GEMIN4

Summary

Gene Symbol: GEMIN4
Description: gem nuclear organelle associated protein 4
Alias: HC56, HCAP1, HHRF-1, NEDMCR, p97, gem-associated protein 4, HCC-associated protein 1, component of gems 4, gemin-4
Species: human
Products:     GEMIN4

Top Publications

  1. Lorson M, Dickson A, Shaw D, Todd A, Young E, Morse R, et al. Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochem Biophys Res Commun. 2008;375:33-7 pubmed publisher
    b>Gemin4 is a ubiquitously expressed multifunctional protein that is involved in U snRNP assembly, apoptosis, nuclear/cytoplasmic transportation, transcription, and RNAi pathways...
  2. Sleeman J, Lamond A. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr Biol. 1999;9:1065-74 pubmed
    ..These include speckles, coiled bodies and nucleoli, in addition to a diffuse nucleoplasmic compartment. The reasons for snRNP accumulation in these different structures are unclear...
  3. Charroux B, Pellizzoni L, Perkinson R, Yong J, Shevchenko A, Mann M, et al. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol. 2000;148:1177-86 pubmed
    ..the identification by nanoelectrospray mass spectrometry of a novel component of the SMN complex that we name Gemin4. Gemin4 is associated in vivo with the SMN complex through a direct interaction with Gemin3...
  4. Meister G, Buhler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U. Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins. Hum Mol Genet. 2000;9:1977-86 pubmed
    ..protein 1 (SIP-1), the putative helicase dp103/Gemin3, the novel dp103/Gemin3-interacting protein GIP1/Gemin4 and three additional proteins with apparent masses of 43, 33 and 18 kDa, respectively...
  5. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G. Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. J Biol Chem. 2002;277:7540-5 pubmed
    ..The SMN complex is localized in both the cytoplasm and the nucleus and contains SMN, Gemin2, Gemin3, Gemin4, Gemin5, and a few not yet identified proteins...
  6. Gubitz A, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G. Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins. J Biol Chem. 2002;277:5631-6 pubmed
    ..SMN is part of a multi-protein complex that includes Gemin2, Gemin3, and Gemin4. The SMN complex plays an important role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs) ..
  7. Chari A, Golas M, Klingenhäger M, Neuenkirchen N, Sander B, Englbrecht C, et al. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell. 2008;135:497-509 pubmed publisher
    ..The mode of action of this combined chaperone/catalyst system is reminiscent of the mechanism employed by DNA clamp loaders. ..
  8. Horikawa Y, Wood C, Yang H, Zhao H, Ye Y, Gu J, et al. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res. 2008;14:7956-62 pubmed publisher
    ..polymorphisms (SNP) from 11 miRNA processing genes (DROSHA, DGCR8, XPO5, RAN, DICER1, TARBP2, AGO1, AGO2, GEMIN3, GEMIN4, HIWI) and 15 miRNA genes in 279 Caucasian patients with renal cell carcinoma and 278 matched controls...
  9. Yong J, Kasim M, Bachorik J, Wan L, Dreyfuss G. Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Mol Cell. 2010;38:551-62 pubmed publisher
    ..We propose a stepwise pathway of SMN complex formation and snRNP biogenesis, highlighting Gemin5's function in delivering pre-snRNAs as substrates for Sm core assembly and processing. ..

More Information

Publications115 found, 100 shown here

  1. Di Y, Li J, Zhang Y, He X, Lu H, Xu D, et al. HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. J Biochem. 2003;133:713-8 pubmed
    The gene HCAP1 (HCC-associated Protein 1), one variant of GEMIN4, has been mapped in a minimum LOH region on chromosome 17p13.3 and encodes a 1047-amino acid protein...
  2. Wan D, He M, Wang J, Qiu X, Zhou W, Luo Z, et al. Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B. Genes Chromosomes Cancer. 2004;39:48-58 pubmed
    ..Database searches revealed that HCAP1 shares most of its open reading frame with GEMIN4. Single nucleotide polymorphism (SNP) screening revealed a high incidence of SNP in the coding region of HCAP1 (12 ..
