GIP

Summary

Gene Symbol: GIP
Description: gastric inhibitory polypeptide
Alias: gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide, incretin hormone
Species: human
Products:     GIP

Top Publications

  1. Takeda J, Seino Y, Tanaka K, Fukumoto H, Kayano T, Takahashi H, et al. Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. Proc Natl Acad Sci U S A. 1987;84:7005-8 pubmed
    b>Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum...
  2. Meier J, Nauck M, Kranz D, Holst J, Deacon C, Gaeckler D, et al. Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes. 2004;53:654-62 pubmed
    Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) are important factors in the pathogenesis of type 2 diabetes and have a promising therapeutic potential...
  3. Nitz I, Fisher E, Weikert C, Burwinkel B, Li Y, Mohlig M, et al. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. Mol Nutr Food Res. 2007;51:1046-52 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) stimulates insulin release via interaction with its pancreatic receptor (GIP receptor (GIPR)). GIP also acts as vasoactive protein...
  4. Song D, Getty Kaushik L, Tseng E, Simon J, Corkey B, Wolfe M. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology. 2007;133:1796-805 pubmed
    ..to its role as the primary mediator of the enteroinsular axis, glucose-dependent insulinotropic polypeptide (GIP) may play a critical role in the development of obesity...
  5. Kelly K, BROOKS L, Solomon T, Kashyap S, O Leary V, Kirwan J. The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity. Am J Physiol Endocrinol Metab. 2009;296:E1269-74 pubmed publisher
    ..by decreased beta-cell sensitivity and defects in the potentiation of nutrient-stimulated insulin secretion by GIP. Exercise and diet are known to improve glucose metabolism and the pancreatic insulin response to glucose, and this ..
  6. Ojeda M, Nogales F, Muñoz Del Valle P, Díaz Castro J, Murillo M, Carreras O. Metabolic syndrome and selenium in fetal programming: gender differences. Food Funct. 2016;7:3031-8 pubmed publisher
    ..distribution, glucose, triglycerides, cholesterol, insulin and metabolic hormones [glucagon, leptin, gastric inhibitory polypeptide (GIP), and triiodothyronine (T3)], growth factors, receptor activator of nuclear factor kappa-B ligand ..
  7. Dalle S, Quoyer J, Varin E, Costes S. Roles and regulation of the transcription factor CREB in pancreatic β -cells. Curr Mol Pharmacol. 2011;4:187-95 pubmed
    ..of stimuli including glucose, incretin hormones such as the glucagon-like peptide-1 (GLP-1) or the gastric inhibitory polypeptide (GIP), the pituitary adenylate cyclase-activating polypeptide (PACAP), or growth factors such as the ..
  8. Bohl M, Bjørnshave A, Rasmussen K, Schioldan A, Amer B, Larsen M, et al. Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study. Am J Clin Nutr. 2015;101:870-8 pubmed publisher
    ..origin), free fatty acids (FFAs), insulin, glucose, glucagon, glucagon-like peptide 1 (GLP-1), and gastric inhibitory polypeptide (GIP)...
  9. Kuhre R, Wewer Albrechtsen N, Larsen O, Jepsen S, Balk Møller E, Andersen D, et al. Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Mol Metab. 2018;11:84-95 pubmed publisher
    ..acids robustly stimulate secretion of not only the incretin hormones, glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP-1), but also glucagon and insulin in vivo, to levels comparable to those ..

More Information

Publications138 found, 100 shown here

  1. Găman G, Sarvary E, Gelley F, Doros A, Gorog D, Fehervari I, et al. Analysis of Incretin Hormones After Orthotopic Liver Transplantation. Transplant Proc. 2015;47:2207-9 pubmed publisher
    ..level of incretin hormones, namely glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), were measured with competitive enzyme-linked immunoassay reaction...
  2. Cardoso J, Félix R, Costa C, Palma P, Canario A, Power D. Evolution of the glucagon-like system across fish. Gen Comp Endocrinol. 2018;264:113-130 pubmed publisher
    ..four peptides GCG, glucagon-like peptide 1 and 2 (GLP1 and GLP2) and glucose-dependent insulinotropic peptide (GIP) that activate four specific receptors exist...
  3. Bae E. DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control. Arch Pharm Res. 2016;39:1114-28 pubmed publisher
    ..inhibition of the rapid degradation of incretin hormones, such as glucagon-like peptide (GLP)-1 and gastric inhibitory polypeptide (GIP), thus the plasma concentration of GLP-1 increases, which promotes insulin secretion from the ..
  4. Shimizu T, Sato T, Tsukiyama K, Fujita H, Kato S, Hoizumi M, et al. Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice. Endocrinology. 2017;158:2134-2144 pubmed publisher
    ..b>Gastric inhibitory polypeptide (GIP), which is released from intestinal K-cells after meal ingestion, stimulates insulin secretion ..
