GFRA1

Summary

Gene Symbol: GFRA1
Description: GDNF family receptor alpha 1
Alias: GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha-1, GDNFR-alpha-1, GPI-linked anchor protein, Glial cell line-derived neurotrophic factor receptor alpha, PI-linked cell-surface accessory protein, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1
Species: human
Products:     GFRA1

Top Publications

  1. Esseghir S, Todd S, Hunt T, Poulsom R, Plaza Menacho I, Reis Filho J, et al. A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer Res. 2007;67:11732-41 pubmed
    ..tumors, we have shown that the receptor tyrosine kinase RET (REarranged during Transfection) and its coreceptor GFR alpha 1 (GDNF receptor family alpha-1) are overexpressed in a subset of estrogen receptor-positive tumors...
  2. Koh Y, Chun S, Park Y, Song J, Lee G, Khang S, et al. Association between the CpG island methylator phenotype and its prognostic significance in primary pulmonary adenocarcinoma. Tumour Biol. 2016;37:10675-84 pubmed publisher
    ..pulmonary adenocarcinoma after a surgical resection, we performed methylation analysis of six genes (CCNA1, ACAN, GFRA1, EDARADD, MGC45800, and p16 (INK4A)) in 230 pulmonary adenocarcinoma cases using the SEQUENOM MassARRAY platform...
  3. Zhang H, Bagherie Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, et al. FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Dev Cell. 2019;: pubmed publisher
    ..Importantly, expression of FAT4 perturbs the assembly of the RET-GFRA1-GDNF complex, reducing RET signaling...
  4. Masaki K, Sakai M, Kuroki S, Jo J, Hoshina K, Fujimori Y, et al. FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche. Stem Cell Reports. 2018;10:1782-1792 pubmed publisher
    ..Although both factors expanded the GFRA1+ subset of undifferentiated spermatogonia, the FGF2-expanded subset expressed RARG, which is ..
  5. Sigurdson A, Land C, Bhatti P, Pineda M, Brenner A, Carr Z, et al. Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. Radiat Res. 2009;171:77-88 pubmed publisher
    ..Elevated thyroid nodule risks were associated with the minor alleles of RET S836S (rs1800862, P = 0.03) and GFRA1 -193C>G (rs not assigned, P = 0.05) and decreased risk with XRCC1 R194W (rs1799782, P trend = 0...
  6. Honne K, Hallgrímsdóttir I, Wu C, Sebro R, Jewell N, Sakurai T, et al. A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis. Arthritis Res Ther. 2016;18:12 pubmed publisher
    ..Potential candidate genes in these regions include MAP3K7, BACH2 (6q15), GFRA1 (10q25.3), and WDR27 (6q27). The association at GFRA1 replicates a previous finding from a Caucasian dataset...
  7. Porokuokka L, Virtanen H, Lindén J, Sidorova Y, Danilova T, Lindahl M, et al. Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice. Cell Mol Gastroenterol Hepatol. 2019;7:655-678 pubmed publisher
    ..GDNF family receptor alpha-1 (GFRa1) hypomorphic mice were generated by placing a selectable marker gene in the sixth intron of the Gfra1 locus using ..
  8. Sharma M, Braun R. Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. Development. 2018;145: pubmed publisher
    ..Stage-specific ectopic expression of GDNF caused the accumulation of a GFRA1+ LIN28- Asingle population, which has enhanced SSC activity compared with wild ..
  9. He Z, Kokkinaki M, Jiang J, Zeng W, Dobrinski I, Dym M. Isolation of human male germ-line stem cells using enzymatic digestion and magnetic-activated cell sorting. Methods Mol Biol. 2012;825:45-57 pubmed publisher
    ..We have recently isolated human G protein-coupled receptor 125 (GPR125)-positive spermatogonia and GDNF family receptor alpha 1 (GFRA1)-positive spermatogonia using a 2-step enzymatic digestion and magnetic-activated cell sorting (..

More Information

Publications115 found, 100 shown here

  1. Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, et al. Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1. Glia. 2015;63:780-94 pubmed publisher
    ..Taken together, these data suggest that FABP7 controls lipid raft function through the regulation of caveolin-1 expression and is involved in the response of astrocytes to the external stimuli. GLIA 2015;63:780-794. ..
