GJA4

Summary

Gene Symbol: GJA4
Description: gap junction protein alpha 4
Alias: CX37, gap junction alpha-4 protein, connexin-37, gap junction protein, alpha 4, 37kDa
Species: human
Products:     GJA4

Top Publications

  1. Reed K, Westphale E, Larson D, Wang H, Veenstra R, Beyer E. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest. 1993;91:997-1004 pubmed
    ..reaction amplification and cDNA library screening to clone DNA encoding a human gap junction protein, connexin37 (Cx37). The derived human Cx37 polypeptide contains 333 amino acids, with a predicted molecular mass of 37,238 D...
  2. Zhao S, Liu Y, Li X. [Effect of maternal lipopolysaccharides exposure during pregnancy on vascular structure in neonatal offspring rats]. Zhonghua Xin Xue Guan Bing Za Zhi. 2014;42:498-503 pubmed
    ..transmission electron microscopy, thoracic aortic mRNA and protein expression of connexin (Cx) molecules including Cx37, Cx40, Cx43 and Cx45 in offspring was detected by Real Time PCR and confocal laser-scanning microscope, ..
  3. Meens M, Alonso F, Le Gal L, Kwak B, Haefliger J. Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release. Cell Commun Signal. 2015;13:34 pubmed publisher
    Connexin37 (Cx37) and Cx40 are crucial for endothelial cell-cell communication and homeostasis. Both connexins interact with endothelial nitric oxide synthase (eNOS)...
  4. Acuña Hernández D, Arreola Mendoza L, Santacruz Márquez R, García Zepeda S, Parra Forero L, Olivares Reyes J, et al. Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex. Toxicol Appl Pharmacol. 2018;344:13-22 pubmed publisher
    ..of oocytes undergoing meiotic resumption, decreased GJIC in the COCs, and did not modify GJIC gene (Cx43 and Cx37) and protein (CX43) expression...
  5. Mohanty I, Parija S, Suklabaidya S, Rattan S. Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. Eur J Pharmacol. 2018;827:22-31 pubmed publisher
    ..Quantitative real-time PCR (qPCR) studies determined the change in expression of vascular connexin (Cx), Cx37, Cx40, and Cx43...
  6. Dominguez Rieg J, Burt J, Ruth P, Rieg T. P2Yâ‚‚ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37. Acta Physiol (Oxf). 2015;213:628-41 pubmed publisher
    ..1, expressed in smooth muscle cells) as well as components of the myoendothelial gap junction, connexins 37 and 40 (Cx37, Cx40), all hypothesized to be part of the EDH response...
  7. Htet M, Nally J, Shaw A, Foote B, Martin P, Dempsie Y. Connexin 43 Plays a Role in Pulmonary Vascular Reactivity in Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>Cx43+/−) mice and 37,43Gap27, which is a pharmacological inhibitor of Cx37 and Cx43...
  8. Johnson T, Nerem R. Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress. Endothelium. 2007;14:215-26 pubmed
    ..This study investigates the responses of endothelial connexin 37, connexin 40, and connexin 43 (Cx37, Cx40, and Cx43) to shear stress and substrate...
  9. Donfack N, Alves K, Alves B, Rocha R, Bruno J, Bertolini M, et al. Stroma cell-derived factor 1 and connexins (37 and 43) are preserved after vitrification and in vitro culture of goat ovarian cortex. Theriogenology. 2018;116:83-88 pubmed publisher
    ..Progesterone and estradiol production decreased (P?<?0.05) during in vitro culture. SDF-1? and Cx37 proteins were detected in oocytes and granulosa cells from all the treatments...

More Information

Publications119 found, 100 shown here

  1. Dhein S, Gaertner C, Georgieff C, Salameh A, Schlegel F, Mohr F. Effects of isoprenaline on endothelial connexins and angiogenesis in a human endothelial cell culture system. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:101-8 pubmed publisher
    ..We wanted to investigate whether isoprenaline might induce upregulation of connexins Cx37, Cx40, or Cx43 in human endothelial cells and whether it may promote angiogenesis...
  2. Clark K, Ganesan S, Keating A. Impact of toxicant exposures on ovarian gap junctions. Reprod Toxicol. 2018;81:140-146 pubmed publisher
    ..Not surprisingly, ovarian function is negatively affected in mouse models deficient in Cx genes; loss of Gja4 impairs folliculogenesis while ovaries devoid of Gja1 have reductions in oocyte growth...
  3. Seul K, Kang K, Lee K, Kim S, Beyer E. Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. Biochem Biophys Res Commun. 2004;319:1144-51 pubmed
    ..analysis of their roles in adult endothelial cells, we developed adenoviruses containing the vascular connexins (Cx37, Cx40, and Cx43). We infected cultured human umbilical vein endothelial cells with control or connexin adenoviruses...
