Galpha13

Summary

Gene Symbol: Galpha13
Description: G protein subunit alpha 13
Alias: G13, guanine nucleotide-binding protein subunit alpha-13, g alpha-13, guanine nucleotide binding protein (G protein), alpha 13
Species: human
Products:     Galpha13

Top Publications

  1. Sheu Gruttadauria J, Xiao Y, Gebert L, Macrae I. Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. EMBO J. 2019;: pubmed publisher
    ..of human Argonaute2 (Ago2) engaged with a target RNA recognized through both miRNA seed and supplementary (g13-g16) regions. Ago2 creates a "supplementary chamber" that accommodates up to five miRNA-target base pairs...
  2. Dogan S, Shen R, Ang D, Johnson M, D Angelo S, Paik P, et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res. 2012;18:6169-77 pubmed publisher
    ..We genotyped 3,026 lung adenocarcinomas for the major EGFR (exon 19 deletions and L858R) and KRAS (G12, G13) mutations and examined correlations with demographic, clinical, and smoking history data...
  3. Yang X, Mou Y, Wang Y, Wang J, Li Y, Kong R, et al. Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitors⁻Indocyanine Dyes Conjugates as Targeted Antitumor Agents. Molecules. 2019;24: pubmed publisher
    ..The synthesized compounds G1G13 were evaluated in vitro for their cytotoxicity against PC-3 cells using the MTT assay, and molecular docking ..
  4. González Farre B, Ramis Zaldivar J, Salmeron Villalobos J, Balague O, Celis V, Verdu Amoros J, et al. Burkitt-like lymphoma with 11q aberration: A germinal center derived lymphoma genetically unrelated to Burkitt lymphoma. Haematologica. 2019;: pubmed publisher
    ..These results suggest that Burkitt-like lymphoma with 11q aberration is a germinal center derived lymphoma closer to high grade B-cell lymphoma or diffuse large B-cell lymphoma rather than Burkitt lymphoma. ..
  5. Proroga Y, Mancusi A, Peruzy M, Carullo M, Montone A, Fulgione A, et al. Characterization of Salmonella Typhimurium and its monophasic variant 1,4, [5],12:i:- isolated from different sources. Folia Microbiol (Praha). 2019;: pubmed publisher
    ..by means of the Kirby-Bauer disk-diffusion method, and for the detection of 19 genes (four Phage Markers (g13, Sieb, eat, g8), ten prophage-related virulence genes (gipA, gtgB, nanH, gogB, grvA, sopE, sspH1, sspH2, sodC1, ..
  6. Sriwai W, Mahavadi S, Al Shboul O, Grider J, Murthy K. Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA. PLoS ONE. 2013;8:e66743 pubmed publisher
    ..The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated Gq, G13, Gi1, PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation...
  7. Gardner J, Ha J, Jayaraman M, Dhanasekaran D. The gep proto-oncogene G?13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells. Pancreas. 2013;42:819-28 pubmed publisher
    ..These findings identify LPA-lysophosphatidic acid receptor-G?13 signaling node as a novel therapeutic target for pancreatic cancer treatment and control. ..
  8. Li J, Dai Y, Lilljebjörn H, Shen S, Cui B, Bai L, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A. 2018;115:E11711-E11720 pubmed publisher
    ..N159Y), respectively; G12 with IGH-CEBPE fusion and mutations in ZEB2 (p.H1038R); and G13 and G14 with TCF3/4-HLF and NUTM1 fusions, respectively...
  9. Gao W, Wang Y, Xiong Y, Sun L, Wang L, Wang K, et al. Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury. Acta Biomater. 2019;85:203-217 pubmed publisher
    ..activity on TLR4 activation and its downstream cytokine production among those with a GNP core of 13 nm (P12(G13)) and 5 nm (P12(G5)) in THP-1 cell-derived macrophages...

More Information

Publications165 found, 100 shown here

  1. Meyer B, Freuler F, Guerini D, Siehler S. Reversible translocation of p115-RhoGEF by G(12/13)-coupled receptors. J Cell Biochem. 2008;104:1660-70 pubmed publisher
    ..The translocation of RhoGEF by G(12/13)-linked GPCRs can be quantified and therefore used for pharmacological studies of the pathway, and to discover active compounds in a G(12/13)-related disease context. ..
