GFAP

Summary

Gene Symbol: GFAP
Description: glial fibrillary acidic protein
Alias: ALXDRD, glial fibrillary acidic protein
Species: human
Products:     GFAP

Top Publications

  1. Misu T, Takano R, Fujihara K, Takahashi T, Sato S, Itoyama Y. Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker. J Neurol Neurosurg Psychiatry. 2009;80:575-7 pubmed publisher
    ..Recent studies have revealed that loss of aquaporin 4 and glial fibrillar acidic protein (GFAP) is a prominent feature of NMO lesions, suggesting astrocytic impairment...
  2. Besnard F, Brenner M, Nakatani Y, Chao R, Purohit H, Freese E. Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein. J Biol Chem. 1991;266:18877-83 pubmed
    The gfa gene encodes glial fibrillary acidic protein, an intermediate filament protein found almost exclusively in astrocytes...
  3. Blechingberg J, Holm I, Nielsen K, Jensen T, Jørgensen A, Nielsen A. Identification and characterization of GFAPkappa, a novel glial fibrillary acidic protein isoform. Glia. 2007;55:497-507 pubmed
    b>Glial fibrillary acidic protein (GFAP) is the principal component of the intermediary filaments in mature astrocytes of the central nervous system (CNS). The protein consists of three domains: the head, the coiled-coil, and the tail...
  4. Okonkwo D, Yue J, Puccio A, Panczykowski D, Inoue T, McMahon P, et al. GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma. 2013;30:1490-7 pubmed publisher
    Reliable diagnosis of traumatic brain injury (TBI) is a major public health need. Glial fibrillary acidic protein (GFAP) is expressed in the central nervous system, and breakdown products (GFAP-BDP) are released following parenchymal ..
  5. Casper K, McCarthy K. GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci. 2006;31:676-84 pubmed
    ..Cre/loxP fate-mapping experiments were carried out using a fragment of a glial-specific promoter (glial fibrillary acidic protein; GFAP) to drive expression of Cre recombinase...
  6. Restrepo A, Smith C, Agnihotri S, Shekarforoush M, Kongkham P, Seol H, et al. Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas. Neuro Oncol. 2011;13:42-50 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is an intermediate filament expressed in glial cells that stabilizes and maintains the cytoskeleton of normal astrocytes...
  7. Flint D, Li R, Webster L, Naidu S, Kolodny E, Percy A, et al. Splice site, frameshift, and chimeric GFAP mutations in Alexander disease. Hum Mutat. 2012;33:1141-8 pubmed publisher
    ..disease (AxD) is a usually fatal astrogliopathy primarily caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament protein expressed in astrocytes...
  8. Nielsen A, Jørgensen A. Self-assembly of the cytoskeletal glial fibrillary acidic protein is inhibited by an isoform-specific C terminus. J Biol Chem. 2004;279:41537-45 pubmed
    The predominant isoform of glial fibrillary acidic protein (GFAP), GFAPalpha, is the characteristic building block of the cytoskeletal intermediate filaments in astrocytes...
  9. Blechingberg J, Lykke Andersen S, Jensen T, Jørgensen A, Nielsen A. Regulatory mechanisms for 3'-end alternative splicing and polyadenylation of the Glial Fibrillary Acidic Protein, GFAP, transcript. Nucleic Acids Res. 2007;35:7636-50 pubmed
    The glial fibrillary acidic protein, GFAP, forms the intermediate cytoskeleton in cells of the glial lineage...

More Information

Publications107 found, 100 shown here

  1. Brenner M, Johnson A, Boespflug Tanguy O, Rodriguez D, Goldman J, Messing A. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet. 2001;27:117-20 pubmed
    ..presence of Rosenthal fibers, cytoplasmic inclusions in astrocytes that contain the intermediate filament protein GFAP in association with small heat-shock proteins...
  2. Nielsen A, Holm I, Johansen M, Bonven B, Jørgensen P, Jørgensen A. A new splice variant of glial fibrillary acidic protein, GFAP epsilon, interacts with the presenilin proteins. J Biol Chem. 2002;277:29983-91 pubmed
    We describe a new human isoform, GFAP epsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein)...
  3. Der Perng M, Su M, Wen S, Li R, Gibbon T, Prescott A, et al. The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. Am J Hum Genet. 2006;79:197-213 pubmed
    ..quot;Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes...
  4. Chen Y, Lim S, Chen M, Quinlan R, Perng M. Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability. Exp Cell Res. 2011;317:2252-66 pubmed publisher
    ..disorder of astrocyte caused by dominant mutations in the astrocyte-specific intermediate filament glial fibrillary acidic protein (GFAP)...
