Gene Symbol: GAS41
Description: YEATS domain containing 4
Alias: 4930573H17Rik, B230215M10Rik, GAS41, NUBI-1, YAF9, YEATS domain-containing protein 4, NuMA binding protein 1, glioma-amplified sequence 41, nuBI1
Species: human
Products:     GAS41

Top Publications

  1. Fischer U, Heckel D, Michel A, Janka M, Hulsebos T, Meese E. Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. Hum Mol Genet. 1997;6:1817-22 pubmed
    ..In this study, we report cloning and sequencing of a cDNA termed glioma-amplified sequence (GAS41) which was identified recently in a glioblastoma cell line by microdissection-mediated cDNA capture...
  2. Munnia A, Schutz N, Romeike B, Maldener E, Glass B, Maas R, et al. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Oncogene. 2001;20:4853-63 pubmed
    The glioma amplified sequence 41 (GAS41) was previously isolated by microdissection mediated cDNA capture from the glioblastoma multiforme cell line TX3868 and shown to be frequently amplified in human gliomas...
  3. Debernardi S, Bassini A, Jones L, Chaplin T, Linder B, de Bruijn D, et al. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Blood. 2002;99:275-81 pubmed
    ..The leucine zipper interacted with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma...
  4. Lauffart B, Howell S, Tasch J, Cowell J, Still I. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. Biochem J. 2002;363:195-200 pubmed
    ..colonic and hepatic tumour overexpressed (ch-TOG) protein, and the oncogenic transcription factor glioma amplified sequence 41/NuMA binding protein 1 (GAS41/NuBI1; where NuMA stands for nuclear mitotic apparatus protein 1)...
  5. Harborth J, Weber K, Osborn M. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. J Biol Chem. 2000;275:31979-85 pubmed
    ..It was identical to GAS41, a sequence amplified in human gliomas...
  6. Zimmermann K, Ahrens K, Matthes S, Buerstedde J, Strätling W, Phi van L. Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability. J Biol Chem. 2002;277:18626-31 pubmed
    ..To investigate its functional role in vivo, we attempted to knock out the GAS41 gene by targeted disruption in the chicken pre-lymphoid cell line DT40...
  7. Doyon Y, Selleck W, Lane W, Tan S, Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004;24:1884-96 pubmed
    ..In conclusion, the NuA4 HAT complex is highly conserved in eukaryotes, in which it plays primary roles in transcription, cellular response to DNA damage, and cell cycle control. ..
  8. Turner S, Bailey K, Fridley B, Chapman A, Schwartz G, Chai H, et al. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. Hypertension. 2008;52:359-65 pubmed publisher
    ..These results support the use of genome-wide association analyses to identify novel genes influencing antihypertensive drug responses. ..
  9. Park J, Roeder R. GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Mol Cell Biol. 2006;26:4006-16 pubmed
    b>GAS41 is a common subunit of the TIP60 and SRCAP complexes and is essential for cell growth and viability. Here, we report that GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation...

More Information


  1. Ding X, Fan C, Zhou J, Zhong Y, Liu R, Ren K, et al. GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic Acids Res. 2006;34:2570-8 pubmed
    ..In this study, we reported the identification of GAS41 as an interaction partner of AP-2beta...
  2. Cai Y, Jin J, Florens L, Swanson S, Kusch T, Li B, et al. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem. 2005;280:13665-70 pubmed
    ..Taken together, our findings identify the YL1 protein as a new subunit of the TRRAP/TIP60 HAT complex, and they suggest that YL1 plays multiple roles in chromatin modification and remodeling in cells. ..
  3. Hsu C, Zhao D, Shi J, Peng D, Guan H, Li Y, et al. Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell Discov. 2018;4:28 pubmed publisher
    ..Z in the chromatin. Here we show that Glioma Amplified Sequence 41 (Gas41), a shared subunit of the two H2A...
  4. Creytens D, van Gorp J, Speel E, Ferdinande L. Characterization of the 12q amplicons in lipomatous soft tissue tumors by multiplex ligation-dependent probe amplification-based copy number analysis. Anticancer Res. 2015;35:1835-42 pubmed
    ..In addition, we identified additional genes exclusively amplified in DDLPS, which may play a role in liposarcomagenesis, particularly in the de-differentiation process. ..
  5. Huang G, Jiang H, Lin Y, Wu Y, Cai W, Shi B, et al. lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling. Cell Death Dis. 2018;9:487 pubmed publisher
    ..In conclusions, our study showed that lncAKHE may promote tumor progression in HCC and serve as a novel target for HCC treatment. ..
