Gene Symbol: gamma-catenin
Description: junction plakoglobin
Alias: CTNNG, DP3, DPIII, PDGB, PKGB, junction plakoglobin, catenin (cadherin-associated protein), gamma 80kDa, desmoplakin III, desmoplakin-3
Species: human
Products:     gamma-catenin

Top Publications

  1. Maeda O, Usami N, Kondo M, Takahashi M, Goto H, Shimokata K, et al. Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line. Oncogene. 2004;23:964-72 pubmed
  2. Chen X, Bonne S, Hatzfeld M, van Roy F, Green K. Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem. 2002;277:10512-22 pubmed
  3. Aktary Z, Chapman K, Lam L, Lo A, Ji C, Graham K, et al. Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. Oncogene. 2010;29:2118-29 pubmed publisher
  4. Sacco P, McGranahan T, Wheelock M, Johnson K. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem. 1995;270:20201-6 pubmed
    ..Plakoglobin is an armadillo family member containing 13 weakly similar internal repeats. These data show that the alpha-catenin-binding region maps within the first repeat and the N-cadherin-binding region maps within repeats 7 and 8. ..
  5. Wei Q, Hariharan V, Huang H. Cell-cell contact preserves cell viability via plakoglobin. PLoS ONE. 2011;6:e27064 pubmed publisher
  6. Marcozzi C, Burdett I, Buxton R, Magee A. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion. J Cell Sci. 1998;111 ( Pt 4):495-509 pubmed
    ..Plakoglobin may function by potentiating dimer formation, accretion of dimers to cell-cell contact sites or desmosomal cadherin stability. ..
  7. Franke W, Goldschmidt M, Zimbelmann R, Mueller H, Schiller D, Cowin P. Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc Natl Acad Sci U S A. 1989;86:4027-31 pubmed
    ..7 kilobases) was detected in certain human tumor cell lines. This longer mRNA may be represented by a second type of plakoglobin cDNA, which contains an insertion of 297 nucleotides in the 3' non-coding region. ..
  8. Zheng X, Beissert T, Kukoc Zivojnov N, Puccetti E, Altschmied J, Strolz C, et al. Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood. 2004;103:3535-43 pubmed
    ..These data provide the first evidence that the aberrant activation of Wnt signaling by the AATP decisively contributes to the pathogenesis of AML. ..
  9. Bannon L, Cabrera B, Stack M, Green K. Isoform-specific differences in the size of desmosomal cadherin/catenin complexes. J Invest Dermatol. 2001;117:1302-6 pubmed

More Information


  1. Obama H, Ozawa M. Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). J Biol Chem. 1997;272:11017-20 pubmed
    ..7 x 10(-8), respectively). When transfected into L cells expressing E-cadherin, the amino-terminal region of alpha-catenin (from residue 1 to 226) formed complexes with beta-catenin supporting the in vitro binding experiment results. ..
  2. Aberle H, Bierkamp C, Torchard D, Serova O, Wagner T, Natt E, et al. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci U S A. 1995;92:6384-8 pubmed
    ..Our results, together with the present knowledge about the biological function of plakoglobin, suggest that plakoglobin might represent a putative tumor suppressor gene for breast and ovarian cancers. ..
  3. Kim Y, Ma H, Oehler V, Gang E, Nguyen C, Masiello D, et al. The gamma catenin/CBP complex maintains survivin transcription in ?-catenin deficient/depleted cancer cells. Curr Cancer Drug Targets. 2011;11:213-25 pubmed
    ..Therefore, we believe that the ability of ICG-001 to block both the CBP/?-catenin interaction and the CBP/?-catenin interaction may have clinical significance in cancers in which ?-catenin plays a significant transcriptional role. ..
  4. Yang Z, Bowles N, Scherer S, Taylor M, Kearney D, Ge S, et al. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006;99:646-55 pubmed
    ..These data suggest DSP expression in cardiomyocytes is crucial for maintaining cardiac tissue integrity, and DSP abnormalities result in ARVD/C by cardiomyocyte death, changes in lipid metabolism, and defects in cardiac development. ..
  5. Li D, Zhang W, Liu Y, Haneline L, Shou W. Lack of plakoglobin in epidermis leads to keratoderma. J Biol Chem. 2012;287:10435-43 pubmed publisher
    ..Our findings provide important insights for understanding the pathogenesis of human palmoplantar keratoderma. ..
