gamma-tubulin

Summary

Gene Symbol: gamma-tubulin
Description: tubulin gamma 1
Alias: CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma-1 chain, gamma-tubulin complex component 1, tubulin, gamma polypeptide
Species: human
Products:     gamma-tubulin

Top Publications

  1. Aldaz H, Rice L, Stearns T, Agard D. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. Nature. 2005;435:523-7 pubmed
    ..The lateral array of gamma-tubulins we observe in the crystal reveals a unique functional property of a monomeric tubulin. ..
  2. Zheng Y, Jung M, Oakley B. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Cell. 1991;65:817-23 pubmed
  3. Tassin A, Celati C, Moudjou M, Bornens M. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. J Cell Biol. 1998;141:689-701 pubmed
    ..Finally, affinity-purified antibodies against Spc98p inhibit microtubule nucleation on isolated centrosomes, as well as in microinjected cells, suggesting that this novel protein is indeed required for the nucleation reaction. ..
  4. Chen Z, Indjeian V, McManus M, Wang L, Dynlacht B. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002;3:339-50 pubmed
    ..Our data suggest that CP110 is a physiological centrosomal CDK target that promotes centrosome duplication, and its deregulation may contribute to genomic instability. ..
  5. Katsetos C, Dráberová E, Smejkalová B, Reddy G, Bertrand L, de Chadarevian J, et al. Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. Neurochem Res. 2007;32:1387-98 pubmed
    ..We suggest that aberrant expression and interactions of betaIII-tubulin and gamma-tubulin may be linked to malignant changes in glial cells. ..
  6. Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, et al. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. J Cell Sci. 2009;122:2240-51 pubmed publisher
  7. Feng Y, Olson E, Stukenberg P, Flanagan L, Kirschner M, Walsh C. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000;28:665-79 pubmed
    ..Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC. ..
  8. Starita L, Machida Y, Sankaran S, Elias J, Griffin K, Schlegel B, et al. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol. 2004;24:8457-66 pubmed
    ..The results of this study identify a ubiquitination target and suggest a biological impact important in the etiology of breast cancer. ..
  9. Kim A, Puram S, Bilimoria P, Ikeuchi Y, Keough S, Wong M, et al. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009;136:322-36 pubmed publisher
    ..The identification of a centrosomal Cdc20-APC ubiquitin signaling pathway holds important implications for diverse biological processes, including neuronal connectivity and plasticity. ..

More Information

Publications104 found, 100 shown here

  1. Alvarado Kristensson M, Rodriguez M, Silio V, Valpuesta J, Carrera A. SADB phosphorylation of gamma-tubulin regulates centrosome duplication. Nat Cell Biol. 2009;11:1081-92 pubmed publisher
    ..We propose that SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin. ..
  2. Fava F, Raynaud Messina B, Leung Tack J, Mazzolini L, Li M, Guillemot J, et al. Human 76p: A new member of the gamma-tubulin-associated protein family. J Cell Biol. 1999;147:857-68 pubmed
    ..Hence, human gamma-tubulin appears associated with at least three evolutionary related centrosomal proteins, raising new questions about their functions at the molecular level. ..
  3. Fong K, Choi Y, Rattner J, Qi R. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. Mol Biol Cell. 2008;19:115-25 pubmed
    ..Our findings suggest that centrosome malfunction due to the CDK5RAP2 mutations may underlie autosomal recessive primary microcephaly. ..
  4. Niu Y, Liu T, Tse G, Sun B, Niu R, Li H, et al. Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast. Cancer Sci. 2009;100:580-7 pubmed publisher
    ..Furthermore, determination of alpha, gamma-tubulins using combined qPCR with ISH may be useful in assisting the diagnosis of premalignant lesions of the breast. ..
  5. Haren L, Stearns T, Lüders J. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS ONE. 2009;4:e5976 pubmed publisher
    ..Our results support a model in which Plk1-dependent recruitment of gamma-tubulin to mitotic centrosomes is regulated upstream of GCP-WD, involves multiple PCM proteins and therefore potentially multiple Plk1 substrates. ..
  6. Maounis N, Dráberová E, Mahera E, Chorti M, Caracciolo V, Sulimenko T, et al. Overexpression of ?-tubulin in non-small cell lung cancer. Histol Histopathol. 2012;27:1183-94 pubmed publisher
    ..In both tumor cell lines increase in TUBG1 and TUBG2 transcripts was detected by RT-qPCR. Our results reveal for the first time an increased expression of ?-tubulin in lung cancer. ..
