9769-89. 2008
    ..particularly in the inner plexiform layer (IPL), where the two principal neuronal connexin proteins are Cx36 and Cx45. Currently undetermined are coupling relationships between these connexins and whether both are expressed together ..
  10. ncbi Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes
    Aida Salameh
    Medizinische Klinik I, Abteilung Kardiologie, Universitätsklinik Leipzig, Johannisallee 32, 04103 Leipzig, Germany
    Eur J Pharmacol 503:9-16. 2004
    ..connexin40 (Cx40) is expressed in the atria and in the conduction system [together with low levels of connexin45 (Cx45)]...
  11. ncbi Alterations in connexin expression in the bladder of patients with urge symptoms
    Jochen Neuhaus
    Department of Urology, Clinic for Urology, University of Leipzig, Leipzig, Germany
    BJU Int 96:670-6. 2005
    ..of gap junctions between detrusor smooth muscle cells in situ and the distribution of connexin (Cx)40, Cx43 and Cx45 expressions in bladder biopsies from a control group (with bladder tumour) and from patients with urge symptoms, as ..
  12. ncbi Connexin43 null mice reveal that astrocytes express multiple connexins
    R Dermietzel
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Brain Res Brain Res Rev 32:45-56. 2000
    ..Presence of Cx40 and Cx45 in brains and astrocytes cultured from both Cx43 (-/-) mice and wildtype littermates was confirmed by RT-PCR, ..
  13. ncbi Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants
    Laurent Dupays
    Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
    J Mol Cell Cardiol 38:787-98. 2005
    ..due in part to the poor development of the ventricular trabecular network, as well as specific downregulation of Cx45 gene expression...
  14. ncbi Stimulation of lens cell differentiation by gap junction protein connexin 45.6
    Sumin Gu
    Department of Biochemistry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Invest Ophthalmol Vis Sci 44:2103-11. 2003
    ..The present study was undertaken to explore the roles gap junctions play in lens epithelial cell differentiation...
  15. ncbi Opposing effects of nitric oxide on different connexins expressed in the vascular system
    P Kameritsch
    Institute of Physiology, Ludwig Maximilians University, Germany
    Cell Commun Adhes 10:305-9. 2003
    ..In the vascular system, gap junctions can be formed by four different connexins (Cx37, Cx40, Cx43 and Cx45)...
  16. ncbi Multiple members of the connexin gene family participate in preimplantation development of the mouse
    T C Davies
    Department of Zoology, University of Western Ontario, London, Canada
    Dev Genet 18:234-43. 1996
    ..They can be divided into two groups with respect to the timing of mRNA accumulation: Cx31, Cx43, and Cx45 mRNAs accumulate continuously from the two- or four-cell stage, whereas Cx30.3, Cx31...
  17. ncbi Electrical synapses--gap junctions in the brain
    Carola Meier
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Germany
    Results Probl Cell Differ 43:99-128. 2006
    ..We outline the distribution of Cx36 as well as two other neuronal connexins (Cx57 and Cx45) in the nervous system, describing their spatial and temporal expression patterns...
  18. ncbi Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells
    A Butterweck
    Institut für Genetik Abteilung Molekulargenetik, Universitat, Bonn, Germany
    J Membr Biol 141:247-56. 1994
    Antibodies to the gap junction protein connexin45 (Cx45) were obtained by immunizing rabbits with fusion protein consisting of glutathione S-transferase and 138 carboxy-terminal amino acids of mouse Cx45...
  19. pmc Gap junction remodeling associated with cholesterol redistribution during fiber cell maturation in the adult chicken lens
    Sondip K Biswas
    Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 15:1492-508. 2009
    ..We also evaluated the hypothesis that the cleavage of the COOH-terminus of chick Cx50 (formerly Cx45.6) during fiber cell maturation would affect the gap junction remodeling.
  20. doi Identification and expression analysis of connexin-45 and connexin-60 as major connexins in porcine oocytes
    M Nitta
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    J Anim Sci 88:3269-79. 2010
    ..We demonstrate that there is diversity in the connexin genes expressed in mammalian oocytes, and hence in the gap junctions connecting oocytes and cumulus cells...
  21. pmc Permeability of homotypic and heterotypic gap junction channels formed of cardiac connexins mCx30.2, Cx40, Cx43, and Cx45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Heart Circ Physiol 293:H1729-36. 2007
    ..The anionic divalent dye Lucifer yellow (LY) remained permeant in Cx40, Cx43, and Cx45 channels, but transfer through mCx30.2 channels was not detected...
  22. ncbi Modulation of connexin43 alters expression of osteoblastic differentiation markers
    Zhongyong Li
    Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine 500 University Dr, Hershey, 17033, USA
    Am J Physiol Cell Physiol 290:C1248-55. 2006
    ..This suggests that other connexins, such as Cx45, which is expressed to a similar degree in hFOB/Cx43(-) cells and hFOB/pvc cells, contribute to cell-to-cell ..
  23. ncbi Molecular cloning and developmental expression of two chick embryo gap junction proteins
    E C Beyer
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 265:14439-43. 1990
    ..They may provide a mechanism for the formation of communication compartments in the developing myocardium...
