GALNT3

Summary

Gene Symbol: GALNT3
Description: polypeptide N-acetylgalactosaminyltransferase 3
Alias: GalNAc-T3, HFTC, HHS, polypeptide N-acetylgalactosaminyltransferase 3, GalNAc transferase 3, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3), polypeptide GalNAc transferase 3, polypeptide GalNAc-transferase T3, pp-GaNTase 3, protein-UDP acetylgalactosaminyltransferase 3
Species: human
Products:     GALNT3

Top Publications

  1. Dosaka Akita H, Kinoshita I, Yamazaki K, Izumi H, Itoh T, Katoh H, et al. N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers. Br J Cancer. 2002;87:751-5 pubmed
    ..04; P=0.03), and in pStage I nonsquamous cell carcinomas (hazards ratio, 2.70; P=0.03). These results suggest that GalNAc-T3 is a new marker of non-small cell lung cancers with specificity for histology and prognosis. ..
  2. Gu C, Oyama T, Osaki T, Li J, Takenoyama M, Izumi H, et al. Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence. Br J Cancer. 2004;90:436-42 pubmed
    ..019, rr=3.05, respectively). The low expression of GalNAc-T3 may be a useful marker for predicting poor prognosis and early recurrence in completely resected lung carcinoma patients, particularly patients with stage I diseases. ..
  3. Yamamoto S, Nakamori S, Tsujie M, Takahashi Y, Nagano H, Dono K, et al. Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas. Pathobiology. 2004;71:12-8 pubmed
    ..001) and T4 of the pTNM staging system (p < 0.05). These findings indicate that the expression of GalNAc-T3 is associated with the differentiation and aggressiveness of ductal adenocarcinoma of the pancreas. ..
  4. Miyahara N, Shoda J, Kawamoto T, Furukawa M, Ueda T, Todoroki T, et al. Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder. Clin Cancer Res. 2004;10:2090-9 pubmed
    ..This phenotype may serve as a unique biological feature associated with the malignant behavior. ..
  5. Onitsuka K, Shibao K, Nakayama Y, Minagawa N, Hirata K, Izumi H, et al. Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma. Cancer Sci. 2003;94:32-6 pubmed
    ..0158, Cox proportional hazards model). Our data suggest that GalNAc-T3 expression may be a useful marker for prognosis and differentiation of gastric carcinomas. ..
  6. Inoue T, Eguchi T, Oda Y, Nishiyama K, Fujii K, Izumi H, et al. Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-. Mod Pathol. 2007;20:267-76 pubmed
    ..Clinically, preoperative evaluation of GalNAc-T3 expression is considered to be useful for decisions regarding operative procedures. ..
  7. Wandall H, Hassan H, Mirgorodskaya E, Kristensen A, Roepstorff P, Bennett E, et al. Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. J Biol Chem. 1997;272:23503-14 pubmed
    ..The results demonstrate that individual GalNAc-transferases have distinct activities and the initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases. ..
  8. Kitada S, Yamada S, Kuma A, Ouchi S, Tasaki T, Nabeshima A, et al. Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. Br J Cancer. 2013;109:472-81 pubmed publisher
    ..N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with RCC, and may offer a therapeutic target against RCC. ..
  9. Bennett E, Hassan H, Clausen H. cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. J Biol Chem. 1996;271:17006-12 pubmed
    ..Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3. ..

More Information

Publications134 found, 100 shown here

  1. Topaz O, Shurman D, Bergman R, Indelman M, Ratajczak P, Mizrachi M, et al. Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet. 2004;36:579-81 pubmed
    ..Using linkage analysis, we mapped the gene underlying FTC to 2q24-q31. This region includes the gene GALNT3, which encodes a glycosyltransferase responsible for initiating mucin-type O-glycosylation...
  2. Taniuchi K, Cerny R, Tanouchi A, Kohno K, Kotani N, Honke K, et al. Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth. Oncogene. 2011;30:4843-54 pubmed publisher
    ..Thus, substrate proteins of GalNAc-T3 should serve as important therapeutic targets for pancreatic cancers. ..
  3. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..associated tail protein 1 like (ROPN1L); down-regulated: polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), carbonic anhydrase 14 (CAXIV), BCL2-related protein A1 (BCL2A1), protein kinase C delta (PRKCD), transient ..
  4. Jellinger P, Handelsman Y, Rosenblit P, Bloomgarden Z, Fonseca V, Garber A, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE. Endocr Pract. 2017;23:1-87 pubmed publisher
    ..Treatment Study HDL-C = high-density lipoprotein cholesterol HeFH = heterozygous familial hypercholesterolemia HHS = Helsinki Heart Study HIV = human immunodeficiency virus HoFH = homozygous familial hypercholesterolemia HPS = ..
  5. Sahasrabudhe N, Lenos K, van der Horst J, Rodriguez E, van Vliet S. Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3. Biol Chem. 2018;399:649-659 pubmed publisher
    ..Both the activity and expression of C1GalT1 and COSMC were unrelated to the BRAF mutational status. In contrast, GALNT3, GALNT7 and GALNT12 were increased in colorectal cancer cells harboring the BRAFV600E mutation...