  2. Song W, Mu H, Wu J, Liao M, Zhu H, Zheng L, et al. miR-544 Regulates Dairy Goat Male Germline Stem Cell Self-Renewal via Targeting PLZF. J Cell Biochem. 2015;116:2155-65 pubmed publisher
    ..mGSCs; the cells proliferation was evaluated by BRDU incorporation assay and flow cytometry, and the mGSC marker, GFRa1, PLZF, KIT, DAZL, and VASA expression were analyzed by RT-qPCR, immunofluorescence and Western blot...
  3. Gao D, Zhang R, Ji G, LI C, Guo D, Jin T, et al. Relative Telomere Length and Stroke Risk in a Chinese Han Population. J Mol Neurosci. 2018;66:475-481 pubmed publisher
    ..RTL) in susceptibility to stroke and investigate the association regulator of telomere elongation helicase 1 (RETL1) gene polymorphisms and RTL...
  4. Hou J, Niu M, Liu L, Zhu Z, Wang X, Sun M, et al. Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation. Sci Rep. 2015;5:16922 pubmed publisher
    ..this cell line was positive for a number of human spermatogonial and SSC hallmarks, including VASA, DAZL, MAGEA4, GFRA1, RET, UCHL1, GPR125, PLZF and THY1, suggesting that these cells are human SSCs phenotypically...
  5. Li L, Wang M, Geng L, Xue Y, Wei X, Jia Y, et al. A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cells. Cell Death Dis. 2016;7:e2140 pubmed publisher
    ..LncRNA033862 is an antisense transcript of the GDNF receptor alpha1 (Gfra1) that lacks protein coding potential and regulates Gfra1 expression levels by interacting with Gfra1 chromatin...
  6. Zechel S, Fernández Suárez D, Ibanez C. Cell-autonomous role of GFR?1 in the development of olfactory bulb GABAergic interneurons. Biol Open. 2018;7: pubmed publisher
    ..The olfactory bulb (OB) of Gfra1 knockout mice shows significant reductions in the number of olfactory sensory neurons, mitral and tufted cells, as ..
  7. Fan T, Yeo H, Hsu H, Yu J, Ho M, Lin W, et al. Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells. Cancer Lett. 2018;434:184-195 pubmed publisher
    b>GFRA1 and RET are overexpressed in estrogen receptor (ER)-positive breast cancers. Binding of GDNF to GFRA1 triggers RET signaling leading to ER phosphorylation and estrogen-independent transcriptional activation of ER-dependent genes...
  8. Bellaïche J, Goupil A, Sambroni E, Lareyre J, Le Gac F. Gdnf-Gfra1 pathway is expressed in a spermatogenetic-dependent manner and is regulated by Fsh in a fish testis. Biol Reprod. 2014;91:94 pubmed publisher
    ..In the present study, we focus on the Gdnf-Gfra1 pathway that plays a major role in the regulation of SSC self-renewal in mammals...
  9. Chen S, Liu Y. Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. Reproduction. 2015;149:R159-67 pubmed publisher
    ..Other transcription factors and signaling pathways (GDNF-RET-GFRA1 signaling, FGF2-MAP2K1 signaling, CXCL12-CXCR4 signaling, CCL9-CCR1 signaling, FSH-nociceptin/OPRL1, retinoic acid/..
  10. Kim M, Kim D. GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance. Int J Mol Sci. 2018;19: pubmed publisher
    ..Of the four identified GFRA isoforms, GFRA1 specifically recognizes GDNF and is involved in the regulation of proliferation, differentiation, and migration of ..
  11. Huber R, Lucas J, Gomez Sarosi L, Coleman I, Zhao S, Coleman R, et al. DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance. Oncotarget. 2015;6:2134-47 pubmed
    ..cell proliferation and invasion, and these effects were concordant with the expression of known GDNF receptors GFRA1 and RET. Exposure to GDNF also induced tumor cell resistance to mitoxantrone and docetaxel chemotherapy...
  12. Bye C, Jönsson M, Björklund A, Parish C, Thompson L. Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015;112:E1946-55 pubmed publisher
    ..proteins with high expression in mDA progenitors and describe the utility of four of these targets (Alcam, Chl1, Gfra1, and Igsf8) for isolating mDA progenitors from rat primary ventral mesencephalon through flow cytometry...
  13. Marks C, Belluscio L, Ibáñez C. Critical role of GFRα1 in the development and function of the main olfactory system. J Neurosci. 2012;32:17306-20 pubmed publisher
    ..The OE of newborn Gfra1 knock-out mice was thinner and contained fewer OSNs, but more dividing precursors, suggesting deficient ..
  14. Takashima S, Kanatsu Shinohara M, Tanaka T, Morimoto H, Inoue K, Ogonuki N, et al. Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. Stem Cell Reports. 2015;4:489-502 pubmed publisher
    ..that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor...
