Gene Symbol: GAREM1
Description: GRB2 associated regulator of MAPK1 subtype 1
Alias: C18orf11, FAM59A, GAREM, Gm944, GRB2-associated and regulator of MAPK protein 1, GRB2 associated regulator of MAPK1 1, GRB2 associated, regulator of MAPK1, GRB2-associated and regulator of MAPK1, Grb2-associated and regulator of Erk/MAPK, family with sequence similarity 59, member A, protein FAM59A
Tashiro K, Tsunematsu T, Okubo H, Ohta T, Sano E, Yamauchi E, et al
. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. J Biol Chem. 2009;284:20206-14 pubmed publisher
..Here, we focus on a novel protein, GAREM (Grb2-associated and regulator of Erk/MAPK) as a downstream molecule of the EGF receptor...
Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al
. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
Nishino T, Matsunaga R, Konishi H. Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization. Biochem Biophys Res Commun. 2015;464:616-21 pubmed publisher
b>GAREM1 (Grb2-associated regulator of Erk/MAPK1) is an adaptor protein that is involved in the epidermal growth factor (EGF) pathway...
Taniguchi T, Tanaka S, Ishii A, Watanabe M, Fujitani N, Sugeo A, et al
. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. J Biol Chem. 2013;288:29934-42 pubmed publisher
..Two GAREM homologues are encoded by the human genome. Therefore, previously identified GAREM is named GAREM1. Here we characterized a new subtype of GAREM, GAREM2, that is specifically expressed in the mouse, rat, and human ..