  5. Hainfellner J, Voigtlander T, Strobel T, Mazal P, Maddalena A, Aguzzi A, et al. Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo. J Neuropathol Exp Neurol. 2001;60:449-61 pubmed
    Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells...
  6. Singh R, Nielsen A, Johansen M, Jørgensen A. Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAP. Genomics. 2003;82:185-93 pubmed
    Isoform GFAPepsilon of the human cytoskeletal protein GFAP carries, as the result of alternative splicing of exon 7a of GFAP, a novel 42-amino-acid-long C-terminal region with binding capacity for the presenilin proteins...
  7. Hol E, Roelofs R, Moraal E, Sonnemans M, Sluijs J, Proper E, et al. Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice forms. Mol Psychiatry. 2003;8:786-96 pubmed
    b>Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia. Here, we report on the expression of GFAP in neurons in the human hippocampus...
  8. Mouser P, Head E, Ha K, Rohn T. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol. 2006;168:936-46 pubmed
    ..occurs within glial cells in AD, we designed a site-directed caspase-cleavage antibody specific to glial fibrillary acidic protein (GFAP), a cytoskeleton protein specifically expressed in astrocytes...
  9. Bachetti T, Caroli F, Bocca P, Prigione I, Balbi P, Biancheri R, et al. Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease. Eur J Hum Genet. 2008;16:462-70 pubmed publisher
    ..containing cytoplasmic aggregates, called Rosenthal fibers, including the intermediate filament glial fibrillary acidic protein (GFAP)...
  10. Perng M, Wen S, Gibbon T, Middeldorp J, Sluijs J, Hol E, et al. Glial fibrillary acidic protein filaments can tolerate the incorporation of assembly-compromised GFAP-delta, but with consequences for filament organization and alphaB-crystallin association. Mol Biol Cell. 2008;19:4521-33 pubmed publisher
    The glial fibrillary acidic protein (GFAP) gene is alternatively spliced to give GFAP-alpha, the most abundant isoform, and seven other differentially expressed transcripts including GFAP-delta...
  11. van den Berge S, Middeldorp J, Zhang C, Curtis M, Leonard B, Mastroeni D, et al. Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta. Aging Cell. 2010;9:313-26 pubmed publisher
    ..the SVZ specifically expresses an assembly-compromised isoform of the intermediate filament protein glial fibrillary acidic protein (GFAP-delta)...
  12. Mondello S, Papa L, Buki A, Bullock M, Czeiter E, Tortella F, et al. Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit Care. 2011;15:R156 pubmed publisher
    ..the relationships among neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarker levels in serum, neuroradiological findings and outcomes after severe TBI...
  13. Cheng P, Lin Y, Chen Y, Lee Y, Tai C, Wang Y, et al. Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation. PLoS ONE. 2011;6:e22018 pubmed publisher
    ..differentiate into an astrocyte-like lineage, we revealed a novel role for Sin3A in maintaining the suppression of GFAP in NTera-2 cells...
  14. Kamphuis W, Middeldorp J, Kooijman L, Sluijs J, Kooi E, Moeton M, et al. Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease. Neurobiol Aging. 2014;35:492-510 pubmed publisher
    ..surrounded by reactive astrocytes with an increased expression of intermediate filaments including glial fibrillary acidic protein (GFAP)...
  15. Hagemann T, Boelens W, Wawrousek E, Messing A. Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet. 2009;18:1190-9 pubmed publisher
    ..disease (AxD) is a primary disorder of astrocytes caused by dominant mutations in the gene for glial fibrillary acidic protein (GFAP)...
  16. Martinian L, Boer K, Middeldorp J, Hol E, Sisodiya S, Squier W, et al. Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies. Neuropathol Appl Neurobiol. 2009;35:394-405 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP)-delta is a novel isoform that differs in its C-terminal sequence from other GFAP isoforms...
  17. Cabrera Galván J, Martínez Martin M, Déniz García D, Araujo Ruano E, Travieso Aja M. Adult-onset Alexander disease with a heterozygous D128N GFAP mutation: a pathological study. Histol Histopathol. 2019;:18110 pubmed publisher
    ..disease (AD) have been linked to heterozygous point mutations in the coding region of the HUMAN GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) gene...
  18. Casasnovas C, Verdura E, Vélez V, Schluter A, Pons Escoda A, Homedes C, et al. A novel mutation in the GFAP gene expands the phenotype of Alexander disease. J Med Genet. 2019;: pubmed publisher
    ..The novel variant in GFAP (Glial Fibrillary Acidic Protein) N-terminal head domain (p.Gly18Val) cosegregated in multiple relatives (LOD score: 2.7)...