  15. Giassetti M, Goissis M, de Barros F, Bruno A, Assumpção M, Visintin J. Comparison of Diverse Differential Plating Methods to Enrich Bovine Spermatogonial Cells. Reprod Domest Anim. 2016;51:26-32 pubmed publisher
    ..Recovered cells were analysed for the expression of SSC molecular markers by quantitative RT-PCR (GFRA1, CXCR4, ITGA6, THY1) and flow cytometry (GFRA1, CXCR4 and ITGA6)...
  16. Lara N, Costa G, Avelar G, Guimaraes D, Franca L. Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche. Gen Comp Endocrinol. 2019;273:98-107 pubmed publisher
    ..Almost all gonocytes and SSCs expressed Nanos1, Nanos2 and GFRA1. The analysis of SSCs preferential location indicated that the establishment of SSCs niche is coincident with the ..
  17. Kakiuchi K, Taniguchi K, Kubota H. Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis. Sci Rep. 2018;8:7656 pubmed publisher
    ..Furthermore, GDNF expression was localised to the vascular smooth muscle cells, and its cognate receptor GFRA1 expression was negligible during spermatogonial proliferation in the testes...
  18. Fayomi A, Orwig K. Spermatogonial stem cells and spermatogenesis in mice, monkeys and men. Stem Cell Res. 2018;29:207-214 pubmed publisher
    ..g., Asingle, Apaired or Aaligned spermatogonia), molecular markers (e.g., ID4, GFRA1, PLZF, SALL4 and others) and most importantly by their biological potential to produce and maintain ..
  19. Kholodilov N, Kim S, Yarygina O, Kareva T, Cho J, Baohan A, et al. Glial cell line-derived neurotrophic factor receptor-?1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem. 2011;116:486-98 pubmed publisher
    ..We conclude that post-synaptic striatal GFR?1 expression has important effects on the biology of dopamine neurons in vivo. ..
  20. Hasegawa K, Saga Y. FGF8-FGFR1 signaling acts as a niche factor for maintaining undifferentiated spermatogonia in the mouse. Biol Reprod. 2014;91:145 pubmed publisher
    ..Undifferentiated spermatogonia comprise GFRA1(+) and NANOS3(+) subpopulations, which are likely to undergo self-renewal and enter the differentiation pathway, ..
  21. Rivero J, Henríquez Hernández L, Luzardo O, Pestano J, Zumbado M, Boada L, et al. Differential gene expression pattern in human mammary epithelial cells induced by realistic organochlorine mixtures described in healthy women and in women diagnosed with breast cancer. Toxicol Lett. 2016;246:42-8 pubmed publisher
    ..Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2)...
  22. Barrenschee M, Wedel T, Lange C, Hohmeier I, Cossais F, Ebsen M, et al. No neuronal loss, but alterations of the GDNF system in asymptomatic diverticulosis. PLoS ONE. 2017;12:e0171416 pubmed publisher
    ..ganglia from patients with diverticulosis, DD and controls were analyzed for mRNA expression levels of GDNF, GFRA1, and RET by RT-qPCR...
  23. Nickkholgh B, Korver C, van Daalen S, van Pelt A, Repping S. AZFc deletions do not affect the function of human spermatogonia in vitro. Mol Hum Reprod. 2015;21:553-62 pubmed publisher
    ..and BTB domain containing 16 (ZBTB16) and glial cell line-derived neurotrophic factor family receptor alpha 1 (GFRA1), as well as germ cell differentiation markers including signal transducer and activator of transcription 3 (STAT3)..
  24. Costa G, Sousa A, Figueiredo A, Lacerda S, França L. Characterization of spermatogonial cells and niche in the scorpion mud turtle (Kinosternon scorpioides). Gen Comp Endocrinol. 2019;273:163-171 pubmed publisher
    ..Similar to some mammalian and fish species investigated, both GFRA1 and CSF1 receptors were expressed in Aund/SSCs in K. scorpioides. Also, as K...
  25. Maouche A, Curran E, Goupil A, Sambroni E, Bellaiche J, Le Gac F, et al. New insights into the evolution, hormonal regulation, and spatiotemporal expression profiles of genes involved in the Gfra1/Gdnf and Kit/Kitlg regulatory pathways in rainbow trout testis. Fish Physiol Biochem. 2018;44:1599-1616 pubmed publisher
    The present study aimed to investigate whether the Gfra1/Gdnf and/or Kit/Kitlg regulatory pathways could be involved in the regulation of spermatogonial cell proliferation and/or differentiation in fish...
