Gene Symbol: GBP2
Description: guanylate binding protein 2
Alias: guanylate-binding protein 2, GTP-binding protein 2, guanine nucleotide-binding protein 2, guanylate binding protein 2, interferon-inducible, interferon-induced guanylate-binding protein 2
Species: human
Products:     GBP2

Top Publications

  1. Vestal D, Gorbacheva V, Sen G. Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?. J Interferon Cytokine Res. 2000;20:991-1000 pubmed
    ..The different intracellular distribution of these two closely related family members suggests differential function(s). ..
  2. Tripal P, Bauer M, Naschberger E, Mörtinger T, Hohenadl C, Cornali E, et al. Unique features of different members of the human guanylate-binding protein family. J Interferon Cytokine Res. 2007;27:44-52 pubmed
    ..These results assign a characteristic pattern of expression and subcellular localization to each of the HuGBPs, indicating for the first time that these proteins may have different cellular functions. ..
  3. Kotov D, Mitchell J, Pengo T, Ruedl C, Way S, Langlois R, et al. TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2. J Immunol. 2019;202:2535-2545 pubmed publisher
    ..T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells...
  4. Mastronardi C, Paz Filho G, Zanoni M, Molano González N, Arcos Burgos M, Licinio J, et al. Temporal gene expression in the hippocampus and peripheral organs to endotoxin-induced systemic inflammatory response in caspase-1-deficient mice. Neuroimmunomodulation. 2015;22:263-73 pubmed publisher
    ..synthase 2, two inducible enzymes), Cxcl1 and Cxcl10 (C-X-C motif chemokine ligand 1 and ligand 10), Tgtp and Gbp2 (T cell-specific GTPase 1 and guanylate-binding protein 2, two GTPases), Adamts1 (a disintegrin-like and ..
  5. do Nascimento N, Guimaraes A, Dos Santos A, Chu Y, Marques L, Messick J. RNA-Seq based transcriptome of whole blood from immunocompetent pigs (Sus scrofa) experimentally infected with Mycoplasma suis strain Illinois. Vet Res. 2018;49:49 pubmed publisher
    ..innate immunity (tlr8, chemokines, chemokines receptors) and genes containing IFN gamma-activated sequence (gbp1, gbp2, il15, cxcl10, casp1, cd274) suggests a general suppression of the immune response in the infected animals...
  6. Meunier E, Wallet P, Dreier R, Costanzo S, Anton L, Rühl S, et al. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol. 2015;16:476-484 pubmed publisher
    ..genes (ISGs) through the use of small interfering RNA (siRNA), we identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida...
  7. Cao X, Huang Y, Ma Y, Cheng J, Qu Z, Ma Y, et al. Integrating CNVs into meta-QTL identified GBP4 as positional candidate for adult cattle stature. Funct Integr Genomics. 2018;18:559-567 pubmed publisher
    ..Although higher copy number downregulated the mRNA levels of GBP2 (P < 0.05) and GBP4 (P < 0.05) in 1-Mb window (54.0-55...
  8. Mori G, Sasaki H, Makabe Y, Yoshinari M, Yajima Y. The genes Scgb1a1, Lpo and Gbp2 characteristically expressed in peri-implant epithelium of rats. Clin Oral Implants Res. 2016;27:e190-e198 pubmed publisher
    ..Genes Scgb1a1 were significantly upregulated more than 19.1-fold, Lpo more than 19.0-fold, and Gbp2 more than 8.9-fold, in the PIE (P < 0.01)...
  9. Liang H, Kerschen E, Hernandez I, Basu S, Zogg M, Botros F, et al. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015;125:2845-54 pubmed publisher fully initiate an interferon-regulated gene expression program that included the Irf8 target genes Lif, Iigp1, Gbp2, Gbp3, and Gbp6...

