GFER

Summary

Gene Symbol: GFER
Description: growth factor, augmenter of liver regeneration
Alias: ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, FAD-linked sulfhydryl oxidase ALR, ERV1 homolog, erv1-like growth factor, hepatic regenerative stimulation substance, hepatopoietin protein
Species: human
Products:     GFER

Top Publications

  1. Francavilla A, Hagiya M, Porter K, Polimeno L, Ihara I, Starzl T. Augmenter of liver regeneration: its place in the universe of hepatic growth factors. Hepatology. 1994;20:747-57 pubmed
  2. Li Y, Wei K, Lu C, Li Y, Li M, Xing G, et al. Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription. Eur J Biochem. 2002;269:3888-93 pubmed
    Hepatopoietin (HPO) is a novel human hepatotrophic growth factor...
  3. Thirunavukkarasu C, Wang L, Harvey S, Watkins S, Chaillet J, Prelich J, et al. Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J Hepatol. 2008;48:578-88 pubmed publisher
    Augmenter of liver regeneration (ALR), a protein synthesized and stored in hepatocytes, is associated with mitochondria, and possesses sulfhydryl oxidase and cytochrome c reductase activities...
  4. Daithankar V, Farrell S, Thorpe C. Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space. Biochemistry. 2009;48:4828-37 pubmed publisher
    Augmenter of liver regeneration (ALR) is both a growth factor and a sulfhydryl oxidase that binds FAD in an unusual helix-rich domain containing a redox-active CxxC disulfide proximal to the flavin ring...
  5. Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, et al. The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet. 2009;84:594-604 pubmed publisher
    ..The role of the human Erv1 ortholog, GFER, in the DRS has been poorly explored...
  6. Cao Y, Fu Y, Yu M, Yue P, Ge C, Xu W, et al. Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress. Free Radic Biol Med. 2009;47:1057-66 pubmed publisher
    ..Overexpression of ALR significantly increased the mitochondrial membrane potential, inhibited cytochrome c release, and opposed the loss ..
  7. Polimeno L, Pesetti B, Lisowsky T, Iannone F, Resta L, Giorgio F, et al. Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Free Radic Res. 2009;43:865-75 pubmed publisher
    ..Disulphide bridges formation is catalysed by sulphydryl oxidase enzymes. The neuroprotective effect of ALR protein (Alrp), a sulphydryl oxidase enzyme, on H(2)O(2)-induced apoptosis in SH-SY5Y cells has been evaluated...
  8. Banci L, Bertini I, Calderone V, Cefaro C, Ciofi Baffoni S, Gallo A, et al. Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proc Natl Acad Sci U S A. 2011;108:4811-6 pubmed publisher
    ..reduced and regenerated to a functional state through the interaction with the flavin-dependent sulfhydryl oxidase ALR. Here we present the mechanistic basis of ALR-MIA40 interaction at atomic resolution by biochemical and structural ..
  9. Mordas A, Tokatlidis K. The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis. Acc Chem Res. 2015;48:2191-9 pubmed publisher
    ..The sulfhydryl oxidase Erv1 generates the disulfide pairs de novo using either molecular oxygen or, cytochrome c and other proteins as terminal ..

More Information

Publications142 found, 100 shown here

  1. Qi S, Guan H, Deng G, Yang T, Cheng X, Liu W, et al. Rapid, reliable, and sensitive detection of adenosine deaminase activity by UHPLC-Q-Orbitrap HRMS and its application to inhibitory activity evaluation of traditional Chinese medicines. J Pharm Biomed Anal. 2018;153:175-181 pubmed publisher
    ..1% formic acid:methanol?=?85:15, v/v) at a flow rate of 0.3?mL?min-1 on a Waters ACQUITY HSS T3 column (2.1?mm?×?100?mm, 1.8??m) following a simple precipitation of proteins...
  2. Mikołajczyk A, Złotkowska D. Subclinical Lipopolysaccharide from Salmonella Enteritidis Induces Dysregulation of Bioactive Substances from Selected Brain Sections and Glands of Neuroendocrine Axes. Toxins (Basel). 2019;11: pubmed publisher
    ..brain sections and endocrine glands of the hypothalamic-pituitary-adrenal (HPA), -thyroid (HPT), -ovarian (HPO) axes. The study was conducted on ten immature crossbred female pigs...
  3. Rout P, Kaushik R, Ramachandran N. Differential expression pattern of heat shock protein 70 gene in tissues and heat stress phenotypes in goats during peak heat stress period. Cell Stress Chaperones. 2016;21:645-51 pubmed publisher
    ..of RR and HR over the breeds in the population, individual animals were recognized as heat stress-susceptible (HSS) and heat stress-tolerant (HST)...
  4. Lei G, Min S, Shangquan G, Jingquan Y, Yiyuan Z. [Molecular cloning and tissue expression of the CCNG1 gene in sheep]. Yi Chuan. 2015;37:374-81 pubmed publisher
    ..PCR, we detected and analyzed the expressions of CCNG1 gene at mRNA levels in the hypothalamus-pituitary-ovary (HPO) axis in different stages of an estrous cycle in Duo Lang sheep (non-seasonal breeding) and Merino sheep (seasonal ..
