GATA-1

Summary

Gene Symbol: GATA-1
Description: GATA binding protein 1 (globin transcription factor 1)
Alias: ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT, GATA-binding factor 1, NF-E1 DNA-binding protein, erythroid transcription factor, erythroid transcription factor 1, globin transcription factor 1, nuclear factor, erythroid 1, transcription factor GATA1
Species: human

Top Publications

  1. doi Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:4367-76. 2010
  2. pmc Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy
    Tohru Fujiwara
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, Madison, 53705, USA
    Mol Cell 36:667-81. 2009
  3. ncbi RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
    Kamaleldin E Elagib
    Department of Pathology, University of Virginia, Charlottesville, VA 22908 0904, USA
    Blood 101:4333-41. 2003
  4. ncbi Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
    Kinuko Ohneda
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Acta Haematol 108:237-45. 2002
  5. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
  6. ncbi Transcription factor GATA-1 and Down syndrome leukemogenesis
    Andrew G Muntean
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Leuk Lymphoma 47:986-97. 2006
  7. pmc Ski negatively regulates erythroid differentiation through its interaction with GATA1
    Nobuhide Ueki
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Mol Cell Biol 24:10118-25. 2004
  8. pmc GATA1 function, a paradigm for transcription factors in hematopoiesis
    Rita Ferreira
    Department of Cell Biology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:1215-27. 2005
  9. pmc Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA
    Blood 107:1570-81. 2006
  10. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003

Detail Information

Publications174 found, 100 shown here

  1. doi Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 115:4367-76. 2010
    ....
  2. pmc Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy
    Tohru Fujiwara
    University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research, Madison, 53705, USA
    Mol Cell 36:667-81. 2009
    ..These results establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a complex network of considerable importance for the control of hematopoiesis...
  3. ncbi RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
    Kamaleldin E Elagib
    Department of Pathology, University of Virginia, Charlottesville, VA 22908 0904, USA
    Blood 101:4333-41. 2003
    ..By contrast, RUNX1-ETO inhibition of GATA function may constitute a potential mechanism for the blockade of erythroid and megakaryocytic differentiation seen in leukemias with t(8;21)...
  4. ncbi Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage
    Kinuko Ohneda
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Acta Haematol 108:237-45. 2002
    ..In addition, recent studies identified several human inherited hematopoietic disorders that are caused by mutations in cis-acting GATA binding motifs or mutations in GATA-1 itself...
  5. ncbi FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
    A P Tsang
    Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 90:109-19. 1997
    ..These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors...
  6. ncbi Transcription factor GATA-1 and Down syndrome leukemogenesis
    Andrew G Muntean
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Leuk Lymphoma 47:986-97. 2006
    ..Future studies to define the entire class of genes dysregulated by mutations in GATA1 will provide important insights into the etiology of these malignancies...
  7. pmc Ski negatively regulates erythroid differentiation through its interaction with GATA1
    Nobuhide Ueki
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Mol Cell Biol 24:10118-25. 2004
    ..We propose that Ski cooperates in the process of transformation in erythroid cells by interfering with GATA1 function, thereby contributing to erythroleukemia...
  8. pmc GATA1 function, a paradigm for transcription factors in hematopoiesis
    Rita Ferreira
    Department of Cell Biology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 25:1215-27. 2005
  9. pmc Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA
    Blood 107:1570-81. 2006
    ....
  10. pmc GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Jeffrey A Grass
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin Medical School, 383 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 100:8811-6. 2003
    ..Such a mechanism is predicted to be critical for the control of hematopoiesis...
  11. pmc Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes
    Stefania Bottardi
    Maisonneuve Rosemont Hospital Research Center, Maisonneuve Rosemont Hospital, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 29:1526-37. 2009
    ..Since the absence of Ikaros also affects GATA-1 recruitment to GATA-2 promoter, we propose that the combinatorial effect of Ikaros and GATA-1 is not restricted to globin gene regulation...
  12. pmc The role of transcriptional activator GATA-1 at human beta-globin HS2
    Youngran Cho
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
    Nucleic Acids Res 36:4521-8. 2008
    ....
  13. pmc Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
    Zahra Kadri
    Department of d Hématologie, Institute Cochin, INSERM U56, CNRS UMR 8104, Université René Descartes Hospital Cochin, Paris, France
    Mol Cell Biol 25:7412-22. 2005
    ..These findings provide the first example of a chain of coupling mechanisms between the binding of erythropoietin to its receptor and GATA-1-dependent gene expression...
