Gene Symbol: GBP1
Description: guanylate binding protein 1
Alias: guanylate-binding protein 1, GBP-1, GTP-binding protein 1, guanine nucleotide-binding protein 1, guanylate binding protein 1, interferon-inducible, 67kDa, huGBP-1, interferon-induced guanylate-binding protein 1
Species: human
Products:     GBP1

Top Publications

  1. Vöpel T, Syguda A, Britzen Laurent N, Kunzelmann S, Lüdemann M, Dovengerds C, et al. Mechanism of GTPase-activity-induced self-assembly of human guanylate binding protein 1. J Mol Biol. 2010;400:63-70 pubmed publisher
    Human guanylate binding protein 1 (hGBP1) belongs to the dynamin superfamily of large GTPases (LGs)...
  2. Guenzi E, Töpolt K, Cornali E, Lubeseder Martellato C, Jörg A, Matzen K, et al. The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. EMBO J. 2001;20:5568-77 pubmed
  3. Praefcke G, Kloep S, Benscheid U, Lilie H, Prakash B, Herrmann C. Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. J Mol Biol. 2004;344:257-69 pubmed
    ..In summary, mutants of hGBP1 were identified and biochemically characterized providing hGBP1 locked in defined states in order to investigate their functional role in future cell biology studies. ..
  4. Lubeseder Martellato C, Guenzi E, Jörg A, Töpolt K, Naschberger E, Kremmer E, et al. Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. Am J Pathol. 2002;161:1749-59 pubmed
    ..These results indicate that GBP-1 is a novel cellular activation marker that characterizes the IC-activated phenotype of endothelial cells. ..
  5. Abdullah N, Balakumari M, Sau A. Dimerization and its role in GMP formation by human guanylate binding proteins. Biophys J. 2010;99:2235-44 pubmed publisher
    ..Similar to hGBP-1, hGBP-2 showed dimerization-related GTPase activity for GMP formation, indicating that this family of proteins follows a broadly similar mechanism for GTP hydrolysis. ..
  6. Modiano N, Lu Y, Cresswell P. Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. Proc Natl Acad Sci U S A. 2005;102:8680-5 pubmed
    ..Finally, two nonhydrolyzing mutants of hGBP-1, corresponding to active mutants of Ras family proteins, failed to constitutively associate with the Golgi; we propose three possible explanations for this surprising result. ..
  7. Lipnik K, Naschberger E, Gonin Laurent N, Kodajova P, Petznek H, Rungaldier S, et al. Interferon gamma-induced human guanylate binding protein 1 inhibits mammary tumor growth in mice. Mol Med. 2010;16:177-87 pubmed publisher
    ..Consequently, owing to these activities GBPs might be considered as potent members in an innate, IFN-gamma-induced antitumoral defense system. ..
  8. Abdullah N, Srinivasan B, Modiano N, Cresswell P, Sau A. Role of individual domains and identification of internal gap in human guanylate binding protein-1. J Mol Biol. 2009;386:690-703 pubmed publisher
  9. Nantais D, Schwemmle M, Stickney J, Vestal D, Buss J. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. J Leukoc Biol. 1996;60:423-31 pubmed
    ..The human GBP1 protein, when expressed in transfected COS-1 cells, incorporates radioactivity from the isoprenoid precursor [3H]..

More Information


  1. Ghosh A, Praefcke G, Renault L, Wittinghofer A, Herrmann C. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature. 2006;440:101-4 pubmed
    ..Interferon-gamma-inducible human guanylate binding protein 1 (hGBP1) belongs to the family of dynamin-related large GTP-binding proteins, which share biochemical ..
  2. Weinländer K, Naschberger E, Lehmann M, Tripal P, Paster W, Stockinger H, et al. Guanylate binding protein-1 inhibits spreading and migration of endothelial cells through induction of integrin alpha4 expression. FASEB J. 2008;22:4168-78 pubmed publisher
    ..Endothelial cell migration is a key process during angiogenesis. Therefore, ITGA4 may be a novel molecular target to modulate angiogenesis in human disease. ..