  3. Pellizzoni L, Baccon J, Charroux B, Dreyfuss G. The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr Biol. 2001;11:1079-88 pubmed
    ..SMN and its associated proteins Gemin2, Gemin3, and Gemin4 form a large complex that plays a role in snRNP assembly, pre-mRNA splicing, and transcription...
  4. Liu X, Zhang Y, Piao J, Mao D, Li Y, Li W, et al. Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010-2012. Nutrients. 2017;9: pubmed publisher
    ..Reference values were calculated covering the central 95% reference intervals (P2.5-P97.5) after excluding outliers by Dixon's test. The overall reference values of serum trace elements were 131.5 (55...
  5. Matera A, Raimer A, Schmidt C, Kelly J, Droby G, Baillat D, et al. Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster. G3 (Bethesda). 2019;9:491-503 pubmed publisher
    ..Bioinformatic comparisons show that CG2941 shares sequence and structural similarity with metazoan Gemin4. Additional analysis shows that three other genes (CG14164, CG31950 and CG2371) are not ..
  6. Brahms A, Mudhasani R, Pinkham C, Kota K, Nasar F, Zamani R, et al. Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway. J Virol. 2017;91: pubmed publisher
    ..b>p97/valosin-containing protein (VCP), which is involved in membrane remodeling in the secretory pathway and a known ..
  7. Wong H, Kumar P, Tay F, Moreau D, Liu D, Bard F. Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes. J Virol. 2015;89:11116-28 pubmed publisher
    ..In addition, our screen reveals an unexpected role for valosin-containing protein (VCP/p97) in early steps of infection...
  8. Wang N, Zhao J, He X, Sun H, Zhang G, Wu F. Comparative proteomic analysis of drought tolerance in the two contrasting Tibetan wild genotypes and cultivated genotype. BMC Genomics. 2015;16:432 pubmed publisher
    ..expressed or up-regulated under drought stress in XZ5 but not in XZ54, including melanoma-associated antigen p97, type I chlorophyll a/b-binding protein b, glutathione S-transferase 1, ribulosebisphosphate carboxylase large ..
  9. Stojsavljević A, Borković Mitić S, Vujotic L, Grujicic D, Gavrovic Jankulovic M, Manojlović D. The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population. Ecotoxicol Environ Saf. 2019;169:402-409 pubmed publisher
    ..5-P97.5). The obtained geometric mean (GM) for As, Cd, Pb, Th, and U were: 0.50 ng/g, 0.32 ng/g, 20.94 ng/g, 0...
  10. Jung K, Ko D, Shin N, Pyo C, Choi S. Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza A virus by regulating the host redox state. Free Radic Biol Med. 2019;135:293-305 pubmed publisher
    ..The increase in SOD1 levels with the expression of siRNA-targeting p97, a central component of the ubiquitin-proteasome system, supports the major role of the ERAD process in IAV-..
  11. Jarocki V, Santos J, Tacchi J, Raymond B, Deutscher A, Jenkins C, et al. MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae. Open Biol. 2015;5:140175 pubmed publisher
    ..M. hyopneumoniae recruits plasmin(ogen) onto its cell surface via the P97 and P102 adhesins and the glutamyl aminopeptidase MHJ_0125...
  12. McFarlane M, MacDonald A, Stevenson A, Graham S. Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35). J Virol. 2015;89:5276-87 pubmed publisher
    ..SRSF2 did not affect transcription from the P97 promoter that controls viral oncoprotein expression...
  13. Wang F, Olson E, Shyng S. Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels. J Biol Chem. 2012;287:10482-93 pubmed publisher
    ..We show that both SUR1 and Kir6.2 form a complex with Derlin-1 and an associated AAA-ATPase, p97. Overexpression of Derlin-1 led to a decrease in the biogenesis efficiency and surface expression of K(ATP) ..
  14. Delabaere L, Orsi G, Sapey Triomphe L, Horard B, Couble P, Loppin B. The Spartan ortholog maternal haploid is required for paternal chromosome integrity in the Drosophila zygote. Curr Biol. 2014;24:2281-7 pubmed publisher
    ..Like Spartan, MH protein is involved in the resistance to UV radiation and recruits the p97/TER94 segregase to stalled DNA replication forks in somatic cells...