  24. doi Differential expression of connexins during histogenesis of the chick retina
    A H Kihara
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    Dev Neurobiol 68:1287-302. 2008
    ..Herein, we analyzed Cx43, Cx45, Cx50, and Cx56 expression during chick retinal histogenesis...
  25. ncbi Expression of connexin 45 in the olfactory system
    Chunbo Zhang
    Department of Cellular and Structural Biology, Neuroscience Program and the Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Brain Res 929:37-47. 2002
    Gap junctions represent an important mode of intercellular communication. Connexin 45 (Cx45) is a member of the connexin family that forms gap junctions between adjacent cells...
  26. pmc Connexins and the kidney
    Fiona Hanner
    Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo St, Los Angeles, CA 90033, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1143-55. 2010
    ..In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle ..
  27. pmc Interactions of connexins with other membrane channels and transporters
    Marc Chanson
    Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland
    Prog Biophys Mol Biol 94:233-44. 2007
    ..Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas ..
  28. ncbi Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells
    Daniele F Condorelli
    Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Catania, Italy
    Eur J Neurosci 18:1807-27. 2003
    ..for neuronal markers, we provide evidence that, among cerebral connexins (Cx26, Cx32, Cx36, Cx37, Cx40, Cx43, Cx45 and Cx47), only Cx45 and Cx36 mRNAs are localized in neuronal cells in both developing and adult rat brain...
  29. ncbi Comparison of connexin expression patterns in the developing mouse heart and human foetal heart
    Steven R Coppen
    Cardiac Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Royal Brompton Hospital, London, UK
    Mol Cell Biochem 242:121-7. 2003
    ..The expression of the three major connexins (Cx43, Cx40 and Cx45) present in cardiac myocytes is known to be developmentally regulated but it is not clear how the patterns in the ..
  30. ncbi Up-regulation of connexin45 in heart failure
    Kathryn A Yamada
    Department of Medicine Cardiovascular Division, Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cardiovasc Electrophysiol 14:1205-12. 2003
    ..Other cardiac connexins may be altered as well. Because connexin45 (Cx45) has been shown to colocalize with Cx43, we determined whether the number, size, or distribution of Cx45 gap ..
  31. ncbi Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens development
    X Sean Yu
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Cell Sci 117:871-80. 2004
    ..sections of the lens tissues showed that MIP(AQP0) consistently localized with gap junction plaques formed by Cx45.6 and Cx56 during the early stages of embryonic chick lens development...
  32. ncbi Expression of connexins 36, 43, and 45 during postnatal development of the mouse retina
    Alexandre Hiroaki Kihara
    Department of Cell and Developmental Biology, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Neurobiol 66:1397-410. 2006
    ..The present study was undertaken to determine the distribution pattern of Cx36, Cx43, and Cx45 by immunofluorescence, as well as their gene expression levels by quantitative PCR during postnatal development of ..
  33. doi Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells
    Margaret Lin Veruki
    University of Bergen, Department of Biomedicine, Jonas Lies vei 91, N 5009 Bergen, Norway
    J Neurophysiol 101:2339-47. 2009
    ..electrical synapses between AII amacrines and on-cone bipolar cells express Cx36 on the amacrine side and Cx36 or Cx45 on the bipolar side...
  34. pmc The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cells
    Sophie Imbeault
    Neural Regeneration Laboratory and Ottawa Institute of Systems Biology, Dept of Biochemistry, Microbiology, and Immunology, University of Ottawa, ON, Canada
    BMC Neurosci 10:13. 2009
    ..It is not known how these two signalling systems interact. Here, we examined the role of ECM components in regulating connexin expression and function in postnatal hippocampal progenitor cells...
  35. doi Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina
    Luis Pérez de Sevilla Müller
    Department of Neurobiology, University of Oldenburg, Oldenburg, Germany
    Vis Neurosci 27:91-101. 2010
    ..In retinal neurons, only connexin 36, connexin 45, connexin 50, and connexin 57 have been described so far...
  36. ncbi Heteromeric mixing of connexins: compatibility of partners and functional consequences
    E C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Cell Commun Adhes 8:199-204. 2001
    ..by Ni-NTA chromatography) to examine heteromeric mixing of Cx43 with other connexins (including Cx26, Cx37, Cx40, Cx45, and Cx56) in transfected cells...
  37. ncbi Connexins and impulse propagation in the mouse heart
    J Jalife
    Department of Pharmacology, SUNY Health Science Center, Syracuse, New York 13210, USA
    J Cardiovasc Electrophysiol 10:1649-63. 1999
    ..Three gap junction proteins, known as connexins, are expressed in the heart: Cx40, Cx43, and Cx45. Each of these proteins forms channels with unique biophysical and electrophysiologic properties, as well as ..
  38. ncbi Contribution of connexins to the function of the vascular wall
    Jacques Antoine Haefliger
    Laboratory of Molecular Biology, Department of Internal Medicine, University Hospital, 19 135S Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Cardiovasc Res 62:345-56. 2004
    ..Connexin 37 (Cx37), Cx40 and Cx43, whereas the underlying smooth muscle cells may express Cx37, Cx40, Cx43 and Cx45. Moreover, myoendothelial gap junctions have also been shown to be involved in the regulation of vascular tone...