  3. Prakash B, Praefcke G, Renault L, Wittinghofer A, Herrmann C. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature. 2000;403:567-71 pubmed
    ..Among the most abundant antiviral proteins induced by interferon-gamma are guanylate-binding proteins such as GBP1 and GBP2...
  4. Tripal P, Bauer M, Naschberger E, Mörtinger T, Hohenadl C, Cornali E, et al. Unique features of different members of the human guanylate-binding protein family. J Interferon Cytokine Res. 2007;27:44-52 pubmed
    ..These results assign a characteristic pattern of expression and subcellular localization to each of the HuGBPs, indicating for the first time that these proteins may have different cellular functions. ..
  5. Britzen Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S, et al. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. PLoS ONE. 2010;5:e14246 pubmed publisher
    ..Overall, these findings prove in vivo the ability of GBPs to dimerize, indicate that heterodimerization regulates sub-cellular localization of GBPs and underscore putative membrane-associated functions of this family of proteins. ..
  6. Naschberger E, Werner T, Vicente A, Guenzi E, Töpolt K, Leubert R, et al. Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. Biochem J. 2004;379:409-20 pubmed
    ..Our findings may open new perspectives for the use of NF-kappaB inhibitors to support angiogenesis in inflammatory diseases including ischaemia. ..
  7. Kunzelmann S, Praefcke G, Herrmann C. Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1). J Biol Chem. 2006;281:28627-35 pubmed
    Within the family of large GTP-binding proteins, human guanylate binding protein 1 (hGBP1) belongs to a subgroup of interferon-inducible proteins...
  8. Guenzi E, Töpolt K, Lubeseder Martellato C, Jörg A, Naschberger E, Benelli R, et al. The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. EMBO J. 2003;22:3772-82 pubmed
    ..These findings substantiate the role of GBP-1 as a major regulator of the anti-angiogenic response of ECs to ICs. ..
  9. Schnoor M, Betanzos A, Weber D, Parkos C. Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis. Mucosal Immunol. 2009;2:33-42 pubmed publisher
    ..These data suggest that GBP-1 is a novel marker of intestinal mucosal inflammation that may protect against epithelial apoptosis induced by inflammatory cytokines and subsequent loss of barrier function. ..
  10. Al Zeer M, Al Younes H, Lauster D, Abu Lubad M, Meyer T. Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins. Autophagy. 2013;9:50-62 pubmed publisher
    ..Through their capacity to remodel classically nonfusogenic chlamydial inclusions and stimulate fusion with autophagosomes, hGBP1/2 disable a major chlamydial virulence mechanism and contribute to IFNG-mediated pathogen clearance. ..
  11. Naschberger E, Lubeseder Martellato C, Meyer N, Gessner R, Kremmer E, Gessner A, et al. Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. Am J Pathol. 2006;169:1088-99 pubmed
    ..In this first report of a secreted GTPase, we demonstrate that secreted hGBP-1 may be a useful surrogate marker for diagnosis of bacterial meningitis. ..
  12. Niculescu A, Le Niculescu H, Levey D, ROSEBERRY K, Soe K, Rogers J, et al. Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Mol Psychiatry. 2019;24:501-522 pubmed publisher
    ..with best overall convergent functional evidence for involvement in pain were GNG7, CNTN1, LY9, CCDC144B, and GBP1. Some of the individual biomarkers identified are targets of existing drugs...
  13. Quintero M, Adamoski D, Reis L, Ascenção C, Oliveira K, Gonçalves K, et al. Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer. BMC Cancer. 2017;17:727 pubmed publisher
    ..We finally demonstrated that knock-down of Guanylate-Binding Protein 1 (GBP1 ), one of the candidate genes, selectively affected the growth of TNBC cell lines...
  14. Gao F, Zhao Z, Zhao W, Fan Q, Wang S, Li J, et al. miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells. Biochem Biophys Res Commun. 2013;431:610-6 pubmed publisher
    ..g., IFI44L, PSMB8, IRF5, PSMB10, IFI27, PSB9_HUMAN, IFIT2, TRAIL, IFIT1, PSB8_HUMAN, IRF1, B2M and GBP1), major histocompatibility complex (MHC) class I molecules (e.g...