  19. Yang Z, Wang K. Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker. Trends Neurosci. 2015;38:364-74 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found in astrocytes in the central nervous system (CNS), non-myelinating Schwann cells in the peripheral nervous system (PNS), and enteric glial ..
  20. Karp N, Lee D, Shickh S, Jenkins M. c.1289G>A (p.Arg430His) variant in the epsilon isoform of the GFAP gene in a patient with adult onset Alexander disease. Eur J Med Genet. 2019;62:235-238 pubmed publisher
    Alexander disease (AD) is a rare form of leukodystrophy caused by pathogenic variants in the GFAP gene. In young children the condition is fatal, while adults have variable neurological symptoms and prognosis...
  21. Matsumoto A, Tulyeu J, Furukawa R, Watanabe C, Monden Y, Nozaki Y, et al. A case of severe Alexander disease with de novo c. 239 T > C, p.(F80S), in GFAP. Brain Dev. 2018;40:587-591 pubmed publisher
    ..disease (AxD) is a progressive neurodegenerative disease caused by a mutation in the glial fibrillary acid protein (GFAP) gene...
  22. Liu Y, Zhou H, Wang H, Gong X, Zhou A, Zhao L, et al. Atypical MRI features in familial adult onset Alexander disease: case report. BMC Neurol. 2016;16:211 pubmed
    ..She and her daughter's glial fibrillary acidic protein (GFAP) gene analysis revealed the same heterozygous missense mutation, c.1246C?>?T, p...
  23. Bonthius D, Karacay B. Alexander Disease: A Novel Mutation in GFAP Leading to Epilepsia Partialis Continua. J Child Neurol. 2016;31:869-72 pubmed publisher
    Alexander disease is a genetically induced leukodystrophy, due to dominant mutations in the glial fibrillary acidic protein (GFAP ) gene, causing dysfunction of astrocytes...
  24. Brackmann F, Coras R, Rössler K, Kraus C, Rompel O, Trollmann R. Histopathological proof of the pathogenicity of a rare GFAP mutation in a patient with flaccid paraparesis. Brain Dev. 2018;40:330-333 pubmed publisher
    Infantile Alexander disease is a rare progressive leukodystrophy caused by autosomal dominant mutations in the (GFAP) gene typically presenting with psychomotor retardation, progressive macrocephaly and refractory epilepsy...
  25. Minkel H, Anwer T, Arps K, Brenner M, Olsen M. Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease. Glia. 2015;63:2285-97 pubmed publisher
    Alexander Disease (AxD) is a "gliopathy" caused by toxic, dominant gain-of-function mutations in the glial fibrillary acidic protein (GFAP) gene. Two distinct types of AxD exist...
  26. Peters T, Kim S, Castro V, Stingl K, Strasser T, Bolz S, et al. Evaluation of polyesteramide (PEA) and polyester (PLGA) microspheres as intravitreal drug delivery systems in albino rats. Biomaterials. 2017;124:157-168 pubmed publisher
    ..b>GFAP staining showed that Müller glia cell activation was most pronounced in PLGA-injected eyes...
  27. Wan J, Liu L, Zhang J, Lu J, Li Q. Promotion of neuronal regeneration by using self-polymerized dendritic polypeptide scaffold for spinal cord tissue engineering. J Mater Sci Mater Med. 2017;29:6 pubmed publisher
    ..Neural stem cells were showed anti Nestin (+), anti NSE (+), anti GFAP (+)...
  28. Keller B, García Sevilla J. Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:54-62 pubmed publisher
    ..5 fold) and increased GFAP (+57%) and nuclear PARP-1 fragmentation (+114%) 72h post-treatment (delayed neurotoxicity)...
  29. Ropper A, Zeng X, Anderson J, Yu D, Han I, Haragopal H, et al. An efficient device to experimentally model compression injury of mammalian spinal cord. Exp Neurol. 2015;271:515-23 pubmed publisher
    ..Immunocytochemical levels of glial fibrillary acidic protein (GFAP) and β-amyloid precursor protein (APP) at the cervical and lumbar regions were measured to ..
  30. Shen S, Duan C, Chen X, Wang Y, Sun X, Zhang Q, et al. Neurogenic effect of VEGF is related to increase of astrocytes transdifferentiation into new mature neurons in rat brains after stroke. Neuropharmacology. 2016;108:451-61 pubmed publisher
    ..The results showed that ischemic injury significantly increased glial fibrillary acidic protein immunopositive (GFAP(+)) and nestin(+) cells in ipsilateral striatum 3 days following MCAO...