  5. Gosmain Y, Cheyssac C, Masson M, Guerardel A, Poisson C, Philippe J. Pax6 is a key component of regulated glucagon secretion. Endocrinology. 2012;153:4204-15 pubmed publisher
    ..secretion in primary α-cell in response to glucose, palmitate, and glucose-dependent insulinotropic peptide (GIP) but not the response to arginine and epinephrine...
  6. Qiu N, Li W, Liu M, Cen X, Shan C, Zhang W, et al. Comparison of Great Curvature Plication with Duodenal-Jejunal Bypass (GCP-DJB) and Sleeve Gastrectomy (SG) on Metabolic Indices and Gut Hormones in Type 2 Diabetes Mellitus Rats. Obes Surg. 2018;28:4014-4021 pubmed publisher
    ..The postprandial secretion curves and area under the curve (AUC) of GLP-1, gastric inhibitory polypeptide (GIP), PYY, and bile acid were also calculated...
  7. Nielsen S, Janum S, Krogh Madsen R, Solomon T, Møller K. The incretin effect in critically ill patients: a case-control study. Crit Care. 2015;19:402 pubmed publisher
    ..the incretin effect, which is mediated by the incretin hormones GLP-1 and glucose-dependent insulinotropic peptide (GIP), is impaired in critically ill patients. The incretin effect (i.e...
  8. Li Z, Fang J, Jiao R, Wei X, Ma Y, Liu X, et al. A novel multi-epitope vaccine based on Dipeptidyl Peptidase 4 prevents streptozotocin-induced diabetes by producing anti-DPP4 antibody and immunomodulatory effect in C57BL/6J mice. Biomed Pharmacother. 2017;89:1467-1475 pubmed publisher
    ..the enzymatic degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). An increasing number of studies have shown the potential benefits of DPP4 inhibitors for type 1 diabetes...
  9. Sinagoga K, McCauley H, Múnera J, Reynolds N, Enriquez J, Watson C, et al. Deriving functional human enteroendocrine cells from pluripotent stem cells. Development. 2018;145: pubmed publisher
    ..EECs secreted several hormones including gastric inhibitory polypeptide (GIP), ghrelin, GLP-1 and oxyntomodulin...
  10. Weng S, Zhang B, Xu C, Feng S, He H. Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats. Obes Surg. 2017;27:657-664 pubmed publisher
    ..oral glucose tolerance (OGT), blood lipids, plasma insulin, glucagon like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) were measured before and after surgery...
  11. You H, Zhang T, Feng W, Gai Y. Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients. BMC Complement Altern Med. 2017;17:459 pubmed publisher
    ..serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05)...
  12. Giezenaar C, Luscombe Marsh N, Hutchison A, Lange K, Hausken T, Jones K, et al. Effect of gender on the acute effects of whey protein ingestion on energy intake, appetite, gastric emptying and gut hormone responses in healthy young adults. Nutr Diabetes. 2018;8:40 pubmed publisher
    ..3D-ultrasonography), blood glucose and plasma insulin, glucagon, ghrelin, cholecystokinin (CCK), gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) concentrations (0-180 min), appetite (visual analogue ..
  13. Breij L, Mulder M, van Vark van der Zee L, Hokken Koelega A. Appetite-regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. Eur J Nutr. 2017;56:1725-1732 pubmed publisher
    ..infants, we measured serum fasting levels of ghrelin, leptin, insulin, glucose-dependent insulinotropic peptide (GIP), pancreatic polypeptide (PP) and peptide YY (PYY) at 3 months and in 41 infants also at 6 months and their ..
  14. Nemati R, Lu J, Tura A, Smith G, Murphy R. Acute Changes in Non-esterified Fatty Acids in Patients with Type 2 Diabetes Receiving Bariatric Surgery. Obes Surg. 2017;27:649-656 pubmed publisher
    ..Glucose, insulin, c-peptide, glucagon like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) were measured, and individual NEFAs were measured using a triple-quadrupole liquid ..
  15. Dobbins R, Greenway F, Chen L, Liu Y, Breed S, Andrews S, et al. Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release. Am J Physiol Gastrointest Liver Physiol. 2015;308:G946-54 pubmed publisher
    ..SGLT1 inhibitor effects on plasma glucose, insulin, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) concentrations were also measured during a standard meal...
  16. Giezenaar C, Trahair L, Luscombe Marsh N, Hausken T, Standfield S, Jones K, et al. Effects of randomized whey-protein loads on energy intake, appetite, gastric emptying, and plasma gut-hormone concentrations in older men and women. Am J Clin Nutr. 2017;106:865-877 pubmed publisher
    ..and blood glucose and plasma gut-hormone concentrations [insulin, glucagon, ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide tyrosine tyrosine (PYY)] were measured, and ad ..