  15. Sugiyama H, Takahashi K, Yamamoto T, Iwasaki M, Narita M, Nakamura M, et al. Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2017;114:340-345 pubmed publisher
    Novel APOBEC1 target 1 (Nat1) (also known as "p97," "Dap5," and "Eif4g2") is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal two thirds of eukaryotic translation initiation factor 4G (Eif4g1)...
  16. Cayli S, Ocakli S, Senel U, Eyerci N, Delibasi T. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. J Mol Histol. 2016;47:91-100 pubmed publisher
    ..Furthermore, Jab1/CSN5 expression was gradually upregulated and p97/VCP expression was downregulated in IR injury according to western blotting and immunohistochemistry...
  17. Volodin A, Kosti I, Goldberg A, Cohen S. Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A. 2017;114:E1375-E1384 pubmed publisher
    ..Down-regulation of PAX4 or its target gene encoding the p97/VCP ATPase reduced myofibril disassembly and degradation on denervation or fasting...
  18. Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, et al. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2015;112:E1135-42 pubmed publisher
    ..However, the p97 inhibitor eeyarestatin 1 enhanced immunotoxin killing...
  19. Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed publisher
    ..of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 and targets it for ubiquitin-, p97- and proteasome-mediated degradation to limit Ca2+ influx into mitochondria...
  20. Olmedo Carrillo P, Santiago Fernández P, Garcia Fuentes E, Ureña Fernández T, Gutiérrez Alcántara C, Sánchez Malo C, et al. Definition of reference ranges for free T4, TSH, and thyroglobulin levels in healthy subjects of the Jaén Health District. Endocrinol Diabetes Nutr. 2017;64:417-423 pubmed publisher
    ..59μg/L and 130.11μg/L respectively. Median TSH level was 1.83μIU/mL (p2.5=0.56μIU/mL, p97.5=4.66μIU/mL). Median FT4 level was 0.84ng/dL (p2.5=0.62ng/dL, p97.5=1.18ng/dL). TPO antibodies were detected in 5...
  21. Fu X, Adams Z, Liu R, Hepowit N, Wu Y, Bowmann C, et al. Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin-Like Protein Modification in Archaea. MBio. 2017;8: pubmed publisher
    ..protein remodeling, and oxidative stress and include the Ubl-modified MsrA, Orc3 (Orc1/Cdc6), and Cdc48d (Cdc48/p97 AAA+ ATPase)...
  22. Han D, Di X, Fu Y, Mu T. Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. J Biol Chem. 2015;290:325-37 pubmed publisher
    ..Presumably, valosin-containing protein (VCP)/p97 extracts misfolded subunits from the endoplasmic reticulum membrane to the cytosolic proteasome for degradation...
  23. Raymond B, Jenkins C, Seymour L, Tacchi J, Widjaja M, Jarocki V, et al. Proteolytic processing of the cilium adhesin MHJ_0194 (P123J ) in Mycoplasma hyopneumoniae generates a functionally diverse array of cleavage fragments that bind multiple host molecules. Cell Microbiol. 2015;17:425-44 pubmed publisher
    ..These extensive processing events are characterized here. The functional significance of the P97 cleavage fragments is also poorly understood...
  24. Okun J, Gan Schreier H, Ben Omran T, Schmidt K, Fang Hoffmann J, Gramer G, et al. Newborn Screening for Vitamin B6 Non-responsive Classical Homocystinuria: Systematical Evaluation of a Two-Tier Strategy. JIMD Rep. 2017;32:87-94 pubmed publisher
    ..In addition, dried blood spot samples selected by Met values >P97 in the newborn screening programs in Austria, Australia, the Netherlands, and Taiwan were analyzed for Hcy...
  25. Dos Santos L, Sreevatsan S, Torremorell M, Moreira M, Sibila M, Pieters M. Genotype distribution of Mycoplasma hyopneumoniae in swine herds from different geographical regions. Vet Microbiol. 2015;175:374-81 pubmed publisher
    ..The MLVA was standardized on the basis of the number of tandem repeats in two Mycoplasma adhesins, P97 and P146, which are proteins involved in the adherence of the pathogen to cilia...
  26. Tacchi J, Raymond B, Haynes P, Berry I, Widjaja M, Bogema D, et al. Post-translational processing targets functionally diverse proteins in Mycoplasma hyopneumoniae. Open Biol. 2016;6:150210 pubmed publisher
    ..The cell surface of M. hyopneumoniae is extensively modified by processing events that target the P97 and P102 adhesin families. Here, we present analyses of the proteome of M...