  4. Shao L, Chian R, Xu Y, Yan Z, Zhang Y, Gao C, et al. Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes. Reprod Fertil Dev. 2015;: pubmed publisher
    ..Ereg, Tnfaip6 and Efemp1), mitochondrial metabolism (Fdx1 and Aifm2), gap junctions and the cell cycle (Gja1, Gja4, Ccnd2, Ccna2 and Ccnb2) were highlighted as being differentially expressed between the two development stages...
  5. Sampaio da Silva A, Bruno J, de Lima L, Ribeiro de Sá N, Lunardi F, Ferreira A, et al. Connexin 37 and 43 gene and protein expression and developmental competence of isolated ovine secondary follicles cultured in vitro after vitrification of ovarian tissue. Theriogenology. 2016;85:1457-67 pubmed publisher
    ..and organs lead to the loss of membrane proteins that mediate intercellular communications, such as connexins 37 (Cx37) and 43 (Cx43)...
  6. Ganesan S, Nteeba J, Keating A. Impact of obesity on 7,12-dimethylbenz[a]anthracene-induced altered ovarian connexin gap junction proteins in female mice. Toxicol Appl Pharmacol. 2015;282:1-8 pubmed publisher
    The ovarian gap junction proteins alpha 4 (GJA4 or connexin 37; CX37), alpha 1 (GJA1 or connexin 43; CX43) and gamma 1 (GJC1 or connexin 45; CX45) are involved in cell communication and folliculogenesis...
  7. McGinnis L, Kinsey W. Role of focal adhesion kinase in oocyte-follicle communication. Mol Reprod Dev. 2015;82:90-102 pubmed publisher
    ..Follicles containing Ptk2-null oocytes exhibited reduced oocyte diameter, reduced numbers of connexin 37 and 43 foci at the oocyte surface, and impaired dye coupling between oocyte and granulosa cells...
  8. Pan B, Toms D, Shen W, Li J. MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in porcine cumulus cells. Am J Physiol Endocrinol Metab. 2015;308:E525-34 pubmed publisher
    ..of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), zona pellucida 3 (ZP3), and CX37 in the oocytes...
  9. Saito T, Krutovskikh V, Marion M, Ishak K, Bennett W, Yamasaki H. Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene. Int J Cancer. 2000;86:67-70 pubmed
    ..In this study, we analyzed the presence of mutations in the connexin 37 (Cx37) gene in 22 human hepatic angiosarcomas, 6 and 4 of which were associated with exposure to vinyl chloride ..
  10. Yang Y, Chen J, Wu H, Pei X, Chang Q, Ma W, et al. The Increased Expression of Connexin and VEGF in Mouse Ovarian Tissue Vitrification by Follicle Stimulating Hormone. Biomed Res Int. 2015;2015:397264 pubmed publisher
    ..The results suggested that the expressions of Cx37, Cx43, apoptotic molecular caspase-3, and angiogenesis molecular VEGF were confirmed using immunohistochemistry, ..
  11. Pitha J, Hubacek J, Cifkova R, Skodova Z, Stavek P, Lanska V, et al. The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C>T; Pro319Ser) in women. Int Angiol. 2011;30:221-6 pubmed
    ..study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women...
  12. Good M, Ek Vitorín J, Burt J. Structural determinants and proliferative consequences of connexin 37 hemichannel function in insulinoma cells. J Biol Chem. 2014;289:30379-86 pubmed publisher
    ..The C terminus and a channel able to function are necessary, and neither by itself is sufficient, for Cx37 to mediate growth suppression...
  13. Morton S, Chaston D, Howitt L, Heisler J, Nicholson B, Fairweather S, et al. Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice. Hypertension. 2015;65:662-9 pubmed publisher
    ..electric and chemical conductance and acted as a dominant-negative against wildtype Cx40, Cx43, and Cx45, but not Cx37. Endothelial expression of Cx40T152A in Cx40T152ATg mice attenuated ascending vasodilation, without effect on ..
  14. Le Gal L, Alonso F, Mazzolai L, Meda P, Haefliger J. Interplay between connexin40 and nitric oxide signaling during hypertension. Hypertension. 2015;65:910-5 pubmed publisher
    ..Under these conditions, all aortas showed increased levels of Cx40 in endothelial cells and of both Cx37 and Cx45 in smooth muscle cells...
  15. Peng W, Liu Y, Yu Y, Fu Y, Zhao Y, Kuang H, et al. Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1. Eur J Pharmacol. 2015;756:8-14 pubmed publisher
    ..was induced by exposing HUVEC-12 to Ox-LDL (100mg/l) for 24h, which decreased the expression of protective proteins Cx37 and Cx40, but induced atherogenic Cx43 expression, in both mRNA and protein levels, concomitant with the impaired ..
