gammaN crystallin

Summary

Gene Symbol: gammaN crystallin
Description: crystallin gamma N
Alias: gamma-crystallin N, gamma-N-crystallin, gammaN-crystallin
Species: human
Products:     gammaN crystallin

Top Publications

  1. Graw J. Genetics of crystallins: cataract and beyond. Exp Eye Res. 2009;88:173-89 pubmed publisher
    ..Mutations in the human CRYM gene lead to non-syndromic deafness, and mutations in the Cryz gene of guinea pigs cause cataracts...
  2. Hartwich H, Rosengauer E, Ruttiger L, Wilms V, Waterholter S, Nothwang H. Functional Role of ?-Crystallin N in the Auditory Hindbrain. PLoS ONE. 2016;11:e0161140 pubmed publisher
    ..Crygn is hence required for postmigratory survival and proper function of auditory hindbrain neurons. These results ascertain for the first time an essential extralenticular role for ?-crystallins in vivo. ..
  3. Wistow G, Wyatt K, David L, Gao C, Bateman O, Bernstein S, et al. gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. FEBS J. 2005;272:2276-91 pubmed
    ..Although well conserved throughout vertebrate evolution, gammaN in primates has apparently undergone major changes and possible loss of functional expression. ..
  4. Leparc G, Mitra R. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Nucleic Acids Res. 2007;35:3192-202 pubmed
    ..Overall, PASE was able to uncover 59 novel alternative cassette exons in C. elegans and humans through a genome-wide ab initio prediction method that enriches for exons involved in signaling. ..
  5. Breton C, Siegmund K, Joubert B, Wang X, Qui W, Carey V, et al. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. PLoS ONE. 2014;9:e99716 pubmed publisher
    ..These data suggest that prenatal exposure to tobacco smoke is associated with reproducible epigenetic changes that persist well into childhood. However, the biological significance of these altered loci remains unknown. ..