  27. Ma X, Liu H, Li J, Wang Y, Ding Y, Shen H, et al. Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis. Nat Commun. 2017;8:1941 pubmed publisher
    ..results in a reduced level of CRL4CDT2-dependent Polη polyubiquitination at lysine 462, a delayed p97-dependent removal of Polη from replication forks, and significantly enhanced UV-induced mutagenesis even though ..
  28. Khodayari N, Wang R, Marek G, Krotova K, Kirst M, Liu C, et al. SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78. PLoS ONE. 2017;12:e0172983 pubmed publisher
    ..of ZAAT is influenced by modulation of gp78 E3 ligase and SVIP (small VCP-interacting protein) interaction with p97/VCP in ZAAT-expressing hepatocytes...
  29. Jiang J, Tang C, Ren J, Zhang C, Dong L, Zhu Z. Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities. Pediatr neonatol. 2018;59:154-160 pubmed publisher
    ..The ability of learning and memory was assessed using the Morris water maze at P37 and P97. The hippocampal volume was measured by magnetic resonance imaging (MRI) at P37 and P97...
  30. Wang T, Xu W, Qin M, Yang Y, Bao P, Shen F, et al. Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. J Biol Chem. 2016;291:14373-84 pubmed publisher
    Valosin-containing protein/p97(VCP) is a hexameric ATPase vital to protein degradation during endoplasmic reticulum stress. It regulates diverse cellular functions including autophagy, chromatin remodeling, and DNA repair...
  31. Tao S, Tillotson J, Wijeratne E, Xu Y, Kang M, Wu T, et al. Withaferin A Analogs That Target the AAA+ Chaperone p97. ACS Chem Biol. 2015;10:1916-1924 pubmed publisher
    ..We now show that WFA acts as an inhibitor of the chaperone, p97, both in vitro and in cell models in addition to inhibiting the proteasome in vitro...
  32. Nie M, Boddy M. Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability. Biomolecules. 2016;6:14 pubmed publisher
    ..These mixed SUMO-ubiquitin chains recruit "effector" proteins such as the AAA⁺ ATPase Cdc48/p97-Ufd1-Npl4 complex that contain both ubiquitin and SUMO interaction motifs...
  33. He J, Zhu Q, Wani G, Sharma N, Wani A. Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin. J Biol Chem. 2016;291:7396-408 pubmed publisher
    ..Here we demonstrate that valosin-containing protein (VCP)/p97 segregase functions in ultraviolet radiation (UVR)-induced ubiquitin-mediated CSB degradation...
  34. Na H, Song G. Predicting the functional motions of p97 using symmetric normal modes. Proteins. 2016;84:1823-1835 pubmed publisher
    b>p97 is a protein complex of the AAA+ family. Although functions of p97 are well understood, the mechanism by which p97 performs its unfolding activities remains unclear...
  35. McEwan W, Falcon B, Vaysburd M, Clift D, Oblak A, Ghetti B, et al. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proc Natl Acad Sci U S A. 2017;114:574-579 pubmed publisher
    ..After binding, TRIM21 neutralizes tau seeds through the activity of the proteasome and the AAA ATPase p97/VCP in a similar manner to infectious viruses...
  36. Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, et al. Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. Cell Rep. 2015;13:944-56 pubmed publisher
    ..Moreover, the cytosolic chaperone Bag6 and the AAA-ATPase p97 contribute to the degradation of ER pQC substrates...
  37. Bègue H, Jeandroz S, Blanchard C, Wendehenne D, Rosnoblet C. Structure and functions of the chaperone-like p97/CDC48 in plants. Biochim Biophys Acta Gen Subj. 2017;1861:3053-3060 pubmed publisher
    The chaperone-like p97 is a member of the AAA+ ATPase enzyme family that contributes to numerous cellular activities...
  38. Patel N, Anand D, Monies D, Maddirevula S, Khan A, Algoufi T, et al. Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract. Hum Genet. 2017;136:205-225 pubmed publisher
    ..b>GEMIN4 was independently mutated in families with a syndrome of cataract, global developmental delay with or without ..