  7. Romaniello R, Arrigoni F, Fry A, Bassi M, Rees M, Borgatti R, et al. Tubulin genes and malformations of cortical development. Eur J Med Genet. 2018;61:744-754 pubmed publisher
    ..In addition, the most typical neuroimaging patterns of malformations of cortical development associated with tubulin gene mutations detected on the basis of our own experience are described. ..
  8. Wang Z, Chen P, Tao N, Zhang H, Li R, Zhan X, et al. Anticancer Activity of Polysaccharides Produced from Glycerol and Crude Glycerol by an Endophytic Fungus Chaetomium globosum CGMCC 6882 on Human Lung Cancer A549 Cells. Biomolecules. 2018;8: pubmed publisher
    ..This research provided an innovative approach to using a byproduct of biodiesel production (crude glycerol) to produce polysaccharides of potential medicinal benefit. ..
  9. Srivastava D, Chakrabarti O. Mahogunin-mediated ?-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. Cell Death Dis. 2014;5:e1064 pubmed publisher
    ..MGRN1-mediated ?-tubulin modification, and hence its stability, may highlight a key event in the LR patterning during embryogenesis. ..
  10. Rozanska E, Czarnocka W, Baranowski Ł, Mielecki J, de Almeida Engler J, Sobczak M. Expression of both Arabidopsis γ-tubulin genes is essential for development of a functional syncytium induced by Heterodera schachtii. Plant Cell Rep. 2018;37:1279-1292 pubmed publisher
    ..Our results indicate that the expression of both TUBG1 and TUBG2 genes, although generally down-regulated in mature syncytia, is essential for successful root infection, development of functional syncytium and nematode maturation. ..
  11. Hashizume C, Moyori A, Kobayashi A, Yamakoshi N, Endo A, Wong R. Nucleoporin Nup62 maintains centrosome homeostasis. Cell Cycle. 2013;12:3804-16 pubmed publisher
    ..Our results also point to a potential role of Nup62 in targeting gamma-tubulin and SAS-6 to the centrioles. ..
  12. Olmsted Z, Colliver A, Riehlman T, Paluh J. Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells. Nat Commun. 2014;5:5339 pubmed publisher
  13. Di Donato N, Timms A, Aldinger K, Mirzaa G, Bennett J, Collins S, et al. Analysis of 17 genes detects mutations in 81% of 811 patients with lissencephaly. Genet Med. 2018;20:1354-1364 pubmed publisher
    ..The brain-imaging pattern correlates with mutations in single lissencephaly-associated genes, as well as in biological pathways. We propose the first LIS classification system based on the underlying molecular mechanisms. ..
  14. Suri C, Hendrickson T, Joshi H, Naik P. Molecular insight into γ-γ tubulin lateral interactions within the γ-tubulin ring complex (γ-TuRC). J Comput Aided Mol Des. 2014;28:961-72 pubmed publisher
    ..Consistent with our model, γ-tubulin mutants that fall into our identified hotspot do not support yeast growth. ..
  15. Brock S, Stouffs K, Scalais E, D Hooghe M, Keymolen K, Guerrini R, et al. Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1. Eur J Hum Genet. 2018;26:1132-1142 pubmed publisher
    ..k.a. PAFAH1B1). This difference may, at least in part, be explained by gamma-tubulin's physiological function in microtubule nucleation, which differs from that of alpha and beta-tubulin. ..
  16. Izumi N, Fumoto K, Izumi S, Kikuchi A. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. J Biol Chem. 2008;283:12981-91 pubmed publisher
    ..Our findings suggest that GSK-3beta regulates the localization of gammaTuRC, including GCP5, to the spindle poles, thereby controlling the formation of proper mitotic spindles. ..
  17. Dráberová E, Sulimenko V, Vinopal S, Sulimenko T, Sladkova V, D Agostino L, et al. Differential expression of human ?-tubulin isotypes during neuronal development and oxidative stress points to a ?-tubulin-2 prosurvival function. FASEB J. 2017;31:1828-1846 pubmed publisher
    ..D'Agostino, L., Sobol, M., Hozák, P., K?en, L., Katsetos, C. D., Dráber, P. Differential expression of human ?-tubulin isotypes during neuronal development and oxidative stress points to ?-tubulin-2 prosurvival function. ..