  6. McKoy G, Protonotarios N, Crosby A, Tsatsopoulou A, Anastasakis A, Coonar A, et al. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet. 2000;355:2119-24 pubmed
    ..Therefore, the discovery of a mutation in a protein with functions in maintaining cell junction integrity has important implications for other dominant forms of ARVC, related cardiomyopathies, and other cutaneous diseases. ..
  7. Bailey C, Mittal M, Misra S, Chaudhuri G. High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG. J Biol Chem. 2012;287:19472-86 pubmed publisher
    ..Forced expression of plakoglobin in SLUG-high cells had the reverse effects on cellular motility. This study thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly disseminating breast cancer. ..
  8. Rieger Christ K, Ng L, Hanley R, Durrani O, Ma H, Yee A, et al. Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential. Br J Cancer. 2005;92:2153-9 pubmed
    ..These results show that plakoglobin acts as a tumour suppressor gene in bladder carcinoma cells and the silencing of plakoglobin gene expression in late-stage bladder cancer is a primary event in tumour progression. ..
  9. Asimaki A, Syrris P, Wichter T, Matthias P, Saffitz J, McKenna W. A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2007;81:964-73 pubmed
    ..These results implicate novel molecular mechanisms in the pathogenesis of ARVC...
  10. Huang H, Asimaki A, Lo D, McKenna W, Saffitz J. Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil Cytoskeleton. 2008;65:964-78 pubmed publisher
    ..These results indicate that different mutations in plakoglobin have markedly disparate effects on cell mechanical behavior, suggesting complex biomechanical roles for this protein. ..
  11. Roh J, Stanley J. Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. J Invest Dermatol. 1995;104:720-4 pubmed
    ..These results underscore the importance of a region, highly conserved in all desmogleins, in the carboxy terminus of the IC-cadherin-like subdomain for the localization of plakoglobin to desmosomes. ..
  12. Zhurinsky J, Shtutman M, Ben Ze ev A. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol. 2000;20:4238-52 pubmed
    ..These results suggest that overexpression of plakoglobin does not directly activate transcription and that formation of catenin-LEF-DNA complexes is negatively regulated by the catenin N- and C-terminal domains. ..
  13. Smith E, Fuchs E. Defining the interactions between intermediate filaments and desmosomes. J Cell Biol. 1998;141:1229-41 pubmed
    ..As epidermal cells differentiate, PP1 is added as a molecular reinforcement to the plaque, enhancing anchorage to IFs and accounting at least partially for the increase in numbers and stability of desmosomes in suprabasal cells. ..
  14. Franzen C, Todorovic V, Desai B, Mirzoeva S, Yang X, Green K, et al. The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling. PLoS ONE. 2012;7:e42132 pubmed publisher
  15. Kowalczyk A, Palka H, Luu H, Nilles L, Anderson J, Wheelock M, et al. Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability. J Biol Chem. 1994;269:31214-23 pubmed
    ..These results demonstrate that the desmosomal cadherins posttranslationally regulate plakoglobin expression by decreasing the rate of plakoglobin degradation. ..
  16. Fuchs M, Muller T, Lerch M, Ullrich A. Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J Biol Chem. 1996;271:16712-9 pubmed
  17. Kowalczyk A, Bornslaeger E, Borgwardt J, Palka H, Dhaliwal A, Corcoran C, et al. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol. 1997;139:773-84 pubmed
    ..These results identify a role for desmoplakin in organizing the desmosomal cadherin-plakoglobin complex and provide new insights into the hierarchy of protein interactions that occur in the desmosomal plaque. ..
  18. Lai Y, Cheng J, Cheng D, Feasel M, Beste K, Peng J, et al. SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells. BMC Cell Biol. 2011;12:50 pubmed publisher
    ..We have discovered that junction plakoglobin (JUP) interacts with SOX4 in both the cytosol and the nucleus and the interaction between SOX4 and ..
  19. Winn R, Bremnes R, Bemis L, Franklin W, Miller Y, Cool C, et al. gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth. Oncogene. 2002;21:7497-506 pubmed
    ..This study shows that gamma-catenin can function as an inhibitor of beta-catenin/TCF-dependent gene transcription and highlights gamma-catenin as a potentially novel tumor suppressor protein in a subset of human NSCLC cancers. ..