  5. Kim T, Lim D, Baek K, Jang S, Park B, Mayakrishnan V. Production of chitinase from Escherichia fergusonii, chitosanase from Chryseobacterium indologenes, Comamonas koreensis and its application in N-acetylglucosamine production. Int J Biol Macromol. 2018;112:1115-1121 pubmed publisher
    ..flour, yeast extract, soybean flour, (NH4)2SO4, NH4Cl and K2HPO4 were found to be the potential activator for exo-chitosanase activity...
  6. Leth I, McDonald K. Media development for large scale Agrobacterium tumefaciens culture. Biotechnol Prog. 2017;33:1218-1225 pubmed publisher
    ..O), sodium chloride (NaCl), potassium chloride (KCl) and a sodium/potassium phosphate buffer (Na2 HPO4 /KH2 PO4 )...
  7. Zuo L, Sun Z, Wang Z, Du S, Kong X, Li L, et al. Pharmacokinetics and tissue distribution study of prucalopride in rats by ultra high performance liquid chromatography with tandem mass spectrometry. J Pharm Biomed Anal. 2016;131:246-255 pubmed publisher
    ..Chromatographic separation was performed on a Waters ACQUITY UPLC® HSS C18 column (2.1mm×50mm, 1.8?m) with a gradient mobile phase consisting of acetonitrile-water (containing 0...
  8. Pauk V, Pluháček T, Havlicek V, Lemr K. Ultra-high performance supercritical fluid chromatography-mass spectrometry procedure for analysis of monosaccharides from plant gum binders. Anal Chim Acta. 2017;989:112-120 pubmed publisher
    ..An Acquity HSS C18SB column outperformed other three tested stationary phases (BEH (silica), BEH 2-ethylpyridine, CSH Fluoro-..
  9. Tang C, Lin H, Wu Q, Zhang Y, Bie P, Yang J. Recombinant human augmenter of liver regeneration protects hepatocyte mitochondrial DNA in rats with obstructive jaundice. J Surg Res. 2015;196:90-101 pubmed publisher
    ..rhALR may protect and improve mitochondrial and hepatic functions in rats with OJ by promoting the expression of mtTFA and NRF-1 and by protecting and repairing damaged mtDNA. ..
  10. Jacquillet G, Unwin R. Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi). Pflugers Arch. 2019;471:83-98 pubmed publisher
    ..in plasma or serum Pi exists in both its monovalent and divalent forms (H2PO4- and HPO42-)...
  11. Hu Q, Jin J, Zhou H, Yu D, Qian W, Zhong Y, et al. Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons. Biomed Pharmacother. 2018;107:1363-1369 pubmed publisher
    ..of women in reproductive age, is typical with hyperandrogenism and disturbance of the hypothalamus-pituitary-ovary (HPO) axis, i.e...
  12. Southmayd E, De Souza M. A summary of the influence of exogenous estrogen administration across the lifespan on the GH/IGF-1 axis and implications for bone health. Growth Horm IGF Res. 2017;32:2-13 pubmed publisher
    ..by the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis and the hypothalamic-pituitary-ovarian (HPO) axis...
  13. Hawley K, Cruz A, Benjamin S, La Vake C, Cervantes J, Ledoyt M, et al. IFN? Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages. Front Immunol. 2017;8:1227 pubmed publisher
    ..Previously, we demonstrated that human syphilitic serum (HSS) promotes efficient uptake of Tp by human monocytes and that opsonophagocytosis of Tp markedly ..
  14. Czarnowska A, Kapica Topczewska K, Zajkowska O, Swierzbinska R, Chorazy M, Tarasiuk J, et al. Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study. Eur Neurol. 2018;80:229-235 pubmed publisher
    ..Viral aetiology has been suspected to be an MS trigger for a long time, and herpesviruses (HSs) are among the potential pathogens involved...
  15. Herrera B, Hasturk H, Kantarci A, Freire M, Nguyen O, Kansal S, et al. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infect Immun. 2015;83:792-801 pubmed publisher
    ..engineered mice, including T2D mice (db/db), transgenic mice overexpressing the human resolvin E1 (RvE1) receptor (ERV1), and a newly bred strain of db/ERV1 mice, were used to determine the impact of RvE1 on the phagocytosis of ..
  16. Zhou B, Leng Y, Lei S, Xia Z. AMPK activation restores ischemic post‑conditioning cardioprotection in STZ‑induced type 1 diabetic rats: Role of autophagy. Mol Med Rep. 2017;16:3648-3656 pubmed publisher
    ..and/or 3‑MA, and subjected to hypoxia reoxygenation (HR) or hypoxia post‑conditioning (HPO)...
  17. Gilbert M, Bährs H, Steinberg C, Wilhelm C. The artificial humic substance HS1500 does not inhibit photosynthesis of the green alga Desmodesmus armatus in vivo but interacts with the photosynthetic apparatus of isolated spinach thylakoids in vitro. Photosynth Res. 2018;137:403-420 pubmed publisher
    Humic substances (HSs) can influence the growth and composition of freshwater phytoplankton assemblage...