  18. Liu Y, Gong R, Liu X, Zhang P, Zhang Q, Cai Y, et al. Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090. Microb Cell Fact. 2018;17:131 pubmed publisher
    ..Finally, we verified that TubG acts as a Nudix hydrolase, preferring Co2+ for the maintenance of maximal activity, and is responsible ..
  19. Brown M, Turner C. Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol. 2002;34:855-63 pubmed
    ..Interestingly, expression of tandem LIM2-3 inhibited cell adhesion and spreading while LIM3-4 stimulated a well-spread polarized phenotype. These data offer further support for a critical role for paxillin in cell adhesion and motility. ..
  20. Zeiger A, Layton B. Molecular modeling of the axial and circumferential elastic moduli of tubulin. Biophys J. 2008;95:3606-18 pubmed publisher
    ..Additionally, an intergenomic approach to investigating the mechanical properties of proteins may provide a way to elucidate the evolutionary mechanical constraints imposed by nature upon individual subcellular components. ..
  21. Tsai H, Tsai C, Lieu A, Chai C, Kwan A, Howng S, et al. Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival. Neurol Res. 2014;36:746-51 pubmed publisher
    ..These findings support the idea that these factors may potentially be important prognostic indicators for patients with astrocytomas. ..
  22. Fumoto K, Kadono M, Izumi N, Kikuchi A. Axin localizes to the centrosome and is involved in microtubule nucleation. EMBO Rep. 2009;10:606-13 pubmed publisher
    ..These results suggest that Axin, but not Axin2, is involved in microtubule nucleation by forming a complex with gamma-tubulin at the centrosome. ..
  23. Jolly C, Mitar I, Sattentau Q. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol. 2007;81:5547-60 pubmed
    ..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS. ..
  24. Wang X, Yang Y, Duan Q, Jiang N, Huang Y, Darzynkiewicz Z, et al. sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell. 2008;14:331-41 pubmed publisher
    ..Our studies strongly suggest that sSgo1 plays an essential role in protecting centriole cohesion, which is partly regulated by Plk1. ..
  25. Thirunavukarasou A, Govindarajalu G, Singh P, Bandi V, Muthu K, Baluchamy S. Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination. Mol Cell Biochem. 2015;401:219-28 pubmed publisher
    ..Overall, our observation has identified γ-tubulin as a novel target for E3 ubiquitin ligase CUL4 complex, and might lead to the establishment of a unique mechanism for controlling centrosome stability. ..
  26. He M, Zhang L, Wang X, Huo L, Sun L, Feng C, et al. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. PLoS ONE. 2013;8:e67186 pubmed publisher
    ..Our findings suggest that Tat may regulate diverse cellular activities through binding to different proteins and that the acetylation of distinct lysine residues in Tat may modulate its interaction with various partners. ..
  27. Hehnly H, Doxsey S. Rab11 endosomes contribute to mitotic spindle organization and orientation. Dev Cell. 2014;28:497-507 pubmed publisher
    ..We propose that Rab11 and its associated endosomes cocontribute to these processes through retrograde transport to poles by dynein...
  28. Schmidt M, Chen B, Randazzo L, Bogler O. SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci. 2003;116:2845-55 pubmed
  29. Kapeller R, Toker A, Cantley L, Carpenter C. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. J Biol Chem. 1995;270:25985-91 pubmed
    ..These data suggest that phosphoinositide 3-kinase may be involved in regulating microtubule responses to insulin and platelet-derived growth factor. ..
  30. Wise D, Krahe R, Oakley B. The gamma-tubulin gene family in humans. Genomics. 2000;67:164-70 pubmed
    ..In addition, any pharmacological agents that target one human gamma-tubulin are likely to target both. ..
  31. Hsu L, Doan T, White R. Identification of a gamma-tubulin-binding domain in BRCA1. Cancer Res. 2001;61:7713-8 pubmed
    ..Thus, attenuating the interaction between BRCA1 and gamma-tubulin, and their association with mitotic centrosomes, may induce an increase of aneuploid cell population and contribute to tumorigenesis. ..
  32. Jung Y, Chun H, Yoon M, Park B. Elevated estrogen receptor-α in VHL-deficient condition induces microtubule organizing center amplification via disruption of BRCA1/Rad51 interaction. Neoplasia. 2014;16:1070-81 pubmed publisher
    ..Our results suggest that pVHL-mediated ER-α suppression is important for regulation of MTOC as well as drug resistance. ..
