GFER

Summary

Gene Symbol: GFER
Description: growth factor, augmenter of liver regeneration
Alias: ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, ERV1 homolog, FAD-linked sulfhydryl oxidase ALR, erv1-like growth factor, hepatic regenerative stimulation substance, hepatopoietin protein
Species: human

Top Publications

  1. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
  2. ncbi Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase
    Tadao Oikawa
    Department of Biotechnology, Faculty of Engineering, Kansai University, 3 3 35 Yamate cho, Suita, Osaka Fu 564 8680, Japan
    J Biotechnol 125:503-12. 2006
  3. pmc Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes
    Chinnasamy Thirunavukkarasu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1542 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:578-88. 2008
  4. doi Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Free Radic Biol Med 47:1057-66. 2009
  5. doi Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    Lorenzo Polimeno
    Section of Gastroenterology, Department of Emergency and Organ Transplantation DETO, University of Bari, Bari, Italy
    Free Radic Res 43:865-75. 2009
  6. ncbi Augmenter of liver regeneration: its place in the universe of hepatic growth factors
    A Francavilla
    Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213
    Hepatology 20:747-57. 1994
  7. ncbi Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription
    Yong Li
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center, China
    Eur J Biochem 269:3888-93. 2002
  8. ncbi Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway
    Chengrong Lu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing 100850, P R China
    FASEB J 16:90-2. 2002
  9. pmc A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
    T G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:12068-73. 2000
  10. ncbi Beneficial effect of indapamide in experimental myocardial ischemia
    F R Boucher
    Laboratoire de Physiologie Cellulaire Cardiaque, , Grenoble, France
    Am J Hypertens 5:22-5. 1992

Detail Information

Publications169 found, 100 shown here

  1. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
    ..level infections with Schistosoma mansoni, approximately 20% of male CBA/J mice develop hypersplenomegaly syndrome (HSS) while the rest present with moderate splenomegaly syndrome (MSS)...
  2. ncbi Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase
    Tadao Oikawa
    Department of Biotechnology, Faculty of Engineering, Kansai University, 3 3 35 Yamate cho, Suita, Osaka Fu 564 8680, Japan
    J Biotechnol 125:503-12. 2006
    We constructed the high-expression system of the alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli BL 21 (DE3) to characterize the enzymological and structural properties of the gene product, Alr...
  3. pmc Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes
    Chinnasamy Thirunavukkarasu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, E 1542 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Hepatol 48:578-88. 2008
    Augmenter of liver regeneration (ALR), a protein synthesized and stored in hepatocytes, is associated with mitochondria, and possesses sulfhydryl oxidase and cytochrome c reductase activities...
  4. doi Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Free Radic Biol Med 47:1057-66. 2009
    ..Overexpression of ALR significantly increased the mitochondrial membrane potential, inhibited cytochrome c release, and opposed the loss ..
  5. doi Protective effect of augmenter of liver regeneration on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
    Lorenzo Polimeno
    Section of Gastroenterology, Department of Emergency and Organ Transplantation DETO, University of Bari, Bari, Italy
    Free Radic Res 43:865-75. 2009
    ..Disulphide bridges formation is catalysed by sulphydryl oxidase enzymes...
  6. ncbi Augmenter of liver regeneration: its place in the universe of hepatic growth factors
    A Francavilla
    Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213
    Hepatology 20:747-57. 1994
  7. ncbi Identification of hepatopoietin dimerization, its interacting regions and alternative splicing of its transcription
    Yong Li
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center, China
    Eur J Biochem 269:3888-93. 2002
    Hepatopoietin (HPO) is a novel human hepatotrophic growth factor...
  8. ncbi Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway
    Chengrong Lu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center at Beijing, Beijing 100850, P R China
    FASEB J 16:90-2. 2002
    Many growth factors and cytokines are involved in liver regeneration. Of them, only hepatopoietin (HPO)/ALR (augmenter of liver regeneration) is a specifically hepatotrophic factor originally identified from the cytosol of regenerating ..
  9. pmc A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
    T G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:12068-73. 2000
    Proteins of the ERV1/ALR family are encoded by all eukaryotes and cytoplasmic DNA viruses for which substantial sequence information is available. Nevertheless, the roles of these proteins are imprecisely known...
  10. ncbi Beneficial effect of indapamide in experimental myocardial ischemia
    F R Boucher
    Laboratoire de Physiologie Cellulaire Cardiaque, , Grenoble, France
    Am J Hypertens 5:22-5. 1992
    ..after 15 min of reperfusion was significantly reduced; 3) the myocardial content of organic hydroperoxides (HPO), taken as an index of lipid peroxidation, was significantly lowered, whereas the activity of superoxide dismutase (..
  11. ncbi A mutant for the yeast scERV1 gene displays a new defect in mitochondrial morphology and distribution
    D Becher
    , , Jahnstrasse 15a, 17487 Greifswald, Germany
    Yeast 15:1171-81. 1999
    ..The homologous mammalian ALR(Augmenter of Liver Regeneration) genes from man, mouse and rat are important at different developmental stages of ..
  12. ncbi Alpha-chymotrypsin catalysis in imidazolium-based ionic liquids
    J A Laszlo
    New Crops and Processing Research, USDA-ARS, National Center for Agricultural Utilization Research, 1815 N. University St, Peoria, IL 61604 USA
    Biotechnol Bioeng 75:181-6. 2001
    ..alpha-Chymotrypsin freeze-dried with K(2)HPO(4), KCl, or poly(ethylene glycol) demonstrated no activity in [bmim][PF(6)] or [omim][PF(6)] at very low water ..