More Information


  1. Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, et al. mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature. 2016;540:593-596 pubmed publisher
    ..In Saccharomyces cerevisiae, the shuttling RNA adaptor proteins Npl3, Gbp2, Hrb1 and Nab2 are loaded co-transcriptionally onto growing pre-mRNAs...
  2. Feeley E, Pilla Moffett D, Zwack E, Piro A, Finethy R, Kolb J, et al. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017;114:E1698-E1706 pubmed publisher
    ..We report that the delivery of GBP2 to Legionella-containing vacuoles is dependent on the bacterial Dot/Icm secretion system, whereas the ..
  3. Koyama T, Mirth C. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. PLoS Biol. 2016;14:e1002392 pubmed publisher
    ..Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling...
  4. Zhang G, Zheng L, He H, Song C, Zhang Z, Cao X, et al. Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle. Gene. 2018;647:101-106 pubmed publisher
    ..The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation...
  5. Wang X, Wang S, Zhou L, Yu L, Zhang L. A network-pathway based module identification for predicting the prognosis of ovarian cancer patients. J Ovarian Res. 2016;9:73 pubmed
    ..interaction modules (31: DCLRE1A, EXO1, KIAA0101, KIN, PCNA, POLD3, POLD2; 35: DKK3, FABP3, IRF1, AIM2, GBP1, GBP2, IRF2) that are associated with prognosis of ovarian cancer patients...
  6. De Ron P, Dremier S, Winlow P, Jenkins A, Hanon E, Nogueira da Costa A. Correlating behaviour and gene expression endpoints in the dopaminergic system after modafinil administration in mouse. Eur Neuropsychopharmacol. 2016;26:729-40 pubmed publisher
    ..a concomitant effect on CPP, locomotor activity, and up-regulation of interferon-γ (IFN-γ) regulated genes (Gbp2, Gbp3, Gbp10, Cd274, Igtp), while correlating the latter set of genes with behaviour changes evaluated through the ..
  7. Miao Q, Ge M, Huang L. Up-regulation of GBP2 is Associated with Neuronal Apoptosis in Rat Brain Cortex Following Traumatic Brain Injury. Neurochem Res. 2017;42:1515-1523 pubmed publisher
    b>Guanylate binding protein 2 (GBP2) is one member of GBP family. Recently, GBP2 has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in the traumatic brain injury (TBI) is very limited...
  8. Ohshima J, Sasai M, Liu J, Yamashita K, Ma J, Lee Y, et al. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci U S A. 2015;112:E4581-90 pubmed publisher
    ..Among members of IRGs and GBPs important for the parasite clearance, Irga6 and Gbp2 alone were more frequently recruited to T. gondii-forming parasitophorous vacuoles in RabGDIα-deficient cells...
  9. Martínez Lumbreras S, Taverniti V, Zorrilla S, Séraphin B, Pérez Cañadillas J. Gbp2 interacts with THO/TREX through a novel type of RRM domain. Nucleic Acids Res. 2016;44:437-48 pubmed publisher
    ..We determined the NMR structures and nucleic acid interaction modes of Gbp2 and Hrb1, two paralogous budding yeast proteins with similarities to mammalian SR proteins...
  10. Lozano Pope I, Sharma A, Matthias M, Doran K, Obonyo M. Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer. BMC Cancer. 2017;17:133 pubmed publisher
    ..felis-infected Myd88 -/- mice included, Indoleamine 2,3-Dioxygenase 1 (Ido1), Guanylate binding protein 2 (Gbp2), ubiquitin D (Ubd), ? 2 -Microglobulin (B2m), CD74 antigen (Cd74), which have been ..
  11. Encheva V, Foltz C, Snijders A, Frickel E. Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection. BMC Res Notes. 2018;11:166 pubmed publisher
    ..Nevertheless, we identified and confirmed Gbp1 and Gbp2 as being ubiquitinated in a Toxoplasma-infection independent manner.