  26. Niedenberger B, Busada J, Geyer C. Marker expression reveals heterogeneity of spermatogonia in the neonatal mouse testis. Reproduction. 2015;149:329-38 pubmed publisher
    ..b>GFRA1, which was present in nearly all prospermatogonia at P1, was only retained in STRA8/KIT- spermatogonia...
  27. Giassetti M, Goissis M, Moreira P, de Barros F, Assumpção M, Visintin J. Effect of age on expression of spermatogonial markers in bovine testis and isolated cells. Anim Reprod Sci. 2016;170:68-74 pubmed publisher
    ..molecular markers by qRT-PCR (POU5F1, GDNF, CXCR4, UCHL1, ST3GAL, SELP, ICAM1 and ITGA6) and flow cytometry (GFRA1, CXCR4 and ITGA6). CXCR4 and UCHL1 expression was evaluated in fixated testes by immunohistochemistry...
  28. Adly M, Assaf H, Hussein M. Age-associated decrease in GDNF and its cognate receptor GFR?-1 protein expression in human skin. Int J Exp Pathol. 2016;97:248-56 pubmed publisher
    ..Our findings suggest that the consequences of this is that GFR?-1-mediated signalling is altered during the ageing process. The clinical and therapeutic ramifications of these observations mandate further investigations. ..
  29. Bhakta S, Crocker L, Chen Y, Hazen M, Schutten M, Li D, et al. An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer. Mol Cancer Ther. 2018;17:638-649 pubmed publisher
    ..we have identified and characterized Glial cell line-Derived Neurotrophic Factor (GDNF) Family Receptor Alpha 1 (GFRA1) antibody-drug conjugates (ADC) using a cleavable valine-citrulline-MMAE (vcMMAE) linker-payload...
  30. Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, et al. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clin Cancer Res. 2014;20:4598-612 pubmed publisher
    ..05) and confirmed using bisulfite sequencing. These genes included BMP3, BNIP3, CDKN2A, ECEL1, ELK1, GFRA1, HOXD10, KCNH1, PSMD10, PTPRT, SIGIRR, SRF, TBX5, TFPI2, and ZNF382...
  31. Vansandt L, Livesay J, Dickson M, Li L, Pukazhenthi B, Keefer C. Conservation of spermatogonial stem cell marker expression in undifferentiated felid spermatogonia. Theriogenology. 2016;86:1022-1035.e3 pubmed publisher
    ..in the domestic cat (Felis catus), the expression both in situ and following enrichment in vitro of six genes (GFRA1, GPR125, ZBTB16, POU5F1, THY1, and UCHL1) that had been previously identified as SSC markers in other species...
  32. Evans R, Pottala J, Nagata S, Egland K. Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality. BMC Cancer. 2018;18:119 pubmed publisher
    ..For these three treatment groups, autoantibody responses against 9 TAAs (A1AT, ANGPTL4, CAPC, CST2, DKK1, GFRA1, GRN, LGALS3 and LRP10) were significantly reduced at 12 months after surgery compared to before treatment...
  33. Wang D, Zhou H, Liu S, Zhou C, Kong X, Han Z, et al. Glial cell line-derived neurotrophic factor supplementation promotes bovine in vitro oocyte maturation and early embryo development. Theriogenology. 2018;113:92-101 pubmed publisher
    ..We show for the first time that GDNF and its receptor, GDNF family receptor alpha-1 (GFRA1), are presented in ovarian follicles at different stages as well as during oocyte maturation and early embryo ..
  34. Parkash V, Leppänen V, Virtanen H, Jurvansuu J, Bespalov M, Sidorova Y, et al. The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. J Biol Chem. 2008;283:35164-72 pubmed publisher
    ..neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor GDNF family receptor alpha1 (GFR alpha 1) in a 2:2 ratio and signals through the receptor tyrosine kinase RET. We have solved the GDNF(2)...
  35. Miao H, Miao C, Li N, Han J. FOXJ2 controls meiosis during spermatogenesis in male mice. Mol Reprod Dev. 2016;83:684-91 pubmed publisher
    ..Spata22, Eif4g3, and Zpac); in contrast, no change was observed in the expression of spermatogonia markers (Gfra1, Zbtb16, and c-Kit) and germ cell markers (Dazl, Mvh, and Tra98)...