  17. Nikolić D, Al Rasadi K, Al Busaidi N, Al Waili K, Banerjee Y, Al Hashmi K, et al. Incretins, Pregnancy, and Gestational Diabetes. Curr Pharm Biotechnol. 2016;17:597-602 pubmed
    ..Incretins such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), have been suggested to have a role in maternal metabolism and weight as well as fetal growth...
  18. Fernandes G, Santo M, Crespo A, Biancardi G, Mota F, Antonangelo L, et al. Early glycemic control and incretin improvement after gastric bypass: the role of oral and gastrostomy route. Surg Obes Relat Dis. 2019;: pubmed publisher
    ..resistance, pancreatic beta cell function, and the incretin effect of glycogen-like protein 1 and gastric inhibitory polypeptide, but reported data are conflicting...
  19. Galac S, Kars V, Klarenbeek S, Teerds K, Mol J, Kooistra H. Expression of receptors for luteinizing hormone, gastric-inhibitory polypeptide, and vasopressin in normal adrenal glands and cortisol-secreting adrenocortical tumors in dogs. Domest Anim Endocrinol. 2010;39:63-75 pubmed publisher
    ..ATs for the expression of receptors for luteinizing hormone (LH), gastric-inhibitory polypeptide (GIP), and vasopressin (V(1a), V(1b), and V(2)). Normal adrenal glands served as control tissues...
  20. Bligh H, Godsland I, Frost G, Hunter K, Murray P, MacAulay K, et al. Plant-rich mixed meals based on Palaeolithic diet principles have a dramatic impact on incretin, peptide YY and satiety response, but show little effect on glucose and insulin homeostasis: an acute-effects randomised study. Br J Nutr. 2015;113:574-84 pubmed publisher
    ..Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and peptide YY (PYY) concentrations were measured over a period of 180 min...
  21. Svendsen P, Jensen F, Holst J, Haugaard S, Nilas L, Madsbad S. The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women. Scand J Clin Lab Invest. 2012;72:410-9 pubmed publisher
    ..Secretion of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) was measured during an oral glucose tolerance test...
  22. Berlier J, Kharroubi I, Zhang J, Dalla Valle A, Rigutto S, Mathieu M, et al. Glucose-Dependent Insulinotropic Peptide Prevents Serum Deprivation-Induced Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells and Osteoblastic Cells. Stem Cell Rev. 2015;11:841-51 pubmed publisher
    ..The glucose-dependent insulinotropic peptide (GIP) has an anti-apoptotic action in insulin-producing cells...
  23. Ferjan S, Janez A, Jensterle M. DPP4 INHIBITOR SITAGLIPTIN AS A POTENTIAL TREATMENT OPTION IN METFORMIN-INTOLERANT OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME: A PILOT RANDOMIZED STUDY. Endocr Pract. 2018;24:69-77 pubmed publisher
    ..BMI = body mass index; DPP-4 = dipeptidyl peptidase-4; DXA = dual energy X-ray absorptiometry; GIP = glucose-dependent insulinotropic peptide; GLP-1 = glucagon-like peptide-1; HOMA-B = homeostasis model assessment ..
  24. Shah F, Singamsetty S, Guo L, Chuan B, McDonald S, Cooper B, et al. Stimulation of the endogenous incretin glucose-dependent insulinotropic peptide by enteral dextrose improves glucose homeostasis and inflammation in murine endotoxemia. Transl Res. 2018;193:1-12 pubmed publisher
    ..we hypothesized that administration of low-level dextrose via the enteral route would stimulate intestinal incretin hormone production, potentiate insulin secretion in a glucose-dependent manner, and thereby improve glycemic control ..
  25. Wang C, Kang C, Xian Y, Zhang M, Chen X, Pei M, et al. Sensing of L-Arginine by Gut-Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose-Dependent Insulinotropic Peptide Secretion in Pig Model. J Food Sci. 2018;83:2394-2401 pubmed publisher
    ..l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion...
  26. Psichas A, Larraufie P, Goldspink D, Gribble F, Reimann F. Chylomicrons stimulate incretin secretion in mouse and human cells. Diabetologia. 2017;60:2475-2485 pubmed publisher
    ..Chylomicrons stimulate incretin hormone secretion from GLUTag cells as well as from human and murine duodenal cultures...