  39. ncbi Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins
    Alonso P Moreno
    Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N Capitol Ave Suite 310, Indianapolis, IN 46202, USA
    Cardiovasc Res 62:276-86. 2004
    ..g., cx43, cx45 or cx40...
  40. ncbi The detection of hamster connexins: a comparison of expression profiles with wild-type mouse and the cancer-prone Min mouse
    Véronique Cruciani
    Department of Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Cell Commun Adhes 11:155-71. 2004
    ..using tissues) and 16 connexins from the Chinese hamster cell line V79, were fully (Cx30, Cx31, Cx37, Cx43 and Cx45) or partially sequenced...
  41. ncbi Expression of connexins in embryonic mouse neocortical development
    Cima Cina
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Comp Neurol 504:298-313. 2007
    ..and immunohistochemistry, we found that among the family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was expressed at a very low ..
  42. pmc Is there a role for remodeled connexins in AF? No simple answers
    Heather S Duffy
    Columbia University, New York, New York 10032, USA
    J Mol Cell Cardiol 44:4-13. 2008
    ..Cx40 is the primary, or most abundant, gap junction protein in atria although Cx43 is also abundantly expressed. Cx45 is also expressed in atria, although at low levels...
  43. pmc Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level
    Luke C McSpadden
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Am J Physiol Cell Physiol 297:C339-51. 2009
    ..These results signify connexin isoform and expression level as important contributors to potential electrical interactions between unexcitable cells and myocytes in cardiac tissue...
  44. ncbi Localization of heterotypic gap junctions composed of connexin45 and connexin36 in the rod pathway of the mouse retina
    Karin Dedek
    Department of Neurobiology, University of Oldenburg, D 26111 Oldenburg, Germany
    Eur J Neurosci 24:1675-86. 2006
    ..Two gap junctional proteins, connexin36 (Cx36) and connexin45 (Cx45), appear to play a pivotal role in this pathway because lack of either protein leads to an impairment of visual ..
  45. pmc Upregulation and maintenance of gap junctional communication in lens cells
    Bruce A Boswell
    Department of Biochemistry and Molecular Biology L224, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Eye Res 88:919-27. 2009
    ..We show here that Cx45.6 and Cx56, the chick orthologs of mammalian Cx50 and Cx46, behave similarly in DCDMLs...
  46. ncbi Characterization of zebrafish Cx43.4 connexin and its channels
    T Desplantez
    Physiologisches Institut, Universitat Bern, Switzerland
    Exp Physiol 88:681-90. 2003
    ..4, an orthologue of mammalian and avian Cx45, and the electrophysiological properties of junctional channels formed by this protein...
  47. doi Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture
    Claire Louault
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    Biochim Biophys Acta 1778:2097-104. 2008
    ..show that mRNA and proteins of connexin40 and connexin43 are expressed in cultured cardiac fibroblasts, while Cx45 is not detected...
  48. pmc Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons
    K Dobrenis
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 82:306-15. 2005
    ..Cxs tested, expression of Cx36 mRNA and protein was found in microglial cultures prepared from human and mouse, and Cx45 mRNA was found in mouse microglial cultures...
  49. ncbi Gap junctions and the connexin protein family
    Goran Sohl
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    Cardiovasc Res 62:228-32. 2004
    ..Cx40 were demonstrated to be functionally expressed in mouse and human endothelial cells and Cx40, Cx43 as well as Cx45 in cardiomyocytes of both species...
  50. ncbi Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 95:170-8. 2004
    ..The amount of Cx43, Cx45, and Cx40 in gap junctions was analyzed by immunohistochemistry and confocal microscopy...
  51. ncbi Vascular gap junctions and implications for hypertension
    Nicole M Rummery
    John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Clin Exp Pharmacol Physiol 31:659-67. 2004
    Four connexin (Cx) molecules, namely Cx37, Cx40, Cx43 and Cx45, are expressed in the gap junctions that exist within and between the cellular layers of arteries...
  52. doi Connexin expression patterns in arrhythmogenic right ventricular cardiomyopathy
    Matthias Paul
    Division of Cardiology, Department of Cardiovascular Medicine, University Hospital Munster, Munster, Germany
    Am J Cardiol 111:1488-95. 2013
    ..specimens were taken from 16 patients with definite ARVC (age 48 ± 16 years) and analyzed for Cx40, Cx43, and Cx45 messenger ribonucleic acid expression (relative to glyceraldehyde-3-phosphate-dehydrogenase messenger ribonucleic ..
  53. pmc Interfering amino terminal peptides and functional implications for heteromeric gap junction formation
    Eric C Beyer
    Department of Pediatrics, University of Chicago Chicago, IL, USA
    Front Pharmacol 4:67. 2013
    ..other connexins (Cx), including Cx46 and Cx50 in lens, Cx40 in atrium, Purkinje fibers, and the blood vessel wall, Cx45 in heart, and Cx37 in the ovary...
  54. ncbi Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)
    Donglin Bai
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Pharmacol Exp Ther 319:1452-8. 2006
    ..2-APB also significantly blocked junctional conductance in cell pairs coupled by Cx26, Cx30, Cx36, Cx40, and Cx45 but did not appreciably affect coupling in cell pairs expressing Cx32, Cx43, and Cx46...