  2. Wagener R, Seufert J, Raimondi F, Bens S, Kleinheinz K, Nagel I, et al. The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. 2018;: pubmed publisher
    ..Our findings implicate that mnBLL,11q, is a lymphoma category distinct from Burkitt lymphoma at the molecular level. ..
  3. Yamaguchi Y, Katoh H, Mori K, Negishi M. Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol. 2002;12:1353-8 pubmed
    ..5-fold. Moreover, we demonstrate that the active form of Galpha(12) translocates PP5 to the cell periphery and colocalizes with PP5. These results propose a new signaling pathway of G(12) family G proteins. ..
  4. Kawamura T, Hirata A, Ohno S, Nomura Y, Nagano T, Nameki N, et al. Multisite-specific archaeosine tRNA-guanine transglycosylase (ArcTGT) from Thermoplasma acidophilum, a thermo-acidophilic archaeon. Nucleic Acids Res. 2016;44:1894-908 pubmed publisher
    ..In contrast, T. acidophilum cell extract exchanged both G13 and G15 bases. Because T...
  5. Bhattacharyya R, Wedegaertner P. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. J Biol Chem. 2000;275:14992-9 pubmed
    ..These findings identify palmitoylation of alpha(13) as critical for its proper membrane localization and signaling and provide insight into the mechanism of activation of Rho-dependent signaling pathways by alpha(13). ..
  6. He F, Chen L, Liu Q, Wang X, Li J, Yu J. Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography Coupled with Ultrahigh Pressure Extraction. Molecules. 2018;23: pubmed publisher
    ..b>3), and acteoside (6), and three secoiridoid glycosides, isonuezhenide (2), nuezhenoside G13 (4), and specnuezhenide (5), have been extracted and separated by a combined method of ultrahigh ..
  7. Fujii T, Barzi A, Sartore Bianchi A, Cassingena A, Siravegna G, Karp D, et al. Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers. Clin Cancer Res. 2017;23:3657-3666 pubmed publisher
    ..Design: A quantitative, mutation-enrichment next-generation sequencing test for detecting KRASG12/G13 mutations in urine cfDNA was developed, and results were compared with clinical testing of archival tumor ..
  8. Ponimaskin E, Behn H, Adarichev V, Voyno Yasenetskaya T, Offermanns S, Schmidt M. Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation. FEBS Lett. 2000;478:173-7 pubmed
  9. Kyi C, Key S, Lloyd T. Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm. Int J Oral Maxillofac Surg. 2003;32:337-8 pubmed
    ..This reduces tissue damage, enhances patient compliance and could improve the overall success rate of the technique. ..
  10. Brulé C, Perzo N, Joubert J, Sainsily X, Leduc R, Castel H, et al. Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J. 2014;28:5148-62 pubmed publisher
    ..The activated receptor coupled to Gi1, GoA, Gq, and G13, excluding Gs, and recruited β-arrestins 1 and 2...
  11. Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokita R, Minami S, et al. Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface. J Biol Chem. 2009;284:5000-9 pubmed publisher
    ..We propose that LARG activation is regulated by an induced-fit mechanism through the GAP interface of Galpha(13). ..
  12. Parker J, Mattos C. The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic Domain. Mol Cancer Res. 2015;13:595-603 pubmed publisher
    The small GTPase Ras is mutated in about 20% of human cancers, primarily at active site amino acid residues G12, G13, and Q61...
  13. Ilm K, Kemmner W, Osterland M, Burock S, Koch G, Herrmann P, et al. High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients. Mol Cancer. 2015;14:38 pubmed publisher
    ..survival analyses of MACC1 expression with any of the markers KRAS mutated in codon 12 (KRAS G12) or codon 13 (KRAS G13), BRAF V600 mutation and MSI status in a retrospective study of 99 CRC patients with tumors UICC staged I, II and ..
  14. Zhou Y, Liu W, Xu Z, Zhu H, Xiao D, Su W, et al. Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes. Neoplasia. 2018;20:1059-1069 pubmed publisher
  15. Carroll P, Muwanguzi Karugaba J, Parish T. Codon-optimized DsRed fluorescent protein for use in Mycobacterium tuberculosis. BMC Res Notes. 2018;11:685 pubmed publisher
    ..under the control of one of three strong, constitutive promoters (Phsp60, PrpsA or PG13) for use in mycobacteria...