  27. Kruse M, Keyhani Nejad F, Isken F, Nitz B, Kretschmer A, Reischl E, et al. High-Fat Diet During Mouse Pregnancy and Lactation Targets GIP-Regulated Metabolic Pathways in Adult Male Offspring. Diabetes. 2016;65:574-84 pubmed publisher
    ..Genetic deletion of the gastric inhibitory polypeptide (GIP) receptor (GIPR) prevents high-fat diet (HFD)-induced obesity in mice due to specific changes in ..
  28. Previti E, Salinari S, Bertuzzi A, Capristo E, Bornstein S, Mingrone G. Glycemic control after metabolic surgery: a Granger causality and graph analysis. Am J Physiol Endocrinol Metab. 2017;313:E622-E630 pubmed publisher
    ..Twenty-four-hour plasma glucose, NEFA, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) time courses were obtained and analyzed by Granger causality and graph analyses...
  29. Farey J, Preda T, Fisher O, Levert Mignon A, Stewart R, Karsten E, et al. Effect of Laparoscopic Sleeve Gastrectomy on Fasting Gastrointestinal, Pancreatic, and Adipose-Derived Hormones and on Non-Esterified Fatty Acids. Obes Surg. 2017;27:399-407 pubmed publisher
    ..of C-peptide, insulin, and leptin and significantly lower ghrelin, glucose-dependent insulinotropic peptide (GIP), and resistin compared to non-obese controls (p < 0.05). LSG resulted in a reduction in BMI from 42...
  30. Egerod K, Engelstoft M, Grunddal K, Nøhr M, Secher A, Sakata I, et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology. 2012;153:5782-95 pubmed publisher
    ..cells demonstrated expression of not only CCK but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY), neurotensin, and secretin, but not somatostatin...
  31. Cai J, Li C, Liu Z, Du J, Ye J, Gu Q, et al. Predicting DPP-IV inhibitors with machine learning approaches. J Comput Aided Mol Des. 2017;31:393-402 pubmed publisher
    ..DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema, and hypoglycemia...
  32. Wu T, Little T, Bound M, Borg M, Zhang X, Deacon C, et al. A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes. Diabetes Care. 2016;39:511-7 pubmed publisher
    ..e., glucagon-like peptide-1 [GLP-1] and glucose-dependent insulinotropic polypeptide [GIP])...
  33. Ahlkvist L, Omar B, Pacini G, Ahren B. Evidence for neural contribution to islet effects of DPP-4 inhibition in mice. Eur J Pharmacol. 2016;780:46-52 pubmed publisher
    ..35g/kg) with or without co-administration with GLP-1 or glucose-dependent insulinotropic polypeptide (GIP) (both 3nmol/kg). Furthermore, isolated islets were incubated (1h) in 2.8 and 11...
  34. O Harte F, Ng M, Lynch A, Conlon J, Flatt P. Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice. Mol Cell Endocrinol. 2016;431:133-44 pubmed publisher
    ..and glucagon receptor antagonists, exendin-4(9-39) and (desHis(1)Pro(4)Glu(9))glucagon amide but not by (Pro(3))GIP, indicating lack of GIP receptor involvement...
  35. Li M, Liu Z, Chen Y, Hai Y. Characteristics of iron corrosion scales and water quality variations in drinking water distribution systems of different pipe materials. Water Res. 2016;106:593-603 pubmed publisher
    ..A more than 20-year-old hybrid pipe section assembled of unlined cast iron pipe (UCIP) and galvanized iron pipe (GIP) was selected to investigate physico-chemical characteristics of corrosion scales and their effects on water ..
  36. Aldhoon Hainerová I, Zamrazilová H, Hill M, Hainer V. Insulin sensitivity and its relation to hormones in adolescent boys and girls. Metabolism. 2017;67:90-98 pubmed publisher
    ..Metabolic health defined by HOMA-IR is partly predicted by various hormones. Some of them are gender specific. Free T4/TSH and leptin/adiponectin ratios are related to insulin sensitivity in both genders. ..
  37. Meier J, Nauck M. Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide. Best Pract Res Clin Endocrinol Metab. 2004;18:587-606 pubmed
    The 42 amino acid polypeptide glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) is released from intestinal K-cells in response to nutrient ingestion...
  38. Caruana J, Monte S, Jacobs D, Voytovich C, Ghanim H, Dandona P. Distal small bowel bypass for weight regain after gastric bypass: safety and efficacy threshold occurs at <70% bypass. Surg Obes Relat Dis. 2015;11:1248-55 pubmed publisher
    ..A favorable gut hormone response was observed with 3-hour decrease in glucose-dependent insulinotropic peptide (GIP) by 25% and increase in glucagon-like peptide-1 (GLP-1) by 25%, whereas fasting peptide-YY (PYY) increased by 71% (..