  20. Shiina H, Breault J, Basset W, Enokida H, Urakami S, Li L, et al. Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer. Cancer Res. 2005;65:2130-8 pubmed
    ..The gamma-catenin mutation related to Bcl-2 overexpression has a significant effect on the pathogenesis of HRPC. This is the first report to characterize the epigenetic and genetic regulation of gamma-catenin in human prostate cancer. ..
  21. Wahl J, Sacco P, McGranahan Sadler T, Sauppé L, Wheelock M, Johnson K. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. J Cell Sci. 1996;109 ( Pt 5):1143-54 pubmed
    ..One component of both adherens junctions and desmosomes is plakoglobin. In the adherens junction plakoglobin interacts with both the classical cadherin and with alpha-catenin...
  22. Pan H, Gao F, Papageorgis P, Abdolmaleky H, Faller D, Thiagalingam S. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression. Cancer Biol Ther. 2007;6:1638-43 pubmed
    ..In conclusion, our studies provide a molecular basis for the promotion of genomic instability and the oncogenic effects due to overexpression of gamma-catenin in human cancer. ..
  23. Miravet S, Piedra J, Miro F, Itarte E, Garcia de Herreros A, Duñach M. The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin. J Biol Chem. 2002;277:1884-91 pubmed
    ..These results indicate that Tcf-4 contains two different sites for binding of beta-catenin and plakoglobin, and the interaction of the latter hinders the transcriptional activity of the complex. ..
  24. Troyanovsky S, Troyanovsky R, Eshkind L, Leube R, Franke W. Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation. Proc Natl Acad Sci U S A. 1994;91:10790-4 pubmed
  25. Aktary Z, Kulak S, Mackey J, Jahroudi N, Pasdar M. Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3?. J Cell Sci. 2013;126:3031-42 pubmed publisher
  26. Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski Powitz A. M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells. Exp Cell Res. 1997;232:331-8 pubmed
    ..These results demonstrate that M-cadherin shares important features with the classical cadherins despite its phylogenetic divergence. ..
  27. Daniel J, Reynolds A. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol. 1995;15:4819-24 pubmed
    ..Hence, like beta-catenin and plakoglobin, CAS interacts directly with E-cadherin in vivo; however, unlike beta-catenin and plakoglobin, CAS does not interact with APC or alpha-catenin. ..
  28. Groeneweg J, Ummels A, Mulder M, Bikker H, van der Smagt J, van Mil A, et al. Functional assessment of potential splice site variants in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm. 2014;11:2010-7 pubmed publisher
    ..These results highlight the importance of functional assessment of potential splice site variants to improve patient care and facilitate cascade screening. ..
  29. Adedayo P, Wang S, Kunselman A, Undar A. Impact of Pulsatile Flow Settings on Hemodynamic Energy Levels Using the Novel Diagonal Medos DP3 Pump in a Simulated Pediatric Extracorporeal Life Support System. World J Pediatr Congenit Heart Surg. 2014;5:440-8 pubmed publisher
    The objective of this study was to evaluate the pump performance of the novel diagonal Medos Deltastream DP3 diagonal pump (MEDOS Medizintechnik AG, , Stolberg, Germany) under nonpulsatile to pulsatile mode with varying differential ..
  30. Kant S, Krusche C, Gaertner A, Milting H, Leube R. Loss of plakoglobin immunoreactivity in intercalated discs in arrhythmogenic right ventricular cardiomyopathy: protein mislocalization versus epitope masking. Cardiovasc Res. 2016;109:260-71 pubmed publisher
    ..Reduced plakoglobin staining in intercalated discs of heart tissue from human ARVC patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization. ..
  31. Protonotarios N, Tsatsopoulou A, Gatzoulis K. Arrhythmogenic right ventricular cardiomyopathy caused by a deletion in plakoglobin (Naxos disease). Card Electrophysiol Rev. 2002;6:72-80 pubmed
  32. Asimaki A, Protonotarios A, James C, Chelko S, Tichnell C, Murray B, et al. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016;9:e003688 pubmed publisher
    ..These cells may prove useful in future studies of disease mechanisms and drug screens for effective therapies in arrhythmogenic cardiomyopathy. ..
  33. Whittock N, Eady R, McGrath J. Genomic organization and amplification of the human plakoglobin gene (JUP). Exp Dermatol. 2000;9:323-6 pubmed
    ..We have also developed a PCR-based mutation detection strategy using primers placed on flanking introns followed by direct sequencing of the PCR products. ..