  12. Finethy R, Luoma S, Orench Rivera N, Feeley E, Haldar A, Yamamoto M, et al. Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. MBio. 2017;8: pubmed publisher
    ..In agreement with our observations from in vivo experiments, we demonstrate that macrophages lacking GBP2 expression fail to induce pyroptotic cell death and proinflammatory interleukin-1? (IL-1?) and IL-18 secretion when ..
  13. Christian S, Zu D, Licursi M, Komatsu Y, Pongnopparat T, Codner D, et al. Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. PLoS ONE. 2012;7:e44267 pubmed publisher
    ..Furthermore, the expression of a distinct subset of IFN inducible genes, that included RIGI, GBP2, IFIT2, BTN3A3, MAP2, MMP7 and STAT2, was restored or increased in HT1080 cells when the cells were co-treated with ..
  14. Zhang S, Feng T, Ning Y, Zhang X, Qi C. [Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1153-1159 pubmed
    Objective To investigate the effect of guanylate-binding protein 2 (GBP2) on β-glucan-induced maturation and immune response of dendritic cells (DCs)...
  15. King J, Yeh S, Lin M, Liu C, Lai M, Kao J, et al. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. Hepatology. 2002;36:1416-24 pubmed
    ..These observations may help guide future large-scale studies in examining host SNPs for their clinical utility in predicting IFN response. ..
  16. Cheng Y, Patterson C, Staeheli P. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol. 1991;11:4717-25 pubmed
    ..We further demonstrate that human and murine cells contain at least two genes encoding IFN-induced GBPs. The cloned murine cDNA codes for GBP-1, an IFN-induced protein previously shown to be absent from mice of Gbp-1b genotype. ..
  17. Costa Franco M, Marim F, Guimarães E, Assis N, Cerqueira D, Alves Silva J, et al. Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. J Immunol. 2018;200:607-622 pubmed publisher
    ..engage the type I IFN pathway, but only STING is required to induce IL-1β secretion, caspase-1 activation, and GBP2 and GBP3 expression...
  18. Haldar A, Foltz C, Finethy R, Piro A, Feeley E, Pilla Moffett D, et al. Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. Proc Natl Acad Sci U S A. 2015;112:E5628-37 pubmed publisher
    ..Our results define a ubiquitin-centered mechanism by which host cells deliver GBPs to PVs and explain how hypervirulent parasites evade GBP-mediated immunity. ..
  19. Yang W, Zhou D, Zou Y, Chen K, Liu Q, Wang J, et al. Vaccination with a DNA vaccine encoding Toxoplasma gondii ROP54 induces protective immunity against toxoplasmosis in mice. Acta Trop. 2017;176:427-432 pubmed publisher
    ..protein 54 (ROP54) has been indicated as a virulence factor that promotes Toxoplasma infection by modulating GBP2 loading onto parasite-containing vacuoles, which can modulate some aspects of the host immune response...
  20. Guimarães D, Oliveira I, de Moraes E, Paiva G, Souza D, Barnas C, et al. Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas. Int J Cancer. 2009;124:272-9 pubmed publisher
    ..TP53 mutant V272M, and (ii) investigated the expression of one of those genes, the interferon-inducible Guanylate Binding Protein 2 (GBP-2), in esophageal SCC tissues. Clontech Human Cancer 1...
  21. Lukasiewicz R, Velazquez Dones A, Huynh N, Hagopian J, Fu X, Adams J, et al. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007;282:23036-43 pubmed
    ..Thus, there are physical attributes of SR and SR-like substrates that dictate the mechanism of phosphorylation, whereas the ability to processively phosphorylate substrates is inherent to SR protein kinases. ..
  22. Abdullah N, Balakumari M, Sau A. Dimerization and its role in GMP formation by human guanylate binding proteins. Biophys J. 2010;99:2235-44 pubmed publisher
    ..Similar to hGBP-1, hGBP-2 showed dimerization-related GTPase activity for GMP formation, indicating that this family of proteins follows a broadly similar mechanism for GTP hydrolysis. ..
