GFI1

Summary

Gene Symbol: GFI1
Description: growth factor independent 1 transcriptional repressor
Alias: GFI-1, GFI1A, SCN2, ZNF163, zinc finger protein Gfi-1, growth factor independence-1, growth factor independent 1 transcription repressor, growth factor independent protein 1, zinc finger protein 163
Species: human
Products:     GFI1

Top Publications

  1. Person R, Li F, Duan Z, Benson K, Wechsler J, Papadaki H, et al. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet. 2003;34:308-12 pubmed
    Mice lacking the transcriptional repressor oncoprotein Gfi1 are unexpectedly neutropenic...
  2. Dwivedi P, Anderson P, Omdahl J, Grimes H, Morris H, May B. Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells. Endocr Relat Cancer. 2005;12:351-65 pubmed
    ..Next, we demonstrate a role for the transcription factor growth factor independent-1 (GFI1) in the repression of CYP27B1...
  3. Dahl R, Iyer S, Owens K, Cuylear D, Simon M. The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem. 2007;282:6473-83 pubmed
    ..Our data demonstrate that GFI-1 represses PU.1 activity and that lack of this repression in Gfi-1(-/-) myeloid cells contributes to the observed mixed lineage phenotype. ..
  4. Phelan J, Shroyer N, Cook T, Gebelein B, Grimes H. Gfi1-cells and circuits: unraveling transcriptional networks of development and disease. Curr Opin Hematol. 2010;17:300-7 pubmed publisher
    ..Growth factor independent-1 (Gfi1) is a transcriptional repressor with essential roles in controlling hematopoietic stem cell biology, myeloid and ..
  5. Rodel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, et al. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J. 2000;19:5845-55 pubmed
  6. Doan L, Porter S, Duan Z, Flubacher M, Montoya D, Tsichlis P, et al. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Res. 2004;32:2508-19 pubmed
    Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains...
  7. Kazanjian A, Gross E, Grimes H. The growth factor independence-1 transcription factor: new functions and new insights. Crit Rev Oncol Hematol. 2006;59:85-97 pubmed
    The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood...
  8. Montoya Durango D, Velu C, Kazanjian A, Rojas M, Jay C, Longmore G, et al. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J Biol Chem. 2008;283:32056-65 pubmed publisher
    Growth factor independent-1 (Gfi1) is a zinc finger protein with a SNAG-transcriptional repressor domain. Ajuba is a LIM domain protein that shuttles between the cytoplasm and the nucleus...
  9. Liu Q, Basu S, Qiu Y, Tang F, Dong F. A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A. Oncogene. 2010;29:2843-52 pubmed publisher
    Zinc-finger (ZF) transcriptional repressor growth factor independence 1 (Gfi-1) has an important role in hematopoiesis and inner ear development, and also functions as an oncoprotein that cooperates with c-Myc in lymphomagenesis...

More Information

Publications130 found, 100 shown here

  1. Gilks C, Bear S, Grimes H, Tsichlis P. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol. 1993;13:1759-68 pubmed
    ..In agreement with this, Gfi-1 does not induce the expression of IL-2. Expression of Gfi-1 in 2780d cells following transfer of a Gfi-1/LXSN retrovirus construct contributes to the emergence of the IL-2i phenotype. ..
  2. Zweidler McKay P, Grimes H, Flubacher M, Tsichlis P. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol Cell Biol. 1996;16:4024-34 pubmed
    ..These results suggest that Gfi-1 may play a role in HCMV biology and may contribute to oncogenesis and T-cell activation by repressing the expression of genes that inhibit these processes. ..
  3. Nakazawa Y, Suzuki M, Manabe N, Yamada T, Kihara Negishi F, Sakurai T, et al. Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression. Oncogene. 2007;26:3541-50 pubmed
    The proto-oncoproteins ETS1 and growth factor independent-1 (GFI1) are implicated in cell growth and differentiation in various types of cells, and their deregulated expression is involved in malignant transformation...
  4. Basu S, Liu Q, Qiu Y, Dong F. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Proc Natl Acad Sci U S A. 2009;106:1433-8 pubmed publisher
    ..Our data reveal a mechanism of transcriptional repression by Gfi-1 and may have important implications for understanding the roles of Gfi-1 in normal development and tumorigenesis. ..