  34. Davidsson P, Broberg M, Kariola T, Sipari N, Pirhonen M, Palva E. Short oligogalacturonides induce pathogen resistance-associated gene expression in Arabidopsis thaliana. BMC Plant Biol. 2017;17:19 pubmed publisher
    ..To clarify the role of trimers (trimeric OGs, DP3) in DAMP signaling and their impact on plant growth regulation, we performed a transcriptomic analysis through the ..
  35. Agyekum I, Pepi L, Yu Y, Li J, Yan L, Linhardt R, et al. Structural elucidation of fucosylated chondroitin sulfates from sea cucumber using FTICR-MS/MS. Eur J Mass Spectrom (Chichester). 2017;:1469066717731900 pubmed publisher
    ..Mass spectrometry and tandem mass spectrometry data acquired for both species varying in oligomer length (dp3-dp15) are presented.
  36. Kudo I, Esumi M, Kusumi Y, Furusaka T, Oshima T. Particular gene upregulation and p53 heterogeneous expression in TP53-mutated maxillary carcinoma. Oncol Lett. 2017;14:4633-4640 pubmed publisher
  37. Ozawa M, Nuruki K, Toyoyama H, Ohi Y. Cloning of an alternative form of plakoglobin (gamma-catenin) lacking the fourth armadillo repeat. J Biochem. 1995;118:836-40 pubmed
    ..Therefore the variant form is most likely derived through alternative splicing of precursor RNA transcripts in an exon sequence. ..
  38. Aicher B, Lerch M, Muller T, Schilling J, Ullrich A. Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing. J Cell Biol. 1997;138:681-96 pubmed
  39. Hou J, Wang S, Jia M, Li D, Liu Y, Li Z, et al. A Systems Vaccinology Approach Reveals Temporal Transcriptomic Changes of Immune Responses to the Yellow Fever 17D Vaccine. J Immunol. 2017;199:1476-1489 pubmed publisher
    ..Overall, our findings indicate that YF-17D vaccination induces a prompt innate immune response and DC activation, a robust Ag-specific T cell response, and a persistent B cell/memory B cell response. ..
  40. Noorman M, Hakim S, Kessler E, Groeneweg J, Cox M, Asimaki A, et al. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2013;10:412-9 pubmed publisher
    ..Decreased levels of Nav1.5 might contribute to arrhythmia vulnerability and, in the future, potentially could serve as a new clinically relevant tool for risk assessment strategies. ..
  41. Gosavi P, Kundu S, Khapare N, Sehgal L, Karkhanis M, Dalal S. E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell Mol Life Sci. 2011;68:1439-54 pubmed publisher
    ..The results reported here are consistent with the model that PG and E-cadherin recruit PKP3 to the cell border to initiate desmosome formation. ..
  42. Kirchner F, Schuetz A, Boldt L, Martens K, Dittmar G, Haverkamp W, et al. Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations. Circ Cardiovasc Genet. 2012;5:400-11 pubmed publisher
  43. den Haan A, Tan B, Zikusoka M, Lladó L, Jain R, Daly A, et al. Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Cardiovasc Genet. 2009;2:428-35 pubmed publisher
    ..Compared with those without a desmosome gene mutation, individuals with a desmosome gene mutation had earlier-onset ARVD/C and were more likely to have ventricular tachycardia. ..
  44. Shafiei F, Rahnama F, Pawella L, Mitchell M, Gluckman P, Lobie P. DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells. Oncogene. 2008;27:2602-12 pubmed
    ..Autocrine hGH, therefore, utilizes DNA methylation as a mechanism to exert its oncogenic effects in mammary carcinoma cells. ..
  45. Polivka L, Bodemer C, Hadj Rabia S. Combination of palmoplantar keratoderma and hair shaft anomalies, the warning signal of severe arrhythmogenic cardiomyopathy: a systematic review on genetic desmosomal diseases. J Med Genet. 2016;53:289-95 pubmed publisher
    ..1%), always due to DSP mutations. Three mutation hotspots in DSP and JUP account for 90.8% of the patients with cardiac involvement. The combination of PPK and hair shaft anomalies justifies long-term cardiac monitoring. ..