  33. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, et al. Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J Cell Biol. 2004;164:557-66 pubmed
    ..Together, it is concluded that Nudel is critical for dynein motor activity in membrane transport and possibly other cellular activities through interactions with both Lis1 and dynein heavy chain. ..
  34. Dönmez Ö, Mogol B, Gökmen V. Syneresis and rheological behaviors of set yogurt containing green tea and green coffee powders. J Dairy Sci. 2017;100:901-907 pubmed publisher
    ..In conclusion, GTP and GCP behaved differently in acidified gel networks of set yogurt, modifying its rheological behavior, as they have different profiles and concentrations of polyphenols. ..
  35. Vadhvani M, Schwedhelm Domeyer N, Mukherjee C, Stegmuller J. The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration. PLoS ONE. 2013;8:e57530 pubmed publisher
    ..Finally, we ascribe a role for FBXO31 in dendrite growth and neuronal migration in the developing cerebellar cortex. Taken together, we uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator of neuronal development. ..
  36. Lin C, Cheng T, Hsu C, Wu C, Chang L, Shen Z, et al. Characterization and functional aspects of human ninein isoforms that regulated by centrosomal targeting signals and evidence for docking sites to direct gamma-tubulin. Cell Cycle. 2006;5:2517-27 pubmed
  37. Lui C, Ashton C, Sharma M, Brocardo M, Henderson B. APC functions at the centrosome to stimulate microtubule growth. Int J Biochem Cell Biol. 2016;70:39-47 pubmed publisher
    ..While binding to γ-tubulin may help target APC to the site of MT nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize MT growth. ..
  38. Choi Y, Liu P, Sze S, Dai C, Qi R. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. J Cell Biol. 2010;191:1089-95 pubmed publisher
    ..Collectively, these results suggest that the ?-TuNA found in CDK5RAP2 has regulatory functions in ?-TuRC-mediated microtubule nucleation. ..
  39. Hubert T, Perdu S, Vandekerckhove J, Gettemans J. ?-Tubulin localizes at actin-based membrane protrusions and inhibits formation of stress-fibers. Biochem Biophys Res Commun. 2011;408:248-52 pubmed publisher
    ..The data presented here indicate that ?-tubulin has a profound relationship with actin filament dynamics. ..
  40. Andrade V, Guerra M, Jardim C, Melo F, Silva W, Ortega J, et al. Nucleoplasmic calcium regulates cell proliferation through legumain. J Hepatol. 2011;55:626-635 pubmed publisher
    ..Increased expression of LGMN may be involved in liver carcinogenesis. ..
  41. Shi C, Sang Y, Sun G, Li T, Gong Z, Wang X. Characterization and bioactivities of a novel polysaccharide obtained from Gracilariopsis lemaneiformis. An Acad Bras Cienc. 2017;89:175-189 pubmed publisher
    ..It may represent a potential material for health food and clinical medicines. ..
  42. Nishimura T, Takahashi M, Kim H, Mukai H, Ono Y. Centrosome-targeting region of CG-NAP causes centrosome amplification by recruiting cyclin E-cdk2 complex. Genes Cells. 2005;10:75-86 pubmed
  43. Matsuzawa A, Kanno S, Nakayama M, Mochiduki H, Wei L, Shimaoka T, et al. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Mol Cell. 2014;53:101-14 pubmed publisher
    ..BRCA1 variant I42V also abrogated the binding of BRCA1 to OLA1. These findings suggest that OLA1 plays an important role in centrosome regulation together with BRCA1. ..
  44. Manning J, Shalini S, Risk J, Day C, Kumar S. A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome. PLoS ONE. 2010;5:e9618 pubmed publisher
    ..Hence, this study defines the binding site on NEDD1 that is required for its interaction with gamma-tubulin, and shows that this interaction is required for the correct localization of gamma-tubulin. ..
  45. Kim J, Shinde D, Reijnders M, Hauser N, Belmonte R, Wilson G, et al. De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. Am J Hum Genet. 2016;99:711-719 pubmed publisher
    ..Our data highlight SON as a master regulator governing neurodevelopment and demonstrate the importance of SON-mediated RNA splicing in human development. ..