  55. ncbi Conductive and kinetic properties of connexin45 hemichannels expressed in transfected HeLa cells
    P Bader
    Department of Physiology, University of Bern, CH 3012, Bern, Switzerland
    J Membr Biol 199:143-54. 2004
    Human HeLa cells transfected with mouse connexin Cx45 were used to examine the conductive and kinetic properties of Cx45 hemichannels. The experiments were carried out on single cells using a voltage-clamp method...
  56. ncbi Expression and developmental regulation of gap junction connexins cx26, cx32, cx43 and cx45 in the rat midbrain-floor
    Doreen Siu Yi Leung
    Neuroanatomy and Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
    Int J Dev Neurosci 20:63-75. 2002
    ..We have investigated expression of cx26, cx32, cx43, and cx45 in the midbrain floor, where nigrostriatal dopaminergic neurons originate and differentiate...
  57. ncbi Cardiac connexins: genes to nexus
    Heather S Duffy
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Adv Cardiol 42:1-17. 2006
    ..Of the connexins, at least 5 (Cx30.2, Cx37, Cx40, Cx43 and Cx45) are prominently expressed in the heart and each shows regional and cell type specific expression...
  58. ncbi Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells
    George C Lin
    Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Cell Sci 117:881-7. 2004
    ..In HeLa/Cx45 transfectants, UTP initiated calcium oscillations similar to those seen in HeLa cells (63% of cells), but HeLa/Cx46 ..
  59. pmc Contribution of intracellular calcium and pH in ischemic uncoupling of cardiac gap junction channels formed of connexins 43, 40, and 45: a critical function of C-terminal domain
    Giriraj Sahu
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India
    PLoS ONE 8:e60506. 2013
    ..5 minutes of OGD decreased the junctional conductance (Gj) of Cx43, Cx40 and Cx45 by 53±3%, 64±1% and 85±2% respectively...
  60. ncbi What do we learn from double Cx40/Cx45-deficient mice about cardiac morphogenetic defects and conduction abnormalities?
    Halina Dobrzynski
    J Mol Cell Cardiol 41:774-7. 2006
  61. pmc Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone
    Konstantin Khodosevich
    Department of Clinical Neurobiology, University Hospital and German Cancer Research Center, DKFZ, Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 109:20107-12. 2012
    ..Thus, overexpression of Cx45 by retroviral injections increased the proliferation of Mash-1-positive transit-amplifying precursor cells in the ..
  62. ncbi Age- and myopathy-dependent changes in connexins of normal and cardiomyopathic Syrian hamster ventricular myocardium
    M Chen
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada
    Can J Physiol Pharmacol 78:669-78. 2000
    ..The major Cx reported in the heart is Cx43, although some Cx40 and Cx45 are also present. There is some evidence for altered Cx content in heart failure...
  63. doi [Gap junctions and bone remodeling]
    Julie Talbot
    INSERM, UMR 957, Universite de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculte de Medecine, CHU de Nantes, Nantes, France
    Biol Aujourdhui 206:125-34. 2012
    ..distributed in different cell types, is the main gap junction protein expressed in human bone cells, although Cx45 and Cx46 have been reported to be expressed as well...
  64. ncbi Roles of connexins in atherosclerosis and ischemia-reperfusion injury
    Sandrine Morel
    Foundation for Medical Research, Cardiology, 2nd Floor, University of Geneva, 64 Avenue de la Roseraie, CH 1211 Geneva, Switzerland
    Curr Pharm Biotechnol 13:17-26. 2012
    ..Four main connexins are expressed in the cardiovascular system: Cx37, Cx40, Cx43 and Cx45. Their expression pattern is not uniform and depends on intrinsic and environmental factors...
  65. pmc Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43
    Philippe Beauchamp
    Department of Physiology, University of Bern, Switzerland
    Circ Res 110:1445-53. 2012
    ..Spatial heterogeneity in connexin (Cx) expression has been implicated in arrhythmogenesis...
  66. doi Endothelin-induced differentiation of Nkx2.5⁺ cardiac progenitor cells into pacemaking cells
    Xi Zhang
    Institute of Biomedical Engineering, The Second Military Medical University, Shanghai, China
    Mol Cell Biochem 366:309-18. 2012
    ..In conclusion, our study support the notion that pacemaking cells originate from Nkx2.5(+) CPCs present in embryonic heart tubes and endothelin-1 might be involved in diversification of cardiomyogenic progenitors toward the cells...
  67. pmc Neurons and β-cells of the pancreas express connexin36, forming gap junction channels that exhibit strong cationic selectivity
    Feliksas F Bukauskas
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Membr Biol 245:243-53. 2012
    ..The P(γ) of Cx36 for AFl-350 is approximately 358, 138, 23 and four times smaller than the P(γ)s of Cx43, Cx40, Cx45, and Cx57, respectively. In contrast, it is 6.5-fold higher than the P(γ) of mCx30...
