Genomes and Genes
Gene Symbol: Gbeta
Description: G protein subunit beta 1
Alias: MRD42, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, beta subunit, signal-transducing proteins GS/GI, guanine nucleotide binding protein (G protein), beta polypeptide 1, testicular tissue protein Li 72, transducin beta chain 1
Publications111 found, 100 shown here
- Agler H, Evans J, Tay L, Anderson M, Colecraft H, Yue D. G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels. Neuron. 2005;46:891-904 pubmed..Thus, an NT module, acting via interactions with the I-II loop, appears fundamental to such modulation. ..
- Coughlin S. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005;3:1800-14 pubmed
- Iacovelli L, Capobianco L, Iula M, Di Giorgi Gerevini V, Picascia A, Blahos J, et al. Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). Mol Pharmacol. 2004;65:1103-10 pubmed..We speculate that GRK2 acts as a "switch molecule" by inhibiting the mGlu4 receptor-mediated stimulation of MAPK and therefore directing the signal propagation toward the inhibition of adenylyl cyclase. ..
- Tsukada S, Simon M, Witte O, Katz A. Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci U S A. 1994;91:11256-60 pubmed..The interaction of Btk with beta gamma suggests the existence of a unique connection between cytoplasmic tyrosine kinases and G proteins in cellular signal transduction. ..
- Orchel J, Witek L, Kimsa M, Strzalka Mrozik B, Kimsa M, Olejek A, et al. Expression patterns of kinin-dependent genes in endometrial cancer. Int J Gynecol Cancer. 2012;22:937-44 pubmed publisher..This will eventually help to improve treatment strategies for patients with endometrial cancer in the future. ..
- Ye Y, Tang X, Sun Z, Chen S. Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion. Oncotarget. 2016;7:17854-69 pubmed publisher..Together, our results identify a novel mechanism regulating GPCR-dependent activation of the PI3K/AKT signaling axis in breast tumor cells, and pinpoint WDR26 as a potential therapeutic target for breast cancer. ..
- Offermanns S, Laugwitz K, Spicher K, Schultz G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci U S A. 1994;91:504-8 pubmed..Our results provide evidence that G12 and G13 play a functional role in transmembrane signal transduction and suggest that both proteins are involved in pathways leading to platelet activation. ..
- Mahon M, Bonacci T, Divieti P, Smrcka A. A docking site for G protein ?? subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Mol Endocrinol. 2006;20:136-46 pubmed..Herein, we define a domain on the PTH1R that is capable of binding G protein heterotrimeric complexes via direct Gbetagamma interactions. ..
- Gimenez N, Martínez Trillos A, Montraveta A, Lopez Guerra M, Rosich L, Nadeu F, et al. Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia. Haematologica. 2019;104:576-586 pubmed publisher
- Hill C, Goddard A, Ladds G, Davey J. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. Cell Physiol Biochem. 2009;23:1-8 pubmed publisher..Binding to the Gbeta subunits involves the cationic regions of AGS1 and Rhes, and we used Rhes-AGS1 chimeras to show that their ..
- Lagman D, Callado PÃ©rez A, FranzÃ©n I, Larhammar D, Abalo X. Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation. PLoS ONE. 2015;10:e0121330 pubmed publisher..In summary, this study describes several functional differences between transducin gene duplicates resulting from the teleost-specific tetraploidisation. ..
- Evanko D, Thiyagarajan M, Siderovski D, Wedegaertner P. Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. J Biol Chem. 2001;276:23945-53 pubmed
- Ahmed S, Daulat A, Meunier A, Angers S. G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil. J Biol Chem. 2010;285:6538-51 pubmed publisher..These results add to the molecular understanding of how G protein-coupled receptors impinge on cell adhesion and suggest that the Gbetagamma x Rap1 x Radil complex plays important roles in this process. ..