  15. Mufarrege E, Haile L, Etcheverrigaray M, Verthelyi D. Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs). AAPS J. 2019;21:26 pubmed publisher
    ..there were differences in the expression of a subset of interferon-inducible genes including CXCL-10, CXCL-11, and GBP1 induced by the biosimilar candidate for Betaseron...
  16. Zhao Y, Xu G, Yang P. GBP1 exerts inhibitory effects on acute viral myocarditis through the inhibition of inflammatory response of macrophage in mice. Biochem Cell Biol. 2018;: pubmed publisher
    ..Interferon-induced GBP1 encodes much GTPase induced by interferon gamma in many eukaryotic cells...
  17. Elias D, Vever H, Lænkholm A, Gjerstorff M, Yde C, Lykkesfeldt A, et al. Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy. Oncogene. 2015;34:1919-27 pubmed publisher cell proliferation, death and control of gene expression, and include FYN, PRKCA, ITPR1, DPYD, DACH1, LYN, GBP1 and PRLR...
  18. Feeley E, Pilla Moffett D, Zwack E, Piro A, Finethy R, Kolb J, et al. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017;114:E1698-E1706 pubmed publisher
    ..secretion systems directs cytosolic carbohydrate-binding protein Galectin-3 to PVs and that the delivery of GBP1 and GBP2 to Legionella-containing vacuoles or YCVs is substantially diminished in Galectin-3-deficient cells...
  19. Koyama T, Mirth C. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. PLoS Biol. 2016;14:e1002392 pubmed publisher
    ..Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling...
  20. Hastie E, Cataldi M, Moerdyk Schauwecker M, Felt S, Steuerwald N, Grdzelishvili V. Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Oncotarget. 2016;7:61601-61618 pubmed publisher
    ..Further RNA and protein analyses demonstrated that 4 of these genes (MX1, EPSTI1, XAF1, and GBP1) are constitutively co-expressed in VSV-resistant, but not in VSV-permissive PDACs, thus serving as potential ..
  21. Liu M, Liu J, Hao S, Wu P, Zhang X, Xiao Y, et al. Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity. Clin Rheumatol. 2018;37:2675-2684 pubmed publisher
    ..Quantitative real-time PCR was used to assess the mRNA expression of IFNG, type II IFN-inducible genes (IRF1, GBP1, CXCL9, CXCL10, and SERPING1, which are used for the type II IFN score), type I IFN-inducible genes (IRF7, MX1, ..
  22. Wang L, Yao Z, Moorman J, Xu Y, Ning S. Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies. PLoS ONE. 2014;9:e106788 pubmed publisher
    ..the IRF4 transcriptome in the context of EBV latent infection, and confirmed several genes including IFI27, IFI44, GBP1, and ARHGAP18, as well as CFLAR as novel targets for IRF4...
  23. Petzke M, Iyer R, Love A, Spieler Z, Brooks A, Schwartz I. Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice. BMC Microbiol. 2016;16:29 pubmed publisher
    ..burgdorferi. The mean values for transcripts of Ifnb, Cxcl10, Gbp1, Ifit1, Ifit3, Irf7, Mx1, and Stat2 were found to be significantly increased in B...
  24. Harvey R, McCaughan C, Wise L, Mercer A, Fleming S. Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway. Virus Res. 2015;208:180-8 pubmed publisher
    ..We investigated whether or not ORFV could block the expression of ISGs. The human gene GBP1 is stimulated exclusively by type II IFN while MxA is stimulated exclusively in response to type I IFNs...
  25. Li L, Lingaraju M, Basquin C, Basquin J, Conti E. Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins. RNA. 2017;23:1028-1034 pubmed publisher
    ..a G-domain heterodimer with architectural similarities to the dynamin-like family of GTPases such as Atlastin and GBP1. The SMG8-SMG9 heterodimer forms in the absence of nucleotides, with interactions conserved from worms to humans...
  26. Jiang L, Saetre P, Radomska K, Jazin E, Lindholm Carlström E. QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells. PLoS ONE. 2010;5: pubmed publisher
    ..3E-10), including IFIT1, IFIT2, MX1, MX2, G1P2, G1P3, GBP1 and IFIH1...
