GIGYF2

Summary

Gene Symbol: GIGYF2
Description: GRB10 interacting GYF protein 2
Alias: GYF2, PARK11, PERQ2, PERQ3, TNRC15, GRB10-interacting GYF protein 2, PERQ amino acid rich, with GYF domain 3, PERQ amino acid-rich with GYF domain-containing protein 2, Parkinson disease (autosomal recessive, early onset) 11, trinucleotide repeat-containing gene 15 protein
Species: human
Products:     GIGYF2

Top Publications

  1. Yang N, Zhao Y, Liu Z, Zhang R, He Y, Zhou Y, et al. Systematically analyzing rare variants of autosomal-dominant genes for sporadic Parkinson's disease in a Chinese cohort. Neurobiol Aging. 2019;76:215.e1-215.e7 pubmed publisher
    ..had a phenotype closely resembling sporadic PD, we performed a systematic analysis of 7 AD-PD genes (SNCA, LRRK2, GIGYF2, VPS35, EIF4G1, DNAJC13, and CHCHD2) in 1456 Chinese sporadic PD patients and 1568 controls...
  2. Thyme S, Pieper L, Li E, Pandey S, Wang Y, Morris N, et al. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 2019;177:478-491.e20 pubmed publisher
    ..in more than 10 gene-rich regions, including the magnesium transporter cnnm2 and the translational repressor gigyf2, and revealed shared anatomical sites of activity differences, including the pallium, hypothalamus, and tectum...
  3. Lunati A, Lesage S, Brice A. The genetic landscape of Parkinson's disease. Rev Neurol (Paris). 2018;174:628-643 pubmed publisher
    ..since 1997, associated either with autosomal dominant (AD): LRRK2, SNCA, VPS35, GCH1, ATXN2, DNAJC13, TMEM230, GIGYF2, HTRA2, RIC3, EIF4G1, UCHL1, CHCHD2, and GBA; or autosomal recessive (AR) inheritance: PRKN, PINK1, DJ1, ATP13A2, ..
  4. Xie J, Wei Q, Deng H, Li G, Ma L, Zeng H. Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment. PLoS ONE. 2014;9:e108559 pubmed publisher
    Heterozygous Gigyf2⁺/⁻ mice exhibits histopathological evidence of neurodegeneration such as motor dysfunction...
  5. Wang T, Guo H, Xiong B, Stessman H, Wu H, Coe B, et al. De novo genic mutations among a Chinese autism spectrum disorder cohort. Nat Commun. 2016;7:13316 pubmed publisher
    ..1% of patients) followed by CHD8, DSCAM, MECP2, POGZ, WDFY3 and ASH1L. We identify novel DN LGD recurrences (GIGYF2, MYT1L, CUL3, DOCK8 and ZNF292) and DN mutations in previous ASD candidates (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 ..
  6. Gorostidi A, Marti Masso J, Bergareche A, Rodríguez Oroz M, Lopez de Munain A, Ruiz Martinez J. Genetic Mutation Analysis of Parkinson's Disease Patients Using Multigene Next-Generation Sequencing Panels. Mol Diagn Ther. 2016;20:481-91 pubmed publisher
    ..primer panel to amplify and sequence coding exons of 15 PD-associated genes (SNCA, LRRK2, PARK2, PINK1, PARK7, GIGYF2, ATP13A2, UCHL1, PLA2G6, FBXO7, EIF4G1, VPS35, ACMSD, APOE, and GBA)...
  7. Schopp I, Amaya Ramirez C, Debeljak J, Kreibich E, Skribbe M, Wild K, et al. Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes. Nat Commun. 2017;8:15690 pubmed publisher
    ..can probe the proteomes of two distinct functional complexes containing the Ago2 protein and uncover the protein GIGYF2 as a regulator of miRNA-mediated translation repression...
  8. Fu R, Olsen M, Webb K, Bennett E, Lykke Andersen J. Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA. 2016;22:373-82 pubmed publisher
    ..Here we identify the cap-binding translation repression 4EHP-GYF2 complex as a cofactor of TTP...
  9. Kim M, Semple I, Kim B, Kiers A, Nam S, Park H, et al. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy. 2015;11:1358-72 pubmed publisher
    ..in Drosophila, we identified CG11148, whose product is orthologous to GIGYF1 (GRB10-interacting GYF protein 1) and GIGYF2 in mammals, as a new autophagy regulator; we hereafter refer to this gene as Gyf...