  13. doi Behaviour and dynamics of di-ammonium phosphate in bauxite processing residue sand in Western Australia--I. NH3 volatilisation and residual nitrogen availability
    C R Chen
    Environmental Futures Centre and Griffith School of Environment, Griffith University, Nathan, Queensland, 4111, Australia
    Environ Sci Pollut Res Int 17:1098-109. 2010
    ..Alcoa currently applies 2.7 t ha(-1) of di-ammonium phosphate ((NH(4))(2)HPO(4); DAP)-based fertiliser as a part of rehabilitation of the outer residue sand embankments of its RDAs...
  14. ncbi [Anti-virus effect of hepatocyte stimulating substance (HSS) on duck hepatitis B virus in vivo]
    G Chen
    The 302 Hospital of PLA, Beijing 100039
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:329-32. 1997
    ..day old Beijing ducklings infected by duck hepatitis B virus as experimental model to observe anti-virus effect of HSS. Beijing ducklings hatched within one day were injected intravenously with duck hepatitis B virus (DHBV)...
  15. ncbi Gene cloning and characterization of alanine racemases from Shigella dysenteriae, Shigella boydii, Shigella flexneri, and Shigella sonnei
    K Yokoigawa
    Department of Food Science and Nutrition, Nara Women s University, Nara, 630 8506, Japan
    Biochem Biophys Res Commun 288:676-84. 2001
    Alanine racemase genes (alr) from Shigella dysenteriae, Shigella boydii, Shigella flexneri, and Shigella sonnei were cloned and expressed in Escherichia coli JM109...
  16. ncbi Mammalian augmenter of liver regeneration protein is a sulfhydryl oxidase
    T Lisowsky
    Botanisches Institut, Henrich Heine Universität Düsseldorf, Germany
    Dig Liver Dis 33:173-80. 2001
    ....
  17. ncbi [Bronchial carcinoma associated with pulmonary osteoarthropathy (Marie-Bamberger)]
    W Pankow
    ,
    Pneumologie 44:1306-11. 1990
    Hypertrophic pulmonary osteoarthropathy (HPO) is characterised by clubbed, or drumstick, fingers and a painful periostitis of the extremities, and occurs most frequently as paraneoplastic symptom in association with bronchial carcinoma...
  18. ncbi Determination of inorganic anions by ion chromatography using a graphitized carbon column dynamically coated with cetyltrimethylammonium ions
    H Nagashima
    Institute of Science and Technology, Inc, Tokyo, Japan
    J Chromatogr A 855:261-6. 1999
    ..in the eluent were examined to optimize the separation of seven common anions (F-, Cl-, NO2-, Br-, NO3-, HPO(4)2- and SO(4)2-). Calibration curves were linear from 0.5 to 5 micrograms/ml for F-, from 1...
  19. ncbi Differential response of retinoic acid pretreated human synovial sarcoma cell line to anticancer drugs
    M Adwankar
    Chemotherapy Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 77:391-4. 1991
    The response of tumorigenic human synovial sarcoma (HSS) cell line to 10(-5)M optimum concentration of retinoic acid (RA) included changes in morphology, growth rate, suppression of anchorage-independent growth, induction of high ..
  20. pmc A novel assay method for an amino acid racemase reaction based on circular dichroism
    Masafumi Noda
    Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8551, Japan
    Biochem J 389:491-6. 2005
    ..based on circular dichroism that can be used for the kinetic study of the activity of amino acid racemases, such as ALR (alanine racemase)...
  21. ncbi [Medin modular implant for total knee arthroplasty--mid-term results]
    P Vavrik
    I ortopedická klinika 1 LF UK a FN Motol, Praha
    Acta Chir Orthop Traumatol Cech 76:30-4. 2009
    ..Pain, range of motion, stability and function were scored on a 100-point scale of the Hospital for Special Surgery (HSS) Scoring System. Subjective satisfaction was essessed by the patient's willingness to undergo the surgery again...
  22. ncbi Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, Taiwan
    Pharmacogenet Genomics 16:297-306. 2006
    ..causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
  23. doi Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure
    Gilles Francony
    Department of Anesthesiology and Critical Care, Albert Michallon Hospital, Grenoble, France
    Crit Care Med 36:795-800. 2008
    To compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HSS) in the treatment of patients with sustained elevated intracranial pressure (ICP).
  24. pmc An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
    T Lewis
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 74:1275-85. 2000
    The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while ALR has hepatotrophic activity...
  25. doi Time-dependent alginate/polyvinyl alcohol hydrogels as injectable cell carriers
    Sang Ho Cho
    Department of Advanced Materials, Hannam University, 461 6 Jeonmin Dong, Yuseong Gu, Daejeon 305 811, South Korea
    J Biomater Sci Polym Ed 20:863-76. 2009
    ..alcohol (PVA) blend hydrogels with controllable gelation rate by using CaSO(4) as a cross-linking agent and Na(2)HPO(4) as a cross-linking retardation agent...
  26. doi Impairment of D-alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human macrophages
    Ofelia Chacon
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, NE 68583, USA
    Microbiology 155:1440-50. 2009
    ..in eubacteria is the enantiomeric conversion from l-alanine, a reaction catalysed by d-alanine racemase (Alr)...
  27. ncbi Effects of small- and large-volume resuscitation on coagulation and electrolytes during experimental endotoxemia in anesthetized horses
    Lucas G Pantaleon
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA
    J Vet Intern Med 21:1374-9. 2007
    ..of a larger project, the objective of this study was to determine the effects of SVR (hypertonic saline solution [HSS] plus hetastarch [HES]) on coagulation and serum electrolytes concentration, and to compare SVR with large- and ..