  6. Bieluszewski T, Galganski L, Sura W, Bieluszewska A, Abram M, Ludwikow A, et al. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. BMC Plant Biol. 2015;15:75 pubmed publisher
    ..of NuA4 and SWR1-C subunits ARP4 and SWC4 and interacts physically with AtYAF9A and AtYAF9B, homologues of the YAF9 subunit...
  7. Gandhi S, Bag I, Sengupta S, Pal Bhadra M, Bhadra U. Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway. FEBS J. 2015;282:153-73 pubmed publisher
    Glioma amplified sequence41 (Gas41) is a highly conserved putative transcription factor that is frequently abundant in human gliomas. Gas41 shows oncogenic activity by promoting cell growth and viability...
  8. Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, et al. Identification of commonly altered genes between in major depressive disorder and a mouse model of depression. Sci Rep. 2017;7:3044 pubmed publisher
    ..Taken together, our findings suggest that HIST1H2AL may be a biological marker of MDD. ..
  9. Wang A, Schulze J, Skordalakes E, Gin J, Berger J, Rine J, et al. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A. 2009;106:21573-8 pubmed publisher
    ..The Saccharomyces cerevisiae protein Yaf9 is a subunit of both the essential histone acetyltransferase complex NuA4 and the ATP-dependent chromatin ..
  10. Lee J, Lu T, Changou C, Liang C, Huang H, Lauria A, et al. Genomewide copy number analysis of Müllerian adenosarcoma identified chromosomal instability in the aggressive subgroup. Mod Pathol. 2016;29:1070-82 pubmed publisher
    ..To our knowledge, this is the first time that evidence of chromothripsis has been demonstrated in paraffin-embedded clinical tissues and in adenosarcomas. ..
  11. Shahin M, Johnson J. Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response. Curr Opin Pharmacol. 2016;27:31-7 pubmed publisher
    ..Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response. ..
  12. Wang Y, Jin J, Chung M, Feng L, Sun H, Hao Q. Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Proc Natl Acad Sci U S A. 2018;115:2365-2370 pubmed publisher
    ..Following our previous study of SIRT5 as an eraser of succinyl-lysine (Ksuc), here we identified the GAS41 YEATS domain as a reader of Ksuc on histones...
  13. Johnsson M, Henriksen R, Höglund A, Fogelholm J, Jensen P, Wright D. Genetical genomics of growth in a chicken model. BMC Genomics. 2018;19:72 pubmed publisher
    ..These findings not only serve to identify several strong candidates affecting growth, but also show how sex-specificity and local gene-regulation affect growth regulation in the chicken. ..
  14. Zhao D, Li Y, Xiong X, Chen Z, Li H. YEATS Domain-A Histone Acylation Reader in Health and Disease. J Mol Biol. 2017;429:1994-2002 pubmed publisher
    ..The Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain is an emerging reader module that selectively recognizes histone lysine ..
  15. Cai Y, Jin J, Tomomori Sato C, Sato S, Sorokina I, Parmely T, et al. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem. 2003;278:42733-6 pubmed
    ..Taken together, our findings shed new light on the structure and function of the mammalian TRRAP/TIP60 histone acetyltransferase complex. ..
  16. Duarte J, Turner S, Tran B, Chapman A, Bailey K, Gong Y, et al. Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression. Pharmacogenomics J. 2013;13:257-63 pubmed publisher
    ..Our data confirm previous genome-wide findings at 12q15 and suggest differential YEATS4 expression could underpin rs7297610-associated HCTZ response variability, which may have future implications for guiding thiazide treatment. ..
  17. Pikor L, Lockwood W, Thu K, Vucic E, Chari R, Gazdar A, et al. YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer Res. 2013;73:7301-12 pubmed publisher
    ..Taken together, our findings reveal YEATS4 as a candidate oncogene amplified in NSCLC, and a novel mechanism contributing to NSCLC pathogenesis. ..
  18. Ji S, Zhang Y, Yang B. YEATS Domain Containing 4 Promotes Gastric Cancer Cell Proliferation and Mediates Tumor Progression via Activating the Wnt/β-Catenin Signaling Pathway. Oncol Res. 2017;25:1633-1641 pubmed publisher
  19. Gracia E, Fischer U, Elkahloun A, Trent J, Meese E, Meltzer P. Isolation of genes amplified in human cancers by microdissection mediated cDNA capture. Hum Mol Genet. 1996;5:595-600 pubmed
  20. Pal D, Mukhopadhyay D, Ramaiah M, Sarma P, Bhadra U, Bhadra M. Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells. PLoS ONE. 2016;11:e0159092 pubmed publisher
    b>Glioma amplified sequence 41(GAS41) is a potent transcription factor that play a crucial role in cell proliferation and survival...