More Information

Publications51

  1. Amaya Ramirez C, Hubbe P, Mandel N, Béthune J. 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Nucleic Acids Res. 2018;46:5792-5808 pubmed publisher
    Initially identified as a factor involved in tyrosine kinase receptor signaling, Grb10-interacting GYF protein 2 (GIGYF2) has later been shown to interact with the 5' cap-binding protein 4EHP as part of a translation repression complex, ..
  2. Webb T, Erdmann J, Stirrups K, Stitziel N, Masca N, Jansen H, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. J Am Coll Cardiol. 2017;69:823-836 pubmed publisher
    ..We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP)...
  3. Cardona F, Perez Tur J. Other Proteins Involved in Parkinson's Disease and Related Disorders. Curr Protein Pept Sci. 2017;18:765-778 pubmed publisher
    ..or functional data (as for PLA2G6 or DNAJC6), or even their doubtful association with the disease (as for GIGYF2, SYNJ1 and SPR)...
  4. Guella I, Pistocchi A, Asselta R, Rimoldi V, Ghilardi A, Sironi F, et al. Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene. Neurobiol Aging. 2011;32:1994-2005 pubmed publisher
    The Grb10-Interacting GYF Protein-2 (GIGYF2) gene has been proposed as the Parkinson-disease (PD) gene underlying the PARK11 locus...
  5. Pankratz N, Nichols W, Uniacke S, Halter C, Rudolph A, Shults C, et al. Significant linkage of Parkinson disease to chromosome 2q36-37. Am J Hum Genet. 2003;72:1053-7 pubmed
    ..1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility. ..
  6. Wang L, Guo J, Zhang W, Xu Q, Zuo X, Shi C, et al. Follow-up study of variants of the GIGYF2 gene in Chinese patients with Parkinson’s disease. J Clin Neurosci. 2011;18:1699-701 pubmed publisher
    The Grb10-interacting GYF protein-2 gene (GIGYF2) is a PARK11 gene that reportedly has a causal role in familial Parkinson’s disease (PD) among populations from Italy and France...
  7. Tsukuda S, Kusayanagi T, Umeda E, Watanabe C, Tosaki Y, Kamisuki S, et al. Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2. Bioorg Med Chem. 2013;21:311-20 pubmed publisher
    ..In this study, a T7 phage display screen and subsequent binding analyses have identified Grb10 interacting GYF protein 2 (GIGYF2) as a RID-B-binding protein...
  8. Zhang Y, Sun Q, Yu R, Guo J, Tang B, Yan X. The contribution of GIGYF2 to Parkinson's disease: a meta-analysis. Neurol Sci. 2015;36:2073-9 pubmed publisher
    The contribution of the gene of GIGYF2, Grb10-Interacting GYF Protein 2, to Parkinson's disease (PD) is still ambiguous...
  9. Kryszke M, Adjeriou B, Liang F, Chen H, Dautry F. Post-transcriptional gene silencing activity of human GIGYF2. Biochem Biophys Res Commun. 2016;475:289-94 pubmed publisher
    ..As the GYF domain of human GIGYF2 was shown to bind AGO2 in pulldown experiments, we wondered whether GIGYF2 could be a novel protein component of ..
  10. Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, et al. GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism Relat Disord. 2009;15:703-5 pubmed publisher
    Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations...
  11. Margolis R, Abraham M, Gatchell S, Li S, Kidwai A, Breschel T, et al. cDNAs with long CAG trinucleotide repeats from human brain. Hum Genet. 1997;100:114-22 pubmed
    ..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment. ..
  12. Bras J, Simon Sanchez J, Federoff M, Morgadinho A, Januario C, Ribeiro M, et al. Lack of replication of association between GIGYF2 variants and Parkinson disease. Hum Mol Genet. 2009;18:341-6 pubmed publisher
    Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans...
  13. Bonetti M, Ferraris A, Petracca M, Bentivoglio A, Dallapiccola B, Valente E. GIGYF2 variants are not associated with Parkinson's disease in Italy. Mov Disord. 2009;24:1867-8; author reply 1868-9 pubmed publisher
  14. Tomecki R, Kristiansen M, Lykke Andersen S, Chlebowski A, Larsen K, Szczesny R, et al. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. EMBO J. 2010;29:2342-57 pubmed publisher
    ..Both hDIS3 and hDIS3L are active exonucleases; however, only hDIS3 has retained endonucleolytic activity. Our data suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. ..