  39. Defilippis E, Givertz M. Treating Diabetes in Patients with Heart Failure: Moving from Risk to Benefit. Curr Heart Fail Rep. 2016;13:111-8 pubmed publisher
    ..Therefore, newer drug classes including dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon-like peptide 1 (GIP-1) agonists, and sodium-glucose cotransporter 2 (SGLT-2) inhibitors are being examined for cardiovascular safety as ..
  40. Könitzer J, Pramanick S, Pan Q, Augustin R, Bandholtz S, HARRIMAN W, et al. Generation of a highly diverse panel of antagonistic chicken monoclonal antibodies against the GIP receptor. MAbs. 2017;9:536-549 pubmed publisher
    ..Antagonizing the glucose-dependent insulinotropic polypeptide (GIP) receptor may open up new therapeutic modalities in the treatment of diabetes and obesity...
  41. Spielman L, Gibson D, Klegeris A. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. Eur J Cell Biol. 2017;96:240-253 pubmed publisher
    The incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are primarily known for their metabolic function in the periphery...
  42. McMillan C, Zapata R, Chelikani P, Snead E, Cosford K. Circulating concentrations of glucagon-like peptide 1, glucose-dependent insulinotropic peptide, peptide YY, and insulin in client-owned lean, overweight, and diabetic cats. Domest Anim Endocrinol. 2016;54:85-94 pubmed publisher
    ..were to measure plasma concentrations of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and peptide YY (PYY) in client-owned newly diagnosed diabetic cats and nondiabetic lean or overweight cats and to ..
  43. Campbell J, Ussher J, Mulvihill E, Kolic J, Baggio L, Cao X, et al. TCF1 links GIPR signaling to the control of beta cell function and survival. Nat Med. 2016;22:84-90 pubmed publisher
    The glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor transduce nutrient-stimulated signals to control beta cell function...
  44. Stefoska Needham A, Beck E, Johnson S, Chu J, Tapsell L. Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects. Mol Nutr Food Res. 2016;60:1118-28 pubmed publisher
    ..In a subset of 20 subjects, plasma glucose, insulin, gastric inhibitory peptide (GIP), glucagon-like peptide-1 (GLP-1), peptide-tyrosine-tyrosine (PYY), and ghrelin were measured...
  45. Iepsen E, Lundgren J, Holst J, Madsbad S, Torekov S. Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. Eur J Endocrinol. 2016;174:775-84 pubmed publisher
    ..glucagon-like peptide 1 (GLP-1), peptide YY3-36 (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity...
  46. Zubiaga L, Abad R, Ruiz Tovar J, Enriquez P, Vílchez J, Calzada M, et al. The Effects of One-Anastomosis Gastric Bypass on Glucose Metabolism in Goto-Kakizaki Rats. Obes Surg. 2016;26:2622-2628 pubmed
    ..hormone levels (glucagon, insulin, glucagon-like peptide-1 [GLP-1], and glucose-dependent insulinotropic peptide [GIP]) were measured. All rats maintained their weight...
  47. Dionne D, Skovsø S, Templeman N, Clee S, Johnson J. Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin. Endocrinology. 2016;157:2724-34 pubmed publisher
    ..Collectively these data demonstrate CR has paradoxical effects on adipose tissue growth in the context of genetically reduced insulin. ..
  48. Suzuki Y, Nakamura N, Miyabe M, Nishikawa T, Miyajima S, Adachi K, et al. Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis. J Diabetes Investig. 2016;7:497-505 pubmed publisher
    The involvement of glucose-dependent insulinotropic polypeptide (GIP) on inflammation was explored in atherosclerosis and adipose tissue...
  49. Nauck M, Kind J, Köthe L, Holst J, Deacon C, Broschag M, et al. Quantification of the Contribution of GLP-1 to Mediating Insulinotropic Effects of DPP-4 Inhibition With Vildagliptin in Healthy Subjects and Patients With Type 2 Diabetes Using Exendin [9-39] as a GLP-1 Receptor Antagonist. Diabetes. 2016;65:2440-7 pubmed publisher
    ..026) and was equivalent to 47 ± 5% of the increments due to vildagliptin. Thus, other mediators appear to contribute significantly to the therapeutic effects of DPP-4 inhibition. ..
  50. Ehses J, Pelech S, Pederson R, McIntosh C. Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J Biol Chem. 2002;277:37088-97 pubmed
    The gastrointestinal hormone, glucose-dependent insulinotropic polypeptide (GIP), is one of the most important regulators of insulin secretion following ingestion of a meal...
  51. Rosso G, Cattaneo A, Zanardini R, Gennarelli M, Maina G, Bocchio Chiavetto L. Glucose metabolism alterations in patients with bipolar disorder. J Affect Disord. 2015;184:293-8 pubmed publisher
    ..was aimed to investigate putative alterations in markers linked to metabolic dysfunctions as C-peptide, Ghrelin, GIP, GLP-1, Glucagon, Insulin, Leptin, PAI-1 (total), Resistin and Visfatin in a sample of BD patients compared to ..
