GAS6

Summary

Gene Symbol: GAS6
Description: growth arrest specific 6
Alias: AXLLG, AXSF, growth arrest-specific protein 6, AXL receptor tyrosine kinase ligand, AXL stimulatory factor
Species: human
Products:     GAS6

Top Publications

  1. Shankar S, O Guin K, Kim M, Varnum B, Lemke G, Brosnan C, et al. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci. 2006;26:5638-48 pubmed
    Growth arrest-specific protein 6 (gas6) activity is mediated through the receptor tyrosine kinase family members Axl, Rse, and Mer, all of which are expressed in human oligodendrocytes...
  2. Jiang L, Liu C, Yang Q, Wang P, Zhang W. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. Am J Clin Pathol. 2009;131:738-43 pubmed publisher
    Growth arrest-specific gene 6 (GAS6) encodes a vitamin K-dependent protein that regulates inflammation, angiogenesis, and atherosclerotic plaque formation. The level of GAS6 expression is associated with plaque stability and stroke...
  3. Clauser S, Meilhac O, Bieche I, Raynal P, Bruneval P, Michel J, et al. Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques. Thromb Haemost. 2012;107:140-9 pubmed publisher
    Vitamin K-dependent protein Gas6 (growth-arrest specific gene 6) plays a role in vascular smooth muscle cell (VSMC) survival and migration, as well as in endothelium and leukocyte activation, and could therefore be involved in ..
  4. Ekman C, Jönsen A, Sturfelt G, Bengtsson A, Dahlback B. Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus. Rheumatology (Oxford). 2011;50:1064-9 pubmed publisher
    ..Growth arrest-specific protein 6 (Gas6) and its receptor Axl are known to regulate inflammation and may be implicated in lupus pathogenesis...
  5. Hurtado B, Abasolo N, Munoz X, Garcia N, Benavente Y, Rubio F, et al. Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. Thromb Haemost. 2010;104:592-8 pubmed publisher
    ..and recent studies suggest that pathways initiated by the interaction of the plasma vitamin K-dependent protein GAS6 with the tyrosine kinase receptors TYRO3, AXL and MERTK (TAM) may have a relevant role in atherogenesis...
  6. Hung Y, Lee C, Chu N, Shieh Y. Plasma protein growth arrest-specific 6 levels are associated with altered glucose tolerance, inflammation, and endothelial dysfunction. Diabetes Care. 2010;33:1840-4 pubmed publisher
    Plasma protein growth arrest-specific 6 (Gas6) is important to the inflammatory process and is involved in the development of diabetic renal and vascular complications...
  7. Shiozawa Y, Pedersen E, Patel L, Ziegler A, Havens A, Jung Y, et al. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia. 2010;12:116-27 pubmed
    ..study, we demonstrate that the binding of PCa to annexin II induces the expression of the growth arrest-specific 6 (GAS6) receptors AXL, Sky, and Mer, which, in the hematopoietic system, induce dormancy...
  8. Prieto A, Weber J, Lai C. Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system. J Comp Neurol. 2000;425:295-314 pubmed
    ..The molecule Gas6 (for growth arrest-specific gene-6) has been shown to activate each of these receptors...
  9. Varnum B, Young C, Elliott G, Garcia A, Bartley T, Fridell Y, et al. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature. 1995;373:623-6 pubmed
    ..We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6)...

More Information

Publications79

  1. Uehara S, Handa H, Gotoh K, Tomita H, Sennshuu M. Plasma concentrations of growth arrest-specific protein 6 and protein S in patients with acute pancreatitis. J Gastroenterol Hepatol. 2009;24:1567-73 pubmed publisher
    ..The aim of the present study was to clarify the changes in plasma concentrations of growth arrest-specific protein 6 (Gas6) and protein S (PS) in patients with mild or severe acute pancreatitis (AP)...
  2. Gheita T, Bassyouni I, Bassyouni R. Plasma concentrations of growth arrest specific protein 6 and the soluble form of its tyrosine kinase receptor Axl in patients with systemic lupus erythematosus and Behçets disease. J Clin Immunol. 2012;32:1279-86 pubmed publisher
    The aim of the present study was to investigate plasma concentrations of Gas6 and its soluble tyrosine kinase receptor sAxl in Systemic lupus erythematosus (SLE) and Behçets disease (BD) patients and to correlate those levels with ..
  3. Stitt T, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell. 1995;80:661-70 pubmed
    ..These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any known function...