  16. Ciesiółka S, Budna J, Jopek K, Bryja A, Kranc W, Borys S, et al. Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells. Biomed Res Int. 2017;2017:9738640 pubmed publisher
    ..8 and 3.6??M E2. The relative abundance of Cx36, Cx37, Cx40, Cx43, LHR, FSHR, and CYP19A1 mRNA was measured...
  17. Wong C, Christen T, Pfenniger A, James R, Kwak B. Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction?. Atherosclerosis. 2007;191:355-61 pubmed
    ..Patients in the +CAD group had a higher frequency of the Cx37-1019C allele (70.3% versus 65.0%, p=0.004)...
  18. Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer Geindre S, Mach F, et al. Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells. J Mol Cell Cardiol. 2012;53:299-309 pubmed publisher
    ..Connexin37 (Cx37) is highly expressed in endothelial cells (ECs) of healthy arteries, but not in ECs overlying atherosclerotic ..
  19. Kurtz A. Connexins, renin cell displacement and hypertension. Curr Opin Pharmacol. 2015;21:1-6 pubmed publisher
    Vascular gap junctions formed by specific connexins proteins Cx37, 40, 43 and 45 are important for proper vascular function...
  20. Ampey B, Morschauser T, Ramadoss J, Magness R. Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1. Hypertension. 2016;68:982-8 pubmed publisher
    ..Lucifer yellow dye transfer, a response abrogated by Gap27, but not Gap 26, indicating involvement of Cx43, but not Cx37. Confocal microscopy revealed domain partitioning of Cx43 and caveolin-1...
  21. Tyml K. Vitamin C and Microvascular Dysfunction in Systemic Inflammation. Antioxidants (Basel). 2017;6: pubmed publisher
    ..neuronal nitric oxide synthase-derived NO, leading to restored inter-endothelial electrical coupling through connexin 37-containing gap junctions...
  22. Derouette J, Desplantez T, Wong C, Roth I, Kwak B, Weingart R. Functional differences between human Cx37 polymorphic hemichannels. J Mol Cell Cardiol. 2009;46:499-507 pubmed publisher
    A polymorphism in the human Cx37 gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus of the Cx37 protein (P319S), has been proposed as a prognostic marker for atherosclerosis...
  23. Kanady J, Munger S, Witte M, Simon A. Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling. Dev Biol. 2015;405:33-46 pubmed publisher
    ..Cell culture studies have shown that Cx37 is necessary for coordinated activation of the transcription factor NFATc1, which cooperates with Foxc2 (another ..
  24. Motamed M, Sadr Z, Valojerdi M, Moini A, Oryan S, Totonchi M, et al. Tissue Engineered Human Amniotic Membrane Application in Mouse Ovarian Follicular Culture. Ann Biomed Eng. 2017;45:1664-1675 pubmed publisher
    ..Gdf9, Bmp15 and Cx37 were found to have higher expression levels in IAM group...
  25. Munger S, Geng X, Srinivasan R, Witte M, Paul D, Simon A. Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016;412:173-90 pubmed publisher
    ..Three gap junction proteins (Connexins), Cx37, Cx43, and Cx47, are specifically expressed at VVs in a highly polarized fashion...
  26. Niazi Z, Silva G, Ribeiro T, León González A, Kassem M, Mirajkar A, et al. EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress. Hypertens Res. 2017;40:966-975 pubmed publisher
    ..NO synthase and Ang II type 1 receptors were observed in the Ang II group, whereas SKCa and connexin 37 were downregulated...
  27. Hadizadeh M, Mohaddes Ardebili S, Salehi M, Young C, Mokarian F, McClellan J, et al. GJA4/Connexin 37 Mutations Correlate with Secondary Lymphedema Following Surgery in Breast Cancer Patients. Biomedicines. 2018;6: pubmed publisher
    ..We have tested the hypothesis that connexin 37 gene mutations in humans are associated with secondary lymphedema following breast cancer surgery...
  28. Han Y, Xi S, Zhang X, Yan C, Yang Y, Kang J. [Association of C1019T polymorphism in the connexin 37 gene and coronary artery disease in Chinese Han population]. Zhonghua Yi Xue Za Zhi. 2007;87:100-4 pubmed
    To investigate the association between the connexin 37 (CX37) C1019T polymorphism and the susceptibility to coronary artery disease (CAD) in northern Han population of China...
  29. Yuan D, Sun G, Zhang R, Luo C, Ge M, Luo G, et al. Connexin 43 expressed in endothelial cells modulates monocyte‑endothelial adhesion by regulating cell adhesion proteins. Mol Med Rep. 2015;12:7146-52 pubmed publisher
    ..The effects of Cx43 in endothelial cells was independent of Cx37 or Cx40...