  39. Wargachuk R, Glazkova I, Audet N, Pétrin D, Trieu P, Hebert T. VCP/p97 regulates ?2AR quality control during receptor biosynthesis. Cell Signal. 2017;30:50-58 pubmed publisher
    ..Degradation (ERAD) quality control system [1], including the valosin-containing protein (VCP/p97)...
  40. Song C, Wang Q, Song C, Rogers T. Valosin-containing protein (VCP/p97) is capable of unfolding polyubiquitinated proteins through its ATPase domains. Biochem Biophys Res Commun. 2015;463:453-7 pubmed publisher
    Valosin-containing protein (VCP or p97) is required for the proteasomal degradation of polyubiquitinated proteins. However, the molecular mechanism for VCP to process the polyubiquitinated proteins remains unclear...
  41. Nabhan J, Gooch R, Piatnitski Chekler E, Pierce B, Bulawa C. Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin. Sci Rep. 2015;5:18251 pubmed publisher
    ..We targeted p97/VCP, the ubiquitin proteasome pathway (UPP), and autophagy with chemical inhibitors in cell lines and patient-..
  42. Tang W, Xia D. Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain. Sci Rep. 2016;6:20037 pubmed publisher
    Human AAA(+) protein p97 consists of an N-domain and two tandem ATPase domains D1 and D2, which are connected by the N-D1 and the D1-D2 linkers...
  43. de Arriba Muñoz A, López Úbeda M, Rueda Caballero C, Labarta Aizpún J, Ferrandez Longás A. [Not Available]. Nutr Hosp. 2016;33:388 pubmed publisher
    ..Se calcularon los percentiles (P3, P10, P25, P50, P75, P90, P97) de IMC y PA según edad y sexo...
  44. Gugliotta G, Sudo M, Cao Q, Lin D, Sun H, Takao S, et al. Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia. Neoplasia. 2017;19:750-761 pubmed publisher
    ..Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma...
  45. Hiraishi N, Ishida Y, Nagahama M. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Biochem Biophys Res Commun. 2015;467:534-40 pubmed publisher
    ..activities) family, which exhibits a high level of amino acid sequence similarity with the cytosolic AAA-ATPase VCP/p97. These proteins generally act on macromolecular complexes to stimulate energy-dependent release of their ..
  46. Fu X, Liu R, Sanchez I, Silva Sanchez C, Hepowit N, Cao S, et al. Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea. MBio. 2016;7: pubmed publisher
    ..Rapid turnover of TBP2 required the functions of UbaA (the E1/MoeB/ThiF homolog of archaea), AAA ATPases (Cdc48/p97 and Rpt types), a type 2 JAB1/MPN/MOV34 metalloenzyme (JAMM/MPN+) homolog (JAMM2), and 20S proteasomes...
  47. Tiwari A, Copeland C, Han B, Hanson C, Raghunathan K, Kenworthy A. Caveolin-1 is an aggresome-inducing protein. Sci Rep. 2016;6:38681 pubmed publisher
    ..manner, and are enriched in a number of key regulators of protein turnover, including ubiquitin, VCP/p97 and proteasomes...
  48. Loayza D, Tam A, Schmidt W, Michaelis S. Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae. Mol Biol Cell. 1998;9:2767-84 pubmed
    ..suppressors of the mating defect of one of the ER-retained ste6 mutants has identified a proteasome subunit, Hrd2p/p97, previously implicated in the regulated degradation of wild-type hydroxymethylglutaryl-CoA reductase in the ER ..
  49. Zhang Y, Li W, Chu M, Chen H, Yu H, Fang C, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016;181:329-39 pubmed publisher
    ..Furthermore, DBeQ, an inhibitor of the AAA ATPase p97, was shown to inhibit the ATPase activity of Vps4 with an IC50 of about 11.5 μM...
  50. Steffen J, Vashisht A, Wan J, Jen J, Claypool S, Wohlschlegel J, et al. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. Mol Biol Cell. 2017;28:600-612 pubmed publisher
    ..MULAN and MARCH5 coordinate ubiquitylation of SLC25A46 L341P, leading to degradation by organized activities of P97 and the proteasome...