  6. Stastný E, Trc T, Frydl J, Kopecný Z, Philippou T, Lisy J. [Mid-Term to Long-Term Results of Revision Total Hip Arthroplasty Using the Oval-Shaped Acetabular Cup - TC Type]. Acta Chir Orthop Traumatol Cech. 2017;84:271-278 pubmed
    ..The mean value for HHS increased from 39.5 to 84.5...
  7. Ren G, Lutz I, Railton P, Wiley J, McAllister J, Powell J, et al. Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain. BMC Musculoskelet Disord. 2018;19:39 pubmed publisher
    ..Pain, physical function and activity within the hip OA cohort were examined using the HOOS, SF-36, HHS and UCLA outcome measures. The three cohorts showed distinct serum cytokine profiles...
  8. Zhu X, Yuan L, Han G, Han J, Zhou J. [Short term effect of total hip arthroplasty through direct anterior approach for the treatment of ankylosing spondylitis with hip flexion deformity]. Zhongguo Gu Shang. 2019;32:141-145 pubmed publisher
    ..05). There was no significant difference in the scores of HHS, total hip motion and VAS at 1, 6 months after operation(P>0.05)...
  9. Ozden V, Dikmen G, Beksac B, Tozun I. Tapered stems one-third proximally coated have higher complication rates than cylindrical two-third coated stems in patients with high hip dislocation undergoing total hip arthroplasty with step-cut shortening osteotomy. Orthop Traumatol Surg Res. 2017;103:569-577 pubmed publisher
    ..Harris hip scores (HHS) and a University of California Los Angeles (UCLA) activity scores were calculated for all patients and successive ..
  10. Esapa C, Hannan F, Babinsky V, Potter P, Thomas G, Croucher P, et al. N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. PLoS ONE. 2015;10:e0122650 pubmed publisher
    ..have revealed mutations of fibroblast growth factor 23 (FGF23), polypeptide N-acetyl galactosaminyltransferase 3 (GALNT3) and klotho (KL), which are all part of a phosphate-regulating pathway...
  11. Haqani B, Fujii N, Kondo N, Kenny G. The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans. Physiol Rep. 2017;5: pubmed publisher
    ..separated by 10 min, initially under low (LHS, to activate sweating without changes in core temperature) and high (HHS, whole-body heating to a core temperature increase of 1.0°C) heat stress conditions...
  12. Musumeci A, Pranovi G, Masiero S. Patient education and rehabilitation after hip arthroplasty in an Italian spa center: a pilot study on its feasibility. Int J Biometeorol. 2018;62:1489-1496 pubmed publisher
    ..Harris Hip Score (HHS) and SF-12 questionnaires (physical-PCS-12-and mental health component-MCS-12) were also administered...
  13. MacVittie T, Farese A, Jackson W. The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship. Health Phys. 2015;109:342-66 pubmed publisher
    ..S. HHS REPORT (2002 to present)...
  14. Parratte S, Ollivier M, Lunebourg A, Flecher X, Argenson J. No Benefit After THA Performed With Computer-assisted Cup Placement: 10-year Results of a Randomized Controlled Study. Clin Orthop Relat Res. 2016;474:2085-93 pubmed publisher
    ..assessed subjective functional outcome and quality of life using validated questionnaires (SF-12, Harris hip score [HHS], Hip injury and Osteoarthritis Outcome Score)...
  15. Guo J, Ito S, Nguyen H, Yamamoto K, Tanoue R, Kunisue T, et al. Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos. Toxicol Appl Pharmacol. 2018;347:23-32 pubmed publisher
    ..Embryos were treated with graded concentration of TCS (0.1, 1 and 10 μg/g egg) at Hamburger Hamilton Stage (HHS) 1 (1st day), followed by 20 days of incubation to HHS 46...
  16. Song R, Cao S. Prediabetes Directly Deteriorates into Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome Triggered by Acute Pancreatitis: A Case Report Illustrating a "Chicken and Egg" Paradigm in Ketosis-Prone Diabetes. Diabetes Ther. 2018;9:1377-1383 pubmed publisher
    ..322 mOsm/kg; she was diagnosed with diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS), and DKA-related abdominal pain...
  17. Goodman C, Russell B, Velez J, Laven J, Bagarozzi D, Moon J, et al. Production of a Sindbis/Eastern Equine Encephalitis chimeric virus inactivated cell culture antigen. J Virol Methods. 2015;223:19-24 pubmed publisher
    ..However, EEEV is classified as a HHS select agent and requires biosafety level (BSL) three containment, limiting EEEV antigen production in non-select ..
  18. Emadedin M, Karimi S, Karimi A, Labibzadeh N, Niknejadi M, Baharvand H, et al. Autologous bone marrow-derived CD133 cells with core decompression as a novel treatment method for femoral head osteonecrosis: a pilot study. Cytotherapy. 2019;21:107-112 pubmed publisher
    ..The Visual Analogue Scale (VAS), Harris Hip Score (HHS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) and walking distance (WD) were measured before ..
  19. Baugher A, Beer L, Bradley H, Evans M, Luo Q, Shouse R. Behavioral and Clinical Characteristics of American Indian/Alaska Native Adults in HIV Care - Medical Monitoring Project, United States, 2011-2015. MMWR Morb Mortal Wkly Rep. 2019;67:1405-1409 pubmed publisher
    ..S. Department of Health and Human Services' (HHS) annual poverty limit, 27% had symptoms of depression, 78% reported internalized HIV-related stigma, and 20% ..