  16. Fang J, Imran M, Hu W, Ojcius D, Li Y, Ge Y, et al. vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation. EBioMedicine. 2018;37:428-441 pubmed publisher
    ..b>G13/R36/G47 in Lep-vWA-I and G76/Q126 in Lep-vWA-II were confirmed as the Hu-GPIbα-binding sites...
  17. Schuhmacher M, Kudithipudi S, Kusevic D, Weirich S, Jeltsch A. Activity and specificity of the human SUV39H2 protein lysine methyltransferase. Biochim Biophys Acta. 2015;1849:55-63 pubmed publisher
    ..on H3 comprising T6-K14, with highly specific readout of R8, S10, T11 and G12 and partial specificity at T6, A7, G13 and K14...
  18. Lecointre C, Desrues L, Joubert J, Perzo N, Guichet P, Le Joncour V, et al. Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene. 2015;34:5080-94 pubmed publisher
    ..These effects mainly involved the G13/Rho/rho kinase pathway while partially requiring Gi/o/PI3K components...
  19. Geißler A, Geißler M, Kottmann D, Lutz L, Fichter C, Fritsch R, et al. ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer. Oncotarget. 2017;8:17164-17190 pubmed publisher
    ..In fact, EGFR-targeted treatment responses were also observed in RAS exon 2 p.G13 mutated CRC cell lines or CRC cases and were further linked to PIK3CA exon 9 mutations...
  20. Hirayama Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, et al. Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics. J Proteomics. 2017;158:31-42 pubmed publisher
    ..Our results provide a novel insight into schizophrenia pathology, and could be helpful for drug development. ..
  21. Wu Z, Li X, Zhang Y, Tong D, Wang L, Zhao P. Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats: Beneficial Effects of Maternal Exercise. Front Cell Neurosci. 2018;12:122 pubmed publisher
    ..rats were exposed to 3% sevoflurane for 2 h on gestational (G) day 14, or to sequential exposure for 2 h on G13, G14 and G15...
  22. Martinetti D, Costanzo R, Kadare S, Alimehmeti M, Colarossi C, Canzonieri V, et al. KRAS and BRAF mutational status in colon cancer from Albanian patients. Diagn Pathol. 2014;9:187 pubmed publisher
    ..Out of the 159 cases, 28 (17,6%) showed KRAS mutation (13 G12D, 4 G12C, 4 G12V, 3 G12A, 2 G13 D, 1 G12S and 1 A146T), and 10 (6,3%) showed BRAF mutation (all V600E)...
  23. Mathieu Y, Piumi F, Valli R, Aramburu J, Ferreira P, Faulds C, et al. Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass. Appl Environ Microbiol. 2016;82:2411-2423 pubmed publisher
    ..Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions...
  24. Lim Y, Ovejero D, Derrick K, Collins M, Choate K. Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy. J Am Acad Dermatol. 2016;75:420-7 pubmed publisher
    ..Our new case harbored somatic activating HRAS p.G13 R mutation in affected tissue, consistent with previous findings...
  25. Liu W, Li H, Wang Y, Zhao X, Guo Y, Jin J, et al. MiR-30b-5p functions as a tumor suppressor in cell proliferation, metastasis and epithelial-to-mesenchymal transition by targeting G-protein subunit ?-13 in renal cell carcinoma. Gene. 2017;626:275-281 pubmed publisher
    ..Therefore, miR-30b-5p may be considered a potential biomarker for the diagnosis of RCC. ..
  26. Srinivasan S, Schiemer J, Zhang X, Chishti A, Le Breton G. Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets. J Biol Chem. 2015;290:25129-39 pubmed publisher
    ..Based on the limited scope of this involvement, and the known importance of G13 in hemostasis and thrombosis, the present study examined whether signaling through another switch region of G13, i...
  27. Braggio E, Van Wier S, Ojha J, McPhail E, Asmann Y, Egan J, et al. Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas. Clin Cancer Res. 2015;21:3986-94 pubmed publisher
    ..In summary, genome-wide analysis uncovered novel recurrent alterations, including TOX and PRKCD, helping to differentiate PCNSL from systemic DLBCL and related lymphomas. ..