  27. Bai S, Mu Z, Huang Y, Ji P. Guanylate Binding Protein 1 Inhibits Osteogenic Differentiation of Human Mesenchymal Stromal Cells Derived from Bone Marrow. Sci Rep. 2018;8:1048 pubmed publisher
    ..Previous studies have shown high expression of GBP1 in circulating monocytes of premenopausal subjects was correlated to extremely low peak bone mass, which is ..
  28. Foltz C, Napolitano A, Khan R, Clough B, Hirst E, Frickel E. TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles. Sci Rep. 2017;7:5209 pubmed publisher
    ..We demonstrate that IFNγ drives recruitment of TRIM21 to GBP1-positive Toxoplasma vacuoles, leading to Lys63-linked ubiquitination of the vacuole and restriction of parasite ..
  29. do Nascimento N, Guimaraes A, Dos Santos A, Chu Y, Marques L, Messick J. RNA-Seq based transcriptome of whole blood from immunocompetent pigs (Sus scrofa) experimentally infected with Mycoplasma suis strain Illinois. Vet Res. 2018;49:49 pubmed publisher innate immunity (tlr8, chemokines, chemokines receptors) and genes containing IFN gamma-activated sequence (gbp1, gbp2, il15, cxcl10, casp1, cd274) suggests a general suppression of the immune response in the infected animals...
  30. Wang X, Peng Y, Song X, Lan J. Identification potential biomarkers and therapeutic agents in multiple myeloma based on bioinformatics analysis. Eur Rev Med Pharmacol Sci. 2016;20:810-7 pubmed
    ..Up-regulated gene of guanylate binding protein 1, interferon-inducible (GBP1) was a hub node in immune response-related co-expression network...
  31. Niu P, Shabir N, Khatun A, Seo B, Gu S, Lee S, et al. Effect of polymorphisms in the GBP1, Mx1 and CD163 genes on host responses to PRRSV infection in pigs. Vet Microbiol. 2016;182:187-95 pubmed publisher
    ..Guanylate-binding protein 1 (GBP1) and myxovirus resistance protein 1 (Mx1) are two important proteins belonging to the GTPase superfamily that have ..
  32. Lebosse F, Testoni B, Fresquet J, Facchetti F, Galmozzi E, Fournier M, et al. Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B. J Hepatol. 2017;66:897-909 pubmed publisher
    ..A subset of genes [CXCL10, GBP1, IFITM1, IFNB1, IL10, IL6, ISG15, TLR3, SOCS1, SOCS3] was more repressed in HBeAg(-) respect to HBeAg(+) patients (..
  33. Abella G, Pena R, Nogareda C, Armengol R, Vidal A, Moradell L, et al. A WUR SNP is associated with European Porcine Reproductive and Respiratory Virus Syndrome resistance and growth performance in pigs. Res Vet Sci. 2016;104:117-22 pubmed publisher
    ..nucleotide polymorphism (SNP) WUR10000125 (WUR) at the interferon-inducible guanylate-binding protein 1 gene (GBP1) with average daily gain (ADG) in PRRSV infected and uninfected pigs...
  34. McDonald J, Kaforou M, Clare S, Hale C, Ivanova M, Huntley D, et al. A Simple Screening Approach To Prioritize Genes for Functional Analysis Identifies a Role for Interferon Regulatory Factor 7 in the Control of Respiratory Syncytial Virus Disease. mSystems. 2016;1: pubmed
    ..RSV infection with no assigned function in RSV control, including IFI27, IFIT3, IFI44L, GBP1, OAS3, IFI44, and IRF7...
  35. Shields G, Bates A, Chapman A. Implementing Guidelines: The Cost and Clinical Impact of Anticoagulants in the UK Atrial Fibrillation Population. Appl Health Econ Health Policy. 2015;13:543-51 pubmed publisher
    ..This would rise to GBP1,004,900 in Year 5 to treat an additional 2242 patients, with all eligible patients treated by this year...
  36. Mustafa D, Pedrosa R, Smid M, van der Weiden M, de Weerd V, Nigg A, et al. T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression. Acta Neuropathol. 2018;135:581-599 pubmed publisher
    ..Proteomics analysis of the tumor cells revealed Guanylate-Binding Protein 1 (GBP1) as a key T lymphocyte-induced protein that enables breast cancer cells to cross the BBB...