  30. Risek B, Guthrie S, Kumar N, Gilula N. Modulation of gap junction transcript and protein expression during pregnancy in the rat. J Cell Biol. 1990;110:269-82 pubmed
    ..Further, it appears that the same gap junction gene in different organs, such as the alpha 1 gene in the uterine myometrium and the heart, can be differentially regulated. ..
  31. Suzuki Y, Taira H, Tsunoda T, Mizushima Sugano J, Sese J, Hata H, et al. Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep. 2001;2:388-93 pubmed
    ..They were distributed over 61.7 bp with a standard deviation of 19.5. Our finding may reflect the dynamic nature of transcriptional initiation events of human genes in vivo. ..
  32. Pfenniger A, Meens M, Pedrigi R, Foglia B, Sutter E, Pelli G, et al. Shear stress-induced atherosclerotic plaque composition in ApoE(-/-) mice is modulated by connexin37. Atherosclerosis. 2015;243:1-10 pubmed publisher
    ..Endothelial connexin37 (Cx37) expression is also regulated by shear stress, which may contribute to localization of atherosclerotic disease...
  33. Campen K, McNatty K, Pitman J. A protective role of cumulus cells after short-term exposure of rat cumulus cell-oocyte complexes to lifestyle or environmental contaminants. Reprod Toxicol. 2017;69:19-33 pubmed publisher
    ..MDMA), nicotine and Δ9-tetrahydrocannabinol (THC) on gap junction genes (Gja1, Gja4) and proteins (GJA1), glucose metabolism genes (Gfpt1, Pfkp) and oocyte growth factor genes (Bmp15, Gdf9), as well ..
  34. Carballo S, Pfenniger A, Carballo D, Garin N, James R, Mach F, et al. Differential Association of Cx37 and Cx40 Genetic Variants in Atrial Fibrillation with and without Underlying Structural Heart Disease. Int J Mol Sci. 2018;19: pubmed publisher
    ..Genetic variants in genes encoding Cx40 and Cx37 affect their expression or function and may contribute to PV arrhythmogenicity...
  35. Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C. Sex differences in environmental and genetic factors for hypertension. Am J Med. 2008;121:811-9 pubmed publisher
    ..of angiotensin-converting enzyme, adrenergic receptor beta(3), aldehyde dehydrogenase 2, calpastatin, connexin 37, hepatic lipase, lipoprotein lipase, peroxisome proliferator-activated receptor gamma, thyrotropin-releasing ..
  36. Hubacek J, Stanek V, Gebauerová M, Pilipčincová A, Poledne R, Aschermann M, et al. Lack of an association between connexin-37, stromelysin-1, plasminogen activator-inhibitor type 1 and lymphotoxin-alpha genes and acute coronary syndrome in Czech Caucasians. Exp Clin Cardiol. 2010;15:e52-6 pubmed
    ..In a Caucasian Czech population sample, genetic variants of connexin-37, stromelysin-1, PAI-1 and lymphotoxin-alpha were not significantly associated with a predisposition toward ACS. ..
  37. Zhao L, Li Y, Wu D, Ma T, Xia S, Liu Z. Cx37 C1019T polymorphism may contribute to the pathogenesis of coronary heart disease. Genet Test Mol Biomarkers. 2014;18:497-504 pubmed publisher
    We conducted a meta-analysis of case-control studies to evaluate whether Cx37 C1019T (rs1764391 C>T) polymorphism may be implicated in the pathogenesis of coronary heart disease (CHD)...
  38. Tang J, Li L, Hu L, Cai Q, Chen L. Association between 1019C/T polymorphism in the connexin 37 gene and dilated cardiomyopathy. Minerva Cardioangiol. 2016;64:114-20 pubmed
    The aim of this paper was to investigate the association between the connexin 37 (CX37) 1019C/T polymorphism and susceptibility to dilated cardiomyopathy (DCM)...
  39. Cadoret V, Frapsauce C, Jarrier P, Maillard V, Bonnet A, Locatelli Y, et al. Molecular evidence that follicle development is accelerated in vitro compared to in vivo. Reproduction. 2017;153:493-508 pubmed publisher
    ..i>INHBB and FST There was a decrease in the expression of oocyte-specific molecular markers GJA4, KIT, ZP3, WEE2 and BMP15 in vitro compared to that in vivo Moreover, a ..
  40. Allagnat F, Dubuis C, Lambelet M, Le Gal L, Alonso F, Corpataux J, et al. Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation. Cardiovasc Res. 2017;113:805-816 pubmed publisher
    ..The aim of this study was to investigate the participation of another Cx, namely Cx37, in the formation of the neointima layer...