  20. Schmolders J, Amvrazis G, Pennekamp P, Strauss A, Friedrich M, Wimmer M, et al. Thirteen year follow-up of a cementless femoral stem and a threaded acetabular cup in patients younger than fifty years of age. Int Orthop. 2017;41:39-45 pubmed publisher
    ..Hip disability osteoarthritis and outcome score (HOOS) and Harris hip score (HHS) were used to evaluate the pre- and post-operative functional outcome, respectively...
  21. Li M, Xu C, Xie J, Hu Y, Liu H. Comparison of collum femoris-preserving stems and ribbed stems in primary total hip arthroplasty. J Orthop Surg Res. 2018;13:271 pubmed publisher
    ..4 ± 10.8 and 42.3 ± 9.8 years). Patients were assessed using the Harris Hip Score (HHS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), 12-Item Short Form Health Survey (SF-12), ..
  22. Desse T, Eshetie T, Gudina E. Predictors and treatment outcome of hyperglycemic emergencies at Jimma University Specialized Hospital, southwest Ethiopia. BMC Res Notes. 2015;8:553 pubmed publisher
    Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) commonly known as hyperglycemic emergencies are the two most common life-threatening acute metabolic complications of diabetes...
  23. Jeelani S, Sabesan S, Subramanian S. Community knowledge, awareness and preventive practices regarding dengue fever in Puducherry - South India. Public Health. 2015;129:790-6 pubmed publisher
    ..Between October 2012 & February 2013, an epidemiological survey was conducted among 400 households (HHs) from the most affected areas during dengue outbreak, which came under eight health delivery jurisdictions i.e...
  24. Vernier L, Lenglet A, Hogema B, Moussa A, Ariti C, Vollmer S, et al. Seroprevalence and risk factors of recent infection with hepatitis E virus during an acute outbreak in an urban setting in Chad, 2017. BMC Infect Dis. 2018;18:287 pubmed publisher
    ..9% (> 15 years). Risk factors for recent HEV infections included: sharing the sanitation facility with other HHs (PR 1.72; 95%CI: 1.08-2.73), not systematically using soap for HW (PR 1.85; 95%CI: 1.30-2...
  25. Vojta A, Samaržija I, Bočkor L, Zoldoš V. Glyco-genes change expression in cancer through aberrant methylation. Biochim Biophys Acta. 2016;1860:1776-85 pubmed publisher
    ..Ten glyco-genes (GALNT3, GALNT6, GALNT7, GALNT14, MGAT3, MAN1A1, MAN1C1, ST3GAL2, ST6GAL1, ST8SIA3) showing changes in both methylation ..
  26. Sun Q, Li G, Ge W, Lu G, Cai M, Li S. [Effectiveness analysis of surgical treatment of ipsilateral femoral neck fracture and subtrochanteric fracture]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017;31:1043-1048 pubmed publisher
    ..Harris 髋关节功能评分(HHS)为 72~92 分,平均 82.8 分;15 例患者(78.9%)髋关节功能良好。...
  27. Huang C, Lin Y, Liu Y, Lin S, Kang B. Hyperglycemia crisis in head and neck cancer patients with platinum-based chemotherapy. J Chin Med Assoc. 2018;81:1060-1064 pubmed publisher
    ..in platinum-based chemotherapy-treated head and neck cancer patients, such as hyperosmolar hyperglycemic state (HHS), has been reported...
  28. Bali K, Railton P, Kiefer G, Powell J. Subcapital osteotomy of the femoral neck for patients with healed slipped capital femoral epiphysis. Bone Joint J. 2014;96-B:1441-8 pubmed publisher
    ..Clinical assessment included measurement of range of movement, Harris Hip Score (HHS) and Western Ontario and McMaster Universities Osteoarthritis score (WOMAC)...
  29. Yamaguchi H, Sakaguchi H, Yoshida K, Yabe M, Yabe H, Okuno Y, et al. Clinical and genetic features of dyskeratosis congenita, cryptic dyskeratosis congenita, and Hoyeraal-Hreidarsson syndrome in Japan. Int J Hematol. 2015;102:544-52 pubmed publisher
    ..Hoyeraal-Hreidarsson syndrome (HHS) is considered to be a severe form of DKC...
  30. Rashed R, Sevenoaks H, Shabaan A, Choudry Q, Hammad A, Kasem M, et al. Functional outcome and health related quality of life after dual mobility cup total hip replacement for displaced femoral neck fractures in middle aged Egyptian patients. Injury. 2018;49:667-672 pubmed publisher
    ..Functional assessment was done using Harris Hip Score (HHS), SF-36 questionnaire for health related quality of life (HRQoL) with assistance of a physiotherapist...
  31. Beauchamp G, McKeown N, Rodriguez S, Spyker D. Relating calls to US poison centers for potential exposures to medications to Centers for Disease Control and Prevention reporting of influenza-like illness. Clin Toxicol (Phila). 2016;54:235-40 pubmed publisher
    ..The CDC reports ILI, by age group, for each of 10 Health and Human Services (HHS) regions...