  28. Shahriari Z, Heidari B, Dadkhodaie A. Dissection of genotype × environment interactions for mucilage and seed yield in Plantago species: Application of AMMI and GGE biplot analyses. PLoS ONE. 2018;13:e0196095 pubmed publisher
    ..psyllium), G1, G2 and G4 (P. major), G9 and G10 (P. officinalis) and P. lanceolata were identified as stable. G13 (P. ovata), G5 and G6 (P. major) and G30 (P. lagopus) had higher stability for mucilage content...
  29. Yagi H, Tan W, Dillenburg Pilla P, Armando S, Amornphimoltham P, Simaan M, et al. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011;4:ra60 pubmed publisher
    ..Multiple complementary experimental strategies, including synthetic biology approaches, indicated that signaling-selective inhibition of the CXCR4-Gα(13)-Rho axis prevents the metastatic spread of basal-like breast cancer cells. ..
  30. Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N. Involvement of aquaporin in thromboxane A2 receptor-mediated, G 12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells. Cell Signal. 2010;22:41-6 pubmed publisher
    ..This is the first report that the TXA(2) receptor mediates water influx through aquaporins in astrocytoma cells via TXA(2) receptor-mediated activation of G alpha(12/13), Rho A, Rho kinase and Na(+)/H(+)-exchanger. ..
  31. Kutuzov M, Andreeva A, Voyno Yasenetskaya T. Regulation of apoptosis signal-regulating kinase 1 degradation by G alpha13. FASEB J. 2007;21:3727-36 pubmed
    ..We have shown previously that alpha subunits of heterotrimeric G12 and G13 proteins stimulate ASK1 kinase activity and ASK1-dependent apoptosis...
  32. Zhang L, Zhai X, Liu Y, Li J, Shan Z, Teng W. Treatment with Iodine in Pregnant Rats with Marginal Iodine Deficiency Improves Cell Migration in the Developing Brain of the Progeny. Mol Neurobiol. 2016;53:2212-21 pubmed publisher
    ..we established a marginal iodine deficiency model, and iodine supplement was performed on pre-pregnancy (PP), G13 (gestation day 13), and postnatal day 0 (P0)...
  33. Lu S, Jang H, Nussinov R, Zhang J. The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. Sci Rep. 2016;6:21949 pubmed publisher
    Ras mediates cell proliferation, survival and differentiation. Mutations in K-Ras4B are predominant at residues G12, G13 and Q61...
  34. Cai Y, Guo Y, Li Z, Wu D, Li X, Zhang H, et al. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur J Med Chem. 2016;114:134-40 pubmed publisher
    ..Here, we report the isolation and characterization of 13 compounds (G1-G13) by bioassay-guided fractionation of the ethyl acetate extraction of Gaultheria yunnanensis (FRANCH...
  35. Jin S, Exton J. Activation of RhoA by association of Galpha(13) with Dbl. Biochem Biophys Res Commun. 2000;277:718-21 pubmed
    ..These findings illustrate that activated Galpha(13) and Dbl can associate in vivo and that this leads to Rho activation. ..
  36. Meigs T, Fields T, McKee D, Casey P. Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. Proc Natl Acad Sci U S A. 2001;98:519-24 pubmed
    The G12 subfamily of heterotrimeric G proteins, comprised of the alpha-subunits Galpha12 and Galpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis...
  37. Baudouin A, Diouf E, Tall M, Duval S, Provôt S, Picaud J, et al. [Advantages and special features of hospital preparations of parenteral nutrition in neonatalogy]. Ann Pharm Fr. 2015;73:150-9 pubmed publisher
    ..formulations NP 100®, Pediaven AP-HP Nouveau-né 1®, Pediaven AP-HP Nouveau-né 2® and Numetah G13% E® and of two hospital preparations made specifically in hospital pharmacies produced by two separate ..
  38. Justus C, Yang L. GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway. Exp Cell Res. 2015;334:100-13 pubmed publisher
    ..Altogether our results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling. ..
  39. Niira K, Ito M, Masuda T, Saitou T, Abe T, Komoto S, et al. Whole genome sequences of Japanese porcine species C rotaviruses reveal a high diversity of genotypes of individual genes and will contribute to a comprehensive, generally accepted classification system. Infect Genet Evol. 2016;44:106-113 pubmed publisher
    ..from healthy pigs were highly divergent from other known RVC strains and were provisionally classified as G12 and G13 based on the 86% nucleotide identity cut-off value...