  37. Gol S, Estany J, Fraile L, Pena R. Expression profiling of the GBP1 gene as a candidate gene for porcine reproductive and respiratory syndrome resistance. Anim Genet. 2015;46:599-606 pubmed publisher
    ..polyadenylation site in the 3'-untranslated region (3'-UTR) of the guanylate-binding protein 1, interferon-induced (GBP1) gene. The protein encoded by GBP1 is a negative regulator of T-cell responses...
  38. Li L, Yu J, Li Y, Wang J, Li S, Zhang L, et al. Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity. J Virol. 2016;90:4412-4426 pubmed publisher
    ..against CSFV in lentivirus-delivered cell lines, resulting in the identification of guanylate-binding protein 1 (GBP1) as a potent anti-CSFV ISG...
  39. Li H, Zhao X, Wang J, Zong M, Yang H. Bioinformatics analysis of gene expression profile data to screen key genes involved in pulmonary sarcoidosis. Gene. 2017;596:98-104 pubmed publisher
    ..In the PPI network constructed by STRING database, CXCL9, STAT1, CCL5, CXCL11 and GBP1 had higher degrees and betweenness values, and could interact with each other...
  40. Qiu X, Guo H, Yang J, Ji Y, Wu C, Chen X. Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages. Sci Rep. 2018;8:1679 pubmed publisher
    ..Herein, we explored the role of guanylate binding protein 1 (Gbp1), an intracellular anti-microbial protein, in regulating polarization, metabolic reprogramming, ..
  41. Wang X, Wang S, Zhou L, Yu L, Zhang L. A network-pathway based module identification for predicting the prognosis of ovarian cancer patients. J Ovarian Res. 2016;9:73 pubmed
    ..functional interaction modules (31: DCLRE1A, EXO1, KIAA0101, KIN, PCNA, POLD3, POLD2; 35: DKK3, FABP3, IRF1, AIM2, GBP1, GBP2, IRF2) that are associated with prognosis of ovarian cancer patients...
  42. Encheva V, Foltz C, Snijders A, Frickel E. Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection. BMC Res Notes. 2018;11:166 pubmed publisher
    ..In addition, we compared peptide levels between WT and TRIM21-/- cells. In line with earlier reports, Gbp1 was expressed to higher levels in the C57BL/6×129 WT MEFs compared to the C57BL/6-only background TRIM21-/-
  43. Friedman K, Brodsky A, Lu S, Wood S, Gill A, Lombardo K, et al. Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment. Mod Pathol. 2016;29:528-41 pubmed publisher
    ..significant upregulation of several immunoregulatory genes induced by IFNγ including IDO-1, WARS (tRNA(trp)), GBP1, GBP4, GBP5, PDCD1 (PD-1), and CD274 (PD-L1) in medullary carcinoma compared with other microsatellite unstable and ..
  44. Zou Z, Meng Z, Ma C, Liang D, Sun R, Lan K. Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament. J Virol. 2017;91: pubmed publisher
    ..The guanylate-binding protein 1 (GBP1) gene is an interferon-stimulated gene and exerts antiviral functions on several RNA viruses; however, its function ..
  45. Pammer J, Reinisch C, Birner P, Pogoda K, Sturzl M, Tschachler E. Interferon-alpha prevents apoptosis of endothelial cells after short-term exposure but induces replicative senescence after continuous stimulation. Lab Invest. 2006;86:997-1007 pubmed
    ..Furthermore IFN-alpha released in chronic inflammatory conditions might contribute via its prosenescent activity to the pathogenesis of atherosclerosis. ..
  46. Saunders N, Smith R, Jetten A. Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells. J Invest Dermatol. 1999;112:977-83 pubmed
  47. Johnston A, PIRO A, Clough B, Siew M, Virreira Winter S, Coers J, et al. Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Cell Microbiol. 2016;18:1056-64 pubmed publisher
    ..This study highlights fundamental differences between human and murine GBPs and underlines the need to study the functions of GBPs at cellular locations away from PVs. ..