  32. Valeri C, Giorgio G. Commentary on 50 years of research at the NBRL, Boston, Massachusetts. Transfus Apher Sci. 2016;54:16-20 pubmed publisher
    ..over the past 50 years and the 15-year experience by the Netherlands military now recommend that FDA, ARC, HHS and DOD should support the use of universal donor frozen group O Rh positive and group O Rh negative RBC, frozen ..
  33. Guzik G. Treatment of metastatic lesions localized in the acetabulum. J Orthop Surg Res. 2016;11:54 pubmed publisher
    ..7, and the mean Karnofsky functional status score was 71.8. The mean postoperative Harris hip score (HHS) was 94 points...
  34. Millen B, Abrams S, Adams Campbell L, Anderson C, Brenna J, Campbell W, et al. The 2015 Dietary Guidelines Advisory Committee Scientific Report: Development and Major Conclusions. Adv Nutr. 2016;7:438-44 pubmed publisher
    ..Guidelines for Americans (DGA) is published every 5 y jointly by the Department of Health and Human Services (HHS) and the USDA and provides a framework for US-based food and nutrition programs, health promotion and disease ..
  35. Honkavaara N, Al Ani A, Campenfeldt P, Ekström W, Hedstrom M. Good responsiveness with EuroQol 5-Dimension questionnaire and Short Form (36) Health Survey in 20-69 years old patients with a femoral neck fracture: A 2-year prospective follow-up study in 182 patients. Injury. 2016;47:1692-7 pubmed publisher
    ..HRQoL was measured by EQ-5D and SF-36 at 4, 12 and 24 months. Pain and function were measured by Harris Hip Score (HHS) on the same occasions...
  36. Lorenz V, Cejas R, Bennett E, Nores G, Irazoqui F. Functional control of polypeptide GalNAc-transferase 3 through an acetylation site in the C-terminal lectin domain. Biol Chem. 2017;398:1237-1246 pubmed publisher
    ..We propose that acetylated residues on ppGalNAc-T3 function as control points for enzyme activity, and high level of GlcNAc glycosides promote a synergistic regulatory mechanism, leading to a metabolically disordered state. ..
  37. Claramunt Taberner D, Bertholet Thomas A, Carlier M, Dijoud F, Chotel F, Silve C, et al. Hyperphosphatemic tumoral calcinosis caused by FGF23 compound heterozygous mutations: what are the therapeutic options for a better control of phosphatemia?. Pediatr Nephrol. 2018;33:1263-1267 pubmed publisher
    Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disease caused by mutations in genes encoding FGF23 or its regulators, and leading to functional deficiency or resistance to fibroblast growth factor 23 (..
  38. Ackerman D, Craft K, Townsend S. Infant food applications of complex carbohydrates: Structure, synthesis, and function. Carbohydr Res. 2017;437:16-27 pubmed publisher
    ..S. Department of Health and Human Services (HHS) recommend breast milk as the sole source of food during the first year of life...
  39. Echouffo Tcheugui J, Garg R. Management of Hyperglycemia and Diabetes in the Emergency Department. Curr Diab Rep. 2017;17:56 pubmed publisher
    ..Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are hyperglycemic emergencies that commonly present to the ED...
  40. Dan C, Moses Eisenstein M, Valdiserri R. CE: Viral Hepatitis: New U.S. Screening Recommendations, Assessment Tools, and Treatments. Am J Nurs. 2015;115:26-35; quiz 36, 48 pubmed publisher
    ..S. Department of Health and Human Services (HHS) seem likely to lead to significant progress in the coming years...
  41. Hochreiter J, Brusaferri G, Kirschbichler K, Emmanuel K. Long-term follow-up of primary total hip arthroplasty with the Alloclassic Variall system. Int Orthop. 2016;40:1409-15 pubmed publisher
    ..3 years (interquartile range [IQR] 8.8-9.8 years). The median Harris hip score (HHS) was 99.9 points (IQR 97.7-100). The score did not differ significantly between the two articulations...
  42. Laino L, Elia F, Desiderio F, Scarabello A, Sperduti I, Cota C, et al. The efficacy of a photolyase-based device on the cancerization field: a clinical and thermographic study. J Exp Clin Cancer Res. 2015;34:84 pubmed publisher
    ..The Authors hypothesize HH as a possible expression of CF. The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy ..
  43. MacEwen A, Carty D, McConnachie A, McKay G, Boyle J. A "Diabetes Acute Care Day" for medical students increases their knowledge and confidence of diabetes care: a pilot study. BMC Med Educ. 2016;16:88 pubmed publisher
    ..care followed by case-based learning tutorials on diabetic ketoacidosis (DKA), hyperosmolar hyperglycaemic state (HHS) and hypoglycaemia using capillary blood glucose charts to interpret and practice subsequent insulin prescription ..
  44. Amano T, Hasegawa Y, Seki T, Takegami Y, Murotani K, Ishiguro N. Preoperative prognosis score is a useful tool regarding eccentric rotational acetabular osteotomy in patients with acetabular dysplasia. J Orthop Sci. 2016;21:348-53 pubmed publisher
    ..and multivariate Cox regression were performed using the time from the day of surgery to a Harris hip score (HHS) <80 as an endpoint...