  31. Wang L, Du Y, Wang K, Xu G, Luo S, He G. Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice. Exp Neurol. 2016;283:353-64 pubmed publisher
    ..CCH activated astrocytes, increased the co-expression of GFAP and AQP4, and destroyed the blood-brain barrier (BBB)...
  32. Ciechomska I, Przanowski P, Jackl J, Wojtas B, Kaminska B. BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells. Sci Rep. 2016;6:38723 pubmed publisher
    ..G9a binds to the promoters of autophagy (LC3B, WIPI1) and differentiation-related (GFAP, TUBB3) genes in GSCs...
  33. Zhang Z, Yuan H, Zhao H, Qi B, Li F, An L. PPAR? activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice. Int Immunopharmacol. 2017;43:53-61 pubmed publisher
    ..IL-6), interleukin-1?, ionized calcium-binding adaptor molecule-1 (IBA1)-positive cells, as well as glial fibrillary acidic protein (GFAP)-positive cells and brain-derived neurotrophic factor (BDNF), were measured...
  34. Motevasseli T, Daftarian N, Kanavi M, Ahmadieh H, Bagheri A, Hosseini S, et al. Ocular Safety of Intravitreal Connective Tissue Growth Factor Neutralizing Antibody. Curr Eye Res. 2017;42:1194-1201 pubmed publisher
    ..and the corresponding eyes were subjected to routine histopathology, immunohistochemistry for glial fibrillary acidic protein (GFAP), and terminal transferase dUTP nick end-labeling (TUNEL) assay...
  35. Koeppen A, Becker A, Qian J, Gelman B, Mazurkiewicz J. Friedreich Ataxia: Developmental Failure of the Dorsal Root Entry Zone. J Neuropathol Exp Neurol. 2017;76:969-977 pubmed publisher
    ..2 compound heterozygous FA patients were sectioned longitudinally to represent DREZ and stained for glial fibrillary acidic protein (GFAP), S100, vimentin, the central nervous system (CNS)-specific myelin protein proteolipid protein, ..
  36. Lundgaard I, Wang W, Eberhardt A, Vinitsky H, Reeves B, Peng S, et al. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Sci Rep. 2018;8:2246 pubmed publisher
    ..Chronic exposure to 1.5 g/kg ethanol increased GFAP expression and induced mislocation of the astrocyte-specific water channel aquaporin 4 (AQP4), but decreased the ..
  37. Cao Z, Wu X, Peng Y, Zhang R, Li N, Yang J, et al. Scorpion Venom Heat-Resistant Peptide Attenuates Glial Fibrillary Acidic Protein Expression via c-Jun/AP-1. Cell Mol Neurobiol. 2015;35:1073-9 pubmed publisher
    ..we found that SVHRP could inhibit the formation of a glial scar, which is characterized by enhanced glial fibrillary acidic protein (GFAP) expression, in the epileptic hippocampus...
  38. Palmfeldt J, Henningsen K, Eriksen S, Müller H, Wiborg O. Protein biomarkers of susceptibility and resilience to stress in a rat model of depression. Mol Cell Neurosci. 2016;74:87-95 pubmed publisher
    ..The regulated proteins corroborate previous studies on depression regulated proteins; including GFAP, HOMER1 and glutamatergic transmission (vesicular transporter 1, VGLUT1)...
  39. Koyuncuoglu T, Vızdıklar C, Üren D, Yilmaz H, Yıldırım Ç, Atal S, et al. Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure. Peptides. 2017;90:37-47 pubmed publisher
    ..Neuronal damage and increased GFAP immunoreactivity, observed in the hippocampal areas and cortex of PTZ-induced rats were alleviated in 3-day ..
  40. Nishikawa M, Mori H, Hara M. Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells. Environ Toxicol Pharmacol. 2017;53:81-88 pubmed publisher
    ..Downregulation of NSPC's marker (Nes) and upregulation of differentiated cell markers (Tubb3; neuron, Gfap; astrocyte) occurred simultaneously...
  41. Wang S, Guan S, Xu J, Li W, Ge D, Sun C, et al. Neural stem cell proliferation and differentiation in the conductive PEDOT-HA/Cs/Gel scaffold for neural tissue engineering. Biomater Sci. 2017;5:2024-2034 pubmed publisher
    ..but also enhanced NSC differentiation into neurons and astrocytes with up-regulated expression of ? tubulin-III and GFAP, respectively...
  42. Sarfo F, Owusu D, Adamu S, Awuah D, Appiah L, Amamoo M, et al. Plasma Glial Fibrillary Acidic Protein, Copeptin, and Matrix Metalloproteinase-9 Concentrations among West African Stroke Subjects Compared with Stroke-Free Controls. J Stroke Cerebrovasc Dis. 2018;27:633-644 pubmed publisher
    ..Plasma concentrations of glial fibrillary acidic protein (GFAP), copeptin, and matrix metalloproteinase-9 (MMP-9) among stroke patients and stroke-free ..