  48. Ince S, Kutsch M, Shydlovskyi S, Herrmann C. The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only. FEBS J. 2017;284:2284-2301 pubmed publisher
    ..Thus, previously reported tetrameric and dimeric species of hGBP-1 and hGBP-5 were unmasked as dimers and monomers, respectively, with their shapes depending on both the bound nucleotide and the ionic strength of the solution. ..
  49. Hammon M, Herrmann M, Bleiziffer O, Pryymachuk G, Andreoli L, Munoz L, et al. Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases. J Cell Mol Med. 2011;15:1582-92 pubmed publisher
    ..Overall, our findings indicate that GBP-1 contributes to vascular dysfunction in chronic inflammatory diseases by inhibiting EPC angiogenic activity via the induction of premature EPC differentiation. ..
  50. Lei S, Wu S, Li L, Deng F, Xiao S, Jiang C, et al. An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone. 2009;44:1010-4 pubmed publisher
    ..rate adjustment, three genes [STAT1, signal transducer and activator of transcription 1; GBP1, guanylate binding protein 1; CXCL10, Chemokine (C-X-C motif) ligand 10] expressed significantly differentially (p<0.05)...
  51. Yu C, Chang K, Chang Y, Hsu C, Liang Y, Yu J, et al. Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J Proteome Res. 2011;10:3778-88 pubmed publisher
    ..Among the 19 candidates isolated, guanylate-binding protein 1 (GBP1) was selected for further validation using serum samples from OSCC patients and healthy controls...
  52. Ostler N, Britzen Laurent N, Liebl A, Naschberger E, Lochnit G, Ostler M, et al. Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor. Mol Cell Biol. 2014;34:196-209 pubmed publisher
    ..The large GTPase guanylate binding protein 1 (GBP-1) is among the cellular proteins that is the most abundantly induced by IFN-? and mediates its ..
  53. Naschberger E, Bauer M, Sturzl M. Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. Adv Enzyme Regul. 2005;45:215-27 pubmed
    ..In future, hGBP-1 may be used as a marker to monitor the IC-induced phenotype of EC in inflammation and may also be exploited as a target to modulate EC activity in inflammatory diseases and tumor angiogenesis. ..
  54. Anderson N, Anderson N. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1:845-67 pubmed
  55. Li L, Ma G, Jing C, Liu Z. Guanylate-binding protein 1 (GBP1) promotes lymph node metastasis in human esophageal squamous cell carcinoma. Discov Med. 2015;20:369-78 pubmed
    ..Guanylate-binding protein 1 (GBP1) is a GTP-binding protein family member with high GTPase activity...
  56. Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, et al. Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance. Cancer Sci. 2014;105:1351-9 pubmed publisher
    ..We studied three human and one murine cell line, and their CRR derivatives. Guanine nucleotide-binding protein 1 (GBP1) gene expression was higher in all CRR cells than their corresponding parental cells...
  57. Cheng Y, Patterson C, Staeheli P. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol. 1991;11:4717-25 pubmed
    ..We further demonstrate that human and murine cells contain at least two genes encoding IFN-induced GBPs. The cloned murine cDNA codes for GBP-1, an IFN-induced protein previously shown to be absent from mice of Gbp-1b genotype. ..
  58. Qin A, Lai D, Liu Q, Huang W, Wu Y, Chen X, et al. Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2017;114:1365-1370 pubmed publisher
    ..gondii infection. Taken together, our results suggest that hGBP1 plays a pivotal role in anti-T. gondii protection of hMSCs and may shed new light on clarifying the mechanism of host defense properties of hMSCs. ..
  59. Piro A, Hernandez D, Luoma S, Feeley E, Finethy R, Yirga A, et al. Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. MBio. 2017;8: pubmed publisher
    ..Here, we demonstrate that human GBP1 is unique among the seven human GBP paralogs in its ability to associate with at least two cytosolic Gram-negative ..
  60. Strehlow I, Lohmann Matthes M, Decker T. The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. Gene. 1994;144:295-9 pubmed
    We have isolated DNA clones containing the interferon (IFN)-inducible guanylate-binding protein-1-encoding gene (GBP1) from a human genomic library. Two overlapping phage clones contained the entire GBP1 gene...