  45. Döring R, Jentzsch T, Scheyerer M, Pfäffli W, Werner C. The value of modular hemiarthroplasty for unstable femoral neck fractures in elderly patients with coxarthrosis. BMC Musculoskelet Disord. 2016;17:223 pubmed publisher
    ..Most patients showed a decreased offset by a mean of -7.8 mm. The mean modified Harris Hip Score (HHS) of 90.3 and the mean Merle d'Aubigné score of 10.8 correlated significantly...
  46. Ichikawa S, Gerard O Riley R, Acton D, McQueen A, Strobel I, Witcher P, et al. A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice. Endocrinology. 2017;158:470-476 pubmed publisher
    ..To test the presence of the similar set point defect in ARHR, we generated 4- and 12-week-old Dmp1/Galnt3 double knockout mice and controls, including Dmp1 knockout mice (a murine model of ARHR), Galnt3 knockout mice (a ..
  47. Kamiński P, Szmyd J, Ambroży J, Jaworski J, Frańczuk B. A Comparison of Outcomes of Treatment with Resection Prosthesis of the Hip in Revision and Oncological Surgery. Ortop Traumatol Rehabil. 2017;19:145-156 pubmed
    ..No statistically significant differences were observed between the groups in the post-operative HHS scores and pain assessment in the VAS scale...
  48. Faldini C, Nanni M, Leonetti D, Miscione M, Acri F, Giannini S. Total hip arthroplasty in developmental hip dysplasia using cementless tapered stem. Results after a minimum 10-year follow-up. Hip Int. 2011;21:415-20 pubmed publisher
    ..Clinical evaluation was conducted using the Harris Hip Score (HHS). Radiographic evaluation consisted in standard anteroposterior and axial view radiographs of the hip...
  49. Falzarano G, Piscopo A, Rollo G, Medici A, Grubor P, Bisaccia M, et al. Tantalum in type IV and V Paprosky periprosthetic acetabular fractures surgery in Paprosky type IV and V periprosthetic acetabular fractures surgery. Musculoskelet Surg. 2018;102:87-92 pubmed publisher
    ..7/10 cm at time 0 and gradually returns to basic pre-injury values in the following months. The average value of HHS at time 0 is 13.5 points. This value tends to increase progressively until reaching a mean score of 89...
  50. Spina M, Scalvi A. Vancouver B2 periprosthetic femoral fractures: a comparative study of stem revision versus internal fixation with plate. Eur J Orthop Surg Traumatol. 2018;28:1133-1142 pubmed publisher
    ..At an average follow-up of 30.1 months in group 1, we had 36.4% of patients with complications, HHS of 66.8, radiographic outcome "excellent-good" in 91% of cases...
  51. Pogliacomi F, Paraskevopoulos A, Costantino C, Marenghi P, Ceccarelli F. Influence of surgical experience in the learning curve of a new approach in hip replacement: anterior mini-invasive vs. standard lateral. Hip Int. 2012;22:555-61 pubmed publisher
    ..Harris Hip Score (HHS) and Hip Disability and Osteoarthritis Outcome Score (HOOS) were analysed before and 12 months after surgery...
  52. Hjorth M, Stilling M, Soballe K, Bolvig L, Thyssen J, Mechlenburg I, et al. No association between pseudotumors, high serum metal-ion levels and metal hypersensitivity in large-head metal-on-metal total hip arthroplasty at 5-7-year follow-up. Skeletal Radiol. 2016;45:115-25 pubmed publisher
    ..and atopic dermatitis were evaluated, and the questionnaires of the Oxford Hip Score (OHS), Harris Hip Score (HHS) and the Short-Form Health Survey (SF-36) were completed...
  53. McLean J, Cappelletto J, Clarnette J, Hill C, Gill T, Mandziak D, et al. Normal population reference values for the Oxford and Harris Hip Scores - electronic data collection and its implications for clinical practice. Hip Int. 2017;27:389-396 pubmed publisher
    The aim of this study was to assess whether the Harris Hip Score (HHS) and the Oxford Hip Score (OHS) were comparable in normal, healthy, pathology-free individuals of different age, gender, ethnicity, handedness and nationality...
  54. Park K, Chan C, Lee G, Ahn H, Yoon T. Outcome of alternative approach to displaced acetabular fractures. Injury. 2017;48:388-393 pubmed publisher
    ..Mean operation time was 160min (range: 75-320min). Functional scores were evaluated using Harris Hip Score (HHS) whilst reduction was assessed by Matta criteria...
  55. Eriksson J, Blanco Pastor J, Sousa F, Bertrand Y, Pfeil B. A cryptic species produced by autopolyploidy and subsequent introgression involving Medicago prostrata (Fabaceae). Mol Phylogenet Evol. 2017;107:367-381 pubmed publisher
    ..through genome duplication is well known, hybridisation without genome duplication (homoploid hybrid speciation, HHS) is not. Few well-documented cases have been reported. A possible instance of HHS in Medicago prostrata Jacq...