  52. Edwards J, Ackerman C. A Review of Diabetes Mellitus and Exposure to the Environmental Toxicant Cadmium with an Emphasis on Likely Mechanisms of Action. Curr Diabetes Rev. 2016;12:252-8 pubmed
    ..and statistically significant changes in fasting leptin, Glucose-dependent Insulinotropic Polypeptide (GIP) and pancreas polypeptide hormone levels in a subchronic animal model of Cd-induced hyperglycemia...
  53. Hegedűs C, Kovács D, Kiss R, Sári R, Németh J, Szilvássy Z, et al. Effect of long-term olanzapine treatment on meal-induced insulin sensitization and on gastrointestinal peptides in female Sprague-Dawley rats. J Psychopharmacol. 2015;29:1271-9 pubmed publisher
    ..Fasted and post-prandial blood samples were obtained for plasma insulin, leptin, ghrelin, amylin, GLP-1, GIP, PYY and PP determination. Adiposity was characterized by weighing intra-abdominal and inguinal fat pads...
  54. Svendsen B, Pais R, Engelstoft M, Milev N, Richards P, Christiansen C, et al. GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. J Endocrinol. 2016;228:39-48 pubmed publisher
    The incretin hormones glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from intestinal endocrine cells, the so-called L- and K-cells...
  55. Ismail S, Gherardi M, Froese A, Zanoun M, Gigoux V, Clerc P, et al. Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes. Biochem Pharmacol. 2016;120:33-45 pubmed publisher
    ..and on detection of a distinct FRET signal accounting for cAMP production at the surface of endosomes containing GIP, compared to endosomes without GIP...
  56. Ekberg J, Hauge M, Kristensen L, Madsen A, Engelstoft M, Husted A, et al. GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40). Endocrinology. 2016;157:4561-4569 pubmed
    ..3 receptors to be highly expressed and highly enriched in fluorescence-activated cell sorting-purified GLP-1 and GIP cells isolated from transgenic reporter mice...
  57. Rohde U. EndoBarrier gastrointestinal liner. Delineation of underlying mechanisms and clinical effects. Dan Med J. 2016;63: pubmed
    ..RYGB is mediated by an altered gastrointestinal tract anatomy, which in particular favours release of the gut incretin hormone glucagon-like peptide-1 (GLP-1)...
  58. Li Y, Liu W, Li L, Holscher C. D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation. Eur J Pharmacol. 2017;797:162-172 pubmed publisher
    ..Therefore, treatment to improve insulin resistance in T2DM may be useful for PD patients. Glucose dependent insulinotropic polypeptide (GIP) is a member of the incretin hormone family that can promote insulin release and improve ..
  59. Shi L, Zhang Z, Li L, Holscher C. A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. Behav Brain Res. 2017;327:65-74 pubmed publisher
    ..has been identified as a risk factor for AD, the incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP), promising antidiabetic agents for the treatment of type 2 diabetes, have been tested in ..
  60. Yuan Z, Li D, Feng P, Xue G, Ji C, Li G, et al. A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease. Eur J Pharmacol. 2017;812:82-90 pubmed publisher
    ..previously shown that mimetics of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP) mouse model of PD...
  61. Tura A, Bagger J, Ferrannini E, Holst J, Knop F, Vilsbøll T, et al. Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response. Nutr Metab Cardiovasc Dis. 2017;27:1123-1129 pubmed publisher
    ..between the time course of the incretin effect and that of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) during oral glucose tolerance tests (OGTTs), thereby estimating incretin ..
  62. Solomon T, Haus J, Kelly K, Rocco M, Kashyap S, Kirwan J. Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care. 2010;33:1561-6 pubmed publisher
    ..assessed by hyperinsulinemic-euglycemic clamps) and the role of glucose-dependent insulinotropic polypeptide (GIP) were examined. After exercise and diet-induced weight loss (-5.0 +/- 0...
  63. Alssema M, Rijkelijkhuizen J, Holst J, Teerlink T, Scheffer P, Eekhoff E, et al. Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT. Eur J Endocrinol. 2013;169:421-30 pubmed publisher
    ..Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon profiles were analysed as total area under the curve (tAUC) and incremental area under the curve...
  64. López Romero P, Pichardo Ontiveros E, Avila Nava A, Vázquez Manjarrez N, Tovar A, Pedraza Chaverri J, et al. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet. 2014;114:1811-8 pubmed publisher
    ..this study was to evaluate the glycemic index, insulinemic index, glucose-dependent insulinotropic peptide (GIP) index, and the glucagon-like peptide 1 (GLP-1) index, and the effect of nopal on patients with type 2 diabetes ..