  14. pmc A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
    C D Trainor
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Mol Cell Biol 16:2238-47. 1996
    ..We propose that GATApal is important for positive regulation of GATA-1 expression in erythroid cells...
  15. ncbi Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome
    G Xu
    1Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan
    Leukemia 20:1002-8. 2006
    ..Thus, our data indicate that physical interaction and synergy between GATA1 and RUNX1 are retained in DS-AMKL, although it is still possible that increased RUNX1 activity plays a role in the development of leukemia in DS...
  16. pmc Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters
    Francesca Bosè
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
    Mol Cell Biol 26:3942-54. 2006
    ..This may contribute to the functional cooperation between these factors and provide an explanation for the important role of ubiquitous CP2 in the regulation of erythroid genes...
  17. doi Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia
    Rika Kanezaki
    Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Blood 116:4631-8. 2010
    ..001) and lower white blood cell counts (P = .004). Our study indicates that quantitative differences in mutant protein levels have significant effects on the phenotype of TAM and warrants further investigation in a prospective study...
  18. ncbi Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
    L I Zon
    Division of Hematology, Children s Hospital, Boston, MA 02115
    Blood 81:3234-41. 1993
    ..The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins...
  19. ncbi Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis
    Gina Mundschau
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Blood 101:4298-300. 2003
    ..We recently reported that mutations in the transcription factor GATA1 are associated with DS-AMKL...
  20. ncbi Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21
    Liat Rainis
    Department of Pediatric Hemato Oncology, Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel 52621
    Blood 102:981-6. 2003
    ..These findings suggest that acquired intrauterine inactivating mutations in GATA1 and generation of GATA1s cooperate frequently with trisomy 21 in initiating megakaryoblastic proliferation, but are insufficient for progression to AMKL...
  21. pmc Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression
    Michael E Layon
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03756, USA
    J Mol Biol 366:737-44. 2007
    ..These results imply that GATA-1 is sufficient to direct chromatin structure reorganization within the beta-globin LCR and an erythroid pattern of gene expression in the absence of other hematopoietic transcription factors...
  22. pmc GATA-1 forms distinct activating and repressive complexes in erythroid cells
    Patrick Rodriguez
    Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    EMBO J 24:2354-66. 2005
    ..Based on these findings, we suggest a model for the different roles of GATA-1 in erythroid differentiation...
  23. pmc GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription
    Yuan Yeh Kuo
    Institute of Biochemistry and Molecular Biology, National Taiwan University, College of Medicine, Taipei, Taiwan, Republic of China
    Mol Cell Biol 27:4261-72. 2007
    ..These findings illuminate the role of Gfi-1B in GATA-1-mediated transcription in the survival aspect of erythroid cells...
  24. ncbi hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
    M Holmes
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 274:23491-8. 1999
    ..Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser...
  25. ncbi Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    Joshua Wechsler
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 32:148-52. 2002
    ..in GATA1, encoding the essential hematopoietic transcription factor GATA1 (GATA binding protein 1 or globin transcription factor 1)...
  26. doi Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
    Oliver Tunstall-Pedoe
    Department of Haematology, Imperial College London and Imperial Healthcare NHS Trust, London, United Kingdom
    Blood 112:4507-11. 2008
    ..These data indicate that T21 itself profoundly disturbs FL hemopoiesis and they provide a testable hypothesis to explain the increased susceptibility to GATA1 mutations in DS-AMKL and DS-associated transient myeloproliferative disorder...
  27. ncbi Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome
    Marianne E Greene
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, USA
    Blood Cells Mol Dis 31:351-6. 2003
    ..To determine whether mutations in the hematopoietic transcription factor GATA1 are associated with leukemia, we assayed for alterations in the GATA1 gene in bone marrow samples from ..
  28. ncbi Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    Zhe Li
    Division of Hematology Oncology, Childrens Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 37:613-9. 2005
    ....
  29. ncbi GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome
    Johann K Hitzler
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, ON, Canada
    Blood 101:4301-4. 2003
    ..Recently mutations of the gene encoding the hematopoietic transcription factor GATA1 were shown to be specific for AMKL of Down syndrome...
  30. ncbi Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1
    K E Nichols
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA
    Nat Genet 24:266-70. 2000
    ..Our findings underscore the importance of FOG-1:Gata-1 associations in both megakaryocyte and erythroid development, and suggest that other X-linked anaemias or thrombocytopenias may be caused by defects in GATA1...
  31. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..Therefore, activation of the expression of the Epo receptor gene and activation of the erythroid differentiation program are two independent events in normal hematopoiesis...