  68. doi Connexin-based signaling in acute myelogenous leukemia (AML)
    Brynjar Foss
    Department of Health Studies, University of Stavanger, Stavanger, Norway
    Biochim Biophys Acta 1798:1-8. 2010
    ....
  69. pmc Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes
    Xun Ai
    Division of Cardiovascular Disease, Department of Medicine, UAB Center for Cardiovascular Biology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall B140, Birmingham, AL 35294, USA
    Cardiovasc Res 85:751-62. 2010
    ..However, the role of Cx43 downregulation per se in impaired coupling in HF is unclear...
  70. doi Cardiac connexins and impulse propagation
    John A Jansen
    Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, The Netherlands
    J Mol Cell Cardiol 48:76-82. 2010
    ..Cx), of which three main isoforms are found in the conductive and working myocardial cells: Cx40, Cx43, and Cx45. These isoforms are regionally expressed in the heart, which suggests a specific role or function of a specific ..
  71. doi Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides
    Stefan Dhein
    Clinic for Cardiac Surgery, University of Leipzig, Struempellstr 39, 04289, Leipzig, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:221-34. 2010
    ..21 isoforms of connexins are presently known, cardiomyocytes typically are coupled by Cx43 (most abundant), Cx40 or Cx45. Some years ago, antiarrhythmic peptides were discovered and synthesised, which were shown to increase macroscopic ..
  72. ncbi Novel anti-cancer compounds: structure-based discovery of chemical chaperons for p53
    Yumiko Okuda
    Division of Prion Research, Center for Emerging Infectious Diseases, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Oncol Rep 22:739-44. 2009
    ..Simply based on the docking energy, we extracted 70 compounds (GJC1-GJC70) and examined their anti-cancer activity using the MTT assay of the human colon cancer cells, HCT116...
  73. ncbi Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
    B Delorme
    Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
    Circ Res 81:423-37. 1997
    ..Products of several Cx genes have been identified in the mammalian heart (eg, Cx45, Cx43, Cx40, and Cx37), and their expression was shown to be regulated during the development of the myocardium...
  74. pmc Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation
    Armin Just
    Department of Cell and Molecular Physiology, Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Am Soc Nephrol 20:1577-85. 2009
    ..In transgenic mice with Cx40 replaced by Cx45, steady-state autoregulation and TGF were weaker than those in wild-type mice but stronger than those in Cx40-ko ..
  75. doi Connexins participate in the initiation and progression of atherosclerosis
    Sandrine Morel
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
    Semin Immunopathol 31:49-61. 2009
    ..Four connexins are expressed in the vascular wall: Cx37, Cx40, Cx43, and Cx45. Their expression is not uniform in all blood vessels and varies with vascular territory and species...
  76. ncbi Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin
    A Charollais
    Department of Morphology, University of Geneva, Medical School, Centre Medical Universitaire, Switzerland
    Dev Genet 24:13-26. 1999
    ..contain six connexin transcripts, including one that codes for alpha 6 connexin, a protein also referred to as Cx45. This transcript was also identified in isolated pancreatic islets, in FACS-purified suspensions of primary beta ..
  77. ncbi Connexin expression in the retina
    G Sohl
    Institut fur Genetik, Abteilung fur Molekulargenetik, Universitat Bonn, Germany
    Brain Res Brain Res Rev 32:138-45. 2000
    ..Cx36 and Cx45 immunoreactive signals were found in the inner and outer plexiform layer, both of which are known to show ..
  78. doi Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    Janet L Manias
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Cardiovasc Res 80:385-95. 2008
    ....
  79. doi Coexpression of connexin 45 with connexin 43 decreases gap junction size
    Katharina Grikscheit
    Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
    Cell Commun Adhes 15:185-93. 2008
    In the human heart, ventricular myocytes express connexin 43 (Cx43) and traces of Cx45. In congestive heart failure, Cx43 levels decrease, Cx45 levels increase and gap junction size decreases...
  80. pmc Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylation
    Xinye Yin
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas, USA
    Cell Commun Adhes 15:1-11. 2008
    ..We have previously identified an in vivo phosphorylation site, Ser(364), at the COOH terminus of lens connexin (Cx) Cx45.6 and phosphorylation appears to regulate connexin protein turnover...
  81. pmc Connexin36 is required for gap junctional coupling of most ganglion cell subtypes in the mouse retina
    Feng Pan
    Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA
    J Comp Neurol 518:911-27. 2010
    ..Both connexin36 (Cx36) and connexin45 (Cx45) subunits are widely distributed in the inner plexiform layer (IPL) and therefore are likely contribute to gap ..
  82. ncbi Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45
    H L Kanter
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110
    J Mol Cell Cardiol 26:861-8. 1994
    ..and genomic cloning to isolate DNA encoding the gap junction proteins human connexin40 (Cx40) and connexin45 (Cx45)...
  83. doi Expression pattern of connexins in the corneal and limbal epithelium of a primate
    Xiaoyong Yuan
    Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Cornea 28:194-9. 2009
    ..To detect the expression pattern of connexins in epithelial cells of the central cornea and limbus of the macaque...
  84. doi Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors
    Deeqa Ahmed
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, PO Box 4953 Nydalen, NO 0424 Oslo, Norway
    Endocr Relat Cancer 18:C31-4. 2011
    We have previously shown that the gap junction protein γ 1 (GJC1) gene, encoding the connexin-45 protein, is inactivated by promoter hypermethylation in colorectal cancer...