  5. Khandanpour C, Thiede C, Valk P, Sharif Askari E, Nuckel H, Lohmann D, et al. A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia. Blood. 2010;115:2462-72 pubmed publisher
    The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation...
  6. Sharif Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau M, Heyd F, et al. Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010;30:3929-42 pubmed publisher
    ..Here, we analyzed the role of the nuclear zinc finger protein Gfi1 in the TLR response using primary bone marrow-derived macrophages...
  7. Saleque S, Kim J, Rooke H, Orkin S. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007;27:562-72 pubmed
    ..Lineage-restricted deployment of these cofactors through interaction with Gfi proteins controls hematopoietic differentiation. ..
  8. Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Gaudreau M, et al. The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Blood. 2012;120:4006-17 pubmed publisher
    The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 3%-7% of whites and increases the risk for acute myeloid leukemia (AML) by 60%...
  9. McGhee L, Bryan J, Elliott L, Grimes H, Kazanjian A, Davis J, et al. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. J Cell Biochem. 2003;89:1005-18 pubmed
    ..These data identify ETO as a partner for Gfi-1 and Gfi-1B, and suggest that Gfi-1 proteins repress transcription through recruitment of histone deacetylase-containing complexes. ..
  10. Duan Z, Zarebski A, Montoya Durango D, Grimes H, Horwitz M. Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. Mol Cell Biol. 2005;25:10338-51 pubmed
    The growth factor independent 1 (Gfi1) transcriptional regulator oncoprotein plays a crucial role in hematopoietic, inner ear, and pulmonary neuroendocrine cell development and governs cell processes as diverse as self-renewal of ..
  11. Jia R, Lan C, Wang X, Gao C. Integrated analysis of gene expression and copy number variations in MET proto?oncogene?transformed human primary osteoblasts. Mol Med Rep. 2017;: pubmed publisher
    ..Therefore, cell cycle?associated genes including E2F1, E2F2, RB1 and CCND1, and cell adhesion?associated genes, such as CDH18 and LAMA1 may be used as diagnosis and/or therapeutic markers for patients with OS...
  12. You L, Li L, Zou J, Yan K, Belle J, Nijnik A, et al. BRPF1 is essential for development of fetal hematopoietic stem cells. J Clin Invest. 2016;126:3247-62 pubmed publisher
    ..BRPF1 deficiency also reduced the expression of multipotency genes, including Slamf1, Mecom, Hoxa9, Hlf, Gfi1, Egr, and Gata3...
  13. Liu L, Pertsemlidis A, Ding L, Story M, Steinberg M, Sebastiani P, et al. Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease. Exp Biol Med (Maywood). 2016;241:706-18 pubmed publisher
    ..In particular, SNP rs4910736 created a binding site for a known transcription repressor GFi1 which is a candidate protein for further investigation...
  14. Masuda M, Li Y, Pak K, Chavez E, Mullen L, Ryan A. The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells. Mol Neurobiol. 2017;54:5414-5426 pubmed publisher
    ..Bioinformatics identified regions of highly conserved sequence outside of the 8.5 kb, which contained POU4F3-, GFI1-, and LHX3-binding sites. These regions may be involved in maintaining POU4F3 expression in adult outer HCs...
  15. Kranc W, Brazert M, Ozegowska K, Nawrocki M, Budna J, Celichowski P, et al. Expression Profile of Genes Regulating Steroid Biosynthesis and Metabolism in Human Ovarian Granulosa Cells-A Primary Culture Approach. Int J Mol Sci. 2017;18: pubmed publisher
    ..Out of those, ten genes, namely STAR, SCAP, POR, SREBF1, GFI1, SEC14L2, STARD4, INSIG1, DHCR7, and IL1B, belong to both groups...
  16. Mehta H, Glaubach T, COREY S. Systems approach to phagocyte production and activation: neutrophils and monocytes. Adv Exp Med Biol. 2014;844:99-113 pubmed publisher
    ..We also review granulocyte colony-stimulating factor (G-CSF) receptor-induced signal transduction pathways, their influence on proliferation and differentiation, and the cooperativity of cytokines and chemokines in this process. ..
  17. Zhang H, Chen Y, Li Y, Zhang T, Ying Z, Su W, et al. l-Threonine improves intestinal mucin synthesis and immune function of intrauterine growth-retarded weanling piglets. Nutrition. 2019;59:182-187 pubmed publisher
    ..supplementation downregulated δ-like 1 and hes family bHLH transcription factor 1, whereas growth factor independence 1 and Kruppel-like factor 4 expression levels were upregulated...