- Xiong Y, Zhou Y, Jarrett H. Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner. J Cell Physiol. 2009;219:402-14 pubmed publisher..Upregulating integrin beta1 expression and activating the PI3K/Akt pathway in muscular dystrophy may partially compensate for the loss of the DGC. The results suggest new therapeutic approaches to muscle disease. ..
- Knezevic N, Tauseef M, Thennes T, Mehta D. The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med. 2009;206:2761-77 pubmed publisher..We observed that in the naive endothelium Gbeta1, the predominant Gbeta isoform is sequestered by receptor for activated C kinase 1 (RACK1)...
- Manganello J, Huang J, Kozasa T, Voyno Yasenetskaya T, Le Breton G. Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem. 2003;278:124-30 pubmed..4). These results therefore suggest that PKA blocks Rho activation by phosphorylation of Galpha(13) Thr(203). ..
- Chen S, Lin F, Shin M, Wang F, Shen L, Hamm H. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell. 2008;19:3909-22 pubmed publisher..Taken together, these findings provide a novel mechanism of regulating cell migration, i.e., RACK1-mediated interference with G betagamma-dependent activation of key effectors critical for chemotaxis. ..
- Whorton M, MacKinnon R. X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature. 2013;498:190-7 pubmed publisher..The structures also permit a conceptual understanding of how the signalling lipid phosphatidylinositol-4,5-bisphosphate (PIP2) and intracellular Na(+) ions participate in multi-ligand regulation of GIRK channels. ..
- Rosskopf D, Nikula C, Manthey I, Joisten M, Frey U, Kohnen S, et al. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. FEBS Lett. 2003;544:27-32 pubmed
- Howlett A, Gray A, Hunter J, Willardson B. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. J Biol Chem. 2009;284:16386-99 pubmed publisher..that phosducin-like protein 1 (PhLP1) works as a co-chaperone with the cytosolic chaperonin complex (CCT) to fold Gbeta and mediate its interaction with Ggamma...
- Supper V, Hartl I, Boulegue C, Ohradanova Repic A, Stockinger H. Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells. J Immunol. 2017;198:2468-2478 pubmed publisher..With the generated signaling network and gene ontology biological process term grouping, we identify potential signaling routes of CD147 affecting T cell growth and function. ..
- Lukov G, Hu T, McLaughlin J, Hamm H, Willardson B. Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. EMBO J. 2005;24:1965-75 pubmed..PhLP bound nascent Gbeta in the absence of Ggamma, and S18-20 phosphorylation was required for Ggamma to associate with the PhLP-Gbeta ..
- Yang M, He R, Benovic J, Ye R. beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Biochem J. 2009;417:287-96 pubmed publisher..These results identify novel functions of beta-arrestin1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signalling for NF-kappaB activation. ..
- Pradhan S, Khatlani T, Nairn A, Vijayan K. The heterotrimeric G protein G?1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets. J Biol Chem. 2017;292:13133-13142 pubmed publisher..These findings suggest that G?1 protein enlists PP1c to modulate GPCR signaling in platelets. ..
- Ayodele B, Mirams M, Pagel C, Mackie E. The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation. Bone Rep. 2017;7:98-107 pubmed publisher..The results are consistent with roles for V-ATPase, both ATP6V0D2-dependent and -independent, in supporting chondrocyte differentiation and hypertrophy...
- Szczałuba K, Biernacka A, Szymanska K, Gasperowicz P, Kosińska J, Rydzanicz M, et al. Novel GNB1 de novo mutation in a patient with neurodevelopmental disorder and cutaneous mastocytosis: Clinical report and literature review. Eur J Med Genet. 2018;61:157-160 pubmed publisher..1: c.230G > T; p.(Gly77Val). We also present the detailed clinical and etiopathogenetic discussion on previously diagnosed patients as well as suggestions for the link of the mutation with skin disease. ..
- Mattingly R, Macara I. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature. 1996;382:268-72 pubmed..These results demonstrate a G-protein-coupled mechanism for Ras activation, mediated by p140 Ras-GRF. ..