  41. Beyer E, Paul D, Goodenough D. Connexin family of gap junction proteins. J Membr Biol. 1990;116:187-94 pubmed
  42. Wang K, Zhang Q, Liu X, Wu L, Zeng M. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. J Mol Neurosci. 2012;48:265-72 pubmed publisher
    ..12?×?10(-5)). In conclusion, we identified four new loci (PKNOX2, MYH13, PHF2, and GPC6) associated with FTD. These findings offer the potential for new insights into the pathogenesis of FTD and schizophrenia. ..
  43. Zhang Y, Xu Y, Kuai Y, Wang S, Xue Q, Shang J. Effect of testosterone on the Connexin37 of sexual mature mouse cumulus oocyte complex. J Ovarian Res. 2016;9:82 pubmed
    ..The objective of the research is to study the effect of testosterone on connexin37 (Cx37) expression so as to provide theoretical basis for adding testosterone in treatment of POR...
  44. Li H, Spagnol G, Pontifex T, Burt J, Sorgen P. Chemical shift assignments of the connexin37 carboxyl terminal domain. Biomol NMR Assign. 2017;11:137-141 pubmed publisher
    Connexin37 (Cx37) is a gap junction protein involved in cell-to-cell communication in the vasculature and other tissues...
  45. Lunardi F, de Aguiar F, Apolloni L, Duarte A, de Sá N, Leal É, et al. Sheep Isolated Secondary Follicles Are Able to Produce Metaphase II Oocytes After Vitrification and Long-Term In Vitro Growth. Biopreserv Biobank. 2017;15:321-331 pubmed publisher
    ..Oocytes from Follicle-Vit in ?-MEM reached metaphase II stage after IVM. Gene expression for CX37, CX43, and Bax was lower in Tissue-Vit groups. For Bcl2, the gene expression was the opposite...
  46. Gemel J, Nelson T, Burt J, Beyer E. Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer. J Membr Biol. 2012;245:231-41 pubmed publisher
    Many tissues express multiple gap junction proteins, or connexins (Cx); for example, Cx43, Cx40, and Cx37 are coexpressed in vascular cells...
  47. Lavrov I, Fox L, Shen J, Han Y, Cheng J. Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus). PLoS ONE. 2016;11:e0152650 pubmed publisher
    ..spinal cord expressed different types of connexins that include connexin 32 (Cx32), connexin 36 (Cx36), connexin 37 (Cx37), and connexin 43 (Cx43)...
  48. Teng Z, Wang C, Wang Y, Huang K, Xiang X, Niu W, et al. Gap junctions are essential for murine primordial follicle assembly immediately before birth. Reproduction. 2016;151:105-15 pubmed publisher
    ..between ovarian cells, because specifically silencing the genes of individual gap junction proteins, such as Gja1, Gja4 or both, has no influence on primordial follicle assembly...
  49. Nakase T, Ishikawa T, Miyata H. Protective effects of connexins in atheromatous plaques in patients of carotid artery stenosis. Neuropathology. 2017;37:97-104 pubmed publisher
    ..The distribution of Cx37 expression was not different between asymptomatic and symptomatic plaques...
  50. Listi F, Candore G, Lio D, Russo M, Colonna Romano G, Caruso M, et al. Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily. Int J Cardiol. 2005;102:269-71 pubmed
    ..The component protein subunits of these channels, called connexin (Cx), belong to a multigene family. Cx37 is involved in growth, regeneration after injury and ageing of the endothelial cells, suggesting its role in ..
  51. Puljung M, Berthoud V, Beyer E, Hanck D. Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol. 2004;124:587-603 pubmed
    ..The model for hCx37 voltage gating as polyvalent block/unblock can be expanded to account for observations in the literature regarding hCx37 gap junction channel behavior. ..
  52. Han Y, Xi S, Zhang X, Yan C, Yang Y, Kang J. Association of connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han Chinese. Cardiology. 2008;110:260-5 pubmed
    Recently, the C1019T polymorphism in the human gene encoding connexin 37 (CX37, encoded by GJA4) has been reported to be associated with coronary artery disease (CAD)/myocardial infarction in different racial groups, but no data are ..
  53. Pfenniger A, Derouette J, Verma V, Lin X, Foglia B, Coombs W, et al. Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells. Arterioscler Thromb Vasc Biol. 2010;30:827-34 pubmed publisher
    The gap junction protein connexin37 (Cx37) plays an important role in cell-cell communication in the vasculature...
  54. Jing Y, Guo S, Zhang X, Sun A, Tao F, Qian H. Association between C1019T polymorphism in the connexin 37 gene and Helicobacter pylori infection in patients with gastric cancer. Asian Pac J Cancer Prev. 2012;13:2363-7 pubmed
    To investigate the association between the connexin 37 C1019T polymorphism and Helicobacter pylori infection in patients with gastric cancer...