  51. Byun H, Das P, Yu H, Alemán A, Lozano M, Matouschek A, et al. Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation. MBio. 2017;8: pubmed publisher
    ..trap (UBAIT) screen to trap and identify transient protein interactions with SP, including the ERAD-associated p97 ATPase, but not E3 ligases or Derlin proteins linked to retrotranslocation, polyubiquitylation, and proteasomal ..
  52. Papadopoulos C, Meyer H. Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy. Curr Biol. 2017;27:R1330-R1341 pubmed publisher
    ..is ensured by additional layers of regulation, including modulation by the ubiquitin-directed AAA-ATPase VCP/p97. Lysophagy shares many features with mitophagy, the macroautophagic removal of damaged mitochondria...
  53. Bukhari S, Truesdell S, Lee S, Kollu S, Classon A, Boukhali M, et al. A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence. Mol Cell. 2016;61:760-773 pubmed publisher
    ..Consistently, inhibition of PARN deadenylase prevents activation. P97/DAP5, a homolog of canonical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting ..
  54. Fullbright G, Rycenga H, Gruber J, Long D. p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair. Mol Cell Biol. 2016;36:2983-2994 pubmed publisher
    ..Here we report that the p97/Cdc48/VCP segregase plays a critical role in ICL repair by unloading the CMG complex from chromatin...
  55. Avci D, Lemberg M. Clipping or Extracting: Two Ways to Membrane Protein Degradation. Trends Cell Biol. 2015;25:611-22 pubmed publisher
    ..While most of our understanding of this mechanism comes from studies on p97/Cdc48-mediated protein dislocation along the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, ..
  56. Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, et al. VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017;36:135-150 pubmed publisher
    ..Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy...
  57. Alpizar M, Peschard V, Escalante Araiza F, Altamirano Bustamante N, Murata C, Arenas Pérez R, et al. Smoothed Body Composition Percentiles Curves for Mexican Children Aged 6 to 12 Years. Children (Basel). 2017;4: pubmed publisher
    ..FMI values peaked in boys at age 12 (P97 = 14.1 kg/m²) and in girls at age 11 (P97 = 8.8 kg/m²)...
  58. Xia D, Tang W, Ye Y. Structure and function of the AAA+ ATPase p97/Cdc48p. Gene. 2016;583:64-77 pubmed publisher
    b>p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes and archaebacteria...
  59. Gendron J, Webb K, Yang B, Rising L, Zuzow N, Bennett E. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction. Mol Cell Proteomics. 2016;15:2576-93 pubmed publisher
    ..Using a recently developed potent inhibitor of the critical protein homeostasis factor p97/VCP, we demonstrate that distinct insults to protein homeostasis function can elicit robust and largely unique ..
  60. Forget P, Khalifa C, Defour J, Latinne D, Van Pel M, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio?. BMC Res Notes. 2017;10:12 pubmed publisher
    ..5 and P97.5. A second independent sample of healthy volunteers is compared (n = 29). The mean NLR is 1.65 [±1.96 SD: 0...
  61. Hänzelmann P, Schindelin H. Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97. Structure. 2016;24:127-139 pubmed publisher
    b>p97 belongs to the superfamily of AAA+ ATPases and is characterized by a tandem AAA module, an N-terminal domain involved in substrate and cofactor interactions, and a functionally important unstructured C-terminal tail...
  62. Piazzon N, Schlotter F, Lefebvre S, Dodré M, Mereau A, Soret J, et al. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nucleic Acids Res. 2013;41:1255-72 pubmed publisher
    ..Our data show that reduced levels of the SMN protein lead to defect in SRP steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis. ..
  63. Han K, Foster D, Harhaj E, Dzieciatkowska M, Hansen K, Liu C. Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity. Hum Mol Genet. 2016;25:1392-405 pubmed publisher
    ..Moreover, mislocalization of SMN disrupts CB integrity and likely impairs snRNP maturation. ..
  64. Chen L, Shi H, Yuan J, Bowness P. Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression. Ann Rheum Dis. 2017;76:593-601 pubmed publisher
    Association of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has recently been reported...
  65. Frattini C, Villa Hernández S, Pellicanò G, Jossen R, Katou Y, Shirahige K, et al. Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics. Mol Cell. 2017;68:758-772.e4 pubmed publisher
    ..promotes cohesin mobilization from chromatin neighboring stalled forks, likely by stimulating the Cdc48/p97 ubiquitin-selective segregase, and its timely association to nascent chromatids...