  18. Gerbe F, van Es J, Makrini L, Brulin B, Mellitzer G, Robine S, et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011;192:767-80 pubmed publisher
    ..We show that whereas the ATOH1/MATH1 transcription factor is essential for their differentiation, Neurog3, SOX9, GFI1, and SPDEF are dispensable, which distinguishes these cells from enteroendocrine, Paneth, and goblet cells, and ..
  19. Xu J, Margol A, Shukla A, Ren X, Finlay J, Krieger M, et al. Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015;5:191 pubmed publisher
    ..2, and isochromosome 17, but no structural variations or overexpression of GFI1 or GFI1B...
  20. Tasseff R, Jensen H, Congleton J, Dai D, Rogers K, Sagar A, et al. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Sci Rep. 2017;7:14327 pubmed publisher
    ..These findings, combined with other literature evidence, suggested that reinforcing feedback is central to hyperactive signaling in a diversity of cell fate programs. ..
  21. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, et al. CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer. Cancer Res. 2015;75:4312-21 pubmed publisher
    ..revealed that CCL5 activates CCR3, a highly expressed chemokine receptor on CD4⁺ T cells, and also boosts Gfi1 expression to promote the differentiation of Th2 cells, which enhance the prometastatic activity of tumor-..
  22. Cheng H, Ang H, A El Farran C, Li P, Fang H, Liu T, et al. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat Commun. 2016;7:13396 pubmed publisher
    ..factor Lmo2 implements a hematopoietic programme in fibroblasts by rapidly binding to and upregulating the Hhex and Gfi1 genes within days...
  23. Lewis M, Quint E, Glazier A, Fuchs H, de Angelis M, Langford C, et al. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet. 2009;41:614-8 pubmed publisher
    ..analysis revealed 96 transcripts with significantly altered expression in homozygotes; notably, Slc26a5, Ocm, Gfi1, Ptprq and Pitpnm1 were downregulated...
  24. Riddiford N, Schlosser G. Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. elife. 2016;5: pubmed publisher
    ..g. Sox2, Hes8) and neuronal/sensory differentiation (e.g. Ngn1, Atoh1, Pou4f1, Gfi1) require Six1 and Eya1 for their placodal expression...
  25. Mencarelli C, Pichaud F. Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina. PLoS Genet. 2015;11:e1005303 pubmed publisher
    ..We demonstrate that during this process, otd and the R8-specific transcription factor senseless/Gfi1 (sens) function as independent transcriptional inputs that are required for the expression of fmi, gogo and the ..
  26. Blyth K, Terry A, Mackay N, Vaillant F, Bell M, Cameron E, et al. Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene. 2001;20:295-302 pubmed
    ..frequency of rearrangement at c-Myc or N-Myc (82%), and a significant number at Pim1 or Pim2 (23%), and at Pal1/Gfi1 (18%)...
  27. Zohren F, Souroullas G, Luo M, Gerdemann U, Imperato M, Wilson N, et al. The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nat Immunol. 2012;13:761-9 pubmed publisher
    ..We identified Gfi1 as a critical transcriptional target of Lyl-1-mediated lymphopoiesis of T cells...
  28. de Vocht F, Simpkin A, Richmond R, Relton C, Tilling K. Assessment of Offspring DNA Methylation across the Lifecourse Associated with Prenatal Maternal Smoking Using Bayesian Mixture Modelling. Int J Environ Res Public Health. 2015;12:14461-76 pubmed publisher
    ..related to maternal smoking using this method, replicating findings in well-known smoking related genes MYO1G and GFI1. Further weak associations were found at the AHRR and CYP1A1 loci...
  29. Zeng H, Chi H. mTOR signaling and transcriptional regulation in T lymphocytes. Transcription. 2014;5:e28263 pubmed publisher
    ..This review discusses how mTOR signaling, through impinging upon transcriptional factors, regulates T cell development, activation, and effector and memory differentiation. ..
  30. Costa A, Powell L, Lowell S, Jarman A. Atoh1 in sensory hair cell development: constraints and cofactors. Semin Cell Dev Biol. 2017;65:60-68 pubmed publisher
    ..We particularly focus on the possible roles of Gfi1 and Pou4f3, drawing from studies in mouse, Drosophila and C. elegans.