- Wazir U, Jiang W, Sharma A, Mokbel K. Guanine nucleotide binding protein ? 1: a novel transduction protein with a possible role in human breast cancer. Cancer Genomics Proteomics. 2013;10:69-73 pubmed..525, p<0.000001) and Rictor (r=0.388, p=0.0000606). These observations may suggest that GNB1 plays an important role in the mTOR-related anti-apoptosis pathway and can potentially be targeted in the treatment of human breast cancer. ..
- N Diaye E, Brown E. The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gbetagamma. J Cell Biol. 2003;163:1157-65 pubmed..Thus, PLIC-1 inhibits Gi signaling by direct association with Gbetagamma; because it also interacts with CD47, a modulator of integrin function, it likely has a role integrating adhesion and signaling components of cell migration. ..
- Buhl A, Osawa S, Johnson G. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor. J Biol Chem. 1995;270:19828-32 pubmed..These results demonstrate that two independent signals are required for the maximal activation of MAP kinase by G protein-coupled receptors. ..
- Zhang B, Tran U, Wessely O. Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney. Development. 2018;145: pubmed publisher..Together, our data support the hypothesis that G proteins are recruited to the intracellular domain of PKD1 and that this interaction is crucial for its function in the kidney. ..
- Stefan E, Malleshaiah M, Breton B, Ear P, Bachmann V, Beyermann M, et al. PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades. Nat Commun. 2011;2:598 pubmed publisher..These findings suggest a direct mechanism by which coincident activation of G?s-coupled receptors controls the precision of adaptive responses of activated G?i-coupled receptor cascades. ..
- Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan Z, Yong S, et al. Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation. PLoS ONE. 2013;8:e52689 pubmed publisher..These findings suggest a wide-ranging mechanism by which direct interaction of G?? with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells. ..
- Agarwal N, Kim C, Kunkalla K, Konno H, Tjendra Y, Kwon D, et al. Active IKKÎ² promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood. 2016;127:605-15 pubmed publisher..By linking IKKÎ²-mediated nuclear factor-ÎºB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
- Lee C, Ahn H, Lee S, Shin J, Park W, Kim J, et al. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016;9 Suppl 1:33 pubmed publisher..Our integrated analysis of miRNA-transcriptome network and PPI network combined with qRT-PCR verifies that Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice. ..
- Ivanina T, Rishal I, Varon D, Mullner C, Frohnwieser Steinecke B, Schreibmayer W, et al. Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. J Biol Chem. 2003;278:29174-83 pubmed
- Gales C, Rebois R, Hogue M, Trieu P, Breit A, Hebert T, et al. Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods. 2005;2:177-84 pubmed..In addition to detecting basal precoupling of the receptors to Galpha-, Gbeta- and Ggamma-subunits, BRET measured very rapid ligand-induced increases in the interaction between receptor and ..
- Hiskens R, Vatish M, Hill C, Davey J, Ladds G. Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit. Biochem Biophys Res Commun. 2005;337:1038-46 pubmed..The interaction is specific for G(beta1) and involves the cationic region of AGS1 and the C-terminal region of G(beta1). Possible implications of this novel interaction for the activity of AGS1 are discussed. ..
- Baljinnyam E, Umemura M, De Lorenzo M, Xie L, NOWYCKY M, Iwatsubo M, et al. G?? subunits inhibit Epac-induced melanoma cell migration. BMC Cancer. 2011;11:256 pubmed publisher..We found the cross talk of Ca 2+ signaling between G?? and Epac, which plays a major role in melanoma cell migration. ..
- Krishnan A, Mustafa A, AlmÃ©n M, Fredriksson R, Williams M, SchiÃ¶th H. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol Phylogenet Evol. 2015;91:27-40 pubmed publisher..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
- Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, et al. Gnb isoforms control a signaling pathway comprising Rac1, PlcÎ²2, and PlcÎ²3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood. 2016;127:314-24 pubmed publisher..Taken together, we demonstrated that all Gnb isoforms are required for chemokine-induced downstream signaling, and Rac1, PlcÎ²2, and PlcÎ²3 are critically involved in integrin activation and leukocyte arrest. ..