  28. ncbi Radiotherapy in painful heel spurs (plantar fasciitis)--results of a national patterns of care study
    Oliver Micke
    Department of Radiotherapy, Munster University Hospital, Munster, Germany
    Int J Radiat Oncol Biol Phys 58:828-43. 2004
    After a general patterns of care study, the German Cooperative Group on Radiotherapy for Benign Diseases conducted a multicenter cohort study to analyze radiotherapy (RT) in painful heel spur syndrome (HSS).
  29. pmc Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation
    Geoffrey K Kilili
    Molecular Cardiology Research Institute, Tufts Medical Center, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 285:15076-87. 2010
    ..Studies of Drosophila suggest that Hippo (hpo) is required for inhibition of cell proliferation mediated by dMer, the orthologue of human merlin...
  30. ncbi Targeting enzymes involved in spermidine metabolism of parasitic protozoa--a possible new strategy for anti-parasitic treatment
    A Kaiser
    Institute for Medical Parasitology, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Parasitol Res 91:508-16. 2003
    ..falciparum, i.e. deoxyhypusine synthase (DHS; EC 1.1.1.249) and homospermidine synthase (HSS; EC 2.5.1.45)...
  31. ncbi A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes
    Rimtautas Gudas
    Department of Orthopaedics and Trauma, Kaunas University Hospital, Kaunas, Lithuania
    Arthroscopy 21:1066-75. 2005
    ....
  32. ncbi [Balancing of soft tissues in total knee arthroplasty for patients with rheumatoid arthritis with knee flexion contracture]
    Weijun Wang
    Department of Clinical Medicine, Ningxia Medical College School, Yinchuan Ningxia 750004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:1173-6. 2008
    ..To explore the technique of the soft tissue balancing in the total knee arthroplasty (TKA) for the patients of rheumatoid arthritis with flexion contracture...
  33. ncbi Iridium Ziegler-type hydrogenation catalysts made from [(1,5-COD)Ir(mu-O2C8H15)](2) and AlEt3: spectroscopic and kinetic evidence for the Ir(n) species present and for nanoparticles as the fastest catalyst
    William M Alley
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Inorg Chem 49:8131-47. 2010
    Ziegler-type hydrogenation catalysts, those made from a group 8-10 transition metal precatalyst and an AlR(3) cocatalyst, are often used for large scale industrial polymer hydrogenation; note that Ziegler-type hydrogenation catalysts are ..
  34. ncbi Nucleation and elongation of actin filaments in the presence of high speed supernate from neutrophil lysates: modulating effects of Ca2+ and phosphatidylinositol-4,5-bisphosphate
    M J DiNubile
    Division of Infectious Diseases, Department of Medicine, Cooper Health System, UMDNJ Robert Wood Johnson Medical School, Camden, NJ, USA
    Biochim Biophys Acta 1405:85-98. 1998
    ..High speed supernates (HSS) of dilute neutrophil lysates contain actin monomers and/or oligomers that can be induced to polymerize by certain ..
  35. ncbi Cardiovascular and pulmonary effects of hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses
    Lucas G Pantaleon
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA
    J Vet Intern Med 20:1422-8. 2006
    ..The objective of this study was to determine the cardiopulmonary effects of small-volume resuscitation using hypertonic saline solution (HSS) plus Hetastarch (HES) during experimental endotoxemia in anesthetized horses.
  36. ncbi Shelf lives of aseptically prepared medicines--stability of hydrocortisone sodium succinate in PVC and non-PVC bags and in polypropylene syringes
    Diane Clare Rigge
    Quality Control North West, Stepping Hill Hospital, Poplar Grove, Stockport, Cheshire SK2 7JE, UK
    J Pharm Biomed Anal 38:332-6. 2005
    Parenteral aseptic preparations of hydrocortisone sodium succinate (HSS) are used frequently in hospitals, but little definitive stability information is available...
  37. doi Monitoring stress levels in postgraduate medical training
    Justin D Hill
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1078, USA
    Laryngoscope 119:75-8. 2009
    ..and a low degree of personal accomplishment using the Maslach Burnout Inventory-Human Services Survey (MBI-HSS)...
  38. doi Open reduction and internal fixation compared with circular fixator application for bicondylar tibial plateau fractures. Surgical technique
    Jeremy A Hall
    Division of Orthopaedics, Department of Surgery, St Michael s Hospital and the University of Toronto, 55 Queen Street East, Suite 800, Toronto, ON M5C 1R6, Canada
    J Bone Joint Surg Am 91:74-88. 2009
    ..To our knowledge, there has been no direct comparison of the two operative approaches...
  39. ncbi Five percent, 7.5% or 10% hypertonic saline prevents delayed neuronal death in gerbils
    Shinsuke Hamaguchi
    Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Can J Anaesth 49:745-8. 2002
    To clarify the appropriate concentration and dose of hypertonic saline solution (HSS) for preventing delayed neuronal death in the hippocampal CA1 subfield after transient forebrain ischemia in gerbils.
  40. ncbi The influence of limited postoperative weight-bearing on the outcome of drilling in osteochondritis dissecans tali
    Michael Bohnsack
    Department of Orthopedic Surgery, Hannover Medical School, Anna von Borries Str 1 7, 30625 Hannover, Germany
    Arch Orthop Trauma Surg 123:447-50. 2003
    ..This prospective study was performed to assess the influence of limited weight-bearing on the outcome of osteochondral drilling in the treatment of an osteochondritis dissecans tali...
  41. pmc Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
    Dalei Wu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People s Republic of China
    Protein Sci 17:1066-76. 2008
    Alanine racemase (Alr) is an important enzyme that catalyzes the interconversion of L-alanine and D-alanine, an essential building block in the peptidoglycan biosynthesis...