  31. Tanaka R, Hirohama K, Ozawa J. Can muscle weakness and disability influence the relationship between pain catastrophizing and pain worsening in patients with knee osteoarthritis? A cross-sectional study. Braz J Phys Ther. 2018;: pubmed publisher
    ..The relationship between pain catastrophizing with pain worsening are mediated by muscle weakness and disability. ..
  32. Chen J, Weiss W. When deletions gain functions: commandeering epigenetic mechanisms. Cancer Cell. 2014;26:160-1 pubmed publisher
    ..In a recent publication in Nature, Northcott and colleagues identify a novel region of structural variation in medulloblastoma that leads to oncogenic activation of GFI1B and GFI1 by repositioning these genes next to super-enhancers.
  33. Perpiñá C, Giraldo O Meara M, Roncero M, Martínez Gómez M. Confirmatory factor analysis and psychometric properties of the Yale-Brown-Cornell Eating Disorders Scale Self-Report version (SR-YBC-EDS) in Spanish clinical and non-clinical samples. Eat Behav. 2015;17:6-9 pubmed publisher
    ..6%, respectively). Findings indicate that the SR-YBC-EDS is a reliable and valid instrument to identify symptoms and assess the severity of ED, and it can be used as a faster and less costly alternative to the YBC-EDS interview. ..
  34. Richmond R, Simpkin A, Woodward G, Gaunt T, Lyttleton O, McArdle W, et al. Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Hum Mol Genet. 2015;24:2201-17 pubmed publisher
    ..In cord blood, methylation at 15 CpG sites in seven gene regions (AHRR, MYO1G, GFI1, CYP1A1, CNTNAP2, KLF13 and ATP9A) was associated with maternal smoking, and a dose-dependent response was observed ..
  35. Schwender K, Holtkötter H, Johann K, Glaub A, Schürenkamp M, Sibbing U, et al. Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. Forensic Sci Med Pathol. 2016;12:399-406 pubmed
    ..DNA methylation state of a CpG island located upstream of the promoter of the growth factor independent 1 (GFI1) gene was analyzed...
  36. Lee B, Baek J, Min H, Bae S, Moon K, Kim M, et al. Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol. 2018;55:6518-6532 pubmed publisher
    ..Thus, we generated two different inner ear-specific Exoc5 knockout models by crossing Gfi1Cre mice with Exoc5f/f mice for hair cell-specific deletion (Gfi1Cre/+;Exoc5f/..
  37. Dwivedi P, Anderson P, Tilley W, May B, Morris H. Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells. J Steroid Biochem Mol Biol. 2007;103:742-6 pubmed
    ..Recently, we have identified a role for the transcription factor, Growth Factor Independent-1 (GFI1) in the repression of the CYP27B1 gene in human prostate cancer cell lines...
  38. Nakanishi Y, Reina Campos M, Nakanishi N, Llado V, Elmén L, Peterson S, et al. Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Cell Rep. 2016;16:3297-3310 pubmed publisher
    ..Here, we show that PKCλ/ι is required for Paneth cell differentiation at the level of Atoh1 and Gfi1, through the control of EZH2 stability by direct phosphorylation...
  39. Miyake K, Kawaguchi A, Miura R, Kobayashi S, Tran N, Kobayashi S, et al. Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. Sci Rep. 2018;8:5654 pubmed publisher
    ..secondary comparisons between St-S and Su-S revealed nine common sites that mapped to ACSM3, AHRR, CYP1A1, GFI1, SHANK2, TRIM36, and the intergenic region between ANKRD9 and RCOR1 in Ne-S vs...
  40. Liang L, Zeng J, Qin X, Chen J, Luo D, Chen G. Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data. Cell Physiol Biochem. 2018;48:475-490 pubmed publisher
    ..were related to overall survival in left-sided, and eight distinguishable genes (EREG, ERFE, HOXC6, SLC22A31, TFF1, GFI1, ZG16, RASL10B) in right-sided. Further, left-sided prognostic model was established with PHACTR3 and CKMT2 (HR=2...
  41. Califano D, Cho J, Uddin M, Lorentsen K, Yang Q, Bhandoola A, et al. Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells. Immunity. 2015;43:354-68 pubmed publisher
    ..considered a T-cell-specific transcription factor, acted directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature ILC2s...