  40. Lagestad P, Steen I, Dalen T. Inevitable Relative Age Effects in Different Stages of the Selection Process among Male and Female Youth Soccer Players. Sports (Basel). 2018;6: pubmed publisher
    ..We also aimed to investigate the RAE during the three different selection stages for B13, B14 (boys), and G13, G14 (girls), and gender differences in the RAE...
  41. Ren Y, Zhao X, Yang T, Duan Y, Sun Y, Zhao W, et al. Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling. Yonsei Med J. 2018;59:760-768 pubmed publisher
    ..The results of the present study provide a comprehensive understanding of the roles of DEGs in knee cartilage in relation to the development of OA. ..
  42. Agarwal N, Kim C, Kunkalla K, Konno H, Tjendra Y, Kwon D, et al. Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood. 2016;127:605-15 pubmed publisher
    ..By linking IKKβ-mediated nuclear factor-κB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
  43. Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E, Pettirossi V, et al. Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. Blood. 2018;: pubmed publisher
  44. Roland A, Ricobaraza A, Carrel D, Jordan B, Rico F, Simon A, et al. Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth. elife. 2014;3:e03159 pubmed publisher
    ..by endo- or exocannabinoids such as the marijuana component ∆(9)-tetrahydrocannabinol, to heterotrimeric G12/G13 proteins that triggers rapid and reversible non-muscle myosin II (NM II) dependent contraction of the actomyosin ..
  45. Brydon L, Roka F, Petit L, de Coppet P, Tissot M, Barrett P, et al. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Mol Endocrinol. 1999;13:2025-38 pubmed
    ..We show that Mel 1a receptors functionally couple to both PTX-sensitive and PTX-insensitive G proteins. The previously unknown signaling of Mel 1a receptors through G(q/11) widens the spectrum of potential targets for melatonin. ..
  46. Juneja J, Casey P. Role of G12 proteins in oncogenesis and metastasis. Br J Pharmacol. 2009;158:32-40 pubmed publisher
  47. Zhang J, Mai S, Huang X, Wang F, Liao Y, Lin M, et al. MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling. Ann Oncol. 2014;25:2196-204 pubmed publisher
    ..Our findings highlight the important role of miR-29c in regulating CRC EMT via GSK-3β/β-catenin signaling by targeting GNA13 and PTP4A and provide new insights into the metastatic basis of CRC. ..
  48. Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed publisher
  49. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno Yasenetskaya T. Conformational activation of radixin by G13 protein alpha subunit. J Biol Chem. 2000;275:26206-12 pubmed
    ..Our results identifying a new signaling pathway for Galpha(13) indicate that ERM proteins can be activated by and serve as effectors of heterotrimeric G proteins. ..
  50. Liu M, Xu Z, Du Z, Wu B, Jin T, Xu K, et al. The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis. J Immunol Res. 2017;2017:1278081 pubmed publisher
    ..The results suggested that CDK17, GNA13, PHF21A, and MTHFD2 might play important roles and potentially be valuable in the prognosis and treatment of glioma. ..
  51. Jiang L, Collins J, Davis R, Fraser I, Sternweis P. Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII. J Biol Chem. 2008;283:23429-39 pubmed publisher
    ..Our results demonstrate that AC7 is a specific downstream effector of the G(12/13) pathway. ..
  52. Liu G, Han J, Profirovic J, Strekalova E, Voyno Yasenetskaya T. Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis. Angiogenesis. 2009;12:1-15 pubmed publisher
    ..Science 275:533-536, 1997). However, the molecular mechanism of Galpha13-dependent angiogenesis is not understood...
  53. Feng X, Liu X, Lu S, Ren H, Li Y, Hu P, et al. Expression, purification and characterization of recombinant toxins consisting of truncated gastrin 17 and pseudomonas exotoxin. Protein Pept Lett. 2015;22:193-201 pubmed
    ..Four recombinant Pseudomonas toxins PE38 fused with the forward or reverse truncated forms of G17 (G14 and G13) were successfully constructed, expressed, and purified...