  32. doi Definitive erythropoiesis in chicken yolk sac
    Hiroki Nagai
    Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Dev Dyn 237:3332-41. 2008
    ..It remains unclear whether yolk sac derived hematopoietic progenitors that do not undergo erythropoiesis in the yolk sac may take up intraembryonic niches and contribute to erythropoietic stem cell population after hatching...
  33. ncbi Real-time monitoring of stress erythropoiesis in vivo using Gata1 and beta-globin LCR luciferase transgenic mice
    Mikiko Suzuki
    Graduate School of Comprehensive Human Sciences, the Center for Tsukuba Advanced Research Alliance TARA, Japan Science and Technology Corporation, University of Tsukuba
    Blood 108:726-33. 2006
    ....
  34. doi Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
    ..This surprising finding indicates that the primitive erythroid lineage is indeed mammalian, rather than non-mammalian, in character...
  35. ncbi Uroporphyrinogen III synthase. An alternative promoter controls erythroid-specific expression in the murine gene
    G I Aizencang
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:2295-304. 2000
    ..Thus, housekeeping and erythroid-specific transcripts are expressed from alternative promoters of a single mouse URO-synthase gene...
  36. ncbi GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia
    Yubin Ge
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    J Natl Cancer Inst 97:226-31. 2005
    ....
  37. pmc Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development
    Kinuko Ohneda
    Department of Pharmacy, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki 370 0033, Japan
    J Biol Chem 284:30187-99. 2009
    ..5-kbp region of the Gata1 gene. These data provide compelling evidence that the G(5) string is necessary for Gata1 gene expression in vivo and ZBP-89 is the functional trans-acting factor for this cis-acting region...
  38. ncbi Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    Lucia Centurione
    Department of Biomorphology, University G D Annunzio, Chieti, Italy
    Blood 104:3573-80. 2004
    ..We suggest that such an increased and pathologic neutrophil emperipolesis may represent one of the mechanisms leading to myelofibrosis by releasing fibrogenic MK cytokines and neutrophil proteases in the microenvironment...
  39. pmc Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression
    Roy Drissen
    Medical Research Council Molecular Haematology Unit, John Radcliffe Hospital, Oxford, UK
    Blood 115:3463-71. 2010
    ..5 and mHS-25/6 collectively regulate erythroid Gata1 expression, demonstrating lineage-specific differences in Gata1 cis-element use important for development of these 2 cell types...
  40. ncbi fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis
    Pascal Songhet
    University of Cologne, Institute for Developmental Biology, Koln, Germany
    Dev Dyn 236:633-43. 2007
    ..As its knockdown in zebrafish changes expression of gata1, a gene involved in hematopoietic stem cell decisions, FGF1 should be considered to play a role in the pathogenesis of del(5q) syndrome...
  41. pmc Structural and functional analysis of the Entamoeba histolytica EhrabB gene promoter
    Mónica Romero-Díaz
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, A, P, 14 740 México, DF 07360, Mexico
    BMC Mol Biol 8:82. 2007
    ..However, the transcription regulation in this parasite is poorly understood...
  42. ncbi Induction of differentiation of avian erythroblastosis virus-transformed erythroblasts by the protein kinase inhibitor H7: analysis of the transcription factor EF1
    R H Nicolas
    Chester Beatty Laboratories, Institute of Cancer Research, London
    Cell Growth Differ 2:129-35. 1991
    ..mechanism by which the differentiation occurs, we have characterized and analyzed the levels of the erythroid transcription factor EF1, originally described as a factor binding to the beta H-globin promoter...
  43. pmc Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development
    Elias T Zambidis
    Division of Immunology and Hematopoiesis, Sidney Kimmel comprehensive Cancer Center at John Hokins, The John Hopkins School of Medicine, Baltimore, MD, USA
    Blood 106:860-70. 2005
    ....
  44. pmc Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium
    Craig H Pratt
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Vis 14:1414-28. 2008
    ..Thus, the purpose of the present study was to identify TFs that may play a role in this process...
  45. pmc Differential localization of P-selectin and von Willebrand factor during megakaryocyte maturation
    M Zingariello
    Department of Biomorphology, University of Chieti, Chieti, Italy
    Biotech Histochem 85:157-70. 2010
    ..These observations support the hypothesis that P-selectin and von Willebrand factor may ensure differential release of the alpha-granule content in response to external stimuli...
  46. doi Human parvovirus B19 infection and autoimmunity
    Claudio Lunardi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Autoimmun Rev 8:116-20. 2008
    ..Moreover the VP peptide shares similarity with the transcription factor GATA1 that plays an essential role in megakaryopoiesis and in erythropoiesis...