  23. Britzen Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S, et al. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. PLoS ONE. 2010;5:e14246 pubmed publisher
    ..Overall, these findings prove in vivo the ability of GBPs to dimerize, indicate that heterodimerization regulates sub-cellular localization of GBPs and underscore putative membrane-associated functions of this family of proteins. ..
  24. Zhang J, Zhang Y, Wu W, Wang F, Liu X, Shui G, et al. Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion. Cell Death Dis. 2017;8:e3151 pubmed publisher
    Guanylate-binding protein 2 (GBP2) is a member of the large GTPase superfamily that is strongly induced by interferon-? (IFN-?)...
  25. Nitsche E, Moquin A, Adams P, Guenette R, Lakins J, Sinnecker G, et al. Differential display RT PCR of total RNA from human foreskin fibroblasts for investigation of androgen-dependent gene expression. Am J Med Genet. 1996;63:231-8 pubmed
    ..from unknown genes; the other two show significant homology to the cDNAs of ubiquitin and human guanylate binding protein 2 (GBP-2)...
  26. Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, et al. Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature. 2017;551:378-383 pubmed publisher
    ..In the absence of IpaH9.8, or when binding of GBPs to IpaH9.8 was disrupted, GBPs such as hGBP1 and mouse GBP2 (mGBP2) translocated to intracellular S. flexneri and inhibited bacterial replication...
  27. Al Zeer M, Al Younes H, Lauster D, Abu Lubad M, Meyer T. Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins. Autophagy. 2013;9:50-62 pubmed publisher
    ..Through their capacity to remodel classically nonfusogenic chlamydial inclusions and stimulate fusion with autophagosomes, hGBP1/2 disable a major chlamydial virulence mechanism and contribute to IFNG-mediated pathogen clearance. ..
  28. Godoy P, Cadenas C, Hellwig B, Marchan R, Stewart J, Reif R, et al. Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. Breast Cancer. 2014;21:491-9 pubmed publisher
    Recently, interferon-inducible guanylate binding protein (GBP2) has been discussed as a possible control factor in tumor development, which is controlled by p53, and inhibits NF-Kappa B and Rac protein as well as expression of matrix ..
  29. Piro A, Hernandez D, Luoma S, Feeley E, Finethy R, Yirga A, et al. Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. MBio. 2017;8: pubmed publisher
    ..unique triple-arginine motif present in its C terminus, promotes the corecruitment of four additional GBP paralogs (GBP2, GBP3, GBP4, and GBP6)...
  30. Wandel M, Pathe C, Werner E, Ellison C, Boyle K, von der Malsburg A, et al. GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. Cell Host Microbe. 2017;22:507-518.e5 pubmed publisher
    ..8, a bacterial ubiquitin ligase secreted into the host cytosol. IpaH9.8 ubiquitylates GBP1, GBP2, and GBP4 to cause the proteasome-dependent destruction of existing GBP coats...
  31. Lin X, Rice K, Buzzai M, Hexner E, Costa F, Kilpivaara O, et al. miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. Leukemia. 2013;27:344-52 pubmed publisher
    ..Its novel target GBP2 is downregulated during normal erythropoiesis and regulates proliferation and erythroid differentiation in TF-1 ..
  32. Kobayashi S, Nagano H, Marubashi S, Hama N, Eguchi T, Takeda Y, et al. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes of liver transplant recipients as a marker for acute cellular rejection. Transpl Int. 2010;23:390-6 pubmed publisher
    Previously, we reported guanylate-binding protein 2 (GBP2) and interferon regulatory factor 1 (IRF1) elevated in the rat peripheral blood during acute cellular rejection (ACR), which are identified from transcriptome analysis of liver ..
  33. Neun R, Richter M, Staeheli P, Schwemmle M. GTPase properties of the interferon-induced human guanylate-binding protein 2. FEBS Lett. 1996;390:69-72 pubmed
    ..Thus, hGBP1 and hGBP2 have similar biochemical properties, but show pronounced differences in product specificity. ..