- Huang R, He Y, Sun B, Liu B. Bioinformatic Analysis Identifies Three Potentially Key Differentially Expressed Genes in Peripheral Blood Mononuclear Cells of Patients with Takayasu's Arteritis. Cell J. 2018;19:647-653 pubmed publisher..Nevertheless, NOS3 was a significantly down-regulated gene and was involved in the platelet activation pathway. RHOA, FOS, and EGR1 are potential candidate genes for the diagnosis and therapy of TA. ..
- Waragai M, Nagamitsu S, Xu W, Li Y, Lin X, Ashizawa T. Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit. J Neurosci Res. 2006;83:1170-8 pubmed..Our data suggest that the ataxin 10-Gbeta2 interaction represents a novel mechanism for inducing neuritogenesis in PC12 cells by activating the Ras-MAP kinase-Elk-1 cascade. ..
- Seo M, Lee M, Heo J, Lee Y, Kim Y, Kim S, et al. G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. J Biol Chem. 2007;282:24720-30 pubmed..Moreover, UVB-induced apoptosis was reduced by inhibiting EGFR or p38. The overexpression of Gbeta(1)gamma(2) increased EGFR-activating activity and soluble HB-EGF content in conditioned medium, but the ..
- Martins de Souza D, Gattaz W, Schmitt A, Maccarrone G, Hunyadi Gulyas E, Eberlin M, et al. Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. J Psychiatr Res. 2009;43:978-86 pubmed publisher..Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease. ..
- Yeh C, Li A, Chuang J, Saito M, Caceres A, Sung C. IGF-1 activates a cilium-localized noncanonical G?? signaling pathway that regulates cell-cycle progression. Dev Cell. 2013;26:358-68 pubmed publisher..These data suggest that during corticogenesis, a cilium-transduced, noncanonical IGF-1R-G??-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length. ..
- von Weizsäcker E, Strathmann M, Simon M. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA. Biochem Biophys Res Commun. 1992;183:350-6 pubmed..The predicted amino acid sequence of G beta 4 is 79% to 89% identical to the three previously known beta subunits. The diversity of beta gene products may be an important corollary to the functional diversity of G proteins. ..
- Kozasa T, Gilman A. Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem. 1995;270:1734-41 pubmed..Activated alpha z inhibits the activity of type I and type V adenylyl cyclases. It is a somewhat more potent inhibitor of type V adenylyl cyclase than is activated alpha i1. ..
- Ray K, Kunsch C, Bonner L, Robishaw J. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. J Biol Chem. 1995;270:21765-71 pubmed
- Carman C, Barak L, Chen C, Liu Chen L, Onorato J, Kennedy S, et al. Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. J Biol Chem. 2000;275:10443-52 pubmed..Thus, we have (i) identified several specific GRK2 binding determinants for Gbetagamma and phospholipids, and (ii) demonstrated that Gbetagamma binding is the limiting step for GRK2-dependent receptor phosphorylation in cells. ..
- Cuello F, Schulze R, Heemeyer F, Meyer H, Lutz S, Jakobs K, et al. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003;278:7220-6 pubmed..We therefore enriched the Gbeta-phosphorylating activity present in preparations of the retinal G protein transducin and in partially purified G(i/..
- Melliti K, Grabner M, Seabrook G. The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells. J Physiol. 2003;546:337-47 pubmed..Altered G-protein modulation and the consequent reduced presynaptic inhibition may contribute to migraine attacks by favouring a persistent state of hyperexcitability. ..
- Doering C, Kisilevsky A, Feng Z, Arnot M, Peloquin J, Hamid J, et al. A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels. J Biol Chem. 2004;279:29709-17 pubmed..of the Gbetagamma target site on the N-type channel antagonizes subsequent G protein inhibition, albeit only for Gbeta(1)-mediated responses...