  47. ncbi Human uroporphyrinogen-III synthase: genomic organization, alternative promoters, and erythroid-specific expression
    G Aizencang
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genomics 70:223-31. 2000
    ..Thus, human URO-synthase expression is regulated during erythropoiesis by an erythroid-specific alternative promoter...
  48. doi Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA
    Darren L Bates
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309 0215, USA
    J Mol Biol 381:1292-306. 2008
    ..These findings significantly advance our understanding of the structure and function of GATA and provide an important framework for further investigating the in vivo mechanisms of GATA-dependent gene regulation...
  49. pmc Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
    Andrew G Muntean
    Ben May Institute for Cancer Research, Univeristy of Chicago, IL, USA
    Blood 106:1223-31. 2005
    ..These studies show that GATA-1 is required for both normal regulation of proliferation and terminal maturation of megakaryocytes, and further, that these functions can be uncoupled by mutations in GATA1...
  50. ncbi IFN consensus sequence binding protein (Icsbp) is critical for eosinophil development
    Maja Milanovic
    Leibniz Forschungsinstitut fuer Molekulare Pharmakologie, Berlin, Germany
    J Immunol 181:5045-53. 2008
    ..The transcription factor Gata1, crucial for eosinophil development, is reduced expressed in committed eosinophil progenitors in wells ..
  51. ncbi The role of phospholipase C gamma 1 in primitive hematopoiesis during zebrafish development
    Alvin C H Ma
    Division of Hematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Exp Hematol 35:368-73. 2007
    ..However, its role in hematopoiesis during embryonic development is currently unclear. In this study, we examined this issue using morpholino (MO) gene knockdown in zebrafish embryos..
  52. ncbi Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
    ..Platelets derived from mice lacking the transcription factor GATA1 show similar defects, probably as a direct consequence of absent beta1-tubulin...
  53. ncbi GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells)
    M Jasinski
    Division of Hematology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 98:2248-55. 2001
    ..These animals will be valuable to further investigate the consequences of GPI-anchor deficiency on erythroid/megakaryocytic cells...
  54. pmc The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription
    Osamu Tanabe
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2832-44. 2007
    ....
  55. pmc Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish
    Ting Xi Liu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Exp Hematol 35:230-9. 2007
    ..We investigated the role of CCAAT enhancer-binding protein-alpha (C/EBPalpha) during zebrafish embryonic blood development...
  56. pmc CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin
    Maria Verrucci
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    J Cell Physiol 225:490-9. 2010
    ..These results indicate that Aplidin effectively alters the natural history of myelofibrosis in Gata1(low) mice and suggest this drug as candidate for clinical evaluation in PMF...
  57. pmc Removal of the spleen in mice alters the cytokine expression profile of the marrow micro-environment and increases bone formation
    Fabrizio Martelli
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Ann N Y Acad Sci 1176:77-86. 2009
    ..These results confirm the role of megakaryocytes as regulator of bone formation in mice and suggest that a cross-talk between the spleen and marrow may regulate the total numbers of hemopoietic niches present in an animal...
  58. doi Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    Dani Bercovich
    Human Molecular Genetics and Pharmacogenetics Laboratory, Migal Galilee Biotechnology Centre, Kiryat Shmona, and Tel Hai Academic College, Israel
    Lancet 372:1484-92. 2008
    ..We tested the hypothesis that mutations in JAK2 might be a common molecular event in acute lymphoblastic leukaemia associated with Down's syndrome...
  59. doi A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera
    Alvin C H Ma
    Department of Medicine, The University of Hong Kong, Hong Kong
    Exp Hematol 37:1379-1386.e4. 2009
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  60. doi Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes
    Paul S Hartley
    Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Br J Haematol 146:185-92. 2009
    ..These findings imply that circadian clock gene expression regulates platelet turnover in mammals...
  61. ncbi DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin
    S Ottolenghi
    Dipartimento di Genetica e di Biologia dei Microrganismi Università degli Studi di Milano, Italy
    Hemoglobin 13:523-41. 1989
    ..might operate and HPFH might additionally be related to loss of binding to the distal CCAAT box region of either NFE1 (-117 HPFH) or of the ubiquitous CCAAT displacement protein-CDP (13 nucleotides deletion)...
  62. pmc Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish
    Lisa J McReynolds
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Hematol 36:1604-1615. 2008
    ..Functions for this pathway in adult hematopoiesis have been challenging to probe in other models...