  36. Agopiantz M, Xandre Rodriguez L, Jin B, Urbistondoy G, Ialy Radio C, Chalbi M, et al. Growth arrest specific 1 (Gas1) and glial cell line-derived neurotrophic factor receptor α1 (Gfrα1), two mouse oocyte glycosylphosphatidylinositol-anchored proteins, are involved in fertilisation. Reprod Fertil Dev. 2017;29:824-837 pubmed publisher
    ..After bibliographic and database searches we selected five GIP-anchored proteins (Cpm, Ephrin-A4, Gas1, Gfra1 and Rgmb) as potential oocyte candidates participating in fertilisation...
  37. Guo Y, Liu L, Sun M, Hai Y, Li Z, He Z. Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways. Exp Biol Med (Maywood). 2015;240:1112-22 pubmed publisher
    ..These freshly isolated cells expressed a number of markers for SSCs, including GPR125, PLZF, GFRA1, RET, THY1, UCHL1 and MAGEA4, but not the hallmarks for spermatocytes and spermatozoa, e.g...
  38. Nivlet L, Herrmann J, Martin D, Meunier A, Orvain C, Gradwohl G. Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas. J Mol Endocrinol. 2016;56:77-90 pubmed publisher
    ..this context, the aim of the study was to determine the expression and function of the glial cell line derived neurotrophic factor receptor alpha 3 (GFRα3) and its ligand artemin (Artn) in islet cell development and function...
  39. Mu S, Han L, Zhou G, Mo C, Duan J, He Z, et al. Protein regulation of induced pluripotent stem cells by transplanting in a Huntington's animal model. Neuropathol Appl Neurobiol. 2016;42:521-34 pubmed publisher
    ..The findings in this work indicate that transplantation of induced pluripotent stem cells is a promising therapeutic candidate for HD. ..
  40. Ma F, Zhou Z, Li N, Zheng L, Wu C, Niu B, et al. Lin28a promotes self-renewal and proliferation of dairy goat spermatogonial stem cells (SSCs) through regulation of mTOR and PI3K/AKT. Sci Rep. 2016;6:38805 pubmed publisher
    ..Moreover, Lin28a maintained the self-renewal of GmGSCs-I-SB by up-regulating the expression of OCT4, SOX2, GFRA1, PLZF and ETV5...
  41. Pui H, Saga Y. NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes. Mech Dev. 2018;149:27-40 pubmed publisher
    ..in terms of the expression pattern of at least three early spermatogonial marker genes namely Nanos2, Stra8 and Gfra1. NANOS2 expression levels are negatively correlated with those of STRA8 and GFRA1 before GST, while positive ..
  42. Kjaer S, Ibanez C. Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. J Biol Chem. 2003;278:47898-904 pubmed
    ..Cross-linking experiments have indicated that the RETECD makes direct contacts with both the GDNF ligand and GFR alpha 1 molecule in the complex, although it has low or no detectable affinity for either component alone...
  43. Yang B, Heng L, Du S, Yang H, Jin T, Lang H, et al. Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study. Med Sci Monit. 2015;21:1983-8 pubmed publisher
    ..Our results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population.
  44. Pieri N, Souza A, Mançanares A, Roballo K, Casals J, Ambrosio C, et al. Immunolocalization of proteins in the spermatogenesis process of canine. Reprod Domest Anim. 2017;52 Suppl 2:170-176 pubmed publisher
    ..Glial cell-derived neurotrophic factor family receptor alpha-1 (GFRA1), deleted in azoospermia-like (DAZL) and promyelocytic leukaemia zinc finger (PLZF) were expressed in SSCs, while ..
  45. Pramod R, Lee B, Kim Y, Lee H, Park Y, Ono T, et al. Isolation, Characterization, and In Vitro Culturing of Spermatogonial Stem Cells in Japanese Quail (Coturnix japonica). Stem Cells Dev. 2017;26:60-70 pubmed publisher
    ..immunohistochemical evaluation indicated the expression of integrin alpha-6 (ITGA6), GDNF family receptor alpha-1 (GFRA1), and Deleted in azoospermia-like (DAZL) in specific TCs...
  46. Eng C, Myers S, Kogon M, Sanicola M, Hession C, Cate R, et al. Genomic structure and chromosomal localization of the human GDNFR-alpha gene. Oncogene. 1998;16:597-601 pubmed
    b>GDNFR-alpha is a glycosyl-phosphotidylinositol-linked receptor for glial cell line-derived neurotrophic factor (GDNF)...