  61. Pandita E, Rajan S, Rahman S, Mullick R, Das S, Sau A. Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity. Biochem J. 2016;473:1745-57 pubmed publisher
    ..Thus, the present study not only highlights the importance of hGBP1 tetramer in stimulated GMP formation, but also demonstrates its role in the antiviral activity against hepatitis C virus. ..
  62. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..In this article, we show that the IFN-?-inducible guanylate binding protein 1 (GBP-1) is a regulator of T cell activation...
  63. Fatemi F, Amini S, Kharrazi S, Rasaee M, Mazlomi M, Asadi Ghalehni M, et al. Construction of genetically engineered M13K07 helper phage for simultaneous phage display of gold binding peptide 1 and nuclear matrix protein 22 ScFv antibody. Colloids Surf B Biointerfaces. 2017;159:770-780 pubmed publisher
    ..with energy dispersive X-ray spectroscopy (EDX) analysis revealed that the expression of gold binding peptide 1 (GBP1) on major coat protein p8 significantly enhances the gold-binding affinity of M13 phages...
  64. Lundberg M, Krogvold L, Kuric E, Dahl Jørgensen K, Skog O. Expression of Interferon-Stimulated Genes in Insulitic Pancreatic Islets of Patients Recently Diagnosed With Type 1 Diabetes. Diabetes. 2016;65:3104-10 pubmed publisher
    ..Most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-..
  65. Naschberger E, Croner R, Merkel S, Dimmler A, Tripal P, Amann K, et al. Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy. Int J Cancer. 2008;123:2120-9 pubmed publisher
    ..Moreover, the induction of a Th-1-like angiostatic immune reaction may be a promising approach for the clinical treatment of CRC. ..
  66. Li M, Mukasa A, Inda M, Zhang J, Chin L, Cavenee W, et al. Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. J Exp Med. 2011;208:2657-73 pubmed publisher
    Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown...
  67. Lan Q, Wang A, Cheng Y, Mukasa A, Ma J, Hong L, et al. Guanylate binding protein-1 mediates EGFRvIII and promotes glioblastoma growth in vivo but not in vitro. Oncotarget. 2016;7:9680-91 pubmed publisher
    ..We previously reported that Guanylate binding protein-1 (GBP1) is a novel transcriptional target gene of EGFR and plays a role in GBM invasion...
  68. Syguda A, Bauer M, Benscheid U, Ostler N, Naschberger E, Ince S, et al. Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal ?-helices. FEBS J. 2012;279:2544-54 pubmed publisher
    ..Furthermore, we can demonstrate the biological relevance of hGBP1 tetramer formation in living cells by chemical cross-link experiments. ..
  69. Tipton A, Nyabuto G, Trendel J, Mazur T, Wilson J, Wadi S, et al. Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. Biochem Biophys Res Commun. 2016;478:1617-23 pubmed publisher
    ..Breast cancer cell lines express the 44 kDa isoform of PIM-1, and ovarian cancer cell lines express the 33 kDa isoform. ..
  70. Ito Y, Shibata Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, et al. Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. J Infect Dis. 2008;197:663-6 pubmed publisher
    ..Eventually, 3 genes were found to be significantly upregulated: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5...
  71. Adkins J, Varnum S, Auberry K, Moore R, Angell N, Smith R, et al. Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol Cell Proteomics. 2002;1:947-55 pubmed
    ..With this study, we have performed the most extensive analysis of serum proteins to date and laid the foundation for future refinements in the identification of novel protein biomarkers of disease. ..
  72. Mirpuri J, Brazil J, Berardinelli A, Nasr T, Cooper K, Schnoor M, et al. Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine. J Immunol. 2010;184:7186-95 pubmed publisher
  73. Vöpel T, Hengstenberg C, Peulen T, Ajaj Y, Seidel C, Herrmann C, et al. Triphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-terminal helices: a joint double electron-electron resonance and FRET study. Biochemistry. 2014;53:4590-600 pubmed publisher
    Human guanylate binding protein 1 (hGBP1) is a member of the dynamin superfamily of large GTPases. During GTP hydrolysis, the protein undergoes structural changes leading to self-assembly...