  18. Proietto S, Yankelevich L, Villarreal F, Inserra P, Charif S, Schmidt A, et al. Pituitary estrogen receptor alpha is involved in luteinizing hormone pulsatility at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha). Gen Comp Endocrinol. 2019;273:40-51 pubmed publisher
    ..We have described the activation of the hypothalamic - pituitary - ovarian (HPO) axis during pregnancy...
  19. Jia Y, Liu X, Jia Q, Zhang W, Sun C, Yuan D, et al. The anti-hyperplasia of mammary gland effect of protein extract HSS from Tegillarca granosa. Biomed Pharmacother. 2017;85:1-6 pubmed publisher
    ..granosa. In this study, we investigated the anti-HMG effect of protein extract named HSS from T. granosa...
  20. Adas G, Koc B, Adas M, Duruksu G, Subasi C, Kemik O, et al. Effects of mesenchymal stem cells and VEGF on liver regeneration following major resection. Langenbecks Arch Surg. 2016;401:725-40 pubmed publisher
    ..EGF), transforming growth factor (TGF), hepatocyte growth factor (HGF), and augmenter of liver regeneration (ALR) were analyzed in the remnant liver tissue...
  21. Nakaya Y, Lilue J, Stavrou S, Moran E, Ross S. AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA. MBio. 2017;8: pubmed publisher
    ..Here we show that the mouse ALR IFI205 senses cytosolic retrotransposon DNA independently of cyclic GMP-AMP production...
  22. Huang H, Yang Y, Lv C, Chang W, Peng C, Wang S, et al. Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin Pill following oral administration to mice. J Ethnopharmacol. 2015;161:175-85 pubmed publisher
    ..by liquid-liquid extraction with ethyl acetate, and the separation of bufadienolides was achieved using an ACQUITY HSS T3 column by gradient elution using water (containing 0...
  23. Roy C, Tremblay P, Bienvenu J, Ayotte P. Quantitative analysis of amino acids and acylcarnitines combined with untargeted metabolomics using ultra-high performance liquid chromatography and quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1027:40-9 pubmed publisher
    ..Separation of metabolites is performed by ion-pair reverse phase UHPLC using a HSS T3 column (2.1×100mm, 100Å, 1...
  24. Dambuza N, Smith P, Evans A, Norman J, Taylor D, Andayi A, et al. Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model. Malar J. 2015;14:505 pubmed publisher
    ..3-Hydroxylpyridin-4-ones are known to chelate iron; hydroxypyridone-chloroquine (HPO-CQ) hybrids were synthesized in order to determine whether they can inhibit parasites proliferation in the ..
  25. Liu D, Li Y, Cai G, Jia D, Mao J, Meng X, et al. [Short-term effectiveness of total knee arthroplasty assisted by three-dimensional printing osteotomy navigation template]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32:899-905 pubmed publisher
    ..time, the pre- and post-operative hemoglobin values, the amount of drainage, the Hospital for Special Surgery (HSS) score and Knee Society Score (KSS) of knee joint before operation and at 3 months after operation were observed...
  26. Pfannebecker J, Schiffer Hetz C, Fröhlich J, Becker B. Culture medium optimization for osmotolerant yeasts by use of a parallel fermenter system and rapid microbiological testing. J Microbiol Methods. 2016;130:14-22 pubmed publisher
    ..1-0.2% ammonium salts ((NH4)2HPO4, (NH4)2SO4 or NH4NO3), 0...
  27. Sak Ubol S, Namvijitr P, Pechsrichuang P, Haltrich D, Nguyen T, Mathiesen G, et al. Secretory production of a beta-mannanase and a chitosanase using a Lactobacillus plantarum expression system. Microb Cell Fact. 2016;15:81 pubmed publisher
    ..antibiotics, the erythromycin resistance gene was replaced on the expression plasmid with the alanine racemase (alr) gene, which led to comparable levels of protein production and secretion efficiency in a suitable, alr-deficient L...
  28. Zhou W, Tam K, Meng M, Shan J, Wang S, Ju W, et al. Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration of traditional Chinese medicine Flos Lonicerae Japonicae-Fructus Forsythiae herb couple by sequential negative and positive ionization ultra-high-per. J Chromatogr A. 2015;1376:84-97 pubmed publisher
    ..7μm) with acetonitrile/methanol (4:1, v/v)-water as mobile phase. For analyzing quinic acid, an ACQUITY UPLC HSS T3 column (100mm×2.1mm, 1.8μm) was applied with acetonitrile/methanol (4:1, v/v)-0...
  29. Cui Z, Liao J, Cheong N, Longoria C, Cao G, DeLisser H, et al. The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury. Matrix Biol. 2018;: pubmed publisher
    ..M1 macrophage content, as well as decreased fibrosis as determined by trichrome staining, Ashcroft scores and lung HPO content...
  30. Gailite I, Aerne B, Tapon N. Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system. Proc Natl Acad Sci U S A. 2015;112:E5169-78 pubmed publisher
    The Hippo (Hpo) pathway is a highly conserved tumor suppressor network that restricts developmental tissue growth and regulates stem cell proliferation and differentiation...