  85. pmc Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    Yuriko Mori
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocr Relat Cancer 18:465-78. 2011
    ..GLP1R), BTG4, homer homolog 2 (HOMER2), zinc finger protein 583 (ZNF583), and gap junction protein, gamma 1 (GJC1)...
  86. pmc pH-dependent modulation of connexin-based gap junctional uncouplers
    Vytenis A Skeberdis
    Lithuanian University of Health Sciences, Institute of Cardiology, 17 Sukilėliųu Avenue, Kaunas 50009, Lithuania
    J Physiol 589:3495-506. 2011
    ..2, Cx36, Cx40, Cx43, Cx45, Cx46, Cx47 and Cx50 by reagents representing several distinct groups of uncouplers, such as long carbon chain ..
  87. doi Regulation of gap junctional communication by astrocytic mitochondrial K(ATP) channels following neurotoxin administration in in vitro and in vivo models
    Kewen Jiang
    Department of Neurology, The Children s Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Neurosignals 19:63-74. 2011
    ..astrocytic GJ coupling in the hippocampus after seizures due to the colabeling of GJ subunit connexin 43 and connexin 45 with glial marker and was increased substantially by the administration of diazoxide...
  88. pmc Mutation screening of the GJA7 (Cx45) gene in a large international series of probands with nonsyndromic hearing impairment
    Xiao Mei Ouyang
    Department of Otolaryngology, University of Miami, Miami, Florida, USA
    Genet Test Mol Biomarkers 15:333-6. 2011
    ..b>Cx45 is another gap junction protein, coded by the GJA7 gene...
  89. doi Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina
    Gerrit Hilgen
    Department of Neurobiology, University of Oldenburg, Germany
    J Comp Neurol 519:433-50. 2011
    In the mouse retina, connexin45 (Cx45) participates in the gap junction between ON cone bipolar cells and AII amacrine cells, which constitutes an essential element of the primary rod pathway...
  90. pmc Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria
    Mia M Thi
    Department of Orthopaedic Surgery, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Am J Physiol Cell Physiol 299:C994-C1006. 2010
    ..Modest to high level of Cx45 expression was detected in MOBs of both genotypes...
  91. ncbi Differential expression of the gap junction proteins connexin45, -43, -40, -31, and -26 in mouse skin
    A Butterweck
    Abt Molekulargenetik der Universität, Bonn Germany
    Eur J Cell Biol 65:152-63. 1994
    ..For this purpose, polyclonal antibodies to Cx31 and Cx45 were raised by immunizing rabbits with fusion proteins of glutathione S-transferase and carboxy-terminal peptides ..
  92. pmc Ageing-related changes of connexins and conduction within the sinoatrial node
    Sandra A Jones
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Physiol 560:429-37. 2004
    ..within the sinoatrial node decreased with age; however, the expression of other cardiac connexins, Cx40 and Cx45, did not differ with age...
  93. doi High-level connexin expression in the human juxtaglomerular apparatus
    Lisa Kurtz
    Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
    Nephron Physiol 116:p1-8. 2010
    ..These gap junctions are formed by cell-specific expression patterns of the vascular connexins Cx37, Cx40, Cx43 and Cx45. In order to obtain a first indication if gap junctions might play a similar important functional role in the ..
  94. pmc Regulation of lens gap junctions by Transforming Growth Factor beta
    Bruce A Boswell
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Biol Cell 21:1686-97. 2010
    ..This reduction in dye coupling is attributable to an inhibition of gap junction assembly. Connexin 45.6, 43, and 56-containing gap junctions are restored, and intercellular dye coupling is increased, if the ..
  95. pmc Homocysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice
    D Rosenberger
    Department of Physiology and Biophysics, School of Medicine, 500 S Preston St, University of Louisville, Louisville, KY 40202, USA
    Nutr Metab Cardiovasc Dis 21:492-8. 2011
    ..that induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 leads to connexin 40, connexin 43, connexin 45 expression changes contributing to decreased cardiac performance and disturbed atrioventricular conduction.
  96. ncbi Expression of multiple gap junction proteins in human fetal and infant hearts
    S C Chen
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Pediatr Res 36:561-6. 1994
    ..Northern blot analysis identified transcripts of connexin40 (Cx40), connexin43 (Cx43), and connexin45 (Cx45) genes in all hearts analyzed...
  97. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    ..In the cardiac-specific CAR-KO (CAR-cKO) mouse, we observed the loss of connexin 45 localization to the cell-cell junctions of the AV node but preservation of connexin 40 and 43 in contracting ..
  98. ncbi Inhibition of connexin 43 expression and function in cultured rat dental pulp cells by antisense oligonucleotide
    Chul Kyun Chung
    Department of Pathology, Tokyo Dental College, 1 2 2, Masago, Mihama ku, Chiba, 261 8502, Japan
    Cell Tissue Res 329:295-300. 2007
    ..Furthermore, AS-treated cells highly expressed CX45, whereas S-treated cells exhibited high expression of CX32...