  4. Hasanbasic I, Rajotte I, Blostein M. The role of gamma-carboxylation in the anti-apoptotic function of gas6. J Thromb Haemost. 2005;3:2790-7 pubmed
    b>Gas6 is a novel member of the vitamin K-dependent family of gamma-carboxylated proteins and is a ligand for the receptor tyrosine kinase Axl. Gas6-Axl interactions have been shown to mediate cell survival in vascular endothelium...
  5. Ekman C, Stenhoff J, Dahlback B. Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J Thromb Haemost. 2010;8:838-44 pubmed publisher
    The vitamin K-dependent Gas6 protein (product of growth arrest specific gene 6) binds to, and activates the TAM receptor tyrosine kinases Tyro3, Axl and Mer...
  6. Sun W, Fujimoto J, Tamaya T. Coexpression of Gas6/Axl in human ovarian cancers. Oncology. 2004;66:450-7 pubmed
    b>Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, was identified as a ligand for the Axl/Sky family of receptor tyrosine kinases...
  7. Park I, Giovenzana C, Hughes T, Yu J, Trotta R, Caligiuri M. The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. Blood. 2009;113:2470-7 pubmed publisher
    ..In this study, we assessed whether the receptor tyrosine kinase Axl and its ligand, Gas6, are involved in IL-15-mediated human NK differentiation from CD34(+) hematopoietic progenitor cells (HPCs)...
  8. Angelillo Scherrer A, de Frutos P, Aparicio C, Melis E, Savi P, Lupu F, et al. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nat Med. 2001;7:215-21 pubmed
    The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown...
  9. Lee C, Chu N, Shieh Y, Hung Y. The growth arrest-specific 6 (Gas6) gene polymorphism c.834+7G>A is associated with type 2 diabetes. Diabetes Res Clin Pract. 2012;95:201-6 pubmed publisher
    The plasma protein growth arrest-specific 6 (Gas6) is important to the inflammatory process and involved in the development of diabetic renal and vascular complications...
  10. Alciato F, Sainaghi P, Sola D, Castello L, Avanzi G. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages. J Leukoc Biol. 2010;87:869-75 pubmed publisher
    b>GAS6 protein has been described to be involved in immune modulation in vitro and in vivo. Some of these effects are probably mediated through the involvement of monocytes/macrophages...
  11. Hsiao F, Lin Y, Hsieh P, Chu N, Shieh Y, Hsieh C, et al. Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. J Clin Endocrinol Metab. 2013;98:E267-74 pubmed publisher
    Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes...
  12. Laurance S, Lemarié C, Blostein M. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv Nutr. 2012;3:196-203 pubmed publisher
    b>Gas6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. Gas6 has a high structural homology with the natural anticoagulant protein S, sharing the same modular composition...
  13. Munoz X, Obach V, Hurtado B, de Frutos P, Chamorro A, Sala N. Association of specific haplotypes of GAS6 gene with stroke. Thromb Haemost. 2007;98:406-12 pubmed
    The product of the growth arrest-specific gene 6 (GAS6), a ligand for tyrosine kinase receptors, is a vitamin K-dependent protein, structurally related to anticoagulant protein S...
  14. Mishra A, Wang J, Shiozawa Y, McGee S, Kim J, Jung Y, et al. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Mol Cancer Res. 2012;10:703-12 pubmed publisher
    ..Previous data from our laboratory indicate that Axl and its ligand growth arrest-specific 6 (GAS6) may play a role in establishing metastatic dormancy in the bone marrow microenvironment...
  15. Son B, Kozaki K, Iijima K, Eto M, Kojima T, Ota H, et al. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circ Res. 2006;98:1024-31 pubmed
    ..apoptosis, focusing in particular on regulation of the survival pathway mediated by growth arrest-specific gene 6 (Gas6), a member of the vitamin K-dependent protein family, and its receptor, Axl...
  16. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, et al. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem. 1996;271:30022-7 pubmed
    ..The product of growth arrest-specific gene 6 (Gas6), structurally homologous to the anticoagulant protein S, was recently identified as the ligand for Axl and Sky, ..
  17. Shiozawa Y, Pedersen E, Taichman R. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp Hematol. 2010;38:132-40 pubmed publisher
    ..In this study, we examined the roles of growth arrest-specific-6 (GAS6)/Mer axis in the interactions between E2A/PBX1-positive B-cell precursor ALL cells and the osteoblastic niche in ..