  42. Sabater Galindo M, Ruiz de Maya S, Benrimoj S, Gastelurrutia M, Martinez Martinez F, Sabater Hernández D. Patients' expectations of the role of the community pharmacist: Development and testing of a conceptual model. Res Social Adm Pharm. 2017;13:313-320 pubmed publisher
    ..When the perceived image of the pharmacist is enhanced, patients' expectations of the pharmacist are heightened; in turn, these expectations were associated with reactions of patients. ..
  43. Desnues B, Macedo A, Ordoñez Rueda D, Roussel Queval A, Malissen B, Bruhns P, et al. The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling. Eur J Immunol. 2016;46:2801-2811 pubmed publisher
    The transcriptional repressor growth factor independence 1 (Gfi1) is important in myeloid and lymphoid differentiation. In the current study we evaluated the involvement of Gfi1 in systemic lupus erythematosus (SLE)...
  44. Sengupta S, Smith A, Grizenko N, Joober R. Locus-specific DNA methylation changes and phenotypic variability in children with attention-deficit hyperactivity disorder. Psychiatry Res. 2017;256:298-304 pubmed publisher
    ..Three genes (AHRR, CYP1A1, GFI1) were selected based on previous results observed in the general population...
  45. Petrusca D, Toscani D, Wang F, Park C, Crean C, Anderson J, et al. Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis. J Hematol Oncol. 2018;11:123 pubmed publisher
    ..We previously showed that MM cells upregulate the transcriptional repressor, growth factor independence 1 (Gfi1), in bone marrow stromal cells (BMSCs) that induces prolonged inhibition of osteoblast ..
  46. Sokhonevich N, Yurova K, Gutsol A, Khaziakhmatova O, Mazunin I, Litvinova L. Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi1 and U2afll4 Genes in T Cells at Different Stages of Differentiation. Bull Exp Biol Med. 2015;159:236-9 pubmed publisher
    Opposite effects of common γ-chain cytokines (IL-2, IL-7, and IL-15) on the expression of Gfi1 and U2af1l4 genes regulating alternative splicing of Ptprc gene in T cells at different stages of differentiation were demonstrated in vitro...
  47. Yasuoka T, Kuwahara M, Yamada T, Maruyama S, Suzuki J, Taniguchi M, et al. The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells. PLoS ONE. 2016;11:e0157395 pubmed publisher
    b>Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear...
  48. Küpers L, Xu X, Jankipersadsing S, Vaez A, La Bastide Van Gemert S, Scholtens S, et al. DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. Int J Epidemiol. 2015;44:1224-37 pubmed publisher
    ..birth cohorts, we replicated and meta-analysed results of eight cytosine-phosphate-guanine (CpG) sites in the GFI1 gene, which showed the most robust mediation. Finally, we performed functional network and enrichment analysis...
  49. Arun A, Senthamizhselvi A, Hemamalini S, Edison E, Korula A, Fouzia N, et al. Spectrum of ELANE mutations in congenital neutropenia: a single-centre study in patients of Indian origin. J Clin Pathol. 2018;71:1046-1050 pubmed publisher
    ..congenital neutropenia is genetically heterogeneous with mutations in genes like ELANE, HAX-1, G6PC3 and GFI1. The presence of ELANE mutation aids in the establishment of diagnosis and rules out other secondary ..
  50. Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018;9:1418 pubmed publisher
    b>GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia...
  51. Rotroff D, Joubert B, Marvel S, Håberg S, Wu M, Nilsen R, et al. Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero. BMC Genomics. 2016;17:976 pubmed
    ..25). Six of these 15 genes (GFI1, MYO1G, CYP1A1, RUNX1, LCTL, and AHRR) contained individual CpGs that were differentially methylated with regards ..
  52. Zhu L, Meng Q, Liang S, Ma Y, Li R, Li G, et al. The transcription factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages. FEBS Lett. 2014;588:4513-9 pubmed
    ..Previously, we had demonstrated that the zinc-finger protein GFI1 inhibits pro-IL-1β transcription...
  53. Al Matary Y, Botezatu L, Opalka B, Hönes J, Lams R, Thivakaran A, et al. Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner. Haematologica. 2016;101:1216-1227 pubmed
    ..We found that the transcriptional repressor Growth factor independence 1 is crucial in the process of macrophage polarization, since its absence impedes macrophage polarization ..