  15. Zimprich A, Schulte C, Reinthaler E, Haubenberger D, Balzar J, Lichtner P, et al. PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease. Parkinsonism Relat Disord. 2009;15:532-4 pubmed publisher
    The GIGYF2 (Grb10-Interacting GYF Protein-2) gene has recently been proposed to be the responsible gene for the PARK11 locus...
  16. Zhang Y, Zheng L, Zhang T, Wang Y, Xiao Q, Fei Q, et al. GIGYF2 Asn56Ser mutation is rare in Chinese Parkinson's disease patients. Neurosci Lett. 2009;463:172-5 pubmed publisher
    Grb10-Interacting GYF Protein-2 gene (GIGYF2) has been suggested as a candidate gene for PARK11 locus since seven different GIGYF2 missense mutations were identified in familial Parkinson's disease (PD) patients of European descent...
  17. Meeus B, Nuytemans K, Crosiers D, Engelborghs S, Pals P, Pickut B, et al. GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population. Neurobiol Aging. 2011;32:308-12 pubmed publisher
    Missense mutations were identified in the Grb10-Interacting GYF Protein-2 gene (GIGYF2), located in the chromosomal region 2q36-q37, in familial Parkinson disease (PD) patients of European descent...
  18. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland K, Smith R. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564-73 pubmed
    ..of Grb10 was shown to interact with two novel proteins, designated GIGYF1 (Grb10 interacting GYF protein 1) and GIGYF2. Mutation analysis indicates that a 17-amino acid sequence in GIGYF1 and GIGYF2, homologous to the GYF domain ..
  19. Lautier C, Goldwurm S, Durr A, Giovannone B, Tsiaras W, Pezzoli G, et al. Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease. Am J Hum Genet. 2008;82:822-33 pubmed publisher
    The genetic basis for association of the PARK11 region of chromosome 2 with familial Parkinson disease (PD) is unknown...
  20. Burl R, Clough S, Sendler E, Estill M, Krawetz S. Sperm RNA elements as markers of health. Syst Biol Reprod Med. 2017;:1-14 pubmed publisher
    ..The transcripts ACE, GIGYF2, and ODF2 had many negative correlations and form the majority of correlations, suggesting an important function ..
  21. Ruiz Martinez J, Krebs C, Makarov V, Gorostidi A, Martí Massó J, Paisán Ruiz C. GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment. J Hum Genet. 2015;60:637-40 pubmed publisher
    ..A novel genetic variant (p.Arg610Gly) in the GIGYF2 gene, previously known to be associated with PD, was identified as potential disease-causing mutation...
  22. Lesage S, Condroyer C, Lohman E, Troiano A, Tison F, Viallet F, et al. Follow-up study of the GIGYF2 gene in French families with Parkinson's disease. Neurobiol Aging. 2010;31:1069-71; discussion 1072-4 pubmed publisher
    ..Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an ..
  23. Cao L, Zhang T, Zheng L, Wang Y, Wang G, Zhang J, et al. The GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese population. Parkinsonism Relat Disord. 2010;16:294-7 pubmed publisher
    In order to determine the prevalence of GIGYF2 (Grb10-Interacting GYF Protein 2) variants in the Chinese population and to better understand the association between GIGYF2 and Parkinson's disease (PD), we conducted the genetic screening ..
  24. Sutherland G, Siebert G, Newman J, Silburn P, Boyle R, O Sullivan J, et al. Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease. Mov Disord. 2009;24:449-52 pubmed publisher
    ..Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1)...
  25. Guo Y, Jankovic J, Zhu S, Le W, Song Z, Xie W, et al. GIGYF2 Asn56Ser and Asn457Thr mutations in Parkinson disease patients. Neurosci Lett. 2009;454:209-11 pubmed publisher
    ..Recently, Asn56Ser or Asn457Thr mutations in the Grb10-Interacting GYF Protein-2 gene (GIGYF2) were found to occur in about 2.4% familial PD Italian and French patients...
  26. Li L, Funayama M, Tomiyama H, Li Y, Yoshino H, Sasaki R, et al. No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients. Neurosci Lett. 2010;479:245-8 pubmed
    Grb10-Interacting GYF Protein-2 (GIGYF2) is a candidate gene for PARK11 locus. To date, seven different GIGYF2 missense mutations have been identified in patients with familial Parkinson disease (PD) of European descent...
  27. dos Santos A, Pestana C, Diniz K, Campos M, Abdalla Carvalho C, de Rosso A, et al. Mutational analysis of GIGYF2, ATP13A2 and GBA genes in Brazilian patients with early-onset Parkinson's disease. Neurosci Lett. 2010;485:121-4 pubmed publisher