  56. Kubo Y, Motomura G, Ikemura S, Sonoda K, Yamamoto T, Nakashima Y. Factors influencing progressive collapse of the transposed necrotic lesion after transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head. Orthop Traumatol Surg Res. 2017;103:217-222 pubmed publisher
    ..The following factors were statistically analyzed: age, sex, body mass index, Harris Hip Score (HHS), preoperative level of collapse, extent of the necrotic lesion and postoperative intact ratio (ratio of the ..
  57. Burnett E, Wannemuehler K, Ngoie Mwamba G, Yolande M, Guylain K, Muriel N, et al. Individually Linked Household and Health Facility Vaccination Survey in 12 At-risk Districts in Kinshasa Province, Democratic Republic of Congo: Methods and Metadata. J Infect Dis. 2017;216:S237-S243 pubmed publisher
    ..Of the HHs with a child aged 6-23 months, 16% were ineligible because they had resided in the neighborhood for <3 months or ..
  58. Klein C, Fontanarosa A, Khouri N, Bellity J, Padovani J, Glorion C, et al. Anterior and lateral overcoverage after triple pelvic osteotomy in childhood for developmental dislocation of the hip with acetabular dysplasia: Frequency, features, and medium-term clinical impact. Orthop Traumatol Surg Res. 2018;104:383-387 pubmed publisher
    ..1 years (range, 13-39 years). Clinical outcomes were assessed based on the Harris Hip Score (HHS) and Postel-Merle d'Aubigné (PMA) score...
  59. D Angelo F, Murena L, Vulcano E, Zatti G, Cherubino P. Seven to twelve year results with Versys ET cementless stem. A retrospective study of 225 cases. Hip Int. 2010;20:81-6 pubmed
    ..stem displayed a varus alignment between 5 degrees and 10 degrees in 17 cases without any clinical consequences (HHS 96.8). We recorded one case of septic loosening and one case of aseptic loosening...
  60. Salama W, Mousa S, Khalefa A, Sleem A, Kenawey M, Ravera L, et al. Simultaneous open reduction and internal fixation and total hip arthroplasty for the treatment of osteoporotic acetabular fractures. Int Orthop. 2017;41:181-189 pubmed publisher
    ..Thirteen patients (72.7 %) had excellent Harris hip scores HHS, five, patients (27.7 %) had good results...
  61. Kutzner K, Freitag T, Donner S, Kovacevic M, Bieger R. Outcome of extensive varus and valgus stem alignment in short-stem THA: clinical and radiological analysis using EBRA-FCA. Arch Orthop Trauma Surg. 2017;137:431-439 pubmed publisher
    ..The incidence of stress-shielding and cortical hypertrophy as well as clinical outcome [Harris Hip Score (HHS)] were reported. Postoperative CCD angles ranged from 117.9° to 145...
  62. Fayfman M, Pasquel F, Umpierrez G. Management of Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State. Med Clin North Am. 2017;101:587-606 pubmed publisher
    Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are the most serious and life-threatening hyperglycemic emergencies in diabetes...
  63. Lu Y, Wang N, He J, Li Y, Gao X, Huang L, et al. Expression and characterization of a novel chitinase with antifungal activity from a rare actinomycete, Saccharothrix yanglingensis Hhs.015. Protein Expr Purif. 2018;143:45-51 pubmed publisher
    Saccharothrix yanglingensis Hhs.015, a new type of rare actinomycete, was isolated from the roots of cucumber. A novel chitinase gene was cloned from S. yanglingensis Hhs.015 and overexpressed as a soluble protein Chi6769 (77...
  64. Tateuchi H, Akiyama H, Goto K, So K, Kuroda Y, Ichihashi N. Sagittal alignment and mobility of the thoracolumbar spine are associated with radiographic progression of secondary hip osteoarthritis. Osteoarthritis Cartilage. 2018;26:397-404 pubmed publisher
    ..The independent variables were hip pain, Harris hip score (HHS), hip morphological parameters, hip passive range of motion (ROM) and muscle strength, and alignment and mobility ..
  65. Yu X, Zhao D, Huang S, Wang B, Zhang X, Wang W, et al. Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults. BMC Musculoskelet Disord. 2015;16:329 pubmed publisher
    ..According to the Harris hip score (HHS) that was available for 17 hips with satisfactory union, excellent results were achieved in 14 cases (HHS â..
  66. Perticarini L, Zanon G, Rossi S, Benazzo F. Clinical and radiographic outcomes of a trabecular titaniumâ„¢ acetabular component in hip arthroplasty: results at minimum 5 years follow-up. BMC Musculoskelet Disord. 2015;16:375 pubmed publisher
    ..Mean follow-up was 72.7 ± 7.9 SD (60-86) months. Average Harris Hip Score (HHS) significantly increased from 44.2 ± 5.4 SD (35-52) preoperatively to 95.9 ± 3...
  67. Tetsunaga T, Fujiwara K, Endo H, Noda T, Tetsunaga T, Sato T, et al. Total hip arthroplasty after failed treatment of proximal femur fracture. Arch Orthop Trauma Surg. 2017;137:417-424 pubmed publisher
    ..compared included radiographic assessment, complication rate, visual analogue scale (VAS), and Harris Hip Scores (HHS). Radiographic variables included femoral neck anteversion and cup and stem alignment...