  66. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G. Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. J Biol Chem. 2002;277:31957-62 pubmed
    ..SMN is part of a large macromolecular complex that also contains Gemin2, Gemin3, Gemin4, Gemin5, and Gemin6...
  67. Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P, Voinnet O. Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 2012;14:1314-21 pubmed
    ..These findings have implications for human diseases linked to misregulated autophagy, DICER- and miRNA-levels, including cancer. ..
  68. Rennella E, Schuetz A, Kay L. Quantitative measurement of exchange dynamics in proteins via (13)C relaxation dispersion of (13)CHD2-labeled samples. J Biomol NMR. 2016;65:59-64 pubmed publisher
    ..The utility of the approach is established with a number of applications, including measurement of ms dynamics of a disease mutant of a 320 kDa p97 complex.
  69. Blythe E, Olson K, Chau V, Deshaies R. Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy. Proc Natl Acad Sci U S A. 2017;114:E4380-E4388 pubmed publisher
    b>p97 is a "segregase" that plays a key role in numerous ubiquitin (Ub)-dependent pathways such as ER-associated degradation...
  70. Boni V, Zarate R, Villa J, Bandres E, Gomez M, Maiello E, et al. Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan. Pharmacogenomics J. 2011;11:429-36 pubmed publisher
    ..Our results suggest that miRNA polymorphic variants might be useful predictors of clinical outcome in mCRC patients treated with 5-fluorouracil and CPT-11 combination. ..
  71. Greenblatt M, Park K, Oh H, Kim J, Shin D, Lee J, et al. CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 2015;212:1283-301 pubmed publisher
    ..analysis demonstrated that CHMP5 cooperates with the PDB genetic risk factor valosin-containing protein (VCP/p97) to stabilize the inhibitor of NF-κBα (IκBα), down-regulating ubiquitination of IκBα via the ..
  72. Li Z, Wang Y, Xu M, Jiang T. Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. Biochem Biophys Res Commun. 2017;486:94-100 pubmed publisher
    In humans, UBXD7 (also called UBXN7), an adaptor of p97 ATPase, can participate in the degradation of misfolded or damaged proteins in the p97-mediated ubiquitin proteasome system (UPS)...
  73. van den Boom J, Meyer H. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69:182-194 pubmed publisher
    The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes reaching from degradation of damaged proteins and organelles to key signaling events and chromatin regulation with thousands of client proteins...
  74. Meyer H. Golgi reassembly after mitosis: the AAA family meets the ubiquitin family. Biochim Biophys Acta. 2005;1744:481-92 pubmed
    ..Two AAA ATPases, NSF and p97/VCP, have been implicated in regulating membrane fusion steps that lead to regrowth of Golgi cisternae from mitotic ..
  75. Yang J, Fuller P, Morgan J, Shibata H, Clyne C, Young M. GEMIN4 functions as a coregulator of the mineralocorticoid receptor. J Mol Endocrinol. 2015;54:149-60 pubmed publisher
    ..Gem (nuclear organelle)-associated protein 4 (GEMIN4) is one of the proteins that contain this motif...
  76. Dasari V, Rehan S, Tey S, Smyth M, Smith C, Khanna R. Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells. Immunol Cell Biol. 2016;94:964-974 pubmed publisher
    ..Interestingly, this cross-presentation was critically dependent on valosin-containing protein (VCP)/p97 ATPase through its participation in autophagy...
  77. Fang X, Yin Z, Li X, Xia L, Zhou B. Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and ..
  78. Skrott Z, Mistrik M, Andersen K, Friis S, Majera D, Gursky J, et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017;552:194-199 pubmed publisher
    ..biophysical analyses reveal the molecular target of disulfiram's tumour-suppressing effects as NPL4, an adaptor of p97 (also known as VCP) segregase, which is essential for the turnover of proteins involved in multiple regulatory and ..
  79. Park J, Voss P, Grabski S, Wang J, Patterson R. Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res. 2001;29:3595-602 pubmed
    ..Using a yeast two-hybrid screen with galectin-1 as bait, Gemin4 was identified as a putative interacting protein...