    In the last decade, several genes have been linked to Parkinson's disease (PD), including GIGYF2, ATP13A2 and GBA...
  28. Tan E, Lin C, Tai C, Tan L, Chen M, Li R, et al. Non-synonymous GIGYF2 variants in Parkinson's disease from two Asian populations. Hum Genet. 2009;126:425-30 pubmed publisher
    Mutations in the GIGYF2 gene at the PARK11 locus have recently been reported in Parkinson's disease (PD). However, the pathogenicity of some of these mutations has been debated...
  29. Kofler M, Motzny K, Freund C. GYF domain proteomics reveals interaction sites in known and novel target proteins. Mol Cell Proteomics. 2005;4:1797-811 pubmed
    ..The binding epitope of the GYF domain from the yeast SMY2 protein was mapped by NMR spectroscopy and led to a structural model that accounts for the different binding properties of SMY2-type GYF domains and the CD2BP2-GYF domain. ..
  30. Huo Z, Luo X, Zhan X, Chu Q, Xu Q, Yao J, et al. Genetic analysis of indel markers in three loci associated with Parkinson's disease. PLoS ONE. 2017;12:e0184269 pubmed publisher
    ..indels) to the risk of PD in a Chinese population, we performed genetic analyses of indel loci in ACE, DJ-1, and GIGYF2 genes...
  31. Vilariño Güell C, Ross O, Soto A, Farrer M, Haugarvoll K, Aasly J, et al. Reported mutations in GIGYF2 are not a common cause of Parkinson's disease. Mov Disord. 2009;24:619-20 pubmed publisher
  32. Tian J, Guo J, Wang L, Sun Q, Yao L, Luo L, et al. Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease. Neurosci Lett. 2012;516:207-11 pubmed publisher
    ..dorminant Parkinson's disease (ADPD) has been associated with mutations in the SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes...
  33. Bonifati V. Is GIGYF2 the defective gene at the PARK11 locus?. Curr Neurol Neurosci Rep. 2009;9:185-7 pubmed
    ..Among the most interesting findings of the year was the nomination of GIGYF2 as the gene that is defective at the PARK11 locus and is a potentially frequent cause of typical Parkinson's ..
  34. Samaranch L, Lorenzo E, Pastor M, Riverol M, Luquin M, Rodriguez Oroz M, et al. Analysis of the GIGYF2 gene in familial and sporadic Parkinson disease in the Spanish population. Eur J Neurol. 2010;17:321-5 pubmed publisher
    Linkage analysis in familial Parkinson's disease (PD) identified a locus in 2q36-37 (PARK11). Sequencing of GIGYF2 identified several variants only present amongst PD individuals...
  35. Tan E, Schapira A. Summary of GIGYF2 studies in Parkinson's disease: the burden of proof. Eur J Neurol. 2010;17:175-6 pubmed publisher
  36. Ajiro M, Nishidate T, Katagiri T, Nakamura Y. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Int J Oncol. 2010;37:1085-93 pubmed
    ..in mammary carcinogenesis through the interaction with Grb10 interacting GYF protein 1 (GIGYF1), Grb10 interacting GYF protein 2 (GIGYF2) and growth factor receptor binding protein 10 (Grb10)...
  37. Nichols W, Kissell D, Pankratz N, Pauciulo M, Elsaesser V, Clark K, et al. Variation in GIGYF2 is not associated with Parkinson disease. Neurology. 2009;72:1886-92 pubmed publisher
    A recent study reported that mutations in a gene on chromosome 2q36-37, GIGYF2, result in Parkinson disease (PD)...
  38. Higashi S, Iseki E, Minegishi M, Togo T, Kabuta T, Wada K. GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. J Neurochem. 2010;115:423-37 pubmed publisher
    ..Heterozygous knockout of GIGYF2 results in neurodegeneration, suggesting important roles for GIGYF2 (Grb10 interacting GYF protein 2) in the CNS...
  39. Morita M, Ler L, Fabian M, Siddiqui N, Mullin M, Henderson V, et al. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012;32:3585-93 pubmed publisher
    ..In this study, we have identified the Grb10-interacting GYF protein 2 (GIGYF2) and the zinc finger protein 598 (ZNF598) as components of the m4EHP complex...
  40. Wang L, Guo J, Zhang W, Xu Q, Zuo X, Shi C, et al. Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population. Neurosci Lett. 2010;473:131-5 pubmed publisher
    ..Grb10-Interacting GYF Protein-2 gene (GIGYF2), located in the chromosomal region 2q36-q37, has been reported as a PARK11 gene with a causal role in familial Parkinson's disease (PD) in Italian and French populations...