  43. O Loughlin E, Pakan J, Yilmazer Hanke D, McDermott K. Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala. J Neuroinflammation. 2017;14:212 pubmed publisher
    ..Morphological examination of cells expressing ionized calcium-binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) suggested long-term microglial activation and astrogliosis in postnatal amygdalar regions...
  44. Zhang P, Dai Y, Xiong J, Zhu S, Zhao M, Ding S, et al. iTRAQ-based differential proteomic analysis of the brains in a rat model of delayedcarbon monoxide encephalopathy. Brain Res Bull. 2018;137:329-337 pubmed publisher
    ..Three proteins, Glial fibrillary acidic protein (GFAP), mitochondrial malate dehydrogenase (MDHM), and isocitrate dehydrogenase [NAD] subunit alpha (..
  45. Norden D, Trojanowski P, Villanueva E, Navarro E, Godbout J. Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia. 2016;64:300-16 pubmed publisher
    ..Morphological alterations in microglia (Iba-1(+)) and astrocytes (GFAP(+)), however, were undetected during this 2-12 h timeframe...
  46. Loth M, Choi J, McGlothan J, Pletnikov M, Pomper M, Guilarte T. TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiol Dis. 2016;85:174-186 pubmed publisher
    ..Notably, TSPO colocalization with the astrocyte marker GFAP was greater than with the microglia marker, Mac-1...
  47. Finegersh A, Homanics G. Chromatin immunoprecipitation and gene expression analysis of neuronal subtypes after fluorescence activated cell sorting. J Neurosci Methods. 2016;263:81-8 pubmed publisher
    ..Isolated cells had enrichment of the dopamine 1 receptor (D1R) mRNA and nearly undetectable levels of GFAP and D2R mRNA...
  48. Chen X, Hao J, Fu T, Liu J, Yu M, He S, et al. Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats. Neurochem Res. 2016;41:2645-2654 pubmed
    ..Double immunofluorescence staining showed that LGR5 was co-expressed with glial fibrillary acidic protein (GFAP). Moreover, we detected that PCNA had colocalization with LGR5 and GFAP after SCI...
  49. Choi M, Ahn S, Yang E, Kim H, Chong Y, Kim H. Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus. Mol Brain. 2016;9:72 pubmed publisher
    ..Molecular changes also occur, such as an increase in the expression of glial fibrillary acidic protein (GFAP)...
  50. Mashima M, Chiba Y, Murakami R, Uemura N, Matsumoto K, Kawauchi M, et al. Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains. Neurosci Lett. 2017;636:90-94 pubmed publisher
    ..clear immunoreactivity for vimentin, while they were also colocalized with weak immunoreactivity for glial fibrillary acidic protein (GFAP) within the cytoplasm of some cells...
  51. Yamakawa G, Lengkeek C, Salberg S, Spanswick S, Mychasiuk R. Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats. PLoS ONE. 2017;12:e0187218 pubmed publisher
    ..Finally, modifications to expression of 12 genes (Adora2a, App, Aqp4, Bdnf, Bmal1, Clock, Cry, Gfap, Orx1, Orx2, Per, Tau), in the prefrontal cortex, hippocampus, and/or the hypothalamus were assessed...
  52. Radomska K, Halvardson J, Reinius B, Lindholm Carlström E, Emilsson L, Feuk L, et al. RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes. Hum Mol Genet. 2013;22:1373-82 pubmed publisher
    ..We found that an mRNA expression of Glial fibrillary acidic protein (GFAP), encoding a major component of astrocyte intermediate filaments, was down-regulated after QKI7 ..
  53. Hol E, Pekny M. Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. Curr Opin Cell Biol. 2015;32:121-30 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS)...
  54. Shimizu Y, Ito Y, Tanaka H, Ohshima T. Radial glial cell-specific ablation in the adult Zebrafish brain. Genesis. 2015;53:431-9 pubmed publisher
    ..We generated a Tg(gfap:Gal4FF) transgenic zebrafish line, which enabled us to express specific genes in RGCs...
  55. Popiolek Barczyk K, Kolosowska N, Piotrowska A, Makuch W, Rojewska E, Jurga A, et al. Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy. Neural Plast. 2015;2015:676473 pubmed publisher
    ..and hyperalgesia and increased the protein level of IBA1 (a microglial/macrophage marker) but did not change GFAP (an astrocyte marker) on day 7 after CCI...