  63. ncbi Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2
    Tomo Terano
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
    Exp Hematol 33:641-51. 2005
    ..To elucidate the functional role of two LIM domains in LMO2, we introduced deletion or mutation in each of the LIM domains and analyzed their phenotypic effects on the hematopoietic system when overexpressed in vivo or in vitro...
  64. ncbi Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements
    Astrid Borchert
    Institute of Biochemistry, Humboldt University Medical School Charité, Monbijoustrasse 2, 10117 Berlin, Germany
    J Biol Chem 278:2571-80. 2003
    ..The decision, which GPx isoform is expressed in a given cell, appears to be made by alternative splicing of a joint primary transcript...
  65. ncbi The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily
    D L Lin
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, NY 14642, USA
    Endocrine 8:123-34. 1998
    ..3...
  66. pmc The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice
    Ramiro E Toribio
    Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon Tharp St, Columbus, OH 43210, USA
    FASEB J 24:1947-57. 2010
    ..The down-regulation of Runx1, Runx2, and Sox9 indicates that PTHrP is a modulator of transcriptional activation during stem cell commitment...
  67. ncbi Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome
    David S Brink
    Department of Pathology, Saint Louis University School of Medicine, Saint Louis, MO 63104 1003, USA
    Adv Anat Pathol 13:256-62. 2006
    ..The pathogenetic role of trisomy 21 in DS-TL is unclear. Though indications for chemotherapy in DS-TL have not been firmly established, the blasts of DS-TL are sensitive to low-dose cytosine arabinoside...
  68. ncbi [Oncogenes and leukemia: history and perspectives]
    Sylvie Gisselbrecht
    Département d Hématologie de l Institut Cochin, INSERM U 567, CNRS UMR 8104, bâtiment Gustave Roussy, 27, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 19:201-10. 2003
    ..Treatment of leukemia could therefore benefit from new therapeutic approaches targeting the function of specific oncogene products as already demonstrated for CML and acute promyelocytic leukemia...
  69. ncbi Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development
    Genevieve Kinna
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mech Dev 123:277-87. 2006
    ..Hence, the primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development...
  70. doi Mosaic Down syndrome-associated acute myeloid leukemia does not require high-dose cytarabine treatment for induction and consolidation therapy
    Kazuko Kudo
    Division of Hematology and Oncology, Shizuoka Children s Hospital, Aoi ku, Shizuoka, Japan
    Int J Hematol 91:630-5. 2010
    ..7%, respectively. Our retrospective study reveals that patients with mosaic DS and AMKL have a good prognosis. Reduction in intensity may work in patients with mosaic DS as well as with AML-DS...
  71. ncbi Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis
    Ryuki Hanaoka
    Laboratory of Developmental Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto, 606 8501, Japan
    Genes Cells 11:293-303. 2006
    ....
  72. pmc Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6
    Jian Xu
    Children s Hospital Boston, Massachusetts 02115, USA
    Genes Dev 24:783-98. 2010
    ..Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the beta-globin locus...
  73. ncbi Fractionation of mature eosinophils in GATA-reporter transgenic mice
    Kibom Kim
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Tohoku J Exp Med 220:127-38. 2010
    ..This study, therefore, proposes a useful means to study the experimental allergic and inflammatory systems...
  74. ncbi Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature
    Claudio Sandoval
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Blood Cancer 44:85-91. 2005
    ..Transient leukemia in trisomy 21 mosaicism recapitulates the condition observed in constitutional trisomy 21 at the biological and clinical levels. Infants should be followed for the development of acute leukemia...
  75. pmc Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
    Christiane L Belele
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:5162-72. 2009
    The transcription factor Gata1 is required for the development of erythrocytes and megakaryocytes...
  76. doi The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis
    Laura M Pillay
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Dev Biol 340:306-17. 2010
    ..Our study conclusively demonstrates that Meis1 and Pbx act to specify the erythropoietic cell lineage and inhibit myelopoiesis...
  77. pmc Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer
    Kurtis Eisermann
    School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    BMC Genomics 9:337. 2008
    ..To rapidly identify coordinately expressed prostate cancer growth control genes that may be regulated by WT1, we used an in silico approach...
  78. ncbi Homotypic signalling regulates Gata1 activity in the erythroblastic island
    Laura Gutierrez
    Erasmus MC, Department of Cell Biology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Development 131:3183-93. 2004
    ..This study demonstrates the importance of intercellular signalling in regulating Gata1 activity and that this homotypic signalling between erythroid cells is crucial to normal differentiation...