  55. Simon A, Goodenough D, Li E, Paul D. Female infertility in mice lacking connexin 37. Nature. 1997;385:525-9 pubmed
    ..Here we show that connexin 37 is present in gap junctions between oocyte and granulosa cells and that connexin 37-deficient mice lack mature (..
  56. Krenacs T, Rosendaal M. Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation. Am J Pathol. 1998;152:993-1004 pubmed
    ..Connexin43 (Cx43) and its mRNA were consistently expressed in human and rodent marrow. Cx37 was found only in the arteriolar endothelium, but neither Cx32 nor -26 were expressed...
  57. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med. 2002;347:1916-23 pubmed
    ..that the risk of myocardial infarction was significantly associated with the C1019T polymorphism in the connexin 37 gene (P<0...
  58. Collings A, Islam M, Juonala M, Rontu R, Kahonen M, Hutri Kähönen N, et al. Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study. Atherosclerosis. 2007;195:379-84 pubmed
    Connexin37 (cx37) C1019T polymorphism has been shown to associate with coronary artery disease in different populations...
  59. Collings A, Raitakari O, Juonala M, Mansikkaniemi K, Kahonen M, Hutri Kähönen N, et al. The influence of smoking and homocysteine on subclinical atherosclerosis is modified by the connexin37 C1019T polymorphism - The Cardiovascular Risk in Young Finns Study. Clin Chem Lab Med. 2008;46:1102-8 pubmed publisher
    A polymorphism C1019T on the connexin37 (Cx37) gene has been found to associate with coronary artery disease...
  60. Kyle J, Minogue P, Thomas B, Domowicz D, Berthoud V, Hanck D, et al. An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci. 2008;121:2744-50 pubmed publisher
    ..To elucidate the role of the N-terminus in connexin37 (CX37), we studied mutant constructs containing partial deletions of its 23 N-terminal amino acids and a construct with a ..
  61. Morel S, Burnier L, Roatti A, Chassot A, Roth I, Sutter E, et al. Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation. Carcinogenesis. 2010;31:1922-31 pubmed publisher
    ..A polymorphism in the human connexin37 (Cx37) gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus (CT) of the Cx37 ..
  62. Vaiyapuri S, Jones C, Sasikumar P, Moraes L, Munger S, Wright J, et al. Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation. 2012;125:2479-91 pubmed publisher
    ..Deletion of the Cx37 gene (Gja4) in transgenic mice reduced platelet aggregation, fibrinogen binding, granule secretion, and clot retraction, ..
  63. Wen D, Du X, Nie S, Dong J, Ma C. Association of Connexin37 C1019T with myocardial infarction and coronary artery disease: a meta-analysis. Exp Gerontol. 2014;58:203-7 pubmed publisher
    Several studies have reported that Connexin37 (Cx37) gene C1019T polymorphism is associated with myocardial infarction (MI) and coronary artery disease (CAD). However, the results remain contradictory...
  64. Guo S, Yang Y, Yang Z, You H, Shi Y, Hu Z, et al. Improving myocardial fractional flow reserve in coronary atherosclerosis via CX37 gene silence: a preclinical validation study in pigs. Interact Cardiovasc Thorac Surg. 2017;: pubmed publisher
    The purpose of this study was to evaluate the effect of CX37 gene silence on myocardial fractional flow reserve (FFR).
  65. Krutovskikh V, Mironov N, Yamasaki H. Human connexin 37 is polymorphic but not mutated in tumours. Carcinogenesis. 1996;17:1761-3 pubmed
    ..In tumours, GJIC is frequently disrupted. We have tested the hypothesis that the connexin 37 (Cx37) gene might be mutated in human tumours from tissues in which the Cx37 gene is known to be expressed...
  66. Boerma M, Forsberg L, van Zeijl L, Morgenstern R, de Faire U, Lemne C, et al. A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development. J Intern Med. 1999;246:211-8 pubmed
    ..In order to strengthen this premise, the aim of the present work was to probe for structural polymorphisms in connexin 37, a gap junctional protein uniquely expressed in endothelial cells, and to assess for potential genotypic ..
  67. Yamada Y. Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke. Circ J. 2006;70:1240-8 pubmed
    Polymorphisms of GJA4 and CYBA and of PAI1 and MMP3 are associated with myocardial infarction (MI) in men and women, respectively...
  68. Tounian A, Aggoun Y, Lacorte J, Dubern B, Clement K, Bonnet D, et al. Influence of polymorphisms in candidate genes on early vascular alterations in obese children. Arch Cardiovasc Dis. 2010;103:10-8 pubmed publisher
    ..Thus, obesity-associated metabolic complications appear to remain the main predictors of arterial alterations in obese children. ..