  99. pmc Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms
    Feliksas F Bukauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:7113-8. 2002
    ..We used cell lines expressing wild-type connexin 45 (Cx45) and connexin 43 fused with enhanced green fluorescent protein (Cx43-EGFP) to examine mechanisms of ..
  100. pmc Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45
    Mindaugas Rackauskas
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biophys J 92:1952-65. 2007
    ..properties of heterotypic gap junction (GJ) channels assembled between cells expressing wild-type Cx40, Cx43, or Cx45 and their fusion forms tagged with color variants of green fluorescent protein...
  101. ncbi Cellular mechanisms of connexin32 mutations associated with CNS manifestations
    Kleopas A Kleopa
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurosci Res 68:522-34. 2002
    ..that these mutants have dominant-negative effects on other connexins expressed by oligodendrocytes, specifically Cx45. We expressed these and other Cx32 mutants in communication-incompetent as well as Cx45-expressing HeLa cells, and ..

Research Grants73

  1. GAP JUNCTIONS AND IONIC CURRENTS IN DEVELOPING HEART
    Jenny J Yang; Fiscal Year: 2010
    ..twenty identified mammalian connexin genes, only four connexins, connexin40 (Cx40), connexin43 (Cx43), connexin45 (Cx45), and connexin 31.9 (Cx31.9), are expressed in the heart...
  2. Function and Expression of Connexins in the pre-Botzinger Complex
    JONATHAN KELTY; Fiscal Year: 2007
    ..This aim will be accomplished using in situ hybridization to detect transcripts for Cx26, Cx32, Cx36, Cx45, Cx47, and Cx59 in PBC neurons in tissue from mice from embryonic day 12 through postnatal day 21...
  3. Neurotransmitter Mechanisms in the Mammalian Retina
    STEPHEN MASSEY; Fiscal Year: 2007
    ..In specific aim 2, we will test the hypothesis that S1 amacrine cells use Cx45. In addition, we will test the hypothesis that Cx36/Cx45 pairs form heterotypic gap junctions between All amacrine ..
  4. Neurotransmitter Mechanisms in the Mammalian Retina
    Stephen C Massey; Fiscal Year: 2010
    ..In specific aim 2, we will test the hypothesis that S1 amacrine cells use Cx45. In addition, we will test the hypothesis that Cx36/Cx45 pairs form heterotypic gap junctions between All amacrine ..
  5. Connexins and electrical synapses in the retina
    David Paul; Fiscal Year: 2007
    ..Using RT-PCR, we have found Cx45 and Cx57 to be prominently expressed in mouse retina...
  6. INTERCELLULAR COMMUNICATION IN THE EYE LENS
    JEAN JIANG; Fiscal Year: 2006
    ..The objective of this application is to understand the mechanistic roles of Cx45.6 in cell differentiation, and in lens growth and development. The central hypothesis is that Cx45...
  7. CX43 IN A GENETIC MODEL OF ALTERED MYOCARDIAL CONDUCTION
    Jeffrey Saffitz; Fiscal Year: 2000
    ..and minus/minus mice does not cause changes in myocardial tissue structure or in the overall tissue content of Cx45 and Cx40 (to be tested in Specific Aim 1); 2) Cx43 functions as the predominant intercellular low resistance ..
  8. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2007
    ..functional gap junctions, formed primarily by the gap junction protein, connexin43 (Cx43), and also by connexin45 (Cx45) [new gene designations: Gja1 and G/a7, respectively]...
  9. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2009
    ..functional gap junctions, formed primarily by the gap junction protein, connexin43 (Cx43), and also by connexin45 (Cx45) [new gene designations: Gja1 and G/a7, respectively]...
  10. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2010
    ..functional gap junctions, formed primarily by the gap junction protein, connexin43 (Cx43), and also by connexin45 (Cx45) [new gene designations: Gja1 and G/a7, respectively]...
  11. INTERCELLULAR COMMUNICATION IN BONE CELL PHYSIOLOGY
    Roberto Civitelli; Fiscal Year: 2000
    ..One of these, connexin43 (Cx43) mediates "chemical" or "dye" coupling between osteoblasts. The other, connexin45 (Cx45), forms functional gap functions of different molecular permeabilities than those formed by Cx43...
  12. The Role of Gap Junctions in Peripheral Odor Coding
    Chunbo Zhang; Fiscal Year: 2004
    ..mature olfactory receptor neurons (ORNs) express gap junction protein subunits connexin 36, connexin 43, and connexin 45. Since ORNs display high input resistance, opening of a single ion channel can elicit action potential ..
  13. Biophysics of CNS Connexins
    VYTAUTAS VERSELIS; Fiscal Year: 2006
    ..studies have established that neurons express Cx36, astrocytes Cx43 and Cx30 and oligodendrocytes Cx32, Cx45 and Cx47. A new GJ gene, Cx30.2 also appears to be expressed in neurons...
  14. INTERCELLULAR COMMUNICATION IN THE LENS
    Lisa Ebihara; Fiscal Year: 2001
    ..Goals will be to see if Cx46 and Cx50 (or Cx56 and Cx45.6, the chicken counterparts) can form heteromeric channels with novel functional properties...