  42. doi Effect of specific anion on templated crystal nucleation at the liquid-liquid interface
    Sunghee Lee
    Department of Chemistry, Iona College, New Rochelle, New York 10801, USA
    Langmuir 26:9556-64. 2010
    ..The salts used were K(2)HPO(4), KCl, KBr, KI, KNO(3), and KSCN, present at an initial concentration of 10 mM within an aqueous microdroplet ..
  43. ncbi Hallermann-Streiff syndrome associated with small cerebellum, endocrinopathy and increased chromosomal breakage
    J W Hou
    Division of Medical Genetics and Metabolism, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Acta Paediatr 92:869-71. 2003
    Hallermann-Streiff syndrome (HSS) is a rare clinic entity of unknown aetiology. Further clinical and metabolic-genetic evaluations are indicated...
  44. doi Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency
    Mark Stroh
    Department of Clinical Drug Metabolism, Merck Research Laboratories, West Point, PA 19486 0004, USA
    Am J Ther 16:379-84. 2009
    ..laropiprant 40-mg dose in 8 nondialyzed, severe renal insufficiency patients (RIs) with healthy matched subjects (HSs) (24-hour creatinine clearance <30 mL/min/1.73 m(2) and >80 mL/min/1.73 m(2) for RIs and HSs, respectively)...
  45. pmc An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene
    Tomoko Hiroki
    Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:7365-80. 2007
    ..A minimal hDBP transgene, containing a defined set of liver-specific DNase I hypersensitive sites (HSs), is robustly expressed in mouse liver in a copy-number-dependent manner. Here we evaluate these HSs for function...
  46. doi A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway
    Jyoti Rath
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Gene 429:1-9. 2009
    ..The gene encoding aldose reductase (ALR) has been cloned from Leishmania donovani, a protozoan parasite causing visceral leishmaniasis...
  47. doi Genetic recombinant expression and characterization of human augmenter of liver regeneration
    Chun fang Gao
    Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200438, China
    Dig Dis Sci 54:530-7. 2009
    ..To establish a highly effective prokaryotic recombinant expression system for human augmenter of liver regeneration (hALR) and to characterize the recombinant hALR both in vitro and in vivo...
  48. ncbi Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region
    Q Li
    School of Medicine, University of Washington, Seattle, Washington, 98195, USA
    Genomics 61:183-93. 1999
    ..The LCR is composed of five DNase I hypersensitive sites (HSs), four of which are formed in erythroid cells. The function of the 5'-most site, HS5, remains unknown...
  49. ncbi Heterologous expression of a bacterial homospermidine synthase gene in transgenic tobacco: effects on the polyamine pathway
    Annette Kaiser
    Institut für Medizinische Parasitologie, Bonn, Germany
    Arch Pharm (Weinheim) 335:143-51. 2002
    Homospermidine synthase (HSS) is a branch-point enzyme that links the secondary pathway (pyrrolizidine alkaloids) to primary metabolism (polyamines)...
  50. doi Head, arm and trunk coordination during reaching in children
    H Sveistrup
    Faculty of Health Sciences, University of Ottawa, Ottawa, Canada
    Exp Brain Res 188:237-47. 2008
    ..HST) or "en bloc" pattern was observed with approximately the same frequency as a head-stabilized-in-space (HSS) pattern in the youngest children in the yaw plane for reaches within arm's length...
  51. ncbi [Clinical analysis of 13 infected total knee replacements]
    B Kou
    Arthritis and Clinic Research Center, People's Hospital, Beijing Medical University, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 38:253-5. 2000
    ..The preoperative average ROM of knees was 55 degrees and the average Hospital for Special Surgery (HSS) knee score was 36.5 points. Clinical results were evaluated after average follow-up for 3 years and 5 months...
  52. ncbi [Anterior cruciate ligament reconstruction using periosteum wrapped autologous hamstring tendons: clinical research]
    Ran Sun
    Department of Orthopedic Surgery, Third Hosipital of Heibei Medical University, Shijiazhuang 050051, China
    Zhonghua Yi Xue Za Zhi 90:182-6. 2010
    ..To develop a surgical technique using a periosteal flap wrapped autologous hamstring tendons in ACL reconstruction and to examine its short-term outcome...
  53. ncbi Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure
    D B Jump
    Department of Physiology, Michigan State University, East Lansing 48824
    J Biol Chem 265:3474-8. 1990
    ..hypothyroid rats inhibited the formation of three DNase I-hypersensitive sites flanking the 5'-end of the S14 gene (Hss-1 at -65 to -265 base pairs; Hss-2 at -1.2 kilobases and Hss-3 at -2.67 kilobases)...
  54. ncbi Removal of dissolved organic matter by granular-activated carbon adsorption as a pretreatment to reverse osmosis of membrane bioreactor effluents
    Shirra Gur-Reznik
    Faculty of Civil and Environmental Engineering and Grand Water Research Institute, Technion Israel Institute of Technology, Haifa 32000, Israel
    Water Res 42:1595-605. 2008
    ..The pattern and efficiency of DOM adsorption and fate of the hydrophobic (HPO), transphilic (TPI) and hydrophilic (HPI) fractions were characterized, as well as their impact on organic fouling ..
  55. pmc Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells
    Chandrashekhar R Gandhi
    VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA
    J Cell Physiol 222:365-73. 2010
    Mitogenic effect of augmenter of liver regeneration (ALR), a protein produced and released by hepatocytes, on hepatocytes in vivo but not in vitro suggests that the effect is mediated by nonparenchymal cells...