  54. Chatterjee R, Chattopadhyay S, Law S. Alteration of classical and hematopoiesis specific p53 pathway in the bone marrow hematopoietic stem/progenitor compartment facilitates leukemia progression in experimental mice. Leuk Res. 2016;47:70-7 pubmed publisher
    ..The study presents the mechanistic scenario of the alteration of both classical as well as hematopoiesis specific p53 pathways in HSPC compartment triggering leukemic pathophysiology. ..
  55. Sasaki T, Tanaka Y, Kulkeaw K, Yumine Takai A, Tan K, Nishinakamura R, et al. Embryonic Intra-Aortic Clusters Undergo Myeloid Differentiation Mediated by Mesonephros-Derived CSF1 in Mouse. Stem Cell Rev. 2016;12:530-542 pubmed
    ..Expression of Cebpa and Irf8 mRNAs was higher in CSF1R-positive IACs, whereas that of Cebpε and Gfi1 mRNAs was lower relative to CSF1R-negative IACs, suggesting that CSF1/CSF1R signaling functions in IAC myeloid ..
  56. Adamik J, Jin S, Sun Q, Zhang P, Weiss K, Anderson J, et al. EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation. Mol Cancer Res. 2017;15:405-417 pubmed publisher
    ..Previously, it was observed that multiple myeloma induces the transcription repressor GFI1 in osteoblast precursors, which correlates with decreased Runx2 expression, thus prompting detailed ..
  57. Zhao L, Ye P, Gonda T. The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1. Oncogene. 2014;33:4442-9 pubmed publisher
    ..Here we show that GFI1, which encodes an important regulator of hematopoietic stem cell (HSC) function and granulocytic differentiation, ..
  58. ANDRADE D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, et al. SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis. Mol Cell Biol. 2016;36:1438-50 pubmed publisher
    ..The transcriptional repressor growth factor independence 1 (GFI1) is comprised of conserved Snail/Slug/Gfi1 (SNAG) and zinc finger motifs separated by a linker ..
  59. Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, et al. Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia. Cancer Sci. 2016;107:890-8 pubmed publisher
    ..Inverse PCR identified eight retroviral common integration sites, in which enhanced expression was observed in the Gfi1, Mycn, and Pim1 genes...
  60. Olsson A, Venkatasubramanian M, Chaudhri V, Aronow B, Salomonis N, Singh H, et al. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature. 2016;537:698-702 pubmed publisher
    ..stem cell/progenitor gene expression programme, instead expressing low levels of the myeloid determinants, Irf8 and Gfi1 (refs 9, 10, 11, 12, 13)...
  61. Shi L, Saravia J, Zeng H, Kalupahana N, Guy C, Neale G, et al. Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes. Proc Natl Acad Sci U S A. 2017;114:E67-E74 pubmed publisher
    ..We report here that transcription repressor Growth factor independent 1 (Gfi1) orchestrates the fidelity of the DP gene expression program and developmental maturation into SP cells...
  62. Purizaca J, Contreras Quiroz A, Dorantes Acosta E, Vadillo E, Arriaga Pizano L, Fuentes Figueroa S, et al. Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and express high levels of the transcriptional repressor Gfi-1. Clin Dev Immunol. 2013;2013:349067 pubmed publisher
    ..Together, our findings reveal major functional defects in the primitive hematopoietic component of ALL BM. A possible contribution of high levels of Gfi-1 expression in the regulation of the stem/progenitor cell biology is suggested. ..
  63. Hönes J, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, et al. GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016;30:1237-45 pubmed publisher
    Genetic and epigenetic aberrations contribute to the initiation and progression of acute myeloid leukemia (AML). GFI1, a zinc-finger transcriptional repressor, exerts its function by recruiting histone deacetylases to target genes...
  64. Jiang X, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, et al. miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia. Nat Commun. 2016;7:11452 pubmed publisher
    ..The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss...
  65. Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, et al. Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1. PLoS ONE. 2016;11:e0160344 pubmed publisher
    ..fate in hematopoietic progenitors has been proposed, in which a network of the transcription factors Egr1/2, Nab, Gfi1 and PU.1 forms the core element...