- Gao Y, Danciger M, Ozgul R, Gribanova Y, Jacobson S, Farber D. Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease. Mol Vis. 2007;13:287-92 pubmed..This leaves open the possibility of a cooperative involvement of SP4 and GNB1 in the normal function of the retina. ..
- Sun Z, Tang X, Lin F, Chen S. The WD40 repeat protein WDR26 binds G?? and promotes G??-dependent signal transduction and leukocyte migration. J Biol Chem. 2011;286:43902-12 pubmed publisher..Collectively, these experiments identify WDR26 as a novel G??-binding protein that is required for the efficacy of G?? signaling and leukocyte migration. ..
- Levine M, Modi W, O Brien S. Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man. Genomics. 1990;8:380-6 pubmed..These data indicate that there is considerable diversity in the genomic organization of the beta subunit family. ..
- Yan K, Kalyanaraman V, Gautam N. Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. J Biol Chem. 1996;271:7141-6 pubmed..The strong preference of all gamma subunit types for the beta1 subunit type explains the preponderence of this subunit type in most G proteins. ..
- Kinsella B, O Mahony D, Fitzgerald G. The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. J Pharmacol Exp Ther. 1997;281:957-64 pubmed..These results demonstrate that the TP alpha isoform functionally couples with either Gq or G11 in vivo, whether activated by a PG/TXA2 analog or by the F2 isoprostane 8-epi PGF2 alpha. ..
- Nishida K, Kaziro Y, Satoh T. Association of the proto-oncogene product dbl with G protein betagamma subunits. FEBS Lett. 1999;459:186-90 pubmed..c-Jun N-terminal kinase was synergistically activated upon co-expression of Dbl and Gbeta in a dominant-negative Rho-sensitive manner...
- Hollopeter G, Jantzen H, Vincent D, Li G, England L, Ramakrishnan V, et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 2001;409:202-7 pubmed..Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases. ..
- Hippe H, Lutz S, Cuello F, Knorr K, Vogt A, Jakobs K, et al. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. J Biol Chem. 2003;278:7227-33 pubmed..The overexpression of NDPK B, but not its inactive mutant or NDPK A, increased the phosphorylation of Gbeta subunits...
- Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, et al. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell. 2003;114:215-27 pubmed..Although ligand-induced production of PIP(3) is not required for activation of this pathway, PIP(3) appears to localize the activation of Cdc42 by the pathway. ..
- Gao X, Sadana R, Dessauer C, Patel T. Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J Biol Chem. 2007;282:294-302 pubmed..Additional yeast two-hybrid assays showed that the Gbeta(1) subunit also interacts with the N-terminal segments of hACV and human type VI adenylyl cyclase (hACVI)...
- Mylvaganam G, McGee T, Berson E, Dryja T. A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa. Mol Vis. 2006;12:1496-8 pubmed..No likely pathogenic GNB1 mutations have been found in any of 185 unrelated patients with ADRP. This result would be expected if hemizygosity for GNB1 does not result in ADRP or is a rare cause of ADRP. ..
- Díaz Añel A. Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport. Biochem J. 2007;406:157-65 pubmed..In conclusion, we demonstrate that fission of transport carriers at the TGN is dependent on PI-PLCs, specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via DAG production. ..
- Lohmann K, Masuho I, Patil D, Baumann H, Hebert E, Steinrücke S, et al. Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. Hum Mol Genet. 2017;26:1078-1086 pubmed publisher..In conclusion, we demonstrate a pathogenic role of de novo and autosomal dominant mutations in GNB1 as a cause of GDD and provide insights how perturbation in heterotrimeric G protein function contributes to the disease. ..
- Wall M, Coleman D, Lee E, Iñiguez Lluhí J, Posner B, Gilman A, et al. The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 1995;83:1047-58 pubmed..Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade. ..
- Downes G, Gautam N. The G protein subunit gene families. Genomics. 1999;62:544-52 pubmed
- Lowry W, Huang X. G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase. J Biol Chem. 2002;277:1488-92 pubmed..These data support a dual role for Gbetagamma in the activation of Btk signaling function, namely membrane translocation and direct regulation of Btk catalytic activity. ..
- Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed..We suggest that the DRM-H fraction represents a membrane skeleton-associated subset of leukocyte signaling domains. ..
- Brock C, Schaefer M, Reusch H, Czupalla C, Michalke M, Spicher K, et al. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol. 2003;160:89-99 pubmed..e., membrane recruitment is mediated via the noncatalytic p101 subunit, and direct stimulation of G beta gamma with p110 gamma contributes to activation of PI3K gamma. ..
- Sprague R, Bowles E, Olearczyk J, Stephenson A, Lonigro A. The role of G protein beta subunits in the release of ATP from human erythrocytes. J Physiol Pharmacol. 2002;53:667-74 pubmed..Activation of the heterotrimeric G protein, Gi, results in ATP release from erythrocytes. This effect is may be related to the activity of beta subunits associated with this G protein in the human erythrocyte. ..
- Zhou J, Toth P, Miller R. Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3. J Pharmacol Exp Ther. 2003;305:460-6 pubmed
- Richardson M, Kilts J, Kwatra M. Increased expression of Gi-coupled muscarinic acetylcholine receptor and Gi in atrium of elderly diabetic subjects. Diabetes. 2004;53:2392-6 pubmed..7-fold higher levels of Galpha(i2) and twofold higher levels of Gbeta(1). Diabetes does not affect other atrial G proteins, including Galpha(i3,) Galpha(s), Galpha(o), and Gbeta(2)...
- Bonacci T, Ghosh M, Malik S, Smrcka A. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. J Biol Chem. 2005;280:10174-81 pubmed..4-6.7 angstroms of Cys(25). A mutant within the amino terminus of the Gbeta subunit, Gbeta(1)(23-27)gamma(2), activated PLCbeta2 more effectively than wild type, with no significant change ..
- Liu N, Qiao Y, Cai C, Lin W, Zhang J, Miao S, et al. A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK). Front Biosci. 2006;11:1679-89 pubmed..These results provide evidence that HSD-3.8 present in spermatocytes and sperm may participate in spermatogenesis and fertilization process by activating the PKC-dependent ERK1/2 signal transduction pathway. ..
- Geisert E, Lu L, Freeman Anderson N, Templeton J, Nassr M, Wang X, et al. Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice. Mol Vis. 2009;15:1730-63 pubmed..The integration of these data into GeneNetwork provides users with a workbench to test linkages between sequence differences and eye structure and function. ..
- Sondek J, Bohm A, Lambright D, Hamm H, Sigler P. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 1996;379:369-74 pubmed..The structure details interactions between G protein beta- and gamma-subunits and highlights regions implicated in effector modulation for the conserved family of G protein beta gamma dimers. ..
- Huang C, Jan Y, Jan L. Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett. 1997;405:291-8 pubmed..These results are consistent with the idea that the N- and C-terminal domains of the cardiac G protein-gated K+ channel subunits may interact with each other to form higher affinity binding site(s) for G betagamma. ..
- Snow B, Krumins A, Brothers G, Lee S, Wall M, Chung S, et al. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci U S A. 1998;95:13307-12 pubmed..Coexpression of RGS11 with different Gbeta subunits reveals specific interaction between RGS11 and Gbeta5...
- Huang L, Shanker Y, Dubauskaite J, Zheng J, Yan W, Rosenzweig S, et al. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999;2:1055-62 pubmed..We conclude that gustducin heterotrimers transduce responses to bitter and sweet compounds via alpha-gustducin's regulation of phosphodiesterase (PDE) and Gbetagamma's activation of phospholipase C (PLC). ..
- Zhang L, DiLizio C, Kim D, Smyth E, Manning D. The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Mol Pharmacol. 2006;69:1433-40 pubmed..These data establish that G12 and G13 can report differentially potency and efficacy and underscore the relevance of receptor and G protein context. ..
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