  69. Van Rijen H, van Kempen M, Analbers L, Rook M, van Ginneken A, Gros D, et al. Gap junctions in human umbilical cord endothelial cells contain multiple connexins. Am J Physiol. 1997;272:C117-30 pubmed
    ..In both arteries and veins, Cx37, Cx40, and Cx43 could be detected in situ and in vitro (passages 2-4)...
  70. Kameritsch P, Khandoga N, Nagel W, Hundhausen C, Lidington D, Pohl U. Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules. J Cell Physiol. 2005;203:233-42 pubmed
    ..Since HUVEC cells variably express three Cx (Cx37, Cx40, and Cx43), this latter aim required the use of transfected HeLa cells (HeLaCx37, HeLaCx43), which do not ..
  71. Wu Z, Lou Y, Jin W, Liu Y, Lu L, Chen Q, et al. The Connexin37 gene C1019T polymorphism and risk of coronary artery disease: a meta-analysis. Arch Med Res. 2014;45:21-30 pubmed publisher
    ..014). Our results indicated that the C1019T polymorphism may be a moderate risk factor for MI and that DM was likely a potential source of between-study heterogeneity. ..
  72. Dyszkiewicz Konwińska M, Bryja A, Jopek K, Budna J, Bukowska D, Antosik P, et al. Expression of connexins in porcine buccal pouch mucosa cells during real-time long-term cell proliferation in vitro: a primary culture approach. J Biol Regul Homeost Agents. 2017;31:567-577 pubmed
    In this study we investigated the expression of connexins Cx36, Cx37, Cx40, Cx43, and Cx45 mRNAs during real-time cellular proliferation in vitro. The oral mucosa cells were isolated from 80 pubertal crossbred Landrace gilts...
  73. Pogoda K, Mannell H, Blodow S, Schneider H, Schubert K, Qiu J, et al. NO Augments Endothelial Reactivity by Reducing Myoendothelial Calcium Signal Spreading: A Novel Role for Cx37 (Connexin 37) and the Protein Tyrosine Phosphatase SHP-2. Arterioscler Thromb Vasc Biol. 2017;37:2280-2290 pubmed publisher
    Because of its strategic position between endothelial and smooth muscle cells in microvessels, Cx37 (Connexin 37) plays an important role in myoendothelial gap junctional intercellular communication...
  74. Bachelot A, Gilleron J, Meduri G, Guberto M, Dulon J, Boucherie S, et al. A common African variant of human connexin 37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect in vitro. Int J Mol Med. 2018;41:640-648 pubmed publisher
    ..Direct genomic sequencing of the coding regions of the GJA4 gene (encoding Cx37) was performed with the aim to identify a deleterious variant associated with POI and absent in ..
  75. van Rijen H, van Kempen M, Postma S, Jongsma H. Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine. 1998;10:258-64 pubmed
    ..Under control conditions, Cx43, Cx40, and Cx37 protein and mRNA were present in HUVEC. After exposure to 0...
  76. Chanson M, Kwak B. Connexin37: a potential modifier gene of inflammatory disease. J Mol Med (Berl). 2007;85:787-95 pubmed
    ..gene association studies have detected a link between a single nucleotide polymorphism in the human connexin37 (Cx37) gene and coronary artery disease or myocardial infarction in various populations...
  77. Kyle J, Berthoud V, Kurutz J, Minogue P, Greenspan M, Hanck D, et al. The N terminus of connexin37 contains an alpha-helix that is required for channel function. J Biol Chem. 2009;284:20418-27 pubmed publisher
    ..Taken together, our data suggest that the alpha-helical structure of the connexin37 N terminus may be dispensable for protein localization, but it is required for channel and hemichannel function. ..
  78. Jacobsen N, Pontifex T, Li H, Solan J, Lampe P, Sorgen P, et al. Regulation of Cx37 channel and growth-suppressive properties by phosphorylation. J Cell Sci. 2017;130:3308-3321 pubmed publisher
    Growth suppression mediated by connexin 37 (Cx37; also known as GJA4) requires interaction between its C-terminus and functional pore-forming domain...
  79. Iwai N, Tago N, Yasui N, Kokubo Y, Inamoto N, Tomoike H, et al. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. J Hypertens. 2004;22:1119-26 pubmed
    ..renal functions (PTGS2, KLK1, NPHS1, NPHS2, SGK, SLC12A1, PTGES), and others related to cardiovascular physiology (GJA4, NOS1, NTRK3, P2RX4, SPP1, ALDH2)...