  54. Afzal M, Shad S. Characterization of Phenacoccus solenopsis (Tinsley) (Homoptera: Pseudococcidae) Resistance to Emamectin Benzoate: Cross-Resistance Patterns and Fitness Cost Analysis. Neotrop Entomol. 2016;45:310-9 pubmed publisher
    ..decline in emamectin resistance was observed in the resistant population when not exposed to emamectin from G7 to G13. The estimated realized heritability (h (2)) for emamectin resistance was 0.84...
  55. Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, et al. Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses. PLoS ONE. 2015;10:e0129334 pubmed publisher
    ..receptor (GPCR) coupling to multiple intracellular signaling pathways, including the Gs protein/cAMP and G13 protein/Rho...
  56. O Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis C, Drummond R, et al. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016;35:3771-80 pubmed publisher
  57. Longest P, Hindle M. Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition. Pharm Res. 2017;34:2049-2065 pubmed publisher
    ..dissolution, absorption and clearance occurring in the surface liquid of a representative small airway generation (G13) was developed and used to evaluate epithelial dose for the same deposited drug mass of conventional microparticles,..
  58. Quoyer J, Janz J, Luo J, Ren Y, Armando S, Lukashova V, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013;110:E5088-97 pubmed publisher
    ..pepducin, ATI-2341, on the ability of the receptor to engage the inhibitory G proteins (Gi1, Gi2 and Gi3), G13, and ?-arrestins...
  59. Badalamenti J, Bond D. Complete Genome of Geobacter pickeringii G13T, a Metal-Reducing Isolate from Sedimentary Kaolin Deposits. Genome Announc. 2015;3: pubmed publisher
    We used PacBio sequencing to assemble the genome of the pristine freshwater isolate Geobacter pickeringii G13(T) into a single 3,618,700-bp circular chromosome polished to 99.999% accuracy (quality value [QV], 50)...
  60. Zhang J, Yun M, Xu Y, Chen J, Weng H, Zheng Z, et al. GNA13 as a prognostic factor and mediator of gastric cancer progression. Oncotarget. 2016;7:4414-27 pubmed publisher
    ..Our present study illustrated that GNA13 has an important role in promoting proliferation and tumorigenicity of GC, and may represent a novel prognostic biomarker and therapeutic target for this disease. ..
  61. Lee S, Huang K. Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia. BMC Med Genomics. 2016;9:68 pubmed publisher
    ..The SDMG promoters are predominantly hypomethylated. Increasing methylation on these promoters is proposed as a novel therapeutic approach for schizophrenia. ..
  62. Gong H, Shen B, Flevaris P, Chow C, Lam S, Voyno Yasenetskaya T, et al. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science. 2010;327:340-3 pubmed publisher
    ..We found that the heterotrimeric guanine nucleotide-binding protein (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-integrin interaction was promoted by ..
  63. Muppidi J, Lu E, Cyster J. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015;212:2213-22 pubmed publisher
  64. Siehler S. Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol. 2009;158:41-9 pubmed publisher
    ..The review gives an overview of G(12/13) signalling of GPCRs with a focus on RhoGEF proteins as the immediate mediators of G(12/13) activation. ..
  65. M Kadmi C, Leyris J, Onfroy L, Galés C, Saulière A, Gagne D, et al. Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling. J Biol Chem. 2015;290:27021-39 pubmed publisher
    ..GHS-R1a signals through Gq, Gi/o, G13, and arrestin...
  66. Yagi H, Asanoma K, Ohgami T, Ichinoe A, Sonoda K, Kato K. GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer. Oncogene. 2016;35:4471-80 pubmed publisher
    ..Furthermore, we reveal that inhibition of YAP by short hairpin RNA or a specific inhibitor prevented the growth of ovarian cancer cells. Therefore, YAP may be a suitable therapeutic target in ovarian cancer. ..
  67. Udayappan U, Casey P. c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells. Molecules. 2017;22: pubmed publisher
    ..Understanding the mechanisms by which GNA12 expression is controlled may aid in the development of therapies that target key elements responsible for GNA12-mediated tumor progression. ..
  68. Kilts J, Lin S, Lowe J, Kwatra M. Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors. J Cardiovasc Pharmacol. 2007;50:299-303 pubmed
    ..These receptors have also been shown to couple to G proteins of the G12 family, including Galpha12 and Galpha13. In this report, we determined whether these G proteins interact with endothelin, angiotensin, and alpha1-..