  46. Hořejší B, Vinopal S, Sladkova V, Dráberová E, Sulimenko V, Sulimenko T, et al. Nuclear ?-tubulin associates with nucleoli and interacts with tumor suppressor protein C53. J Cell Physiol. 2012;227:367-82 pubmed publisher
    ..The combined results indicate that aside from its known role in microtubule nucleation, ?-tubulin may also have nuclear-specific function(s). ..
  47. Salas P. Insoluble gamma-tubulin-containing structures are anchored to the apical network of intermediate filaments in polarized CACO-2 epithelial cells. J Cell Biol. 1999;146:645-58 pubmed
    ..Drastic changes in the extraction protocol did not affect coimmunoprecipitation. These results from three independent techniques, indicate that insoluble gamma-tubulin-containing structures are attached to apical intermediate filaments. ..
  48. Fant X, Gnadt N, Haren L, Merdes A. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. J Cell Sci. 2009;122:1134-44 pubmed publisher
    ..We propose that HCA66 is a novel regulator of gamma-tubulin function that plays a role in stabilizing components of the gamma-tubulin small complex, which is in turn essential for assembling the larger gamma-tubulin ring complex. ..
  49. Hsu L, White R. BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A. 1998;95:12983-8 pubmed
    ..Furthermore, gamma-tubulin associates preferentially with a hypophosphorylated form of BRCA1. ..
  50. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun. 2001;281:706-13 pubmed
    ..These results strongly suggest that Dorfin is a new member of RING-finger type ubiquitin ligase. Dorfin is localized in the centrosome and probably functions in the microtubule organizing centers. ..
  51. Liu L, Tommasi S, Lee D, Dammann R, Pfeifer G. Control of microtubule stability by the RASSF1A tumor suppressor. Oncogene. 2003;22:8125-36 pubmed
    ..In addition, knowledge of the microtubule-targeting function of RASSF1 may aid in the development of new anticancer drugs. ..
  52. Chang F, Re F, Sebastian S, Sazer S, Luban J. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Mol Biol Cell. 2004;15:1793-801 pubmed
    ..These defects in cell division and centrosomes might account for some of the pathological effects associated with HIV-1 infection. ..
  53. de Mareuil J, Carre M, Barbier P, Campbell G, Lancelot S, Opi S, et al. HIV-1 Tat protein enhances microtubule polymerization. Retrovirology. 2005;2:5 pubmed
    ..These results show that Tat directly acts on microtubule polymerization and provide insights into the mechanism of T cell apoptosis mediated by extra-cellular Tat. ..
  54. Zyss D, Montcourrier P, Vidal B, Anguille C, Merezegue F, Sahuquet A, et al. The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression. Cancer Res. 2005;65:10872-80 pubmed
    ..Its expression is strictly controlled in a spatiotemporal manner, and centrosomal Syk levels need to decline to allow customary progression of mitosis. ..
  55. Pan H, Chou H, Liu S, Peng S, Liu C, Hsu H. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. Cell Cycle. 2006;5:2676-87 pubmed
    ..L2DTL overexpression is associated with enhanced metastatic potential of HCC, and contributes synergistically with p53 mutation, which leads to the loss of p53-governed checkpoints, toward advanced HCC with poor prognosis. ..
  56. Guillet V, Knibiehler M, Gregory Pauron L, Remy M, Chemin C, Raynaud Messina B, et al. Crystal structure of ?-tubulin complex protein GCP4 provides insight into microtubule nucleation. Nat Struct Mol Biol. 2011;18:915-9 pubmed publisher
    ..The human GCP4 structure is the prototype for all GCPs, as it can be precisely positioned within the ?TuSC envelope, revealing the nature of protein-protein interactions and conformational changes regulating nucleation activity. ..
  57. Castelli M, Piobbico D, Bartoli D, Pieroni S, Brunacci C, Bellet M, et al. Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system. Cell Cycle. 2014;13:293-302 pubmed publisher
  58. Feng Y, Hodge D, Palmieri G, Chase D, Longo D, Ferris D. Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex. Biochem J. 1999;339 ( Pt 2):435-42 pubmed
    ..The specific interaction between Plk and tubulins might provide a molecular basis for the physiological functions of Plk in regulating the cell cycle, particularly in establishing the normal bipolar spindle. ..
  59. Wigley W, Fabunmi R, Lee M, Marino C, Muallem S, DeMartino G, et al. Dynamic association of proteasomal machinery with the centrosome. J Cell Biol. 1999;145:481-90 pubmed
    ..Thus, the centrosome may act as a scaffold, which concentrates and recruits the systems which act as censors and modulators of the balance between folding, aggregation, and degradation. ..