  56. doi Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity
    K Sartorius
    Section of Dermatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Br J Dermatol 161:831-9. 2009
    ..The disease is difficult to treat and has a severe impact on quality of life. A clinically relevant system for scoring disease severity is lacking in HS...
  57. doi The effect of pressure on the phase transition behavior of tridecane, pentadecane, and heptadecane: a Fourier transform infrared spectroscopy study
    Motoi Yamashita
    College of Pharmaceutical Sciences, Ritsumeikan University, 1 1 1 Noji higashi, Kusatsu, Shiga 525 8577, Japan
    J Chem Phys 134:144503. 2011
    ..The transition between the high pressure ordered (HPO) and high pressure rotator (HPR) phases has been observed in the pressure ranges of 270-220, 106-95, and 152-181 ..
  58. ncbi [Cloning, sequence analysis and expression of alanine racemase gene in Pseudomonas putida]
    Qin Cao
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Wei Sheng Wu Xue Bao 46:80-4. 2006
    ..DadX encodes a peptide of 357 amino acids with a calculated molecular weight of 38.82kDa. The putative product of alr gene is a peptide of 409 amino acids with molecular weight of 44.182kDa...
  59. ncbi Improved estimates of India's HIV burden in 2006
    Arvind Pandey
    National Institute of Medical Statistics, ICMR, New Delhi, India
    Indian J Med Res 129:50-8. 2009
    HIV estimates in India were based on HIV sentinel surveillance (HSS) data and several assumptions...
  60. ncbi Intra-articular fractures of the distal femur: a long-term follow-up study of surgically treated patients
    Maarten V Rademakers
    Department of Orthopaedic Surgery, Academic Medical Center, G4 259, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Orthop Trauma 18:213-9. 2004
    ..To analyze the long-term (5-25 years) functional and radiologic results of surgically treated intra-articular fractures of the distal femur...
  61. pmc Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy
    Vidyadhar N Daithankar
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biochemistry 49:6737-45. 2010
    The sulfhydryl oxidase augmenter of liver regeneration (ALR) binds FAD in a helix-rich domain that presents a CxxC disulfide proximal to the isoalloxazine ring of the flavin...
  62. ncbi [Comparison of short-term result between high-flex and conventional posterior-stabilized prosthesis in total knee arthroplasty]
    Jin Li
    Department of Orthopedics, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo Zhejiang, 315040, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:278-81. 2010
    ..To compare the short-term result between the high-flex (HF) and conventional posterior-stabilized (PS) prosthesis in total knee arthroplasty (TKA)...
  63. doi Generation and characterization of thymidine/D-alanine auxotrophic recombinant Lactococcus lactis subsp. lactis IL1403 expressing BmpB
    Eun Bae Kim
    Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Curr Microbiol 61:29-36. 2010
    ..lactis subsp. lactis IL1403 strains expressing a heterologous protein, BmpB, using thyA- and alr-targeting integration vectors: ITD (thyA(-)alr(+) bmpB(+)), IAD (thyA(+)alr(-)bmpB(+)), and ITDAD (thyA(-)alr(-) ..
  64. doi Age and stress as determinants of the severity of hyperthyroidism caused by Graves' disease in newly diagnosed patients
    Xander G Vos
    Department of Endocrinology and Metabolism, F5 161, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Endocrinol 160:193-9. 2009
    ..We tested the hypothesis whether advancing age is associated with less exposure to stress, resulting in a lower immunological response, and less severe Graves' hyperthyroidism...
  65. ncbi Reactivity and selectivity of the N-acetyl-Glu-P-1, N-acetyl-Glu-P-2, N-acetyl-MeIQx, and N-acetyl-IQx nitrenium ions: comparison to carbocyclic N-arylnitrenium ions
    Michael Novak
    Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, USA
    J Am Chem Soc 124:7972-81. 2002
    ..The reactions of the nitrenium ions with AcO(-), HPO(4)(2-), N(3)(-), and 2'-deoxyguanosine (d-G) were characterized in aqueous solution by using a combination of ..
  66. ncbi Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite
    Tunhan Chang
    Division of Biological Chemistry and Molecular Microbiology, The Wellcome Trust Biocentre, The School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:50176-82. 2002
    ..anchor biosynthesis in all eukaryotes is the conversion of D-GlcNAcalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol (GlcNAc-PI) to d-GlcNalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol by GlcNAc-PI ..
  67. ncbi Persistent transforming growth factor-beta 1 expression may predict peritoneal fibrosis in CAPD patients with frequent peritonitis occurrence
    C Y Lin
    Department of Pediatrics, Veterans General Hospital, Taipei, Taiwan
    Am J Nephrol 18:513-9. 1998
    ..before onset, once a week during peritonitis, and after peritonitis in high and low peritonitis occurrence (HPO and LPO) patients. Fifteen patients with a LPO rate and 5 patients with a HPO rate were followed up longitudinally...
  68. doi Characterization of biofilm formation on a humic material
    A L Rodrigues
    Institute for Biotechnology and Bioengineering IBB, Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4700 057, Braga, Portugal
    J Ind Microbiol Biotechnol 35:1269-76. 2008
    ..The present work intends to study biofilm formation in the presence of humic substances (HSs) as a carbon source...
  69. doi The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data
    Sebastian Kohler
    Institute for Medical Genetics and Human Genetics, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Berlin Brandenburg Center for Regenerative Therapies, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Lawrence Berkeley National Laboratory, Mail Stop 84R0171, Berkeley, CA 94720, USA, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK, Department of Medical Genetics, Cambridge University Addenbrooke s Hospital, Cambridge CB2 2QQ, UK, Universite Paul Sabatier, Faculte de Chirurgie Dentaire, CHU Toulouse, France, Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre MAHSC, Manchester, UK, Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, MAHSC, Manchester M13 9WL, UK, Institute of Genetic Medicine Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK, Department of Computer Science, University of Toronto, Ontario, Canada
    Nucleic Acids Res 42:D966-74. 2014
    The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology...