  80. Katakami N, Sakamoto K, Kaneto H, Matsuhisa M, Shimizu I, Ishibashi F, et al. Association between the connexin37 polymorphism and peripheral arterial disease in subjects with type 2 diabetes. Diabetes Care. 2009;32:e53-4 pubmed publisher
  81. Juo S, Liao Y, Lin H, Chen P, Lin W, Lin R. Lack of association between a functional genetic variant of connexin 37 and ischemic stroke in a Taiwanese population. Thromb Res. 2012;129:e65-9 pubmed publisher
    b>Connexin 37, encoded by the GJA4 gene, protects against atherosclerosis. A recent study reported an association between polymorphism rs1764391 at GJA4 and ischemic stroke in a Chinese population. We aimed to replicate this result...
  82. Richard G, Smith L, Bailey R, Itin P, Hohl D, Epstein E, et al. Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. Nat Genet. 1998;20:366-9 pubmed
    ..6 cM on 1p34-p35, and a candidate gene (GJA4) encoding the gap junction protein alpha-4 (connexin 31, Cx31) was excluded by sequence analysis...
  83. Li X, Simard J. Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001;281:H1890-8 pubmed
    Cells in blood vessel walls express connexin (Cx)43, Cx40, and Cx37. We recently characterized gap junction channels in rat basilar artery smooth muscle cells and found features attributable not only to these three connexins but also to ..
  84. Ebong E, Kim S, DePaola N. Flow regulates intercellular communication in HAEC by assembling functional Cx40 and Cx37 gap junctional channels. Am J Physiol Heart Circ Physiol. 2006;290:H2015-23 pubmed
    ..Vascular endothelial gap junctional channels are formed by the connexin (Cx) proteins Cx37, Cx40, and Cx43...
  85. Yeh H, Chou Y, Liu H, Chang S, Tsai C. Connexin37 gene polymorphism and coronary artery disease in Taiwan. Int J Cardiol. 2001;81:251-5 pubmed
    ..The observation indicates that the polymorphism in the connexin37 gene potentially plays a role in the manifestation of coronary atherosclerosis in Taiwan. ..
  86. Lanfear D, Marsh S, Cresci S, Shannon W, Spertus J, McLeod H. Genotypes associated with myocardial infarction risk are more common in African Americans than in European Americans. J Am Coll Cardiol. 2004;44:165-7 pubmed
    ..of two of the three "risk-associated" genotypes were significantly higher in the AA population: GJA4 C1019T T/T: AA, 20%, EA, 7% (p = 0.053); MMP3 -1171delA A/A: AA, 78%, EA, 24% (p < 0...
  87. Kurtz L, Madsen K, Kurt B, Jensen B, Walter S, Banas B, et al. High-level connexin expression in the human juxtaglomerular apparatus. Nephron Physiol. 2010;116:p1-8 pubmed publisher
    ..These gap junctions are formed by cell-specific expression patterns of the vascular connexins Cx37, Cx40, Cx43 and Cx45...
  88. Angelillo Scherrer A, Fontana P, Burnier L, Roth I, Sugamele R, Brisset A, et al. Connexin 37 limits thrombus propensity by downregulating platelet reactivity. Circulation. 2011;124:930-9 pubmed publisher
    ..In the present study, we show that megakaryocytes and platelets express connexin 37 (Cx37). Deletion of the Cx37 gene in mice shortens bleeding time and increases thrombus propensity...
  89. Petko J, Justice Bitner S, Jin J, Wong V, Kittanakom S, Ferraro T, et al. MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. PLoS ONE. 2013;8:e67608 pubmed publisher
  90. Guruvaiah P, Govatati S, Reddy T, Beeram H, Deenadayal M, Shivaji S, et al. Analysis of Connexin37 gene C1019T polymorphism and PCOS susceptibility in South Indian population: case-control study. Eur J Obstet Gynecol Reprod Biol. 2016;196:17-20 pubmed publisher
    ..The main aim of this study was to investigate the association of Connexin37 (Cx37)/Gap junction alpha 4 (GJA4) gene C1019T single nucleotide polymorphism (SNP) with the susceptibility to polycystic ..
  91. Pacheco Costa R, Kadakia J, Atkinson E, Wallace J, Plotkin L, Reginato R. Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/?-catenin signaling. Bone. 2017;97:105-113 pubmed publisher
    ..Paradoxically; however, Cx37-deficient mice exhibit reduced cortical thickness accompanied by higher bone strength, suggesting a contribution of ..
  92. Wang L, Zhang W, Zhang L, Shi W, Wang Y, Ma K, et al. Association of connexin gene polymorphism with essential hypertension in Kazak and Han Chinese in Xinjiang, China. J Huazhong Univ Sci Technolog Med Sci. 2017;37:197-203 pubmed publisher
    ..This study aimed to investigate the association of the polymorphism of connexin (Cx) genes Cx37, Cx40, and Cx43 with EH in Kazak and Han Chinese in Xinjiang, China...