  65. Cordomi A, Ismail S, Matsoukas M, Escrieut C, Gherardi M, Pardo L, et al. Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors. Biochem Pharmacol. 2015;96:237-46 pubmed publisher
    ..Mutants on these amino acids were expressed in HEKT 293 cells and characterized in terms of GIP-induced cAMP production...
  66. Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, et al. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia. 2016;59:1533-1541 pubmed publisher
    The action of incretin hormones including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) is potentiated in animal models defective in glucagon action...
  67. Hirano T, Yamashita S, Takahashi M, Hashimoto H, Mori Y, Goto M. Anagliptin, a dipeptidyl peptidase-4 inhibitor, decreases macrophage infiltration and suppresses atherosclerosis in aortic and coronary arteries in cholesterol-fed rabbits. Metabolism. 2016;65:893-903 pubmed publisher
    ..We demonstrated for the first time that a DPP-4 inhibitor can substantially suppress plaque formation in coronary arteries with a marked reduction in macrophage accumulation likely via its anti-inflammatory properties. ..
  68. Coreau A, Narcy J, Lumbroso S. Who Really Wants an Ambitious Large-Scale Restoration of the Seine Estuary? A Strategic Analysis of a Science-Policy Interface Locked in a Stalemate. Environ Manage. 2018;61:834-847 pubmed publisher
    ..has run into difficulties despite the production of a large amount of knowledge by a dedicated organization, GIP Seine Aval...
  69. Gautier J, Fetita S, Sobngwi E, Salaün Martin C. Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes Metab. 2005;31:233-42 pubmed
    ..the incretin effect is mainly caused by two peptide hormones, glucose-dependent insulin releasing polypeptide GIP, and glucagon-like peptide-1 GLP-1...
  70. Shibata E, Aoki K, Tajima K, Taguri M, Terauchi Y. Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes. Expert Opin Pharmacother. 2016;17:889-94 pubmed publisher
    ..The AUCs for plasma glucose, insulin, and total glucose-dependent insulinotropic polypeptide (GIP) were significantly lower for intake schedules B and C, compared with those for intake schedule A...
  71. Pacini G, Ahren B. Glucagon-like peptide-1 and glucose-dependent insulinotropic peptide: effects alone and in combination on insulin secretion and glucose disappearance in mice. Physiol Rep. 2017;5: pubmed publisher
    Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) stimulate insulin secretion. They are both released after meal ingestion, and therefore they might cooperate in their actions...
  72. Christensen M, Knop F, Vilsbøll T, Aaboe K, Holst J, Madsbad S, et al. Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes. Regul Pept. 2010;163:96-101 pubmed publisher
    ..properties of the hormones glucagon-like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) in 8 patients with type 1 diabetes mellitus (T1DM) without paracrine intraislet influence of insulin (C-peptide ..
  73. Rahman S, Senniappan S, Sherif M, Tahir S, Hussain K. Dipeptidyl peptidase-4 expression in pancreatic tissue from patients with congenital hyperinsulinism. Int J Clin Exp Pathol. 2015;8:8199-208 pubmed
    ..Glucagon like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY) and the enzyme; dipeptidyl peptidase-4 (DPP-4) all regulate appetite and glucose homeostasis...
  74. Sparre Ulrich A, Gabe M, Gasbjerg L, Christiansen C, Svendsen B, Hartmann B, et al. GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release. Biochem Pharmacol. 2017;131:78-88 pubmed publisher
    Alternative processing of the precursor protein pro-GIP results in endogenously produced GIP(1-30)NH2, that by DPP-4 cleavage in vivo results in the metabolite GIP(3-30)NH2...
  75. Zhao X, Han Q, Gang X, Lv Y, Liu Y, Sun C, et al. The Role of Gut Hormones in Diet-Induced Weight Change: A Systematic Review. Horm Metab Res. 2017;49:816-825 pubmed publisher
    ..In weight-loss diets, decreased fasting total PYY, GLP-1, CCK, GIP, PP, and amylin along with increased ghrelin levels were observed in most studies...
  76. Choi H, Kramer C, Zinman B, W Connelly P, Retnakaran R. Effect of short-term intensive insulin therapy on the incretin response in early type 2 diabetes. Diabetes Metab. 2019;45:197-200 pubmed publisher
    ..Thus, we sought to evaluate the impact of IIT on GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) secretion in early type 2 diabetes. In this study, 63 patients (age 59±8.3 years, baseline A1c 6.8±0...
  77. Saydam B, Yildiz B. Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome. Curr Pharm Des. 2016;22:5572-5587 pubmed
    ..hormone whereas anorexigenic peptides include glucagon like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY) and cholecystokinin (CCK)...