  31. Zhang P, Lian K, Luo D, Huang Z, Li T, Lin D. A combined approach for the treatment of lateral and posterolateral tibial plateau fractures. Injury. 2016;47:2326-2330 pubmed publisher
    ..Operation time, intraoperative blood loss, fracture healing time, Hospital for Special Surgery (HSS) knee score, knee flexion and extension range of motion, and complications were recorded to evaluate treatment ..
  32. Shen G, Zhang H, Long D, Li Z, Tan Y. [Intramedullary nailing combined with cannulated screw in treating femoral condyles fractures]. Zhongguo Gu Shang. 2017;30:656-659 pubmed publisher
    ..There were no cases of loosening, breakage of internal fixators and re-fracture. Hospital for Special Surgery(HSS) knee score was 90.07±4.99 at 1 year after the operation...
  33. Zhang Y, Zhou J, Zhao J, Peng J, Liu X, Liu X, et al. Expression, purification and bioactivity of human augmenter of liver regeneration. World J Gastroenterol. 2006;12:4401-5 pubmed
    ..01). Purified hALR has the ability to stimulate DNA synthesis of adult rat hepatocytes in primary culture and HepG2 cells in vitro, and can provide evidence for its clinical application. ..
  34. Longo U, Ciuffreda M, D Andrea V, Mannering N, Locher J, Denaro V. All-polyethylene versus metal-backed tibial component in total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2017;25:3620-3636 pubmed publisher
    ..3 (n.s.), the mean KSS(F) was 73.6 and 74.9 (p = 0.04), the mean ROM was 104.5 and 104.6 (n.s.), and the mean HSS was 87 and 86, each, respectively, for the metal-backed tibial components group and all-polyethylene tibial ..
  35. Kohler S, Vasilevsky N, Engelstad M, Foster E, McMurry J, Ayme S, et al. The Human Phenotype Ontology in 2017. Nucleic Acids Res. 2017;45:D865-D876 pubmed publisher
    ..The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology...
  36. Kang Y, Kim Y, Kang J, Yun W, Kim A. Erythroid specific activator GATA-1-dependent interactions between CTCF sites around the ?-globin locus. Biochim Biophys Acta Gene Regul Mech. 2017;1860:416-426 pubmed publisher
    ..Furthermore Rad21 occupancy was reduced in the ?-globin locus control region (LCR) hypersensitive sites (HSs) by the depletion of GATA-1 or KLF1...
  37. Różkowski J, Różkowski K, Rahmonov O, Rubin H. Nitrates and phosphates in cave waters of Kraków-Częstochowa Upland, southern Poland. Environ Sci Pollut Res Int. 2017;24:25870-25880 pubmed publisher
    ..Among phosphorus speciations, dissolved forms are dominant: HPO42-, H2PO4-, and the insoluble form CaHPO4; in ..
  38. Li H, Zheng X, Liu Y, Zhang Z, Jiang T. Ultrafast interfacial energy transfer and interlayer excitons in the monolayer WS2/CsPbBr3 quantum dot heterostructure. Nanoscale. 2018;10:1650-1659 pubmed publisher
    ..is rarely observed, CsPbBr3 quantum dots (0D-QDs) interfaced with 2D materials have become attractive HSs for exploring the physics of charge transfer and energy transfer, due to their superior optical properties...
  39. Sanz Ruiz P, Carbó Laso E, Alonso Polo B, Matas Diez J, Vaquero Martín J. Does a new implant design with more physiological kinematics provide better results after knee arthroplasty?. Knee. 2016;23:399-405 pubmed publisher
    ..The functional and radiographic results were interpreted with the Hospital for Special Surgery (HSS) knee score and WOMAC score. After a mean follow-up of 84...
  40. Prasad Uday U, Bandyopadhyay T, Goswami S, Bhunia B. Optimization of physical and morphological regime for improved cellulase free xylanase production by fed batch fermentation using Aspergillus niger (KP874102.1) and its application in bio-bleaching. Bioengineered. 2017;8:137-146 pubmed publisher
    ..5 g/L in the production medium. However, 3 g/L of xylan with 50 mM K2HPO4 having pH-7 was consecutively fed at 72 and 120 h of fermentation...
  41. Bidny S, Gago K, Chung P, Albertyn D, Pasin D. Simultaneous Screening and Quantification of Basic, Neutral and Acidic Drugs in Blood Using UPLC-QTOF-MS. J Anal Toxicol. 2017;41:181-195 pubmed publisher
    ..Separation of the analytes was achieved by gradient elution using Waters ACQUITY HSS C18 column (2.1 mm x 150 mm, 1.8 μm)...
  42. Weng J, Li W, Jia X, An W. Alleviation of Ischemia-Reperfusion Injury in Liver Steatosis by Augmenter of Liver Regeneration Is Attributed to Antioxidation and Preservation of Mitochondria. Transplantation. 2017;101:2340-2348 pubmed publisher
    ..In this study, the effects of augmenter of liver regeneration (ALR) on hepatic IRI in steatotic mice were investigated...