  47. Japon M, Urbano A, Saez C, Segura D, Cerro A, Dieguez C, et al. Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors. J Clin Endocrinol Metab. 2002;87:1879-84 pubmed
    ..The expression of RET in all of the somatotropinomas and in 50% of the ACTH-producing tumors implies that GDNF and RET could be involved in the pathogenesis of pituitary tumors. ..
  48. Chatterjee R, Ramos E, Hoffman M, Vanwinkle J, Martin D, Davis T, et al. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131:1725-38 pubmed publisher
    ..We provide evidence for the coexistence of deleterious rare and common variants in genes in the same pathway as a cause of CAKUT and discovered novel phenotypes associated with the RET pathway...
  49. Kim M, Jung J, Choi S, Lee H, Morales L, Koh J, et al. GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy. Autophagy. 2017;13:149-168 pubmed publisher
    ..In this study, we show that GFRA1/GFR?1 (GDNF family receptor ? 1), contributes to cisplatin-induced chemoresistance by regulating autophagy in ..
  50. Hase A, Suzuki H, Arahata K, Akazawa C. Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves. Neurosci Lett. 1999;269:55-7 pubmed
    ..The results suggested that GFR alpha-1 might play a key role for uptake and internalization of GDNF at the human NMJ. ..
  51. Lui V, Samy E, Sham M, Mulligan L, Tam P. Glial cell line-derived neurotrophic factor family receptors are abnormally expressed in aganglionic bowel of a subpopulation of patients with Hirschsprung's disease. Lab Invest. 2002;82:703-12 pubmed
    ..In normal infants and normoganglionic colon of patients with HSCR, the expression of GFRA1 was restricted to the glial cells and neurones of the ganglion plexuses...
  52. Borrego S, Fernandez R, Dziema H, Japon M, Marcos I, Eng C, et al. Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer. Thyroid. 2002;12:1017-22 pubmed
    ..In this study, we have genotyped nine polymorphisms within GFRA1-3 genes for 51 Spanish sMTC, and 100 normal controls...
  53. Tsui C, Gabreski N, Hein S, Pierchala B. Lipid Rafts Are Physiologic Membrane Microdomains Necessary for the Morphogenic and Developmental Functions of Glial Cell Line-Derived Neurotrophic Factor In Vivo. J Neurosci. 2015;35:13233-43 pubmed publisher
    ..Here we demonstrate, using a knock-in mouse model in which GFRα1 is no longer located in lipid rafts, that the developmental functions of GDNF in the periphery require the translocation of the GDNF receptor complex into lipid rafts. ..
  54. Catela C, Shin M, Lee D, Liu J, Dasen J. Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes. Cell Rep. 2016;14:1901-15 pubmed publisher
  55. Sergaki M, Ibanez C. GFR?1 Regulates Purkinje Cell Migration by Counteracting NCAM Function. Cell Rep. 2017;18:367-379 pubmed publisher
    ..Genetic reduction of NCAM expression enhances wild-type PC migration and restores migration in Gfra1 mutants, indicating that NCAM restricts PC migration in the embryonic cerebellum...
  56. Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi F, et al. Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. Blood. 1997;89:2925-37 pubmed
    ..neurotrophic factor (GDNF), in which a novel glycosyl-phosphatidylinositol (PI)-linked protein (termed GDNFR-alpha) acts as the ligand-binding component...
  57. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci U S A. 1997;94:6238-43 pubmed
    ..Activation of RET by GDNF has been shown to require an accessory component, GDNFR-alpha (RETL1)...
  58. Borrego S, Fernandez R, Dziema H, Niess A, Lopez Alonso M, Antinolo G, et al. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. J Med Genet. 2003;40:e18 pubmed
  59. Zhang H, Zhang R, Luo Y, D Alessio A, Pober J, Min W. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 2004;279:44955-65 pubmed
    ..Taken together, our data suggest that AIP1 is a novel transducer in TNF-induced TRAF2-dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling. ..
  60. Wu Z, Pandey V, Wu W, Ye S, Zhu T, Lobie P. Prognostic significance of the expression of GFR?1, GFR?3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma. BMC Cancer. 2013;13:34 pubmed publisher
    ..The expression of GFR?1 and/or GFR?3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma. ..
  61. Cik M, Masure S, Lesage A, Van Der Linden I, Van Gompel P, Pangalos M, et al. Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. J Biol Chem. 2000;275:27505-12 pubmed
    ..These results suggest an interaction of GFRalpha1 and cRET in the absence of GDNF and demonstrate that the high affinity binding can be measured only when cRET is present. ..