  18. Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P, et al. Identification of Gas6 as a growth factor for human Schwann cells. J Neurosci. 1996;16:2012-9 pubmed
    ..We find that Gas6, a ligand for the Axl and Rse/Tyro3 receptor protein tyrosine kinase family, stimulates human Schwann cell growth, ..
  19. Burnier L, Borgel D, Angelillo Scherrer A, Fontana P. Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects. J Thromb Haemost. 2006;4:2283-4 pubmed
  20. Ekman C, Gottsäter A, Lindblad B, Dahlback B. Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia. Clin Biochem. 2010;43:873-6 pubmed publisher
    ..b>Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl...
  21. Gallicchio M, Mitola S, Valdembri D, Fantozzi R, Varnum B, Avanzi G, et al. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. Blood. 2005;105:1970-6 pubmed
    b>GAS6, the product of a growth arrest specific (GAS) gene, is the ligand of the tyrosine kinase receptor Axl...
  22. Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol. 1993;13:4976-85 pubmed
    ..Schneider, R. M. King, and L. Philipson, Cell 54:787-793, 1988). The detailed analysis of one of them, gas6, is reported here, gas6 mRNA (2.6 kb) is abundantly expressed in serum-starved (48 h in 0...
  23. Goruppi S, Ruaro E, Schneider C. Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts. Oncogene. 1996;12:471-80 pubmed
    ..b>gas6 product (Gas6) is a secreted protein that was identified as the ligand for the tyrosine kinase receptor Axl...
  24. Gustafsson A, Martuszewska D, Johansson M, Ekman C, Hafizi S, Ljungberg B, et al. Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival. Clin Cancer Res. 2009;15:4742-9 pubmed publisher
    ..Therefore, we conducted this study to determine the expression of Axl and its ligand Gas6 in various renal cell carcinoma (RCC) types and in oncocytoma...
  25. Sainaghi P, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi G. Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. J Cell Physiol. 2005;204:36-44 pubmed
    ..The ligand of Axl, Gas6, is a 75 KDa multimodular protein with an N-terminal gamma-carboxy-glutamic acid that is essential for binding...
  26. Godowski P, Mark M, Chen J, Sadick M, Raab H, Hammonds R. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell. 1995;82:355-8 pubmed
  27. Lutgens E, Tjwa M, Garcia de Frutos P, Wijnands E, Beckers L, Dahlback B, et al. Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J Pathol. 2008;216:55-63 pubmed publisher
    The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endothelial and leukocyte activation, smooth muscle cell migration and thrombosis, but its role in atherosclerosis remains uninvestigated...
  28. Kim H, Nam J, Jeon J, An J, Jung J, Bae C, et al. Serum growth arrest-specific protein 6 levels are a reliable biomarker of disease activity in systemic lupus erythematosus. J Clin Immunol. 2013;33:143-50 pubmed publisher
    Growth arrest-specific protein 6 (Gas6) has been suggested to be a biomarker of disease activity in patients with systemic lupus erthematosus (SLE). We investigated the clinical significance of this protein in Korean SLE...
  29. Munoz X, Sumoy L, Ramirez Lorca R, Villar J, de Frutos P, Sala N. Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke. Hum Mutat. 2004;23:506-12 pubmed
    The product of the growth arrest-specific gene 6 (GAS6), a ligand for the Axl, Sky, and Mer tyrosine kinase receptors, is a vitamin K-dependent protein, structurally related to anticoagulant protein S...
  30. Fiebeler A, Park J, Muller D, Lindschau C, Mengel M, Merkel S, et al. Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases. Am J Kidney Dis. 2004;43:286-95 pubmed
    Growth arrest-specific gene 6 (Gas6) and its binding partner, the receptor tyrosine kinase Axl, are important mediators in experimental nephritis...
  31. Hutterer M, Knyazev P, Abate A, Reschke M, Maier H, Stefanova N, et al. Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme. Clin Cancer Res. 2008;14:130-8 pubmed publisher
    ..However, the effect of Axl and its ligand growth arrest--specific gene 6 (Gas6) in human gliomas is still unknown...
  32. Gustafsson A, Boström A, Ljungberg B, Axelson H, Dahlback B. Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma. PLoS ONE. 2009;4:e7575 pubmed publisher
    ..Here, we have investigated the role of Axl and its ligand Gas6, the vitamin-K dependent protein product of the growth arrest-specific gene 6, in clear cell RCC (ccRCC) derived ..