  68. Rigault G, Franko B, Chabre O, Quemerai M, Némoz B, Zaoui P. [Hyponatremic-hypertensive syndrome successfully treated by endovascular therapy: A case report]. Ann Cardiol Angeiol (Paris). 2017;66:243-245 pubmed publisher
    Hyponatremic-hypertensive syndrome (HHS) is characterized by hypertension and hyponatremia...
  69. Pascarella R, Cerbasi S, Politano R, Balato G, Fantasia R, Orabona G, et al. Surgical results and factors influencing outcome in patients with posterior wall acetabular fracture. Injury. 2017;48:1819-1824 pubmed publisher
    ..The functional outcome was evaluated with use of the modified Merle d'Aubigne scoring system, the Harris Hip Score (HHS), and the Short Form-36 Health Survey (SF-36) questionnaire...
  70. Radziszewski M, Kozłowski P. Predicting Functional Outcomes in Patients with Femoral Neck Fractures Treated by Hemiarthroplasty. Ortop Traumatol Rehabil. 2017;19:341-347 pubmed publisher
    ..is to identify factors influencing the functional outcomes of hemiarthroplasty measured with the Harris Hip Score (HHS) in patients with femoral neck fractures...
  71. Chughtai M, Mistry J, Diedrich A, Jauregui J, Elmallah R, Bonutti P, et al. Low Frequency of Early Complications With Dual-mobility Acetabular Cups in Cementless Primary THA. Clin Orthop Relat Res. 2016;474:2181-7 pubmed publisher
    ..Clinical outcomes were evaluated using the Harris hip score (HHS); radiographs were assessed for cup migration, progressive radiolucencies, and positional changes of the components;..
  72. Sayed Noor A, Hanas A, Skoldenberg O, Mukka S. Abductor Muscle Function and Trochanteric Tenderness After Hemiarthroplasty for Femoral Neck Fracture. J Orthop Trauma. 2016;30:e194-200 pubmed publisher
    ..Preoperatively, we evaluated the Harris hip score (HHS) and European Quality of Life-5 Dimensions (EQ-5D)...
  73. Marczak D, Synder M, Sibinski M, Polguj M, Dudka J, Kowalczewski J. Two stage revision hip arthroplasty in periprosthetic joint infection. Comparison study: with or without the use of a spacer. Int Orthop. 2017;41:2253-2258 pubmed publisher
    ..The improvement in final function was better in the spacer group with regard to HHS, but not according to WOMAC score or VAS at final follow-up...
  74. Heffler M, Barlow R, Xi Y, Hayashi D, Box H, Huo M, et al. Multi-parametric muscle and fat correlation of computed tomography parameters to outcomes in a total hip arthroplasty population. BMC Musculoskelet Disord. 2018;19:4 pubmed publisher
    ..a CT between 1 year before and 6 months after surgery, and (3) completed perioperative WOMAC and Harris Hip Score (HHS) questionnaires...
  75. Bennett E, Weghuis D, Merkx G, van Kessel A, Eiberg H, Clausen H. Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. Glycobiology. 1998;8:547-55 pubmed
    ..These results suggest that the members of the polypeptide GalNAc-transferase family diverged early in evolution from a common ancestral gene through gene duplication. ..
  76. Yasmeen S, Siddique N, Athar Abbas M, Ali A, Rafique S, Rashid F, et al. Fiber gene based molecular and biological characterization of hydropericardium-hepatitis syndrome associated avian adenoviruses. Iran J Vet Res. 2017;18:190-196 pubmed
    ..of avian adenoviruses (AAVs) recovered from suspected cases of hydropericardium-hepatitis syndrome (HHS) in commercial poultry...
  77. Pontes J, Mendes F, Vasconcelos M, Batista N. [Evaluation and perioperative management of patients with diabetes mellitus. A challenge for the anesthesiologist]. Rev Bras Anestesiol. 2018;68:75-86 pubmed publisher
    ..treated with multiple injectable and/or oral drugs are susceptible to develop a hyperglycemic hyperosmolar state (HHS)...
  78. Kalscheuer H, Serfling G, Schmid S, Lehnert H. [Diabetic emergencies : Hypoglycemia, ketoacidotic and hyperglycemic hyperosmolar nonketotic coma]. Internist (Berl). 2017;58:1020-1028 pubmed publisher
    The diabetic emergencies diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS) and hypoglycemia represent severe and potentially life-threatening complications of diabetes mellitus that require prompt diagnostics and ..
  79. Mochizuki Y, Ito K, Izumi H, Kohno K, Amano J. Expression of polypeptide N-acetylgalactosaminyl transferase-3 and its association with clinicopathological factors in thyroid carcinomas. Thyroid. 2013;23:1553-60 pubmed publisher
    ..Positive staining for GalNAc-T3 was not observed in any of the medullary carcinomas. Our data suggest that GalNAc-T3 expression may be a useful indicator of tumor differentiation in thyroid carcinomas. ..
  80. Kemp J, Medina Gomez C, Estrada K, St Pourcain B, Heppe D, Warrington N, et al. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet. 2014;10:e1004423 pubmed publisher
    ..Allowing for these differences by performing genome-wide association at different skeletal sites may help uncover new genetic influences on BMD. ..