  60. Hung L, Tang C, Tang T. Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. Mol Cell Biol. 2000;20:7813-25 pubmed
    ..The formation of microtubule asters was significantly inhibited by anti-CPAP antibody. Together, these observations indicate that CPAP may play an important role in cell division and centrosome function. ..
  61. McDermott K, Zhang J, Holst C, Kozakiewicz B, Singla V, Tlsty T. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 2006;4:e51 pubmed
    ..Gain or loss of genomic material (aneuploidy) may provide the necessary proproliferation and antiapoptotic mechanisms needed for the earliest stages of tumorigenesis. ..
  62. Nakanishi A, Han X, Saito H, Taguchi K, Ohta Y, Imajoh Ohmi S, et al. Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem Biophys Res Commun. 2007;355:34-40 pubmed
    ..These results thus implicate BRCA2 in the regulation of the centrosome cycle, and provide new insight into the aneuploid nature of many breast cancers. ..
  63. Peth A, Boettcher J, Dubiel W. Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability. J Mol Biol. 2007;368:550-63 pubmed
    ..A nocodazole-induced cell-cycle arrest was partially rescued by CSN1 or EB1. These data demonstrate that the CSN-dependent protection of EB1 is important for microtubule function. ..
  64. Rice L, Montabana E, Agard D. The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly. Proc Natl Acad Sci U S A. 2008;105:5378-83 pubmed publisher
    ..These data provide new insights into the molecular origins of dynamic microtubule behavior. ..
  65. Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J. CEP70 protein interacts with ?-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. J Biol Chem. 2011;286:33401-8 pubmed publisher
    ..These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with ?-tubulin and underscore its critical role in the regulation of mitotic spindle assembly. ..
  66. Kim S, Hwang S, Lee M, Kwak H, Son K, Yang J, et al. Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity. Int J Biochem Cell Biol. 2013;45:1953-61 pubmed publisher
    ..Taken together, this study revealed that FANCA localizes to centrosomes and is required for the maintenance of centrosome integrity, possibly through its phosphorylation at T351 by Nek2. ..
  67. Ohashi T, Yamamoto T, Yamanashi Y, Ohsugi M. Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth. FEBS Lett. 2016;590:1053-63 pubmed publisher
    ..Contribution of ectopically expressed ?-tubulin2 in cancer growth was determined by depletion of ?-tubulin2. ..
  68. Herreros L, Rodríguez Fernandez J, Brown M, Alonso Lebrero J, Cabanas C, Sanchez Madrid F, et al. Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. J Biol Chem. 2000;275:26436-40 pubmed
  69. Haren L, Merdes A. Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. J Cell Sci. 2002;115:1815-24 pubmed
    ..Our results suggest that NuMA organises the poles by stable crosslinking of the microtubule fibers. ..
  70. Zhao J, Ren Y, Jiang Q, Feng J. Parkin is recruited to the centrosome in response to inhibition of proteasomes. J Cell Sci. 2003;116:4011-9 pubmed
    ..This process may provide a subcellular locale for parkin to ubiquitinate and degrade protein aggregates critically involved in the pathogenesis of Parkinson's disease. ..
  71. Goto M, Eddy E. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. J Biol Chem. 2004;279:42128-38 pubmed
  72. Matsumoto Y, Maller J. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Science. 2004;306:885-8 pubmed
    ..These results suggest that cyclin E has a modular centrosomal-targeting domain essential for promoting S phase entry in a Cdk2-independent manner. ..
  73. Giacca M. HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?. Retrovirology. 2005;2:7 pubmed
    ..Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis. ..
  74. Hubert T, Vandekerckhove J, Gettemans J. Cdk1 and BRCA1 target ?-tubulin to microtubule domains. Biochem Biophys Res Commun. 2011;414:240-5 pubmed publisher
    ..Tubulin itself has been reported to form complexes with DNA repair proteins in the nucleus. ..
  75. Brodie K, Henderson B. Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase. J Biol Chem. 2012;287:7701-16 pubmed publisher
    ..Moreover, Aurora A binding and phosphorylation of BRCA1 enhanced its centrosomal retention and regulation of centrosome amplification. Thus, CRM1, BARD1 and Aurora A promote the targeting and function of BRCA1 at centrosomes...
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