  62. Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, et al. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron. 2001;29:171-84 pubmed
    ..These results provide an explanation for the tissue distribution of GFRalpha1, supporting the physiological importance of c-Ret activation in trans as a novel mechanism to potentiate and diversify the biological responses to GDNF. ..
  63. Paratcha G, Ledda F, Ibanez C. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell. 2003;113:867-79 pubmed
    ..These results uncover an unexpected intersection between short- and long-range mechanisms of intercellular communication and reveal a pathway for GDNF signaling that does not require the RET receptor. ..
  64. Bing Z, Pasha T, Lal P, Tomaszewski J. Expression of glial cell line-derived neurotropic factor receptor alpha-1 in immature teratomas. Am J Clin Pathol. 2008;130:892-6 pubmed publisher
    ..Immunohistochemical staining for GFRalpha-1 in immature neuroepithelium may facilitate its identification. ..
  65. He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, et al. circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. J Exp Clin Cancer Res. 2017;36:145 pubmed publisher
    ..Via luciferase reporter assays, circGFRA1 and GFRA1 was observed to directly bind to miR-34a...
  66. Jing S, Yu Y, Fang M, Hu Z, Holst P, Boone T, et al. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 1997;272:33111-7 pubmed
    ..Consistent with a role in GDNF function, the GFRalphas and Ret are expressed in many of the same tissues, suggesting that GFRalphas mediate the action of GDNF family ligands in vivo. ..
  67. Gorodinsky A, Zimonjic D, Popescu N, Milbrandt J. Assignment of the GDNF family receptor alpha-1 (GFRA1) to human chromosome band 10q26 by in situ hybridization. Cytogenet Cell Genet. 1997;78:289-90 pubmed
  68. Enokido Y, de Sauvage F, Hongo J, Ninkina N, Rosenthal A, Buchman V, et al. GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr Biol. 1998;8:1019-22 pubmed
    ..These results demonstrate that GFR alpha-4 is the ligand-binding subunit for persephin and that persephin, like GDNF and neurturin, also requires Ret for signalling. ..
  69. Tansey M, Baloh R, Milbrandt J, Johnson E. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron. 2000;25:611-23 pubmed
    ..Therefore, proper membrane localization of RET via interaction with a raft-localized, GPI-linked coreceptor is of fundamental importance in GFL signaling. ..
  70. Bäckman C, Shan L, Zhang Y, Hoffer B, Leonard S, Troncoso J, et al. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Mol Cell Endocrinol. 2006;252:160-6 pubmed
    ..No significant changes were observed for the expression of cRet and GFRa1. These data suggest that the extensive loss of dopaminergic neurons in the substantia nigra, and concomitant loss ..
  71. Alfano I, Vora P, Mummery R, Mulloy B, Rider C. The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding. Biochem J. 2007;404:131-40 pubmed
    ..The role of heparin and heparan sulfate in GDNF signalling remains unclear, but the present study indicates that it does not occur in the first step of the pathway, namely GDNF-GFRalpha1 engagement. ..
  72. Pini Prato A, Musso M, Ceccherini I, Mattioli G, Giunta C, Ghiggeri G, et al. Hirschsprung disease and congenital anomalies of the kidney and urinary tract (CAKUT): a novel syndromic association. Medicine (Baltimore). 2009;88:83-90 pubmed publisher
    ..These results need to be confirmed in a larger series. At present, we strongly suggest considering ultrasound screening of the urinary tract in every patient with a diagnosis of HSCR. ..
  73. Barrenschee M, Bottner M, Hellwig I, Harde J, Egberts J, Becker T, et al. Site-specific gene expression and localization of growth factor ligand receptors RET, GFR?1 and GFR?2 in human adult colon. Cell Tissue Res. 2013;354:371-80 pubmed publisher
    ..Signal transduction is mediated by a receptor complex composed of GDNF family receptor alpha 1 (GFR?1) for GDNF or GFR?2 for NRTN, together with the tyrosine kinase receptor RET (rearranged during ..
  74. Treanor J, Goodman L, de Sauvage F, Stone D, Poulsen K, Beck C, et al. Characterization of a multicomponent receptor for GDNF. Nature. 1996;382:80-3 pubmed
    ..responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-alpha) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity...
  75. López Ramírez M, Domínguez Monzón G, Vergara P, Segovia J. Gas1 reduces Ret tyrosine 1062 phosphorylation and alters GDNF-mediated intracellular signaling. Int J Dev Neurosci. 2008;26:497-503 pubmed publisher
    ..The results of this work are consistent with the hypothesis of Gas1 acting as a negative modulator of GDNF signaling. ..