  43. Notaro M, Schubach M, Robinson P, Valentini G. Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods. BMC Bioinformatics. 2017;18:449 pubmed publisher
    ..In this context the Human Phenotype Ontology (HPO) provides a standard categorization of the abnormalities associated with human diseases...
  44. Cheng L, Jiang Y, Ju H, Sun J, Peng J, Zhou M, et al. InfAcrOnt: calculating cross-ontology term similarities using information flow by a random walk. BMC Genomics. 2018;19:919 pubmed publisher
    ..over 300 ontologies have been built including extensively used Disease Ontology (DO) and Human Phenotype Ontology (HPO)...
  45. Liu D, Zhang L, Xue W, Wang Y, Ju J, Zhao B. Knockout of the alanine racemase gene in Aeromonas hydrophila HBNUAh01 results in cell wall damage and enhanced membrane permeability. FEMS Microbiol Lett. 2015;362:fnv089 pubmed publisher
    This study focused on the alanine racemase gene (alr-2), which is involved in the synthesis of d-alanine that forms the backbone of the cell wall. A stable alr-2 knockout mutant of Aeromonas hydrophila HBNUAh01 was constructed...
  46. Lemasson E, Bertin S, Hennig P, Boiteux H, Lesellier E, West C. Development of an achiral supercritical fluid chromatography method with ultraviolet absorbance and mass spectrometric detection for impurity profiling of drug candidates. Part II. Selection of an orthogonal set of stationary phases. J Chromatogr A. 2015;1408:227-35 pubmed publisher
    ..Two high-performance columns were thus selected: ACQUITY UPC(2) HSS C18 SB and Nucleoshell HILIC.
  47. Jiang B, Li S, Liu W, Yang Y, Chen W, He D, et al. Inhibitive activities detection of monoamine oxidases (MAO) A and B inhibitors in human liver MAO incubations by UPLC-ESI-MS/MS. J Pharm Biomed Anal. 2015;115:283-91 pubmed publisher
    ..0→91.0) via isocratic elution (0.1% fromic acid:acetonitrile=60:40) on a HSS T3 column following a simple precipitation of proteins for sample treatment...
  48. Vaitekūnas J, Gasparavičiūtė R, Rutkienė R, Tauraitė D, Meškys R. A 2-Hydroxypyridine Catabolism Pathway in Rhodococcus rhodochrous Strain PY11. Appl Environ Microbiol. 2016;82:1264-1273 pubmed publisher
    ..By investigating a gene cluster (hpo) from this bacterium, we were able to reconstruct the catabolic pathway of 2-hydroxypyridine degradation...
  49. Qiu H, Geng J, Ren H, Ding L, Xu K, Zhang Y. Aquatic transformation of phosphite under natural sunlight and simulated irradiation. Water Res. 2017;109:69-76 pubmed publisher
    The phototransformation of phosphite (HPO32-, H2PO3-, +3) from Lake Taihu water (THW) under natural sunlight was evaluated...
  50. Zhou B, Lei S, Xue R, Leng Y, Xia Z, Xia Z. DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy. Clin Sci (Lond). 2017;131:1161-1178 pubmed publisher
    ..Combining HPO (hypoxic post-conditioning) with DJ-1 overexpression markedly attenuated HR (hypoxia-reoxygenation) injury in H9c2 ..
  51. Gao Y, Ren X, Tan X, Hayat T, Alsaedi A, Chen C. Insights into key factors controlling GO stability in natural surface waters. J Hazard Mater. 2017;335:56-65 pubmed publisher
    ..Mg2+, Ca2+ and Al3+), and anions (Cl-, HCO3-, HPO42- and SO42-) on graphene oxide (GO) stability were investigated to ..
  52. Czerwonko M, Huespe P, Elizondo C, Pekolj J, Gadano A, Barcan L, et al. Risk factors and outcomes of pyogenic liver abscess in adult liver recipients: a matched case-control study. HPB (Oxford). 2018;20:583-590 pubmed publisher
    Adult liver recipients (ALR) differ from the general population with pyogenic liver abscess (PLA) as they exhibit: reconstructed biliary anatomy, recurrent hospitalizations, poor clinical condition and are subjected to immunosuppression...
  53. Li Y, Zhang Z, Liu X, Li A, Hou Z, Wang Y, et al. A novel approach to the simultaneous extraction and non-targeted analysis of the small molecules metabolome and lipidome using 96-well solid phase extraction plates with column-switching technology. J Chromatogr A. 2015;1409:277-81 pubmed publisher
    ..investigated the columns and analytical conditions for small molecules metabolome and lipidome, separated by an HSS T3 and BEH C18 columns, respectively...
  54. Zhang Y, Wang H, Zhang J, Hu Y, Zhang L, Wu X, et al. The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. Biochim Biophys Acta. 2016;1861:310-9 pubmed publisher
    ..Here, we show that RNAi inactivation of predicted cytochrome b5 reductases hpo-19 and T05H4...