  79. doi Co-culture of carp (Cyprinus carpio) kidney haematopoietic cells with feeder cells resulting in long-term proliferation of T-cell lineages
    Fumihiko Katakura
    Laboratory of Fish Pathology, Department of Veterinary Medicine, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 131:127-36. 2009
    ..These results indicate that multiple blood cells developed in the primary culture and then T-cell lineages dominantly proliferated after several passages...
  80. doi The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs
    Jun Takai
    Department of Medical Biochemistry and
    Blood 122:3450-60. 2013
    ..These results indicate that the 3.2-kb interspacing sequences inactivate Gata1 by maintaining DNA-methylation in the HSCs. ..
  81. ncbi Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro
    Bi Fong Lin
    Department of Biochemical Science and Technology, Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taiwan, Republic of China
    Int Immunopharmacol 5:711-22. 2005
    ..After sequentially purifying WASWE, a novel immuno-stimulating protein (GF1) with a molecular weight of 313 kDa was obtained...
  82. pmc Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice
    Anna Nilton
    Wallenberg Laboratory, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e70022. 2013
    ..The transcription factor zinc finger protein 148 (Zfp148) interacts with the hematopoietic transcription factor Gata1 and has been implicated to play an important role in primitive and definitive hematopoiesis in zebra ..
  83. ncbi The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
    Carrie A Adelman
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 129:539-49. 2002
    ....
  84. pmc Dynamic Analysis of Gene Expression and Genome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors
    Gillian May
    Stem Cell Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Cell Stem Cell 13:754-68. 2013
    ..This rubric exemplifies the utility of this cross-platform resource for deconvoluting the complexity of transcriptional programs controlling stem/progenitor cell fate in hematopoiesis. ..
  85. pmc Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1
    Stephan Kadauke
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cell 150:725-37. 2012
    ..We investigated whether transcription factor GATA1 plays a role in transmitting hematopoietic gene expression programs through mitosis when transcription ..
  86. doi Pulsatile atheroprone shear stress affects the expression of transient receptor potential channels in human endothelial cells
    Florian Thilo
    Department of Nephrology, Charite Campus Benjamin Franklin, Berlin, Germany
    Hypertension 59:1232-40. 2012
    ....
  87. doi GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ1
    Yasushi Ishijima
    Faculty of Pharmacy, Department of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui machi, Takasaki, Gunma 370 0033, Japan
    Genes Cells 17:285-301. 2012
    ..These data indicate that PLC-γ1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-γ1...
  88. ncbi ERF, an ETS-related transcriptional repressor, can induce erythroid differentiation
    Meropi Athanasiou
    Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Anticancer Res 23:2143-53. 2003
    ..The effect of ERF is similar to the one shown for ETS1 and opposite to the FLI1 function in these cells, suggesting that several ets genes may play key roles in hematopoietic differentiation...
  89. doi Patterns of angiogenic and hematopoietic gene expression during brown trout embryogenesis
    Julia Marschallinger
    Department of Organismic Biology, Division of Zoology and Functional Anatomy, University of Salzburg, Salzburg, Austria
    J Exp Zool B Mol Dev Evol 310:479-91. 2008
    ..The results supplement and validate previous, now historical morphological work in salmonids, thus aiding the elucidation of a comprehensive general scheme of angiogenic and hematopoietic development in the teleost embryo...
  90. doi Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation
    Miao Li
    Department of Medical Genetics, China Medical University, No92, Bei Er Road, Shenyang 110001, China
    Int J Biochem Cell Biol 41:872-8. 2009
    ..These findings indicate that TSA induces hWNK4 expression, at least in part, by increasing GATA-1 acetylation, and thereby its binding to the GATA-1 responsive element, within the hWNK4 promoter...
  91. ncbi RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain
    J M Derry
    Howard Hughes Medical Insitute, Stanford University Medical Center, CA 94305, USA
    Hum Mol Genet 4:2307-11. 1995
    ..The homology of RMB3 in both sequence and size to an RNA binding protein from maize, AAIP , suggests that it functions in a fundamental pathway conserved from plants to mammals...
  92. ncbi Down syndrome, drug metabolism and chromosome 21
    Jeffrey W Taub
    Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
    Pediatr Blood Cancer 44:33-9. 2005
    ..Microarray technology should lead to the identification of additional gene targets linked to the treatment response of specific cytogenetic leukemia subgroups...
  93. ncbi Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
    Clive S McKimmie
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 181:3353-63. 2008
    ..These data therefore alter our models of in vivo D6 function and suggest possible discrete, and novel, roles for D6 on lymphatic endothelial cells and leukocytes...