  70. ncbi Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c
    Scott Allen
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Mol Biol 353:937-44. 2005
    ..Here, we show that the mitochondrial flavin adenine dinucleotide (FAD)-linked sulfhydryl oxidase Erv1 (essential for respiration and vegetative growth 1) plays a central role in the biogenesis of small, cysteine ..
  71. ncbi Tooth whitening products and the risk of oral cancer
    I C Munro
    Cantox Health Sciences International, Mississauga, ON, Canada
    Food Chem Toxicol 44:301-15. 2006
    Tooth whitening products (TWP) containing hydrogen peroxide (HPO) or carbamide peroxide (CPO) were evaluated in relation to potential oral cancer risk from their use. HPO is genotoxic in vitro, but such activity is not expressed in vivo...
  72. pmc Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine
    Zhengyu Feng
    Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583 0905, USA
    Antimicrob Agents Chemother 47:283-91. 2003
    D-Cycloserine (DCS) targets the peptidoglycan biosynthetic enzymes D-alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl)...
  73. ncbi Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product
    Masafumi Noda
    Department of Molecular Microbiology and Biotechnology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    J Biol Chem 279:46153-61. 2004
    Alanine racemase (ALR), an enzyme that catalyzes the interconversion of Ala enantiomers, is essential for the synthesis of the bacterial cell wall...
  74. ncbi Comparison of endoscopic, necropsy and histology scoring of equine gastric ulcers
    F M Andrews
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville 37901 1071, USA
    Equine Vet J 34:475-8. 2002
    ..The gastric ulcers were scored using a histopathology system (HSS) based on ulcer depth...
  75. ncbi Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate
    Keju Jing
    Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, PR China
    Prep Biochem Biotechnol 35:203-15. 2005
    An NADPH-dependent aldehyde reductase (ALR, EC1.1.1.2) gene is cloned from Sporobolomyces salmonicolor ZJUB 105, and inserted into plasmid pQE30 to construct the expression plasmid (pQE30-ALR). A variety of E...
  76. pmc Adenoviral gene transfer of hepatic stimulator substance confers resistance against hepatic ischemia-reperfusion injury by improving mitochondrial function
    Shu Jun Jiang
    Department of Cell Biology and Municipal Laboratory of Liver Protection and Regulation of Regeneration, Capital Medical University, 100069 Beijing, China
    Hum Gene Ther 24:443-56. 2013
    Hepatic stimulator substance (HSS) has been suggested to protect liver cells from various toxins. However, the precise role of HSS in hepatic ischemia-reperfusion (I/R) injury remains unknown...
  77. pmc Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association
    Hong Ling Huang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
    PLoS Biol 11:e1001620. 2013
    The evolutionarily conserved Hippo (Hpo) signaling pathway plays a pivotal role in organ size control by balancing cell proliferation and cell death...
  78. pmc Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration
    Rania Dayoub
    Department of Pediatrics and Juvenile Medicine, University of Regensburg Hospital, Germany
    Mol Med 19:237-44. 2013
    ..A variety of factors regulate hepatic tissue regeneration, among them augmenter of liver regeneration (ALR), attained great attention as being survival factors for the liver with proproliferative and antiapoptotic ..
  79. doi Protective effect of augmenter of liver regeneration on vincristine-induced cell death in Jurkat T leukemia cells
    Yan Shen
    Chongqing Medical University, Chongqing, China
    Int Immunopharmacol 17:162-7. 2013
    Augmenter of liver regeneration (ALR) is a crucial factor in the process of proliferation of hepatocytes...
  80. ncbi Structure of oligosaccharide side chains of an intestinal immune system modulating arabinogalactan isolated from rhizomes of Atractylodes lancea DC
    Ikue Taguchi
    Kitsato Institute for Life Sciences and Graduate school of Pharmaceutical Sciences, Kitasato University, Minato ku, Tokyo 108 8642, Japan
    Carbohydr Res 339:763-70. 2004
    An intestinal immune system modulating arabino-3,6-galactan (ALR-5IIa-1-1) has been found in rhizomes of Atractylodes lancea DC. [Planta Medica 1998, 64, 714-719; Carbohydr. Polyms...
  81. doi Exploiting the use of 3,4-HPO ligands as nontoxic reagents for the determination of iron in natural waters with a sequential injection approach
    Raquel B R Mesquita
    CBQF Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia, Centro Regional do Porto da Universidade Católica Portuguesa, R Dr António Bernardino de Almeida 4200 072 Porto, Portugal
    Talanta 108:38-45. 2013
    In this paper, the use of 3-hydroxy-4-pyridinone (3,4-HPO) chelators as nontoxic chromogenic reagents for iron determination is proposed. The potential application of these compounds was studied in a sequential injection system...
  82. doi Augmenter of liver regeneration inhibits apoptosis of activated human peripheral blood lymphocytes in vitro
    Na Wang
    Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education of China, Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Immunopharmacol Immunotoxicol 35:257-63. 2013
    ..Recently it has been demonstrated that augmenter of liver regeneration (ALR), an enigmatic protein presented ubiquitously in multiple forms among eukaryotes, possesses potent anti-apoptotic ..
  83. pmc Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    Mol Med 18:1421-9. 2012
    ..Augmenter of liver regeneration (ALR) protein, expressed and secreted by hepatocytes, promotes liver regeneration and maintains viability of hepatocytes...