  15. Role of Gap Junctions in Blood Vessel Assembly
    KAREN K contact HIRSCHI; Fiscal Year: 2010
    ..Gap junction channels can be composed of any of ~20 known connexin (Cx) proteins;however, only Cx37, Cx40, Cx43 and Cx45 are expressed in the vasculature...
  16. Role of Gap Junctions in Blood Vessel Assembly
    Karen Hirschi; Fiscal Year: 2009
    ..junction channels can be composed of any of ~20 known connexin (Cx) proteins; however, only Cx37, Cx40, Cx43 and Cx45 are expressed in the vasculature...
  17. EXPRESSION AND REGULATION OF GAP JUNCTION IN BONE CELLS
    THOMAS STEINBERG; Fiscal Year: 2001
    ..pores called gap junctions, and express three different gap junction proteins: connexin43 (Cx43), connexin45 (Cx45) and connexin46 (Cx46)...
  18. Embryonic Stem Cell Derived Biological Pacemaker for the Heart
    Kathrin Banach; Fiscal Year: 2009
    ..We will furthermore use stably transfected ES cell lines that are either deficient for the expression of Cx43 or Cx45 or overexpress Cx45.
  19. Embryonic Stem Cell Derived Biological Pacemaker for the Heart
    Kathrin Banach; Fiscal Year: 2010
    ..We will furthermore use stably transfected ES cell lines that are either deficient for the expression of Cx43 or Cx45 or overexpress Cx45.
  20. Embryonic Stem Cell Derived Biological Pacemaker for the Heart
    Kathrin Banach; Fiscal Year: 2009
    ..We will furthermore use stably transfected ES cell lines that are either deficient for the expression of Cx43 or Cx45 or overexpress Cx45.
  21. Embryonic Stem Cell Derived Biological Pacemaker for the Heart
    Kathrin Banach; Fiscal Year: 2007
    ..We will furthermore use stably transfected ES cell lines that are either deficient for the expression of Cx43 or Cx45 or overexpress Cx45.
  22. Multiphoton imaging of the juxtaglomerular apparatus
    Janos Peti Peterdi; Fiscal Year: 2010
    ..Aim 3 will identify the mechanism and importance of Cx45/ATP-mediated inhibition of renin release using multi-photon imaging...
  23. INTERCELLULAR COMMUNICATION IN THE HEART
    Eric Beyer; Fiscal Year: 1999
    ..extensively studied Cx43 (which is abundant in ventricular myocardium) and the more recently identified Cx40 and Cx45 (which exhibit unique patterns of expression within cardiac tissues and form gap junction channels with distinct ..
  24. CONNEXONS IN CARDIOVASCULAR CELL COMMUNICATION
    Eric Beyer; Fiscal Year: 2007
    ..The major connexin in working myocardium is Cx43, but Cx37, Cx40, and Cx45 are also found in various cardiovascular cells...
  25. Electrophysiological and antiarrhythmic benefit of cell therapy for heart disease
    KENNETH LAURITA; Fiscal Year: 2007
    ..4) Determine if overexpression of connexin protein (Cx40, Cx43, and Cx45) and SDF-1 (stem cell homing factor) can significantly enhance SKMB and MSC cell therapy for SCD associated with Ml...
  26. Electrophysiological and antiarrhythmic benefit of cell therapy for heart disease
    KENNETH LAURITA; Fiscal Year: 2010
    ..4) Determine if overexpression of connexin protein (Cx40, Cx43, and Cx45) and SDF-1 (stem cell homing factor) can significantly enhance SKMB and MSC cell therapy for SCD associated with Ml...
  27. Electrophysiological and antiarrhythmic benefit of cell therapy for heart disease
    KENNETH LAURITA; Fiscal Year: 2009
    ..4) Determine if overexpression of connexin protein (Cx40, Cx43, and Cx45) and SDF-1 (stem cell homing factor) can significantly enhance SKMB and MSC cell therapy for SCD associated with Ml...
  28. STRUCTURAL & ELECTRICAL REMODELING OF CARDIAC CONNEXIN45
    KATHRYN YAMADA; Fiscal Year: 2003
    ..We have obtained exciting new evidence of dramatic, focal increases in Cx45 expression in human hearts from patients with end-stage heart failure who are at high risk for developing malignant ..
  29. MOLECULAR BIOLOGY OF INTERCELLULAR JUNCTIONS
    Daniel Goodenough; Fiscal Year: 2006
    ..3) A systematic study of the retina has revealed that two other connexins, Cx45 and Cx57 are also expressed by retinal neurons...
  30. MOLECULAR BIOLOGY OF INTERCELLULAR JUNCTIONS
    Daniel Goodenough; Fiscal Year: 2003
    ..3) A systematic study of the retina has revealed that two other connexins, Cx45 and Cx57 are also expressed by retinal neurons...
  31. Role of Gap Junctions in Blood Vessel Assembly
    Karen Hirschi; Fiscal Year: 2007
    ..To gain insight into the mechanism(s), we will determine whether other Cx proteins expressed in the vasculature (Cx45, Cx40, Cx37), which exhibit distinct selectivity and regulatory properties, are capable of supporting these ..