  33. Hasanbasic I, Cuerquis J, Varnum B, Blostein M. Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells. Am J Physiol Heart Circ Physiol. 2004;287:H1207-13 pubmed
    b>Gas6 is a gamma-carboxylated ligand for the receptor tyrosine kinase Axl. Gas6-Axl interactions can rescue endothelial cells from apoptosis, and this study examined the intracellular signaling mechanisms responsible for this phenomenon...
  34. Stenhoff J, Dahlback B, Hafizi S. Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. Biochem Biophys Res Commun. 2004;319:871-8 pubmed
    The protein product of growth arrest specific gene 6 (Gas6), is the biological ligand for the Axl subfamily of receptor tyrosine kinases...
  35. Shankar S, O Guin K, Cammer M, McMorris F, Stitt T, Basch R, et al. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci. 2003;23:4208-18 pubmed
    ..In humans the sole known ligand for the Axl/Rse/Mer kinases is growth arrest-specific gene 6 (Gas6), which in the CNS is secreted by neurons and endothelial cells...
  36. Hsieh C, Chung R, Lee W, Lin M, Chuang L, Quertermous T, et al. Effect of Common Genetic Variants of Growth Arrest-Specific 6 Gene on Insulin Resistance, Obesity and Type 2 Diabetes in an Asian Population. PLoS ONE. 2015;10:e0135681 pubmed publisher
    Growth arrest-specific 6 (Gas6), a vitamin K-dependent protein, has been implicated in systemic inflammation, obesity, and insulin resistance (IR)...
  37. Meyer A, Zweemer A, Lauffenburger D. The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Cell Syst. 2015;1:25-36 pubmed
    ..Although the ligand-receptor (Gas6-AXL) complex structure is known, literature reports on ligand-mediated signaling have provided conflicting ..
  38. Xu D, Jiang J, He J, He C, Ma H. Characterization of porcine GAS6 cDNA gene and its expression analysis in weaned piglets. Genet Mol Res. 2015;14:17660-72 pubmed publisher
    The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain...
  39. Loeser R, Varnum B, Carlson C, Goldring M, Liu E, Sadiev S, et al. Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage. Arthritis Rheum. 1997;40:1455-65 pubmed
    ..Stimulation of axl by Gas-6 may play an important role in the control of chondrocyte growth and survival. ..
  40. Paolino M, Penninger J. The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy. Cancers (Basel). 2016;8: pubmed
    ..Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) and Protein S (Pros1), these receptors ensure the resolution of inflammation by dampening the activation of innate ..
  41. Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Pevsner Fischer M, et al. GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa. Proc Natl Acad Sci U S A. 2017;114:E337-E346 pubmed publisher
    ..Here, we studied the role of growth arrest specific 6 (GAS6), a ligand of the TYRO3-AXL-MERTK (TAM) receptor family, in regulating oral mucosal homeostasis...
  42. Chen Y, Zhao J, Jin C, Li Y, Tang M, Wang Z, et al. Testosterone delays vascular smooth muscle cell senescence and inhibits collagen synthesis via the Gas6/Axl signaling pathway. Age (Dordr). 2016;38:60 pubmed publisher
    ..vascular smooth muscle cell (VSMC) senescence and collagen synthesis via growth arrest-specific protein 6 (Gas6)/Axl- and Akt/FoxO1a-dependent pathways...
  43. Laurance S, Aghourian M, Jiva Lila Z, Lemarié C, Blostein M. Gas6-induced tissue factor expression in endothelial cells is mediated through caveolin-1-enriched microdomains. J Thromb Haemost. 2014;12:395-408 pubmed publisher
    b>Gas6 has been shown to interact with Axl in endothelial cells and to induce several signaling pathways involved in cell survival and proliferation...
  44. Decker A, Jung Y, Cackowski F, Yumoto K, Wang J, Taichman R. Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow. Mol Cancer Res. 2017;15:1644-1655 pubmed publisher
    ..marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6) expressed by osteoblasts...
  45. Lee H, Jeng Y, Chen Y, Chung L, Yuan R. Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma. Carcinogenesis. 2014;35:769-75 pubmed publisher
    ..Stimulation of HCC cell lines by Axl ligand growth arrest-specific 6 (Gas6) enhanced cell migration and invasion...
  46. Han J, Tian R, Yong B, Luo C, Tan P, Shen J, et al. Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. Biochem Biophys Res Commun. 2013;435:493-500 pubmed publisher
    Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote multiple tumorigenic processes, as well as to correlate with worse prognosis in many different tumor types...