  78. Skrha J, Busek P, Uhrova J, Hrabal P, Kmochová K, Laclav M, et al. Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss. Pancreatology. 2017;17:89-94 pubmed publisher
    ..In this study we examined plasma concentrations of glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), pancreatic polypeptide (PP), peptide YY (PYY) and neuropeptide Y (NPY), and ..
  79. Regazzo D, Losa M, Albiger N, Terreni M, Vazza G, Ceccato F, et al. The GIP/GIPR axis is functionally linked to GH-secretion increase in a significant proportion of gsp- somatotropinomas. Eur J Endocrinol. 2017;176:543-553 pubmed publisher
    ..This study was aimed at linking the GIP/GIPR pathway to GH secretion in 25 somatotropinomas-derived primary cultures and correlating molecular with ..
  80. Stygar D, Sawczyn T, Skrzep Poloczek B, Owczarek A, Matysiak N, Michalski M, et al. The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats. Obes Surg. 2018;28:748-759 pubmed publisher
    ..Glucose tolerance, insulin tolerance, glucose-stimulated insulin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) secretion, food intake, and body weight were ..
  81. Hosoda Y, Okahara F, Mori T, Deguchi J, Ota N, Osaki N, et al. Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in mice. Food Nutr Res. 2017;61:1361778 pubmed publisher
    ..using an indirect calorimeter, and plasma glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) levels were measured for 120 min after feeding...
  82. Yamane S, Inagaki N. Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis. J Diabetes Investig. 2017;: pubmed publisher
    Gut hormonal substances released in response to nutrients include incretins, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Together, incretins are responsible for 50%-60% of postprandial insulin secretion...
  83. Zhang Y, Du L, Xu Y, Tian L, Tu P, Li M. Characterization of Optimized Functional-Complementary Dual Insulinotorpic Peptide rolGG. Curr Pharm Biotechnol. 2017;: pubmed publisher
    Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) play a similar but complementary role in the regulation of glucose levels in islet ?-cells...
  84. Pederson R, Kieffer T, Pauly R, Kofod H, Kwong J, McIntosh C. The enteroinsular axis in dipeptidyl peptidase IV-negative rats. Metabolism. 1996;45:1335-41 pubmed
    Evidence has accumulated that the incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1(7-36) amide) are degraded and rendered biologically inactive in plasma by the enzyme dipeptidyl peptidase ..
  85. Yamada Y, Seino Y. Physiology of GIP--a lesson from GIP receptor knockout mice. Horm Metab Res. 2004;36:771-4 pubmed
    ..implicated as transmitters of signals from the gut to pancreatic beta-cells was referred to incretin; gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide (GIP) is identified as one of the incretins...
  86. Fujita Y, Chui J, King D, Zhang T, Seufert J, Pownall S, et al. Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells. Am J Physiol Endocrinol Metab. 2008;295:E648-57 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretin hormones that play important roles in maintaining glucose homeostasis and are being actively pursued as novel therapeutic agents for ..
  87. Fujita Y, Wideman R, Asadi A, Yang G, Baker R, Webber T, et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. 2010;138:1966-75 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) and the proglucagon product glucagon-like peptide-1 (GLP-1) are gastrointestinal hormones that are released in response to nutrient intake and promote insulin secretion...
  88. Gjesing A, Ekstrøm C, Eiberg H, Urhammer S, Holst J, Pedersen O, et al. Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits. Diabetologia. 2012;55:1338-45 pubmed publisher
    ..measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among non-diabetic relatives of Danish type 2 diabetic patients...
  89. Calanna S, Urbano F, Piro S, Zagami R, Di Pino A, Spadaro L, et al. Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in metabolic syndrome. Eur J Endocrinol. 2012;166:917-22 pubmed publisher
    ..04); higher GIP levels at 30' (P=0.03), 60' (P=0.01), 90' (P=0.003), and 120' (P=0.004); higher AUC (0-120) for GIP (P=0...
  90. Kuhre R, Gribble F, Hartmann B, Reimann F, Windeløv J, Rehfeld J, et al. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. Am J Physiol Gastrointest Liver Physiol. 2014;306:G622-30 pubmed publisher
    ..hormones with particular focus on glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)...
  91. Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson Laakso E, Asplund O, et al. Genetic determinants of circulating GIP and GLP-1 concentrations. JCI Insight. 2017;2: pubmed publisher
    ..pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis...
  92. Theodorakis M, Carlson O, Muller D, Egan J. Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Diabetes Care. 2004;27:1692-8 pubmed
    ..of gut-derived incretin, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory peptide [GIP]), in compensatory beta-cell hypersecretion during insulin-resistant states and in transition to beta-cell failure ..