  84. doi Augmenter of liver regeneration may be a candidate for prognosis of HBV related acute-on-chronic liver failure as a regenerative marker
    Shi Hongbo
    Beijing Artificial Liver Treatment and Training Centre, Beijing Youan Hospital, Affiliated Hospital of Capital Medical University, Beijing, China
    Hepatogastroenterology 59:1933-8. 2012
    ..To search for a new regenerative marker to estimate the prognosis of acute-on-chronic liver failure (ACLF)...
  85. doi Setting solution concentration effect on properties of a TTCP/DCPA-derived calcium phosphate cement
    Chang Keng Chen
    Department of Materials Science and Engineering, National Cheng Kung University, No 1 University Road, 70101, Tainan, Taiwan, ROC
    J Mater Sci Mater Med 23:2109-14. 2012
    The present work was to investigate the effects of concentration of (NH(4))(2)HPO(4) (diammonium hydrogen phosphate) setting solution on properties of a tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA)--derived calcium ..
  86. ncbi Recruitment of alkaloid-specific homospermidine synthase (HSS) from ubiquitous deoxyhypusine synthase: Does Crotalaria possess a functional HSS that still has DHS activity?
    Niknik Nurhayati
    Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
    Phytochemistry 66:1346-57. 2005
    ..of plant secondary metabolism in this tribe, we have searched for a cDNA coding for homospermidine synthase (HSS), the enzyme catalyzing the first specific step in this biosynthesis...
  87. pmc Divergent molecular evolution of the mitochondrial sulfhydryl:cytochrome C oxidoreductase Erv in opisthokonts and parasitic protists
    Elisabeth Eckers
    Department of Parasitology, Ruprecht Karls University, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Biol Chem 288:2676-88. 2013
    Mia40 and the sulfhydryl:cytochrome c oxidoreductase Erv1/ALR are essential for oxidative protein import into the mitochondrial intermembrane space in yeast and mammals...
  88. ncbi Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax
    R Prasad
    Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 15:549-60. 1997
    ..We have cloned a novel human gene, ALR, which encodes a gigantic 5262 amino acid long protein containing a SET domain, five PHD fingers, potential zinc ..
  89. ncbi Functional comparison of the yeast scERV1 and scERV2 genes
    G Stein
    Botanisches Institut, , Germany
    Yeast 14:171-80. 1998
    ..The homologous mammalian ALR (augmenter of liver regeneration) genes from man, mouse and rat are important for different developmental stages of ..
  90. ncbi Rapid induction of PC3/BTG2 gene by hepatopoietin or partial hepatectomy and its mRNA expression in hepatocellular carcinoma
    Zhi min Zhang
    Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    Hepatobiliary Pancreat Dis Int 8:288-93. 2009
    ..This study aimed to assess the effects of recombinant human hepatopoietin (HPO) and partial hepatectomy on rapidly induced expression of immediate-early genes and to investigate the expression ..
  91. doi Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes
    Niknik Nurhayati
    Institut fur Pharmazeutische Biologie, TU Braunschweig, Mendelssohnstr 1, D 38106 Braunschweig, Germany
    Phytochemistry 70:508-16. 2009
    ..PAs are regarded as part of the plant's constitutive defense against herbivores. Homospermidine synthase (HSS) is the first specific enzyme of PA biosynthesis...
  92. ncbi Increased levels of interleukin 5 are associated with the generation of eosinophilia in drug-induced hypersensitivity syndrome
    G Choquet-Kastylevsky
    Department of Dermatology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
    Br J Dermatol 139:1026-32. 1998
    Hypersensitivity syndrome (HSS) usually refers to severe drug eruption associated with systemic symptoms and eosinophilia...
  93. ncbi Hysteroscopic selective salpingography
    N Inagaki
    Department of Obstetrics and Gynecology, Social Insurance Saitama Chuo Hospital, Urawa, Japan
    Fertil Steril 72:733-6. 1999
    To evaluate the effectiveness of hysteroscopic selective salpingography (HSS) as a method for diagnosing the tubal proximal occlusion shown by hysterosalpingography (HSG).
  94. pmc An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins
    H Lange
    Institut für Zytobiologie und Zytopathologie der Philipps Universität Marburg, Robert Koch Strasse 5, 35033 Marburg, Germany
    EMBO Rep 2:715-20. 2001
    ..Furthermore, Erv1p was found to be important for cellular iron homeostasis. The homologous mammalian protein ALR ('augmenter of liver regeneration'), also termed hepatopoietin, can functionally replace defects in Erv1p and thus ..
  95. doi Policy-contribution assessment and field-building analysis of the Robert Wood Johnson Foundation's Active Living Research Program
    Judith M Ottoson
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Am J Prev Med 36:S34-43. 2009
    The Robert Wood Johnson Foundation requested this utilization-focused evaluation of its Active Living Research (ALR) program...
  96. doi Different natural organic matter isolates cause similar stress response patterns in the freshwater amphipod, Gammarus pulex
    Darya S Bedulina
    Irkutsk State University, Ul Karl Marx 1, 664003, Irkutsk, Russia
    Environ Sci Pollut Res Int 17:261-9. 2010
    Dissolved humic substances (HSs) are exogenous stressors to aquatic plants and animals which activate a variety of transcriptional and biochemical reactions or block photosynthesis...
  97. ncbi Acidic fibroblast growth factor attenuates the cytotoxic effects of peroxynitrite in primary human osteoblast precursors
    D A Reiff
    Center for Injury Sciences, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Trauma 50:433-8; discussion 439. 2001
    ..In vitro studies were performed examining the effect of FGF-1 on human osteoblast progenitor stromal stem (HSS) cell proliferation, differentiation, and response to ONOO-.