  47. Richard A, Shim B, Kwon Y, Zhang R, Otsuka Y, Schmitt K, et al. AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Proc Natl Acad Sci U S A. 2017;114:2024-2029 pubmed publisher
    ..Consistent with this observation, only ZIKV, but not WNV or DENV, bound the AXL ligand Gas6. In comparison, when DENV and WNV were produced in insect cells, they also infected HUVECs in an AXL-dependent ..
  48. Sasaki T, Knyazev P, Cheburkin Y, Göhring W, Tisi D, Ullrich A, et al. Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains. J Biol Chem. 2002;277:44164-70 pubmed
    Receptor tyrosine kinases of the Axl family are activated by Gas6, the product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated in cell survival, adhesion, and migration...
  49. Lee E, Decker A, Cackowski F, Kana L, Yumoto K, Jung Y, et al. Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptosis During Chemotherapy in Bone Marrow. J Cell Biochem. 2016;117:2815-2824 pubmed publisher
    Prostate cancer (PCa) is known to develop resistance to chemotherapy. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers...
  50. Saccone S, Marcandalli P, Gostissa M, Schneider C, Della Valle G. Assignment of the human GAS6 gene to chromosome 13q34 by fluorescence in situ hybridization. Genomics. 1995;30:129-31 pubmed
  51. Sokol J, Biringer K, Skerenová M, Stasko J, Kubisz P, Danko J. Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. Semin Thromb Hemost. 2015;41:330-5 pubmed publisher
    ..aim of this study was to evaluate the genetic variability of selected single nucleotide polymorphisms (SNPs) within GAS6 and PEAR1 genes and explore the association between selected SNPs and risk for fetal loss in women with sticky ..
  52. Sainaghi P, Collimedaglia L, Alciato F, Molinari R, Sola D, Ranza E, et al. Growth arrest specific gene 6 protein concentration in cerebrospinal fluid correlates with relapse severity in multiple sclerosis. Mediators Inflamm. 2013;2013:406483 pubmed publisher
    Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity...
  53. Erek Toprak A, Bingöl Özakpınar Ö, Karaca Z, Cikrikcioglu M, Hursitoglu M, Uras A, et al. Association of plasma growth arrest-specific protein 6 (Gas6) concentrations with albuminuria in patients with type 2 diabetes. Ren Fail. 2014;36:737-42 pubmed publisher
    ..Recent experimental studies indicate that growth arrest-specific protein 6 (Gas6) may have a role in pathogenesis of complications associated with diabetes...
  54. Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton D, et al. Axl/Gas6/NF?B signalling in schwannoma pathological proliferation, adhesion and survival. Oncogene. 2014;33:336-46 pubmed publisher
    ..Here, we demonstrated strong overexpression and activation of Axl receptor as well as its ligand Gas6 in human schwannoma primary cells compared to normal Schwann cells...
  55. Kim H, Nam J, Jung J, Bae C, An J, Jeon J, et al. Serum growth arrest-specific protein 6 levels are elevated in adult-onset Still's disease. Clin Rheumatol. 2014;33:865-8 pubmed publisher
    ..The growth arrest-specific protein 6 in adult-onset Still's disease patients were higher than the normal controls. However, growth arrest-specific protein 6 was not correlated with disease activity. ..
  56. Jung D, Park S, Kim K, Kim C, Song S. CG200745, an HDAC inhibitor, induces anti-tumour effects in cholangiocarcinoma cell lines via miRNAs targeting the Hippo pathway. Sci Rep. 2017;7:10921 pubmed publisher
    ..This was accompanied by downregulation of YAP, TEAD4, TGF-β2, SMAD3, NOTCH3, HES5, Axl, and Gas6 and upregulation of the miRNAs miR-22-3p, miR-22-5p, miR-194-5p, miR-194-3p, miR-194-5p, miR-210-3p, and miR-509-3p...
  57. Lee C, Shieh Y, Tsai C, Hung Y, Tsai Y, Lin C. Plasma concentrations predict aortic expression of growth-arrest-specific protein 6 in patients undergoing coronary artery bypass grafting. PLoS ONE. 2013;8:e79452 pubmed publisher
    The tyrosine kinase receptor Axl is expressed in the vasculature, and growth arrest-specific protein 6 (Gas6) is its ligand...