  81. Guo L, Li D, Li M, Li L, Huang Y. Variant in GALNT3 Gene Linked with Reduced Coronary Artery Disease Risk in Chinese Population. DNA Cell Biol. 2017;36:529-534 pubmed publisher
    Our previous study found expression of GALNT3 gene was reduced in coronary artery disease (CAD) patients, and it contributed to endothelial injury by regulating apoptosis and matrix metalloproteinase (MMP) expression...
  82. Salama W, Ditto P, Mousa S, Khalefa A, Sleem A, Ravera L, et al. Cementless total hip arthroplasty in the treatment after acetabular fractures. Eur J Orthop Surg Traumatol. 2018;28:59-64 pubmed publisher
    ..all patients could walk independently, thirteen (62%) patients had excellent Harris hip score, five (24%) had good HHS, and 3 (14%) had fair score. WOMAC scale decreased from 63 (range 42-92) to 4 (range 0-19). Two patients (9...
  83. Kruljac I, Ćaćić M, Ćaćić P, Biloš L, Kust D, Perić B, et al. The Impact of Hyperosmolarity on Long-Term Outcome in Patients Presenting with Severe Hyperglycemic Crisis: A Population Based Study. Exp Clin Endocrinol Diabetes. 2017;: pubmed publisher
    b>Aims We compared characteristics of patients with hyperglycemic hyperosmolar state (HHS) and patients with severe hyperglycemia without the signs of hyperosmolarity and ketoacidosis; analyzed long-term all-cause mortality and ..
  84. Li N, Wang X, Jiang Y, Wang W, Huang W, Zheng X, et al. Association of GALNT3 gene polymorphisms with bone mineral density in Chinese postmenopausal women: the Peking Vertebral Fracture study. Menopause. 2014;21:515-21 pubmed publisher
    b>GALNT3 gene encodes the glycosyltransferase polypeptide N-acetylgalactosaminyltransferase-3 (ppGalNacT3), which initiates the O-glycosylation of fibroblast growth factor 23 (FGF23) that is important in phosphorous regulation...
  85. Morote R, Hjemdal O, Krysinska K, Martinez Uribe P, Corveleyn J. Resilience or hope? Incremental and convergent validity of the resilience scale for adults (RSA) and the Herth hope scale (HHS) in the prediction of anxiety and depression. BMC Psychol. 2017;5:36 pubmed publisher
    ..the convergent and incremental validity of the Resilience Scale for Adults (RSA) and the Herth Hope Scale (HHS), in the prediction of anxiety and depression (HSCL-25)...
  86. ARGUESO P, Tisdale A, Mandel U, Letko E, Foster C, Gipson I. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Invest Ophthalmol Vis Sci. 2003;44:86-92 pubmed
    ..This early increase in isoenzymes in nonkeratinized OCP epithelia is reduced as keratinization proceeds in the disease. ..
  87. Montalti M, Pilla F, Guerra G, Traina F. Periprosthetic femoral fractures: treatments ?and outcomes. An analysis of 47 cases. Hip Int. 2013;23:380-5 pubmed publisher
    ..The mean HHS at the most recent ?follow-up was 74 (range 49-91)...
  88. Putananon C, Tuchinda H, Arirachakaran A, Wongsak S, Narinsorasak T, Kongtharvonskul J. Comparison of direct anterior, lateral, posterior and posterior-2 approaches in total hip arthroplasty: network meta-analysis. Eur J Orthop Surg Traumatol. 2018;28:255-267 pubmed publisher
    ..posterior and posterior-2 approaches with the pooled mean postoperative within 1 month and last follow-up of HHS of 2.56 (95% CI - 0.79, 5.91), 4.80 (95% CI 1.33, 8.26), 10.80 (95% CI 2.10, 19.49) and 6.40 (95% CI 0.72, 12...
  89. Lavrsen K, Dabelsteen S, Vakhrushev S, Levann A, Haue A, Dylander A, et al. De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium. J Biol Chem. 2018;293:1298-1314 pubmed publisher
    ..Taken together, these data strongly suggest that aberrant GalNAc-T6 expression and site-specific glycosylation is involved in oncogenic transformation. ..
  90. Hussain M, Nasir J, Al Aama J. Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. J Cell Biochem. 2014;115:313-27 pubmed publisher
    ..significant mutations (nsSNPs/single amino acid change) at both functional and structural levels, found in human GALNT3, GALNT8, GALNT12, and GALNT13 genes...
  91. Haversath M, Wendelborn C, Jäger M, Schmidt B, Kowalczyk W, Landgraeber S. Geometric analysis and clinical outcome of two cemented stems for primary total hip replacement with and without modular necks. Arch Orthop Trauma Surg. 2017;137:1571-1578 pubmed publisher
    ..Preoperative planning was compared to postoperative radiographs (femoral offset, leg-length), and clinical scores (HHS, WOMAC, total range of motion) were assessed preoperatively, and then 1 and 2 years after surgery...
  92. Taheriazam A, Saeidinia A. Conversion of failed hemiarthroplasty to total hip arthroplasty: A short-term follow-up study. Medicine (Baltimore). 2017;96:e8235 pubmed publisher
    ..We used Harris Hip Score (HHS) to evaluate the results of conversion procedure in terms of relief of groin pain and functional improvement...