  46. Mashchenko E, Amirkhanov K, Ozherelyev D. Morphology of a fossil elephant calf (Archidiskodon, Elephantidae) from the Oldowan Muhkai IIa site. Dokl Biol Sci. 2015;465:274-8 pubmed publisher
    ..A skull fragment and lower jaw with functioning teeth of the DP2/DP3 generation are preserved. The calf is at most 8-10 months of individual age...
  47. Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, et al. c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem Biophys Res Commun. 1995;208:1067-72 pubmed
    ..These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers. ..
  48. Munkholm J, Andersen C, Ottesen G. Plakoglobin: a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology?. Forensic Sci Med Pathol. 2015;11:47-52 pubmed publisher
    ..Our data suggests that immunostaining for plakoglobin might serve as an additional diagnostic marker of ARVC in forensic pathology, but additional validation is required. ..
  49. Basta Jovanovic G, Gvozdenovic E, Dimitrijevic I, Brasanac D, Jovanovic M, Kalezic N, et al. Immunohistochemical analysis of gamma catenin in Wilms' tumors. Fetal Pediatr Pathol. 2008;27:63-70 pubmed publisher
    ..In 2 metastatic cases and in the case of bilateral Wilms' tumor gamma-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of gamma-catenin and unfavorable outcome. ..
  50. Wahl J, Kim Y, Cullen J, Johnson K, Wheelock M. N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem. 2003;278:17269-76 pubmed
    ..These data suggest that a core N-cadherin-catenin complex assembles in the endoplasmic reticulum or Golgi compartment and is transported to the plasma membrane where linkage to the actin cytoskeleton can be established. ..
  51. Lau A, Mruk D. Rab8B GTPase and junction dynamics in the testis. Endocrinology. 2003;144:1549-63 pubmed
    ..Taken collectively, these studies suggest that Rab8B participates in adherens junction dynamics in the testis. ..
  52. Kodama S, Ikeda S, Asahara T, Kishida M, Kikuchi A. Axin directly interacts with plakoglobin and regulates its stability. J Biol Chem. 1999;274:27682-8 pubmed
    ..These results suggest that Axin regulates the stability of plakoglobin by enhancing its phosphorylation by GSK-3beta and that Axin may act on beta-catenin and plakoglobin in similar manners. ..
  53. Yamamoto M, Bharti A, Li Y, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem. 1997;272:12492-4 pubmed
    ..The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells. ..
  54. Christensen A, Benn M, Bundgaard H, Tybjaerg Hansen A, Haunso S, Svendsen J. Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2010;47:736-44 pubmed publisher
    ..Our study supports comprehensive desmosomal mutation screening beyond the first encountered mutation, whereas routine screening for genomic rearrangements does not seem indicated. ..
  55. Karmouch J, Zhou Q, Miyake C, Lombardi R, Kretzschmar K, Bannier Hélaouët M, et al. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017;121:1346-1359 pubmed publisher
    ..The findings offer a cellular basis for early cardiac arrhythmias in patients with arrhythmogenic cardiomyopathy and cardiocutaneous syndromes. ..
  56. Ielchishcheva I, Stachowiak B, Szwengiel A, Bozhkov A. Growth and carotenogenesis in Rhodosporidium diobovatum IMB Y-5023: Effects of culture medium and illumination intensity. FEMS Microbiol Lett. 2017;: pubmed publisher capable of assimilating oligosaccharides and can grow and produce carotenoids in low-glucose media containing DP3 and DP4. Moreover R...
  57. Shair K, Schnegg C, Raab Traub N. Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. Cancer Res. 2009;69:5734-42 pubmed publisher
    ..Low levels of plakoglobin were also detected in human NPC tissues. These findings reveal that the effects of LMP1 on junctional plakoglobin and the initiation of a cadherin switch likely contribute to metastasis of NPC. ..
  58. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, et al. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol. 1995;128:949-57 pubmed
  59. Cabral R, Liu L, Hogan C, Dopping Hepenstal P, Winik B, Asial R, et al. Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children. J Invest Dermatol. 2010;130:1543-50 pubmed publisher
    ..Our findings provide new insight into the distinct roles that PG has in the epidermis and heart. ..
  60. Wickline E, Du Y, Stolz D, Kahn M, Monga S. ?-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after ?-catenin knockdown. Neoplasia. 2013;15:421-34 pubmed
    ..Anti-?-catenin therapies for HCC affecting total ?-catenin may target aberrant Wnt signaling without negatively impacting intercellular adhesion, provided mechanisms leading to ?-catenin stabilization are spared...