  58. Eroglu M, Ozakpinar O, Turkgeldi L, Sahin S, Herkiloglu D, Durukan B, et al. Plasma levels of growth arrest specific protein 6 are increased in idiopathic recurrent pregnancy loss. Eur Rev Med Pharmacol Sci. 2014;18:1554-8 pubmed
    The aim of this study was to determine plasma Growth Arrest Specific Protein 6 (GAS6) protein levels in patients with unexplained recurrent pregnancy loss (RPL) and compare them to those of pregnant and to healthy non-pregnant women with ..
  59. Zweemer A, French C, Mesfin J, Gordonov S, Meyer A, Lauffenburger D. Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Mol Cancer Res. 2017;15:1656-1666 pubmed publisher
    ..In addition to its ligand growth arrest specific-6 (Gas6), activation of AXL requires the lipid moiety phosphatidylserine (PS)...
  60. Zhao R, Li Y, Dai W. Serum sex hormone and growth arrest-specific protein 6 levels in male patients with coronary heart disease. Asian J Androl. 2016;18:644-9 pubmed publisher
    ..Moreover, the tyrosine kinase receptor Axl, the ligand of which is growth arrest-specific protein 6 (GAS6), is expressed in the vasculature, and serum GAS6 levels are associated with endothelial dysfunction and ..
  61. Son B, Akishita M, Iijima K, Ogawa S, Maemura K, Yu J, et al. Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification. J Biol Chem. 2010;285:7537-44 pubmed publisher
    ..and a critical role of androgen receptor (AR)-dependent transactivation of growth arrest-specific gene 6 (Gas6), a key regulator of inorganic phosphate (P(i))-induced calcification of vascular smooth muscle cells (VSMC)...
  62. Ozakpinar O, Sahin S, Verimli N, Simsek G, Maurer A, Eroglu M, et al. Association between the growth arrest-specific 6 (Gas6) gene polymorphism c.834 + 7G>A and preeclampsia. J Matern Fetal Neonatal Med. 2016;29:1149-53 pubmed publisher
    ..The exact pathophysiology still remains unknown. Growth arrest-specific 6 (Gas6) is a member of the vitamin K-dependent protein family and it has been suggested as a novel atherothrombotic risk ..
  63. Mark M, Chen J, Hammonds R, Sadick M, Godowsk P. Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. J Biol Chem. 1996;271:9785-9 pubmed
    Rse, Ax1, and c-Mer comprise a family of cell adhesion molecule-related tyrosine kinase receptors. Human Gas6 was recently shown to act as a ligand for both human Rse (Godowski et al., 1995) and human Ax1 (Varnum et al., 1995)...
  64. Whitman S, Kohlschmidt J, Maharry K, Volinia S, Mrozek K, Nicolet D, et al. GAS6 expression identifies high-risk adult AML patients: potential implications for therapy. Leukemia. 2014;28:1252-1258 pubmed publisher
    ..We investigated the prognostic relevance of GAS6 expression, encoding the common TAM RTK ligand, in 270 adults (n=71 aged<60 years; n=199 aged ?60 years) with de ..
  65. Huang R, Antony J, Tan T, Tan D. Targeting the AXL signaling pathway in ovarian cancer. Mol Cell Oncol. 2017;4:e1263716 pubmed publisher
    ..cancer (EOC) harboring epithelial-mesenchymal transition (EMT) features has a unique signaling network downstream of the GAS6/AXL pathway. Our finding leads to a potential strategy for treating the Mes subtype of EOC by targeting AXL.
  66. Goruppi S, Yamane H, Marcandalli P, Garcia A, Clogston C, Gostissa M, et al. The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation. FEBS Lett. 1997;415:59-63 pubmed
    The product of gas6 (Gas6) is a growth factor with high level of similarity to protein S and was identified as the ligand for Axl family of tyrosine kinase receptors...
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    Growth arrest-specific 6 (gas6), a novel vitamin K-dependent protein, has been demonstrated to have a role in thrombus stabilization as gas6 null mice are resistant to lethal venous and arterial thrombosis...
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    Plasma protein growth arrest-specific 6 (GAS6) and matrix Gla protein (MGP) are crucial mediators of vascular calcification and are involved in the development of vascular complications in chronic kidney diseases...
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    ..Axl-mediated ZIKV entry requires the Axl ligand Gas6, which bridges ZIKV particles to glial cells...
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    The growth arrest-specific gene gas6 encodes a secreted protein (Gas6) which is a member of the vitamin K-dependent protein family and was identified as a ligand for the Ax1 tyrosine kinase receptor family...