  56. Tichy J, Spechtmeyer S, Mittelbronn M, Hattingen E, Rieger J, Senft C, et al. Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma. J Neurooncol. 2016;126:361-9 pubmed publisher
    ..b>Glial fibrillary acidic protein (GFAP) levels were determined from venous blood samples via a prototype ELISA assay prior to any ..
  57. Delcambre G, Liu J, Herrington J, Vallario K, Long M. Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue. Peerj. 2016;4:e1601 pubmed publisher
    ..mAb MAC387, Leica), NF-H(+) neurons (mAb NAP4, EnCor Biotechnology), microglia/macrophage (pAb Iba-1, Wako), and GFAP(+) astrocytes (mAb 5C10, EnCor Biotechnology)...
  58. Gyengesi E, Liang H, Millington C, Sonego S, Sirijovski D, Gunawardena D, et al. Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. Pharm Res. 2018;35:22 pubmed publisher
    To test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse...
  59. Michinaga S, Kimura A, Hatanaka S, Minami S, Asano A, Ikushima Y, et al. Delayed administration of BQ788, an ETB antagonist, after experimental traumatic brain injury promotes recovery of blood-brain barrier function and reduction of cerebral edema in mice. J Neurotrauma. 2018;: pubmed publisher
    ..observation of the cerebrum after FPI showed that ETB receptors are predominantly expressed in glial fibrillary acidic protein (GFAP)-positive astrocytes. BQ788 reduced FPI-induced increases in GFAP-positive astrocytes...
  60. Bell K, Funke S, Grus F. [Autoimmunity and glaucoma]. Ophthalmologe. 2019;116:18-27 pubmed publisher
    ..g., antibodies against 14-3-3 proteins, γ‑/α-synuclein, or also against glial fibrillary acidic protein (GFAP), show neuroprotective effects on retinal ganglion cells in vivo and in vitro...
  61. Wu H, Rodriguez A, Spur B, Venkataraman V. An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment. J Vis Exp. 2016;: pubmed publisher
    ..are assessed using three parameters: blood vessel leakage via IgG immunostaining, activation of Müller cells via GFAP staining and change in neuronal dendrites through staining for MAP2...
  62. Waller R, Woodroofe M, Wharton S, Ince P, Francese S, Heath P, et al. Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. J Neuroimmunol. 2016;299:139-146 pubmed publisher
    ..Astrocytes were isolated from control and NAWM by laser capture microdissection (LCM), using glial fibrillary acidic protein (GFAP) as a marker, and the astrocyte transcriptome determined using microarray analysis...
  63. Zhou J, Liu Q, Wang J, Guo X, Song L. [Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1255-9 pubmed
    To characterize the expressions of peroxiredoxin 1 (Prx1), peroxiredoxin 6 (Prx6) and glial fibrillary acidic protein (GFAP) in human brain astrocytoma and explore their clinical significance...
  64. Feneberg E, Steinacker P, Lehnert S, Böhm B, Mayer G, Otto M. Elevated glial fibrillary acidic protein levels in the cerebrospinal fluid of patients with narcolepsy. Sleep Med. 2013;14:692-4 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is an established indicator of astrogliosis. Therefore, variable cerebrospinal fluid (CSF) concentrations of this protein might reflect disease-specific pathologic profiles...
  65. Biasibetti R, Almeida Dos Santos J, Rodrigues L, Wartchow K, Suardi L, Nardin P, et al. Hippocampal changes in STZ-model of Alzheimer's disease are dependent on sex. Behav Brain Res. 2017;316:205-214 pubmed publisher
    ..cognitive deficit, cholinergic neurotransmission, glucose uptake, glutathione content and specific glial markers (GFAP and S100B protein) in the hippocampus of the rat...
  66. Torres Odio S, Key J, Hoepken H, Canet Pons J, Valek L, Roller B, et al. Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation. J Neuroinflammation. 2017;14:154 pubmed publisher
    ..Immunohistochemistry showed pronounced cellular response of Iba1-positive microglia and GFAP-positive astrocytes; brain lipidomics observed increases of ceramides as neuroinflammatory signs at old age...
  67. Ayuob N, Firgany A, El Mansy A, Ali S. Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?. Exp Mol Pathol. 2017;103:153-161 pubmed publisher
    ..Immunoexpression of surface makers of glial fibrillary acidic protein (GFAP), Ki67, Caspase-3, BDNF and GR in the hippocampus were estimated...
  68. Geller S, Lomet D, Caraty A, Tillet Y, Duittoz A, Vaudin P. Rostro-caudal maturation of glial cells in the accessory olfactory system during development: involvement in outgrowth of GnRH neurites. Eur J Neurosci. 2017;46:2596-2607 pubmed publisher
    ..However, during GnRH neurone migration, maturation of OEC to [GFAP+] state (glial fibrillary acid protein) was only observed in the nasal septum...