  76. Kim M, Kim H, Acharya S, Sohn H, Jun J, Chang I, et al. Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression. Mol Cell Biol. 2009;29:2264-77 pubmed publisher
  77. He S, Chen C, Chernichenko N, He S, Bakst R, Barajas F, et al. GFR?1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. Proc Natl Acad Sci U S A. 2014;111:E2008-17 pubmed publisher
    ..These results advance a mechanistic understanding of PNI and implicate the nerve itself as a key facilitator of this adverse cancer cell behavior. ..
  78. Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, et al. GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep. 2016;16:1026-1038 pubmed publisher
    ..Collectively, our findings establish a platform for investigating the biology of CPs as a foundation for future development of CP transplantation for treating heart failure. ..
  79. Cabrera J, Sanchez Pulido L, Rojas A, Valencia A, Manes S, Naranjo J, et al. Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling. J Biol Chem. 2006;281:14330-9 pubmed
    ..Consequently, when Gas1 is induced, Ret-mediated GDNF-dependent survival effects are compromised. ..
  80. Severskaia N, Saenko V, Il in A, Chebotareva I, Rumiantsev P, Isaev P, et al. [RET and GFRA1 germline polymorphisms in medullary thyroid cancer patients]. Mol Biol (Mosk). 2006;40:425-35 pubmed
    The role of RET and GFRA1 germline polymorphisms in predisposition to sporadic medullary thyroid cancer (MTC) and polymorphisms' modulation effect on clinical features of inherited and sporadic MTC were investigated...
  81. Calender A. [Multiple endocrine neoplasia: genetic aspects]. Bull Acad Natl Med. 2010;194:81-95; discussion 95-6 pubmed
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  83. Di Persio S, Saracino R, Fera S, Muciaccia B, Esposito V, Boitani C, et al. Spermatogonial kinetics in humans. Development. 2017;144:3430-3439 pubmed publisher
    ..We suggest that at the start of the spermatogenic lineage there are Ap-d spermatogonia that are GFRA1High, likely including the spermatogonial stem cells...
  84. Klein R, Sherman D, Ho W, Stone D, Bennett G, Moffat B, et al. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature. 1997;387:717-21 pubmed
    ..receptor system composed of a ligand-binding glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-alpha) and the transmembrane protein tyrosine kinase Ret...
  85. Quartu M, Serra M, Boi M, Ferretti M, Lai M, Del Fiacco M. Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain Res. 2007;1173:36-52 pubmed
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    ..These results indicate that direct receptor-receptor interactions are not required for high affinity GDNF binding to NCAM but play an important role in the regulation of NCAM-mediated cell adhesion by GFRalpha1. ..
  87. Souza R, Romano Silva M, Lieberman J, Meltzer H, MacNeil L, Culotti J, et al. Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response. J Psychiatr Res. 2010;44:700-6 pubmed publisher
    ..b>GFRA1, GFRA2 and GFRA3 are located in chromosomal regions with suggestive linkage to schizophrenia...
  88. Liu W, Rask Andersen H. Immunohistological analysis of neurturin and its receptors in human cochlea. Auris Nasus Larynx. 2014;41:172-8 pubmed publisher
    ..NTN and its receptors discovered in current study can be responsible for the unique neuronal survival properties in human spiral ganglion (hSG); a prerequisite for the function of cochlear implants. ..
  89. Wei J, Li G, Zhang J, Zhou Y, Dang S, Chen H, et al. Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer. Oncotarget. 2016;7:62547-62558 pubmed publisher
    ..From the other 26 novel marker genes, GFRA1 and GSTM2 were selected for further analysis on the basis of their biological functions...
  90. Jing S, Wen D, Yu Y, Holst P, Luo Y, Fang M, et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell. 1996;85:1113-24 pubmed
    We report the expression cloning and characterization of GDNFR-alpha, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF)...
  91. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, et al. Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics. 1998;48:354-62 pubmed
    ..Recently, GDNF and GFRA1 (GDNF family receptor, also known as GDNFR-alpha), its GPI-linked coreceptor, were demonstrated to be components of a functional ligand for RET...
  92. Shefelbine S, Khorana S, Schultz P, Huang E, Thobe N, Hu Z, et al. Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux. Hum Genet. 1998;102:474-8 pubmed
    ..line-derived neurotrophic factor (GDNF) mediates signaling across the cell membrane by interaction with the RET-GDNFR alpha receptor complex...