  21. Fu Q, Cheng J, Zhang J, Zhang Y, Chen X, Xie J, et al. Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy. Oncol Rep. 2016;36:3682-3690 pubmed publisher
    ..In conclusion, miR-218 sensitized HCT-116/L-OHP cells to L-OHP-induced cell apoptosis via inhibition of cytoprotective autophagy by targeting YEATS4 expression. ..
  22. Jahan S, Sun J, He S, Davie J. Transcription-dependent association of HDAC2 with active chromatin. J Cell Physiol. 2018;233:1650-1657 pubmed publisher
    ..HDAC2S394ph was present primarly at the upstream promoter region of the transcribed CA2 and GAS41 genes, while total HDAC2 was also found within the coding region of the CA2 gene...
  23. Doyon Y, Cote J. The highly conserved and multifunctional NuA4 HAT complex. Curr Opin Genet Dev. 2004;14:147-54 pubmed
    ..Recent studies presented here have established its remarkable structural conservation from yeast to human cells and contributed to the understanding of its diverse functions. ..
  24. Bönisch C, Schneider K, Pünzeler S, Wiedemann S, Bielmeier C, Bocola M, et al. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res. 2012;40:5951-64 pubmed
    ..Our findings enrich the list of known human variants by an unusual protein belonging to the H2A.Z family that leads to the least stable nucleosome known to date. ..
  25. Jixiang C, Shengchun D, Jianguo Q, Zhengfa M, Xin F, Xuqing W, et al. YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling. Oncotarget. 2017;8:25200-25210 pubmed publisher
  26. Heisel S, Habel N, Schuetz N, Ruggieri A, Meese E. The YEATS family member GAS41 interacts with the general transcription factor TFIIF. BMC Mol Biol. 2010;11:53 pubmed publisher
    ..The glioma amplified sequence 41 (GAS41) has been associated with TFIIF via its YEATS domain...
  27. Klein B, Ahmad S, Vann K, Andrews F, Mayo Z, Bourriquen G, et al. Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Res. 2017;: pubmed publisher
    b>Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac...
  28. Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot Leccia N, Coindre J, et al. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Int J Cancer. 2008;122:2233-41 pubmed publisher
    ..RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14.1) belonged to a distinct amplicon than MDM2 (12q15)...
  29. Greliche N, Germain M, Lambert J, Cohen W, Bertrand M, Dupuis A, et al. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. BMC Med Genet. 2013;14:36 pubmed publisher
    ..This study, the first genome-wide SNP interaction analysis conducted so far on VT risk, suggests that common SNPs are unlikely exerting strong interactive effects on the risk of disease. ..
  30. Park J, Smith R, Shieh S, Roeder R. The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability. J Biol Chem. 2011;286:10911-7 pubmed publisher
    ..We demonstrate here that the newly identified complex GAS41-PP2C?, and not PP2C? alone, is specifically required for dephosphorylation of serine 366 on p53...
  31. Lauffart B, Gangisetty O, Still I. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. Genomics. 2003;81:192-201 pubmed
    ..Significantly, we demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex...
  32. Kim Y, Park M, Eum K, Kim J, Lee J, Bae T, et al. Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer. Oncotarget. 2015;6:31030-8 pubmed publisher
    ..Thus, we suggest a novel approach to reverse chemoresistance of ovarian cancer by suppressing TFEB1 and YEATS4. ..
  33. Piccinni E, Chelstowska A, Hanus J, Widlak P, Loreti S, Tata A, et al. Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours. Acta Biochim Pol. 2011;58:529-34 pubmed
    In order to understand better the role of the human Tip60 complex component Gas41, we analysed its expression levels in brain tumours and searched for possible interactors...
  34. Schmitt J, Fischer U, Heisel S, Strickfaden H, Backes C, Ruggieri A, et al. GAS41 amplification results in overexpression of a new spindle pole protein. Genes Chromosomes Cancer. 2012;51:868-80 pubmed publisher
    ..Previously, we identified a frequently amplified gene in glioma termed glioma-amplified sequence 41 (GAS41)...