  69. Siebert C, Pierozan P, Kolling J, Dos Santos T, Sebotaio M, Marques E, et al. Vitamin D3 Reverses the Hippocampal Cytoskeleton Imbalance But Not Memory Deficits Caused by Ovariectomy in Adult Wistar Rats. Neuromolecular Med. 2017;19:345-356 pubmed publisher
    ..OVX altered hippocampal cytoskeleton phosphorylating system, evidenced by the hyperphosphorylation of glial fibrillary acidic protein (GFAP), low molecular weight neurofilament subunit (NFL), medium molecular weight neurofilament ..
  70. Mondello S, Sorinola A, Czeiter E, Vámos Z, Amrein K, Synnot A, et al. Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting with Mild Head Injury to Emergency Departments: A Living Systematic Review and Meta-Analysis. J Neurotrauma. 2017;: pubmed publisher
    ..and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI...
  71. Asahina N, Okamoto T, Sudo A, Kanazawa N, Tsujino S, Saitoh S. An infantile-juvenile form of Alexander disease caused by a R79H mutation in GFAP. Brain Dev. 2006;28:131-3 pubmed
    Alexander disease is a degenerative white matter disorder due to mutations in the glial fibrillary acidic protein (GFAP) gene...
  72. Lee T, Mane S, Eid T, Zhao H, Lin A, Guan Z, et al. Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med. 2007;13:1-13 pubmed
    ..pathways, which included the increased expression of genes associated with astrocyte structure (glial fibrillary acidic protein, ezrin-moesin-radixin, palladin), calcium regulation (S100 calcium binding protein beta, chemokine (C-..
  73. Storoni M, Verbeek M, Illes Z, Marignier R, Teunissen C, Grabowska M, et al. Serum GFAP levels in optic neuropathies. J Neurol Sci. 2012;317:117-22 pubmed publisher
    ..There is evidence for increased CSF glial fibrillary acidic protein (GFAP) and S100B levels in acute NMO...
  74. Thomsen R, Daugaard T, Holm I, Nielsen A. Alternative mRNA splicing from the glial fibrillary acidic protein (GFAP) gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes. PLoS ONE. 2013;8:e72110 pubmed publisher
    The intermediate filament network of astrocytes includes Glial fibrillary acidic protein (Gfap) as a major component...
  75. Peter F, Rost S, Rolfs A, Frech M. Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis. Orphanet J Rare Dis. 2017;12:145 pubmed publisher
    ..We determined the amount of reactive astrocytes and the regulation of the intermediate filaments GFAP and vimentin, all indicating gliosis...
  76. Jones M, Lebonville C, Paniccia J, Balentine M, Reissner K, Lysle D. Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β. Brain Behav Immun. 2018;67:355-363 pubmed publisher
    ..2 used triple fluorescence immunohistochemistry to examine hippocampal alterations in IL-1β, glial fibrillary acidic protein (GFAP), an astrocyte-specific marker, and ionized calcium binding adaptor molecule -1 (Iba-1), a ..
  77. Li S, Tu W, Zhong Y, Jiang X, Jiang S. [Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture Therapy for Neuropathic Pain]. Zhen Ci Yan Jiu. 2016;41:369-372 pubmed
    ..In regard to spinal astrocytes, acupuncture suppressed peripheral nerve injury induced activation of GFAP-labeled astrocytes, down-regulated the expression levels of macrophage inflammatory proteins (MIP)-1, MIP-1 ?, MIP-..
  78. Zhang Y, Zhu Z, Zhang D, Zhang Z, Ma B, Zhao S, et al. Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model. Exp Mol Med. 2017;49:e412 pubmed publisher
    ..and immunofluorescent staining was conducted to detect neurofilament protein 200 (NF-200) and glial fibrillary acidic protein (GFAP). The PTC1/PTC2-RNAi group displayed higher BBB scores than the SCI and NC groups...
  79. Nicchia G, Pisani F, Simone L, Cibelli A, Mola M, Dal Monte M, et al. Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina. Exp Eye Res. 2016;146:259-68 pubmed publisher
    ..and western blot, using the Müller cell marker Glutamine Synthetase (GS) and the astrocyte marker GFAP. While GS expression was not altered in AQP4 KO retinas, a strong GFAP upregulation was found at the level of AQP4 ..
  80. Yu H, Pan W, Zheng B, Wang H, Chen X, Liu Y, et al. Decreased proliferative, migrative and neuro-differentiative potential of postnatal rat enteric neural crest-derived cells during culture in vitro. Exp Cell Res. 2016;343:218-222 pubmed publisher
    ..Furthermore, the percentage of peripherin(+) cells decreased whilst the percentage of GFAP(+) cells increased with age...