  80. Qin W, Wan F, Sun F, Zhang P, Han L, Huang Y, et al. Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma. Cell Res. 2001;11:209-16 pubmed
    ..The above results indicate that C17orf25 is a novel human gene, and the cloning and preliminary characterization of C17orf25 is a prerequisite for further functional analysis of this novel gene in human hepatocellular carcinoma. ..
  81. Clague J, Lippman S, Yang H, Hildebrandt M, Ye Y, Lee J, et al. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog. 2010;49:183-9 pubmed publisher
  82. Schneider S, Pei Y, Shuman S, Schwer B. Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD. Mol Cell Biol. 2010;30:2353-64 pubmed publisher
    ..Viability of yeast cells bearing both Spt5 CTD T1A and Pol II CTD S2A mutations heralds that the Cdk9 kinase has an essential target other than Spt5 and Pol II CTD-Ser2. ..
  83. Lin J, Horikawa Y, Tamboli P, Clague J, Wood C, Wu X. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. Carcinogenesis. 2010;31:1805-12 pubmed publisher
    ..The most significant associations were SNPs in GEMIN4 with the variant alleles of both rs7813 and rs910925 associated with 1.74-fold [95% confidence interval (CI) = 1...
  84. Huang S, Tang D, Wang Y. Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle. Dev Cell. 2016;38:73-85 pubmed publisher
    ..the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97. Expression of the Syn5 K270R mutant in cells impairs post-mitotic Golgi reassembly...
  85. Rao M, Williams D, Cocklin S, Loll P. Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding. J Biol Chem. 2017;292:18392-18407 pubmed publisher
    b>p97 is an essential ATPase associated with various cellular activities (AAA+) that functions as a segregase in diverse cellular processes, including the maintenance of proteostasis...
  86. Lanfranco M, Cacciottolo R, Borg R, Vassallo N, Juge F, Bordonné R, et al. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. FEBS Lett. 2017;591:3600-3614 pubmed publisher
    ..methods, we have identified novel interacting partners of the Drosophila SMN complex with homologies to Gemin4/6/7/8. The Gemin4 and Gemin8 orthologues are required for neuromuscular function and survival...
  87. Carnegie G, Sleeman J, Morrice N, Hastie C, Peggie M, Philp A, et al. Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs. J Cell Sci. 2003;116:1905-13 pubmed
    ..that specifically co-purify with Flag-epitope-tagged R2 expressed in HEK-293 cells were identified as Gemin3 and Gemin4. These two proteins have been identified previously as components of the Survival of Motor Neurons (SMN) protein ..
  88. Liu J, Liu J, Wei M, He Y, Liao B, Liao G, et al. Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population. DNA Cell Biol. 2012;31:1296-302 pubmed publisher
    ..study was intended to identify common genetic variants responsible for prostate cancer susceptibility in the GEMIN4 gene...
  89. Nakamura N, Harada K, Kato M, Hirose S. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6. Exp Cell Res. 2014;328:207-16 pubmed publisher
    ..In particular, USP19 was found to protect MARCH6 by deubiquitination from the p97-dependent proteasomal degradation...
  90. Wang C, Dong H, Fan H, Wu J, Wang G. Genetic polymorphisms of microRNA machinery genes predict overall survival of esophageal squamous carcinoma. J Clin Lab Anal. 2017;: pubmed publisher
    ..processing machinery genes, including Dicer (rs3742330), RAN (rs14035), XPO5 (rs11077), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), were evaluated for their association with esophageal squamous cell carcinoma (ESCC).
  91. Wilker E, Baccarelli A, Suh H, Vokonas P, Wright R, Schwartz J. Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes. Environ Health Perspect. 2010;118:943-8 pubmed publisher
    ..88-2.67). Interactions modifying BC associations were observed with SNPs in the DICER, GEMIN4, and DiGeorge critical region-8 (DGCR8) genes, and in GEMIN3 and GEMIN4, predicting diastolic and systolic BP, ..
  92. Han K, Foster D, Zhang N, Kanisha K, Dzieciatkowska M, Sclafani R, et al. Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron. J Biol Chem. 2012;287:43741-52 pubmed publisher
    ..Together, our results indicate that SMN and SMNΔ7 are differently ubiquitinated; Usp9x plays an important role in stabilizing SMN and the SMN complex, likely via antagonizing Ub-dependent SMN degradation. ..