  69. Huang Y, Su Y, Chang C, Sun W. Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals. J Recept Signal Transduct Res. 2016;36:633-644 pubmed
    ..4 ? 6.8, are important to pH homeostasis, immune responses and acid-induced pain. Although G2A mediates the G13-Rho pathway in response to acid, whether G2A activates Gs, Gi or Gq proteins remains debated...
  70. Rasheed S, Leong H, Lakshmanan M, Raju A, Dadlani D, Chong F, et al. GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. Oncogene. 2018;37:1340-1353 pubmed publisher
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    ..Thus, GNA13 loss is associated with GC B-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development. ..
  72. Wagner M, da Rosa R, de Figueiredo J, Duarte M, Pereira J, Só M. Final irrigation protocols may affect intraradicular dentin ultrastructure. Clin Oral Investig. 2017;21:2173-2182 pubmed publisher
    ..9% saline by 2.5% NaOCl; and G10 to G13 by 2% CHX. One-half of each sample was prepared and evaluated using SEM and the other one by TEM observations...
  73. Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A. Clr4 specificity and catalytic activity beyond H3K9 methylation. Biochimie. 2017;135:83-88 pubmed publisher
    ..In addition, it exhibits specific contacts at the S10, T11, G12 and G13 positions of the H3 peptide recognizing an R-K-SKRT-TCS-G sequence...
  74. Zhou M, Wang M, Xue L, Lin Z, He Q, Shi W, et al. A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR). J Biol Chem. 2017;292:13934-13946 pubmed publisher
    ..a highly conserved uridine at position 22 at the D-stem of tRNALeu(UUR), introducing a G-C base pairing (G13-C22) at the D-stem and a tertiary base pairing (C22-G46) between the D-stem and the variable loop...
  75. Dorsam R, Kim S, Jin J, Kunapuli S. Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem. 2002;277:47588-95 pubmed
  76. Vilar M, Peralta B, García Bocanegra I, Simon Grifé M, Bensaid A, Casal J, et al. Distribution and genetic characterization of Enterovirus G and Sapelovirus A in six Spanish swine herds. Virus Res. 2016;215:42-9 pubmed publisher
    ..EV-G indicated circulation of diverse strains in the same farm, related to genotypes G1, G2, G3, G4, G6, G9, G12, G13 and G14...
  77. Janku F, Huang H, Fujii T, Shelton D, Madwani K, Fu S, et al. Multiplex KRASG12/G13 mutation testing of unamplified cell-free DNA from the plasma of patients with advanced cancers using droplet digital polymerase chain reaction. Ann Oncol. 2017;28:642-650 pubmed publisher
    ..of unamplified plasma cfDNA from 121 patients with diverse progressing advanced cancers were tested with a KRASG12/G13 multiplex assay to detect the seven most common mutations in the hotspot of exon 2 using droplet digital polymerase ..
  78. Yamakaw K, Kitamura K, Nonoguchi H, Takasu N, Miller R, Tomita K. Galpha13 induces preproET-1 gene expression via JNK. Hypertens Res. 2002;25:427-32 pubmed
    ..We previously reported that the ET(B)R interacts with Galpha13, a member of the heterotrimeric GTP-binding protein family...
  79. Grzelinski M, Pinkenburg O, Buch T, Gold M, Stohr S, Kalwa H, et al. Critical role of G(alpha)12 and G(alpha)13 for human small cell lung cancer cell proliferation in vitro and tumor growth in vivo. Clin Cancer Res. 2010;16:1402-15 pubmed publisher
    ..Due to the complete abolishment of tumorgenicity in our study, RNAi-mediated double knockdown may provide a promising new avenue in SCLC treatment. ..
  80. dos Santos J, Mangolin C, Machado M, Scapim C, Giordani W, Gonçalves L. Genetic variability among elite popcorn lines based on molecular and morphoagronomic characteristics. Genet Mol Res. 2017;16: pubmed publisher
    ..The lines G3, G4, G11, and G13 exhibited favorable morphological characters and low disease incidence rates...
  81. Bartolomé R, Díaz Martínez M, Colo G, Arellano Sánchez N, Torres Ayuso P, Kleinovink J, et al. A Blk-p190RhoGAP signaling module downstream of activated G?13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion. Cell Signal. 2014;26:2551-61 pubmed publisher
    ..Therefore, when G?13 is concurrently stimulated with CXCL12 there appears to be sufficient Blk activity to promote adequate levels of p190RhoGAP tyrosine phosphorylation to inactivate RhoA and to impair cell invasiveness. ..