  94. doi Myeloid proliferation without GATA1 mutations in a fetus with Down syndrome presenting in utero as a pericardial effusion
    Anne Laure Rougemont
    Division of Clinical Pathology, Geneva University Hospitals, 1211 Geneva, Switzerland
    Pediatr Dev Pathol 13:423-6. 2010
    ..We present here a 2nd case, which further supports the hypothesis that hyperproliferation of megakaryocytes in a subset of Down syndrome patients may be initiated by events other than GATA1 mutations...
  95. pmc Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells
    N Rekhtman
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genes Dev 13:1398-411. 1999
    ..1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation...
  96. pmc Uroporphyrinogen III synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause congenital erythropoietic porphyria
    C Solis
    Department of Human Genetics, Mount Sinai School of Medicine, Fifth Avenue at 100th Street, New York, NY 10029, USA
    J Clin Invest 107:753-62. 2001
    ....
  97. doi Molecular pharmacological basis of the YiSui ShenXu Granule in beta-thalassemia therapy
    Chong Zhang
    Molecular Biology Laboratory of Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    J Ethnopharmacol 120:437-41. 2008
    ..To study the molecular pharmacological basis of the YiSui ShenXu Granule, a complex prescription of the Chinese traditional medicine used to treat beta-thalassemia...
  98. pmc A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes
    Susan E Lyons
    National Human Genome Research Institute, National Institutes of Health, Building 49, Room 3A18, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:5454-9. 2002
    ....
  99. pmc LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis
    Takahiro Maeda
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 17:527-40. 2009
    ..Thus, our data define a key transcriptional cascade for effective erythropoiesis, whereby GATA-1 suppresses BIM-mediated apoptosis via LRF...
  100. pmc Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain
    Eri Kobayashi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 285:773-83. 2010
    ..The present study demonstrates that the IE exon is instrumental to adult erythropoiesis by regulating the proper level of transcription and selecting the correct transcription start site of the Gata1 gene...

Research Grants78

  1. Mechanisms of Leukemogenesis in Down Syndrome
    John Crispino; Fiscal Year: 2007
    ..We recently demonstrated that the hematopoietic transcription factor GATA1 is mutated in nearly all cases of both TMD and DS-AMKL...
  2. Mechanisms of Leukemogenesis in Down Syndrome
    John Crispino; Fiscal Year: 2009
    ..We recently demonstrated that the hematopoietic transcription factor GATA1 is mutated in nearly all cases of both TMD and DS-AMKL...
  3. Mechanisms of Leukemogenesis in Down Syndrome
    John D Crispino; Fiscal Year: 2010
    ..We recently demonstrated that the hematopoietic transcription factor GATA1 is mutated in nearly all cases of both TMD and DS-AMKL...
  4. Molecular and Pharmacologic Correletes of Acute Myeloid Leukemia in Down Syndrome
    JEFFREY TAUB; Fiscal Year: 2007
    ....
  5. Molecular and Pharmacologic Correletes of Acute Myeloid Leukemia in Down Syndrome
    JEFFREY WARREN TAUB; Fiscal Year: 2010
    ....
  6. Molecular and Pharmacologic Correletes of Acute Myeloid Leukemia in Down Syndrome
    JEFFREY TAUB; Fiscal Year: 2009
    ....
  7. Mechanisms of Leukemogenesis in Down Syndrome
    John Crispino; Fiscal Year: 2006
    ....
  8. NOVEL REGULATORS OF LATE STAGE BONE MARROW ERYTHROBLAST DEVELOPMENT
    Don Wojchowski; Fiscal Year: 2010
    ..Proposed work promises to discover and characterize novel regulators of erythroblast and RBC production as potentially drugable E3 ligase complexes;and as a new RBC progenitor niche in bone marrow with unique expansion potential. ..
  9. Role of the BMP4 Dependent Stress Erythropoiesis Pathway in Short-Term Radioprote
    ROBERT FRANK PAULSON; Fiscal Year: 2010
    ..The information gathered from this work will provide key basic information for the development of new therapies for anemia and other blood diseases. ..
  10. Transcriptional Regulatory Networks Active in Terminal Erythroid Differentiation
    Shilpa Hattangadi; Fiscal Year: 2007
    ..I plan to understand this program in the biology of red blood cell development, in hopes of discovering new treatments for these disorders. ..