  61. Koyama Nasu R, Takahashi R, Yanagida S, Nasu Nishimura Y, Oyama M, Kozuka Hata H, et al. The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels. PLoS ONE. 2013;8:e53710 pubmed publisher
    ..We speculate that CD133 may be a promising target for cancer chemotherapy. ..
  62. Alaee M, Padda A, Mehrabani V, Churchill L, Pasdar M. The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion. Oncotarget. 2016;7:26898-915 pubmed publisher
    ..The DNA-binding domain of p53 and C-terminal domain of PG mediated p53/PG interaction, and furthermore, the C-terminus of PG played a central role in the inhibition of invasion in association with p53. ..
  63. Zhao Y, Masiello D, McMillian M, Nguyen C, Wu Y, Melendez E, et al. CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells. Oncogene. 2016;35:3705-17 pubmed publisher
  64. Hu Y, Winter V, Chen X, Ganzle M. Effect of acceptor carbohydrates on oligosaccharide and polysaccharide synthesis by dextransucrase DsrM from Weissella cibaria. Food Res Int. 2017;99:603-611 pubmed publisher
    ..The efficiency of α-glucans as acceptor carbohydrates decreased in the order DP2>DP3>DP1; among disaccharides, the efficiency decreased in the order α-(1→6)>α-(1→4)>α-(1→3); the α-(..
  65. Nagel J, Kriegl L, Horst D, Engel J, Gautam S, Mantzoros C, et al. ?-Catenin is an independent prognostic marker in early stage colorectal cancer. Int J Colorectal Dis. 2010;25:1301-9 pubmed publisher
    ..Catenin may therefore serve as a marker for identifying patients who are at increased risk of disease recurrence who may benefit from closer follow-up and adjuvant therapy. ..
  66. Li Y, Hu K, Xiao X, Wu W, Yan H, Chen H, et al. FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation. Biochem Biophys Res Commun. 2018;497:473-479 pubmed publisher
  67. Ashihara K, Saito T, Mizumoto H, Adachi K, Tanaka R, Nishimura M, et al. Loss of gamma-Catenin expression in squamous differentiation in endometrial carcinomas. Int J Gynecol Pathol. 2002;21:246-54 pubmed
    ..Our results suggest that unique molecular events, i.e., stimulation of beta-catenin and suppression of gamma-catenin expression, occur within endometrial carcinomas with squamous differentiation. ..
  68. Peters S. Early and late manifestation of Brugada syndrome ECG in arrhythmogenic cardiomyopathy. Int J Cardiol. 2016;220:260-1 pubmed publisher
  69. Aoyama Y, Yamamoto Y, Yamaguchi F, Kitajima Y. Low to high Ca2+ -switch causes phosphorylation and association of desmocollin 3 with plakoglobin and desmoglein 3 in cultured keratinocytes. Exp Dermatol. 2009;18:404-8 pubmed
    ..These results suggest that both the binding of Dsc3 to plakoglobin and Dsc3 phosphorylation are involved in Dsc3 binding to Dsg3 during Ca2+ -induced desmosome assembly. ..
  70. Aktary Z, Pasdar M. Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. PLoS ONE. 2013;8:e78388 pubmed publisher
    ..Together with the results of our previous studies, the data suggests that plakoglobin suppresses tumorigenesis and metastasis through the regulation of genes involved in these processes. ..
  71. Cooksley Decasper S, Reiser H, Thommen D, Biedermann B, Neidhart M, Gawinecka J, et al. Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. PLoS ONE. 2012;7:e47985 pubmed publisher
    ..One of them, junction plakoglobin (JUP-81) and its smaller isoforms (referred to as JUP-63, JUP-55 and JUP-30 by molecular weight) were ..
  72. Huber A, Weis W. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell. 2001;105:391-402 pubmed
    ..APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly. ..
  73. Chidiac R, Zhang Y, Tessier S, Faubert D, Delisle C, Gratton J. Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation. Mol Cell Proteomics. 2016;15:1511-25 pubmed publisher
    ..In conclusion, we uncovered ZO-1 as part of a signaling node activated by VEGF, but not Ang-1, that specifically modulates EC proliferation during angiogenesis. ..
  74. Holsinger L, Ward K, Duffield B, Zachwieja J, Jallal B. The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). Oncogene. 2002;21:7067-76 pubmed
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