  55. Greene D, Richardson S, Turro E. Phenotype Similarity Regression for Identifying the Genetic Determinants of Rare Diseases. Am J Hum Genet. 2016;98:490-499 pubmed publisher
    ..The Human Phenotype Ontology (HPO) allows composite phenotypes to be represented systematically but association methods accounting for the ..
  56. Wang R, Kuang M, Nie H, Bai W, Sun L, Wang F, et al. Impact of Food Restriction on the Expression of the Adiponectin System and Genes in the Hypothalamic-Pituitary-Ovarian Axis of Pre-Pubertal Ewes. Reprod Domest Anim. 2016;51:657-64 pubmed publisher
    ..to investigate the expression of adiponectin system and patterns of genes in the hypothalamic-pituitary-ovary (HPO) axis of food-restricted pre-pubertal ewes...
  57. Joshi R, Mehendale S. Can we replace HIV sentinel surveillance platform with prevention of parent-to-child transmission (PPTCT) program data to assess HIV burden and trends in India?. Trans R Soc Trop Med Hyg. 2016;110:393-9 pubmed publisher
    Estimates of HIV burden in India are based on HIV sentinel surveillance (HSS), which has limitations such as insufficient sample size for district level analysis and ethical concerns...
  58. Petegrosso R, Park S, Hwang T, Kuang R. Transfer learning across ontologies for phenome-genome association prediction. Bioinformatics. 2017;33:529-536 pubmed publisher
    ..associations with the entire phenotype paths in predicting phenotype-gene associations in Human Phenotype Ontology (HPO)...
  59. Lee Y, Yu K, Kim Y, Yoon Y, Xie Z, Song E, et al. Kinetics and chemistry of hydrolysis of ultrathin, thermally grown layers of silicon oxide as biofluid barriers in flexible electronic systems. ACS Appl Mater Interfaces. 2017;: pubmed publisher
  60. Cho W, Kim J, Kim W, Kim D, Kim N, Bin S. Mobile-bearing unicompartmental knee arthroplasty in old-aged patients demonstrates superior short-term clinical outcomes to open-wedge high tibial osteotomy in middle-aged patients with advanced isolated medial osteoarthritis. Int Orthop. 2018;42:2357-2363 pubmed publisher
    ..The minimum follow-up was two years. Clinical outcomes were evaluated using the Hospital for Special Surgery (HSS) score, knee score (KS), and function score (FS) of the Knee Society Knee Scoring System...
  61. El Fallah R, Rouillon R, Vouvé F. Spectral characterization of the fluorescent components present in humic substances, fulvic acid and humic acid mixed with pure benzo(a)pyrene solution. Spectrochim Acta A Mol Biomol Spectrosc. 2018;199:71-79 pubmed publisher
    ..After extraction of humic substances (HSs), and their fractionation into fluvic acid (FA) and humic acid (HA), two fluorescent compounds (C1 and C<..
  62. Weinstein A. A mathematical model of the outer medullary collecting duct of the rat. Am J Physiol Renal Physiol. 2000;279:F24-45 pubmed
    ..With respect to the OMCD in situ, available buffer is predicted to be abundant, including delivered HCO(3)(-) and HPO(4)(2-), as well as peritubular NH(3)...
  63. Williams A, Lee G, Spilianakis C, Hwang S, Eisenbarth S, Flavell R. Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci U S A. 2013;110:6955-60 pubmed publisher
    ..The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR...
  64. Deligeoroglou E, Creatsas G. Dysfunctional uterine bleeding as an early sign of polycystic ovary syndrome during adolescence. Minerva Ginecol. 2015;67:375-81 pubmed
    ..Hypothalamic-pituitary-ovarian (HPO) axis immaturity right after menarche, is usually the most plausible cause...
  65. Bindal S, Gupta R. Hyperproduction of ?-glutamyl transpeptidase from Bacillus licheniformis ER15 in the presence of high salt concentration. Prep Biochem Biotechnol. 2017;47:163-172 pubmed publisher
    ..Medium consisting of Na2HPO4: 0.32% (w/v); KH2PO4: 0.15% (w/v); starch: 0.1% (w/v); soybean meal: 0...
  66. Trujillano D, Bertoli Avella A, Kumar Kandaswamy K, Weiss M, Köster J, Marais A, et al. Clinical exome sequencing: results from 2819 samples reflecting 1000 families. Eur J Hum Genet. 2017;25:176-182 pubmed publisher
    ..Clinical information given by the requesting physicians was translated to HPO terms. WES processes were performed according to standardized settings...
  67. Erdle B, Izadpanah K, Jaeger M, Jensen P, Konstantinidis L, Zwingmann J, et al. Comparative analysis of locking plate versus hook plate osteosynthesis of Neer type IIB lateral clavicle fractures. Arch Orthop Trauma Surg. 2017;137:651-662 pubmed publisher
    ..and radiological results and complications of locking plate osteosynthesis (LPO) versus hook plate osteosynthesis (HPO) with acromioclavicular joint (ACJ) stabilization...