  82. Yamaguchi Y, Katoh H, Negishi M. N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors. J Biol Chem. 2003;278:14936-9 pubmed
    ..Thus, N-terminal short sequences of the G(12) family determine the selective couplings of thrombin and LPA receptors to the Galpha(12) family. ..
  83. Stark M, Tom L, Boyle G, Bonazzi V, Soyer H, Herington A, et al. The "melanoma-enriched" microRNA miR-4731-5p acts as a tumour suppressor. Oncotarget. 2016;7:49677-49687 pubmed publisher
    ..We therefore speculate that loss of miR-4731 expression in stage IV patient tumours supports melanoma growth by, in part; reducing its regulatory control of SSX expression levels. ..
  84. Hot B, Valnohova J, Arthofer E, Simon K, Shin J, Uhlen M, et al. FZD10-G?13 signalling axis points to a role of FZD10 in CNS angiogenesis. Cell Signal. 2017;32:93-103 pubmed publisher
  85. Juskevicius D, Jucker D, Klingbiel D, Mamot C, Dirnhofer S, Tzankov A. Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort. J Hematol Oncol. 2017;10:70 pubmed publisher
    ..ClinicalTrials.gov NCT00544219. ..
  86. Ardawatia V, Masià Balagué M, Krakstad B, Johansson B, Kreitzburg K, Spriet E, et al. G?(12) binds to the N-terminal regulatory domain of p120(ctn), and downregulates p120(ctn) tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism. Exp Cell Res. 2011;317:293-306 pubmed publisher
    ..G?(12) emerges as an important regulator of p120(ctn) function, and possibly of cadherin-mediated adhesion and/or cell motility. ..
  87. Ma Y. Identification of G and P genotype-specific motifs in the predicted VP7 and VP4 amino acid sequences. Virus Res. 2015;210:271-8 pubmed publisher
    ..Its genotype constellations were determined as G13-P[18]-I6-R9-C9-M6-A6-N9-T12-E14-H11, confirming previous genotype assignments...
  88. Che Y, Lu Y, Zha X, Huang H, Yang P, Ma L, et al. Higher efficiency soluble prokaryotic expression, purification, and structural analysis of antimicrobial peptide G13. Protein Expr Purif. 2016;119:45-50 pubmed publisher
    b>G13 is a 19-residue cationic antimicrobial peptide derived from granulysin...
  89. Dubois S, Viailly P, Mareschal S, Bohers E, Bertrand P, Ruminy P, et al. Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study. Clin Cancer Res. 2016;22:2919-28 pubmed publisher
    ..Clin Cancer Res; 22(12); 2919-28. ©2016 AACRSee related commentary by Lim and Elenitoba-Johnson, p. 2829. ..
  90. Scarlett K, White E, Coke C, Carter J, Bryant L, Hinton C. Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration. Mol Cancer Res. 2018;16:728-739 pubmed publisher
    ..b>Implications: This study investigates a signaling mechanism by which GPCR heterodimerization inhibits cancer cell migration. Mol Cancer Res; 16(4); 728-39. ©2018 AACR. ..
  91. Johnson E, Seasholtz T, Waheed A, Kreutz B, Suzuki N, Kozasa T, et al. RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol. 2003;5:1095-103 pubmed
    b>G alpha 13 stimulates the guanine nucleotide exchange factors (GEFs) for Rho, such as p115Rho-GEF...
  92. Pianezze G, Toniolo M, Taddei Masieri M, Dolcini B, Ravani A. Hb Belluno [?111(G13)Val?Gly;?133(H11)Val?Val (HBB: c.335T?>?G;402G?>?C)]: Incidental Detection of a New Clinically Silent ? Chain Variant During Hb A1c Determination by High Performance Liquid Chromatography. Hemoglobin. 2016;40:143-9 pubmed publisher
    A previously unreported ? chain variant, Hb Belluno [?111(G13)Val?Gly;?133(H11)Val?Val (HBB: c.335T?>?G;402G?>?C)], was incidentally discovered in a woman suffering from diabetes, during glycated hemoglobin (Hb A1c) assay...