  98. ncbi Anterior cruciate ligament reconstruction in men and women: An outcome analysis comparing gender
    J D Ferrari
    Section of Sports Medicine, Department of Orthopaedics, Rush Medical College, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, U S A
    Arthroscopy 17:588-96. 2001
    ..The purpose of this study was to evaluate the effect gender has on outcome in ACL reconstruction using bone-patellar tendon-bone autograft...
  99. doi Evaluation of Active Living Research progress and lessons in building a new field
    Marjorie A Gutman
    Gutman Research Associates, Cranbury, New Jersey, USA
    Am J Prev Med 36:S22-33. 2009
    An evaluation was undertaken of the initial 6 years of the Active Living Research (ALR) program...
  100. doi Linking programmes and systems: lessons from the GAVI Health Systems Strengthening window
    B Galichet
    Department of Country Focus, World Health Organization, Geneva, Switzerland
    Trop Med Int Health 15:208-15. 2010
    To analyse the first four rounds of country applications to the GAVI Alliance Health Systems Strengthening (GAVI-HSS) funding window; to provide valuable insight into how countries prioritize, articulate and propose solutions for health ..
  101. ncbi Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction
    Rei Ogawa
    Department of Plastic, Reconstructive and Regenerative Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 78:68-76. 2011
    We use evidence-based algorithms to treat abnormal scarring, including keloids and hypertrophic scars (HSs)...

Research Grants75

  1. Novel genetic tools for Burkholderia mallei and other bacterial Select Agents
    Randall Holmes; Fiscal Year: 2007
    ..We will use the alanine racemase (alr) gene as a selectable genetic marker for the studies proposed here...
  2. Pathobiology of a heme inducible transporter in Staphylococcus aureus
    Eric P Skaar; Fiscal Year: 2010
    ..aureus machinery responsible for this adaptive response: the heme sensor system (Hss) and the heme regulated transporter (Hrt)...
  3. STRUCTURE OF ANTIMITOGENIC MESANGIAL HEPARAN SULFATES
    Aimin Wang; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Heparan sulfates (HSs) and heparin, proposed as endogenous defending molecules in the "glomerular self-defense", are inhibitors of mesangial cell growth in human proliferative nephritides, in ..
  4. MOLECULAR BASIS OF SYNDROMIC RETINITIS PIGMENTOSA
    Susan Hayflick; Fiscal Year: 2003
    ..and characterize the gene for a form of syndromic retinitis pigmentosa (RP), called Hallervorden-Spatz syndrome (HSS) and characterized by abnormal electroretinogram, lipofuscin accumulation in the retinal pigment epithelium, and ..
  5. RISK-TAKING, ALCOHOL, AND HIV PREVENTION IN YOUTH
    Rick Zimmerman; Fiscal Year: 2001
    ..research, we expect that high school-age students who are high on sensation-seeking and impulsive decision-makers (HSS/IDM) will be particularly difficult to reach using conventional skills-based classroom curricula...
  6. BIOGENESIS OF THE MITOCHONDRIAL INNER MEMBRANE
    Carla M Koehler; Fiscal Year: 2010
    ..The TIM22 import pathway and the Erv1/Mia40 oxidative folding pathway will be targeted...
  7. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  8. Targeting Mass Media Campaigns for HIV, STD, and Pregnancy Prevention
    Rick Zimmerman; Fiscal Year: 2007
    ..impressive, with 4-6 month effects on condom use and critical mediators of condom use for high-sensation-seeking (HSS) and impulsive decision-making (IDM) young adults in an interrupted time-series, 2-city field experiment...
  9. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2007
    ..data, we propose that enzymes which degrade matrix heparan sulfate proteoglycans (HSPGs) and heparan sulfates (HSs) are generated following MCA:O, simultaneously with the matrix metalloproteinase pro-MMP-2, and are responsible for ..
  10. RISK-TAKING, ALCOHOL, AND HIV PREVENTION IN YOUTH
    Rick Zimmerman; Fiscal Year: 2003
    ..research, we expect that high school-age students who are high on sensation-seeking and impulsive decision-makers (HSS/IDM) will be particularly difficult to reach using conventional skills-based classroom curricula...
  11. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    ..The ALR mouse is closely related to NOD as evidenced by genetic identity for markers at multiple "Idd" (diabetes ..
  12. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2010
    ..last project period has allowed us to delineate a Hippo kinase cascade comprised of the Ste20-like kinase Hippo (Hpo), the NDR family kinase Warts (Wts), and the transcriptional co activator Yorkie (Yki)...
  13. DEPO-PROVERA AND BONE DENSITY IN PREMENOPAUSAL WOMEN
    M Clark; Fiscal Year: 2003
    ..Because DMPA disrupts the hypothalamic-pituitary-ovarian-axis (HPO), it theoretically will suppress estrogen production causing a relative estrogen deficiency, and corresponding loss ..
  14. Pathobiology of a heme inducible transporter in Staphylococcus aureus
    Eric P Skaar; Fiscal Year: 2011
    ..aureus machinery responsible for this adaptive response: the heme sensor system (Hss) and the heme regulated transporter (Hrt)...
  15. FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMES
    William T Garrard; Fiscal Year: 2010
    ..regions in Ig: chromatin that contain B-cell-specific and developmentally regulated DNase I hypersensitive sites (HSs): (1) A silencer (Sis) within the intervening sequence between the joining (J?) region and the most proximal V? ..
  16. FUNCTION AND CONSERVATION IN GLOBIN LOCUS CONTROL REGION
    Ross Hardison; Fiscal Year: 2001
    ..LCR) is a major regulator of mammalian beta-like globin genes, and is marked by 5 DNase hypersensitive sites (HSs)...