  68. Haindrich A, Boudová M, Vancova M, Diaz P, Horakova E, Lukes J. The intermembrane space protein Erv1 of Trypanosoma brucei is essential for mitochondrial Fe-S cluster assembly and operates alone. Mol Biochem Parasitol. 2017;214:47-51 pubmed publisher
    Sulfhydryl oxidase Erv1 is a ubiquitous and conserved protein of the mitochondrial intermembrane space that plays a role in the transport of small sulfur-containing proteins...
  69. Jung S, Byun J, Oh S, Kim T, Park J, Rho G, et al. Multivalent ion-based in situ gelling polysaccharide hydrogel as an injectable bone graft. Carbohydr Polym. 2018;180:216-225 pubmed publisher
    ..HA) hydrogels with a controllable gelation rate using CaSO4 as a crosslinking agent and Na2HPO4 as a crosslinking retardation agent...
  70. Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, et al. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. FEBS Lett. 2003;540:86-90 pubmed
    ..system was used to obtain two BNIPL-interacting proteins, MIF (macrophage migration inhibitory factor) and GFER (growth factor erv1 (Saccharomyces cerevisiae)-like)...
  71. Choquet R, Maaroufi M, Fonjallaz Y, de Carrara A, Vandenbussche P, Dhombres F, et al. LORD: a phenotype-genotype semantically integrated biomedical data tool to support rare disease diagnosis coding in health information systems. AMIA Annu Symp Proc. 2015;2015:434-40 pubmed
    ..is the lack of consolidation of such information scattered in different thesaurus such as Orphanet, OMIM or HPO. The Linking Open data for Rare Diseases (LORD) web portal we developed stands as the first attempt to fill this ..
  72. Zaouter C, Taddei R, Wehbe M, Arbeid E, Cyr S, Giunta F, et al. A novel system for automated propofol sedation: hybrid sedation system (HSS). J Clin Monit Comput. 2017;31:309-317 pubmed publisher
    ..delivery of propofol for sedation integrating a decision support system, called the hybrid sedation system (HSS). The objective of this study is to compare this system with standard practice...
  73. Felicia Katherine R, Muthukumaran C, Sharmila G, Manoj Kumar N, Tamilarasan K, Jaiganesh R. Xanthan gum production using jackfruit-seed-powder-based medium: optimization and characterization. 3 Biotech. 2017;7:248 pubmed publisher
    ..to evaluate the linear and interaction effects of five medium variables (JSP, peptone, citric acid, K2HPO4 and KH2PO4) for XG production. Maximum XG production (51...
  74. Fan Y, Lu Y, Yu B, Tan C, Cui B. Extraction and purification of capsaicin from capsicum oleoresin using an aqueous two-phase system combined with chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1063:11-17 pubmed publisher
    ..5% was obtained using the optimal extraction system, which consisted of 16.3% UCON 50-HB-5100/10% K2HPO4/1% ethanol, a buffer pH of 4.35 and 0.24g of capsicum oleoresin...
  75. Rosas Hernández H, Cuevas E, Escudero Lourdes C, Lantz S, Sturdivant N, Imam S, et al. Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier. Neurosci Lett. 2018;672:123-129 pubmed publisher
    ..In the present study, we evaluated the effects of uniaxial high-speed stretch (HSS) at 0, 5, 10 and 15% on a pure culture of primary rat brain endothelial cells as an in vitro model of TBI to the ..
  76. Zhang L, Minegishi T, Nakabayashi M, Suzuki Y, Seki K, Shibata N, et al. Durable hydrogen evolution from water driven by sunlight using (Ag,Cu)GaSe2 photocathodes modified with CdS and CuGa3Se5. Chem Sci. 2015;6:894-901 pubmed publisher
    ..0 mA cm-2) under simulated sunlight irradiation in 0.1 M Na2HPO4 (pH 10)...
  77. Bergschmidt P, Ellenrieder M, Bader R, Kluess D, Finze S, Schwemmer B, et al. Prospective comparative clinical study of ceramic and metallic femoral components for total knee arthroplasty over a five-year follow-up period. Knee. 2016;23:871-6 pubmed publisher
    ..radiological evaluations were performed preoperatively and at three, 12, 24 and 60months postoperatively, using the HSS-, WOMAC- and SF36-Scores, in addition to standardized X-rays. The HSS-Score improved significantly from 58.7±12...
  78. Wohlfarth A, Vikingsson S, Roman M, Andersson M, Kugelberg F, Green H, et al. Looking at flubromazolam metabolism from four different angles: Metabolite profiling in human liver microsomes, human hepatocytes, mice and authentic human urine samples with liquid chromatography high-resolution mass spectrometry. Forensic Sci Int. 2017;274:55-63 pubmed publisher
    ..human case specimens, were analyzed (with or without hydrolysis, in case it was urine) by UHPLC-HRMS on an Acquity HSS T3 column with an Agilent 6550 QTOF...
  79. Hamid A, Musa S. The mediating effects of coping strategies on the relationship between secondary traumatic stress and burnout in professional caregivers in the UAE. J Ment Health. 2017;26:28-35 pubmed publisher
    ..ProQOL), The General Health Questionnaire (GHQ-28), The Maslach Burnout Inventory: Human Services Survey (MBI-HSS) and Endler and Parker's Coping Inventory...