  66. Mitchell B, Anderson M, Ferguson J. A predictive model of days from infection to discharge in patients with healthcare-associated urinary tract infections: a structural equation modelling approach. J Hosp Infect. 2017;97:282-287 pubmed publisher
  67. Volpe G, Walton D, Grainger D, Ward C, Cauchy P, Blakemore D, et al. Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature. Sci Rep. 2017;7:11148 pubmed publisher
    b>Growth Factor Independence 1 (GFI1) is a transcriptional repressor that plays a critical role during both myeloid and lymphoid haematopoietic lineage commitment...
  68. Lee J, Govindarajah V, Goddard B, Hinge A, Muench D, Filippi M, et al. Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression. J Exp Med. 2018;215:627-644 pubmed publisher
    ..we establish that the oxidative stress induced by obesity dysregulates the expression of the transcription factor Gfi1 and that increased Gfi1 expression is required for the abnormal HSC function induced by obesity...
  69. Maiques Diaz A, Spencer G, Lynch J, Ciceri F, Williams E, Amaral F, et al. Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia. Cell Rep. 2018;22:3641-3659 pubmed publisher
    ..Rather, LSD1 inhibitors disrupt the interaction of LSD1 and RCOR1 with the SNAG-domain transcription repressor GFI1, which is bound to a discrete set of enhancers located close to transcription factor genes that regulate myeloid ..
  70. Moignard V, Macaulay I, Swiers G, Buettner F, Schütte J, Calero Nieto F, et al. Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Nat Cell Biol. 2013;15:363-72 pubmed publisher
    ..negatively correlated transcription factor pairings, including previously unrecognized relationships between Gata2, Gfi1 and Gfi1b...
  71. Thambyrajah R, Mazan M, Patel R, Moignard V, Stefanska M, Marinopoulou E, et al. GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nat Cell Biol. 2016;18:21-32 pubmed publisher
    ..Here, we establish the absolute requirement of the transcriptional repressors GFI1 and GFI1B (growth factor independence 1 and 1B) in this unique trans-differentiation process...
  72. Furusawa J, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, et al. Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis. PLoS Pathog. 2016;12:e1005507 pubmed publisher
    ..These progenitors expressed myeloid transcription factors such as Spi1, Gfi1, and Cebpa/b through activation of signal transducer and activator of transcription 1 and 3, and had enhanced ..
  73. Thambyrajah R, Patel R, Mazan M, Lie A Ling M, Lilly A, Eliades A, et al. New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells. Cell Cycle. 2016;15:2108-2114 pubmed
    ..In this Extra Views report, we discuss our recent studies demonstrating that the transcriptional repressors GFI1 and GFI1B have a critical role in the EHT...
  74. Huang J, Zhou Q, Huang C, Song Y, Sharma A, Liao Z, et al. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017;292:4770-4776 pubmed publisher
    ..Furthermore, NE deletion prevents HFD-induced vascular leakage. Thus, HFD feeding rapidly activates bone marrow myelopoiesis through the NE-dependent C/EBPα-GFI-1 pathway preceding vascular damage and systemic inflammation. ..
  75. Chatterjee R, Gupta S, Law S. Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimental myelodysplasia. Chem Biol Interact. 2017;273:1-10 pubmed publisher
  76. Hwang C, Guo D, Harris M, Howard O, Mishina Y, Gan L, et al. Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice. Dev Dyn. 2010;239:505-13 pubmed publisher
    ..of Bmp2 for hair cell formation, we deleted Bmp2 in the cochlear hair cells using two cre strains, Foxg1(cre/+) and Gfi1(cre/+). Bmp2 conditional knockout cochleae generated using these two cre strains show normal hair cells...
  77. Costa A, Sánchez Guardado L, Juniat S, Gale J, Daudet N, Henrique D. Generation of sensory hair cells by genetic programming with a combination of transcription factors. Development. 2015;142:1948-59 pubmed publisher
    ..Here, we show that combined expression of the transcription factors Gfi1, Pou4f3 and Atoh1 can induce direct programming towards HC fate, both during in vitro mouse embryonic stem cell ..
  78. Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, et al. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells. Immunology. 2016;147:476-87 pubmed publisher
    A transcriptional repressor Gfi1 promotes T helper type 2 (Th2) cell development and inhibits Th17 and inducible regulatory T-cell differentiation...