  74. Sahu M, Mallick B. An integrative approach predicted co-expression sub-networks regulating properties of stem cells and differentiation. Comput Biol Chem. 2016;64:250-262 pubmed publisher
    ..thereby promoting EBs to Fibs differentiation by: (i) modulating extracellular matrix involving ITGB1, TGFB1I1 and GBP1, (ii) regulating cell cycle remodeling involving CDKN1A, JUNB and DUSP1 and (iii) helping in epithelial to ..
  75. Wehner M, Kunzelmann S, Herrmann C. The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis. FEBS J. 2012;279:203-10 pubmed publisher
    ..We suggest that this contact structurally couples the guanine cap to the switch regions of the GTPase, translating the structural changes that occur upon nucleotide binding to a change in oligomerization and self-activation. ..
  76. Capaldo C, Beeman N, Hilgarth R, Nava P, Louis N, Naschberger E, et al. IFN-? and TNF-?-induced GBP-1 inhibits epithelial cell proliferation through suppression of ?-catenin/TCF signaling. Mucosal Immunol. 2012;5:681-90 pubmed publisher
    ..Together, these data show that cytokine-induced GBP-1 retards cell proliferation by forming a negative feedback loop that suppresses ?-catenin/TCF signaling. ..
  77. Persico M, Petrella L, Orteca N, Di Dato A, Mariani M, Andreoli M, et al. GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1. Eur J Med Chem. 2015;91:132-44 pubmed publisher
    b>GBP1 and PIM1 are known to interact with a molar ratio 1:1. GBP1:PIM1 binding initiates a signaling pathway that induces resistance to common chemotherapeutics such as paclitaxel...
  78. Kumar S, Li Q, Dua A, Ying Y, Bagchi M, Bagchi I. Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation. J Clin Endocrinol Metab. 2001;86:2420-7 pubmed
    ..We identified one of these genes as that encoding interferon (IFN)-inducible guanylate-binding protein 1 (or GBP1), which possesses GTPase activity...
  79. Rani A, Pandita E, Rahman S, Deep S, Sau A. Insight into temperature dependence of GTPase activity in human guanylate binding protein-1. PLoS ONE. 2012;7:e40487 pubmed publisher
    ..Thus, this study provides the first thermodynamic insight into the effect of temperature in the product formation of hGBP1. ..
  80. Britzen Laurent N, Lipnik K, Ocker M, Naschberger E, Schellerer V, Croner R, et al. GBP-1 acts as a tumor suppressor in colorectal cancer cells. Carcinogenesis. 2013;34:153-62 pubmed publisher
    ..Altogether, these results suggested that GBP-1 acts directly as a tumor suppressor in CRC and the loss of GBP-1 expression might indicate tumor evasion from the IFN-?-dominated Th1 immune response. ..
  81. Li P, Jiang W, Yu Q, Liu W, Zhou P, Li J, et al. Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence. Nature. 2017;551:378-383 pubmed publisher
    ..flexneri and inhibited bacterial replication. Like wild-type mice, mutant mice deficient in GBP1-3, 5 and 7 succumbed to S...
  82. Vöpel T, Kunzelmann S, Herrmann C. Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis. FEBS Lett. 2009;583:1923-7 pubmed publisher
    ..Our results indicate that nucleotide hydrolysis induces a domain movement in hGBP1, which we suggest enables further assembly of the protein. ..
  83. Wandel M, Pathe C, Werner E, Ellison C, Boyle K, von der Malsburg A, et al. GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. Cell Host Microbe. 2017;22:507-518.e5 pubmed publisher
    ..GTPase family of guanylate-binding proteins (GBPs) coats Shigella flexneri in a hierarchical manner reliant on GBP1. GBPs inhibit actin-dependent motility and cell-to-cell spread of bacteria but are antagonized by IpaH9...
  84. Zhu Z, Wei J, Shi Z, Yang Y, Shao D, Li B, et al. Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53. Biochem Biophys Res Commun. 2013;436:204-11 pubmed publisher
    ..Among three deductive p53REs present in the hGBP1 promoter region, two p53REs were found to be transactivated by p53. ..
  85. Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Sturzl M, et al. Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity. J Cell Mol Med. 2017;21:1954-1966 pubmed publisher
    ..These findings confirm the involvement of caspase-1 in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1. ..