  81. Lee Y, Wu S, Arinzeh T, Bunge M. Enhanced noradrenergic axon regeneration into schwann cell-filled PVDF-TrFE conduits after complete spinal cord transection. Biotechnol Bioeng. 2017;114:444-456 pubmed publisher
    ..b>Glial fibrillary acidic protein (GFAP)+ astrocyte processes and GFP (green fluorescent protein)-SCs were interdigitated at ..
  82. Kanazawa S, Nishizawa S, Takato T, Hoshi K. Biological roles of glial fibrillary acidic protein as a biomarker in cartilage regenerative medicine. J Cell Physiol. 2017;232:3182-3193 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is an intermediate filament that is expressed in specifically expressed auricular chondrocytes, which are good cell sources of cartilage regenerative medicine...
  83. Abdraboh M, Abdeen S, Salama M, Elhussiny M, El Sherbini Y, Eldeen N. Developmental neurotoxic effects of a low dose of TCE on 3D neurosphere system. Biochem Cell Biol. 2017;: pubmed publisher
    ..of TCE on inhibiting the NSCs differentiation which was confirmed by cell immunolabelling with astrocytes marker GFAP. TCE inhibitory effect on NSCs proliferation was estimated by the decrease at neurospheres diameter, ki67 ..
  84. Hopperton K, James N, Mohammad D, Irfan M, Bazinet R. Dietary fish oil, and to a lesser extent the fat-1 transgene, increases astrocyte activation in response to intracerebroventricular amyloid-? 1-40 in mice. Nutr Neurosci. 2017;:1-7 pubmed publisher
    Increases in astrocytes and one of their markers, glial fibrillary acidic protein (GFAP) have been reported in the brains of patients with Alzheimer's disease (AD)...
  85. Singh J, Sharma K, Pillai P. PDGFR inhibition mediated intracellular signalling in C6 glioma growth and migration: role of ERK and ROCK pathway. Cytotechnology. 2018;70:465-477 pubmed publisher
    ..PDGFR inhibition further regulates the C6 glioma tumor behaviour by inducing gene expression of GFAP, BDNF, and MECP2 and down regulating FAK expression...
  86. Chiu C, Yao N, Guo J, Shen C, Lee H, Chiu Y, et al. Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage. Oncotarget. 2017;8:94850-94861 pubmed publisher
    ..The glia cells accumulations were examined by GFAP and Iba1 immunohistochemistry, respectively...
  87. Brun M, Coles J, Monckton E, Glubrecht D, Bisgrove D, Godbout R. Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines. J Mol Biol. 2009;391:282-300 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP), an intermediate filament protein normally found in astrocytes, and the radial glial marker brain fatty acid-binding protein (B-FABP; also known as FABP7) are co-expressed in malignant glioma cell ..
  88. Valian N, Ahmadiani A, Dargahi L. Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra. J Cell Biochem. 2017;118:1369-1378 pubmed publisher
    ..Furthermore, we evaluated the glial fibrillary acidic protein (GFAP) and Iba1 mRNA levels, and the levels of tyrosine hydroxylase (TH) and ?-synuclein (?-syn) ..
  89. Koo E, Sheldon R, Lee B, Vexler Z, Ferriero D. Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. Pediatr Res. 2017;82:518-526 pubmed publisher
    ..ICC) staining for myelin basic protein (MBP), microglia (Iba1), and astrocytes (glia fibrillary acidic protein (GFAP)) was performed on adjacent sections...
  90. Li T, Vandesquille M, Bay S, Dhenain M, Delatour B, Lafaye P. Selection of similar single domain antibodies from two immune VHH libraries obtained from two alpacas by using different selection methods. Immunol Lett. 2017;188:89-95 pubmed publisher
    ..Three anti-GFAP (glial fibrillary acidic protein) VHHs were derived from an immune library obtained by ribosome display after immunization of one ..
  91. Hori Y, Gu X, Xie X, Kim S. Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med. 2005;2:e103 pubmed
  92. Carvalho R, da Silva Ferreira F, Heimfarth L, Pierozan P, Fernandes C, Pessoa Pureur R. Acute Hyperammonemia Induces NMDA-Mediated Hypophosphorylation of Intermediate Filaments Through PP1 and PP2B in Cerebral Cortex of Young Rats. Neurotox Res. 2016;30:138-49 pubmed publisher
    ..The injected ammonia altered the IF phosphorylation of astrocytes (GFAP and vimentin) and neurons (neurofilament subunits of low, middle, and high molecular weight, respectively: NFL, NFM,..