  80. Tassoni R, van der Aart L, Ubbink M, van Wezel G, Pannu N. Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2). Biochem Biophys Res Commun. 2017;483:122-128 pubmed publisher
    ..The Gram-positive bacterium Streptomyces coelicolor has at least one alanine racemase encoded by alr. Here, we describe an alr deletion mutant of S...
  81. Soo V, Yosaatmadja Y, Squire C, Patrick W. Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J Biol Chem. 2016;291:19873-87 pubmed publisher
    ..In this study, we show that a representative of fold type III, the Escherichia coli alanine racemase (ALR), is a promiscuous cystathionine ?-lyase (CBL). Furthermore, E...
  82. Villar R, Hughson R. Vascular conductance and muscle blood flow during exercise are altered by inspired oxygen fraction and arterial perfusion pressure. Physiol Rep. 2017;5: pubmed publisher
    ..volunteers repeated plantar flexion contractions at 20% (low power output = LPO) and 30% (higher power output = HPO) of their maximal voluntary contraction in horizontal (HOR), 35° head-down-tilt (HDT) and 45° head-up-tilt (HUT)...
  83. Harding J, Osmond M, Krebs M. * Engineering Osteoinductive Biomaterials by Bioinspired Synthesis of Apatite Coatings on Collagen Hydrogels with Varied Pore Microarchitectures. Tissue Eng Part A. 2017;23:1452-1465 pubmed publisher
    ..scaffolds are mineralized with dicalcium phosphate dihydrate (DCPD) by alternate immersion in Ca2+ and HPO42- salt solutions...
  84. Liu N, Ding F, Weng C, Hwang C, Lin Y. Effective degradation of primary color direct azo dyes using Fe0 aggregates-activated persulfate process. J Environ Manage. 2018;206:565-576 pubmed publisher
    ..in systems containing salts Na2SO4, NaCl, Na2CO3, and Na2HPO4 at 1 × 10-2 M. The effect was suppressed when reaction temperature was raised to 55 °C...
  85. Zhou H, Lian L, Yan S, Song W. Insights into the photo-induced formation of reactive intermediates from effluent organic matter: The role of chemical constituents. Water Res. 2017;112:120-128 pubmed publisher
    ..EfOM was separated into hydrophobic (HPO), transphilic (TPI), and hydrophilic (HPI) components...
  86. Raj I, Vaidya A, Pandey R, Bansiwal A, Deshmukh S, Purohit H. Recent advancements in the mitigation of obnoxious nitrogenous gases. J Environ Manage. 2018;205:319-336 pubmed publisher
    ..and membrane bioreactors with innovative reactor design, mixing pattern, and air sparging, for example FEBR, ALR, etc...
  87. Sacks E, Swanson R, Schensul J, Gleave A, Shelley K, Were M, et al. Community Involvement in Health Systems Strengthening to Improve Global Health Outcomes: A Review of Guidelines and Potential Roles. Int Q Community Health Educ. 2017;37:139-149 pubmed publisher
    Definitions of health systems strengthening (HSS) have been limited in their inclusion of communities, despite evidence that community involvement improves program effectiveness for many health interventions...
  88. Muller C, Massier S, Le Breton Y, Rincé A. The role of the CroR response regulator in resistance of Enterococcus faecalis to D-cycloserine is defined using an inducible receiver domain. Mol Microbiol. 2017;: pubmed publisher
    ..Further, this work identified alr, the gene encoding the alanine racemase enzyme involved in E...
  89. Famurewa A, Nwankwo O, Folawiyo A, Igwe E, Epete M, Ufebe O. Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation. Acta Sci Pol Technol Aliment. 2017;16:451-460 pubmed publisher
    ..We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO).
  90. Awolusi O, Nasr M, Kumari S, Bux F. Artificial Intelligence for the Evaluation of Operational Parameters Influencing Nitrification and Nitrifiers in an Activated Sludge Process. Microb Ecol. 2016;72:49-63 pubmed publisher
    ..726, p 0.002), hydraulic retention time (HRT) (r -0.651, p 0.009), and ammonia loading rate (ALR) (r 0.571, p 0.026). Additionally, AOB was considerably influenced by HRT (r -0.741, p 0.002) and temperature (r 0...
  91. El Sayed S, Metwally K, El Shanawani A, Abdel Aziz L, El Rashedy A, Soliman M, et al. Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study. Bioorg Med Chem Lett. 2017;27:4760-4764 pubmed publisher
    ..Insertion of a methoxy group on the central benzylidene ring was found to have a variable effect on ALR-2 activity depending on the nature of peripheral quinazolinone ring substituents...
  92. Alexandrino H, Rolo A, Teodoro J, Donato H, Martins R, Serôdio M, et al. Bioenergetic adaptations of the human liver in the ALPPS procedure - how liver regeneration correlates with mitochondrial energy status. HPB (Oxford). 2017;19:1091-1103 pubmed publisher
    ..01). An increased expression of genes associated with liver regeneration (STAT3, ALR) and energy metabolism (PGC-1?, COX, Nampt) was found in T2 (p < 0.05)...