  11. Control of lymphatic vessel growth and development by platelets
    Mark L Kahn; Fiscal Year: 2010
    ..Since both lymphatic vessel defects and platelet activation are responsible for human vascular diseases we expect these studies to provide new insight into human disease. ..
  12. Transcriptional Networks Controlling Erythroid Differentiation
    Gerd A Blobel; Fiscal Year: 2010
    ..Progress is this area promises novel approaches to treat blood-related disorders including leukemias and anemias. ..
  13. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh Shivdasani; Fiscal Year: 2007
    ..To facilitate the Aims of this project, we also propose to adapt the method to abrogate expression of endogenous genes. We expect the collective results of our studies to advance current understanding of how MKs produce blood platelets. ..
  14. MLL in Hematopoiesis and Leukemia in the Zebrafish Model
    Carolyn A Felix; Fiscal Year: 2010
    ..The exploitation of zebrafish to model the functions of human MLL in the regulation of normal and malignant blood cell development will streamline future inroads to new molecularly targeted therapies for patients with MLL leukemia. ..
  15. Differentiation of Th2 cytokine-producing innate cells
    Hua Huang; Fiscal Year: 2009
    ..For diseases such as allergic inflammation, asthma, parasitic infection, and other immune dysregulations, our findings could lead to more effective treatments. ..
  16. Transcription Factor GATA-1 in Erythro-Megakaryocytic Development and Leukemia
    Mitchell Weiss; Fiscal Year: 2007
    ....
  17. The 4th International Conference on GATA Factors and Human Disease
    JAMES ENGEL; Fiscal Year: 2007
    ....
  18. Mechanisms of erythroid differentiation
    PAUL NEY; Fiscal Year: 2007
    ..Irs2 activates some of the same signaling pathways as the distal Epor. So, we will determine whether Irs2 is functionally redundant with the distal Epor in normal erythroid cells. ..
  19. NF-E2 BINDING SITES AND GLOBIN GENE REGULATION
    PAUL NEY; Fiscal Year: 2002
    ..To identify molecules that interact with these motifs, we propose yeast one/two-hybrid screens. Results from these experiments should yield important insights into the regulation of globin gene expression. ..
  20. Phamacological modulation of epigenetic changes in AML
    Guido Marcucci; Fiscal Year: 2010
    ..This knowledge will be used to design more effective treatment for AML . ..
  21. A Comparative Approach to Globin Regulation/Thalassemia
    Leonard Zon; Fiscal Year: 2003
    ..Our studies should provide a better understanding of the basic biology of hemoglobin production and may have a therapeutic impact on patients with thalassemia, sickle cell anemia, and hemochromatosis. ..
  22. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2000
    ..The proposed study will provide new insights into the biology of hematopoiesis in both normal and pathologic states such as anemia and hemoglobinopathies, and will be useful for bone marrow transplantation and gene therapy. ..
  23. PHARMACOLOGICAL MODULATION OF EPIGENETIC CHANTGES IN AML
    Guido Marcucci; Fiscal Year: 2006
    ..e., valproic acid); 2) to perform pharmacokinetic and pharmacodynamic studies of these agents that will allow correlations of drug plasma levels, chromatin changes and gene re-expression with toxicity and disease response. ..
  24. Phamacological modulation of epigenetic changes in AML
    Guido Marcucci; Fiscal Year: 2009
    ..This knowledge will be used to design more effective treatment for AML . ..
  25. EMBRYONIC HEMATOPOIESIS
    Leonard Zon; Fiscal Year: 2005
    ..These isolated genes may be of therapeutic value for patients with anemia or leukemia, as well as for patients undergoing marrow transplantation or gene therapy. ..
  26. Cancer Biology in the Zebrafish
    Leonard Zon; Fiscal Year: 2007
    ..These studies should provide new insight into the vertebrate cell cycle and cancer biology, and may delineate pharmaceutical targets for patients with cancer. ..
  27. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
  28. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..Some people require surgery or blood transfusions to treat the anemia. This application studies the what, why, and how of abnormalities of the lining of the red blood cell that cause the anemia. ..
  29. MOLECULAR BIOLOGY OF HUMAN ERYTHROCYTE ALPHA-SPECTRIN
    Patrick Gallagher; Fiscal Year: 2007
    ..These studies will provide important insights into the role of spectrin in normal and disease states. ..
  30. MOLECULAR BIOLOGY OF HUMAN ERYTHROCYTE ALPHA-SPECTRIN
    Patrick Gallagher; Fiscal Year: 2003
    ..These studies will provide important insights into our studies of the role of a-spectrin in normal and disease states. ..