  79. Zhang Y, Florath I, Saum K, Brenner H. Self-reported smoking, serum cotinine, and blood DNA methylation. Environ Res. 2016;146:395-403 pubmed publisher
    ..The strongest associations were observed for several loci at AHRR, F2RL3, 2q37.1, 6p21.33, and GFI1 that were previously identified to be related to self-reported smoking. One locus at RAB34 was newly discovered...
  80. Guo H, Cooper S, Friedman A. In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis. PLoS ONE. 2016;11:e0150809 pubmed publisher
    ..1 and Gfi1 and increased Egr1 and Klf4 in GMP...
  81. Botezatu L, Michel L, Helness A, Vadnais C, Makishima H, Hönes J, et al. Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML. Exp Hematol. 2016;44:713-726.e14 pubmed publisher
    ..A single-nucleotide polymorphism of transcription factor growth factor independence 1 (GFI1) generates a protein with an asparagine at position 36 (GFI1(36N)) instead of a serine at ..
  82. Huang X, Nandakumar V, Tumurkhuu G, Wang T, Jiang X, Hong B, et al. Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development. Cell Death Dis. 2016;7:e2260 pubmed publisher
  83. Du P, Tang F, Qiu Y, Dong F. GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis. PLoS ONE. 2013;8:e73542 pubmed publisher
    b>GFI1 is a transcriptional repressor that plays a critical role in hematopoiesis and has also been implicated in lymphomagenesis. It is still poorly understood how GFI1 expression is regulated in the hematopoietic system...
  84. Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, et al. Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. 2002;100:2769-77 pubmed
    ..These findings establish Gfi-1B as a novel erythroid regulator and reveal its specific involvement in the regulation of erythroid cell growth through modulating erythroid-specific gene expression. ..
  85. Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, et al. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017;24:929-943 pubmed publisher
    ..Here, we unveil a CRC-specific metastatic programme that is triggered via the transcriptional repressor, GFI1. Using data from a large cohort of clinical samples including inflammatory bowel disease and CRC, and a cellular ..
  86. Huang M, Hu Z, Chang W, Ou D, Zhou J, Zhang Y. The growth factor independence-1 (Gfi1) is overexpressed in chronic myelogenous leukemia. Acta Haematol. 2010;123:1-5 pubmed publisher
    ..In CML patients, we determined the expression of growth factor independence-1 (Gfi1), a transcription repressor with weak oncogenic activity...
  87. Khandanpour C, Moroy T. Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL. Oncotarget. 2013;4:374-5 pubmed
    The transcriptional repressor Gfi1 can be a so-called "oncorequisite" factor that is required for the development and maintenance of lymphoid neoplasia, such as Acute Lymphoblastic Leukemia (ALL), but does not have a direct role ..
  88. Möröy T, Vassen L, Wilkes B, Khandanpour C. From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation. Blood. 2015;126:2561-9 pubmed publisher
    The DNA-binding zinc finger transcription factors Gfi1 and Gfi1b were discovered more than 20 years ago and are recognized today as major regulators of both early hematopoiesis and hematopoietic stem cells...
  89. Botezatu L, Michel L, Makishima H, Schroeder T, Germing U, Haas R, et al. GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome. Exp Hematol. 2016;44:590-595.e1 pubmed publisher
    Inherited gene variants play an important role in malignant diseases. The transcriptional repressor growth factor independence 1 (GFI1) regulates hematopoietic stem cell (HSC) self-renewal and differentiation...
  90. Zamorina S, Litvinova L, Yurova K, Khaziakhmatova O, Timganova V, Bochkova M, et al. The role of human chorionic gonadotropin in regulation of naïve and memory T cells activity in vitro. Int Immunopharmacol. 2018;54:33-38 pubmed publisher
    ..In parallel, expression of U2af1l4, Gfi1, and hnRNPLL genes, which are Ptprc gene alternative splicing regulators was evaluated...
  91. Bell D, Taguchi T, Jenkins N, Gilbert D, Copeland N, Gilks C, et al. Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents. Cytogenet Cell Genet. 1995;70:263-7 pubmed
    The Gfi1 gene encodes a zinc finger protein which binds DNA and is involved in transcriptional regulation...
  92. Marteijn J, van der Meer L, van Emst L, de Witte T, Jansen J, van der Reijden B. Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes. Blood. 2007;109:100-8 pubmed
    b>Gfi1 is a transcriptional repressor essential during myeloid differentiation...